SIMILAR PATTERNS OF AMINO ACIDS FOR 1FSL_A_NIOA145

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		4 PHE A 212
PHE A 312
LEU A 256
VAL A 307
 None
 0.87A 1fslA-1by7A:
0.0		 1fslA-1by7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 PHE A 266
ILE A 259
HIS A 229
VAL A 255
 None
 0.91A 1fslA-1crkA:
0.0		 1fslA-1crkA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dly HEMOGLOBIN

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		5 PHE A  19
TYR A  20
ILE A  23
PHE A  33
VAL A  83
 None
CYN  A 122 (-4.3A)
None
HEM  A 144 ( 4.4A)
HEM  A 144 (-4.3A)
 0.94A 1fslA-1dlyA:
8.2		 1fslA-1dlyA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A 387
ILE A 372
LEU A 360
VAL A 343
 None
 0.87A 1fslA-1ethA:
undetectable		 1fslA-1ethA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 PHE A  70
ILE A  73
PHE A 142
LEU A 109
 None
 0.88A 1fslA-1g55A:
undetectable		 1fslA-1g55A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkp HYDANTOINASE

(Thermus sp.) 		PF01979
(Amidohydro_1) 		4 PHE A 224
ILE A 151
LEU A 228
VAL A 180
 None
KCX  A 150 ( 4.0A)
None
None
 0.84A 1fslA-1gkpA:
undetectable		 1fslA-1gkpA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 5 PHE Y 136
TYR Y 135
PHE Y 307
LEU Y 287
VAL Y 131
 None
GOL  Y 600 (-4.6A)
None
None
None
 1.40A 1fslA-1gllY:
1.7		 1fslA-1gllY:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmm CBM6

(Ruminiclostridium
thermocellum) 		PF03422
(CBM_6) 		4 PHE A 126
ILE A 102
HIS A 109
LEU A 111
 None
 0.86A 1fslA-1gmmA:
undetectable		 1fslA-1gmmA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gui LAMINARINASE 16A

(Thermotoga
maritima) 		PF02018
(CBM_4_9) 		4 TYR A 123
ILE A  79
LEU A  71
VAL A 154
 None
 0.88A 1fslA-1guiA:
undetectable		 1fslA-1guiA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 PHE A  28
TYR A  29
PHE A  43
VAL A  98
 None
None
HEM  A1398 (-3.9A)
HEM  A1398 (-4.5A)
 0.87A 1fslA-1gvhA:
12.8		 1fslA-1gvhA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyc LACCASE 2

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 198
ILE A 188
PHE A 211
LEU A 248
VAL A 190
 None
 1.24A 1fslA-1gycA:
undetectable		 1fslA-1gycA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 TYR A 442
ILE A 436
PHE A 446
PHE A 462
 None
 0.85A 1fslA-1h0hA:
0.0		 1fslA-1h0hA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 PHE A  33
TYR A  62
LEU A 209
VAL A 106
 None
 0.89A 1fslA-1imjA:
undetectable		 1fslA-1imjA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		4 PHE A 168
ILE A 150
LEU A 138
VAL A 125
 None
 0.89A 1fslA-1j6oA:
undetectable		 1fslA-1j6oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		4 PHE A 111
ILE A 110
PHE A 273
LEU A  57
 None
 0.91A 1fslA-1jikA:
undetectable		 1fslA-1jikA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Homo sapiens) 		PF01536
(SAM_decarbox) 		5 PHE A  18
ILE A 107
PHE A 141
LEU A  94
VAL A  16
 None
 1.25A 1fslA-1jl0A:
undetectable		 1fslA-1jl0A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 TYR A 380
ILE A 379
HIS A 449
LEU A 440
 None
 0.88A 1fslA-1k9aA:
undetectable		 1fslA-1k9aA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		5 PHE A  70
ILE A  34
PHE A   7
PHE A  11
HIS A  18
 None
None
DND  A 601 (-4.2A)
None
DND  A 601 (-4.0A)
 1.25A 1fslA-1kaqA:
undetectable		 1fslA-1kaqA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kya LACCASE

(Trametes
versicolor) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 198
ILE A 188
PHE A 211
LEU A 248
VAL A 190
 None
 1.24A 1fslA-1kyaA:
undetectable		 1fslA-1kyaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE B 386
ILE B 371
LEU B 359
VAL B 342
 None
 0.89A 1fslA-1lpbB:
undetectable		 1fslA-1lpbB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 PHE A 483
ILE A 484
PHE A 520
VAL A 487
 None
 0.88A 1fslA-1lw3A:
1.2		 1fslA-1lw3A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 PHE A 594
ILE A 589
HIS A 290
LEU A 294
 None
 0.85A 1fslA-1n21A:
undetectable		 1fslA-1n21A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh3 DNA TOPOISOMERASE I

(Homo sapiens) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc) 		4 PHE A 527
ILE A 512
PHE A 565
VAL A 525
 None
 0.89A 1fslA-1nh3A:
undetectable		 1fslA-1nh3A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		4 PHE A 404
ILE A 423
PHE A 357
VAL A 425
 None
 0.90A 1fslA-1ofmA:
undetectable		 1fslA-1ofmA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 PHE A 138
ILE A 117
PHE A  67
PHE A 183
 None
OAD  A1001 ( 4.4A)
OAD  A1001 ( 4.6A)
None
 0.69A 1fslA-1q1aA:
undetectable		 1fslA-1q1aA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ILE A 395
PHE A 386
LEU A 516
VAL A 484
 None
 0.82A 1fslA-1qhgA:
2.1		 1fslA-1qhgA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
no annotation 		4 ILE B 395
PHE B 386
LEU C 516
VAL C 484
 None
 0.84A 1fslA-1qhhB:
undetectable		 1fslA-1qhhB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 4 PHE A 324
TYR A 323
ILE A 320
LEU A 289
 None
 0.78A 1fslA-1qi9A:
undetectable		 1fslA-1qi9A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 133
TYR A 137
ILE A  29
PHE A 101
VAL A 131
 None
 1.32A 1fslA-1svdA:
undetectable		 1fslA-1svdA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4w C.ELEGANS P53 TUMOR
SUPPRESSOR-LIKE
TRANSCRIPTION FACTOR

(Caenorhabditis
elegans) 		PF09287
(CEP1-DNA_bind) 		4 PHE A 355
ILE A 325
PHE A 323
PHE A 359
 None
 0.86A 1fslA-1t4wA:
undetectable		 1fslA-1t4wA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A 365
HIS A 345
LEU A 383
VAL A 324
 None
 0.89A 1fslA-1u08A:
undetectable		 1fslA-1u08A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unp RAC-ALPHA
SERINE/THREONINE
KINASE

(Homo sapiens) 		PF00169
(PH) 		4 PHE A  73
ILE A 103
PHE A  55
LEU A  12
 None
 0.88A 1fslA-1unpA:
undetectable		 1fslA-1unpA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 PHE A  19
TYR A  20
ILE A  23
VAL A  83
 XE  A1126 ( 4.2A)
CYN  A1123 (-4.9A)
None
HEM  A1122 (-4.5A)
 0.80A 1fslA-1uvxA:
8.2		 1fslA-1uvxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		4 PHE A  19
TYR A  20
ILE A  23
VAL A  81
 None
None
None
HEM  A1117 (-4.4A)
 0.54A 1fslA-1uvyA:
7.9		 1fslA-1uvyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986

(Pyrococcus
horikoshii) 		PF03746
(LamB_YcsF) 		4 ILE A  87
HIS A 107
LEU A 141
VAL A 128
 None
 0.89A 1fslA-1v6tA:
undetectable		 1fslA-1v6tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ILE A 197
PHE A 218
LEU A 209
VAL A 470
 None
 0.90A 1fslA-1we5A:
undetectable		 1fslA-1we5A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wly 2-HALOACRYLATE
REDUCTASE

(Burkholderia
sp. WS) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A 219
ILE A 151
HIS A 141
LEU A 137
 TYR  A 219 ( 1.3A)
ILE  A 151 ( 0.7A)
HIS  A 141 ( 1.0A)
LEU  A 137 ( 0.6A)
 0.88A 1fslA-1wlyA:
undetectable		 1fslA-1wlyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		5 PHE A  88
ILE A  90
PHE A 141
LEU A 146
VAL A 158
 None
 1.38A 1fslA-1x9yA:
undetectable		 1fslA-1x9yA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 ILE A 356
HIS A 400
LEU A 419
VAL A 354
 None
 0.87A 1fslA-1xzwA:
undetectable		 1fslA-1xzwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF01717
(Meth_synt_2) 		4 PHE A 161
TYR A 154
ILE A 105
LEU A 165
 None
 0.90A 1fslA-1ypxA:
undetectable		 1fslA-1ypxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq6 MINOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF08949
(DUF1860) 		4 ILE A 332
PHE A 225
LEU A 327
VAL A 263
 None
 0.89A 1fslA-1yq6A:
undetectable		 1fslA-1yq6A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq8 MINOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF08949
(DUF1860) 		4 ILE A 332
PHE A 225
LEU A 327
VAL A 263
 None
 0.90A 1fslA-1yq8A:
undetectable		 1fslA-1yq8A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywq NITROREDUCTASE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 ILE A  67
HIS A  61
LEU A  56
VAL A 160
 None
 0.87A 1fslA-1ywqA:
undetectable		 1fslA-1ywqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 TYR A  85
PHE A  65
HIS A 112
LEU A 113
VAL A 134
 None
 1.23A 1fslA-1z0xA:
undetectable		 1fslA-1z0xA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 TYR A  85
PHE A  81
PHE A  65
HIS A 112
LEU A 113
 None
 1.46A 1fslA-1z0xA:
undetectable		 1fslA-1z0xA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE

(Danio rerio) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 PHE X 561
TYR X 532
ILE X 562
VAL X 510
 None
 0.71A 1fslA-1z3iX:
undetectable		 1fslA-1z3iX:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr4 TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		4 PHE A  83
ILE A  61
PHE A  92
LEU A  79
 None
 0.90A 1fslA-1zr4A:
undetectable		 1fslA-1zr4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 PHE A 483
ILE A 484
PHE A 520
VAL A 487
 None
 0.87A 1fslA-1zsqA:
undetectable		 1fslA-1zsqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01380
(SIS) 		4 PHE A  42
ILE A  37
PHE A  47
LEU A  70
 None
 0.91A 1fslA-2a3nA:
undetectable		 1fslA-2a3nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 443
PHE A 524
LEU A 400
VAL A 389
 None
 0.87A 1fslA-2ag1A:
undetectable		 1fslA-2ag1A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 PHE A 420
ILE A 422
LEU A 415
VAL A 376
 None
 0.79A 1fslA-2b9bA:
undetectable		 1fslA-2b9bA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N) 		4 PHE A 347
ILE A 337
PHE A 385
VAL A 345
 None
 0.91A 1fslA-2b9sA:
undetectable		 1fslA-2b9sA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A  93
TYR A 229
HIS A 202
VAL A 126
 None
None
FAD  A1524 (-3.5A)
None
 0.80A 1fslA-2c3dA:
undetectable		 1fslA-2c3dA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx6 HYPOTHETICAL PROTEIN
YHCO

(Escherichia
coli) 		PF01337
(Barstar) 		4 PHE A  73
ILE A  53
PHE A   6
PHE A   8
 None
 0.88A 1fslA-2cx6A:
undetectable		 1fslA-2cx6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e30 CALCIUM-BINDING
PROTEIN P22

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  70
ILE A  66
PHE A 117
LEU A  87
 None
 0.91A 1fslA-2e30A:
undetectable		 1fslA-2e30A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		4 PHE A 130
ILE A  58
PHE A 172
LEU A 126
 None
 0.81A 1fslA-2fnaA:
undetectable		 1fslA-2fnaA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd9 HYPOTHETICAL PROTEIN
YYAP

(Bacillus
subtilis) 		PF01872
(RibD_C) 		4 PHE A  88
ILE A 106
LEU A  51
VAL A 110
 None
 0.87A 1fslA-2gd9A:
undetectable		 1fslA-2gd9A:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gdm LEGHEMOGLOBIN (OXY)

(Lupinus luteus) 		PF00042
(Globin) 		4 PHE A  29
PHE A  44
PHE A  46
VAL A 110
 None
HEM  A 154 (-4.2A)
HEM  A 154 ( 4.9A)
HEM  A 154 (-4.4A)
 0.65A 1fslA-2gdmA:
22.6		 1fslA-2gdmA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		4 TYR A  32
ILE A   4
LEU A 253
VAL A  60
 None
 0.85A 1fslA-2ioyA:
undetectable		 1fslA-2ioyA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3d LIN0334 PROTEIN

(Listeria
innocua) 		PF07252
(DUF1433) 		4 PHE A  61
ILE A  53
PHE A  80
VAL A  35
 None
 0.91A 1fslA-2k3dA:
undetectable		 1fslA-2k3dA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knq GENERAL SECRETION
PATHWAY PROTEIN H

(Escherichia
coli) 		PF12019
(GspH) 		4 ILE A  40
PHE A  20
LEU A  84
VAL A  97
 None
 0.91A 1fslA-2knqA:
undetectable		 1fslA-2knqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		4 PHE A 254
TYR A 253
ILE A 250
VAL A 227
 None
 0.86A 1fslA-2obmA:
undetectable		 1fslA-2obmA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		5 PHE A 270
TYR A 214
ILE A 263
LEU A 281
VAL A 293
 None
 1.49A 1fslA-2ok8A:
undetectable		 1fslA-2ok8A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		4 ILE A  97
PHE A 125
LEU A  88
VAL A  72
 None
 0.88A 1fslA-2p4zA:
undetectable		 1fslA-2p4zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		4 PHE A 239
ILE A 219
HIS A 282
LEU A 283
 None
 0.89A 1fslA-2qmmA:
undetectable		 1fslA-2qmmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qu8 PUTATIVE NUCLEOLAR
GTP-BINDING PROTEIN
1

(Plasmodium
falciparum) 		PF06858
(NOG1) 		5 PHE A 133
ILE A 171
PHE A 181
PHE A 149
VAL A 175
 None
 1.44A 1fslA-2qu8A:
undetectable		 1fslA-2qu8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		4 ILE A  33
HIS A  55
LEU A  59
VAL A 308
 None
 0.88A 1fslA-2qzuA:
undetectable		 1fslA-2qzuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rm6 GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		4 PHE A  74
TYR A 119
LEU A  72
VAL A  20
 None
 0.91A 1fslA-2rm6A:
undetectable		 1fslA-2rm6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 PHE A 476
ILE A 578
PHE A 580
PHE A 457
VAL A 559
 None
 1.43A 1fslA-2vycA:
undetectable		 1fslA-2vycA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 PHE A 209
ILE A 252
PHE A 158
LEU A 240
 None
 0.76A 1fslA-2ww2A:
undetectable		 1fslA-2ww2A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 198
ILE A 188
PHE A 211
LEU A 248
VAL A 190
 None
 1.27A 1fslA-2xybA:
undetectable		 1fslA-2xybA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y38 LAMININ SUBUNIT
ALPHA-5

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		5 PHE A 193
ILE A 235
PHE A 268
LEU A 177
VAL A 237
 None
 1.45A 1fslA-2y38A:
undetectable		 1fslA-2y38A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		4 ILE A 228
PHE A  44
LEU A 433
VAL A 244
 None
 0.86A 1fslA-2yjnA:
undetectable		 1fslA-2yjnA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 PHE A 107
ILE A 105
LEU A 164
VAL A 117
 None
 0.86A 1fslA-2zi8A:
undetectable		 1fslA-2zi8A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 ILE A 551
PHE A 504
HIS A 538
LEU A 537
 None
 0.88A 1fslA-3a5iA:
undetectable		 1fslA-3a5iA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		4 PHE A 152
HIS A 172
LEU A 168
VAL A 187
 None
MN  A 271 ( 3.4A)
None
None
 0.88A 1fslA-3aamA:
undetectable		 1fslA-3aamA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 PHE A 547
ILE A 545
PHE A 534
VAL A 585
 None
 0.86A 1fslA-3af5A:
undetectable		 1fslA-3af5A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae) 		PF01513
(NAD_kinase) 		5 ILE A  72
PHE A 184
HIS A 187
LEU A  92
VAL A  70
 None
 1.41A 1fslA-3afoA:
undetectable		 1fslA-3afoA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqk POLY(A) POLYMERASE

(Escherichia
coli) 		PF01743
(PolyA_pol)
PF12626
(PolyA_pol_arg_C)
PF12627
(PolyA_pol_RNAbd) 		4 PHE A 236
ILE A 351
PHE A 265
LEU A 240
 None
 0.74A 1fslA-3aqkA:
1.5		 1fslA-3aqkA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		4 PHE X  92
ILE X  94
LEU X  51
VAL X  64
 None
 0.82A 1fslA-3brkX:
undetectable		 1fslA-3brkX:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		4 PHE A 905
ILE A 885
LEU A 870
VAL A 881
 None
 0.86A 1fslA-3bsxA:
undetectable		 1fslA-3bsxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8l FTSZ-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF09585
(Lin0512_fam) 		4 ILE A  55
PHE A  78
HIS A  49
VAL A 116
 IMD  A 125 ( 4.6A)
IMD  A 125 ( 4.6A)
None
None
 0.81A 1fslA-3c8lA:
undetectable		 1fslA-3c8lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 PHE A 109
ILE A 111
LEU A  98
VAL A  51
 None
 0.84A 1fslA-3cc1A:
undetectable		 1fslA-3cc1A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 PHE A 618
ILE A 620
LEU A 492
VAL A 514
 None
 0.82A 1fslA-3cf0A:
undetectable		 1fslA-3cf0A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		6 PHE A 150
ILE A  95
PHE A 118
PHE A 127
HIS A 193
VAL A  93
 None
 1.44A 1fslA-3clwA:
undetectable		 1fslA-3clwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		4 PHE A 108
ILE A  36
PHE A  34
PHE A  16
 None
 0.85A 1fslA-3cm5A:
undetectable		 1fslA-3cm5A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czq PUTATIVE
POLYPHOSPHATE KINASE
2

(Sinorhizobium
meliloti) 		PF03976
(PPK2) 		5 PHE A 191
PHE A 193
HIS A 269
LEU A 271
VAL A  74
 None
 1.22A 1fslA-3czqA:
undetectable		 1fslA-3czqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 380
ILE A 379
HIS A 449
LEU A 440
 None
 0.88A 1fslA-3d7uA:
undetectable		 1fslA-3d7uA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daf 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		5 PHE A 162
ILE A 166
PHE A 183
LEU A   6
VAL A 139
 None
None
None
FEG  A 501 (-4.1A)
None
 1.34A 1fslA-3dafA:
undetectable		 1fslA-3dafA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di4 UNCHARACTERIZED
PROTEIN DUF1989

(Ruegeria
pomeroyi) 		PF09347
(DUF1989) 		4 ILE A 125
PHE A  68
LEU A 194
VAL A 106
 None
 0.91A 1fslA-3di4A:
undetectable		 1fslA-3di4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		4 ILE A  96
HIS A 209
LEU A 208
VAL A  98
 None
 0.86A 1fslA-3dt8A:
undetectable		 1fslA-3dt8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e98 GAF DOMAIN OF
UNKNOWN FUNCTION

(Pseudomonas
aeruginosa) 		PF04340
(DUF484) 		5 PHE A 124
ILE A 122
PHE A 165
LEU A 148
VAL A 191
 None
 1.34A 1fslA-3e98A:
undetectable		 1fslA-3e98A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ea0 ATPASE, PARA FAMILY

(Chlorobaculum
tepidum) 		PF13614
(AAA_31) 		4 PHE A 123
ILE A  39
LEU A 138
VAL A 121
 None
 0.89A 1fslA-3ea0A:
undetectable		 1fslA-3ea0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A

(Homo sapiens) 		PF00620
(RhoGAP) 		4 PHE A  47
ILE A  46
LEU A 120
VAL A 102
 None
 0.86A 1fslA-3eapA:
undetectable		 1fslA-3eapA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebt UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Burkholderia
pseudomallei) 		PF12680
(SnoaL_2) 		4 ILE A  65
PHE A  57
HIS A  35
VAL A  90
 None
None
UNL  A 133 (-4.0A)
None
 0.86A 1fslA-3ebtA:
undetectable		 1fslA-3ebtA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli) 		PF02665
(Nitrate_red_gam) 		4 PHE C 182
PHE C   8
PHE C   9
LEU C 186
 None
 0.89A 1fslA-3egwC:
undetectable		 1fslA-3egwC:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 167
PHE A 176
LEU A 321
VAL A 208
 None
 0.90A 1fslA-3ezyA:
undetectable		 1fslA-3ezyA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		4 ILE A 250
PHE A 333
LEU A 295
VAL A 257
 None
 0.75A 1fslA-3fgbA:
undetectable		 1fslA-3fgbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		4 PHE A 112
ILE A 114
LEU A 232
VAL A 215
 None
 0.91A 1fslA-3fijA:
undetectable		 1fslA-3fijA:
20.24