SIMILAR PATTERNS OF AMINO ACIDS FOR 1FOH_B_IPHB802_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.00A 1fohB-1fohA:
68.1		 1fohB-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.23A 1fohB-1fohA:
68.1		 1fohB-1fohA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 GLY A 203
VAL A 206
ILE A 115
TYR A 148
GLY A 117
 None
None
None
None
SAF  A1998 (-3.1A)
 1.40A 1fohB-1gqrA:
0.0		 1fohB-1gqrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 GLY A 685
GLN A 684
VAL A 636
ILE A 604
GLY A 688
 None
 1.46A 1fohB-1h54A:
0.0		 1fohB-1h54A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU) 		5 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.21A 1fohB-1hfeL:
0.0		 1fohB-1hfeL:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		5 GLY A 247
VAL A  95
ILE A  76
TYR A 282
GLY A 234
 None
 1.18A 1fohB-1j32A:
0.0		 1fohB-1j32A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 GLY A 224
VAL A 227
ILE A 139
TYR A 170
GLY A 141
 None
 1.41A 1fohB-1k4yA:
0.0		 1fohB-1k4yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 345
VAL A 348
ARG A 277
ILE A 105
GLY A 343
 FAD  A3000 ( 4.6A)
None
None
None
None
 1.50A 1fohB-1m64A:
14.1		 1fohB-1m64A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)

(Homo sapiens;
Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
PF01749
(IBB) 		5 GLY A 771
MET B  47
GLN A 774
ARG B  50
GLY A 775
 None
 1.27A 1fohB-1qgrA:
0.0		 1fohB-1qgrA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY B 677
MET B 741
GLN B 678
VAL B 675
GLY B 681
 None
MCN  B4921 (-4.2A)
MCN  B4921 (-3.0A)
MCN  B4921 (-4.7A)
None
 1.45A 1fohB-1t3qB:
undetectable		 1fohB-1t3qB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 GLN A  99
VAL A  82
ILE A 116
TYR A 120
GLY A 132
 None
 1.19A 1fohB-1x0uA:
undetectable		 1fohB-1x0uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A 310
VAL A 317
ILE A 319
TYR A 340
GLY A 321
 None
 1.42A 1fohB-2a3kA:
undetectable		 1fohB-2a3kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		5 GLY A 400
GLN A 162
ILE A  46
ARG A 399
GLY A 398
 CYR  A 406 ( 4.9A)
None
None
None
None
 1.47A 1fohB-2aafA:
undetectable		 1fohB-2aafA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy9 THIOESTERASE
SUPERFAMILY MEMBER 2

(Mus musculus) 		PF03061
(4HBT) 		5 MET A  86
VAL A  64
ILE A  88
TYR A  90
GLY A  58
 None
 1.37A 1fohB-2cy9A:
undetectable		 1fohB-2cy9A:
10.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 ASP A  75
GLY A  76
ILE A 260
ARG A 269
TYR A 271
 3HB  A 641 (-2.8A)
3HB  A 641 (-3.3A)
3HB  A 641 (-4.2A)
FAD  A 640 (-3.8A)
3HB  A 641 ( 4.0A)
 0.29A 1fohB-2dkhA:
38.3		 1fohB-2dkhA:
36.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		5 GLY A 333
VAL A 334
ILE A 223
TYR A  70
GLY A 331
 None
 1.12A 1fohB-2du7A:
undetectable		 1fohB-2du7A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gix INWARD RECTIFIER
POTASSIUM CHANNEL 2

(Mus musculus) 		PF01007
(IRK) 		5 GLN A 230
VAL A 295
ARG A 228
ILE A 297
ARG A 312
 None
 1.40A 1fohB-2gixA:
undetectable		 1fohB-2gixA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 GLN A1923
VAL A1930
ILE A1932
TYR A1953
GLY A1934
 None
 1.32A 1fohB-2h03A:
undetectable		 1fohB-2h03A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLY A 246
VAL A 311
ILE A 233
TYR A 229
GLY A 210
 None
 1.17A 1fohB-2i5gA:
undetectable		 1fohB-2i5gA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		5 ASP A 260
GLY A 259
VAL A 255
ARG A 264
GLY A 262
 None
 1.48A 1fohB-2jk0A:
undetectable		 1fohB-2jk0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 ASP A 373
GLY A 369
GLN A 366
VAL A 370
GLY A 458
 None
 1.39A 1fohB-2nyfA:
undetectable		 1fohB-2nyfA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
megaterium;
Bacillus
megaterium) 		PF13377
(Peripla_BP_3)
PF00381
(PTS-HPr) 		5 GLY G 298
MET L  51
VAL G 300
ILE L  47
GLY G  81
 None
None
None
SEP  L  46 ( 4.2A)
None
 1.24A 1fohB-2nzuG:
undetectable		 1fohB-2nzuG:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		5 GLY B 321
VAL B 322
ILE B 211
TYR B  59
GLY B 319
 None
 1.12A 1fohB-2odrB:
undetectable		 1fohB-2odrB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus) 		PF02275
(CBAH) 		5 ASP A  69
GLY A  70
ARG A  17
TYR A 278
GLY A  56
 None
 1.17A 1fohB-2quyA:
undetectable		 1fohB-2quyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 ASP A  50
GLY A  47
GLN A  57
ARG A 181
GLY A  23
 None
 1.10A 1fohB-2uutA:
undetectable		 1fohB-2uutA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		5 ASP A  91
GLY A  90
VAL A 120
ILE A  87
TYR A  85
 None
 1.24A 1fohB-2w8iA:
undetectable		 1fohB-2w8iA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		5 ASP A 380
GLY A 379
ILE A 377
TYR A  61
GLY A 375
 None
 1.50A 1fohB-2zzrA:
undetectable		 1fohB-2zzrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.47A 1fohB-3b05A:
undetectable		 1fohB-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvg PUTATIVE METAL
BINDING PROTEIN

(Coccidioides
immitis) 		PF12849
(PBP_like_2) 		5 GLY A  48
VAL A  53
ILE A  97
TYR A  99
GLY A  45
 None
 1.17A 1fohB-3cvgA:
undetectable		 1fohB-3cvgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfu UNCHARACTERIZED
PROTEIN FROM
6-PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
FAMILY

(Corynebacterium
glutamicum) 		PF10727
(Rossmann-like) 		5 GLY A  55
MET A  82
VAL A  57
ILE A  48
GLY A  52
 None
 1.14A 1fohB-3dfuA:
undetectable		 1fohB-3dfuA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 ASP A  51
GLY A  52
GLN A 283
ARG A  53
GLY A  55
 None
 1.30A 1fohB-3g0iA:
undetectable		 1fohB-3g0iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		5 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
 NAP  A 542 (-3.2A)
None
None
None
NAP  A 542 (-3.6A)
 0.97A 1fohB-3gwfA:
7.6		 1fohB-3gwfA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 147
GLY A 377
MET A 305
GLN A 339
GLY A 379
 None
 1.42A 1fohB-3ijlA:
undetectable		 1fohB-3ijlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 GLY A   9
VAL A  34
ARG A  36
ILE A  59
GLY A  87
 GOL  A 255 (-3.3A)
None
None
None
GOL  A 255 ( 4.7A)
 1.36A 1fohB-3kzvA:
undetectable		 1fohB-3kzvA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 GLY A 233
VAL A 234
ILE A 215
TYR A   3
GLY A 231
 None
 1.24A 1fohB-3niwA:
undetectable		 1fohB-3niwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A
PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis;
Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3)
no annotation 		5 GLY A 299
MET S  51
VAL A 301
ILE S  47
GLY A  82
 None
None
None
SEP  S  46 ( 4.1A)
None
 1.21A 1fohB-3oqnA:
undetectable		 1fohB-3oqnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.31A 1fohB-3sopA:
undetectable		 1fohB-3sopA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		5 GLY A 192
VAL A 190
ILE A 201
TYR A 344
GLY A 194
 NAP  A 552 (-3.4A)
None
None
None
NAP  A 552 (-3.4A)
 0.93A 1fohB-3up4A:
7.1		 1fohB-3up4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 GLY A 357
VAL A 334
ARG A 396
ARG A  32
GLY A 398
 None
 1.40A 1fohB-3wfzA:
undetectable		 1fohB-3wfzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		5 GLY A 198
VAL A 196
ILE A 207
TYR A 349
GLY A 200
 None
None
None
None
NAP  A1553 (-3.5A)
 0.96A 1fohB-4ap3A:
8.5		 1fohB-4ap3A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		5 ASP A 269
GLY A 270
MET A 275
ARG A  52
GLY A 241
 None
None
None
FAD  A1493 (-4.9A)
FAD  A1493 (-3.6A)
 1.26A 1fohB-4at0A:
5.2		 1fohB-4at0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		5 MET A 342
VAL A 298
ARG A  55
ILE A 118
GLY A 227
 None
None
TRS  A1391 ( 4.9A)
None
None
 0.99A 1fohB-4aweA:
undetectable		 1fohB-4aweA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2o YMDB
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF13277
(YmdB) 		5 GLY A 236
VAL A 237
ILE A 193
ARG A 253
GLY A 197
 None
 0.99A 1fohB-4b2oA:
1.9		 1fohB-4b2oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ASP A 226
GLY A 241
VAL A 239
ILE A 229
GLY A 219
 None
 1.36A 1fohB-4h1sA:
undetectable		 1fohB-4h1sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		5 ASP A 118
GLY A  93
ARG A  88
ILE A 120
GLY A  91
 None
 1.13A 1fohB-4hesA:
undetectable		 1fohB-4hesA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 ASP B 163
GLY B 337
VAL B 336
ILE B 428
TYR B  13
 PO4  B 504 (-2.8A)
PO4  B 504 ( 3.8A)
None
None
None
 1.27A 1fohB-4i6mB:
undetectable		 1fohB-4i6mB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 GLY A 330
MET A 337
VAL A 333
ILE A 318
GLY A 121
 None
 1.09A 1fohB-4maaA:
undetectable		 1fohB-4maaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		5 ASP A 106
GLY A 531
VAL A 108
ARG A  52
GLY A 534
 None
PQQ  A 602 (-3.2A)
PQQ  A 602 (-4.8A)
None
None
 1.42A 1fohB-4maeA:
undetectable		 1fohB-4maeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 ASP A 462
GLY A 469
GLN A 468
ARG A 445
ARG A 447
 None
 1.20A 1fohB-4nh0A:
undetectable		 1fohB-4nh0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 112
MET A 295
VAL A 133
ILE A 110
GLY A  41
 None
 1.41A 1fohB-5b37A:
undetectable		 1fohB-5b37A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq7 FAB 5F-10-HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASP A 106
GLY A 104
ARG A  98
TYR A  32
GLY A 101
 None
 1.28A 1fohB-5bq7A:
undetectable		 1fohB-5bq7A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		5 ASP A 173
GLY A 177
ILE A 172
ARG A 213
GLY A 212
 None
 1.46A 1fohB-5ernA:
undetectable		 1fohB-5ernA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLY A 207
VAL A 210
ILE A 122
TYR A 153
GLY A 124
 None
 1.41A 1fohB-5fv4A:
undetectable		 1fohB-5fv4A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.22A 1fohB-5grhB:
undetectable		 1fohB-5grhB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 ASP A 226
GLY A 241
VAL A 239
ILE A 229
GLY A 219
 None
 1.37A 1fohB-5h7wA:
2.2		 1fohB-5h7wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 TRANSLATION
INITIATION FACTOR 1A

(Pyrococcus
abyssi) 		PF01176
(eIF-1a) 		5 ASP 6  65
GLY 6  64
MET 6  37
VAL 6  28
ILE 6  61
 None
None
A  21448 ( 4.0A)
None
A  21448 ( 3.4A)
 1.31A 1fohB-5jb36:
undetectable		 1fohB-5jb36:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
 NAP  A 602 (-3.3A)
None
None
None
NAP  A 602 (-3.3A)
 0.92A 1fohB-5m10A:
9.4		 1fohB-5m10A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7
26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7)
PF01399
(PCI)
PF08375
(Rpn3_C) 		5 ASP R 365
ILE R 381
ARG R 383
TYR S 399
GLY R 369
 None
 0.97A 1fohB-5mpdR:
undetectable		 1fohB-5mpdR:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwv L,D-TRANSPEPTIDASE 2

(Mycobacteroides
abscessus) 		no annotation 5 GLY B 369
GLN B 165
VAL B 161
ILE B 246
GLY B 164
 None
 1.38A 1fohB-5uwvB:
undetectable		 1fohB-5uwvB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 GLY C 124
MET C 233
VAL C 154
ILE C 126
GLY C 122
 None
 1.29A 1fohB-5xyiC:
undetectable		 1fohB-5xyiC:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-) 		no annotation 5 GLY A  81
VAL A  89
ILE A 145
ARG A  82
GLY A  83
 None
 1.24A 1fohB-5y9pA:
undetectable		 1fohB-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 GLY A 481
VAL A 483
ARG A 400
ILE A 463
GLY A 393
 None
 1.31A 1fohB-6at7A:
undetectable		 1fohB-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 GLY A  64
GLN A 255
VAL A  48
ILE A  50
ARG A  51
 ACP  A 500 ( 4.9A)
ACP  A 500 ( 4.9A)
None
None
None
 1.42A 1fohB-6ci7A:
undetectable		 1fohB-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 5 MET H  48
GLN H 162
VAL H 209
ARG H 133
ILE H 212
 None
 1.02A 1fohB-6df3H:
undetectable		 1fohB-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3


(;
) 		no annotation
no annotation 		5 MET H  48
VAL H 209
ARG H 133
ILE H 212
GLY C  63
 None
 1.13A 1fohB-6df3H:
undetectable		 1fohB-6df3H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 GLY A 267
VAL A 334
ARG A 321
TYR A 281
GLY A 263
 None
 1.44A 1fohB-6f5dA:
undetectable		 1fohB-6f5dA:
undetectable