SIMILAR PATTERNS OF AMINO ACIDS FOR 1FSL_B_NIOB145_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		4 PHE A 212
PHE A 312
LEU A 256
VAL A 307
 None
 0.90A 1fslB-1by7A:
undetectable		 1fslB-1by7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dly HEMOGLOBIN

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 PHE A  19
TYR A  20
ILE A  23
VAL A  83
 None
CYN  A 122 (-4.3A)
None
HEM  A 144 (-4.3A)
 0.58A 1fslB-1dlyA:
8.6		 1fslB-1dlyA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A 387
ILE A 372
LEU A 360
VAL A 343
 None
 0.88A 1fslB-1ethA:
undetectable		 1fslB-1ethA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 PHE A  70
ILE A  73
PHE A 142
LEU A 109
 None
 0.82A 1fslB-1g55A:
undetectable		 1fslB-1g55A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		4 PHE A 224
ILE A 151
LEU A 228
VAL A 180
 None
KCX  A 150 ( 4.0A)
None
None
 0.80A 1fslB-1gkpA:
undetectable		 1fslB-1gkpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmm CBM6

(Ruminiclostridium
thermocellum) 		PF03422
(CBM_6) 		4 PHE A 126
ILE A 102
HIS A 109
LEU A 111
 None
 0.85A 1fslB-1gmmA:
undetectable		 1fslB-1gmmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE B 386
ILE B 371
LEU B 359
VAL B 342
 None
 0.89A 1fslB-1lpbB:
undetectable		 1fslB-1lpbB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 PHE A 594
ILE A 589
HIS A 290
LEU A 294
 None
 0.90A 1fslB-1n21A:
1.4		 1fslB-1n21A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh3 DNA TOPOISOMERASE I

(Homo sapiens) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc) 		4 PHE A 527
ILE A 512
PHE A 565
VAL A 525
 None
 0.87A 1fslB-1nh3A:
0.0		 1fslB-1nh3A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 PHE A 138
ILE A 117
PHE A  67
PHE A 183
 None
OAD  A1001 ( 4.4A)
OAD  A1001 ( 4.6A)
None
 0.73A 1fslB-1q1aA:
undetectable		 1fslB-1q1aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR

(Caenorhabditis
elegans) 		PF09287
(CEP1-DNA_bind) 		4 PHE A 355
ILE A 325
PHE A 323
PHE A 359
 None
 0.79A 1fslB-1t4wA:
undetectable		 1fslB-1t4wA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A 365
HIS A 345
LEU A 383
VAL A 324
 None
 0.82A 1fslB-1u08A:
0.0		 1fslB-1u08A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unp RAC-ALPHA
SERINE/THREONINE
KINASE

(Homo sapiens) 		PF00169
(PH) 		4 PHE A  73
ILE A 103
PHE A  55
LEU A  12
 None
 0.88A 1fslB-1unpA:
undetectable		 1fslB-1unpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 PHE A  19
TYR A  20
ILE A  23
VAL A  83
 XE  A1126 ( 4.2A)
CYN  A1123 (-4.9A)
None
HEM  A1122 (-4.5A)
 0.72A 1fslB-1uvxA:
8.5		 1fslB-1uvxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		4 PHE A  19
TYR A  20
ILE A  23
VAL A  81
 None
None
None
HEM  A1117 (-4.4A)
 0.52A 1fslB-1uvyA:
8.0		 1fslB-1uvyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 ILE A 356
HIS A 400
LEU A 419
VAL A 354
 None
 0.87A 1fslB-1xzwA:
undetectable		 1fslB-1xzwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 PHE X 561
TYR X 532
ILE X 562
VAL X 510
 None
 0.70A 1fslB-1z3iX:
undetectable		 1fslB-1z3iX:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 443
PHE A 524
LEU A 400
VAL A 389
 None
 0.90A 1fslB-2ag1A:
undetectable		 1fslB-2ag1A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 PHE A 420
ILE A 422
LEU A 415
VAL A 376
 None
 0.76A 1fslB-2b9bA:
undetectable		 1fslB-2b9bA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N) 		4 PHE A 347
ILE A 337
PHE A 385
VAL A 345
 None
 0.90A 1fslB-2b9sA:
undetectable		 1fslB-2b9sA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A  93
TYR A 229
HIS A 202
VAL A 126
 None
None
FAD  A1524 (-3.5A)
None
 0.73A 1fslB-2c3dA:
undetectable		 1fslB-2c3dA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Homo sapiens) 		PF01869
(BcrAD_BadFG) 		4 PHE A 216
ILE A 220
HIS A 161
VAL A 184
 None
 0.82A 1fslB-2ch6A:
undetectable		 1fslB-2ch6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2emq HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00571
(CBS) 		4 PHE A 128
ILE A 109
LEU A 102
VAL A 133
 None
 0.87A 1fslB-2emqA:
undetectable		 1fslB-2emqA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gdm LEGHEMOGLOBIN (OXY)

(Lupinus luteus) 		PF00042
(Globin) 		4 PHE A  29
PHE A  44
PHE A  46
VAL A 110
 None
HEM  A 154 (-4.2A)
HEM  A 154 ( 4.9A)
HEM  A 154 (-4.4A)
 0.58A 1fslB-2gdmA:
22.4		 1fslB-2gdmA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knq GENERAL SECRETION
PATHWAY PROTEIN H

(Escherichia
coli) 		PF12019
(GspH) 		4 ILE A  40
PHE A  20
LEU A  84
VAL A  97
 None
 0.84A 1fslB-2knqA:
undetectable		 1fslB-2knqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mkk CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF16367
(RRM_7) 		4 PHE A 256
PHE A 286
LEU A 296
VAL A 328
 None
 0.90A 1fslB-2mkkA:
undetectable		 1fslB-2mkkA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		4 PHE A 270
ILE A 263
LEU A 281
VAL A 293
 None
 0.70A 1fslB-2ok8A:
undetectable		 1fslB-2ok8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		4 PHE A 112
TYR A 119
ILE A 106
VAL A  59
 None
 0.86A 1fslB-2q74A:
undetectable		 1fslB-2q74A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		4 ILE A  33
HIS A  55
LEU A  59
VAL A 308
 None
 0.90A 1fslB-2qzuA:
undetectable		 1fslB-2qzuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 PHE A 193
TYR A 195
ILE A 204
PHE A 374
 None
None
GOL  A1396 ( 4.4A)
None
 0.89A 1fslB-2vouA:
undetectable		 1fslB-2vouA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 PHE A 209
ILE A 252
PHE A 158
LEU A 240
 None
 0.71A 1fslB-2ww2A:
undetectable		 1fslB-2ww2A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		4 ILE A 228
PHE A  44
LEU A 433
VAL A 244
 None
 0.78A 1fslB-2yjnA:
undetectable		 1fslB-2yjnA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0r SENSOR PROTEIN

(Thermotoga
maritima) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 PHE A 635
PHE A 633
LEU A 655
VAL A 685
 None
 0.88A 1fslB-3a0rA:
1.5		 1fslB-3a0rA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		4 PHE A 236
ILE A 351
PHE A 265
LEU A 240
 None
 0.66A 1fslB-3aqkA:
1.7		 1fslB-3aqkA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		4 PHE A 905
ILE A 885
LEU A 870
VAL A 881
 None
 0.81A 1fslB-3bsxA:
undetectable		 1fslB-3bsxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 ILE A  95
PHE A 118
HIS A 193
VAL A  93
 None
 0.85A 1fslB-3clwA:
undetectable		 1fslB-3clwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		4 ILE A  96
HIS A 209
LEU A 208
VAL A  98
 None
 0.87A 1fslB-3dt8A:
undetectable		 1fslB-3dt8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ea0 ATPASE, PARA FAMILY

(Chlorobaculum
tepidum) 		PF13614
(AAA_31) 		4 PHE A 123
ILE A  39
LEU A 138
VAL A 121
 None
 0.88A 1fslB-3ea0A:
undetectable		 1fslB-3ea0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebt UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Burkholderia
pseudomallei) 		PF12680
(SnoaL_2) 		4 ILE A  65
PHE A  57
HIS A  35
VAL A  90
 None
None
UNL  A 133 (-4.0A)
None
 0.85A 1fslB-3ebtA:
undetectable		 1fslB-3ebtA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 PHE A 264
ILE A 241
LEU A 230
VAL A 169
 None
None
None
BFD  A 170 ( 3.0A)
 0.90A 1fslB-3ef1A:
undetectable		 1fslB-3ef1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli) 		PF02665
(Nitrate_red_gam) 		4 PHE C 182
PHE C   8
PHE C   9
LEU C 186
 None
 0.81A 1fslB-3egwC:
undetectable		 1fslB-3egwC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		4 ILE A 250
PHE A 333
LEU A 295
VAL A 257
 None
 0.77A 1fslB-3fgbA:
undetectable		 1fslB-3fgbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 ILE A 217
PHE A 113
HIS A  71
LEU A  70
 None
 0.74A 1fslB-3fw6A:
undetectable		 1fslB-3fw6A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz7 UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF01206
(TusA) 		4 TYR A  54
ILE A  70
LEU A  25
VAL A  32
 None
 0.68A 1fslB-3hz7A:
undetectable		 1fslB-3hz7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0u PHOSPHOTHREONINE
LYASE OSPF

(Shigella
flexneri) 		PF03536
(VRP3) 		4 ILE A 130
PHE A  51
LEU A 170
VAL A 157
 None
 0.71A 1fslB-3i0uA:
undetectable		 1fslB-3i0uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klu UNCHARACTERIZED
PROTEIN YQBN

(Bacillus
subtilis) 		PF08890
(Phage_TAC_5) 		4 PHE A  81
TYR A  82
ILE A  85
PHE A 136
 None
 0.74A 1fslB-3kluA:
undetectable		 1fslB-3kluA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4c DEDICATOR OF
CYTOKINESIS PROTEIN
1

(Homo sapiens) 		PF14429
(DOCK-C2) 		4 ILE A 499
HIS A 508
LEU A 509
VAL A 497
 None
 0.75A 1fslB-3l4cA:
undetectable		 1fslB-3l4cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		4 PHE A 352
ILE A  79
LEU A  66
VAL A  75
 None
 0.83A 1fslB-3pg1A:
undetectable		 1fslB-3pg1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		4 ILE A 251
PHE A 334
LEU A 296
VAL A 258
 None
 0.82A 1fslB-3scyA:
undetectable		 1fslB-3scyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 PHE B 214
ILE B 166
HIS B 257
LEU B 176
 None
 0.80A 1fslB-3u0jB:
undetectable		 1fslB-3u0jB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni) 		PF00406
(ADK) 		4 PHE A  13
TYR A  96
ILE A  93
VAL A  11
 None
 0.90A 1fslB-3umfA:
undetectable		 1fslB-3umfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 329
ILE A 328
PHE A 303
LEU A 338
 None
 0.79A 1fslB-3wpeA:
undetectable		 1fslB-3wpeA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x37 MITOCHONDRIAL
MORPHOGENESIS
PROTEIN SLD7

(Zygosaccharomyces
rouxii) 		no annotation 4 PHE B  77
TYR B  76
LEU B 105
VAL B  24
 None
 0.72A 1fslB-3x37B:
undetectable		 1fslB-3x37B:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuy TRANSPORTER

(Neisseria
meningitidis) 		PF01758
(SBF) 		4 PHE A 147
ILE A 103
LEU A 155
VAL A 100
 None
 0.85A 1fslB-3zuyA:
undetectable		 1fslB-3zuyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens) 		PF12790
(T6SS-SciN) 		4 ILE A 135
HIS A 161
LEU A  39
VAL A 121
 None
 0.79A 1fslB-4a1rA:
undetectable		 1fslB-4a1rA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 PHE C 763
ILE C 877
LEU C 856
VAL C 867
 None
 0.87A 1fslB-4aq1C:
undetectable		 1fslB-4aq1C:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 251
ILE A 230
PHE A 180
PHE A 293
 None
SR7  A1396 (-4.8A)
SR7  A1396 (-3.7A)
None
 0.75A 1fslB-4bn5A:
undetectable		 1fslB-4bn5A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 PHE A  93
ILE A  64
LEU A 179
VAL A  91
 None
 0.88A 1fslB-4f2aA:
undetectable		 1fslB-4f2aA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f98 HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF10976
(DUF2790) 		4 PHE A  78
TYR A  36
ILE A  76
VAL A  64
 GOL  A 101 (-4.2A)
GOL  A 101 (-4.7A)
None
None
 0.76A 1fslB-4f98A:
undetectable		 1fslB-4f98A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		4 PHE A 487
TYR A 491
ILE A 520
LEU A 537
 None
 0.84A 1fslB-4fgmA:
undetectable		 1fslB-4fgmA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		4 PHE A 514
PHE A 512
LEU A 378
VAL A 556
 None
 0.79A 1fslB-4gkpA:
undetectable		 1fslB-4gkpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glk ABIQ

(Lactococcus
lactis) 		PF13958
(ToxN_toxin) 		4 TYR A  12
ILE A  13
LEU A 158
VAL A  23
 None
 0.89A 1fslB-4glkA:
undetectable		 1fslB-4glkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		4 PHE A 364
TYR A 245
ILE A 329
PHE A 248
 None
 0.88A 1fslB-4gr4A:
undetectable		 1fslB-4gr4A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02463
(SMC_N)
no annotation 		4 PHE C 184
ILE C 207
LEU C 188
VAL A1153
 None
 0.88A 1fslB-4i99C:
undetectable		 1fslB-4i99C:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 366
ILE A 347
PHE A 297
PHE A 413
 None
 0.80A 1fslB-4ig9A:
undetectable		 1fslB-4ig9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		4 PHE A 122
ILE A 155
PHE A 152
LEU A 177
 None
 0.88A 1fslB-4mtkA:
undetectable		 1fslB-4mtkA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrj PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
uniformis) 		PF10282
(Lactonase) 		4 ILE A 237
PHE A 320
LEU A 282
VAL A 244
 None
 0.85A 1fslB-4qrjA:
undetectable		 1fslB-4qrjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		4 PHE A 182
PHE A 224
PHE A 216
LEU A 177
 None
 0.86A 1fslB-4r7bA:
undetectable		 1fslB-4r7bA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 PHE A 171
ILE A 148
LEU A 109
VAL A 152
 None
 0.91A 1fslB-4rjkA:
undetectable		 1fslB-4rjkA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1

(Saccharomyces
cerevisiae) 		PF04000
(Sas10_Utp3)
PF08066
(PMC2NT) 		4 PHE A  38
ILE B   7
LEU A  42
VAL A  28
 None
 0.86A 1fslB-4wfcA:
undetectable		 1fslB-4wfcA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 108
HIS A 504
LEU A 490
VAL A  94
 None
 0.82A 1fslB-4wjlA:
undetectable		 1fslB-4wjlA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		4 TYR A  62
ILE A  37
LEU A 281
VAL A 107
 None
 0.81A 1fslB-4x00A:
undetectable		 1fslB-4x00A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z85 2-NITROBENZOATE
NITROREDUCTASE

(Pseudomonas
fluorescens) 		PF01613
(Flavin_Reduct) 		4 TYR A  44
ILE A  59
LEU A  78
VAL A 156
 None
 0.80A 1fslB-4z85A:
undetectable		 1fslB-4z85A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 PHE A 366
ILE A 347
PHE A 297
PHE A 413
 None
 0.88A 1fslB-4zzhA:
undetectable		 1fslB-4zzhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 309
ILE A 285
PHE A 273
VAL A 130
 None
 0.78A 1fslB-4zzqA:
undetectable		 1fslB-4zzqA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		4 PHE A 143
ILE A 139
LEU A 161
VAL A 259
 None
 0.80A 1fslB-5fdnA:
1.7		 1fslB-5fdnA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 PHE A  66
ILE A  64
PHE A  33
HIS A  41
LEU A  42
 None
 1.24A 1fslB-5gw7A:
undetectable		 1fslB-5gw7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl8 TYPE II SECRETION
SYSTEM PROTEIN L

(Klebsiella
pneumoniae) 		PF12693
(GspL_C) 		4 PHE A 364
ILE A 328
PHE A 372
LEU A 351
 None
 0.88A 1fslB-5hl8A:
undetectable		 1fslB-5hl8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 PHE A 560
TYR A 531
ILE A 561
VAL A 509
 None
 0.68A 1fslB-5jxrA:
undetectable		 1fslB-5jxrA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxt CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		no annotation 4 PHE B 560
TYR B 531
ILE B 561
VAL B 509
 None
 0.69A 1fslB-5jxtB:
undetectable		 1fslB-5jxtB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks7 CARNITINE TRANSPORT
ATP-BINDING PROTEIN
OPUCA

(Listeria
monocytogenes) 		PF00571
(CBS) 		4 PHE A 320
TYR A 340
ILE A 343
VAL A 322
 None
 0.88A 1fslB-5ks7A:
undetectable		 1fslB-5ks7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 4 ILE A 104
PHE A 146
LEU A 133
VAL A  96
 None
 0.86A 1fslB-5m11A:
undetectable		 1fslB-5m11A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2

(Homo sapiens) 		no annotation 4 PHE A  92
ILE A  88
PHE A  86
LEU A  23
 8S9  A 302 (-4.5A)
None
None
None
 0.73A 1fslB-5mwaA:
undetectable		 1fslB-5mwaA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 ILE A1062
HIS A 712
LEU A 734
VAL A 863
 None
 0.85A 1fslB-5ngyA:
undetectable		 1fslB-5ngyA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A4125
PHE A4147
HIS A4054
VAL A4031
 None
 0.79A 1fslB-5nugA:
undetectable		 1fslB-5nugA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9e PUTATIVE U3 SMALL
NUCLEOLAR
RIBONUCLEOPROTEIN

(Chaetomium
thermophilum) 		PF04427
(Brix) 		4 PHE A 103
ILE A 107
HIS A 143
LEU A 167
 None
 0.69A 1fslB-5o9eA:
undetectable		 1fslB-5o9eA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 4 PHE A 372
ILE A 368
LEU A 388
VAL A 418
 None
 0.82A 1fslB-5oydA:
undetectable		 1fslB-5oydA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4m PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		4 ILE A 364
PHE A 340
LEU A 328
VAL A 332
 None
 0.90A 1fslB-5t4mA:
undetectable		 1fslB-5t4mA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN

(Cupriavidus
necator) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 TYR A  27
ILE A   5
LEU A 157
VAL A  62
 None
 0.77A 1fslB-5t57A:
undetectable		 1fslB-5t57A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 4 PHE A 281
TYR A 273
ILE A 266
LEU A 285
 None
 0.81A 1fslB-5txfA:
undetectable		 1fslB-5txfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Pyrococcus
furiosus) 		PF02463
(SMC_N)
no annotation 		4 PHE C 184
ILE C 207
LEU C 188
VAL A1153
 None
 0.86A 1fslB-5xnsC:
undetectable		 1fslB-5xnsC:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9w POLLEN RECEPTOR-LIKE
KINASE 6

(Arabidopsis
thaliana) 		no annotation 4 ILE B  76
PHE B  37
LEU B  48
VAL B  78
 None
 0.90A 1fslB-5y9wB:
undetectable		 1fslB-5y9wB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 4 ILE A 621
HIS A 500
LEU A 516
VAL A 535
 None
 0.81A 1fslB-5yjhA:
undetectable		 1fslB-5yjhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykh PUMILIO HOMOLOG 1

(Homo sapiens) 		no annotation 4 PHE A  78
ILE A  58
LEU A  43
VAL A  54
 None
 0.71A 1fslB-5ykhA:
undetectable		 1fslB-5ykhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 ILE A 190
PHE A 202
LEU A  75
VAL A  90
 None
 0.82A 1fslB-6begA:
undetectable		 1fslB-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccd ABC TRANSPORTER
ATP-BINDING/PERMEASE
PROTEIN RV1747

(Mycobacterium
tuberculosis) 		no annotation 4 ILE A  46
HIS A  90
LEU A  99
VAL A  41
 None
 0.88A 1fslB-6ccdA:
undetectable		 1fslB-6ccdA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE

(Proteus
mirabilis) 		no annotation 4 PHE A 253
TYR A 206
ILE A 231
LEU A 257
 None
 0.86A 1fslB-6cn0A:
undetectable		 1fslB-6cn0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv7 -

(-) 		no annotation 4 ILE A 364
PHE A 340
LEU A 328
VAL A 332
 None
 0.86A 1fslB-6cv7A:
undetectable		 1fslB-6cv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 ILE M 320
PHE M 343
PHE M 338
LEU M 551
 None
 0.84A 1fslB-6d6qM:
undetectable		 1fslB-6d6qM:
21.09