SIMILAR PATTERNS OF AMINO ACIDS FOR 1GHM_A_CEDA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		10 ALA A  69
SER A  70
LYS A  73
SER A 130
ASN A 132
ILE A 167
LYS A 234
SER A 235
GLY A 236
ARG A 244
 None
 0.34A 1ghmA-1alqA:
35.2		 1ghmA-1alqA:
82.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		7 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 220
 None
 0.91A 1ghmA-1bsgA:
37.4		 1ghmA-1bsgA:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
 0.40A 1ghmA-1bueA:
37.0		 1ghmA-1bueA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
 0.48A 1ghmA-1dy6A:
37.0		 1ghmA-1dy6A:
35.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 SO4  A 500 (-3.1A)
None
SO4  A 500 (-2.6A)
None
SO4  A 500 (-3.2A)
SO4  A 500 (-3.5A)
 0.26A 1ghmA-1e25A:
29.9		 1ghmA-1e25A:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g68 BETA-LACTAMASE PSE-4

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		7 SER A  70
LYS A  73
SER A 130
ASN A 132
SER A 235
GLY A 236
ARG A 244
 SO4  A 400 (-2.9A)
SO4  A 400 ( 4.7A)
SO4  A 400 (-2.7A)
None
SO4  A 400 (-3.5A)
SO4  A 400 (-3.0A)
SO4  A 400 ( 4.6A)
 0.48A 1ghmA-1g68A:
35.5		 1ghmA-1g68A:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		7 ALA A  69
SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
MES  A1000 (-3.1A)
None
MES  A1000 (-2.7A)
None
MES  A1000 (-2.9A)
MES  A1000 (-3.1A)
 0.39A 1ghmA-1hzoA:
38.3		 1ghmA-1hzoA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		8 ALA A  69
SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 CFX  A1300 (-3.5A)
CFX  A1300 (-1.3A)
CFX  A1300 (-2.6A)
CFX  A1300 (-3.1A)
CFX  A1300 (-3.0A)
CFX  A1300 ( 3.9A)
CFX  A1300 (-3.3A)
CFX  A1300 (-3.5A)
 0.27A 1ghmA-1i2wA:
41.1		 1ghmA-1i2wA:
40.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica) 		PF00905
(Transpeptidase) 		6 ALA A  66
SER A  67
SER A 115
LYS A 205
GLY A 207
ARG A 244
 None
KCX  A  70 ( 2.7A)
FMT  A 401 (-2.4A)
FMT  A 401 ( 3.8A)
FMT  A 401 (-3.6A)
FMT  A 401 (-2.6A)
 0.72A 1ghmA-1k38A:
17.5		 1ghmA-1k38A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 SO4  A1002 (-2.9A)
SO4  A1002 ( 4.9A)
SO4  A1002 (-3.1A)
None
SO4  A1002 (-3.6A)
SO4  A1002 (-3.2A)
 0.26A 1ghmA-1n4oA:
36.3		 1ghmA-1n4oA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		7 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 EPE  A 400 (-3.7A)
None
EPE  A 400 (-2.5A)
None
EPE  A 400 (-3.1A)
EPE  A 400 (-3.1A)
MA4  A 310 ( 3.8A)
 0.66A 1ghmA-1n9bA:
32.4		 1ghmA-1n9bA:
29.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrf REGULATORY PROTEIN
BLAR1

(Bacillus
licheniformis) 		PF00905
(Transpeptidase) 		7 ALA A 401
SER A 402
LYS A 405
TYR A 434
SER A 450
LYS A 539
GLY A 541
 None
 0.81A 1ghmA-1nrfA:
18.1		 1ghmA-1nrfA:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pio BETA-LACTAMASE

(Staphylococcus
aureus) 		PF13354
(Beta-lactamase2) 		11 ALA A  69
SER A  70
LYS A  73
TYR A 105
SER A 130
ASN A 132
ILE A 167
LYS A 234
SER A 235
GLY A 236
ARG A 244
 None
 0.68A 1ghmA-1pioA:
44.7		 1ghmA-1pioA:
98.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		6 SER A  66
LYS A  69
ASN A 117
LYS A 259
SER A 260
GLY A 261
 None
 0.69A 1ghmA-1u60A:
4.6		 1ghmA-1u60A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		8 ALA A  51
SER A  52
LYS A  55
TYR A 150
SER A 299
ASN A 301
LYS A 411
GLY A 413
 None
 0.64A 1ghmA-1w5dA:
20.2		 1ghmA-1w5dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		8 ALA A  55
SER A  56
LYS A  59
SER A 119
ASN A 121
LYS A 239
GLY A 241
ARG A 278
 None
SO4  A 464 (-3.4A)
None
SO4  A 464 (-3.4A)
None
SO4  A 464 (-3.5A)
SO4  A 464 ( 3.8A)
SO4  A 464 ( 4.1A)
 1.01A 1ghmA-1xp4A:
20.7		 1ghmA-1xp4A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		8 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
SER A 235
GLY A 236
ARG A 244
 None
 0.30A 1ghmA-1zg4A:
34.8		 1ghmA-1zg4A:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
 0.28A 1ghmA-2cc1A:
36.3		 1ghmA-2cc1A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		7 ALA A  61
SER A  62
LYS A  65
SER A 306
ASN A 308
LYS A 417
GLY A 419
 DGF  A 501 (-3.6A)
DGF  A 501 (-1.3A)
DGF  A 501 ( 4.0A)
DGF  A 501 (-3.3A)
DGF  A 501 (-3.0A)
None
DGF  A 501 (-3.4A)
 0.27A 1ghmA-2exaA:
17.8		 1ghmA-2exaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		7 ALA B 459
SER B 460
LYS B 463
SER B 516
ASN B 518
LYS B 651
GLY B 653
 None
 0.39A 1ghmA-2fffB:
16.0		 1ghmA-2fffB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		6 SER A 391
LYS A 394
SER A 439
ASN A 441
LYS A 528
GLY A 530
 GOL  A 604 ( 2.7A)
GOL  A 605 ( 3.9A)
GOL  A 604 (-2.6A)
GOL  A 605 (-2.8A)
GOL  A 604 (-2.9A)
GOL  A 605 ( 3.2A)
 0.40A 1ghmA-2iwbA:
17.5		 1ghmA-2iwbA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		7 ALA A  60
SER A  61
LYS A  64
SER A 122
ASN A 124
LYS A 219
GLY A 221
 None
 0.26A 1ghmA-2j7vA:
30.5		 1ghmA-2j7vA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jch PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		7 ALA A 459
SER A 460
LYS A 463
SER A 516
ASN A 518
LYS A 651
GLY A 653
 PL7  A1793 (-3.5A)
PL7  A1793 (-1.4A)
PL7  A1793 ( 4.0A)
PL7  A1793 (-3.0A)
PL7  A1793 (-3.2A)
PL7  A1793 ( 4.1A)
PL7  A1793 (-3.3A)
 0.58A 1ghmA-2jchA:
14.8		 1ghmA-2jchA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		6 SER A  65
LYS A  68
ASN A 116
LYS A 259
SER A 260
GLY A 261
 None
 0.41A 1ghmA-2pbyA:
13.2		 1ghmA-2pbyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 SER A 386
LYS A 389
SER A 443
ASN A 445
LYS A 615
GLY A 617
 None
 0.40A 1ghmA-2waeA:
14.3		 1ghmA-2waeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		6 ALA A  46
SER A  47
LYS A  50
SER A 109
LYS A 254
GLY A 256
 None
 0.30A 1ghmA-2wuqA:
27.4		 1ghmA-2wuqA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
 0.30A 1ghmA-2wyxA:
37.9		 1ghmA-2wyxA:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		7 SER B 337
LYS B 340
SER B 395
ASN B 397
LYS B 547
SER B 548
GLY B 549
 CDS  B 901 ( 1.3A)
CDS  B 901 ( 4.2A)
CDS  B 901 ( 3.2A)
CDS  B 901 ( 3.0A)
CDS  B 901 ( 3.9A)
CDS  B 901 ( 2.9A)
CDS  B 901 ( 3.4A)
 0.41A 1ghmA-2z2mB:
16.2		 1ghmA-2z2mB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		7 ALA A  68
SER A  69
LYS A  72
SER A 310
ASN A 312
LYS A 420
GLY A 422
 AIX  A 501 (-3.6A)
AIX  A 501 (-1.3A)
AIX  A 501 ( 4.0A)
AIX  A 501 (-2.8A)
AIX  A 501 (-3.3A)
AIX  A 501 ( 3.8A)
AIX  A 501 (-3.4A)
 0.39A 1ghmA-3a3iA:
20.6		 1ghmA-3a3iA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		6 ALA A  64
SER A  65
LYS A  68
SER A 128
ASN A 130
GLY A 233
 None
None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.5A)
 0.58A 1ghmA-3a3jA:
21.7		 1ghmA-3a3jA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agf GLUTAMINASE 1

(Bacillus
subtilis) 		PF04960
(Glutaminase) 		6 SER A  74
LYS A  77
ASN A 126
LYS A 268
SER A 269
GLY A 270
 None
 0.50A 1ghmA-3agfA:
4.2		 1ghmA-3agfA:
24.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 MER  A 301 (-1.3A)
MER  A 301 ( 3.8A)
MER  A 301 (-2.6A)
MER  A 301 (-3.2A)
MER  A 301 (-3.2A)
MER  A 301 (-3.0A)
 0.39A 1ghmA-3bfgA:
38.4		 1ghmA-3bfgA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3byd BETA-LACTAMASE OXY-1

(Klebsiella
oxytoca) 		PF13354
(Beta-lactamase2) 		6 SER A  73
LYS A  76
SER A 133
ASN A 135
LYS A 237
GLY A 239
 SO4  A 301 (-2.9A)
SO4  A 301 ( 4.9A)
SO4  A 301 (-2.8A)
None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.3A)
 0.22A 1ghmA-3bydA:
38.1		 1ghmA-3bydA:
33.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		7 ALA A 107
SER A 108
LYS A 111
SER A 169
ASN A 171
LYS A 257
GLY A 259
 None
NO3  A   1 (-2.9A)
NO3  A   1 (-3.5A)
None
NO3  A   1 ( 4.7A)
None
None
 0.28A 1ghmA-3cjmA:
25.5		 1ghmA-3cjmA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		7 SER A 398
LYS A 401
TYR A 437
SER A 454
ASN A 456
LYS A 583
GLY A 585
 SO4  A  26 (-2.7A)
SO4  A  26 ( 4.8A)
None
SO4  A  26 (-3.1A)
None
SO4  A  26 ( 4.2A)
SO4  A  26 (-3.3A)
 0.93A 1ghmA-3dwkA:
16.4		 1ghmA-3dwkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		7 ALA A  74
SER A  75
LYS A  78
SER A 139
ASN A 141
LYS A 259
GLY A 261
 CEW  A 501 ( 4.1A)
CEW  A 501 (-2.6A)
None
CEW  A 501 (-3.4A)
None
CEW  A 501 ( 4.4A)
CEW  A 501 (-3.1A)
 0.63A 1ghmA-3humA:
22.2		 1ghmA-3humA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		6 ALA C  71
SER C  72
SER C 120
LYS C 210
GLY C 212
ARG C 249
 None
KCX  C  75 ( 2.7A)
KCX  C  75 ( 3.5A)
KCX  C  75 ( 4.4A)
None
None
 0.64A 1ghmA-3if6C:
17.1		 1ghmA-3if6C:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		6 SER A  64
LYS A  67
ASN A 114
LYS A 258
SER A 259
GLY A 260
 GLU  A 500 (-2.6A)
GLU  A 500 ( 4.6A)
GLU  A 500 (-3.7A)
GLU  A 500 ( 4.7A)
None
GLU  A 500 ( 3.8A)
 0.81A 1ghmA-3ihaA:
12.5		 1ghmA-3ihaA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		6 SER A  85
LYS A  88
ASN A 145
LYS A 247
GLY A 249
ARG A 256
 EPE  A 305 (-3.4A)
None
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 (-3.7A)
 0.31A 1ghmA-3lezA:
39.6		 1ghmA-3lezA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		6 SER A  85
SER A 143
ASN A 145
LYS A 247
GLY A 249
ARG A 256
 EPE  A 305 (-3.4A)
EPE  A 305 (-2.5A)
None
EPE  A 305 (-3.1A)
EPE  A 305 (-3.4A)
EPE  A 305 (-3.7A)
 0.59A 1ghmA-3lezA:
39.6		 1ghmA-3lezA:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		7 ALA A  59
SER A  60
LYS A  63
SER A 115
ASN A 117
LYS A 220
GLY A 222
 CIT  A   1 ( 4.5A)
CIT  A   1 (-2.5A)
CIT  A   1 ( 4.4A)
CIT  A   1 (-2.8A)
None
CIT  A   1 ( 3.7A)
CIT  A   1 (-3.3A)
 0.27A 1ghmA-3mfdA:
21.7		 1ghmA-3mfdA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		6 SER A 389
LYS A 392
SER A 437
ASN A 439
LYS A 526
GLY A 528
 BOU  A 584 (-1.4A)
BOU  A 584 ( 3.9A)
BOU  A 584 (-2.8A)
BOU  A 584 (-3.5A)
BOU  A 584 (-3.3A)
BOU  A 584 (-3.7A)
 0.39A 1ghmA-3q7zA:
17.8		 1ghmA-3q7zA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		10 ALA A  69
SER A  70
LYS A  73
TYR A 105
SER A 130
ASN A 132
LYS A 234
SER A 235
GLY A 236
ARG A 244
 None
 0.49A 1ghmA-3qhyA:
40.8		 1ghmA-3qhyA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		6 ALA A  66
SER A  67
SER A 115
LYS A 205
GLY A 207
ARG A 250
 None
KCX  A  70 ( 2.7A)
KCX  A  70 ( 4.6A)
KCX  A  70 ( 4.7A)
None
SO4  A   4 (-3.4A)
 0.74A 1ghmA-3qnbA:
17.7		 1ghmA-3qnbA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		6 ALA A  58
SER A  59
LYS A  62
ASN A 158
LYS A 299
GLY A 301
 CIT  A 391 ( 4.1A)
CIT  A 391 (-2.5A)
CIT  A 391 ( 4.4A)
CIT  A 391 ( 4.7A)
CIT  A 391 ( 4.4A)
CIT  A 391 (-3.3A)
 0.37A 1ghmA-3rjuA:
6.1		 1ghmA-3rjuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 SER A 336
LYS A 339
SER A 390
ASN A 392
LYS A 525
GLY A 527
 None
 0.53A 1ghmA-3ue3A:
15.7		 1ghmA-3ue3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		6 SER A 222
LYS A 225
SER A 281
ASN A 283
LYS A 424
GLY A 426
 IM2  A 800 (-1.3A)
IM2  A 800 ( 4.5A)
IM2  A 800 (-3.0A)
IM2  A 800 (-3.3A)
IM2  A 800 ( 3.9A)
IM2  A 800 (-3.4A)
 0.48A 1ghmA-3upnA:
16.7		 1ghmA-3upnA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		7 ALA A  69
SER A  70
LYS A  73
SER A 251
ASN A 253
LYS A 357
GLY A 359
 TAU  A 501 (-3.4A)
TAU  A 501 (-1.5A)
TAU  A 501 ( 3.7A)
TAU  A 501 (-2.6A)
TAU  A 501 (-3.1A)
TAU  A 501 ( 4.3A)
TAU  A 501 (-3.5A)
 0.30A 1ghmA-3v39A:
17.7		 1ghmA-3v39A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 SER A 392
LYS A 395
SER A 448
ASN A 450
LYS A 618
GLY A 620
 None
 0.67A 1ghmA-3vskA:
15.7		 1ghmA-3vskA:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4q BETA-LACTAMASE

(Burkholderia
multivorans) 		PF13354
(Beta-lactamase2) 		7 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 220
 None
 1.01A 1ghmA-3w4qA:
38.2		 1ghmA-3w4qA:
32.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdj ENCA BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		7 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 SO4  A1291 (-3.4A)
None
SO4  A1291 (-3.1A)
None
SO4  A1291 (-3.3A)
SO4  A1291 (-3.3A)
SO4  A1291 ( 3.6A)
 0.31A 1ghmA-3zdjA:
35.5		 1ghmA-3zdjA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		6 SER B 394
LYS B 397
SER B 449
ASN B 451
LYS B 575
GLY B 577
 AIX  B 800 (-0.2A)
AIX  B 800 ( 3.1A)
AIX  B 800 (-2.4A)
AIX  B 800 (-2.7A)
AIX  B 800 ( 4.0A)
AIX  B 800 ( 3.7A)
 0.49A 1ghmA-3zg8B:
15.4		 1ghmA-3zg8B:
18.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
 0.24A 1ghmA-3znyA:
38.7		 1ghmA-3znyA:
32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		8 ALA A  48
SER A  49
LYS A  52
TYR A 147
SER A 298
ASN A 300
LYS A 410
GLY A 412
 B07  A 500 (-3.8A)
B07  A 500 (-1.4A)
B07  A 500 (-3.4A)
B07  A 500 (-4.1A)
B07  A 500 (-1.4A)
B07  A 500 ( 4.2A)
B07  A 500 (-1.6A)
B07  A 500 (-3.2A)
 1.00A 1ghmA-3zvtA:
7.1		 1ghmA-3zvtA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 PEG  A 307 (-2.4A)
PEG  A 307 ( 3.6A)
PEG  A 307 (-2.4A)
PEG  A 307 (-3.1A)
PEG  A 307 ( 3.4A)
PEG  A 307 (-2.7A)
 0.31A 1ghmA-4c6yA:
37.1		 1ghmA-4c6yA:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c75 BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		7 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 NA  A 294 ( 2.5A)
SO4  A 291 ( 4.6A)
SO4  A 291 (-2.8A)
None
SO4  A 291 (-3.4A)
NA  A 294 ( 3.2A)
SO4  A 291 (-4.1A)
 0.37A 1ghmA-4c75A:
37.2		 1ghmA-4c75A:
41.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2o PER-2 BETA-LACTAMASE

(Citrobacter
freundii) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
 0.49A 1ghmA-4d2oA:
29.8		 1ghmA-4d2oA:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
 0.37A 1ghmA-4ev4A:
37.5		 1ghmA-4ev4A:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewf BETA-LACTAMASE

(Sphaerobacter
thermophilus) 		PF13354
(Beta-lactamase2) 		7 ALA A  48
SER A  49
LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.35A 1ghmA-4ewfA:
28.9		 1ghmA-4ewfA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		7 SER A 294
LYS A 297
SER A 349
ASN A 351
LYS A 484
SER A 485
GLY A 486
 0W0  A 601 (-1.4A)
0W0  A 601 ( 4.2A)
0W0  A 601 (-3.1A)
0W0  A 601 (-3.1A)
0W0  A 601 (-3.0A)
0W0  A 601 (-2.9A)
0W0  A 601 (-3.4A)
 0.50A 1ghmA-4fsfA:
16.3		 1ghmA-4fsfA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		7 ALA A  55
SER A  56
LYS A  59
SER A 117
ASN A 119
LYS A 217
GLY A 219
 None
GOL  A 301 (-3.0A)
GOL  A 301 ( 4.2A)
GOL  A 301 (-2.7A)
None
GOL  A 301 ( 4.6A)
GOL  A 301 (-3.5A)
 0.35A 1ghmA-4hesA:
26.3		 1ghmA-4hesA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ied CLASS D
BETA-LACTAMASE

(Fusobacterium
nucleatum) 		PF00905
(Transpeptidase) 		6 ALA A  56
SER A  57
SER A 106
LYS A 196
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
 0.61A 1ghmA-4iedA:
18.2		 1ghmA-4iedA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0x BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		6 ALA A  78
SER A  79
SER A 126
LYS A 216
GLY A 218
ARG A 259
 None
KCX  A  82 (-2.5A)
BCT  A 301 (-2.8A)
BCT  A 301 (-3.0A)
BCT  A 301 (-3.4A)
BCT  A 301 (-3.0A)
 0.61A 1ghmA-4k0xA:
18.1		 1ghmA-4k0xA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		6 SER A 182
LYS A 185
SER A 237
ASN A 239
LYS A 397
GLY A 399
 None
 0.59A 1ghmA-4mnrA:
15.9		 1ghmA-4mnrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		6 SER A 286
LYS A 289
ASN A 335
LYS A 481
SER A 482
GLY A 483
 ONL  A 601 (-1.4A)
ONL  A 601 ( 4.0A)
ONL  A 601 (-3.5A)
ONL  A 601 ( 4.8A)
None
ONL  A 601 (-3.5A)
 0.57A 1ghmA-4o7dA:
4.9		 1ghmA-4o7dA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		7 ALA A  82
SER A  83
SER A 130
LYS A 220
SER A 221
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.1A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.50A 1ghmA-4oh0A:
17.1		 1ghmA-4oh0A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		7 ALA A 120
SER A 121
LYS A 124
SER A 176
ASN A 178
LYS A 282
GLY A 284
 MER  A 400 (-3.5A)
MER  A 400 (-1.3A)
MER  A 400 ( 4.1A)
MER  A 400 (-2.5A)
MER  A 400 (-3.0A)
MER  A 400 (-3.0A)
MER  A 400 (-3.1A)
 0.38A 1ghmA-4pprA:
19.6		 1ghmA-4pprA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		6 SER A 682
LYS A 685
SER A 737
ASN A 739
LYS A 890
GLY A 892
 NXU  A1001 (-1.3A)
NXU  A1001 ( 4.2A)
NXU  A1001 (-3.2A)
NXU  A1001 (-3.5A)
NXU  A1001 (-3.5A)
NXU  A1001 (-3.4A)
 0.40A 1ghmA-4ra7A:
15.3		 1ghmA-4ra7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		6 SER A 682
LYS A 685
TYR A 720
SER A 737
LYS A 890
GLY A 892
 NXU  A1001 (-1.3A)
NXU  A1001 ( 4.2A)
NXU  A1001 (-4.1A)
NXU  A1001 (-3.2A)
NXU  A1001 (-3.5A)
NXU  A1001 (-3.4A)
 0.87A 1ghmA-4ra7A:
15.3		 1ghmA-4ra7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		7 ALA A  68
SER A  69
LYS A  72
SER A 124
ASN A 126
LYS A 230
GLY A 232
 None
 0.27A 1ghmA-4ryeA:
20.9		 1ghmA-4ryeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		7 SER A 321
LYS A 324
SER A 376
ASN A 378
LYS A 520
SER A 521
GLY A 522
 None
 0.93A 1ghmA-4ye5A:
15.8		 1ghmA-4ye5A:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		6 SER A  71
LYS A  74
SER A 131
ASN A 133
LYS A 233
GLY A 235
 ACT  A 301 (-3.5A)
ACT  A 301 ( 4.8A)
ACT  A 301 (-2.9A)
None
ACT  A 301 (-3.4A)
ACT  A 301 (-3.3A)
 0.28A 1ghmA-4yfmA:
36.3		 1ghmA-4yfmA:
32.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		6 SER A 400
LYS A 403
SER A 454
ASN A 456
LYS A 568
GLY A 570
 NHE  A 901 (-3.2A)
None
NHE  A 901 (-2.9A)
None
NHE  A 901 (-3.0A)
NHE  A 901 (-3.6A)
 0.50A 1ghmA-4ztkA:
15.8		 1ghmA-4ztkA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		9 SER A 200
LYS A 203
TYR A 235
SER A 260
ASN A 262
LYS A 364
SER A 365
GLY A 366
ARG A 373
 None
 0.57A 1ghmA-5aqaA:
34.2		 1ghmA-5aqaA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5boh BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		7 ALA A  82
SER A  83
SER A 130
LYS A 220
SER A 221
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.7A)
KCX  A  86 ( 3.5A)
KCX  A  86 ( 4.5A)
None
None
None
 0.61A 1ghmA-5bohA:
17.0		 1ghmA-5bohA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		6 ALA A  57
LYS A  61
SER A 239
ASN A 241
LYS A 345
GLY A 347
 None
 0.25A 1ghmA-5cerA:
18.5		 1ghmA-5cerA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		6 SER A 345
LYS A 348
SER A 398
ASN A 400
LYS A 539
GLY A 541
 35P  A 702 (-1.3A)
35P  A 702 ( 4.2A)
35P  A 702 (-2.9A)
35P  A 702 (-3.1A)
35P  A 702 (-3.3A)
35P  A 702 (-3.5A)
 0.48A 1ghmA-5cxwA:
16.5		 1ghmA-5cxwA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		6 SER A 291
LYS A 294
ASN A 340
LYS A 486
SER A 487
GLY A 488
 None
 0.42A 1ghmA-5d3oA:
4.9		 1ghmA-5d3oA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		6 SER A  47
LYS A  50
SER A 107
ASN A 109
LYS A 211
GLY A 213
 None
 0.32A 1ghmA-5e2eA:
38.9		 1ghmA-5e2eA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 131
ASN A 133
LYS A 235
GLY A 237
 ACT  A 311 (-3.2A)
None
ACT  A 311 (-3.0A)
None
ACT  A 311 (-3.3A)
ACT  A 311 (-3.2A)
 0.20A 1ghmA-5e43A:
38.9		 1ghmA-5e43A:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		6 SER A  62
LYS A  65
SER A 123
ASN A 125
LYS A 227
GLY A 229
 CIT  A 303 (-2.8A)
CIT  A 303 (-3.6A)
CIT  A 303 (-2.5A)
CIT  A 303 (-3.2A)
CIT  A 303 (-3.5A)
CIT  A 303 (-3.5A)
 0.26A 1ghmA-5eoeA:
36.3		 1ghmA-5eoeA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		7 SER A  64
LYS A  67
SER A 125
ASN A 127
LYS A 229
GLY A 231
ARG A 238
 IM2  A 301 (-1.4A)
IM2  A 301 ( 3.9A)
IM2  A 301 (-2.7A)
IM2  A 301 (-3.2A)
IM2  A 301 (-3.3A)
IM2  A 301 (-3.3A)
IM2  A 301 (-3.5A)
 0.29A 1ghmA-5f83A:
35.6		 1ghmA-5f83A:
28.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gl9 BETA-LACTAMASE

(Burkholderia
thailandensis) 		PF13354
(Beta-lactamase2) 		6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 None
 0.24A 1ghmA-5gl9A:
38.4		 1ghmA-5gl9A:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		6 SER A 510
LYS A 513
SER A 572
ASN A 574
LYS A 698
GLY A 700
 AZR  A 902 (-1.4A)
AZR  A 902 ( 4.0A)
AZR  A 902 ( 3.7A)
AZR  A 902 (-3.4A)
AZR  A 902 ( 4.5A)
AZR  A 902 (-3.3A)
 0.38A 1ghmA-5hlbA:
16.6		 1ghmA-5hlbA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy2 BETA-LACTAMASE
OXA-143

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		7 ALA A  80
SER A  81
SER A 128
LYS A 218
SER A 219
GLY A 220
ARG A 261
 None
KCX  A  84 (-2.7A)
GOL  A 301 (-3.6A)
GOL  A 301 ( 4.7A)
GOL  A 301 (-2.8A)
GOL  A 301 (-3.3A)
GOL  A 301 (-3.1A)
 0.75A 1ghmA-5iy2A:
18.3		 1ghmA-5iy2A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzh BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		7 ALA A  79
SER A  80
SER A 127
LYS A 217
SER A 218
GLY A 219
ARG A 260
 FMT  A 301 (-3.2A)
FMT  A 301 (-2.5A)
FMT  A 301 (-3.3A)
KCX  A  83 ( 4.9A)
None
FMT  A 301 (-3.3A)
None
 0.67A 1ghmA-5kzhA:
18.3		 1ghmA-5kzhA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 6YV  A 301 (-1.7A)
6YV  A 301 ( 3.8A)
6YV  A 301 (-2.6A)
6YV  A 301 (-3.7A)
6YV  A 301 (-3.6A)
6YV  A 301 ( 4.0A)
 0.44A 1ghmA-5ll7A:
37.7		 1ghmA-5ll7A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfq BETA-LACTAMASE

(Bacteroides
cellulosilyticus) 		PF13354
(Beta-lactamase2) 		6 SER A  48
LYS A  51
SER A 112
ASN A 114
LYS A 215
GLY A 217
 PO4  A 301 (-3.8A)
None
PO4  A 301 (-2.6A)
None
PO4  A 301 (-3.2A)
PO4  A 301 (-3.3A)
 0.20A 1ghmA-5tfqA:
30.6		 1ghmA-5tfqA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		7 ALA A  65
SER A  66
LYS A  69
SER A 129
ASN A 131
LYS A 232
GLY A 234
 None
 0.59A 1ghmA-5tr7A:
21.6		 1ghmA-5tr7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		6 SER A 314
LYS A 317
SER A 368
ASN A 370
LYS A 513
GLY A 515
 None
 0.40A 1ghmA-5troA:
16.5		 1ghmA-5troA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 7 ALA A  74
SER A  75
LYS A  78
SER A 139
ASN A 141
LYS A 259
GLY A 261
 NFF  A 401 ( 3.7A)
NFF  A 401 (-1.1A)
NFF  A 401 ( 4.4A)
NFF  A 401 (-3.4A)
None
NFF  A 401 ( 4.8A)
NFF  A 401 (-3.7A)
 0.58A 1ghmA-5ty7A:
20.6		 1ghmA-5ty7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		7 SER A 343
LYS A 346
SER A 402
ASN A 404
LYS A 553
SER A 554
GLY A 555
 None
 0.43A 1ghmA-5u47A:
16.7		 1ghmA-5u47A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		6 SER A 306
LYS A 309
SER A 360
ASN A 362
LYS A 497
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
None
SO4  A 701 (-3.4A)
 0.71A 1ghmA-5uy7A:
16.3		 1ghmA-5uy7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Burkholderia
ambifaria) 		PF00905
(Transpeptidase) 		6 SER A 306
LYS A 309
SER A 360
ASN A 362
SER A 498
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
SO4  A 701 (-2.6A)
SO4  A 701 (-3.4A)
 0.83A 1ghmA-5uy7A:
16.3		 1ghmA-5uy7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfd BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		7 ALA A  80
SER A  81
SER A 128
LYS A 218
SER A 219
GLY A 220
ARG A 261
 9CP  A 306 (-3.3A)
9CP  A 306 (-1.4A)
9CP  A 306 (-2.8A)
9CP  A 306 (-3.0A)
9CP  A 306 (-2.9A)
9CP  A 306 (-3.5A)
9CP  A 306 (-2.7A)
 0.63A 1ghmA-5vfdA:
17.8		 1ghmA-5vfdA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5g BETA-LACTAMASE

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		6 SER A  56
LYS A  59
SER A 120
ASN A 122
LYS A 224
GLY A 226
 OP0  A 305 (-1.5A)
OP0  A 305 (-3.6A)
OP0  A 305 (-2.7A)
OP0  A 305 (-3.1A)
OP0  A 305 (-3.4A)
OP0  A 305 (-3.2A)
 0.29A 1ghmA-5x5gA:
31.6		 1ghmA-5x5gA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 7 ALA A  57
SER A  58
LYS A  61
SER A 118
ASN A 120
LYS A 222
GLY A 224
 CES  A 301 (-3.5A)
CES  A 301 (-1.3A)
CES  A 301 ( 4.1A)
CES  A 301 ( 3.7A)
CES  A 301 (-3.3A)
None
CES  A 301 (-3.2A)
 0.37A 1ghmA-5zqeA:
21.4		 1ghmA-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 7 SER A  58
LYS A  61
SER A 118
ASN A 120
LYS A 222
GLY A 224
ARG A 257
 CES  A 301 (-1.3A)
CES  A 301 ( 4.1A)
CES  A 301 ( 3.7A)
CES  A 301 (-3.3A)
None
CES  A 301 (-3.2A)
CES  A 301 (-2.9A)
 0.79A 1ghmA-5zqeA:
21.4		 1ghmA-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azi D-ALANYL-D-ALANINE
ENDOPEPTIDASE

(Enterobacter
cloacae) 		PF00768
(Peptidase_S11) 		6 ALA A  67
LYS A  71
SER A 125
ASN A 127
LYS A 232
GLY A 234
 SEE  A  68 ( 2.7A)
SEE  A  68 ( 2.8A)
SEE  A  68 ( 1.4A)
SEE  A  68 ( 3.6A)
SEE  A  68 ( 3.5A)
SEE  A  68 ( 3.9A)
 0.40A 1ghmA-6aziA:
20.8		 1ghmA-6aziA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 6 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
 3GK  A 301 ( 3.8A)
3GK  A 301 ( 4.0A)
3GK  A 301 (-2.7A)
3GK  A 301 (-3.5A)
3GK  A 301 ( 4.1A)
3GK  A 301 (-3.4A)
 0.34A 1ghmA-6bu3A:
38.6		 1ghmA-6bu3A:
15.35