SIMILAR PATTERNS OF AMINO ACIDS FOR 1G5Y_C_9CRC502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		5 LEU A 123
LEU A 132
ALA A  74
PHE A 150
ILE A 134
 None
 0.99A 1g5yC-1b0zA:
undetectable		 1g5yC-1b0zA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds9 OUTER ARM DYNEIN

(Chlamydomonas
reinhardtii) 		PF12799
(LRR_4) 		5 ALA A 137
LEU A 120
LEU A  88
ALA A  92
ILE A 111
 None
 1.23A 1g5yC-1ds9A:
undetectable		 1g5yC-1ds9A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flk TNF RECEPTOR
ASSOCIATED FACTOR 3

(Homo sapiens) 		no annotation 5 LEU A 444
PHE A 473
LEU A 407
PHE A 491
ILE A 490
 None
 0.91A 1g5yC-1flkA:
undetectable		 1g5yC-1flkA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7y STEM/LEAF LECTIN
DB58

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		5 ALA A  73
LEU A 179
LEU A 156
ALA A 157
ILE A  75
 None
 1.25A 1g5yC-1g7yA:
undetectable		 1g5yC-1g7yA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ALA A 222
ARG A 295
ALA A 271
PHE A 243
ILE A 228
 None
 1.19A 1g5yC-1g8kA:
undetectable		 1g5yC-1g8kA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hss 0.19 ALPHA-AMYLASE
INHIBITOR

(Triticum
aestivum) 		PF00234
(Tryp_alpha_amyl) 		5 ALA A  11
ARG A  21
LEU A  17
ALA A  16
ILE A  48
 None
 1.24A 1g5yC-1hssA:
undetectable		 1g5yC-1hssA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hss 0.19 ALPHA-AMYLASE
INHIBITOR

(Triticum
aestivum) 		PF00234
(Tryp_alpha_amyl) 		5 ALA A  11
SER A  63
ARG A  21
LEU A  17
ILE A  48
 None
 0.92A 1g5yC-1hssA:
undetectable		 1g5yC-1hssA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		5 ALA A  30
LEU A  99
LEU A  59
ALA A  33
ILE A  57
 None
None
None
ATP  A 510 (-3.9A)
None
 1.19A 1g5yC-1kh2A:
undetectable		 1g5yC-1kh2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ALA A 117
SER A 108
LEU A 135
ALA A 138
ILE A 120
 None
 1.27A 1g5yC-1kp0A:
undetectable		 1g5yC-1kp0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1j HEAT SHOCK PROTEASE
HTRA

(Thermotoga
maritima) 		PF13365
(Trypsin_2) 		5 ALA A 223
LEU A 194
LEU A 210
PHE A 235
ILE A 201
 None
 1.25A 1g5yC-1l1jA:
undetectable		 1g5yC-1l1jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqa TAS PROTEIN

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 ALA A 276
SER A 209
PHE A 295
ALA A 292
ILE A 280
 None
 1.14A 1g5yC-1lqaA:
undetectable		 1g5yC-1lqaA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 5 ALA T 177
LEU T 265
SER T 272
LEU T 310
ALA T 307
 None
 1.27A 1g5yC-1lthT:
undetectable		 1g5yC-1lthT:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 LEU A 115
ALA A 120
PHE A 168
PHE A 166
ILE A 169
 None
 1.26A 1g5yC-1m2wA:
undetectable		 1g5yC-1m2wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A  70
SER A  51
LEU A  47
ALA A 105
ILE A  93
 None
 1.24A 1g5yC-1mwoA:
undetectable		 1g5yC-1mwoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow1 SMART/HDAC1
ASSOCIATED REPRESSOR
PROTEIN

(Homo sapiens) 		PF07744
(SPOC) 		5 LEU A3595
SER A3594
LEU A3515
PHE A3629
ILE A3628
 None
 1.23A 1g5yC-1ow1A:
undetectable		 1g5yC-1ow1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		5 ALA E 256
LEU E 233
ALA E 248
PHE E 202
ILE E 201
 None
 1.05A 1g5yC-1pekE:
undetectable		 1g5yC-1pekE:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 5 ALA A  99
LEU A 271
ALA A 304
PHE A 322
ILE A 121
 None
None
None
HEM  A 999 (-4.5A)
None
 1.25A 1g5yC-1u5uA:
undetectable		 1g5yC-1u5uA:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 380
SER A 383
ARG A 387
LEU A 397
ALA A 398
ILE A 339
 MEI  A1001 (-3.8A)
None
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-3.8A)
 1.38A 1g5yC-1uhlA:
26.5		 1g5yC-1uhlA:
88.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 380
SER A 383
PHE A 384
ARG A 387
LEU A 397
ALA A 398
 MEI  A1001 (-3.8A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
 0.66A 1g5yC-1uhlA:
26.5		 1g5yC-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vya NUCLEOSIDE
DIPHOSPHATE KINASE

(Zea mays) 		PF00334
(NDK) 		5 LEU A  35
PHE A 131
LEU A 135
ALA A 136
PHE A  30
 None
 1.24A 1g5yC-1vyaA:
undetectable		 1g5yC-1vyaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ALA A 107
PHE A 208
ALA A 209
PHE A  86
ILE A 103
 None
 1.21A 1g5yC-1x2gA:
undetectable		 1g5yC-1x2gA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x46 HEMOGLOBIN COMPONENT
VII

(Tokunagayusurika
akamusi) 		PF00042
(Globin) 		5 ALA A 129
LEU A  14
SER A  17
LEU A 120
ALA A 124
 None
 1.00A 1g5yC-1x46A:
3.3		 1g5yC-1x46A:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 LEU A 283
PHE A 287
ARG A 290
LEU A 300
ALA A 301
 9CR  A 201 ( 4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
 0.59A 1g5yC-1xiuA:
27.6		 1g5yC-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 309
SER A 312
PHE A 313
ARG A 316
LEU A 326
ALA A 327
 9CR  A 801 (-4.2A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
 0.54A 1g5yC-1xlsA:
27.5		 1g5yC-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		5 ALA A 247
LEU B 285
LEU B 381
ALA A 290
PHE B 293
 None
 1.19A 1g5yC-2fpgA:
undetectable		 1g5yC-2fpgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3

(Homo sapiens) 		no annotation 5 LEU A 444
PHE A 473
LEU A 407
PHE A 491
ILE A 490
 None
 1.00A 1g5yC-2gkwA:
undetectable		 1g5yC-2gkwA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A  88
SER A  91
PHE A  92
ARG A  95
LEU A 105
ALA A 106
 None
 0.88A 1g5yC-2gl8A:
28.5		 1g5yC-2gl8A:
85.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9x PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		5 SER A  49
ARG A  35
LEU A  34
ALA A  46
ILE A  72
 None
 1.20A 1g5yC-2i9xA:
undetectable		 1g5yC-2i9xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ksn UBIQUITIN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF16455
(UBD) 		5 ALA A  77
LEU A 118
LEU A 100
ALA A 104
ILE A  93
 None
 1.22A 1g5yC-2ksnA:
undetectable		 1g5yC-2ksnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbx PARVALBUMIN BETA

(Gadus morhua) 		PF13499
(EF-hand_7) 		5 ALA A  17
PHE A  67
LEU A  78
ALA A  77
PHE A  30
 None
 1.12A 1g5yC-2mbxA:
undetectable		 1g5yC-2mbxA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
 None
 0.61A 1g5yC-2nxxA:
24.9		 1g5yC-2nxxA:
63.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 ALA A 132
LEU A 185
ARG A 221
PHE A 170
ILE A 162
 None
 1.15A 1g5yC-2o0xA:
undetectable		 1g5yC-2o0xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 ALA A 158
ARG A 104
LEU A 103
ALA A 100
ILE A 242
 None
 1.10A 1g5yC-2po4A:
undetectable		 1g5yC-2po4A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  61
LEU A 356
SER A 381
PHE A  78
ILE A  63
 None
 1.11A 1g5yC-2pp3A:
undetectable		 1g5yC-2pp3A:
23.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		5 LEU A 184
SER A 187
PHE A 188
ARG A 191
ALA A 202
 None
 0.35A 1g5yC-2q60A:
26.4		 1g5yC-2q60A:
71.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh5 MANNOSE-6-PHOSPHATE
ISOMERASE

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		5 ALA A  91
LEU A  53
PHE A  79
LEU A  81
ALA A 229
 None
 1.23A 1g5yC-2qh5A:
undetectable		 1g5yC-2qh5A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE

(Hahella
chejuensis) 		PF00701
(DHDPS) 		5 ALA A 255
LEU A 242
PHE A 243
ALA A 249
ILE A  10
 None
 1.24A 1g5yC-2rfgA:
undetectable		 1g5yC-2rfgA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt5 MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF07744
(SPOC) 		5 LEU A3595
SER A3594
LEU A3515
PHE A3629
ILE A3628
 None
 1.13A 1g5yC-2rt5A:
undetectable		 1g5yC-2rt5A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 LEU A 171
SER A 220
LEU A 201
ALA A 200
PHE A 162
 None
 1.19A 1g5yC-2uvfA:
undetectable		 1g5yC-2uvfA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 ALA A  32
LEU A 130
LEU A 236
ALA A 237
PHE A 132
 None
 1.07A 1g5yC-2w3pA:
undetectable		 1g5yC-2w3pA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 ALA B 335
LEU B 315
ALA B 312
PHE B 333
ILE B 283
 None
 1.08A 1g5yC-2xwuB:
undetectable		 1g5yC-2xwuB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zal L-ASPARAGINASE

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		5 ALA A   7
SER A  48
LEU B 191
ALA B 192
ILE B 280
 None
 1.08A 1g5yC-2zalA:
undetectable		 1g5yC-2zalA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 ALA A 362
ARG A  97
LEU A 396
PHE A 322
ILE A 321
 None
 1.10A 1g5yC-3bmaA:
undetectable		 1g5yC-3bmaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		5 ALA A   7
SER A  48
LEU A 191
ALA A 192
ILE A 280
 None
 1.14A 1g5yC-3c17A:
undetectable		 1g5yC-3c17A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF09383
(NIL) 		5 ALA C 150
SER C 178
LEU C 183
PHE C  88
ILE C  87
 None
 1.21A 1g5yC-3dhwC:
undetectable		 1g5yC-3dhwC:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 LEU A 309
SER A 312
PHE A 313
ARG A 316
LEU A 326
ALA A 327
 9CR  A7223 ( 4.4A)
9CR  A7223 ( 4.0A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.87A 1g5yC-3dzuA:
25.5		 1g5yC-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ALA A  28
SER A  13
LEU A   8
ALA A  31
ILE A   6
 None
BTN  A2001 (-2.7A)
None
None
None
 1.21A 1g5yC-3efsA:
undetectable		 1g5yC-3efsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eof PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		5 ALA A 113
LEU A  28
LEU A 119
ALA A 120
PHE A  32
 None
 1.21A 1g5yC-3eofA:
undetectable		 1g5yC-3eofA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esm UNCHARACTERIZED
PROTEIN

(Nocardia
farcinica) 		PF07987
(DUF1775) 		5 ALA A  81
SER A  70
LEU A  65
ALA A  91
PHE A 113
 None
SO4  A   1 (-2.6A)
None
None
None
 1.13A 1g5yC-3esmA:
undetectable		 1g5yC-3esmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		5 LEU A2342
LEU A2354
ALA A2350
PHE A2239
ILE A2403
 None
 1.22A 1g5yC-3jacA:
undetectable		 1g5yC-3jacA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 459
SER A 589
ALA A 586
PHE A 415
PHE A 414
 None
 1.28A 1g5yC-3l84A:
undetectable		 1g5yC-3l84A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		5 ALA A 132
LEU A  67
ALA A  66
PHE A  80
ILE A  77
 None
 0.91A 1g5yC-3lmaA:
undetectable		 1g5yC-3lmaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5h HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 235
LEU A 177
ALA A 176
PHE A 232
ILE A 179
 None
 1.10A 1g5yC-3m5hA:
undetectable		 1g5yC-3m5hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0t DIPEPTIDYL PEPTIDASE
2

(Homo sapiens) 		PF05577
(Peptidase_S28) 		5 LEU A 141
ARG A 147
PHE A  73
PHE A  72
ILE A  71
 None
 1.25A 1g5yC-3n0tA:
undetectable		 1g5yC-3n0tA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 146
PHE A 163
LEU A 156
ALA A 155
ILE A 131
 None
 1.24A 1g5yC-3n6rA:
undetectable		 1g5yC-3n6rA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9y ADRENODOXIN

(Homo sapiens) 		PF00111
(Fer2) 		5 ALA C  45
LEU C  30
SER C  28
LEU C  90
PHE C  43
 None
None
None
FES  C 150 ( 4.5A)
None
 1.24A 1g5yC-3n9yC:
undetectable		 1g5yC-3n9yC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Shewanella
loihica) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A  20
LEU A 110
SER A 112
ALA A  14
ILE A  29
 None
None
FAD  A 900 (-2.9A)
COA  A 901 (-3.3A)
None
 1.27A 1g5yC-3ntdA:
undetectable		 1g5yC-3ntdA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		5 ALA A 120
SER A  96
LEU A 102
ALA A 172
PHE A 140
 None
 1.18A 1g5yC-3obiA:
undetectable		 1g5yC-3obiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		5 LEU A 218
SER A 215
PHE A   4
PHE A   5
ILE A   6
 None
 1.19A 1g5yC-3of5A:
undetectable		 1g5yC-3of5A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		5 LEU A  96
LEU A 116
ALA A 119
PHE A  46
ILE A 171
 None
 1.20A 1g5yC-3p5nA:
2.9		 1g5yC-3p5nA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1x SERINE
ACETYLTRANSFERASE

(Entamoeba
histolytica) 		PF00132
(Hexapep) 		5 ALA A 109
SER A 121
ALA A 117
PHE A 130
PHE A 176
 None
 1.26A 1g5yC-3q1xA:
2.9		 1g5yC-3q1xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q34 YCEI-LIKE FAMILY
PROTEIN

(Pseudomonas
savastanoi) 		PF04264
(YceI) 		5 PHE A  86
ARG A 125
LEU A 124
PHE A  34
ILE A 155
 None
None
UQ8  A   1 ( 4.7A)
UQ8  A   1 (-3.8A)
UQ8  A   1 ( 4.8A)
 1.26A 1g5yC-3q34A:
undetectable		 1g5yC-3q34A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		5 ALA A  24
LEU A 169
LEU A 200
ALA A 197
ILE A  28
 None
 1.19A 1g5yC-3sweA:
undetectable		 1g5yC-3sweA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 LEU A 626
LEU A 554
PHE A 634
PHE A 656
ILE A 616
 None
 1.16A 1g5yC-3uvjA:
undetectable		 1g5yC-3uvjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 LEU A 333
SER A 315
PHE A 332
PHE A 217
ILE A 165
 None
 0.97A 1g5yC-3v8uA:
undetectable		 1g5yC-3v8uA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm8 PROBABLE DNA
DC->DU-EDITING
ENZYME APOBEC-3C

(Homo sapiens) 		PF08210
(APOBEC_N) 		5 ALA A 101
LEU A  72
PHE A  71
LEU A  35
ALA A  67
 None
 1.18A 1g5yC-3vm8A:
undetectable		 1g5yC-3vm8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A 231
SER A 170
LEU A 192
ALA A 197
PHE A 234
 None
 1.19A 1g5yC-3vpxA:
undetectable		 1g5yC-3vpxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 ALA A 128
SER A 154
PHE A 155
ALA A  77
ILE A  73
 None
 1.17A 1g5yC-4a27A:
undetectable		 1g5yC-4a27A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		5 ALA A 395
LEU A 464
SER A 467
LEU A 390
ILE A 391
 None
 1.26A 1g5yC-4dyoA:
undetectable		 1g5yC-4dyoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 ALA A1114
LEU A1148
LEU A 709
ALA A 712
ILE A1188
 None
 1.25A 1g5yC-4fwtA:
undetectable		 1g5yC-4fwtA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g88 OUTER MEMBRANE
PROTEIN OMP38

(Acinetobacter
baumannii) 		PF00691
(OmpA) 		5 ALA A 253
LEU A 305
SER A 306
ALA A 333
ILE A 249
 None
 1.08A 1g5yC-4g88A:
undetectable		 1g5yC-4g88A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 ALA A 184
LEU A 208
LEU A 199
ALA A 200
ILE A 174
 None
 1.12A 1g5yC-4i8pA:
undetectable		 1g5yC-4i8pA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 LEU D 309
SER D 312
PHE D 313
ARG D 316
LEU D 326
ALA D 327
 None
 0.67A 1g5yC-4j5xD:
25.4		 1g5yC-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 ALA A  13
LEU A 232
SER A 219
PHE A 222
ILE A  10
 None
BGC  A 601 (-3.8A)
None
None
None
 1.22A 1g5yC-4jsoA:
undetectable		 1g5yC-4jsoA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr ESPG5

(Mycobacterium
tuberculosis) 		PF14011
(ESX-1_EspG) 		5 ALA C 273
LEU C 242
SER C 240
ALA C 269
ILE C 252
 None
 1.11A 1g5yC-4kxrC:
undetectable		 1g5yC-4kxrC:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 259
LEU A 278
SER A 253
LEU A 287
ILE A 286
 None
 1.22A 1g5yC-4ln1A:
undetectable		 1g5yC-4ln1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		5 LEU A 626
LEU A 554
PHE A 634
PHE A 656
ILE A 616
 None
 1.16A 1g5yC-4ni2A:
undetectable		 1g5yC-4ni2A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ALA A 269
LEU A 289
LEU A 262
ALA A 260
ILE A 266
 None
None
None
None
GOL  A 504 ( 4.0A)
 1.26A 1g5yC-4o6rA:
undetectable		 1g5yC-4o6rA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcz ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 ALA A  12
LEU A  97
SER A 197
LEU A 192
ALA A 193
 None
 1.20A 1g5yC-4wczA:
undetectable		 1g5yC-4wczA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 ALA A  38
LEU A  54
ALA A  42
PHE A 187
ILE A  23
 None
 1.13A 1g5yC-4xmvA:
undetectable		 1g5yC-4xmvA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru HEN1
RNL

(Capnocytophaga
gingivalis) 		PF16542
(PNKP_ligase)
no annotation 		5 ALA C  28
LEU B 155
SER B 154
PHE B 201
ILE B 198
 None
 1.24A 1g5yC-4xruC:
undetectable		 1g5yC-4xruC:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfl AMIDOHYDROLASE EGTC

(Mycolicibacterium
smegmatis) 		PF13522
(GATase_6) 		5 LEU A 140
SER A 143
LEU A 149
ALA A 148
ILE A 153
 None
 1.02A 1g5yC-4zflA:
undetectable		 1g5yC-4zflA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A1180
ARG A1204
LEU A1203
ALA A1200
PHE A1238
 None
 1.27A 1g5yC-4zxiA:
undetectable		 1g5yC-4zxiA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1h CYSTATHIONINE
BETA-SYNTHASE

(Lactobacillus
plantarum) 		PF00291
(PALP) 		5 ALA A  30
LEU A 252
LEU A 272
ALA A 269
ILE A  28
 None
 1.25A 1g5yC-5b1hA:
undetectable		 1g5yC-5b1hA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnd ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
epidermidis) 		no annotation 5 PHE A 385
LEU A 338
ALA A 337
PHE A 491
ILE A 501
 None
 1.05A 1g5yC-5bndA:
undetectable		 1g5yC-5bndA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		5 ALA A  81
SER A 132
PHE A 133
LEU A 137
PHE A  83
 None
 1.27A 1g5yC-5g53A:
undetectable		 1g5yC-5g53A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j62 PUTATIVE REDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		5 ALA A 121
PHE A  41
LEU A 114
ALA A  43
ILE A 118
 None
 1.22A 1g5yC-5j62A:
undetectable		 1g5yC-5j62A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		6 ALA A 132
LEU A 185
SER A 188
LEU A 139
ALA A 138
ILE A 100
 None
 1.39A 1g5yC-5jrjA:
undetectable		 1g5yC-5jrjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 PHE A2606
LEU A2609
ALA A2608
PHE A2662
PHE A2708
 None
 1.00A 1g5yC-5nugA:
undetectable		 1g5yC-5nugA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opi TAP BINDING
PROTEIN-LIKE VARIANT

(Homo sapiens) 		no annotation 5 ALA C  79
SER C 197
PHE C 173
ALA C 199
PHE C 124
 None
 1.15A 1g5yC-5opiC:
undetectable		 1g5yC-5opiC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 162
PHE A 228
LEU A 183
ALA A 184
ILE A 172
 None
 1.22A 1g5yC-5suiA:
undetectable		 1g5yC-5suiA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		5 ALA A 587
LEU A 598
ALA A 595
PHE A 535
ILE A 538
 None
 1.04A 1g5yC-5txeA:
undetectable		 1g5yC-5txeA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 LEU A 628
SER A 627
LEU A 633
PHE A 463
ILE A 667
 None
 1.19A 1g5yC-5u89A:
undetectable		 1g5yC-5u89A:
12.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 6 LEU A 309
SER A 312
PHE A 313
ARG A 316
LEU A 326
ALA A 327
 9CR  A 503 (-3.7A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
 0.53A 1g5yC-5uanA:
25.5		 1g5yC-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 LEU A 419
ARG A 417
LEU A 414
PHE A  52
PHE A  54
 None
 1.26A 1g5yC-5ur2A:
undetectable		 1g5yC-5ur2A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		no annotation 5 ALA A 284
LEU A 255
PHE A 254
LEU A 218
ALA A 250
 None
 1.23A 1g5yC-5w2mA:
undetectable		 1g5yC-5w2mA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t 50S RIBOSOMAL
PROTEIN L4,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00573
(Ribosomal_L4) 		5 ALA E 168
LEU E 240
LEU E 161
ALA E 160
ILE E 165
 None
 1.25A 1g5yC-5x8tE:
undetectable		 1g5yC-5x8tE:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 5 ALA A  74
LEU A  71
PHE A 160
PHE A 159
ILE A  80
 None
None
None
P6G  A 503 (-4.0A)
P6G  A 503 ( 4.7A)
 1.21A 1g5yC-5xj1A:
undetectable		 1g5yC-5xj1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN
OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 ALA A  32
LEU C 166
LEU A 113
ALA C 161
ILE A 110
 None
 1.15A 1g5yC-5xn6A:
undetectable		 1g5yC-5xn6A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT 6
MITOCHONDRIAL ATP
SYNTHASE SUBUNIT C

(Polytomella sp.
Pringsheim
198.80) 		no annotation 5 LEU M 236
SER M 235
ALA A 108
PHE M 299
ILE M 301
 None
 1.28A 1g5yC-6f36M:
undetectable		 1g5yC-6f36M:
17.17