SIMILAR PATTERNS OF AMINO ACIDS FOR 1GM7_B_PNNB1577

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		5 PHE B  24
SER B  67
ALA B  69
PHE B  71
ILE B 177
 None
 0.51A 1gm7A-1cp9B:
0.0
1gm7B-1cp9B:
57.4		 1gm7A-1cp9B:
18.70
1gm7B-1cp9B:
63.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		5 SER B   1
PHE B  24
ALA B  69
PHE B  71
ILE B 177
 None
 0.23A 1gm7A-1cp9B:
0.0
1gm7B-1cp9B:
57.4		 1gm7A-1cp9B:
18.70
1gm7B-1cp9B:
63.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 SER A 151
SER A 163
ALA A 158
ILE A 159
 None
 1.11A 1gm7A-1cwuA:
0.0
1gm7B-1cwuA:
0.0		 1gm7A-1cwuA:
22.44
1gm7B-1cwuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 SER A  66
ALA A  81
PHE A  95
ILE A  80
 None
 1.16A 1gm7A-1eizA:
undetectable
1gm7B-1eizA:
undetectable		 1gm7A-1eizA:
21.80
1gm7B-1eizA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Staphylococcus
aureus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 SER A  82
PHE A 136
ALA A 147
ILE A 144
 FAD  A 401 (-2.4A)
None
FAD  A 401 (-4.0A)
None
 1.16A 1gm7A-1hskA:
undetectable
1gm7B-1hskA:
0.0		 1gm7A-1hskA:
20.24
1gm7B-1hskA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 PHE A 634
ALA A 631
PHE A 581
ILE A 550
 None
 1.09A 1gm7A-1ji6A:
0.3
1gm7B-1ji6A:
0.0		 1gm7A-1ji6A:
17.75
1gm7B-1ji6A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		5 SER B   1
SER B  67
ALA B  69
PHE B  71
ILE B 177
 GRO  B 601 (-2.3A)
GRO  B 601 (-4.6A)
GRO  B 601 (-3.0A)
None
GRO  B 601 ( 4.4A)
 0.43A 1gm7A-1k5sB:
0.0
1gm7B-1k5sB:
60.5		 1gm7A-1k5sB:
16.67
1gm7B-1k5sB:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 SER A 102
ALA A  89
PHE A  90
ILE A  52
 None
 1.10A 1gm7A-1mc3A:
0.0
1gm7B-1mc3A:
0.0		 1gm7A-1mc3A:
18.95
1gm7B-1mc3A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 SER A 457
SER A 376
ALA A 371
ILE A 368
 None
 1.05A 1gm7A-1mt5A:
0.0
1gm7B-1mt5A:
0.0		 1gm7A-1mt5A:
17.05
1gm7B-1mt5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 SER A 177
ALA A 174
PHE A 152
ILE A 195
 None
 1.16A 1gm7A-1o12A:
0.0
1gm7B-1o12A:
undetectable		 1gm7A-1o12A:
19.53
1gm7B-1o12A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohq IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		4 MET A  34
PHE A 109
ALA A  24
ILE A  29
 None
 1.17A 1gm7A-1ohqA:
undetectable
1gm7B-1ohqA:
undetectable		 1gm7A-1ohqA:
21.00
1gm7B-1ohqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		4 SER A   2
SER A  59
ALA A  61
ILE A   9
 None
 0.99A 1gm7A-1pmiA:
undetectable
1gm7B-1pmiA:
undetectable		 1gm7A-1pmiA:
20.54
1gm7B-1pmiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F
CYTOCHROME B6F
COMPLEX SUBUNIT PETL
CYTOCHROME B6F
COMPLEX SUBUNIT PETN

(Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
PF05115
(PetL)
PF03742
(PetN) 		4 SER L   6
ALA N  79
PHE A 259
ILE N  75
 None
 1.07A 1gm7A-1q90L:
undetectable
1gm7B-1q90L:
undetectable		 1gm7A-1q90L:
12.00
1gm7B-1q90L:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		4 SER A 152
ALA A 169
PHE A 270
ILE A 185
 None
 1.11A 1gm7A-1r5jA:
undetectable
1gm7B-1r5jA:
undetectable		 1gm7A-1r5jA:
22.49
1gm7B-1r5jA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0s CHEMOTAXIS PROTEIN
CHEA
CHEMOTAXIS PROTEIN
CHEY

(Thermotoga
maritima;
Thermotoga
maritima) 		PF07194
(P2)
PF00072
(Response_reg) 		4 SER Y  82
ALA A 194
PHE Y 101
ILE Y  91
 None
 1.02A 1gm7A-1u0sY:
undetectable
1gm7B-1u0sY:
undetectable		 1gm7A-1u0sY:
22.38
1gm7B-1u0sY:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 MET A 194
SER A 153
ALA A 182
ILE A 185
 None
None
HPD  A 801 (-3.2A)
None
 0.83A 1gm7A-1ub3A:
undetectable
1gm7B-1ub3A:
undetectable		 1gm7A-1ub3A:
21.72
1gm7B-1ub3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 PHE A 147
ALA A 137
PHE A 238
ILE A 152
 None
AMP  A1002 (-3.6A)
AMP  A1002 (-4.5A)
None
 1.03A 1gm7A-1w0hA:
undetectable
1gm7B-1w0hA:
undetectable		 1gm7A-1w0hA:
18.80
1gm7B-1w0hA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 SER A  72
SER A  86
SER A  91
ILE A  92
 None
 0.91A 1gm7A-1we0A:
undetectable
1gm7B-1we0A:
undetectable		 1gm7A-1we0A:
20.81
1gm7B-1we0A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH) 		4 SER A 144
ALA A 173
PHE A  53
ILE A 172
 None
 1.16A 1gm7A-1wpnA:
undetectable
1gm7B-1wpnA:
undetectable		 1gm7A-1wpnA:
21.82
1gm7B-1wpnA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4o SPLICING FACTOR 4

(Mus musculus) 		PF01805
(Surp) 		4 PHE A  51
ALA A  25
PHE A  70
ILE A  28
 None
 1.14A 1gm7A-1x4oA:
undetectable
1gm7B-1x4oA:
undetectable		 1gm7A-1x4oA:
17.31
1gm7B-1x4oA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydn HYDROXYMETHYLGLUTARY
L-COA LYASE

(Brucella
melitensis) 		PF00682
(HMGL-like) 		4 SER A 141
SER A 107
ALA A 102
ILE A 115
 None
 1.11A 1gm7A-1ydnA:
undetectable
1gm7B-1ydnA:
undetectable		 1gm7A-1ydnA:
21.58
1gm7B-1ydnA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		4 SER A 155
ALA A 187
PHE A 157
ILE A 185
 None
 1.08A 1gm7A-1yw4A:
undetectable
1gm7B-1yw4A:
undetectable		 1gm7A-1yw4A:
21.25
1gm7B-1yw4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1

(Bacteroides
thetaiotaomicron) 		no annotation 4 MET A 269
ALA A   5
PHE A  63
ILE A   4
 None
 1.10A 1gm7A-1zxoA:
undetectable
1gm7B-1zxoA:
1.4		 1gm7A-1zxoA:
19.51
1gm7B-1zxoA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		4 SER A 134
ALA A  28
PHE A  97
ILE A  93
 None
 1.12A 1gm7A-2bfrA:
undetectable
1gm7B-2bfrA:
undetectable		 1gm7A-2bfrA:
18.91
1gm7B-2bfrA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 225
SER A 287
PHE A 414
ILE A 420
 None
 1.17A 1gm7A-2bg9A:
undetectable
1gm7B-2bg9A:
undetectable		 1gm7A-2bg9A:
20.00
1gm7B-2bg9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 SER A 156
ALA A 188
PHE A 178
ILE A 187
 None
 1.04A 1gm7A-2ftwA:
undetectable
1gm7B-2ftwA:
undetectable		 1gm7A-2ftwA:
17.56
1gm7B-2ftwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE

(Deinococcus
radiodurans) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 MET A 106
SER A 121
ALA A 123
ILE A 122
 None
 1.15A 1gm7A-2hz7A:
undetectable
1gm7B-2hz7A:
undetectable		 1gm7A-2hz7A:
13.48
1gm7B-2hz7A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		4 SER A 250
ALA A 246
PHE A 242
ILE A 247
 None
None
None
ADP  A 301 (-4.3A)
 1.02A 1gm7A-2i5bA:
undetectable
1gm7B-2i5bA:
1.1		 1gm7A-2i5bA:
22.68
1gm7B-2i5bA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3t FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		4 SER A2455
PHE A2450
SER A2510
ILE A2507
 None
 0.83A 1gm7A-2k3tA:
undetectable
1gm7B-2k3tA:
undetectable		 1gm7A-2k3tA:
19.62
1gm7B-2k3tA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 292
SER A 141
PHE A 192
ILE A 139
 None
 1.15A 1gm7A-2ps2A:
undetectable
1gm7B-2ps2A:
undetectable		 1gm7A-2ps2A:
18.18
1gm7B-2ps2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 PHE A 181
ALA A 176
PHE A 137
ILE A 173
 None
 1.08A 1gm7A-2pyjA:
undetectable
1gm7B-2pyjA:
undetectable		 1gm7A-2pyjA:
16.67
1gm7B-2pyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 PHE A 122
SER A 343
ALA A  52
PHE A 295
 None
 1.05A 1gm7A-2x98A:
undetectable
1gm7B-2x98A:
0.2		 1gm7A-2x98A:
19.05
1gm7B-2x98A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 PHE B  39
SER B  22
ALA B  20
ILE B  19
 None
 1.02A 1gm7A-2xdqB:
undetectable
1gm7B-2xdqB:
undetectable		 1gm7A-2xdqB:
17.08
1gm7B-2xdqB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 MET A 322
ALA A 376
PHE A 315
ILE A 311
 None
 0.95A 1gm7A-2xijA:
undetectable
1gm7B-2xijA:
undetectable		 1gm7A-2xijA:
15.16
1gm7B-2xijA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yug PROTEIN FRG1

(Mus musculus) 		PF06229
(FRG1) 		4 PHE A 109
ALA A 115
PHE A 123
ILE A 145
 None
 1.10A 1gm7A-2yugA:
undetectable
1gm7B-2yugA:
undetectable		 1gm7A-2yugA:
22.22
1gm7B-2yugA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		4 MET A 252
SER A  77
SER A  70
ILE A  71
 None
 1.03A 1gm7A-3aczA:
undetectable
1gm7B-3aczA:
undetectable		 1gm7A-3aczA:
17.63
1gm7B-3aczA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajz ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		4 PHE A 106
ALA A  40
PHE A 115
ILE A  39
 None
 0.99A 1gm7A-3ajzA:
undetectable
1gm7B-3ajzA:
undetectable		 1gm7A-3ajzA:
22.68
1gm7B-3ajzA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomyces
pombe) 		PF03876
(SHS2_Rpb7-N)
PF08292
(RNA_pol_Rbc25) 		4 MET B 113
SER B 156
ALA B 189
ILE B 188
 None
 1.14A 1gm7A-3ayhB:
undetectable
1gm7B-3ayhB:
undetectable		 1gm7A-3ayhB:
20.26
1gm7B-3ayhB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 PHE A 425
ALA A 542
PHE A 546
ILE A 541
 None
 0.97A 1gm7A-3ce2A:
undetectable
1gm7B-3ce2A:
undetectable		 1gm7A-3ce2A:
15.90
1gm7B-3ce2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B
DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N)
PF08996
(zf-DNA_Pol) 		4 MET A 250
SER A 493
ALA A 496
ILE B1338
 None
 1.16A 1gm7A-3floA:
undetectable
1gm7B-3floA:
undetectable		 1gm7A-3floA:
18.00
1gm7B-3floA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		4 MET A 243
SER A 226
ALA A 219
ILE A 218
 None
 0.86A 1gm7A-3hi0A:
undetectable
1gm7B-3hi0A:
undetectable		 1gm7A-3hi0A:
17.61
1gm7B-3hi0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 SER A 210
PHE A 116
SER A 223
ILE A 220
 None
 1.02A 1gm7A-3ifsA:
undetectable
1gm7B-3ifsA:
undetectable		 1gm7A-3ifsA:
18.99
1gm7B-3ifsA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 MET A 215
SER A 314
PHE A 209
ILE A 211
 None
 1.00A 1gm7A-3j3iA:
undetectable
1gm7B-3j3iA:
undetectable		 1gm7A-3j3iA:
12.72
1gm7B-3j3iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcm U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 SER B 442
SER B 182
ALA B 180
ILE B 224
 None
 1.05A 1gm7A-3jcmB:
undetectable
1gm7B-3jcmB:
undetectable		 1gm7A-3jcmB:
16.34
1gm7B-3jcmB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN

(Homo sapiens) 		PF00516
(GP120) 		4 SER A  56
SER A 115
PHE A 210
ILE A 108
 None
 0.90A 1gm7A-3jwoA:
undetectable
1gm7B-3jwoA:
undetectable		 1gm7A-3jwoA:
18.03
1gm7B-3jwoA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 MET A 143
SER B   1
PHE B  24
ALA B  69
 None
 0.49A 1gm7A-3ml0A:
22.1
1gm7B-3ml0A:
undetectable		 1gm7A-3ml0A:
46.01
1gm7B-3ml0A:
16.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 MET A 143
SER B   1
PHE B  24
ILE B 177
 None
 0.56A 1gm7A-3ml0A:
22.1
1gm7B-3ml0A:
undetectable		 1gm7A-3ml0A:
46.01
1gm7B-3ml0A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		4 MET A 197
SER A 156
ALA A 185
ILE A 188
 None
 0.87A 1gm7A-3ngjA:
undetectable
1gm7B-3ngjA:
undetectable		 1gm7A-3ngjA:
19.67
1gm7B-3ngjA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 SER A  56
SER A 115
PHE A 210
ILE A 108
 None
 0.94A 1gm7A-3tgqA:
undetectable
1gm7B-3tgqA:
undetectable		 1gm7A-3tgqA:
21.82
1gm7B-3tgqA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 SER A 302
PHE A  48
SER A  52
ILE A 119
 None
 0.89A 1gm7A-3thcA:
undetectable
1gm7B-3thcA:
undetectable		 1gm7A-3thcA:
15.02
1gm7B-3thcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		4 SER A  42
SER A  71
PHE A  74
ALA A 323
 None
 1.05A 1gm7A-3wecA:
undetectable
1gm7B-3wecA:
undetectable		 1gm7A-3wecA:
19.05
1gm7B-3wecA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdp NUCLEOCAPSID PROTEIN

(Influenza A
virus) 		PF00506
(Flu_NP) 		4 SER A 274
ALA A 387
PHE A 304
ILE A 388
 None
 1.07A 1gm7A-3zdpA:
undetectable
1gm7B-3zdpA:
undetectable		 1gm7A-3zdpA:
17.72
1gm7B-3zdpA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 SER A 340
SER A 235
ALA A 231
PHE A 348
 CL  A 506 ( 4.1A)
None
None
None
 1.02A 1gm7A-3zx2A:
undetectable
1gm7B-3zx2A:
undetectable		 1gm7A-3zx2A:
18.14
1gm7B-3zx2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		4 PHE A  67
SER A 225
ALA A 229
ILE A 115
 None
 1.16A 1gm7A-3zxyA:
undetectable
1gm7B-3zxyA:
undetectable		 1gm7A-3zxyA:
23.47
1gm7B-3zxyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 SER A 120
ALA A  86
PHE A  74
ILE A  87
 None
 1.01A 1gm7A-4amfA:
undetectable
1gm7B-4amfA:
undetectable		 1gm7A-4amfA:
16.58
1gm7B-4amfA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bax GLUTAMINE SYNTHETASE

(Streptomyces
coelicolor) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 MET A 245
SER A 258
ALA A 256
ILE A 317
 None
 1.05A 1gm7A-4baxA:
undetectable
1gm7B-4baxA:
undetectable		 1gm7A-4baxA:
20.75
1gm7B-4baxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 SER B3026
ALA B2943
PHE B3098
ILE B2942
 None
 1.15A 1gm7A-4bedB:
undetectable
1gm7B-4bedB:
undetectable		 1gm7A-4bedB:
8.44
1gm7B-4bedB:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 PHE A 225
SER A 287
PHE A 414
ILE A 420
 None
 1.17A 1gm7A-4booA:
undetectable
1gm7B-4booA:
undetectable		 1gm7A-4booA:
16.34
1gm7B-4booA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		4 SER A  44
SER A 341
ALA A 327
ILE A 160
 None
 1.16A 1gm7A-4c41A:
undetectable
1gm7B-4c41A:
undetectable		 1gm7A-4c41A:
20.49
1gm7B-4c41A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		4 SER A  72
ALA A 244
PHE A 124
ILE A 247
 None
 0.96A 1gm7A-4g1uA:
undetectable
1gm7B-4g1uA:
2.1		 1gm7A-4g1uA:
19.67
1gm7B-4g1uA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gud IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISH

(Vibrio cholerae) 		PF00117
(GATase) 		4 MET A  82
SER A 171
ALA A 173
ILE A 174
 None
 0.99A 1gm7A-4gudA:
undetectable
1gm7B-4gudA:
undetectable		 1gm7A-4gudA:
21.43
1gm7B-4gudA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0f LAMININ-BINDING
SURFACE PROTEIN

(Streptococcus
agalactiae) 		PF01297
(ZnuA) 		4 MET A  42
ALA A 154
PHE A 179
ILE A 157
 None
 1.01A 1gm7A-4h0fA:
undetectable
1gm7B-4h0fA:
undetectable		 1gm7A-4h0fA:
22.55
1gm7B-4h0fA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE

(Planktothrix
agardhii) 		PF00082
(Peptidase_S8) 		4 PHE A  70
SER A 228
ALA A 232
ILE A 118
 None
 1.12A 1gm7A-4h6wA:
undetectable
1gm7B-4h6wA:
undetectable		 1gm7A-4h6wA:
21.90
1gm7B-4h6wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		4 SER A  29
SER A  76
ALA A  72
ILE A  73
 None
None
ACT  A 406 (-3.6A)
None
 1.07A 1gm7A-4hdtA:
undetectable
1gm7B-4hdtA:
undetectable		 1gm7A-4hdtA:
22.25
1gm7B-4hdtA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i62 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING
PROTEIN, PUTATIVE

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 SER A 175
PHE A  48
SER A 109
ILE A 159
 None
ARG  A 301 (-3.4A)
ARG  A 301 (-2.8A)
ARG  A 301 (-4.0A)
 1.08A 1gm7A-4i62A:
undetectable
1gm7B-4i62A:
undetectable		 1gm7A-4i62A:
21.75
1gm7B-4i62A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 SER A 345
PHE A 242
ALA A 209
ILE A 353
 None
 0.90A 1gm7A-4j72A:
1.6
1gm7B-4j72A:
undetectable		 1gm7A-4j72A:
17.74
1gm7B-4j72A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		4 PHE A 396
ALA A 317
PHE A 318
ILE A 315
 None
 1.00A 1gm7A-4j9tA:
undetectable
1gm7B-4j9tA:
undetectable		 1gm7A-4j9tA:
18.96
1gm7B-4j9tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 SER A  95
PHE A 222
ALA A 195
PHE A 193
 None
None
ZN  A 401 ( 4.7A)
None
 1.10A 1gm7A-4lanA:
undetectable
1gm7B-4lanA:
undetectable		 1gm7A-4lanA:
19.74
1gm7B-4lanA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		4 PHE A  90
ALA A  59
PHE A  44
ILE A  20
 None
 1.09A 1gm7A-4lxiA:
undetectable
1gm7B-4lxiA:
undetectable		 1gm7A-4lxiA:
23.02
1gm7B-4lxiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		4 SER A  81
ALA A 184
PHE A  86
ILE A 181
 None
 1.08A 1gm7A-4p6bA:
undetectable
1gm7B-4p6bA:
undetectable		 1gm7A-4p6bA:
19.59
1gm7B-4p6bA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		6 MET A 142
SER A 149
PHE B  24
SER B  67
ALA B  69
ILE B 177
 None
 0.54A 1gm7A-4pelA:
25.6
1gm7B-4pelA:
undetectable		 1gm7A-4pelA:
72.34
1gm7B-4pelA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		6 MET A 142
SER A 149
SER B  67
ALA B  69
PHE B  71
ILE B 177
 None
 0.48A 1gm7A-4pelA:
25.6
1gm7B-4pelA:
undetectable		 1gm7A-4pelA:
72.34
1gm7B-4pelA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 SER A 205
PHE A 133
ALA A 156
PHE A 178
 None
 0.97A 1gm7A-4tz5A:
undetectable
1gm7B-4tz5A:
undetectable		 1gm7A-4tz5A:
15.45
1gm7B-4tz5A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 4 SER A 205
SER A 120
ALA A 156
PHE A 178
 None
 0.85A 1gm7A-4tz5A:
undetectable
1gm7B-4tz5A:
undetectable		 1gm7A-4tz5A:
15.45
1gm7B-4tz5A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 MET A  84
ALA A 288
PHE A 114
ILE A 292
 None
 1.17A 1gm7A-4xehA:
undetectable
1gm7B-4xehA:
undetectable		 1gm7A-4xehA:
21.01
1gm7B-4xehA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 SER A 259
ALA A 278
PHE A 294
ILE A 261
 None
 1.12A 1gm7A-4xhbA:
undetectable
1gm7B-4xhbA:
undetectable		 1gm7A-4xhbA:
16.72
1gm7B-4xhbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 SER G  56
SER G 115
PHE G 210
ILE G 108
 None
 0.85A 1gm7A-4ydiG:
undetectable
1gm7B-4ydiG:
undetectable		 1gm7A-4ydiG:
17.78
1gm7B-4ydiG:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 MET A  84
ALA A 288
PHE A 114
ILE A 292
 None
 1.14A 1gm7A-5e4rA:
undetectable
1gm7B-5e4rA:
undetectable		 1gm7A-5e4rA:
17.60
1gm7B-5e4rA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 SER A 170
ALA A 174
PHE A 178
ILE A 137
 None
 1.13A 1gm7A-5hmpA:
undetectable
1gm7B-5hmpA:
undetectable		 1gm7A-5hmpA:
14.23
1gm7B-5hmpA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 SER A 243
ALA A 113
PHE A 117
ILE A 112
 None
 1.16A 1gm7A-5hyhA:
undetectable
1gm7B-5hyhA:
undetectable		 1gm7A-5hyhA:
18.93
1gm7B-5hyhA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6u PROTEIN SIDEKICK-1

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 SER A 244
SER A 137
ALA A 141
ILE A 140
 None
 1.14A 1gm7A-5k6uA:
undetectable
1gm7B-5k6uA:
undetectable		 1gm7A-5k6uA:
18.49
1gm7B-5k6uA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 SER b  68
SER b  18
ALA b 469
ILE b 470
 None
 1.12A 1gm7A-5l9wb:
undetectable
1gm7B-5l9wb:
undetectable		 1gm7A-5l9wb:
14.55
1gm7B-5l9wb:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf5 MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 SER A 472
PHE A 444
SER A 419
ILE A 415
 None
 1.11A 1gm7A-5lf5A:
undetectable
1gm7B-5lf5A:
undetectable		 1gm7A-5lf5A:
16.19
1gm7B-5lf5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 SER A1245
SER A1545
ALA A1547
PHE A1347
 None
 1.05A 1gm7A-5m59A:
undetectable
1gm7B-5m59A:
1.4		 1gm7A-5m59A:
9.21
1gm7B-5m59A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 217
ALA A 288
PHE A 284
ILE A 289
 None
 0.79A 1gm7A-5na7A:
undetectable
1gm7B-5na7A:
2.6		 1gm7A-5na7A:
14.61
1gm7B-5na7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		4 SER C 163
SER C 500
PHE C 120
ALA C 496
 ANP  C 602 (-3.6A)
None
None
None
 0.87A 1gm7A-5nd7C:
undetectable
1gm7B-5nd7C:
undetectable		 1gm7A-5nd7C:
18.09
1gm7B-5nd7C:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 SER A 358
SER A 317
ALA A 315
ILE A 244
 None
EDO  A 625 ( 4.5A)
None
None
 0.95A 1gm7A-5nqaA:
undetectable
1gm7B-5nqaA:
undetectable		 1gm7A-5nqaA:
undetectable
1gm7B-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L23
50S RIBOSOMAL
PROTEIN L29

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF00276
(Ribosomal_L23)
PF00831
(Ribosomal_L29) 		4 SER U  37
PHE Z  30
ALA U  45
ILE U  46
 None
 0.98A 1gm7A-5o60U:
undetectable
1gm7B-5o60U:
undetectable		 1gm7A-5o60U:
17.59
1gm7B-5o60U:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 SER Y 702
ALA Y 698
PHE Y 686
ILE Y 697
 None
 1.09A 1gm7A-5svaY:
undetectable
1gm7B-5svaY:
undetectable		 1gm7A-5svaY:
14.93
1gm7B-5svaY:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1q N-ACETYLMURAMOYL-L-A
LANINE AMIDASE
DOMAIN-CONTAINING
PROTEIN
SAOUHSC_02979

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase)
PF05257
(CHAP) 		4 SER A 355
ALA A 349
PHE A 369
ILE A 350
 None
 1.03A 1gm7A-5t1qA:
undetectable
1gm7B-5t1qA:
undetectable		 1gm7A-5t1qA:
20.22
1gm7B-5t1qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t38 EVDMO1

(Micromonospora
carbonacea) 		PF13847
(Methyltransf_31) 		4 SER A 149
ALA A 125
PHE A  52
ILE A  58
 None
 1.16A 1gm7A-5t38A:
undetectable
1gm7B-5t38A:
undetectable		 1gm7A-5t38A:
22.03
1gm7B-5t38A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te4 HIV-1 CLADE G STRAIN
X2088 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 SER G  56
SER G 115
PHE G 210
ILE G 108
 None
 0.99A 1gm7A-5te4G:
undetectable
1gm7B-5te4G:
undetectable		 1gm7A-5te4G:
22.07
1gm7B-5te4G:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9z PHOSPHOGLYCEROL
TRANSFERASE

(Streptococcus
pyogenes) 		no annotation 4 SER A 607
ALA A 578
PHE A 601
ILE A 577
 None
 1.17A 1gm7A-5u9zA:
undetectable
1gm7B-5u9zA:
undetectable		 1gm7A-5u9zA:
undetectable
1gm7B-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wd8 LEM22

(Legionella
pneumophila) 		no annotation 4 SER A  63
SER A   7
ALA A   9
ILE A  58
 None
 0.99A 1gm7A-5wd8A:
undetectable
1gm7B-5wd8A:
undetectable		 1gm7A-5wd8A:
16.59
1gm7B-5wd8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		4 MET A  58
SER A  41
ALA A 106
ILE A 107
 None
 1.06A 1gm7A-5x9rA:
undetectable
1gm7B-5x9rA:
2.2		 1gm7A-5x9rA:
18.62
1gm7B-5x9rA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk2 DIACYLGLYCEROL
LIPASE

(Aspergillus
oryzae) 		no annotation 4 SER A  57
ALA A  76
PHE A  74
ILE A  84
 None
 1.16A 1gm7A-5xk2A:
undetectable
1gm7B-5xk2A:
undetectable		 1gm7A-5xk2A:
undetectable
1gm7B-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE

(Escherichia
coli) 		no annotation 4 SER A 182
SER A  10
ALA A  79
ILE A 111
 None
 1.11A 1gm7A-5z03A:
undetectable
1gm7B-5z03A:
undetectable		 1gm7A-5z03A:
undetectable
1gm7B-5z03A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 4 SER A  87
ALA A 128
PHE A 126
ILE A 129
 None
 1.14A 1gm7A-6b7kA:
undetectable
1gm7B-6b7kA:
undetectable		 1gm7A-6b7kA:
undetectable
1gm7B-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 SER B 731
ALA B 733
PHE B 741
ILE B 732
 None
 1.03A 1gm7A-6bywB:
undetectable
1gm7B-6bywB:
undetectable		 1gm7A-6bywB:
undetectable
1gm7B-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		4 SER G  46
ALA G   3
PHE E  29
ILE G   2
 None
 1.03A 1gm7A-6cfwG:
undetectable
1gm7B-6cfwG:
undetectable		 1gm7A-6cfwG:
undetectable
1gm7B-6cfwG:
undetectable