SIMILAR PATTERNS OF AMINO ACIDS FOR 1G60_B_SAMB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ejb LUMAZINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00885
(DMRL_synthase) 		5 ASN A  50
ILE A  85
PRO A  86
GLY A  20
THR A  67
 None
 1.47A 1g60B-1ejbA:
0.0		 1g60B-1ejbA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ASN A 365
ASP A  42
ILE A  46
GLY A 102
THR A 100
 None
 1.34A 1g60B-1ewkA:
2.4		 1g60B-1ewkA:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		11 ASN A  11
CYH A  12
ASP A  30
TRP A  40
PRO A 196
PHE A 220
GLY A 222
THR A 225
MET A 242
ASN A 243
TYR A 246
 SAM  A 500 (-4.1A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.7A)
SAM  A 500 (-3.8A)
SAM  A 500 (-4.0A)
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.6A)
None
SAM  A 500 (-4.4A)
 0.13A 1g60B-1g60A:
38.3		 1g60B-1g60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		6 ASP A  30
TRP A  40
GLY A 222
THR A 226
MET A 242
ASN A 243
 SAM  A 500 (-3.7A)
SAM  A 500 (-3.8A)
SAM  A 500 (-3.2A)
None
SAM  A 500 (-3.6A)
None
 1.47A 1g60B-1g60A:
38.3		 1g60B-1g60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		5 CYH A 219
TRP A  40
PHE A 220
ASN A 243
TYR A 246
 None
SAM  A 500 (-3.8A)
SAM  A 500 (-4.6A)
None
SAM  A 500 (-4.4A)
 1.42A 1g60B-1g60A:
38.3		 1g60B-1g60A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 5 ASN O  31
ASP O 101
ILE O 143
PHE O  99
GLY O 106
 NDP  O6335 (-3.5A)
None
None
NDP  O6335 (-4.9A)
None
 1.48A 1g60B-1jn0O:
0.0		 1g60B-1jn0O:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		5 ASN A  19
ILE A 230
PRO A 157
GLY A 168
THR A 188
 None
 1.47A 1g60B-1lf9A:
undetectable		 1g60B-1lf9A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 ILE A 194
PRO A 325
PHE A 302
THR A 298
ASN A 196
 None
 1.31A 1g60B-1umfA:
undetectable		 1g60B-1umfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		5 ASN A  62
ASP A  28
PRO A 152
GLY A  16
ASN A 430
 None
 1.39A 1g60B-1uwiA:
1.5		 1g60B-1uwiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 ASN A  52
ILE A  67
GLY A 574
THR A  45
TYR A 534
 None
 1.34A 1g60B-1w6sA:
undetectable		 1g60B-1w6sA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 ASN A 237
PRO A 494
GLY A  92
THR A 457
ASN A 128
 None
 1.18A 1g60B-2eaeA:
undetectable		 1g60B-2eaeA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ASP A  86
ILE A 143
PHE A 117
GLY A  84
THR A 120
 None
 0.98A 1g60B-2fuvA:
undetectable		 1g60B-2fuvA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		5 CYH A 222
ILE A 190
PHE A 218
GLY A 214
THR A 211
 None
 1.48A 1g60B-2i7pA:
undetectable		 1g60B-2i7pA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		5 ASP A 160
ILE A  64
PRO A 166
MET A  71
ASN A  68
 None
 1.15A 1g60B-2ixoA:
undetectable		 1g60B-2ixoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		5 ILE A 225
PHE A 189
GLY A 175
MET A 183
TYR A 178
 None
 1.45A 1g60B-2y6iA:
undetectable		 1g60B-2y6iA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dao PUTATIVE PHOSPHATE

([Eubacterium]
rectale) 		PF08282
(Hydrolase_3) 		5 CYH A 162
ASP A 103
TRP A 183
ILE A 121
PRO A 120
 None
None
1PE  A 265 ( 4.0A)
None
None
 1.44A 1g60B-3daoA:
4.2		 1g60B-3daoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 709
PHE A 685
GLY A 687
THR A 706
TYR A 646
 None
 1.48A 1g60B-3ddrA:
undetectable		 1g60B-3ddrA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 ASN A 189
TRP A 184
ILE A 176
GLY A 231
THR A 331
 None
 1.14A 1g60B-3ejnA:
undetectable		 1g60B-3ejnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 ASN A 317
ASP A 500
ILE A 332
PRO A 330
GLY A 328
 None
 1.13A 1g60B-3i6sA:
undetectable		 1g60B-3i6sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ASN A  31
ASP A 101
ILE A 143
PHE A  99
GLY A 106
 NAD  A 335 ( 4.3A)
None
None
NAD  A 335 (-4.4A)
None
 1.48A 1g60B-3k2bA:
undetectable		 1g60B-3k2bA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2r GLIOMA
PATHOGENESIS-RELATED
PROTEIN 1

(Homo sapiens) 		PF00188
(CAP) 		5 ASN A  99
ILE A 107
PRO A 106
PHE A 171
GLY A 103
 None
 1.33A 1g60B-3q2rA:
undetectable		 1g60B-3q2rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ASN A 551
ILE A 273
GLY A 240
THR A 247
TYR A 243
 None
None
None
FAD  A 702 (-4.6A)
None
 1.24A 1g60B-3vrbA:
undetectable		 1g60B-3vrbA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF05025
(RbsD_FucU) 		5 ILE A  85
PRO A  83
GLY A  87
MET A  92
TYR A  89
 None
 1.45A 1g60B-4a34A:
undetectable		 1g60B-4a34A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b16 CHITINASE LIKE
LECTIN

(Tamarindus
indica) 		PF00704
(Glyco_hydro_18) 		5 ASN A 161
ILE A 231
PRO A 232
PHE A 186
GLY A 229
 None
 1.10A 1g60B-4b16A:
undetectable		 1g60B-4b16A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		5 ASN A 218
PRO A 165
GLY A 171
THR A 168
TYR A 441
 None
 1.48A 1g60B-4c0hA:
1.8		 1g60B-4c0hA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 ASN A 274
ILE A  46
PRO A  48
PHE A  54
TYR A  64
 None
None
PG4  A 502 (-4.4A)
None
PG4  A 502 ( 4.0A)
 1.03A 1g60B-4gl0A:
undetectable		 1g60B-4gl0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASN L  30
ILE L  48
PHE L  71
GLY L  64
THR L  74
 None
 1.45A 1g60B-4jo2L:
undetectable		 1g60B-4jo2L:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING

(Bacteroides
vulgatus) 		PF12771
(SusD-like_2) 		5 ASN A 192
TRP A 187
ILE A 179
GLY A 234
ASN A 186
 None
 1.08A 1g60B-4lerA:
undetectable		 1g60B-4lerA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 ASN A 555
ASP A 451
ILE A 456
GLY A 449
TYR A 468
 None
 1.11A 1g60B-4mzdA:
undetectable		 1g60B-4mzdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nji 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Burkholderia
multivorans) 		PF13394
(Fer4_14) 		5 ASN A  32
CYH A  31
ASP A  52
PHE A  53
GLY A  55
 None
SF4  A 301 (-2.3A)
None
SF4  A 301 ( 4.6A)
None
 1.38A 1g60B-4njiA:
undetectable		 1g60B-4njiA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxh HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TRER

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 ASN A  78
ILE A 310
PRO A 311
GLY A 283
THR A 313
 None
 1.41A 1g60B-4xxhA:
3.2		 1g60B-4xxhA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0v MATRIX PROTEIN VP40

(Marburg
marburgvirus) 		PF07447
(VP40) 		5 ASN A 142
ILE A 151
PRO A 152
PHE A 145
TYR A 162
 None
 1.47A 1g60B-5b0vA:
undetectable		 1g60B-5b0vA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		5 ASP A  29
PHE A 195
GLY A 197
THR A 200
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
 0.43A 1g60B-5hfjA:
23.1		 1g60B-5hfjA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8k HHH1 FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASN L  32
ILE L  50
PHE L  73
GLY L  66
THR L  76
 None
 1.44A 1g60B-5i8kL:
undetectable		 1g60B-5i8kL:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8o HMM5 ANTIBODY LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASN L  32
ILE L  50
PHE L  73
GLY L  66
THR L  76
 None
 1.48A 1g60B-5i8oL:
undetectable		 1g60B-5i8oL:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m63 L CHAIN OF FAB
NVS-1-19-5

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASN L  54
ILE L  72
PHE L  95
GLY L  88
THR L  98
 BGC  L 303 ( 4.7A)
None
None
None
None
 1.48A 1g60B-5m63L:
undetectable		 1g60B-5m63L:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj3 INTERLEUKIN-12
SUBUNIT BETA

(Homo sapiens) 		PF10420
(IL12p40_C) 		5 ILE A 233
PRO A 235
PHE A 140
THR A 261
TYR A 136
 None
 1.03A 1g60B-5mj3A:
undetectable		 1g60B-5mj3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 5 ASN A 130
ASP A 269
GLY A 206
THR A 271
MET A 202
 None
ZN  A 402 (-1.9A)
None
None
None
 1.35A 1g60B-6eslA:
1.8		 1g60B-6eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		5 ASP A  77
ILE A  18
THR A  82
MET A 107
ASN A 106
 None
 1.23A 1g60B-6fivA:
undetectable		 1g60B-6fivA:
19.42