SIMILAR PATTERNS OF AMINO ACIDS FOR 1GMK_A_DVAA6_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evh PROTEIN (MENA EVH1
DOMAIN)

(Mus musculus) 		PF00568
(WH1) 		3 ALA A  83
VAL A  86
TRP A  80
 None
 0.96A 1gmkA-1evhA:
undetectable
1gmkB-1evhA:
undetectable		 1gmkA-1evhA:
7.14
1gmkB-1evhA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3y DIADENOSINE
5',5'''-P1,P4-TETRAP
HOSPHATE HYDROLASE

(Lupinus
angustifolius) 		PF00293
(NUDIX) 		3 ALA A 104
VAL A  17
TRP A 107
 None
 0.81A 1gmkA-1f3yA:
undetectable
1gmkB-1f3yA:
undetectable		 1gmkA-1f3yA:
9.09
1gmkB-1f3yA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcu HYALURONOGLUCOSAMINI
DASE

(Apis mellifera) 		PF01630
(Glyco_hydro_56) 		3 ALA A  73
VAL A  78
TRP A 115
 None
 0.97A 1gmkA-1fcuA:
undetectable
1gmkB-1fcuA:
undetectable		 1gmkA-1fcuA:
7.14
1gmkB-1fcuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE

(Rattus
norvegicus) 		PF00459
(Inositol_P) 		3 ALA A 250
VAL A 116
TRP A 246
 None
 1.02A 1gmkA-1jp4A:
undetectable
1gmkB-1jp4A:
undetectable		 1gmkA-1jp4A:
3.97
1gmkB-1jp4A:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 3 ALA A 196
VAL A 199
TRP A 200
 None
 1.01A 1gmkA-1juhA:
undetectable
1gmkB-1juhA:
undetectable		 1gmkA-1juhA:
3.27
1gmkB-1juhA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		3 ALA A 335
VAL A 338
TRP A 378
 None
 0.91A 1gmkA-1kfwA:
undetectable
1gmkB-1kfwA:
undetectable		 1gmkA-1kfwA:
3.19
1gmkB-1kfwA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		3 ALA A 646
VAL A 547
TRP A 642
 None
 0.87A 1gmkA-1l1lA:
undetectable
1gmkB-1l1lA:
undetectable		 1gmkA-1l1lA:
2.70
1gmkB-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llc L-LACTATE
DEHYDROGENASE

(Lactobacillus
casei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ALA A 215
VAL A 213
TRP A 212
 None
 0.95A 1gmkA-1llcA:
undetectable
1gmkB-1llcA:
undetectable		 1gmkA-1llcA:
4.84
1gmkB-1llcA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ma1 SUPEROXIDE DISMUTASE

(Methanothermobacter
thermautotrophicus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 122
VAL A 133
TRP A 131
 None
 0.85A 1gmkA-1ma1A:
undetectable
1gmkB-1ma1A:
undetectable		 1gmkA-1ma1A:
10.42
1gmkB-1ma1A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 ALA A 193
VAL A 165
TRP A 240
 None
 1.01A 1gmkA-1o4zA:
undetectable
1gmkB-1o4zA:
undetectable		 1gmkA-1o4zA:
5.21
1gmkB-1o4zA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppr PERIDININ-CHLOROPHYL
L PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		3 ALA M 238
VAL M 241
TRP M 186
 None
PID  M 624 (-4.2A)
PID  M 624 ( 3.6A)
 0.96A 1gmkA-1pprM:
undetectable
1gmkB-1pprM:
undetectable		 1gmkA-1pprM:
7.10
1gmkB-1pprM:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		3 ALA A 196
VAL A 347
TRP A 336
 None
 1.01A 1gmkA-1wstA:
undetectable
1gmkB-1wstA:
undetectable		 1gmkA-1wstA:
5.08
1gmkB-1wstA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0m AMINOTRANSFERASE II
HOMOLOGUE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		3 ALA A 210
VAL A 361
TRP A 350
 None
 1.02A 1gmkA-1x0mA:
undetectable
1gmkB-1x0mA:
undetectable		 1gmkA-1x0mA:
3.01
1gmkB-1x0mA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		3 ALA B   9
VAL B  11
TRP B 107
 None
 0.95A 1gmkA-1y43B:
undetectable
1gmkB-1y43B:
undetectable		 1gmkA-1y43B:
6.13
1gmkB-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ALA A 226
VAL A 198
TRP A 154
 None
 1.03A 1gmkA-2bucA:
undetectable
1gmkB-2bucA:
undetectable		 1gmkA-2bucA:
2.76
1gmkB-2bucA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2co6 PUTATIVE FIMBRIAE
ASSEMBLY CHAPERONE

(Salmonella
enterica) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		3 ALA B 168
VAL B 170
TRP B 203
 None
 1.03A 1gmkA-2co6B:
undetectable
1gmkB-2co6B:
undetectable		 1gmkA-2co6B:
8.05
1gmkB-2co6B:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  85
VAL A 101
TRP A 102
 None
None
MPD  A   1 ( 3.9A)
 0.96A 1gmkA-2d4wA:
undetectable
1gmkB-2d4wA:
undetectable		 1gmkA-2d4wA:
4.98
1gmkB-2d4wA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 ALA A 294
VAL A 113
TRP A  94
 None
 0.91A 1gmkA-2dw6A:
undetectable
1gmkB-2dw6A:
undetectable		 1gmkA-2dw6A:
4.09
1gmkB-2dw6A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erv HYPOTHETICAL PROTEIN
PAER03002360

(Pseudomonas
aeruginosa) 		PF09411
(PagL) 		3 ALA A  55
VAL A  93
TRP A  48
 None
 0.77A 1gmkA-2ervA:
undetectable
1gmkB-2ervA:
undetectable		 1gmkA-2ervA:
9.18
1gmkB-2ervA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		3 ALA A  44
VAL A  36
TRP A 282
 None
 0.94A 1gmkA-2g37A:
undetectable
1gmkB-2g37A:
undetectable		 1gmkA-2g37A:
5.00
1gmkB-2g37A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hly HYPOTHETICAL PROTEIN
ATU2299

(Agrobacterium
fabrum) 		PF09641
(DUF2026) 		3 ALA A 169
VAL A 167
TRP A 171
 None
 1.01A 1gmkA-2hlyA:
undetectable
1gmkB-2hlyA:
undetectable		 1gmkA-2hlyA:
7.87
1gmkB-2hlyA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 ALA A 190
VAL A 170
TRP A 134
 None
 1.02A 1gmkA-2j7cA:
undetectable
1gmkB-2j7cA:
undetectable		 1gmkA-2j7cA:
2.35
1gmkB-2j7cA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		3 ALA A  83
VAL A  87
TRP A 261
 None
 0.95A 1gmkA-2jgpA:
undetectable
1gmkB-2jgpA:
undetectable		 1gmkA-2jgpA:
5.16
1gmkB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4q MAJOR TAIL PROTEIN V

(Escherichia
virus Lambda) 		PF16461
(Phage_TTP_12) 		3 ALA A  80
VAL A 149
TRP A 126
 None
 0.75A 1gmkA-2k4qA:
undetectable
1gmkB-2k4qA:
undetectable		 1gmkA-2k4qA:
10.20
1gmkB-2k4qA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpw LAMIN-B1

(Homo sapiens) 		PF00932
(LTD) 		3 ALA A  80
VAL A  78
TRP A  72
 None
 0.92A 1gmkA-2kpwA:
undetectable
1gmkB-2kpwA:
undetectable		 1gmkA-2kpwA:
4.92
1gmkB-2kpwA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 3 ALA A  28
VAL A  24
TRP A  23
 None
 0.96A 1gmkA-2lgzA:
undetectable
1gmkB-2lgzA:
undetectable		 1gmkA-2lgzA:
3.66
1gmkB-2lgzA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ock VALACYCLOVIR
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 ALA A 235
VAL A 222
TRP A 145
 None
 0.81A 1gmkA-2ockA:
undetectable
1gmkB-2ockA:
undetectable		 1gmkA-2ockA:
6.82
1gmkB-2ockA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 ALA A 165
VAL A 121
TRP A 119
 None
 0.89A 1gmkA-2om5A:
undetectable
1gmkB-2om5A:
undetectable		 1gmkA-2om5A:
5.45
1gmkB-2om5A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		3 ALA C 249
VAL C 208
TRP C 219
 None
 0.75A 1gmkA-2p9nC:
undetectable
1gmkB-2p9nC:
undetectable		 1gmkA-2p9nC:
3.52
1gmkB-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ALA A1033
VAL A1027
TRP A1193
 None
 0.92A 1gmkA-2pffA:
undetectable
1gmkB-2pffA:
undetectable		 1gmkA-2pffA:
1.22
1gmkB-2pffA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ALA A 278
VAL A 281
TRP A 291
 None
 1.03A 1gmkA-2v4jA:
undetectable
1gmkB-2v4jA:
undetectable		 1gmkA-2v4jA:
3.66
1gmkB-2v4jA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ALA A 371
VAL A 373
TRP A 368
 None
 1.01A 1gmkA-2yfqA:
undetectable
1gmkB-2yfqA:
undetectable		 1gmkA-2yfqA:
3.15
1gmkB-2yfqA:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		3 ALA A 210
VAL A 361
TRP A 350
 None
 1.00A 1gmkA-3aovA:
undetectable
1gmkB-3aovA:
undetectable		 1gmkA-3aovA:
2.46
1gmkB-3aovA:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 ALA A 271
VAL A 298
TRP A 323
 None
 0.98A 1gmkA-3axxA:
undetectable
1gmkB-3axxA:
undetectable		 1gmkA-3axxA:
3.23
1gmkB-3axxA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		3 ALA A 227
VAL A  80
TRP A 223
 None
 1.01A 1gmkA-3b8bA:
undetectable
1gmkB-3b8bA:
undetectable		 1gmkA-3b8bA:
10.75
1gmkB-3b8bA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		3 ALA A  74
VAL A  19
TRP A  51
 None
 0.91A 1gmkA-3cj8A:
undetectable
1gmkB-3cj8A:
undetectable		 1gmkA-3cj8A:
7.96
1gmkB-3cj8A:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		3 ALA A 195
VAL A 178
TRP A 239
 None
 0.88A 1gmkA-3fscA:
undetectable
1gmkB-3fscA:
undetectable		 1gmkA-3fscA:
13.89
1gmkB-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		3 ALA A 125
VAL A 123
TRP A 186
 None
 1.01A 1gmkA-3gkbA:
undetectable
1gmkB-3gkbA:
undetectable		 1gmkA-3gkbA:
5.65
1gmkB-3gkbA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 ALA A 234
VAL A 254
TRP A 255
 None
 0.96A 1gmkA-3gyxA:
undetectable
1gmkB-3gyxA:
undetectable		 1gmkA-3gyxA:
2.61
1gmkB-3gyxA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hag CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		3 ALA A 507
VAL A 503
TRP A 472
 None
 0.97A 1gmkA-3hagA:
undetectable
1gmkB-3hagA:
undetectable		 1gmkA-3hagA:
3.21
1gmkB-3hagA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		3 ALA B 349
VAL B 344
TRP B 323
 None
 0.92A 1gmkA-3it4B:
undetectable
1gmkB-3it4B:
undetectable		 1gmkA-3it4B:
8.93
1gmkB-3it4B:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1
VP3

(Parechovirus B;
Parechovirus B) 		no annotation
PF00073
(Rhv) 		3 ALA C  44
VAL A 181
TRP A 150
 None
 0.98A 1gmkA-3jb4C:
undetectable
1gmkB-3jb4C:
undetectable		 1gmkA-3jb4C:
13.58
1gmkB-3jb4C:
13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jd5 28S RIBOSOMAL
PROTEIN S10,
MITOCHONDRIAL
PENTATRICOPEPTIDE
REPEAT
DOMAIN-CONTAINING
PROTEIN 3,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00338
(Ribosomal_S10)
PF00312
(Ribosomal_S15) 		3 ALA J 153
VAL J 155
TRP o  65
 None
 1.02A 1gmkA-3jd5J:
undetectable
1gmkB-3jd5J:
undetectable		 1gmkA-3jd5J:
31.25
1gmkB-3jd5J:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		3 ALA A 186
VAL A 188
TRP A  56
 None
 0.99A 1gmkA-3luyA:
undetectable
1gmkB-3luyA:
undetectable		 1gmkA-3luyA:
3.92
1gmkB-3luyA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		3 ALA A 106
VAL A 104
TRP A 214
 None
 1.01A 1gmkA-3m1uA:
undetectable
1gmkB-3m1uA:
undetectable		 1gmkA-3m1uA:
4.01
1gmkB-3m1uA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		3 ALA A 260
VAL A 262
TRP A 399
 None
 0.87A 1gmkA-3mktA:
undetectable
1gmkB-3mktA:
undetectable		 1gmkA-3mktA:
3.16
1gmkB-3mktA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7

(Homo sapiens) 		PF01094
(ANF_receptor) 		3 ALA A 365
VAL A 362
TRP A 363
 None
 1.03A 1gmkA-3mq4A:
undetectable
1gmkB-3mq4A:
undetectable		 1gmkA-3mq4A:
3.87
1gmkB-3mq4A:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ALA D 197
VAL D 147
TRP D 190
 None
 0.72A 1gmkA-3pqyD:
undetectable
1gmkB-3pqyD:
undetectable		 1gmkA-3pqyD:
7.50
1gmkB-3pqyD:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 ALA A 219
VAL A 164
TRP A 179
 UNX  A 334 ( 4.9A)
None
None
 0.55A 1gmkA-3qz4A:
undetectable
1gmkB-3qz4A:
undetectable		 1gmkA-3qz4A:
10.34
1gmkB-3qz4A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rby UNCHARACTERIZED
PROTEIN YLR301W

(Saccharomyces
cerevisiae) 		PF16815
(HRI1) 		3 ALA A   3
VAL A 132
TRP A 175
 None
 0.92A 1gmkA-3rbyA:
undetectable
1gmkB-3rbyA:
undetectable		 1gmkA-3rbyA:
6.17
1gmkB-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3riq TAILSPIKE PROTEIN

(Salmonella
virus 9NA) 		PF09251
(PhageP22-tail) 		3 ALA A 414
VAL A 412
TRP A 457
 None
 0.85A 1gmkA-3riqA:
undetectable
1gmkB-3riqA:
undetectable		 1gmkA-3riqA:
2.24
1gmkB-3riqA:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 ALA A 314
VAL A 309
TRP A 319
 None
 0.96A 1gmkA-3tatA:
undetectable
1gmkB-3tatA:
undetectable		 1gmkA-3tatA:
3.58
1gmkB-3tatA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 ALA A 394
VAL A 388
TRP A 397
 None
 0.85A 1gmkA-3ut2A:
undetectable
1gmkB-3ut2A:
undetectable		 1gmkA-3ut2A:
3.08
1gmkB-3ut2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		3 ALA A 271
VAL A 298
TRP A 323
 None
 0.99A 1gmkA-3w6mA:
undetectable
1gmkB-3w6mA:
undetectable		 1gmkA-3w6mA:
3.53
1gmkB-3w6mA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		3 ALA A 245
VAL A 228
TRP A 289
 None
 0.95A 1gmkA-3wmyA:
undetectable
1gmkB-3wmyA:
undetectable		 1gmkA-3wmyA:
2.84
1gmkB-3wmyA:
2.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		3 ALA A  52
VAL A  55
TRP A 363
 None
 0.82A 1gmkA-3wwxA:
undetectable
1gmkB-3wwxA:
undetectable		 1gmkA-3wwxA:
8.15
1gmkB-3wwxA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnl PUTATIVE
PNEUMOCOCCAL SURFACE
PROTEIN

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1) 		3 ALA A 264
VAL A 262
TRP A 254
 None
 1.02A 1gmkA-4cnlA:
undetectable
1gmkB-4cnlA:
undetectable		 1gmkA-4cnlA:
4.52
1gmkB-4cnlA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		3 ALA A 259
VAL A 257
TRP A 262
 None
 1.01A 1gmkA-4flmA:
undetectable
1gmkB-4flmA:
undetectable		 1gmkA-4flmA:
4.21
1gmkB-4flmA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		3 ALA A 275
VAL A 280
TRP A 353
 None
 0.98A 1gmkA-4gklA:
undetectable
1gmkB-4gklA:
undetectable		 1gmkA-4gklA:
4.47
1gmkB-4gklA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		3 ALA L 285
VAL L 295
TRP L 420
 None
 1.02A 1gmkA-4heaL:
undetectable
1gmkB-4heaL:
undetectable		 1gmkA-4heaL:
3.06
1gmkB-4heaL:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi4 AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		3 ALA A 184
VAL A 202
TRP A 283
 None
 0.83A 1gmkA-4hi4A:
undetectable
1gmkB-4hi4A:
undetectable		 1gmkA-4hi4A:
8.74
1gmkB-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 ALA A1373
VAL A1371
TRP A1402
 None
 0.84A 1gmkA-4iglA:
undetectable
1gmkB-4iglA:
undetectable		 1gmkA-4iglA:
0.96
1gmkB-4iglA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpq UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF16011
(CBM9_2) 		3 ALA A 101
VAL A 103
TRP A 185
 None
 0.82A 1gmkA-4jpqA:
undetectable
1gmkB-4jpqA:
undetectable		 1gmkA-4jpqA:
8.11
1gmkB-4jpqA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		3 ALA A 165
VAL A 160
TRP A 126
 None
 1.02A 1gmkA-4k70A:
undetectable
1gmkB-4k70A:
undetectable		 1gmkA-4k70A:
16.90
1gmkB-4k70A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		3 ALA A 293
VAL A 111
TRP A  92
 None
 0.90A 1gmkA-4kemA:
undetectable
1gmkB-4kemA:
undetectable		 1gmkA-4kemA:
5.70
1gmkB-4kemA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgp VHH1 CAMELID
NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		3 ALA B  33
VAL B  97
TRP B  36
 None
 0.92A 1gmkA-4lgpB:
undetectable
1gmkB-4lgpB:
undetectable		 1gmkA-4lgpB:
10.28
1gmkB-4lgpB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		3 ALA A 217
VAL A 219
TRP A  26
 None
 0.91A 1gmkA-4lmvA:
undetectable
1gmkB-4lmvA:
undetectable		 1gmkA-4lmvA:
9.17
1gmkB-4lmvA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m64 MELIBIOSE CARRIER
PROTEIN

(Salmonella
enterica) 		PF13347
(MFS_2) 		3 ALA A 242
VAL A 376
TRP A 342
 None
 0.97A 1gmkA-4m64A:
undetectable
1gmkB-4m64A:
undetectable		 1gmkA-4m64A:
4.00
1gmkB-4m64A:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwf FAB AR3C HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ALA A  33
VAL A  93
TRP A  36
 None
 0.93A 1gmkA-4mwfA:
undetectable
1gmkB-4mwfA:
undetectable		 1gmkA-4mwfA:
5.14
1gmkB-4mwfA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		3 ALA A 119
VAL A 115
TRP A 116
 None
 1.01A 1gmkA-4nbrA:
undetectable
1gmkB-4nbrA:
undetectable		 1gmkA-4nbrA:
5.74
1gmkB-4nbrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npr XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE GH12

(Aspergillus
niveus) 		PF01670
(Glyco_hydro_12) 		3 ALA A 216
VAL A 116
TRP A 137
 None
 1.02A 1gmkA-4nprA:
undetectable
1gmkB-4nprA:
undetectable		 1gmkA-4nprA:
5.71
1gmkB-4nprA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		3 ALA A 173
VAL A   6
TRP A 275
 None
 1.01A 1gmkA-4o48A:
undetectable
1gmkB-4o48A:
undetectable		 1gmkA-4o48A:
3.68
1gmkB-4o48A:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		3 ALA A 441
VAL A 443
TRP A 398
 None
 0.81A 1gmkA-4p3iA:
undetectable
1gmkB-4p3iA:
undetectable		 1gmkA-4p3iA:
3.07
1gmkB-4p3iA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		3 ALA A 507
VAL A 503
TRP A 472
 None
 0.90A 1gmkA-4pljA:
undetectable
1gmkB-4pljA:
undetectable		 1gmkA-4pljA:
16.07
1gmkB-4pljA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		3 ALA A 190
VAL A 170
TRP A 134
 None
 0.91A 1gmkA-4ptxA:
undetectable
1gmkB-4ptxA:
undetectable		 1gmkA-4ptxA:
2.50
1gmkB-4ptxA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		3 ALA A 302
VAL A 297
TRP A 307
 None
 0.97A 1gmkA-4rkcA:
undetectable
1gmkB-4rkcA:
undetectable		 1gmkA-4rkcA:
2.62
1gmkB-4rkcA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF00155
(Aminotran_1_2) 		3 ALA A  46
VAL A 285
TRP A 298
 None
 0.97A 1gmkA-4w5kA:
undetectable
1gmkB-4w5kA:
undetectable		 1gmkA-4w5kA:
3.61
1gmkB-4w5kA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		3 ALA A 302
VAL A 297
TRP A 307
 None
 0.98A 1gmkA-4wd2A:
undetectable
1gmkB-4wd2A:
undetectable		 1gmkA-4wd2A:
3.93
1gmkB-4wd2A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 ALA A  59
VAL A 165
TRP A  11
 None
 0.90A 1gmkA-4x0oA:
undetectable
1gmkB-4x0oA:
undetectable		 1gmkA-4x0oA:
3.51
1gmkB-4x0oA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 ALA A  60
VAL A 165
TRP A  11
 None
 0.81A 1gmkA-4x0oA:
undetectable
1gmkB-4x0oA:
undetectable		 1gmkA-4x0oA:
3.51
1gmkB-4x0oA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 ALA A  78
VAL A 142
TRP A 134
 None
 0.95A 1gmkA-4xhbA:
undetectable
1gmkB-4xhbA:
undetectable		 1gmkA-4xhbA:
1.92
1gmkB-4xhbA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Mus musculus) 		PF03061
(4HBT) 		3 ALA A 162
VAL A 142
TRP A 165
 None
 1.02A 1gmkA-4zv3A:
undetectable
1gmkB-4zv3A:
undetectable		 1gmkA-4zv3A:
3.73
1gmkB-4zv3A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5agt LEUCINE--TRNA LIGASE

(Mycobacterium
tuberculosis) 		PF13603
(tRNA-synt_1_2) 		3 ALA A 367
VAL A 369
TRP A 365
 None
 1.02A 1gmkA-5agtA:
undetectable
1gmkB-5agtA:
undetectable		 1gmkA-5agtA:
8.70
1gmkB-5agtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c08 1E6 TCR ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ALA D 183
VAL D 133
TRP D 176
 None
 0.78A 1gmkA-5c08D:
undetectable
1gmkB-5c08D:
undetectable		 1gmkA-5c08D:
5.75
1gmkB-5c08D:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c30 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF02026
(RyR) 		3 ALA A1002
VAL A 995
TRP A1005
 None
 0.95A 1gmkA-5c30A:
undetectable
1gmkB-5c30A:
undetectable		 1gmkA-5c30A:
5.56
1gmkB-5c30A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc8 THIAMINE-MONOPHOSPHA
TE KINASE

(Acinetobacter
baumannii) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ALA A 131
VAL A  39
TRP A 134
 None
 0.96A 1gmkA-5cc8A:
undetectable
1gmkB-5cc8A:
undetectable		 1gmkA-5cc8A:
5.83
1gmkB-5cc8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlm HEAVY CHAIN OF
MONOCLONAL ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ALA H  33
VAL H  96
TRP H  36
 None
 0.90A 1gmkA-5dlmH:
undetectable
1gmkB-5dlmH:
undetectable		 1gmkA-5dlmH:
13.04
1gmkB-5dlmH:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 ALA A 159
VAL A 172
TRP A 152
 None
 0.57A 1gmkA-5e5uA:
undetectable
1gmkB-5e5uA:
undetectable		 1gmkA-5e5uA:
5.08
1gmkB-5e5uA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h98 GEOBACTER
METALLIREDUCENS
SMUG1

(Geobacter
metallireducens) 		no annotation 3 ALA A  75
VAL A  77
TRP A 115
 None
 0.97A 1gmkA-5h98A:
undetectable
1gmkB-5h98A:
undetectable		 1gmkA-5h98A:
9.24
1gmkB-5h98A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ALA H  33
VAL H  93
TRP H  36
 None
 0.70A 1gmkA-5ihuH:
undetectable
1gmkB-5ihuH:
undetectable		 1gmkA-5ihuH:
5.56
1gmkB-5ihuH:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j74 SCFV AM2.2

(Homo sapiens) 		PF07686
(V-set) 		3 ALA A  33
VAL A  97
TRP A  36
 None
6GN  A 302 ( 4.7A)
None
 0.95A 1gmkA-5j74A:
undetectable
1gmkB-5j74A:
undetectable		 1gmkA-5j74A:
4.26
1gmkB-5j74A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		3 ALA A 249
VAL A 251
TRP A 223
 None
 0.96A 1gmkA-5jzbA:
undetectable
1gmkB-5jzbA:
undetectable		 1gmkA-5jzbA:
5.31
1gmkB-5jzbA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 ALA B 478
VAL B 472
TRP B 473
 None
 1.02A 1gmkA-5kohB:
undetectable
1gmkB-5kohB:
undetectable		 1gmkA-5kohB:
3.10
1gmkB-5kohB:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		3 ALA A 313
VAL A 361
TRP A 440
 None
 1.02A 1gmkA-5l9wA:
undetectable
1gmkB-5l9wA:
undetectable		 1gmkA-5l9wA:
2.05
1gmkB-5l9wA:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		3 ALA A 158
VAL A 127
TRP A 125
 None
 0.98A 1gmkA-5ly3A:
undetectable
1gmkB-5ly3A:
undetectable		 1gmkA-5ly3A:
3.57
1gmkB-5ly3A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		3 ALA A 219
VAL A 221
TRP A 210
 None
 1.01A 1gmkA-5m58A:
undetectable
1gmkB-5m58A:
undetectable		 1gmkA-5m58A:
7.91
1gmkB-5m58A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vig FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 3 ALA H  33
VAL H  93
TRP H  36
 None
 0.94A 1gmkA-5vigH:
undetectable
1gmkB-5vigH:
undetectable		 1gmkA-5vigH:
7.45
1gmkB-5vigH:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsx CHITINASE

(Thermococcus
chitonophagus) 		no annotation 3 ALA A 646
VAL A 680
TRP A 682
 None
 1.02A 1gmkA-5xsxA:
undetectable
1gmkB-5xsxA:
undetectable		 1gmkA-5xsxA:
undetectable
1gmkB-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 3 ALA A  54
VAL A  44
TRP A  46
 None
 1.02A 1gmkA-5zmyA:
undetectable
1gmkB-5zmyA:
undetectable		 1gmkA-5zmyA:
undetectable
1gmkB-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 3
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 ALA 3 282
VAL 3 284
TRP A 368
 None
 0.94A 1gmkA-6c263:
undetectable
1gmkB-6c263:
undetectable		 1gmkA-6c263:
undetectable
1gmkB-6c263:
undetectable