SIMILAR PATTERNS OF AMINO ACIDS FOR 1FO4_A_SALA3005

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 LEU A  18
PHE A  45
VAL A  24
LEU A  37
ALA A  42
 None
 1.04A 1fo4A-1dj2A:
0.0		 1fo4A-1dj2A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		5 LEU A  17
PHE A  44
VAL A  23
LEU A  36
ALA A  41
 None
 1.02A 1fo4A-1dj3A:
undetectable		 1fo4A-1dj3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		5 LEU A 366
PHE A  29
VAL A  89
LEU A  91
ALA A  31
 None
 1.42A 1fo4A-1f6dA:
0.0		 1fo4A-1f6dA:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		9 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.34A 1fo4A-1n5xA:
46.6		 1fo4A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.20A 1fo4A-1n5xA:
46.6		 1fo4A-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A 165
PHE A  52
THR A  65
VAL A  66
ALA A  60
 None
None
None
None
CAA  A 501 ( 3.7A)
 1.37A 1fo4A-1q51A:
0.0		 1fo4A-1q51A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a67 ISOCHORISMATASE
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF00857
(Isochorismatase) 		5 GLU A  16
LEU A  22
SER A 136
VAL A  28
LEU A  29
 None
 1.45A 1fo4A-2a67A:
0.0		 1fo4A-2a67A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		5 LEU A 386
THR A 324
VAL A 323
LEU A 339
ALA A 382
 None
 1.22A 1fo4A-2eceA:
undetectable		 1fo4A-2eceA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7r MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A 110
SER A 107
THR A 104
VAL A 103
LEU A  30
 None
 1.43A 1fo4A-2g7rA:
undetectable		 1fo4A-2g7rA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 296
ARG A 305
PHE A 111
THR A  61
VAL A 271
 None
MLR  A2913 (-3.0A)
None
None
None
 1.32A 1fo4A-2gh9A:
0.0		 1fo4A-2gh9A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 160
THR B  12
VAL B  48
LEU B   8
ALA B  51
 None
 1.38A 1fo4A-2iwgB:
undetectable		 1fo4A-2iwgB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4m UPF0146 PROTEIN
MTH_1000

(Methanothermobacter
thermautotrophicus) 		PF03686
(UPF0146) 		5 LEU A  92
SER A  33
VAL A  60
LEU A  62
ALA A  26
 None
 1.28A 1fo4A-2k4mA:
undetectable		 1fo4A-2k4mA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 1fo4A-2w55B:
43.4		 1fo4A-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.39A 1fo4A-2x8xX:
undetectable		 1fo4A-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		5 LEU A 167
PHE A  81
THR A  63
VAL A  66
LEU A  71
 None
 1.14A 1fo4A-3bujA:
1.0		 1fo4A-3bujA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmt PROTEIN SEQA

(Escherichia
coli) 		PF03925
(SeqA)
PF17206
(SeqA_N) 		5 LEU A  29
ARG A  25
VAL A   6
LEU A  10
ALA A  15
 None
 1.11A 1fo4A-3fmtA:
undetectable		 1fo4A-3fmtA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyk 27KDA OUTER MEMBRANE
PROTEIN

(Ruegeria
pomeroyi) 		PF13462
(Thioredoxin_4) 		5 LEU A 151
PHE A 139
VAL A  24
LEU A   5
ALA A 134
 None
 1.42A 1fo4A-3gykA:
undetectable		 1fo4A-3gykA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj9 OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		PF00881
(Nitroreductase) 		5 SER A  86
ARG A  82
THR A  91
VAL A  92
ALA A  72
 None
 1.43A 1fo4A-3hj9A:
undetectable		 1fo4A-3hj9A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 435
SER A 433
PHE A1129
VAL A 844
LEU A 860
 None
 1.45A 1fo4A-3ikmA:
undetectable		 1fo4A-3ikmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 283
SER A 284
ARG A 281
LEU A 303
ALA A 277
 None
 1.42A 1fo4A-3oeeA:
undetectable		 1fo4A-3oeeA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
 RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
 0.31A 1fo4A-3sr6C:
52.6		 1fo4A-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
 None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
 1.20A 1fo4A-3sr6C:
52.6		 1fo4A-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		5 GLU A 115
LEU A 114
THR A  62
VAL A  63
LEU A  64
 None
 1.46A 1fo4A-3ujpA:
0.5		 1fo4A-3ujpA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 SER A 488
ARG A 487
VAL A 491
LEU A 471
ALA A 475
 None
 1.15A 1fo4A-4c7gA:
undetectable		 1fo4A-4c7gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		5 LEU A 158
ARG A 315
PHE A 143
VAL A 148
LEU A 149
 None
 1.49A 1fo4A-4dteA:
undetectable		 1fo4A-4dteA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		5 LEU A 265
SER A 266
THR A 100
LEU A 105
ALA A 418
 None
 1.31A 1fo4A-4m8jA:
undetectable		 1fo4A-4m8jA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 LEU A 187
SER A 200
PHE A 215
VAL A 202
ALA A 212
 None
 1.37A 1fo4A-4muoA:
undetectable		 1fo4A-4muoA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU B  22
SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.07A 1fo4A-4nfuB:
undetectable		 1fo4A-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		5 LEU A 351
THR A 219
VAL A 250
LEU A 226
ALA A 217
 None
 1.40A 1fo4A-4pxqA:
1.2		 1fo4A-4pxqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.10A 1fo4A-4rlvA:
undetectable		 1fo4A-4rlvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 LEU A2336
THR A2381
VAL A2380
LEU A2383
ALA A2389
 None
 1.36A 1fo4A-4rlvA:
undetectable		 1fo4A-4rlvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		5 LEU A  49
ARG A  56
VAL A  35
LEU A   4
ALA A  57
 None
 1.43A 1fo4A-4tn5A:
undetectable		 1fo4A-4tn5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 LEU A  58
SER A   9
THR A  29
VAL A  28
ALA A  54
 None
None
SO4  A1276 (-4.0A)
None
None
 1.29A 1fo4A-4udnA:
0.8		 1fo4A-4udnA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG

(Paracoccus
denitrificans) 		PF03150
(CCP_MauG) 		5 LEU A 358
ARG A  39
THR A 275
VAL A 272
LEU A 287
 None
 1.36A 1fo4A-4y5rA:
undetectable		 1fo4A-4y5rA:
13.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1079
 URC  A3007 (-3.0A)
None
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
None
URC  A3007 (-3.4A)
 0.44A 1fo4A-4yswA:
45.7		 1fo4A-4yswA:
86.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Aeropyrum
pernix) 		PF13561
(adh_short_C2) 		5 GLU A  47
LEU A  51
SER A  53
ARG A  49
VAL A  30
 None
 1.37A 1fo4A-5b1yA:
0.8		 1fo4A-5b1yA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		5 LEU A  72
SER A  71
VAL A  65
LEU A 107
ALA A 127
 None
SAH  A 400 ( 4.8A)
None
None
None
 1.39A 1fo4A-5f2oA:
undetectable		 1fo4A-5f2oA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		5 LEU A1408
ARG A1389
VAL A1471
LEU A1436
ALA A1466
 None
 1.47A 1fo4A-5f3yA:
2.5		 1fo4A-5f3yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhq TANKYRASE-1

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13606
(Ank_3) 		5 LEU A 493
THR A 541
VAL A 540
LEU A 543
ALA A 549
 None
 1.39A 1fo4A-5jhqA:
undetectable		 1fo4A-5jhqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 LEU A 765
PHE A 760
THR A 688
LEU A 789
ALA A 685
 None
 1.36A 1fo4A-5mqmA:
undetectable		 1fo4A-5mqmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 ARG A 304
THR A 142
VAL A 141
LEU A 249
ALA A 272
 None
 1.45A 1fo4A-5mscA:
undetectable		 1fo4A-5mscA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		5 LEU B 260
SER B 261
PHE B 122
VAL B  25
LEU B  29
 None
 1.47A 1fo4A-5odrB:
undetectable		 1fo4A-5odrB:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 5 LEU A 201
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.44A 1fo4A-5vyeA:
undetectable		 1fo4A-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 5 LEU A 217
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.38A 1fo4A-5vyeA:
undetectable		 1fo4A-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 5 LEU A 353
SER A 357
VAL A 401
LEU A 405
ALA A 387
 None
 1.43A 1fo4A-5wzkA:
undetectable		 1fo4A-5wzkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y0q UPF0348 PROTEIN
B4417_3650

(Bacillus
subtilis) 		no annotation 5 LEU A 254
SER A 257
THR A 260
VAL A 261
LEU A 266
 None
 1.49A 1fo4A-5y0qA:
undetectable		 1fo4A-5y0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.08A 1fo4A-5y4dA:
undetectable		 1fo4A-5y4dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A2336
THR A2381
VAL A2380
LEU A2383
ALA A2389
 None
 1.33A 1fo4A-5y4dA:
undetectable		 1fo4A-5y4dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4e ANKYRIN-2,ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A1270
SER A1274
VAL A1314
LEU A1317
ALA A1323
 None
None
SO4  A1507 (-4.7A)
None
None
 1.15A 1fo4A-5y4eA:
undetectable		 1fo4A-5y4eA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 LEU A 483
SER A 498
PHE A 500
THR A 370
LEU A 375
 None
 1.27A 1fo4A-5ykbA:
undetectable		 1fo4A-5ykbA:
18.40