SIMILAR PATTERNS OF AMINO ACIDS FOR 1FMO_E_ADNE351

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  70
GLY A  71
VAL A  78
ALA A  91
ASN A 191
LEU A 193
THR A 206
ASP A 207
 STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 (-4.5A)
STU  A 401 (-4.7A)
STU  A 401 (-3.2A)
STU  A 401 (-3.6A)
 0.72A 1fmoE-1nxkA:
22.4		 1fmoE-1nxkA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  70
GLY A  71
VAL A  78
ALA A  91
VAL A 118
ASN A 191
THR A 206
ASP A 207
 STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
None
STU  A 401 (-4.5A)
STU  A 401 (-3.2A)
STU  A 401 (-3.6A)
 0.64A 1fmoE-1nxkA:
22.4		 1fmoE-1nxkA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
ASN A 816
LEU A 818
 None
 0.58A 1fmoE-1rjbA:
20.2		 1fmoE-1rjbA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
VAL A 675
ASN A 816
LEU A 818
ASP A 829
 None
 0.62A 1fmoE-1rjbA:
20.2		 1fmoE-1rjbA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
ASN A 797
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
None
STI  A   3 (-4.4A)
 0.66A 1fmoE-1t46A:
21.4		 1fmoE-1t46A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
ASN A 466
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-4.2A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.46A 1fmoE-1u59A:
23.9		 1fmoE-1u59A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
GLU A  91
ASN A 135
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 ( 4.7A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.49A 1fmoE-1zltA:
26.6		 1fmoE-1zltA:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 VAL A 259
ALA A 272
VAL A 307
VAL A 326
ASN A 374
LEU A 376
THR A 386
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.4A)
BI1  A1000 (-3.9A)
None
BI1  A1000 (-4.8A)
BI1  A1000 (-3.2A)
BI1  A1000 (-4.5A)
 0.78A 1fmoE-1zrzA:
35.9		 1fmoE-1zrzA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
ASP A 161
 None
None
None
GOL  A3001 (-3.5A)
GOL  A3001 (-3.8A)
None
None
 0.58A 1fmoE-2a2aA:
28.6		 1fmoE-2a2aA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
GLY X  18
VAL X  25
ALA X  37
VAL X  67
ASN X 135
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.51A 1fmoE-2dq7X:
25.4		 1fmoE-2dq7X:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
VAL A 323
ASN A 391
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.87A 1fmoE-2h8hA:
22.1		 1fmoE-2h8hA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
GLY A 249
VAL A 256
ALA A 269
VAL A 299
ASN A 368
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.6A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 0.58A 1fmoE-2hz0A:
23.7		 1fmoE-2hz0A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  38
GLY A  39
VAL A  46
ALA A  59
ASN A 168
LEU A 170
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.7A)
HB1  A1289 (-4.2A)
 0.68A 1fmoE-2iwiA:
26.7		 1fmoE-2iwiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 GLY A 429
VAL A 436
ALA A 452
VAL A 484
ASN A 551
LEU A 553
ASP A 564
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.72A 1fmoE-2j0jA:
22.4		 1fmoE-2j0jA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  29
GLY A  30
VAL A  37
ALA A  50
VAL A  82
VAL A 101
ASN A 149
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
J60  A1305 ( 4.7A)
J60  A1305 (-3.9A)
None
 0.76A 1fmoE-2jamA:
19.7		 1fmoE-2jamA:
30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU X  70
GLY X  71
VAL X  78
ALA X  91
ASN X 191
LEU X 193
THR X 206
ASP X 207
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.4A)
F10  X 401 (-3.8A)
F10  X 401 (-3.4A)
 0.92A 1fmoE-2p3gX:
20.4		 1fmoE-2p3gX:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU X  70
GLY X  71
VAL X  78
ALA X  91
VAL X 118
ASN X 191
THR X 206
ASP X 207
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
None
None
F10  X 401 (-3.8A)
F10  X 401 (-3.4A)
 0.78A 1fmoE-2p3gX:
20.4		 1fmoE-2p3gX:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		9 LEU A  25
GLY A  26
VAL A  33
ALA A  46
GLU A 110
ASN A 154
LEU A 156
THR A 166
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.3A)
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
MN  A 382 (-2.0A)
 0.70A 1fmoE-2phkA:
30.7		 1fmoE-2phkA:
29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		8 GLY B  48
VAL B  55
ALA B  67
VAL B  98
ASN B 169
LEU B 171
THR B 181
ASP B 182
 None
 0.81A 1fmoE-2qkwB:
22.8		 1fmoE-2qkwB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 724
GLY A 725
VAL A 732
ALA A 749
VAL A 781
ASN A 848
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 ( 4.7A)
None
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.91A 1fmoE-2r4bA:
21.8		 1fmoE-2r4bA:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  83
VAL A  90
ALA A 103
VAL A 137
ASN A 203
LEU A 205
ASP A 216
PHE A 368
 ANP  A1480 ( 4.3A)
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-4.7A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
ANP  A1480 (-4.5A)
 0.80A 1fmoE-2v55A:
4.6		 1fmoE-2v55A:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
GLY A  20
VAL A  27
ALA A  40
VAL A  96
ASN A 144
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-3.9A)
AMP  A1302 ( 4.8A)
AMP  A1302 (-3.1A)
 0.62A 1fmoE-2yabA:
22.2		 1fmoE-2yabA:
25.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  68
GLY A  69
VAL A  76
ALA A  92
VAL A 125
ASN A 192
LEU A 194
THR A 204
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
STU  A   1 ( 3.8A)
 0.50A 1fmoE-2z7rA:
31.9		 1fmoE-2z7rA:
34.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
GLY A1003
VAL A1010
ALA A1028
VAL A1060
ASN A1137
ASP A1150
 S91  A   1 ( 4.1A)
S91  A   1 ( 3.9A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
None
 0.74A 1fmoE-2z8cA:
26.0		 1fmoE-2z8cA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
VAL A  74
VAL A  93
ASN A 141
LEU A 143
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 3.7A)
None
5CP  A 600 (-4.4A)
5CP  A 600 (-3.5A)
 0.74A 1fmoE-3bhhA:
22.8		 1fmoE-3bhhA:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 202
VAL A 209
ALA A 220
VAL A 249
ASN A 319
LEU A 321
ASP A 332
 None
 0.78A 1fmoE-3d7uA:
24.5		 1fmoE-3d7uA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		7 LEU A  29
GLY A  30
VAL A  37
ALA A  50
GLU A 107
ASN A 151
ASP A 167
 None
 0.77A 1fmoE-3dxnA:
25.5		 1fmoE-3dxnA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		7 LEU A  29
GLY A  30
VAL A  37
ALA A  50
GLU A 107
ASN A 151
LEU A 153
 None
 0.59A 1fmoE-3dxnA:
25.5		 1fmoE-3dxnA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
GLY A  45
VAL A  52
ALA A  65
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.72A 1fmoE-3f2aA:
23.0		 1fmoE-3f2aA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
GLY A  60
VAL A  67
ALA A  80
VAL A 113
ASN A 184
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
None
STU  A   1 ( 4.9A)
STU  A   1 (-4.4A)
 0.56A 1fmoE-3fmeA:
22.4		 1fmoE-3fmeA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 105
VAL A 112
ALA A 125
VAL A 160
ASN A 227
LEU A 229
THR A 239
 None
None
GMG  A   1 (-3.4A)
None
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
GMG  A   1 (-3.8A)
 0.64A 1fmoE-3hdnA:
25.0		 1fmoE-3hdnA:
39.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
ALA A 859
VAL A 892
ASN A1027
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
None
None
None
 0.77A 1fmoE-3hngA:
21.3		 1fmoE-3hngA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 892
ASN A1027
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
None
None
 0.66A 1fmoE-3hngA:
21.3		 1fmoE-3hngA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
ASN A 204
LEU A 206
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A 542 ( 4.8A)
GOL  A 542 ( 4.6A)
J60  A 540 ( 3.6A)
 0.71A 1fmoE-3hztA:
21.5		 1fmoE-3hztA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
GLY A 681
VAL A 689
ALA A 700
ASN A 802
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
MG  A2102 ( 2.9A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.75A 1fmoE-3lj0A:
23.6		 1fmoE-3lj0A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 171
GLY A 172
VAL A 179
ALA A 192
VAL A 224
ASN A 291
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
 0.68A 1fmoE-3mtlA:
23.8		 1fmoE-3mtlA:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
VAL A 104
VAL A 123
GLU A 127
ASN A 171
LEU A 173
THR A 183
ASP A 184
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.2A)
None
XFE  A 351 (-4.6A)
XFE  A 351 (-3.7A)
None
XFE  A 351 (-4.4A)
 0.47A 1fmoE-3mvjA:
54.0		 1fmoE-3mvjA:
98.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  88
GLY A  89
VAL A  96
ALA A 109
VAL A 143
GLU A 166
ASN A 210
LEU A 212
THR A 222
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
None
None
JOZ  A 361 (-3.7A)
SO4  A   5 ( 4.5A)
 0.88A 1fmoE-3nuuA:
35.1		 1fmoE-3nuuA:
36.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
GLY A 193
VAL A 200
ALA A 213
VAL A 247
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.63A 1fmoE-3nyoA:
37.5		 1fmoE-3nyoA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 726
GLY A 727
VAL A 734
ALA A 751
ASN A 850
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.72A 1fmoE-3pp0A:
24.6		 1fmoE-3pp0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
VAL A 565
ALA A 576
VAL A 609
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.76A 1fmoE-3ppzA:
26.2		 1fmoE-3ppzA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
VAL A  71
ALA A  84
GLU A 151
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.1A)
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.71A 1fmoE-3q5iA:
28.2		 1fmoE-3q5iA:
26.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  83
VAL A  90
ALA A 103
ASN A 205
LEU A 207
ASP A 218
PHE A 370
 NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
None
NM7  A 416 ( 4.2A)
EDO  A 417 (-3.7A)
NM7  A 416 (-3.3A)
 0.77A 1fmoE-3qfvA:
35.8		 1fmoE-3qfvA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  50
GLY A  51
VAL A  58
ALA A  71
VAL A  98
ASN A 171
LEU A 173
THR A 186
ASP A 187
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
None
I85  A 350 (-4.4A)
None
I85  A 350 ( 4.0A)
I85  A 350 (-3.3A)
 0.66A 1fmoE-3sheA:
20.6		 1fmoE-3sheA:
29.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 361
GLY A 362
VAL A 369
ALA A 382
VAL A 436
ASN A 484
LEU A 486
ASP A 497
PHE A 644
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.8A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
None
 0.53A 1fmoE-3txoA:
24.5		 1fmoE-3txoA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
GLY A  76
VAL A  83
ALA A  96
VAL A 128
ASN A 196
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
MG  A 402 ( 2.9A)
ANP  A 401 (-4.8A)
 0.76A 1fmoE-3wigA:
24.2		 1fmoE-3wigA:
27.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
VAL A  18
ALA A  31
VAL A  63
ASN A 130
LEU A 132
ASP A 143
 38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.75A 1fmoE-3zduA:
25.5		 1fmoE-3zduA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 899
ASN A1033
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-3.5A)
B49  A2000 ( 4.6A)
None
B49  A2000 (-4.5A)
 0.54A 1fmoE-4agdA:
20.3		 1fmoE-4agdA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
ALA A  31
VAL A  64
VAL A  83
ASN A 131
LEU A 133
ASP A 144
 TC0  A 500 ( 4.2A)
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-4.4A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.71A 1fmoE-4bbmA:
23.3		 1fmoE-4bbmA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
VAL A  64
VAL A  83
ASN A 131
LEU A 133
ASP A 144
 None
TC0  A 500 (-3.5A)
TC0  A 500 (-4.7A)
TC0  A 500 (-4.4A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.71A 1fmoE-4bbmA:
23.3		 1fmoE-4bbmA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
GLY A  23
VAL A  30
ALA A  43
VAL A  96
ASN A 144
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.84A 1fmoE-4cfhA:
31.7		 1fmoE-4cfhA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
VAL A 721
ASN A 787
LEU A 789
ASP A 800
PHE A 946
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
AGS  A1985 (-4.8A)
 0.57A 1fmoE-4crsA:
39.3		 1fmoE-4crsA:
37.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
IOD  A 402 ( 3.4A)
 0.57A 1fmoE-4eutA:
21.7		 1fmoE-4eutA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
IOD  A 402 ( 3.4A)
BX7  A 401 ( 3.7A)
 0.74A 1fmoE-4eutA:
21.7		 1fmoE-4eutA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
THR A 156
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
IOD  A 402 ( 3.5A)
BX7  A 401 (-3.6A)
 0.65A 1fmoE-4euuA:
26.3		 1fmoE-4euuA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
None
IOD  A 402 ( 3.5A)
BX7  A 401 (-3.6A)
 0.74A 1fmoE-4euuA:
26.3		 1fmoE-4euuA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  26
GLY A  27
VAL A  34
ALA A  47
VAL A  79
VAL A  98
ASN A 146
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-3.9A)
ATP  A 401 (-3.4A)
ATP  A 401 (-4.6A)
 0.66A 1fmoE-4fg8A:
24.5		 1fmoE-4fg8A:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  26
GLY A  27
VAL A  34
ALA A  47
VAL A  79
VAL A  98
GLU A 102
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-4.7A)
ATP  A 401 (-3.9A)
ATP  A 401 (-3.7A)
ATP  A 401 (-4.6A)
 0.58A 1fmoE-4fg8A:
24.5		 1fmoE-4fg8A:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  30
VAL A  37
ALA A  50
VAL A  84
ASN A 151
LEU A 153
THR A 163
ASP A 164
 STU  A 401 (-3.3A)
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 (-3.8A)
STU  A 401 ( 3.9A)
 0.67A 1fmoE-4fr4A:
31.7		 1fmoE-4fr4A:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
VAL A 863
ALA A 880
VAL A 911
LEU A 983
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
None
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.76A 1fmoE-4gl9A:
24.2		 1fmoE-4gl9A:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 156
GLY A 157
VAL A 164
ALA A 177
GLU A 234
ASN A 279
THR A 291
PHE A 438
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 505 ( 2.9A)
0XZ  A 501 ( 4.5A)
0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.8A)
 0.70A 1fmoE-4gv1A:
40.8		 1fmoE-4gv1A:
39.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
GLY A 829
VAL A 836
ALA A 853
VAL A 884
ASN A 954
LEU A 956
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.68A 1fmoE-4hviA:
24.4		 1fmoE-4hviA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
GLY A 407
VAL A 414
ALA A 427
VAL A 453
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.60A 1fmoE-4idtA:
26.1		 1fmoE-4idtA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
ASP A 157
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.5A)
None
 0.87A 1fmoE-4jlcA:
17.6		 1fmoE-4jlcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
VAL A 486
ALA A 506
ASN A 622
LEU A 624
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
MG  A 802 ( 2.4A)
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.64A 1fmoE-4k33A:
24.7		 1fmoE-4k33A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A  43
VAL A  50
ALA A  61
VAL A  90
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.63A 1fmoE-4l52A:
23.6		 1fmoE-4l52A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
VAL A  54
ALA A  67
VAL A  99
ASN A 178
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.5A)
None
 0.72A 1fmoE-4o38A:
21.2		 1fmoE-4o38A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
VAL A 981
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-3.7A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.67A 1fmoE-4oliA:
24.2		 1fmoE-4oliA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 627
GLY A 628
VAL A 635
ALA A 648
VAL A 685
LEU A 753
ASP A 764
PHE A 910
 None
 0.59A 1fmoE-4otdA:
39.6		 1fmoE-4otdA:
36.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  24
GLY A  25
VAL A  32
ALA A  45
VAL A  98
ASN A 146
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.61A 1fmoE-4rewA:
31.4		 1fmoE-4rewA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
ASN A 816
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
None
P30  A1001 (-4.6A)
 0.64A 1fmoE-4rt7A:
15.4		 1fmoE-4rt7A:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		12 LEU A 104
GLY A 105
VAL A 112
ALA A 125
VAL A 159
VAL A 178
GLU A 182
ASN A 226
LEU A 228
THR A 238
ASP A 239
PHE A 382
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.2A)
ATP  A 501 (-3.5A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ATP  A 501 (-3.1A)
ZN  A 503 (-1.9A)
ATP  A 501 (-4.5A)
 0.34A 1fmoE-4wb7A:
53.3		 1fmoE-4wb7A:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
VAL A  60
ALA A  72
VAL A 104
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.50A 1fmoE-4wsqA:
26.0		 1fmoE-4wsqA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 166
VAL A 173
ALA A 186
VAL A 222
ASN A 292
LEU A 294
ASP A 307
 4E1  A 505 (-3.5A)
4E1  A 505 (-4.5A)
4E1  A 505 (-3.5A)
None
None
None
4E1  A 505 (-3.6A)
 0.73A 1fmoE-4yljA:
25.6		 1fmoE-4yljA:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
GLY A  35
VAL A  42
ALA A  55
GLU A 112
ASN A 156
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-3.5A)
MG  A 505 ( 2.7A)
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.52A 1fmoE-4ysjA:
30.8		 1fmoE-4ysjA:
25.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLY A  63
VAL A  70
ALA A  83
VAL A 116
ASN A 183
LEU A 185
ASP A 196
 5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.1A)
None
5RC  A4000 (-3.6A)
 0.74A 1fmoE-5es1A:
28.2		 1fmoE-5es1A:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
VAL A 981
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.57A 1fmoE-5f1zA:
24.5		 1fmoE-5f1zA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
VAL A 607
ALA A 625
VAL A 658
ASN A 823
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
None
748  A1001 (-4.3A)
 0.63A 1fmoE-5grnA:
14.3		 1fmoE-5grnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		10 LEU A  20
GLY A  21
VAL A  28
ALA A  41
VAL A  74
VAL A  93
GLU A  97
ASN A 141
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.0A)
ADP  A 301 (-3.5A)
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.58A 1fmoE-5hu3A:
31.0		 1fmoE-5hu3A:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
VAL A  65
ALA A  77
VAL A 109
ASN A 185
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.1A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.59A 1fmoE-5i3oA:
25.8		 1fmoE-5i3oA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		7 VAL A  78
VAL A  97
GLU A 101
ASN A 145
LEU A 147
THR A 160
ASP A 161
 None
 0.73A 1fmoE-5ig1A:
28.6		 1fmoE-5ig1A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
ALA A  43
VAL A  96
GLU A 100
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.3A)
STU  A 601 (-4.0A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.77A 1fmoE-5isoA:
31.3		 1fmoE-5isoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
GLY A  23
VAL A  30
ALA A  43
VAL A  96
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.60A 1fmoE-5isoA:
31.3		 1fmoE-5isoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  23
VAL A  30
ALA A  43
VAL A  74
ASN A 141
LEU A 143
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.45A 1fmoE-5j5tA:
24.1		 1fmoE-5j5tA:
24.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 397
VAL A 404
ALA A 417
VAL A 449
VAL A 468
LEU A 518
ASP A 533
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.65A 1fmoE-5jznA:
25.3		 1fmoE-5jznA:
35.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 404
ALA A 417
VAL A 449
VAL A 468
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.62A 1fmoE-5jznA:
25.3		 1fmoE-5jznA:
35.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  49
ALA A  60
VAL A  94
ASN A 161
LEU A 163
THR A 173
ASP A 174
 None
STU  A 901 (-3.3A)
None
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
STU  A 901 (-4.1A)
 0.74A 1fmoE-5lohA:
26.4		 1fmoE-5lohA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 LEU A  44
GLY A  45
VAL A  52
ALA A  65
ASN A 172
LEU A 174
ASP A 186
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-4.8A)
None
 0.73A 1fmoE-5turA:
29.2		 1fmoE-5turA:
23.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  99
VAL A 106
ALA A 119
VAL A 153
LEU A 221
ASP A 232
PHE A 384
 None
 0.64A 1fmoE-5u7qA:
35.9		 1fmoE-5u7qA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
VAL A 153
ASN A 219
LEU A 221
ASP A 232
PHE A 384
 None
 0.67A 1fmoE-5u7qA:
35.9		 1fmoE-5u7qA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 8 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  72
VAL A  95
ASN A 143
ASP A 156
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
G93  A 301 (-4.1A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
 0.54A 1fmoE-5u94A:
27.6		 1fmoE-5u94A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 9 LEU A 686
GLY A 687
VAL A 694
ALA A 707
VAL A 738
VAL A 757
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-4.1A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.53A 1fmoE-5vilA:
21.9		 1fmoE-5vilA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 7 VAL A  27
ALA A  40
VAL A  98
ASN A 146
LEU A 148
THR A 158
ASP A 159
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-3.1A)
CJJ  A 301 (-4.3A)
 0.71A 1fmoE-6b2qA:
26.0		 1fmoE-6b2qA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 LEU A 366
GLY A 367
VAL A 374
ALA A 388
VAL A 422
ASN A 489
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
None
EE4  A 701 ( 4.9A)
DMS  A 702 ( 3.1A)
 0.76A 1fmoE-6c0tA:
41.6		 1fmoE-6c0tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A 366
GLY A 367
VAL A 374
ALA A 388
VAL A 422
GLU A 445
ASN A 489
PHE A 649
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
None
EE4  A 701 (-3.3A)
EE4  A 701 ( 4.9A)
None
 0.51A 1fmoE-6c0tA:
41.6		 1fmoE-6c0tA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
GLY A 882
VAL A 889
ALA A 906
VAL A 938
ASN A1008
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.63A 1fmoE-6c7yA:
24.2		 1fmoE-6c7yA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 GLY A  67
VAL A  74
ALA A  87
VAL A 120
ASN A 187
LEU A 189
ASP A 200
 None
 0.61A 1fmoE-6c9dA:
30.0		 1fmoE-6c9dA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 GLY A 172
VAL A 179
ALA A 192
VAL A 249
VAL A 270
ASN A 317
LEU A 319
ASP A 330
 F6J  A 501 ( 3.9A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
None
F6J  A 501 (-4.0A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
 0.51A 1fmoE-6cmjA:
24.0		 1fmoE-6cmjA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 8 LEU A 167
GLY A 168
VAL A 175
ALA A 189
VAL A 225
ASN A 293
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
None
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.76A 1fmoE-6fyoA:
25.4		 1fmoE-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 8 LEU A 167
GLY A 168
VAL A 175
ALA A 189
VAL A 225
ASN A 293
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
None
None
None
3NG  A 501 (-4.3A)
 0.78A 1fmoE-6fyvA:
25.5		 1fmoE-6fyvA:
undetectable