SIMILAR PATTERNS OF AMINO ACIDS FOR 1FO4_B_SALB4005

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		4 SER A 187
ARG A 196
THR A  17
ALA A  14
 None
 1.07A 1fo4B-1a59A:
0.0		 1fo4B-1a59A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 GLU A 577
SER A 913
VAL A 893
ALA A  52
 None
None
ORN  A4010 ( 4.7A)
None
 1.06A 1fo4B-1c30A:
1.8		 1fo4B-1c30A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 SER A  84
THR A  33
VAL A  35
ALA A  26
 None
 1.05A 1fo4B-1c3xA:
undetectable		 1fo4B-1c3xA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		4 PHE A 127
THR A 116
VAL A 115
ALA A 123
 None
 0.98A 1fo4B-1c4xA:
0.0		 1fo4B-1c4xA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		5 GLU A 267
ARG A 152
THR A 198
VAL A 199
ALA A 216
 MN  A 500 (-2.8A)
None
None
None
MN  A 500 ( 4.5A)
 1.35A 1fo4B-1f1uA:
undetectable		 1fo4B-1f1uA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 GLU A 298
THR A 167
VAL A 166
ALA A 183
 None
 1.05A 1fo4B-1flcA:
undetectable		 1fo4B-1flcA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwp EBULIN

(Sambucus ebulus) 		PF00652
(Ricin_B_lectin) 		4 ARG B 181
THR B 132
VAL B  16
ALA B 127
 None
 1.05A 1fo4B-1hwpB:
undetectable		 1fo4B-1hwpB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 GLU A 303
PHE A 356
THR A 338
ALA A 299
 None
 1.09A 1fo4B-1jx2A:
0.0		 1fo4B-1jx2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 GLU A 332
THR A 259
VAL A 260
ALA A 253
 None
 1.07A 1fo4B-1kq3A:
0.0		 1fo4B-1kq3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 SER A 314
THR A 237
VAL A 239
ALA A 334
 None
 1.11A 1fo4B-1kvkA:
undetectable		 1fo4B-1kvkA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ARG A  79
THR A 247
VAL A 249
ALA A  61
 None
 1.07A 1fo4B-1m0uA:
undetectable		 1fo4B-1m0uA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 PHE A 166
THR A 199
VAL A 198
ALA A 205
 None
 0.87A 1fo4B-1m2wA:
undetectable		 1fo4B-1m2wA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 SER A3049
THR A3055
VAL A3021
ALA A3007
 None
 1.06A 1fo4B-1mjeA:
undetectable		 1fo4B-1mjeA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		7 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
ALA A1078
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
MOS  A3004 (-3.0A)
 0.27A 1fo4B-1n5xA:
46.5		 1fo4B-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 SER A 876
PHE A 914
VAL A1011
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
TEI  A3006 ( 3.8A)
 1.02A 1fo4B-1n5xA:
46.5		 1fo4B-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 ARG B 192
PHE B 191
THR B  54
ALA B 131
 PO4  B 902 (-4.2A)
None
None
None
 0.66A 1fo4B-1nzyB:
undetectable		 1fo4B-1nzyB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6b HARMONIN ISOFORM A1

(Mus musculus) 		PF00595
(PDZ) 		4 PHE A   9
THR A  77
VAL A  76
ALA A 104
 None
 1.05A 1fo4B-1v6bA:
undetectable		 1fo4B-1v6bA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ARG A 209
THR A 138
VAL A 124
ALA A 204
 None
 1.04A 1fo4B-1v9pA:
undetectable		 1fo4B-1v9pA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 GLU A  71
SER A  89
THR A  87
VAL A 104
ALA A  79
 GLU  A  71 ( 0.6A)
SER  A  89 ( 0.0A)
THR  A  87 ( 0.8A)
VAL  A 104 ( 0.6A)
ALA  A  79 ( 0.0A)
 1.23A 1fo4B-1wsvA:
undetectable		 1fo4B-1wsvA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		4 ARG A 513
THR A 399
VAL A 400
ALA A 394
 None
 0.93A 1fo4B-1x0uA:
undetectable		 1fo4B-1x0uA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ymm T CELL RECEPTOR
ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 SER D  72
THR D  64
VAL D  63
ALA D  19
 None
 0.89A 1fo4B-1ymmD:
undetectable		 1fo4B-1ymmD:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 PHE A 647
THR A 636
VAL A 635
ALA A 642
 None
 1.00A 1fo4B-2bucA:
undetectable		 1fo4B-2bucA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLU A 177
SER A 205
ARG A 217
VAL A 214
 None
 1.06A 1fo4B-2eidA:
undetectable		 1fo4B-2eidA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		4 ARG A 430
THR A 467
VAL A 466
ALA A 592
 None
 1.08A 1fo4B-2fy2A:
undetectable		 1fo4B-2fy2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0u NADPH-FLAVIN
OXIDOREDUCTASE

(Helicobacter
pylori) 		PF00881
(Nitroreductase) 		4 GLU A 185
SER A  93
VAL A  89
ALA A 184
 None
 1.08A 1fo4B-2h0uA:
undetectable		 1fo4B-2h0uA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjn MAINTENANCE OF
PLOIDY PROTEIN MOB1

(Saccharomyces
cerevisiae) 		PF03637
(Mob1_phocein) 		4 PHE A 283
THR A 134
VAL A 131
ALA A 260
 None
 1.08A 1fo4B-2hjnA:
undetectable		 1fo4B-2hjnA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijz PROBABLE M18-FAMILY
AMINOPEPTIDASE 2

(Pseudomonas
aeruginosa) 		PF02127
(Peptidase_M18) 		4 GLU A 246
THR A 390
VAL A 391
ALA A  81
 None
 1.09A 1fo4B-2ijzA:
undetectable		 1fo4B-2ijzA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 ARG A 148
THR A 211
VAL A 212
ALA A 204
 None
 0.79A 1fo4B-2j7cA:
undetectable		 1fo4B-2j7cA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxu TERB

(Klebsiella
pneumoniae) 		PF05099
(TerB) 		4 GLU A  65
PHE A  30
THR A  34
VAL A  35
 None
 0.91A 1fo4B-2jxuA:
undetectable		 1fo4B-2jxuA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzv CYSTATIN

(Sesamum indicum) 		PF16845
(SQAPI) 		4 SER A  12
ARG A  44
VAL A  40
ALA A  70
 None
 1.06A 1fo4B-2mzvA:
undetectable		 1fo4B-2mzvA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN

(Pectobacterium
carotovorum) 		PF06228
(ChuX_HutX) 		4 SER A 122
PHE A 154
VAL A 124
ALA A 158
 None
 1.09A 1fo4B-2ph0A:
undetectable		 1fo4B-2ph0A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLU A 154
SER A  69
THR A  67
VAL A  74
 None
 1.09A 1fo4B-2pt6A:
undetectable		 1fo4B-2pt6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 GLU A 329
SER A 365
PHE A 392
ALA A 395
 None
 1.00A 1fo4B-2q3zA:
1.7		 1fo4B-2q3zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		4 GLU A 228
THR A 109
VAL A 110
ALA A 211
 None
 0.89A 1fo4B-2q74A:
undetectable		 1fo4B-2q74A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qif COPPER CHAPERONE
COPZ

(Bacillus
subtilis) 		PF00403
(HMA) 		4 GLU A   9
THR A   5
VAL A  42
ALA A  68
 None
 1.10A 1fo4B-2qifA:
undetectable		 1fo4B-2qifA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1

(Homo sapiens) 		PF13238
(AAA_18) 		4 ARG A 129
PHE A 143
THR A  12
VAL A  11
 TIZ  A 302 ( 2.8A)
None
TIZ  A 302 ( 4.2A)
None
 1.01A 1fo4B-2ql6A:
undetectable		 1fo4B-2ql6A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 SER A 226
PHE A 416
VAL A 232
ALA A 411
 None
 1.03A 1fo4B-2qtzA:
undetectable		 1fo4B-2qtzA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		4 SER A  25
THR A 240
VAL A 238
ALA A  35
 None
 1.04A 1fo4B-2vwsA:
undetectable		 1fo4B-2vwsA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ARG B 310
PHE B 344
THR B 460
ALA B 528
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
 0.33A 1fo4B-2w55B:
35.1		 1fo4B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 SER A  47
ARG A  51
THR A  21
ALA A  53
 None
 1.04A 1fo4B-2x4gA:
undetectable		 1fo4B-2x4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 ARG A  30
PHE A  51
VAL A  25
ALA A  32
 None
 1.09A 1fo4B-2z3tA:
undetectable		 1fo4B-2z3tA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLU A  78
SER A  35
VAL A  93
ALA A 104
 None
None
NDP  A3001 (-4.1A)
None
 1.08A 1fo4B-3a14A:
undetectable		 1fo4B-3a14A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahr ERO1-LIKE PROTEIN
ALPHA

(Homo sapiens) 		PF04137
(ERO1) 		4 GLU A 311
ARG A 449
THR A 452
VAL A 454
 None
 1.08A 1fo4B-3ahrA:
undetectable		 1fo4B-3ahrA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 SER A 182
PHE A 165
THR A 153
VAL A 150
 None
 1.08A 1fo4B-3b1rA:
undetectable		 1fo4B-3b1rA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 SER A 154
THR A 119
VAL A 118
ALA A 178
 None
 1.01A 1fo4B-3cprA:
undetectable		 1fo4B-3cprA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  71
THR A  75
VAL A  76
ALA A  17
 None
 1.09A 1fo4B-3ddmA:
undetectable		 1fo4B-3ddmA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		4 GLU A 103
THR A  31
VAL A  32
ALA A  98
 None
 1.02A 1fo4B-3enqA:
undetectable		 1fo4B-3enqA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		4 ARG A 395
THR A 391
VAL A 390
ALA A 372
 None
 0.97A 1fo4B-3gueA:
undetectable		 1fo4B-3gueA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A  60
PHE A 295
VAL A  55
ALA A  62
 None
 1.06A 1fo4B-3hdxA:
undetectable		 1fo4B-3hdxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfs ANTHOCYANIDIN
REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		4 GLU A 311
THR A 192
VAL A 193
ALA A 259
 None
 1.05A 1fo4B-3hfsA:
0.8		 1fo4B-3hfsA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		4 ARG A  53
PHE A 105
VAL A  63
ALA A 108
 None
 1.08A 1fo4B-3hiwA:
undetectable		 1fo4B-3hiwA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 GLU A 268
ARG A 181
THR A  99
VAL A  73
 None
 1.07A 1fo4B-3hn2A:
undetectable		 1fo4B-3hn2A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 GLU A 170
SER A  21
PHE A 252
ALA A 248
 None
 0.97A 1fo4B-3iehA:
undetectable		 1fo4B-3iehA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itd 17BETA-HYDROXYSTEROI
D DEHYDROGENASE

(Curvularia
lunata) 		PF13561
(adh_short_C2) 		4 PHE A  87
THR A  24
VAL A  23
ALA A  90
 None
 1.09A 1fo4B-3itdA:
undetectable		 1fo4B-3itdA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k77 DNA REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF01834
(XRCC1_N) 		4 SER A 133
PHE A 142
VAL A 131
ALA A  35
 None
 1.06A 1fo4B-3k77A:
undetectable		 1fo4B-3k77A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 ARG X  95
THR X 274
VAL X 275
ALA X 267
 None
 0.93A 1fo4B-3n5nX:
undetectable		 1fo4B-3n5nX:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PHE A 108
THR A  18
VAL A  19
ALA A 308
 None
None
None
FAD  A 501 (-3.0A)
 0.94A 1fo4B-3nixA:
undetectable		 1fo4B-3nixA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 SER A  56
THR A  62
VAL A  61
ALA A  70
 None
 0.92A 1fo4B-3r5tA:
undetectable		 1fo4B-3r5tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		4 SER A 143
THR A 108
VAL A 107
ALA A 168
 None
 1.10A 1fo4B-3si9A:
undetectable		 1fo4B-3si9A:
13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		7 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1078
 RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
 0.24A 1fo4B-3sr6C:
41.7		 1fo4B-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 SER C 876
PHE C 914
VAL C1011
ALA C1079
 None
RMO  C1317 (-3.6A)
None
RMO  C1317 ( 3.6A)
 0.98A 1fo4B-3sr6C:
41.7		 1fo4B-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t04 MONOBODY 7C12

(Homo sapiens) 		PF00041
(fn3) 		4 ARG D  42
THR D  58
VAL D  59
ALA D  83
 None
 1.06A 1fo4B-3t04D:
undetectable		 1fo4B-3t04D:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 GLU B 580
THR B 661
VAL B 662
ALA B 583
 None
 0.75A 1fo4B-3thwB:
2.8		 1fo4B-3thwB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae) 		PF13561
(adh_short_C2) 		4 ARG A 109
THR A 113
VAL A 114
ALA A 155
 None
None
NAP  A 274 ( 4.7A)
None
 0.64A 1fo4B-3uf0A:
undetectable		 1fo4B-3uf0A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cql ESTRADIOL
17-BETA-DEHYDROGENAS
E 8

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 SER A 102
THR A 131
VAL A 134
ALA A 183
 None
 1.07A 1fo4B-4cqlA:
undetectable		 1fo4B-4cqlA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 SER A 285
THR A 317
VAL A 318
ALA A 314
 None
 0.97A 1fo4B-4dyjA:
undetectable		 1fo4B-4dyjA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		4 GLU A 320
ARG A 238
VAL A 200
ALA A 323
 None
 1.09A 1fo4B-4f3nA:
undetectable		 1fo4B-4f3nA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 ARG A 151
THR A 161
VAL A 162
ALA A 175
 None
 1.06A 1fo4B-4grsA:
undetectable		 1fo4B-4grsA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwr PROTEIN
DISULFIDE-ISOMERASE
A6

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 GLU A 164
THR A 223
VAL A 224
ALA A 219
 None
 0.87A 1fo4B-4gwrA:
undetectable		 1fo4B-4gwrA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLU A 118
THR A  73
VAL A  74
ALA A 116
 None
 1.06A 1fo4B-4j16A:
undetectable		 1fo4B-4j16A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 ARG A 181
THR A  83
VAL A  82
ALA A  90
 None
 0.91A 1fo4B-4jkzA:
undetectable		 1fo4B-4jkzA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq6 PROTEORHODOPSIN

(uncultured
bacterium) 		PF01036
(Bac_rhodopsin) 		4 PHE A  55
THR A  26
VAL A  27
ALA A  20
 None
 0.94A 1fo4B-4jq6A:
undetectable		 1fo4B-4jq6A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 SER A 615
THR A 751
VAL A 752
ALA A 608
 None
 1.08A 1fo4B-4kf7A:
2.6		 1fo4B-4kf7A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 GLU A 334
THR A 261
VAL A 262
ALA A 255
 None
 1.09A 1fo4B-4mcaA:
undetectable		 1fo4B-4mcaA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 SER B 155
PHE B 172
VAL B 176
ALA B 164
 None
 0.99A 1fo4B-4mrmB:
undetectable		 1fo4B-4mrmB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o93 NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA 2

(Thermus
thermophilus) 		PF12769
(PNTB_4TM) 		4 PHE A  40
THR A  83
VAL A  84
ALA A  77
 None
 0.99A 1fo4B-4o93A:
undetectable		 1fo4B-4o93A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 PHE B 190
THR B 164
VAL B 165
ALA B 158
 None
 1.04A 1fo4B-4o9uB:
undetectable		 1fo4B-4o9uB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 ARG A 318
THR A 272
VAL A 273
ALA A 310
 None
 1.09A 1fo4B-4rsmA:
1.1		 1fo4B-4rsmA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 SER A 263
THR A  77
VAL A  78
ALA A  81
 None
 0.86A 1fo4B-4tx8A:
undetectable		 1fo4B-4tx8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ARG A1095
PHE A1153
VAL A1087
ALA A1129
 None
 1.07A 1fo4B-4u14A:
undetectable		 1fo4B-4u14A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgg DOUBLE BOND
REDUCTASE

(Zingiber
officinale) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 SER A 167
PHE A 165
VAL A 238
ALA A 245
 None
None
NAP  A 400 ( 4.5A)
None
 1.09A 1fo4B-4wggA:
undetectable		 1fo4B-4wggA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		4 SER A  68
PHE A  74
THR A 111
VAL A 110
 None
 1.04A 1fo4B-4xz7A:
undetectable		 1fo4B-4xz7A:
14.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
ALA A1078
 URC  A3007 (-3.0A)
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
URC  A3007 (-3.5A)
 0.38A 1fo4B-4yswA:
45.6		 1fo4B-4yswA:
86.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A 842
THR A 832
VAL A 831
ALA A 797
 None
 1.09A 1fo4B-5c7mA:
undetectable		 1fo4B-5c7mA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cej 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Yersinia pestis) 		PF13561
(adh_short_C2) 		4 SER A  65
THR A  68
VAL A  69
ALA A 120
 None
 1.10A 1fo4B-5cejA:
undetectable		 1fo4B-5cejA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 SER A 453
ARG A 774
PHE A  36
VAL A 449
 None
U  B  72 ( 3.1A)
None
None
 1.09A 1fo4B-5czzA:
2.8		 1fo4B-5czzA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		4 ARG A  48
THR A 124
VAL A 125
ALA A 120
 None
 0.99A 1fo4B-5fifA:
undetectable		 1fo4B-5fifA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLU F 760
THR F 739
VAL F 738
ALA F 665
 None
 1.11A 1fo4B-5gjwF:
undetectable		 1fo4B-5gjwF:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 GLU A2388
ARG A2322
THR A2399
ALA A1428
 None
 1.07A 1fo4B-5h64A:
undetectable		 1fo4B-5h64A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		4 SER A 149
THR A 114
VAL A 113
ALA A 173
 None
 1.03A 1fo4B-5j5dA:
undetectable		 1fo4B-5j5dA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 GLU K  91
ARG K  83
THR K 190
ALA K  88
 ANP  K 501 (-3.5A)
ANP  K 501 (-4.3A)
None
ANP  K 501 ( 4.2A)
 0.98A 1fo4B-5mm7K:
undetectable		 1fo4B-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnb ISATIN HYDROLASE A

(Labrenzia
aggregata) 		no annotation 4 SER A 165
THR A 189
VAL A 190
ALA A 206
 None
 0.98A 1fo4B-5nnbA:
undetectable		 1fo4B-5nnbA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		4 PHE A 364
THR A 224
VAL A 227
ALA A 367
 OLC  A 529 (-3.1A)
OLC  A 539 ( 2.5A)
OLC  A 530 ( 4.5A)
OLC  A 530 (-2.9A)
 1.09A 1fo4B-5t77A:
undetectable		 1fo4B-5t77A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tws HUMAN DNA POLYMERASE
MU

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 PHE A 427
THR A 314
VAL A 315
ALA A 422
 None
 0.90A 1fo4B-5twsA:
undetectable		 1fo4B-5twsA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 PHE B 190
THR B 164
VAL B 165
ALA B 158
 None
None
PEG  B 308 ( 4.1A)
None
 1.04A 1fo4B-5uniB:
undetectable		 1fo4B-5uniB:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 ARG A  68
PHE A  39
THR A  97
VAL A 100
ALA A  46
 None
 1.24A 1fo4B-5vyoA:
undetectable		 1fo4B-5vyoA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w10 CGMP-SPECIFIC
PHOSPHODIESTERASE

(Leptospira
interrogans) 		PF01590
(GAF) 		4 GLU A 136
ARG A 104
VAL A  99
ALA A 122
 CMP  A 201 (-2.7A)
None
None
None
 0.93A 1fo4B-5w10A:
undetectable		 1fo4B-5w10A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 GLU A 536
THR A 923
VAL A 922
ALA A 785
 None
 1.08A 1fo4B-5wugA:
undetectable		 1fo4B-5wugA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmc E3 UBIQUITIN-PROTEIN
LIGASE ITCHY

(Mus musculus) 		PF00397
(WW)
PF00632
(HECT) 		4 PHE A 803
THR A 793
VAL A 792
ALA A 758
 None
 1.05A 1fo4B-5xmcA:
undetectable		 1fo4B-5xmcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 SER A 696
ARG A 693
VAL A 636
ALA A 688
 None
 1.04A 1fo4B-6aunA:
undetectable		 1fo4B-6aunA:
5.25