SIMILAR PATTERNS OF AMINO ACIDS FOR 1G60_A_SAMA500_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		12 ASN A  11
CYH A  12
ASP A  30
TRP A  40
PRO A 196
PHE A 220
GLY A 222
SER A 223
THR A 225
MET A 242
ASN A 243
TYR A 246
 SAM  A 500 (-4.1A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.7A)
SAM  A 500 (-3.8A)
SAM  A 500 (-4.0A)
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-2.8A)
SAM  A 500 (-3.4A)
SAM  A 500 (-3.6A)
None
SAM  A 500 (-4.4A)
 0.00A 1g60A-1g60A:
41.1		 1g60A-1g60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		6 ASP A  30
TRP A  40
GLY A 222
THR A 226
MET A 242
ASN A 243
 SAM  A 500 (-3.7A)
SAM  A 500 (-3.8A)
SAM  A 500 (-3.2A)
None
SAM  A 500 (-3.6A)
None
 1.47A 1g60A-1g60A:
41.1		 1g60A-1g60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		5 CYH A 219
TRP A  40
PHE A 220
ASN A 243
TYR A 246
 None
SAM  A 500 (-3.8A)
SAM  A 500 (-4.6A)
None
SAM  A 500 (-4.4A)
 1.46A 1g60A-1g60A:
41.1		 1g60A-1g60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		5 CYH A  47
ASP A  65
PHE A 250
GLY A 252
SER A 253
 SAM  A 401 (-3.8A)
SAM  A 401 (-3.3A)
SAM  A 401 (-4.7A)
SAM  A 401 (-3.3A)
SAM  A 401 (-2.8A)
 0.26A 1g60A-1nw5A:
25.2		 1g60A-1nw5A:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA
FAB 17-IA

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		5 ASN H  35
GLY L  99
SER L 100
THR L   5
TYR L  87
 None
 1.42A 1g60A-1rvfH:
undetectable		 1g60A-1rvfH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 PRO A 325
PHE A 302
SER A 199
THR A 298
ASN A 196
 None
 1.49A 1g60A-1umfA:
undetectable		 1g60A-1umfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		5 ASN A  62
ASP A  28
PRO A 152
GLY A  16
ASN A 430
 None
 1.37A 1g60A-1uwiA:
undetectable		 1g60A-1uwiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASN A 393
PHE A 120
GLY A 123
SER A 124
THR A 126
 None
 1.41A 1g60A-1yfmA:
undetectable		 1g60A-1yfmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 ASN A 237
PRO A 494
GLY A  92
THR A 457
ASN A 128
 None
 1.16A 1g60A-2eaeA:
undetectable		 1g60A-2eaeA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes) 		PF03602
(Cons_hypoth95) 		5 ASP A 117
PHE A  49
GLY A  51
SER A  52
ASN A  73
 None
 0.90A 1g60A-2esrA:
5.2		 1g60A-2esrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		6 ASN A 109
ASP A 127
PHE A  60
GLY A  62
SER A  63
MET A  83
 CL  A 401 (-4.7A)
None
None
None
None
None
 0.90A 1g60A-2fpoA:
3.0		 1g60A-2fpoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 ASN A 352
PRO A 358
GLY A 384
SER A 385
TYR A 355
 None
 1.36A 1g60A-2p2mA:
2.3		 1g60A-2p2mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		5 ASN A 158
CYH A 595
PRO A 320
GLY A 165
SER A 166
 None
 1.31A 1g60A-2pggA:
undetectable		 1g60A-2pggA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7l FAB LIGHT CHAIN

(unidentified) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE B  62
GLY B  64
SER B  65
THR B  72
ASN B  53
 None
 1.22A 1g60A-2x7lB:
undetectable		 1g60A-2x7lB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 ASN A 195
TRP A 190
GLY A 175
SER A 176
THR A 178
 None
 1.41A 1g60A-3ahyA:
undetectable		 1g60A-3ahyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)

(Geobacter
metallireducens) 		no annotation 5 ASP A 254
GLY A 258
SER A 259
ASN A 281
TYR A 284
 None
CL  A   1 ( 4.7A)
CL  A   1 (-4.5A)
None
None
 1.40A 1g60A-3e05A:
4.1		 1g60A-3e05A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR

(Staphylococcus
aureus) 		PF13377
(Peripla_BP_3) 		5 ASN A 173
ASP A 252
PRO A  77
PHE A 279
SER A 282
 GOL  A 349 (-3.2A)
GOL  A 348 (-3.6A)
None
None
None
 1.05A 1g60A-3hcwA:
2.4		 1g60A-3hcwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3huu TRANSCRIPTION
REGULATOR LIKE
PROTEIN

(Staphylococcus
haemolyticus) 		PF13377
(Peripla_BP_3) 		5 ASP A 208
PRO A  38
PHE A 235
SER A 238
ASN A 252
 None
 0.98A 1g60A-3huuA:
2.9		 1g60A-3huuA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ASN A  94
GLY A 441
SER A 443
MET A  95
TYR A 447
 None
ACT  A  12 (-3.5A)
ACT  A  12 (-2.6A)
None
None
 1.32A 1g60A-3l22A:
undetectable		 1g60A-3l22A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PRO A 242
PHE A  10
GLY A 276
THR A 109
ASN A 297
 None
FAD  A 500 (-4.6A)
FAD  A 500 (-3.5A)
FAD  A 500 (-3.6A)
None
 1.35A 1g60A-3oc4A:
undetectable		 1g60A-3oc4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		5 CYH A 221
PHE A 233
GLY A 235
SER A 236
THR A 237
 None
 1.32A 1g60A-3pg1A:
undetectable		 1g60A-3pg1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2r GLIOMA
PATHOGENESIS-RELATED
PROTEIN 1

(Homo sapiens) 		PF00188
(CAP) 		5 ASN A  99
PRO A 106
PHE A 171
GLY A 103
SER A 104
 None
 1.50A 1g60A-3q2rA:
undetectable		 1g60A-3q2rA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASN A 366
PHE A  98
GLY A 101
SER A 102
THR A 104
 None
 1.36A 1g60A-3rd8A:
undetectable		 1g60A-3rd8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM

(Mycobacteroides
abscessus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASN A 367
PHE A  97
GLY A 100
SER A 101
THR A 103
 None
None
None
LMR  A 468 (-2.9A)
LMR  A 468 (-2.9A)
 1.33A 1g60A-3rrpA:
undetectable		 1g60A-3rrpA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		5 ASN A 204
PRO A 253
GLY A 224
SER A 225
THR A 226
 None
 1.37A 1g60A-3s5tA:
undetectable		 1g60A-3s5tA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 CYH A 598
ASP A 615
PHE A 546
MET A 569
TYR A 573
 SAM  A 802 (-3.3A)
None
SAM  A 802 (-4.5A)
SAM  A 802 (-3.2A)
SAM  A 802 (-4.6A)
 1.45A 1g60A-3v8vA:
3.8		 1g60A-3v8vA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbd SINGLE CHAIN FV
FRAGMENT OF MAB735

(Mus musculus) 		PF07686
(V-set) 		5 PHE A  67
GLY A  69
SER A  70
THR A  77
ASN A  58
 None
 1.14A 1g60A-3wbdA:
undetectable		 1g60A-3wbdA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ASN A 368
PHE A 100
GLY A 103
SER A 104
THR A 106
 None
 1.39A 1g60A-4apbA:
undetectable		 1g60A-4apbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 ASN A  95
CYH A  20
GLY A  83
SER A  84
THR A  86
 None
 1.26A 1g60A-4ggpA:
2.2		 1g60A-4ggpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nji 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Burkholderia
multivorans) 		PF13394
(Fer4_14) 		5 ASN A  32
CYH A  31
ASP A  52
PHE A  53
GLY A  55
 None
SF4  A 301 (-2.3A)
None
SF4  A 301 ( 4.6A)
None
 1.38A 1g60A-4njiA:
2.2		 1g60A-4njiA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouo ANTI BLA G 1 SCFV

(Gallus gallus) 		PF07686
(V-set) 		5 PHE A  61
GLY A  63
SER A  64
THR A  71
ASN A  52
 None
 1.23A 1g60A-4ouoA:
undetectable		 1g60A-4ouoA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE A  61
GLY A  63
SER A  64
THR A  71
ASN A  52
 None
 1.20A 1g60A-4qciA:
undetectable		 1g60A-4qciA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 5 CYH A 467
ASP A 437
GLY A 435
SER A 429
THR A 433
 None
SO4  A 809 ( 4.7A)
None
None
None
 1.28A 1g60A-4y9vA:
undetectable		 1g60A-4y9vA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		5 ASP A 123
PHE A 441
GLY A 443
SER A 444
THR A 446
 None
 0.36A 1g60A-4zcfA:
21.2		 1g60A-4zcfA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2y RNA POLYMERASE II
SUBUNIT B1 CTD
PHOSPHATASE RTR1

(Saccharomyces
cerevisiae) 		PF04181
(RPAP2_Rtr1) 		5 ASN A  70
CYH A  38
ASP A   6
GLY A   0
SER A  -1
 None
 1.10A 1g60A-5c2yA:
undetectable		 1g60A-5c2yA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		6 ASP A  29
PHE A 195
GLY A 197
SER A 198
THR A 200
TYR A 221
 SAM  A 301 (-3.2A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
 0.48A 1g60A-5hfjA:
22.9		 1g60A-5hfjA:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		5 ASN A 435
TRP A 429
GLY A  65
SER A  81
THR A  77
 None
 1.23A 1g60A-5j5uA:
undetectable		 1g60A-5j5uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		5 ASP A 148
PRO A 423
GLY A 137
SER A 138
THR A 141
 None
 1.24A 1g60A-5l35A:
undetectable		 1g60A-5l35A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 5 ASP A 634
PHE A 635
GLY A 402
SER A 404
ASN A 412
 None
 1.46A 1g60A-6bdzA:
undetectable		 1g60A-6bdzA:
undetectable