SIMILAR PATTERNS OF AMINO ACIDS FOR 1GAH_A_ACRA497

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		5 TRP A 341
ARG A 343
ASP A 344
GLY A 392
GLU A 438
 ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
None
ACR  A 700 (-3.5A)
 0.72A 1gahA-1lf9A:
29.6		 1gahA-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		9 TYR A 337
TRP A 341
ARG A 343
ASP A 344
GLU A 438
GLU A 439
TYR A 581
TRP A 599
GLU A 636
 ACR  A 700 (-4.3A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.6A)
ACR  A 700 (-3.0A)
ACR  A 700 (-3.5A)
ACR  A 700 (-3.7A)
ACR  A 700 (-3.7A)
None
None
 0.31A 1gahA-1lf9A:
29.6		 1gahA-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 TRP A 330
ARG A 332
ASP A 333
GLY A 382
GLU A 430
 ACR  A3000 (-3.7A)
ACR  A3000 (-3.7A)
ACR  A3000 (-3.1A)
None
ACR  A3000 (-3.6A)
 0.83A 1gahA-1ulvA:
31.6		 1gahA-1ulvA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		9 TYR A 326
TRP A 330
ARG A 332
ASP A 333
GLU A 430
GLU A 431
TYR A 573
TRP A 591
GLU A 628
 ACR  A3000 (-3.9A)
ACR  A3000 (-3.7A)
ACR  A3000 (-3.7A)
ACR  A3000 (-3.1A)
ACR  A3000 (-3.6A)
ACR  A3000 (-3.5A)
ACR  A3000 (-3.7A)
None
None
 0.36A 1gahA-1ulvA:
31.6		 1gahA-1ulvA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		11 TYR A  63
TRP A  67
ARG A  69
ASP A  70
TRP A 139
GLY A 140
GLU A 210
GLU A 211
TYR A 351
TRP A 362
GLU A 456
 ACR  A 995 (-4.3A)
ACR  A 995 (-3.4A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.0A)
ACR  A 995 (-3.5A)
ACR  A 995 (-3.3A)
ACR  A 995 (-3.7A)
ACR  A 995 (-3.5A)
ACR  A 995 ( 3.7A)
None
ACR  A 995 ( 4.6A)
 0.15A 1gahA-2f6dA:
45.7		 1gahA-2f6dA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		11 TYR A  47
TRP A  51
ARG A  53
ASP A  54
TRP A 120
GLY A 121
GLU A 179
GLU A 180
TYR A 315
TRP A 321
GLU A 404
 BTB  A 620 (-3.9A)
BTB  A 620 (-3.8A)
BTB  A 620 (-3.7A)
BTB  A 620 (-2.8A)
None
None
BTB  A 620 (-3.6A)
None
BTB  A 620 ( 4.9A)
None
BTB  A 620 (-4.0A)
 0.29A 1gahA-2vn7A:
62.4		 1gahA-2vn7A:
47.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE

(Xanthomonas
campestris) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 TYR A 115
TRP A 525
GLY A 104
TYR A  95
GLU A 496
 None
 1.30A 1gahA-2wpgA:
undetectable		 1gahA-2wpgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 ASP A 140
TRP A 246
GLY A 245
GLU A 244
GLU A 243
 None
 1.18A 1gahA-2zciA:
undetectable		 1gahA-2zciA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		5 TYR A 114
TRP A 524
GLY A 103
TYR A  94
GLU A 495
 None
 1.31A 1gahA-3czeA:
undetectable		 1gahA-3czeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 TYR A 125
ARG A 538
ASP A 535
GLY A 120
GLU A 113
 None
 1.29A 1gahA-3dkhA:
undetectable		 1gahA-3dkhA:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		12 TYR A  72
TRP A  76
ARG A  78
ASP A  79
TRP A 144
GLY A 145
TYR A 199
GLU A 203
GLU A 204
TYR A 335
TRP A 341
GLU A 424
 TRS  A 701 (-4.5A)
TRS  A 701 (-3.8A)
TRS  A 701 (-3.8A)
TRS  A 701 (-2.8A)
None
None
None
TRS  A 701 ( 3.8A)
GOL  A 801 (-3.6A)
GOL  A 801 ( 4.1A)
None
None
 0.24A 1gahA-3eqaA:
69.8		 1gahA-3eqaA:
95.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on6 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		5 TRP A 107
ARG A 109
ASP A 110
TRP A 403
GLU A 439
 EDO  A 492 (-3.3A)
None
EDO  A 492 (-3.0A)
None
None
 0.74A 1gahA-3on6A:
23.9		 1gahA-3on6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 TYR A 299
ASP A 526
GLY A 443
TYR A 469
GLU A 442
 MTT  A 802 (-4.0A)
MTT  A 802 (-2.9A)
None
None
MTT  A 802 (-3.0A)
 1.33A 1gahA-3wdjA:
undetectable		 1gahA-3wdjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 5 TYR B 191
ARG B 120
ASP B 160
TYR B 129
GLU B 152
 None
ACT  B 302 (-4.0A)
ZN  B 301 (-2.5A)
None
None
 1.27A 1gahA-4nt9B:
undetectable		 1gahA-4nt9B:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 TRP A 260
GLY A 259
GLU A 258
GLU A 257
GLU A 188
 None
 1.38A 1gahA-4ox2A:
undetectable		 1gahA-4ox2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		5 TYR A  28
TRP A  32
ASP A  35
TRP A 355
GLU A 393
 TRS  A 501 (-3.7A)
TRS  A 501 (-4.5A)
TRS  A 501 (-3.0A)
None
TRS  A 501 (-3.7A)
 1.10A 1gahA-4wvaA:
20.2		 1gahA-4wvaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		5 TYR A  28
TRP A  32
TYR A 349
TRP A 355
GLU A 393
 TRS  A 501 (-3.7A)
TRS  A 501 (-4.5A)
TRS  A 501 (-4.3A)
None
TRS  A 501 (-3.7A)
 1.13A 1gahA-4wvaA:
20.2		 1gahA-4wvaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apm VP0

(Parechovirus A) 		PF00073
(Rhv) 		5 ASP C 194
GLY C 241
TYR C 187
GLU C 188
TYR C 246
 None
 1.47A 1gahA-5apmC:
undetectable		 1gahA-5apmC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		5 TYR A  47
ASP A  54
GLY A 183
TYR A 370
GLU A 414
 FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
None
FRU  A 501 (-4.8A)
GOL  A 502 ( 4.9A)
 1.29A 1gahA-5gooA:
22.1		 1gahA-5gooA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ARG A 118
ASP A 122
TYR A 109
GLU A 110
TRP A 376
 None
 1.50A 1gahA-5mdnA:
undetectable		 1gahA-5mdnA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 5 TYR B 746
GLY B 976
TYR B 690
GLU B 960
TYR B1023
 None
 1.05A 1gahA-6f42B:
undetectable		 1gahA-6f42B:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 11 TYR A  75
TRP A  79
ARG A  81
ASP A  82
TRP A 154
GLY A 155
GLU A 213
GLU A 214
TYR A 347
TRP A 353
GLU A 436
 B3P  A 652 (-4.1A)
B3P  A 652 ( 4.1A)
B3P  A 652 (-4.0A)
B3P  A 652 (-2.8A)
B3P  A 652 (-4.3A)
None
B3P  A 652 (-3.7A)
B3P  A 652 (-3.4A)
B3P  A 652 ( 3.8A)
None
B3P  A 652 ( 4.6A)
 0.31A 1gahA-6fhvA:
62.7		 1gahA-6fhvA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 11 TYR A  76
TRP A  80
ARG A  82
ASP A  83
TRP A 149
GLY A 150
GLU A 208
GLU A 209
TYR A 341
TRP A 347
GLU A 432
 ACR  A 801 (-4.3A)
ACR  A 801 (-3.3A)
ACR  A 801 (-4.0A)
ACR  A 801 (-2.7A)
ACR  A 801 (-3.7A)
ACR  A 801 (-3.1A)
ACR  A 801 (-3.9A)
ACR  A 801 (-3.9A)
ACR  A 801 ( 3.9A)
None
ACR  A 801 (-4.4A)
 0.29A 1gahA-6fhwA:
60.5		 1gahA-6fhwA:
10.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 12 TYR A  72
TRP A  76
ARG A  78
ASP A  79
TRP A 144
GLY A 145
TYR A 199
GLU A 203
GLU A 204
TYR A 335
TRP A 341
GLU A 424
 None
 0.25A 1gahA-6frvA:
68.4		 1gahA-6frvA:
83.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1col COLICIN A

(Escherichia
coli) 		PF01024
(Colicin) 		4 ALA A 162
SER A 102
LEU A 179
TRP A  86
 None
 1.11A 1gahA-1colA:
undetectable		 1gahA-1colA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 299
SER A 353
LEU A 300
TRP A 305
 None
 0.84A 1gahA-1dm3A:
undetectable		 1gahA-1dm3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ALA A 295
TRP A 411
ARG A 354
LEU A 292
 None
 1.07A 1gahA-1e43A:
undetectable		 1gahA-1e43A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		4 ALA A 371
SER A 338
ARG A 397
LEU A 359
 None
 1.12A 1gahA-1ei5A:
undetectable		 1gahA-1ei5A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g01 ENDOGLUCANASE

(Bacillus sp.
KSM-635) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 ALA A 530
SER A 447
ARG A 292
LEU A 521
 None
 1.21A 1gahA-1g01A:
undetectable		 1gahA-1g01A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ALA A 139
SER A 282
ARG A  63
LEU A 129
 None
 1.07A 1gahA-1jkwA:
undetectable		 1gahA-1jkwA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 ALA A 514
ARG A 584
LEU A 515
TRP A 609
 None
 1.16A 1gahA-1kehA:
undetectable		 1gahA-1kehA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		5 ALA A 319
TRP A 437
ARG A 575
LEU A 652
TRP A 654
 ACR  A 700 (-3.2A)
ACR  A 700 (-4.8A)
ACR  A 700 (-3.0A)
None
None
 0.41A 1gahA-1lf9A:
29.6		 1gahA-1lf9A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		4 ALA A 104
SER A  91
ARG A 167
LEU A 139
 None
 1.08A 1gahA-1luaA:
undetectable		 1gahA-1luaA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		4 ALA A  95
SER A  79
ARG B  18
LEU A  92
 None
 1.17A 1gahA-1mhmA:
undetectable		 1gahA-1mhmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ng0 COAT PROTEIN

(Cocksfoot
mottle virus) 		PF00729
(Viral_coat) 		4 ALA A  94
SER A  85
TRP A 236
LEU A  95
 ALA  A  94 ( 0.0A)
SER  A  85 ( 0.0A)
TRP  A 236 ( 0.5A)
LEU  A  95 ( 0.6A)
 1.18A 1gahA-1ng0A:
undetectable		 1gahA-1ng0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ALA A 273
SER A 223
TRP A 188
LEU A 274
 None
SO4  A 307 (-2.6A)
None
None
 1.02A 1gahA-1qgzA:
undetectable		 1gahA-1qgzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ALA A  96
SER A 390
LEU A 100
TRP A 103
 None
 1.02A 1gahA-1qlbA:
undetectable		 1gahA-1qlbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 ALA A 299
SER A 620
ARG A 741
LEU A 672
 None
 1.16A 1gahA-1uf2A:
undetectable		 1gahA-1uf2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		5 ALA A 307
TRP A 429
ARG A 567
LEU A 653
TRP A 655
 ACR  A3000 (-3.4A)
ACR  A3000 (-4.9A)
ACR  A3000 (-2.9A)
None
None
 0.51A 1gahA-1ulvA:
31.6		 1gahA-1ulvA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ALA A 300
TRP A 413
ARG A 359
LEU A 297
 None
 1.18A 1gahA-1w9xA:
undetectable		 1gahA-1w9xA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		4 ALA A 222
SER A 185
TRP A 253
TRP A  32
 None
 1.19A 1gahA-1xe4A:
undetectable		 1gahA-1xe4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HEAT SHOCK 70 KDA
PROTEIN 1

(Homo sapiens) 		PF00012
(HSP70) 		4 ALA C 270
SER C 254
ARG C 301
LEU C 274
 None
 0.98A 1gahA-1xqsC:
undetectable		 1gahA-1xqsC:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		4 ALA C 345
ARG C 415
LEU C 346
TRP C 440
 None
 1.18A 1gahA-2advC:
undetectable		 1gahA-2advC:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A 423
SER A 330
TRP A 342
LEU A 153
 None
 1.14A 1gahA-2bccA:
undetectable		 1gahA-2bccA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ALA A 300
TRP A 413
ARG A 359
LEU A 297
 None
 1.06A 1gahA-2d3lA:
undetectable		 1gahA-2d3lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ALA A 300
TRP A 413
ARG A 359
LEU A 297
 None
 1.14A 1gahA-2dieA:
undetectable		 1gahA-2dieA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 202
SER A 168
ARG A 222
LEU A 226
 None
None
NAD  A1403 (-3.0A)
None
 1.20A 1gahA-2dphA:
undetectable		 1gahA-2dphA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 ALA A 343
SER A 184
ARG A 282
LEU A 305
 None
 1.07A 1gahA-2dpyA:
undetectable		 1gahA-2dpyA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		5 ALA A  54
TRP A 209
ARG A 345
LEU A 471
TRP A 473
 ACR  A 995 (-3.4A)
None
ACR  A 995 (-3.0A)
None
None
 0.18A 1gahA-2f6dA:
45.7		 1gahA-2f6dA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fek LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		4 ALA A  19
SER A  69
LEU A  23
TRP A 138
 None
 1.13A 1gahA-2fekA:
undetectable		 1gahA-2fekA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ALA A 303
SER A 423
TRP A 248
LEU A 300
 None
 1.19A 1gahA-2iu3A:
undetectable		 1gahA-2iu3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 ALA A 297
SER A 345
LEU A 351
TRP A 229
 None
 1.05A 1gahA-2j3zA:
undetectable		 1gahA-2j3zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksn UBIQUITIN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF16455
(UBD) 		4 ALA A 104
SER A  41
ARG A 115
LEU A 100
 None
 1.17A 1gahA-2ksnA:
undetectable		 1gahA-2ksnA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		4 ALA A  30
TRP A 136
ARG A 138
LEU A  27
 None
 1.16A 1gahA-2p68A:
undetectable		 1gahA-2p68A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 ALA A 449
TRP A 381
LEU A 452
TRP A 414
 None
 1.16A 1gahA-2pq6A:
undetectable		 1gahA-2pq6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 ALA A 358
TRP A 538
ARG A 350
LEU A 363
 MN  A 765 ( 4.8A)
None
None
None
 1.21A 1gahA-2qvwA:
undetectable		 1gahA-2qvwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		4 ALA A 270
SER A 254
ARG A 301
LEU A 274
 None
 0.92A 1gahA-2v7zA:
undetectable		 1gahA-2v7zA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 ALA A  38
TRP A 178
ARG A 309
LEU A 419
TRP A 421
 BTB  A 620 ( 3.8A)
None
BTB  A 620 (-3.6A)
None
None
 0.38A 1gahA-2vn7A:
62.4		 1gahA-2vn7A:
47.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzk GLUTAMATE
N-ACETYLTRANSFERASE
2 BETA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 ALA B 248
SER B 219
ARG B 202
LEU B 244
 None
 1.11A 1gahA-2vzkB:
undetectable		 1gahA-2vzkB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ALA A 407
SER A 229
TRP A 319
LEU A 207
 None
 1.11A 1gahA-2zr2A:
undetectable		 1gahA-2zr2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		4 ALA A 411
SER A  53
ARG A 330
LEU A 412
 None
 1.18A 1gahA-2zukA:
undetectable		 1gahA-2zukA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		no annotation 4 ALA C 168
SER C 110
ARG C 125
LEU C 172
 None
 0.84A 1gahA-3a28C:
undetectable		 1gahA-3a28C:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		4 ALA A 290
SER A 439
ARG A 253
LEU A 296
 None
 0.99A 1gahA-3alxA:
undetectable		 1gahA-3alxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza sativa) 		PF07859
(Abhydrolase_3) 		4 ALA A 269
SER A 195
ARG A 251
LEU A 259
 None
None
GA4  A 401 (-3.8A)
None
 1.23A 1gahA-3eblA:
undetectable		 1gahA-3eblA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		4 ALA A1786
ARG A1754
LEU A1783
TRP A1787
 None
 1.13A 1gahA-3edvA:
undetectable		 1gahA-3edvA:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eqa GLUCOAMYLASE

(Aspergillus
niger) 		PF00723
(Glyco_hydro_15) 		6 ALA A  63
SER A 143
TRP A 202
ARG A 329
LEU A 439
TRP A 441
 TRS  A 701 ( 3.8A)
None
None
GOL  A 801 (-3.3A)
None
None
 0.22A 1gahA-3eqaA:
69.8		 1gahA-3eqaA:
95.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ALA A 423
SER A 330
TRP A 342
LEU A 153
 None
 1.05A 1gahA-3h1lA:
undetectable		 1gahA-3h1lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		4 ALA A  16
SER A 310
ARG A 334
LEU A  20
 None
 1.10A 1gahA-3h8lA:
undetectable		 1gahA-3h8lA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 ALA B 168
TRP B 143
ARG B  92
LEU B  79
 None
 1.12A 1gahA-3lcvB:
undetectable		 1gahA-3lcvB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 ALA A 150
SER A 174
ARG A  15
LEU A 154
 None
 1.22A 1gahA-3my7A:
undetectable		 1gahA-3my7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3og9 PROTEIN YAHD A
COPPER INDUCIBLE
HYDROLASE

(Lactococcus
lactis) 		PF01738
(DLH) 		4 ALA A 110
SER A 185
TRP A 201
LEU A 114
 None
 1.12A 1gahA-3og9A:
undetectable		 1gahA-3og9A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		4 ALA A 194
SER A   7
TRP A  19
LEU A 128
 None
 1.23A 1gahA-3p8rA:
undetectable		 1gahA-3p8rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 ALA A 434
TRP A 145
ARG A 405
LEU A 363
 None
 1.14A 1gahA-3rdeA:
undetectable		 1gahA-3rdeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rft URONATE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 ALA A 159
SER A 181
ARG A 194
LEU A 198
 None
 1.16A 1gahA-3rftA:
undetectable		 1gahA-3rftA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9v ABIETADIENE
SYNTHASE,
CHLOROPLASTIC

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ALA A 245
SER A 288
TRP A 176
LEU A 252
 None
 1.18A 1gahA-3s9vA:
5.0		 1gahA-3s9vA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 ALA A 377
SER A 215
TRP A 414
ARG A 392
 None
 1.17A 1gahA-3t05A:
undetectable		 1gahA-3t05A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ALA A 120
TRP A 106
LEU A 380
TRP A  81
 None
 1.20A 1gahA-3uszA:
undetectable		 1gahA-3uszA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ALA A  25
TRP A 132
ARG A 134
LEU A  22
 None
 1.22A 1gahA-3v2hA:
undetectable		 1gahA-3v2hA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 ALA A  55
SER A  15
ARG A  35
LEU A  71
 None
 1.13A 1gahA-3vscA:
undetectable		 1gahA-3vscA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ALA A 401
SER A 363
TRP A 448
LEU A 399
 None
 0.99A 1gahA-3w5nA:
18.9		 1gahA-3w5nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 ALA A  90
TRP A 273
LEU A 342
TRP A 346
 None
 1.17A 1gahA-3w9vA:
undetectable		 1gahA-3w9vA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wge THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 ALA A 231
SER A 195
TRP A 267
LEU A 234
 None
 1.18A 1gahA-3wgeA:
undetectable		 1gahA-3wgeA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 ALA A 159
SER A 188
TRP A 203
LEU A 180
 None
 1.23A 1gahA-3whiA:
undetectable		 1gahA-3whiA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		4 ALA A 314
SER A 302
TRP A 213
LEU A 196
 None
 1.23A 1gahA-3zokA:
undetectable		 1gahA-3zokA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 ALA A  44
SER A  82
ARG A 116
LEU A  36
 None
 1.10A 1gahA-4au2A:
undetectable		 1gahA-4au2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 ALA A 156
SER A  70
ARG A  49
LEU A 214
 None
 1.11A 1gahA-4azvA:
undetectable		 1gahA-4azvA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 ALA A 156
SER A  70
ARG A  49
LEU A 214
 None
 1.10A 1gahA-4azwA:
undetectable		 1gahA-4azwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ALA A 105
SER A 113
ARG A  85
LEU A 208
 None
 1.15A 1gahA-4bedA:
undetectable		 1gahA-4bedA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bos UBIQUITIN
THIOESTERASE OTU1

(Homo sapiens) 		PF02338
(OTU) 		4 ALA A 297
SER A 229
ARG A 245
LEU A 298
 None
 1.11A 1gahA-4bosA:
undetectable		 1gahA-4bosA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ALA A 114
TRP A 493
ARG A 487
TRP A 478
 None
 1.12A 1gahA-4c7gA:
undetectable		 1gahA-4c7gA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 ALA A 695
SER A 488
ARG A 634
LEU A 697
 None
 1.20A 1gahA-4ipeA:
undetectable		 1gahA-4ipeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqh DYSFERLIN

(Homo sapiens) 		PF00168
(C2) 		4 ALA A  86
SER A 124
TRP A  48
LEU A 107
 None
 1.11A 1gahA-4iqhA:
undetectable		 1gahA-4iqhA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k00 1,4-DIHYDROXY-2-NAPH
THOYL-COA HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF03061
(4HBT) 		4 SER A  62
TRP A  37
LEU A 124
TRP A 128
 None
 1.15A 1gahA-4k00A:
undetectable		 1gahA-4k00A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG

(Schizosaccharomyces
pombe) 		PF04388
(Hamartin) 		4 ALA A  74
SER A  34
LEU A  71
TRP A  72
 None
 1.07A 1gahA-4kk1A:
undetectable		 1gahA-4kk1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 4 ALA A 335
SER A 386
TRP A 261
LEU A 283
 None
 1.22A 1gahA-4lypA:
undetectable		 1gahA-4lypA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 300
SER A 354
LEU A 301
TRP A 306
 None
 0.93A 1gahA-4o99A:
undetectable		 1gahA-4o99A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4of0 PROTEIN SYG-1,
ISOFORM B

(Caenorhabditis
elegans) 		PF07679
(I-set)
PF08205
(C2-set_2) 		4 ALA A 142
SER A 229
ARG A 236
LEU A 266
 None
 1.12A 1gahA-4of0A:
undetectable		 1gahA-4of0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ALA A 234
SER A 210
ARG A 117
LEU A 237
 None
None
None
HEM  A 501 ( 4.5A)
 1.18A 1gahA-4oqsA:
undetectable		 1gahA-4oqsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt ECDYSONE RECEPTOR
RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		4 ALA U 244
SER E 439
ARG U 326
LEU U 241
 None
 1.14A 1gahA-4oztU:
undetectable		 1gahA-4oztU:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qd9 THIOESTERASE PA1618

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 ALA A  31
SER A 128
TRP A 116
TRP A   4
 None
 1.20A 1gahA-4qd9A:
undetectable		 1gahA-4qd9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhx UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF11958
(DUF3472)
PF16871
(DUF5077) 		4 ALA A 414
TRP A 349
ARG A 343
LEU A 415
 None
SO4  A 502 (-4.3A)
SO4  A 502 (-3.8A)
None
 1.21A 1gahA-4qhxA:
undetectable		 1gahA-4qhxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ALA A 609
SER A 665
ARG A 336
LEU A 610
 None
 1.23A 1gahA-4qmeA:
undetectable		 1gahA-4qmeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 ALA A 452
SER A 414
TRP A 447
LEU A 519
 None
 1.13A 1gahA-4qq1A:
undetectable		 1gahA-4qq1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		4 ALA A 320
SER A 117
TRP A 312
LEU A 323
 None
 1.23A 1gahA-4r6yA:
undetectable		 1gahA-4r6yA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		4 ALA A 350
SER A 288
TRP A 271
LEU A 354
 None
 1.17A 1gahA-4u0tA:
undetectable		 1gahA-4u0tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 SER A 124
TRP A 546
ARG A 529
LEU A 566
 None
 1.12A 1gahA-4xqkA:
undetectable		 1gahA-4xqkA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		4 ALA A 304
TRP A 292
ARG A 260
LEU A 276
 None
 1.15A 1gahA-4xwuA:
undetectable		 1gahA-4xwuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR

(Streptomyces
coelicolor) 		PF00392
(GntR)
PF07702
(UTRA) 		4 ALA A 126
ARG A 139
LEU A 129
TRP A 233
 None
 1.15A 1gahA-4zs8A:
undetectable		 1gahA-4zs8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ALA A1561
TRP A1028
ARG A1033
LEU A1562
 None
 1.23A 1gahA-5a31A:
undetectable		 1gahA-5a31A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		4 ALA A 339
SER A 264
ARG A 114
LEU A 330
 None
 1.14A 1gahA-5fipA:
undetectable		 1gahA-5fipA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdq FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA H  12
SER H 172
ARG H  40
LEU H  82
 None
 1.17A 1gahA-5hdqH:
undetectable		 1gahA-5hdqH:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 ALA A  96
SER A 186
LEU A 339
TRP A 343
 None
 1.22A 1gahA-5j1dA:
undetectable		 1gahA-5j1dA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio;
Streptococcus
pyogenes) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 ALA A 695
SER A 488
ARG A 634
LEU A 697
 None
 1.22A 1gahA-5tthA:
undetectable		 1gahA-5tthA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ALA A2266
SER A  69
ARG A 183
LEU A  90
 None
None
MK6  A2402 (-4.0A)
None
 1.10A 1gahA-5tzyA:
undetectable		 1gahA-5tzyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C

(Paenibacillus
sp. A11-2) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 ALA A 186
SER A 212
TRP A 122
LEU A 228
 None
FMN  A 501 ( 3.3A)
None
None
 1.08A 1gahA-5xdeA:
undetectable		 1gahA-5xdeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 SER A 155
ARG A 256
LEU A 248
TRP A 250
 None
 1.12A 1gahA-5xnpA:
undetectable		 1gahA-5xnpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 SER A 627
TRP A 576
ARG A 572
LEU A 559
 None
 1.16A 1gahA-6b6lA:
undetectable		 1gahA-6b6lA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 4 ALA A 436
TRP A 364
LEU A 439
TRP A 397
 None
 1.23A 1gahA-6bk1A:
undetectable		 1gahA-6bk1A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 4 ALA A 318
SER A1126
ARG A 234
LEU A 326
 None
 1.10A 1gahA-6d35A:
undetectable		 1gahA-6d35A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 5 ALA A  66
TRP A 212
ARG A 341
LEU A 451
TRP A 453
 B3P  A 652 ( 3.9A)
None
B3P  A 652 (-2.8A)
None
None
 0.44A 1gahA-6fhvA:
62.7		 1gahA-6fhvA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 5 ALA A  67
TRP A 207
ARG A 335
LEU A 447
TRP A 449
 ACR  A 801 (-3.5A)
None
ACR  A 801 (-2.8A)
None
None
 0.39A 1gahA-6fhwA:
60.5		 1gahA-6fhwA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6frl TRYPTOPHAN
HALOGENASE
SUPERFAMILY

(Brevundimonas
sp. BAL3) 		no annotation 4 ALA A 138
SER A 477
ARG A 491
LEU A 139
 None
 1.15A 1gahA-6frlA:
undetectable		 1gahA-6frlA:
11.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6frv GLUCOAMYLASE

(Aspergillus
niger) 		no annotation 6 ALA A  63
SER A 143
TRP A 202
ARG A 329
LEU A 439
TRP A 441
 None
 0.53A 1gahA-6frvA:
68.4		 1gahA-6frvA:
83.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuz KINESIN LIGHT CHAIN
1,KINESIN LIGHT
CHAIN
1,C-JUN-AMINO-TERMIN
AL
KINASE-INTERACTING
PROTEIN 1

(Homo sapiens;
Mus musculus) 		no annotation 4 ALA A 239
SER A 225
ARG A 214
LEU A 243
 None
 1.17A 1gahA-6fuzA:
3.8		 1gahA-6fuzA:
12.38