SIMILAR PATTERNS OF AMINO ACIDS FOR 1G5Y_B_9CRB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 ILE A 241
ALA A 244
LEU A 290
LEU A 223
LEU A 345
 None
 1.30A 1g5yB-1ct9A:
undetectable		 1g5yB-1ct9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbn PROTEIN
(LEUKOAGGLUTININ)

(Maackia
amurensis) 		PF00139
(Lectin_legB) 		5 ILE A 146
LEU A 182
LEU A  93
LEU A 111
PHE A  91
 None
 1.11A 1g5yB-1dbnA:
undetectable		 1g5yB-1dbnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		5 ILE A 100
ALA A 103
LEU A  35
ALA A  34
ILE A  99
 None
 1.26A 1g5yB-1dofA:
0.4		 1g5yB-1dofA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dz3 STAGE 0 SPORULATION
PROTEIN A

(Geobacillus
stearothermophilus) 		PF00072
(Response_reg) 		5 ILE A  51
LEU A  18
LEU A 105
PHE A 103
ILE A  81
 None
 1.27A 1g5yB-1dz3A:
0.5		 1g5yB-1dz3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6b GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		5 ALA A 146
LEU A 192
ALA A 167
PHE A 144
ILE A 106
 None
 1.27A 1g5yB-1e6bA:
undetectable		 1g5yB-1e6bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 ILE A 429
ALA A 431
TRP A 290
ALA A 387
ILE A 379
 None
 1.25A 1g5yB-1ecgA:
undetectable		 1g5yB-1ecgA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A 272
LEU A 172
LEU A 196
ALA A 197
PHE A 189
 None
 1.20A 1g5yB-1fotA:
undetectable		 1g5yB-1fotA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 ILE A  82
LEU A  21
LEU A   6
LEU A   4
ILE A 117
 None
 1.30A 1g5yB-1fy2A:
0.0		 1g5yB-1fy2A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ALA A 472
LEU A 488
ALA A 487
LEU A 466
ILE A 468
 None
 1.20A 1g5yB-1gytA:
0.0		 1g5yB-1gytA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzs SOPE

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		5 ILE B 231
ALA B 147
ALA B 167
LEU B 141
ILE B 144
 None
 1.16A 1g5yB-1gzsB:
0.0		 1g5yB-1gzsB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsl HISTIDINE-BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		5 ILE A  73
LEU A 199
LEU A 210
LEU A  33
ALA A  34
 None
 1.06A 1g5yB-1hslA:
undetectable		 1g5yB-1hslA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 LEU A 100
LEU A  75
ALA A  74
PHE A 258
LEU A 237
 None
 0.99A 1g5yB-1ihpA:
undetectable		 1g5yB-1ihpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		5 ILE A 302
ALA A 240
LEU A 241
LEU A 291
ALA A 286
 None
 1.07A 1g5yB-1l5aA:
undetectable		 1g5yB-1l5aA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		5 LEU A  55
LEU A  79
LEU A  33
ALA A  32
LEU A  98
 None
 1.24A 1g5yB-1qzzA:
undetectable		 1g5yB-1qzzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		5 ALA A 276
LEU A 322
LEU A 373
LEU A 399
LEU A 282
 None
 1.24A 1g5yB-1rq1A:
undetectable		 1g5yB-1rq1A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 ALA A 352
LEU A 340
LEU A  22
ALA A  23
PHE A 358
 None
 0.89A 1g5yB-1rqgA:
undetectable		 1g5yB-1rqgA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 522
TRP A 376
ARG A 387
ALA A 398
ILE A 339
 None
None
MEI  A1001 (-3.6A)
MEI  A1001 (-3.4A)
MEI  A1001 (-3.8A)
 1.30A 1g5yB-1uhlA:
26.4		 1g5yB-1uhlA:
88.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 376
LEU A 380
ARG A 387
LEU A 397
ALA A 398
 None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
 0.65A 1g5yB-1uhlA:
26.4		 1g5yB-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01207
(Dus) 		5 LEU A 202
ALA A 201
PHE A 229
LEU A 230
ILE A 226
 None
 0.95A 1g5yB-1vhnA:
undetectable		 1g5yB-1vhnA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ALA A 282
LEU A 252
LEU A 262
ALA A 261
LEU A 248
 None
 0.99A 1g5yB-1w78A:
undetectable		 1g5yB-1w78A:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		5 TRP A 279
LEU A 283
ARG A 290
LEU A 300
ALA A 301
 None
9CR  A 201 ( 4.1A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
 0.55A 1g5yB-1xiuA:
27.4		 1g5yB-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 305
LEU A 309
ARG A 316
LEU A 326
ALA A 327
 None
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
 0.49A 1g5yB-1xlsA:
27.5		 1g5yB-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		5 ILE A  76
ALA A  88
LEU A  89
LEU A 111
ILE A 204
 None
 1.18A 1g5yB-1xp8A:
undetectable		 1g5yB-1xp8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		5 LEU A 526
TRP A 495
LEU A 498
ALA A 469
ILE A 558
 None
 1.23A 1g5yB-1yvlA:
undetectable		 1g5yB-1yvlA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmn METALLO-BETA-LACTAMA
SE

(Bradyrhizobium
diazoefficiens) 		PF00753
(Lactamase_B) 		5 ILE A 113
ALA A 119
LEU A 164
LEU A  66
ILE A  94
 None
 1.26A 1g5yB-2gmnA:
undetectable		 1g5yB-2gmnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF16914
(TetR_C_12) 		5 ILE A 159
LEU A  97
LEU A 199
LEU A 148
ILE A 145
 None
EDO  A 302 (-4.8A)
None
None
None
 1.07A 1g5yB-2hkuA:
2.8		 1g5yB-2hkuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iun AVIAN ADENOVIRUS
CELO LONG FIBRE

(Fowl
aviadenovirus A) 		PF16812
(AdHead_fibreRBD) 		5 ILE A 653
ALA A 614
LEU A 595
LEU A 671
ILE A 600
 None
 1.29A 1g5yB-2iunA:
undetectable		 1g5yB-2iunA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		5 ALA A   3
LEU A  59
ALA A  58
LEU A  66
ILE A  69
 None
 0.95A 1g5yB-2ivpA:
undetectable		 1g5yB-2ivpA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		5 ALA A  51
LEU A 361
ALA A 122
LEU A 142
ILE A  52
 None
 1.26A 1g5yB-2nlzA:
undetectable		 1g5yB-2nlzA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr7 SECRETION ACTIVATOR
PROTEIN, PUTATIVE

(Porphyromonas
gingivalis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		5 ILE A 109
ALA A 141
LEU A 186
PHE A 139
ILE A 138
 None
 1.27A 1g5yB-2nr7A:
undetectable		 1g5yB-2nr7A:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 ALA A 423
LEU A 454
LEU A 339
ALA A 350
ILE A 363
 None
 1.24A 1g5yB-2ocaA:
undetectable		 1g5yB-2ocaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		5 ILE A   3
ALA A  78
LEU A  75
LEU A  24
ILE A  82
 None
 0.93A 1g5yB-2pfrA:
undetectable		 1g5yB-2pfrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q34 CURF

(Moorea
producens) 		PF00378
(ECH_1) 		5 ALA A 151
LEU A 160
ALA A 165
LEU A 124
ILE A 155
 None
 1.05A 1g5yB-2q34A:
undetectable		 1g5yB-2q34A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 243
ALA A 291
LEU A 298
LEU A 253
ILE A 247
 None
 1.24A 1g5yB-2qymA:
undetectable		 1g5yB-2qymA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcv SUPEROXIDE DISMUTASE
[MN]

(Bacillus
subtilis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ALA A  42
LEU A  39
LEU A  57
ALA A  48
ILE A  68
 None
 1.30A 1g5yB-2rcvA:
undetectable		 1g5yB-2rcvA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 ALA A 158
LEU A 159
LEU A 298
ALA A 297
LEU A 271
 None
 1.08A 1g5yB-2vwqA:
undetectable		 1g5yB-2vwqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 ALA A 515
LEU A 482
ALA A 483
PHE A 564
LEU A 480
 None
 1.27A 1g5yB-2y2wA:
undetectable		 1g5yB-2y2wA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ALA A 308
LEU A 416
LEU A 397
ALA A 398
LEU A 314
 None
 1.28A 1g5yB-2z0fA:
undetectable		 1g5yB-2z0fA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3j BLASTICIDIN-S
DEAMINASE

(Aspergillus
terreus) 		PF00383
(dCMP_cyt_deam_1) 		5 ILE A 118
ALA A 104
LEU A  10
LEU A  71
ILE A 102
 None
 1.28A 1g5yB-2z3jA:
undetectable		 1g5yB-2z3jA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 413
LEU A 458
ARG A 364
PHE A 494
ILE A 414
 None
 1.26A 1g5yB-3a2fA:
undetectable		 1g5yB-3a2fA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		5 ILE A 650
ALA A 597
LEU A 609
ALA A 605
ILE A 620
 None
 1.18A 1g5yB-3cf4A:
undetectable		 1g5yB-3cf4A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04051
(TRAPP) 		5 LEU B 191
LEU B 180
PHE B 240
LEU B 241
ILE B 237
 None
 1.01A 1g5yB-3cueB:
undetectable		 1g5yB-3cueB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3d LYSOZYME

(Escherichia
virus Lambda) 		PF00959
(Phage_lysozyme) 		5 ALA A 104
LEU A  12
ALA A  10
LEU A  96
ILE A  99
 None
 1.10A 1g5yB-3d3dA:
undetectable		 1g5yB-3d3dA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 TRP A 305
LEU A 309
ARG A 316
LEU A 326
ALA A 327
 None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.56A 1g5yB-3dzuA:
25.5		 1g5yB-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ALA A  64
LEU A 322
LEU A 333
ALA A  56
ILE A  72
 None
 1.30A 1g5yB-3fgqA:
undetectable		 1g5yB-3fgqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 ALA 3 357
LEU 3 641
LEU 3 664
ALA 3 663
LEU 3 351
 None
 1.23A 1g5yB-3i9v3:
undetectable		 1g5yB-3i9v3:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		5 ALA A 581
LEU A 677
LEU A1010
LEU A1015
LEU A 530
 None
 1.07A 1g5yB-3jbyA:
undetectable		 1g5yB-3jbyA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 5 ILE B 128
ALA B 131
LEU B   3
ALA B 110
ILE B 161
 None
 1.17A 1g5yB-3jruB:
undetectable		 1g5yB-3jruB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l77 SHORT-CHAIN ALCOHOL
DEHYDROGENASE

(Thermococcus
sibiricus) 		PF00106
(adh_short) 		5 ALA A   9
LEU A  45
LEU A  21
ALA A  20
ILE A   6
 None
 1.27A 1g5yB-3l77A:
undetectable		 1g5yB-3l77A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ILE A 667
ALA A 732
LEU A 729
LEU A 790
ARG A 736
 None
 1.06A 1g5yB-3m1cA:
undetectable		 1g5yB-3m1cA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3net HISTIDYL-TRNA
SYNTHETASE

(Nostoc sp. PCC
7120) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 399
ALA A 369
GLN A 370
LEU A 461
PHE A 421
 None
 1.21A 1g5yB-3netA:
undetectable		 1g5yB-3netA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyb POLY(A) RNA
POLYMERASE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		5 ILE A 183
GLN A 327
LEU A 232
ALA A 331
ILE A 324
 None
 1.11A 1g5yB-3nybA:
2.7		 1g5yB-3nybA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		5 ILE A 367
ALA A 199
LEU A 200
LEU A 226
LEU A 208
 None
 1.19A 1g5yB-3oz7A:
undetectable		 1g5yB-3oz7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		5 LEU A  53
ARG A  27
ALA A  24
LEU A   9
ILE A 185
 None
 1.03A 1g5yB-3qfoA:
undetectable		 1g5yB-3qfoA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvn MANGANESE-CONTAINING
SUPEROXIDE DISMUTASE

(Candida
albicans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ILE A 137
ALA A 200
LEU A  87
ALA A  88
ILE A 167
 None
 1.23A 1g5yB-3qvnA:
undetectable		 1g5yB-3qvnA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00092
(VWA) 		5 ILE A 215
ALA A 219
LEU A 223
LEU A 134
ILE A  10
 None
 0.77A 1g5yB-3ragA:
undetectable		 1g5yB-3ragA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		5 LEU A 281
LEU A 133
LEU A 293
ALA A 290
LEU A  45
 None
 1.10A 1g5yB-3rpwA:
undetectable		 1g5yB-3rpwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 ILE B  63
LEU B  19
LEU B   8
PHE B  68
LEU B  69
 None
 1.05A 1g5yB-3t5vB:
undetectable		 1g5yB-3t5vB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		5 ALA A  62
LEU A 242
ALA A 241
PHE A  58
LEU A  57
 None
 1.23A 1g5yB-3tg9A:
undetectable		 1g5yB-3tg9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3y THREE PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 5 ILE B 106
LEU B  69
LEU B 147
PHE B 111
LEU B 112
 None
 1.13A 1g5yB-3u3yB:
undetectable		 1g5yB-3u3yB:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 5 LEU A 325
LEU A 317
ALA A 314
LEU A 296
ILE A 339
 None
 1.28A 1g5yB-4bpsA:
undetectable		 1g5yB-4bpsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		5 ILE A 101
ALA A 352
LEU A 135
LEU A 107
ILE A 104
 None
 1.23A 1g5yB-4djiA:
2.5		 1g5yB-4djiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 ILE A 243
ALA A 198
TRP A 233
LEU A 184
PHE A 196
 None
 1.24A 1g5yB-4ee9A:
undetectable		 1g5yB-4ee9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		5 ILE A 327
ALA A 348
LEU A 321
PHE A 324
ILE A 337
 None
ANP  A1001 (-3.6A)
None
None
None
 1.19A 1g5yB-4fieA:
undetectable		 1g5yB-4fieA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3a CLIP-ASSOCIATING
PROTEIN

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 ILE A 129
LEU A 192
LEU A 176
ALA A 175
LEU A 149
 None
 1.19A 1g5yB-4g3aA:
undetectable		 1g5yB-4g3aA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6n UBIQUITIN
CARBOXYL-HYDROLASE

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		5 ILE A 222
ALA A 220
LEU A 218
LEU A  90
ALA A  89
 None
 1.24A 1g5yB-4i6nA:
undetectable		 1g5yB-4i6nA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig7 UBIQUITIN C-TERMINAL
HYDROLASE 37

(Trichinella
spiralis) 		PF01088
(Peptidase_C12) 		5 ILE A 222
ALA A 220
LEU A 218
LEU A  90
ALA A  89
 None
 1.26A 1g5yB-4ig7A:
undetectable		 1g5yB-4ig7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		5 ALA A 468
LEU A 243
ALA A 239
PHE A 487
ILE A 465
 None
 1.23A 1g5yB-4iggA:
undetectable		 1g5yB-4iggA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4w ESPG3

(Mycolicibacterium
smegmatis) 		PF14011
(ESX-1_EspG) 		5 ILE A  31
ALA A  13
GLN A  12
LEU A  16
LEU A 114
 None
 1.29A 1g5yB-4l4wA:
undetectable		 1g5yB-4l4wA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 ILE A 204
LEU A 253
LEU A 281
PHE A 209
ILE A 205
 None
 1.20A 1g5yB-4lfeA:
3.2		 1g5yB-4lfeA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx1 UNCONVENTIONAL
MYOSIN-VA

(Homo sapiens) 		PF01843
(DIL) 		5 ALA A1775
LEU A1815
LEU A1751
ALA A1748
LEU A1781
 None
 0.96A 1g5yB-4lx1A:
undetectable		 1g5yB-4lx1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE

(Planctopirus
limnophila) 		PF01048
(PNP_UDP_1) 		5 ILE A 273
LEU A 176
LEU A 262
ALA A 263
ILE A 269
 None
 1.25A 1g5yB-4m1eA:
undetectable		 1g5yB-4m1eA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 ALA A 760
LEU A 763
LEU A 748
LEU A 731
ILE A 756
 None
 1.21A 1g5yB-4nc6A:
undetectable		 1g5yB-4nc6A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgw UNCHARACTERIZED
PROTEIN YETJ

(Bacillus
subtilis) 		PF01027
(Bax1-I) 		5 ILE A 185
LEU A 172
PHE A  20
LEU A  17
ILE A  16
 None
 0.98A 1g5yB-4pgwA:
undetectable		 1g5yB-4pgwA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		5 ALA A  56
LEU A  60
PHE A  67
LEU A  37
ILE A  38
 None
 0.99A 1g5yB-4q3kA:
undetectable		 1g5yB-4q3kA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2575
LEU A2569
LEU A2902
ALA A2899
LEU A2562
 None
 1.26A 1g5yB-4qyrA:
undetectable		 1g5yB-4qyrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		5 ALA A 254
LEU A 251
LEU A 241
LEU A 291
LEU A 260
 None
 0.99A 1g5yB-4r8lA:
undetectable		 1g5yB-4r8lA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwy ANTIBODY 8ANC131
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ILE H  37
ALA H  93
LEU H   4
LEU H  97
LEU H  50
 None
 1.29A 1g5yB-4rwyH:
undetectable		 1g5yB-4rwyH:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		5 ILE A 639
ALA A 329
LEU A 303
ALA A 680
ILE A 635
 None
 1.30A 1g5yB-4ufcA:
undetectable		 1g5yB-4ufcA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 213
ALA A 231
LEU A  40
ALA A 151
ILE A 240
 None
 1.28A 1g5yB-4xeuA:
undetectable		 1g5yB-4xeuA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 ILE A  90
ALA A  13
PHE A  33
LEU A  36
ILE A  37
 None
 1.09A 1g5yB-4xguA:
undetectable		 1g5yB-4xguA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynq THREE-PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 5 ILE A 106
LEU A  69
LEU A 147
PHE A 111
LEU A 112
 None
 1.17A 1g5yB-4ynqA:
undetectable		 1g5yB-4ynqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		5 ILE A 581
LEU A 623
LEU A 566
ALA A 589
LEU A 578
 None
 1.10A 1g5yB-4zcfA:
undetectable		 1g5yB-4zcfA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		5 ALA A  45
LEU A 314
LEU A 325
ALA A  37
ILE A  53
 None
 1.22A 1g5yB-4zk3A:
undetectable		 1g5yB-4zk3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 ILE A 186
ALA A 189
LEU A 208
ALA A 207
ILE A 190
 None
 1.28A 1g5yB-5bshA:
undetectable		 1g5yB-5bshA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 5 ALA B 587
LEU B  12
ARG B  46
LEU B 562
ALA B 563
 None
 1.22A 1g5yB-5cwwB:
undetectable		 1g5yB-5cwwB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 ILE A  47
LEU A 100
LEU A  61
ALA A  58
LEU A  65
 None
 1.22A 1g5yB-5esoA:
undetectable		 1g5yB-5esoA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 5 ILE A 193
LEU A  71
ALA A  40
LEU A 190
ILE A 192
 None
 1.00A 1g5yB-5jkqA:
undetectable		 1g5yB-5jkqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Sinorhizobium
meliloti) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 ILE A 255
ALA A 269
LEU A 266
LEU A 139
ALA A 155
 SAM  A 304 (-3.9A)
SAM  A 304 (-3.6A)
SO4  A 303 (-4.4A)
None
None
 1.24A 1g5yB-5l0zA:
undetectable		 1g5yB-5l0zA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp7 RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Mycolicibacterium
smegmatis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 ILE A  93
ALA A  95
LEU A  97
LEU A  75
ILE A  82
 None
 1.29A 1g5yB-5mp7A:
undetectable		 1g5yB-5mp7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 ILE A 367
ALA A 415
LEU A 422
LEU A 377
ILE A 371
 None
 1.24A 1g5yB-5ohjA:
undetectable		 1g5yB-5ohjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiv BIFUNCTIONAL
THYMIDYLATE/URIDYLAT
E KINASE

(Candida
albicans) 		PF02223
(Thymidylate_kin) 		5 ILE A  89
GLN A   5
LEU A  82
LEU A 139
ILE A   7
 None
 1.28A 1g5yB-5uivA:
undetectable		 1g5yB-5uivA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 ALA A 297
ALA A  51
PHE A 227
LEU A 195
ILE A 223
 None
 1.29A 1g5yB-5xn6A:
2.1		 1g5yB-5xn6A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 5 ILE A  13
LEU A  55
LEU A  95
LEU A  19
ILE A 184
 None
 0.89A 1g5yB-5yvsA:
undetectable		 1g5yB-5yvsA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 ALA A 498
LEU A 187
ALA A 371
LEU A 163
ILE A 368
 None
 1.23A 1g5yB-6c01A:
undetectable		 1g5yB-6c01A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus) 		no annotation 5 ILE G  40
LEU E  10
LEU G  20
ALA G  19
ILE G  36
 None
 1.25A 1g5yB-6cfwG:
undetectable		 1g5yB-6cfwG:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 5 ILE H   7
LEU F  82
ALA F  85
LEU H  12
ILE H   8
 None
 1.30A 1g5yB-6cfwH:
2.3		 1g5yB-6cfwH:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dip NOCTURNIN

(Homo sapiens) 		no annotation 5 ILE A 320
LEU A 247
ALA A 251
PHE A 240
ILE A 282
 None
 1.07A 1g5yB-6dipA:
undetectable		 1g5yB-6dipA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))

(Escherichia
coli) 		no annotation 5 ILE A 181
ALA A 158
TRP A 302
LEU A 192
ILE A 185
 None
 1.25A 1g5yB-6dkhA:
undetectable		 1g5yB-6dkhA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 5 ILE A 448
ALA A 420
LEU A 399
LEU A 430
ILE A 417
 None
 1.23A 1g5yB-6fa5A:
undetectable		 1g5yB-6fa5A:
14.77