SIMILAR PATTERNS OF AMINO ACIDS FOR 1FOH_C_IPHC802_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		5 GLY A 197
VAL A 200
ILE A 104
TYR A 143
GLY A 106
 None
 1.38A 1fohC-1aqlA:
0.0		 1fohC-1aqlA:
23.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.14A 1fohC-1fohA:
57.0		 1fohC-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.24A 1fohC-1fohA:
57.0		 1fohC-1fohA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 GLY A 203
VAL A 206
ILE A 115
TYR A 148
GLY A 117
 None
None
None
None
SAF  A1998 (-3.1A)
 1.37A 1fohC-1gqrA:
0.0		 1fohC-1gqrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ASP A  30
GLN A 122
ARG A 233
ILE A  29
GLY A  27
 None
 1.48A 1fohC-1gv3A:
undetectable		 1fohC-1gv3A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU) 		5 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.18A 1fohC-1hfeL:
0.0		 1fohC-1hfeL:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.38A 1fohC-1k4yA:
undetectable		 1fohC-1k4yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 345
VAL A 348
ARG A 277
ILE A 105
GLY A 343
 FAD  A3000 ( 4.6A)
None
None
None
None
 1.49A 1fohC-1m64A:
7.0		 1fohC-1m64A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY B 677
MET B 741
GLN B 678
VAL B 675
GLY B 681
 None
MCN  B4921 (-4.2A)
MCN  B4921 (-3.0A)
MCN  B4921 (-4.7A)
None
 1.44A 1fohC-1t3qB:
undetectable		 1fohC-1t3qB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 GLN A  99
VAL A  82
ILE A 116
TYR A 120
GLY A 132
 None
 1.21A 1fohC-1x0uA:
undetectable		 1fohC-1x0uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0v PUTATIVE PROTEASE LA
HOMOLOG TYPE

(Archaeoglobus
fulgidus) 		PF05362
(Lon_C) 		5 MET A 492
VAL A 449
ARG A 487
ILE A 522
GLY A 524
 None
 1.49A 1fohC-1z0vA:
undetectable		 1fohC-1z0vA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.44A 1fohC-2a3kA:
undetectable		 1fohC-2a3kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy9 THIOESTERASE
SUPERFAMILY MEMBER 2

(Mus musculus) 		PF03061
(4HBT) 		5 MET A  86
VAL A  64
ILE A  88
TYR A  90
GLY A  58
 None
 1.35A 1fohC-2cy9A:
undetectable		 1fohC-2cy9A:
10.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 ASP A  75
GLY A  76
ILE A 260
ARG A 269
TYR A 271
 3HB  A 641 (-2.8A)
3HB  A 641 (-3.3A)
3HB  A 641 (-4.2A)
FAD  A 640 (-3.8A)
3HB  A 641 ( 4.0A)
 0.28A 1fohC-2dkhA:
37.5		 1fohC-2dkhA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		5 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.10A 1fohC-2du7A:
undetectable		 1fohC-2du7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2

(Mus musculus) 		PF01007
(IRK) 		5 GLN A 230
VAL A 295
ARG A 228
ILE A 297
ARG A 312
 None
 1.39A 1fohC-2gixA:
undetectable		 1fohC-2gixA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.33A 1fohC-2h03A:
undetectable		 1fohC-2h03A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.16A 1fohC-2i5gA:
undetectable		 1fohC-2i5gA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 248
 None
 1.49A 1fohC-2i5gA:
undetectable		 1fohC-2i5gA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		5 GLY B 321
VAL B 322
ILE B 211
TYR B  59
GLY B 319
 None
 1.10A 1fohC-2odrB:
undetectable		 1fohC-2odrB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.05A 1fohC-2uutA:
undetectable		 1fohC-2uutA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		5 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.27A 1fohC-2w8iA:
undetectable		 1fohC-2w8iA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 GLY A 411
VAL A 412
ILE A 350
TYR A 354
GLY A 407
 None
 1.45A 1fohC-3ayfA:
0.9		 1fohC-3ayfA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1fohC-3b05A:
undetectable		 1fohC-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		5 GLY A 284
VAL A 287
ILE A 199
TYR A 230
GLY A 201
 None
 1.41A 1fohC-3biwA:
undetectable		 1fohC-3biwA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfu UNCHARACTERIZED
PROTEIN FROM
6-PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
FAMILY

(Corynebacterium
glutamicum) 		PF10727
(Rossmann-like) 		5 GLY A  55
MET A  82
VAL A  57
ILE A  48
GLY A  52
 None
 1.18A 1fohC-3dfuA:
undetectable		 1fohC-3dfuA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 ASP A  51
GLY A  52
GLN A 283
ARG A  53
GLY A  55
 None
 1.26A 1fohC-3g0iA:
undetectable		 1fohC-3g0iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 GLY S 499
GLN S 501
VAL S 500
ILE S 455
GLY S 518
 None
 1.09A 1fohC-3g9kS:
undetectable		 1fohC-3g9kS:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		5 GLY A 153
MET A 160
VAL A 154
ILE A 124
GLY A 151
 CL  A 600 ( 4.5A)
None
None
CL  A 600 (-4.2A)
None
 1.44A 1fohC-3griA:
undetectable		 1fohC-3griA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		5 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
 NAP  A 542 (-3.2A)
None
None
None
NAP  A 542 (-3.6A)
 0.96A 1fohC-3gwfA:
7.3		 1fohC-3gwfA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A1224
VAL A1227
ILE A1139
TYR A1170
GLY A1141
 None
None
None
None
WW2  A 193 (-3.8A)
 1.38A 1fohC-3k9bA:
undetectable		 1fohC-3k9bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.35A 1fohC-3kzvA:
undetectable		 1fohC-3kzvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 GLY A 233
VAL A 234
ILE A 215
TYR A   3
GLY A 231
 None
 1.22A 1fohC-3niwA:
undetectable		 1fohC-3niwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 ASP B 331
GLY B 330
VAL B 365
ARG B 368
GLY B 333
 None
 1.42A 1fohC-3ogkB:
undetectable		 1fohC-3ogkB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.32A 1fohC-3sopA:
undetectable		 1fohC-3sopA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 GLY A 357
VAL A 334
ARG A 396
ARG A  32
GLY A 398
 None
 1.44A 1fohC-3wfzA:
undetectable		 1fohC-3wfzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		5 ASP G  45
GLY G  46
VAL G 213
ILE G   4
GLY G   7
 None
 1.39A 1fohC-4adsG:
undetectable		 1fohC-4adsG:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		5 ASP A 269
GLY A 270
MET A 275
ARG A  52
GLY A 241
 None
None
None
FAD  A1493 (-4.9A)
FAD  A1493 (-3.6A)
 1.22A 1fohC-4at0A:
6.0		 1fohC-4at0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		5 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.96A 1fohC-4aweA:
undetectable		 1fohC-4aweA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		5 GLY A 236
VAL A 237
ILE A 193
ARG A 253
GLY A 197
 None
 0.95A 1fohC-4b2oA:
2.2		 1fohC-4b2oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 ASP A 118
GLY A  93
ARG A  88
ILE A 120
GLY A  91
 None
 1.10A 1fohC-4hesA:
undetectable		 1fohC-4hesA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 ASP B 163
GLY B 337
VAL B 336
ILE B 428
TYR B  13
 PO4  B 504 (-2.8A)
PO4  B 504 ( 3.8A)
None
None
None
 1.25A 1fohC-4i6mB:
undetectable		 1fohC-4i6mB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 GLY A 330
MET A 337
VAL A 333
ILE A 318
GLY A 121
 None
 1.12A 1fohC-4maaA:
undetectable		 1fohC-4maaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 ASP A 462
GLY A 469
GLN A 468
ARG A 445
ARG A 447
 None
 1.22A 1fohC-4nh0A:
undetectable		 1fohC-4nh0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xv0 BETA-XYLANASE

(Trichoderma
reesei) 		PF00331
(Glyco_hydro_10) 		5 GLY A 260
GLN A 295
VAL A 296
ILE A 285
GLY A 258
 None
 1.46A 1fohC-4xv0A:
undetectable		 1fohC-4xv0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2p SYNTENIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ASP A 158
GLY A 157
GLN A 141
VAL A 140
ARG A 155
 None
 1.44A 1fohC-5a2pA:
undetectable		 1fohC-5a2pA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.43A 1fohC-5b37A:
undetectable		 1fohC-5b37A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq7 FAB 5F-10-HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASP A 106
GLY A 104
ARG A  98
TYR A  32
GLY A 101
 None
 1.28A 1fohC-5bq7A:
undetectable		 1fohC-5bq7A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816
BD3460

(Bdellovibrio
bacteriovorus;
Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13)
PF12796
(Ank_2) 		5 ASP B 179
GLY B 175
GLN B 140
VAL B 171
GLY A 335
 None
 1.46A 1fohC-5cerB:
undetectable		 1fohC-5cerB:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		5 ASP A 173
GLY A 177
ILE A 172
ARG A 213
GLY A 212
 None
 1.49A 1fohC-5ernA:
undetectable		 1fohC-5ernA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 207
VAL A 210
ILE A 122
TYR A 153
GLY A 124
 None
 1.38A 1fohC-5fv4A:
undetectable		 1fohC-5fv4A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.26A 1fohC-5grhB:
undetectable		 1fohC-5grhB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		5 GLY A 514
GLN A 863
ILE A 498
TYR A 506
GLY A 509
 None
 1.47A 1fohC-5guhA:
undetectable		 1fohC-5guhA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		5 GLY A 339
GLN A 338
VAL A 362
ILE A 434
GLY A 316
 7BV  A 500 (-3.1A)
AMP  A 501 (-4.5A)
AMP  A 501 (-4.8A)
AMP  A 501 ( 4.5A)
7BV  A 500 (-3.1A)
 1.46A 1fohC-5gyzA:
undetectable		 1fohC-5gyzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 TRANSLATION
INITIATION FACTOR 1A

(Pyrococcus
abyssi) 		PF01176
(eIF-1a) 		5 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.33A 1fohC-5jb36:
undetectable		 1fohC-5jb36:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
 NAP  A 602 (-3.3A)
None
None
None
NAP  A 602 (-3.3A)
 0.91A 1fohC-5m10A:
5.1		 1fohC-5m10A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7
26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7)
PF01399
(PCI)
PF08375
(Rpn3_C) 		5 ASP R 365
ILE R 381
ARG R 383
TYR S 399
GLY R 369
 None
 0.98A 1fohC-5mpdR:
undetectable		 1fohC-5mpdR:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 191
VAL A 194
ILE A 106
TYR A 137
GLY A 108
 None
None
None
None
7BZ  A 601 ( 3.6A)
 1.36A 1fohC-5thmA:
undetectable		 1fohC-5thmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 GLY A 301
ILE A  46
ARG A 105
TYR A  44
GLY A 299
 None
None
PO4  A 401 (-3.2A)
None
None
 1.41A 1fohC-5tulA:
27.6		 1fohC-5tulA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 GLY C 124
MET C 233
VAL C 154
ILE C 126
GLY C 122
 None
 1.27A 1fohC-5xyiC:
undetectable		 1fohC-5xyiC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-) 		no annotation 5 GLY A  81
VAL A  89
ILE A 145
ARG A  82
GLY A  83
 None
 1.28A 1fohC-5y9pA:
undetectable		 1fohC-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 GLY A  64
GLN A 255
VAL A  48
ILE A  50
ARG A  51
 ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
None
None
None
 1.42A 1fohC-6ci7A:
undetectable		 1fohC-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 5 MET H  48
GLN H 162
VAL H 209
ARG H 133
ILE H 212
 None
 1.01A 1fohC-6df3H:
undetectable		 1fohC-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3


(;
) 		no annotation
no annotation 		5 MET H  48
VAL H 209
ARG H 133
ILE H 212
GLY C  63
 None
 1.15A 1fohC-6df3H:
undetectable		 1fohC-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 GLY A 267
VAL A 334
ARG A 321
TYR A 281
GLY A 263
 None
 1.45A 1fohC-6f5dA:
undetectable		 1fohC-6f5dA:
undetectable