SIMILAR PATTERNS OF AMINO ACIDS FOR 1FML_A_RTLA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 LEU A 175
LEU A 178
HIS A 138
LEU A 280
ILE A 161
 None
 1.35A 1fmlA-1a2oA:
0.7		 1fmlA-1a2oA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3y DNA TOPOISOMERASE VI
A SUBUNIT

(Methanocaldococcus
jannaschii) 		PF04406
(TP6A_N) 		5 TYR A 175
LEU A 221
SER A 146
LEU A 236
ILE A 193
 None
 0.99A 1fmlA-1d3yA:
0.0		 1fmlA-1d3yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 TYR A 185
LEU A 246
HIS A 215
LEU A 219
ILE A 231
 None
 1.29A 1fmlA-1dq3A:
0.0		 1fmlA-1dq3A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 TYR A 151
LEU A 147
LEU A 144
LEU A 113
ILE A 115
 None
 1.37A 1fmlA-1exbA:
0.5		 1fmlA-1exbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		5 LEU A 226
LEU A 102
LEU A 147
ILE A 256
PHE A 138
 None
 1.28A 1fmlA-1fblA:
0.5		 1fmlA-1fblA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus;
Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
PF08720
(Hema_stalk) 		5 LEU B  93
LEU B  92
SER B  89
LEU A  36
ILE A 408
 None
 1.11A 1fmlA-1flcB:
undetectable		 1fmlA-1flcB:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		6 LEU A 138
LEU A 139
SER A 142
TYR A 298
ILE A 301
PHE A 310
 RTL  A 401 ( 4.6A)
None
RTL  A 401 (-3.2A)
RTL  A 401 (-4.2A)
None
RTL  A 401 (-4.3A)
 1.33A 1fmlA-1fmlA:
60.1		 1fmlA-1fmlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		12 TYR A 105
TYR A 112
TYR A 120
LEU A 138
LEU A 139
SER A 142
HIS A 164
HIS A 197
LEU A 201
TYR A 298
ILE A 303
PHE A 310
 RTL  A 401 (-4.6A)
RTL  A 401 ( 4.8A)
RTL  A 401 ( 4.5A)
RTL  A 401 ( 4.6A)
None
RTL  A 401 (-3.2A)
RTL  A 401 (-4.4A)
RTL  A 401 (-4.2A)
RTL  A 401 ( 4.3A)
RTL  A 401 (-4.2A)
RTL  A 401 ( 4.0A)
RTL  A 401 (-4.3A)
 0.00A 1fmlA-1fmlA:
60.1		 1fmlA-1fmlA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		5 TYR A 400
LEU A 680
HIS A 246
LEU A 407
ILE A 381
 None
 1.38A 1fmlA-1i6qA:
0.0		 1fmlA-1i6qA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj2 KB5-C20 T-CELL
RECEPTOR ALPHA-CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 TYR A  88
LEU A  46
LEU A  73
ILE A  64
PHE A  29
 None
 1.21A 1fmlA-1kj2A:
undetectable		 1fmlA-1kj2A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 TYR A 400
LEU A 682
LEU A 683
LEU A 407
ILE A 381
 None
 1.40A 1fmlA-1n76A:
undetectable		 1fmlA-1n76A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 TYR A 716
TYR A 722
TYR A 932
LEU A 668
LEU A 729
 CIT  A 969 (-4.1A)
None
None
None
None
 1.36A 1fmlA-1p2zA:
undetectable		 1fmlA-1p2zA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 TYR A 160
TYR A  91
LEU A  90
SER A 156
PHE A 209
 None
 1.35A 1fmlA-1ryyA:
undetectable		 1fmlA-1ryyA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		5 TYR A 388
LEU A 349
LEU A 356
TYR A 313
ILE A 353
 None
 1.24A 1fmlA-1venA:
undetectable		 1fmlA-1venA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		5 TYR 1 434
SER 1 460
HIS 1 244
HIS 1 352
ILE 1 424
 None
None
MN  1 602 (-3.3A)
MN  1 601 (-3.6A)
None
 1.16A 1fmlA-1wao1:
undetectable		 1fmlA-1wao1:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 TYR A 375
LEU A 369
LEU A 370
SER A 372
LEU A 219
 None
 1.14A 1fmlA-1wu2A:
undetectable		 1fmlA-1wu2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 LEU A 284
HIS A  31
TYR A 308
ILE A 307
PHE A 317
 None
 1.18A 1fmlA-1wzaA:
undetectable		 1fmlA-1wzaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100

(Porphyromonas
gingivalis) 		PF01869
(BcrAD_BadFG) 		5 LEU A 150
LEU A 153
SER A 219
LEU A 207
ILE A 203
 None
 1.41A 1fmlA-1zbsA:
undetectable		 1fmlA-1zbsA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zi7 KES1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		5 TYR A  64
TYR A 194
LEU A  83
TYR A 265
ILE A 250
 None
 1.39A 1fmlA-1zi7A:
undetectable		 1fmlA-1zi7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 268
LEU A 348
LEU A 352
LEU A 322
TYR A 333
 None
 1.26A 1fmlA-2f7lA:
undetectable		 1fmlA-2f7lA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmn METALLO-BETA-LACTAMA
SE

(Bradyrhizobium
diazoefficiens) 		PF00753
(Lactamase_B) 		5 LEU A 210
HIS A 242
HIS A 101
TYR A 223
ILE A 219
 None
ZN  A 802 (-3.2A)
ZN  A 801 (-3.2A)
None
None
 1.39A 1fmlA-2gmnA:
undetectable		 1fmlA-2gmnA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		5 TYR A 176
LEU A 239
LEU A 160
TYR A 165
ILE A 200
 None
 1.34A 1fmlA-2grmA:
undetectable		 1fmlA-2grmA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 TYR A 719
LEU A 722
LEU A 627
TYR A 622
PHE A 638
 None
 1.30A 1fmlA-2np0A:
undetectable		 1fmlA-2np0A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 TYR A 681
TYR A 687
TYR A 897
LEU A 633
LEU A 694
 MPD  A1704 ( 4.7A)
None
None
None
None
 1.41A 1fmlA-2obeA:
undetectable		 1fmlA-2obeA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		5 TYR A 105
LEU A 142
LEU A 135
HIS A  88
LEU A  48
 None
None
None
FE  A 501 (-3.1A)
None
 1.25A 1fmlA-2ohhA:
undetectable		 1fmlA-2ohhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 372
SER A 371
LEU A 405
TYR A 255
ILE A 254
 None
 1.29A 1fmlA-2p0uA:
undetectable		 1fmlA-2p0uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 LEU A  20
LEU A  17
HIS A 382
LEU A 169
ILE A 171
 None
 1.37A 1fmlA-2p6pA:
2.5		 1fmlA-2p6pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		5 LEU A 100
LEU A  99
HIS A 456
HIS A 364
ILE A  26
 None
None
ZN  A1567 (-3.6A)
ZN  A1565 (-3.2A)
None
 1.36A 1fmlA-2w9mA:
undetectable		 1fmlA-2w9mA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 LEU A 466
LEU A 456
HIS A 581
LEU A 489
ILE A 487
 None
 1.33A 1fmlA-2wmhA:
undetectable		 1fmlA-2wmhA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 LEU A 407
LEU A 440
HIS A 311
LEU A 393
ILE A  34
 None
 1.39A 1fmlA-2wnwA:
undetectable		 1fmlA-2wnwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Mus musculus) 		PF00017
(SH2)
PF16454
(PI3K_P85_iSH2) 		5 TYR B 680
TYR B 690
LEU B 683
TYR B 649
ILE B 640
 None
 1.38A 1fmlA-2y3aB:
undetectable		 1fmlA-2y3aB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqr KIAA0907 PROTEIN

(Homo sapiens) 		no annotation 5 TYR A  40
LEU A  54
HIS A  22
LEU A  97
ILE A  76
 None
 1.33A 1fmlA-2yqrA:
undetectable		 1fmlA-2yqrA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11

(Methanocaldococcus
jannaschii) 		PF00149
(Metallophos) 		5 LEU A  45
HIS A 128
LEU A 155
ILE A 154
PHE A 143
 None
 1.34A 1fmlA-3auzA:
undetectable		 1fmlA-3auzA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 LEU A  59
LEU A  60
HIS A  19
TYR A  36
ILE A   6
 None
 1.00A 1fmlA-3c5yA:
2.2		 1fmlA-3c5yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		5 TYR A 239
LEU A 237
SER A 227
HIS A 126
LEU A 102
 None
None
PMP  A 401 (-2.6A)
None
None
 1.18A 1fmlA-3cq5A:
undetectable		 1fmlA-3cq5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  93
LEU A  96
HIS A  47
LEU A   7
ILE A   4
 None
 1.25A 1fmlA-3dipA:
undetectable		 1fmlA-3dipA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		5 TYR A  41
LEU A  38
LEU A  39
HIS A 116
LEU A 118
 None
 1.35A 1fmlA-3dwvA:
undetectable		 1fmlA-3dwvA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 TYR A 730
LEU A 703
LEU A 704
HIS A 728
LEU A 696
 None
 1.40A 1fmlA-3eh1A:
undetectable		 1fmlA-3eh1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		5 TYR A 207
LEU A 357
LEU A 356
LEU A 304
ILE A 305
 None
 1.21A 1fmlA-3epjA:
6.6		 1fmlA-3epjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 231
LEU A 228
HIS A 303
LEU A 182
PHE A 132
 None
 1.23A 1fmlA-3f2aA:
undetectable		 1fmlA-3f2aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 TYR A 413
LEU A 417
LEU A 448
TYR A 444
ILE A 447
 None
 1.38A 1fmlA-3gitA:
undetectable		 1fmlA-3gitA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 TYR A 434
SER A 460
HIS A 244
HIS A 352
ILE A 424
 None
None
ZN  A 501 ( 3.3A)
ZN  A 500 ( 3.2A)
None
 1.14A 1fmlA-3h68A:
undetectable		 1fmlA-3h68A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 LEU A 491
HIS A  93
LEU A 477
TYR A 556
ILE A 480
 None
 1.27A 1fmlA-3h7lA:
undetectable		 1fmlA-3h7lA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 TYR A  14
LEU A 100
HIS A  24
LEU A  19
ILE A   5
 None
 1.33A 1fmlA-3hwrA:
undetectable		 1fmlA-3hwrA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 TYR A 193
LEU A 190
SER A 194
LEU A 147
ILE A 142
 NAE  A 311 (-4.6A)
None
None
None
None
 1.15A 1fmlA-3i3oA:
undetectable		 1fmlA-3i3oA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 TYR A  81
LEU A 134
LEU A 127
HIS A  64
LEU A  27
 None
None
None
ZN  A 452 (-3.5A)
None
 1.27A 1fmlA-3ie1A:
undetectable		 1fmlA-3ie1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A  41
LEU A  44
SER A  40
HIS A  34
LEU A  16
 None
 1.34A 1fmlA-3kzwA:
undetectable		 1fmlA-3kzwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 LEU A  73
LEU A  76
HIS A 391
ILE A  95
PHE A 358
 None
 1.36A 1fmlA-3lmkA:
undetectable		 1fmlA-3lmkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lys PROPHAGE PI2 PROTEIN
01, INTEGRASE

(Lactococcus
lactis) 		PF14659
(Phage_int_SAM_3) 		5 TYR A  63
LEU A 138
SER A 134
TYR A 108
ILE A 103
 None
 1.00A 1fmlA-3lysA:
undetectable		 1fmlA-3lysA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lys PROPHAGE PI2 PROTEIN
01, INTEGRASE

(Lactococcus
lactis) 		PF14659
(Phage_int_SAM_3) 		5 TYR A  63
LEU A 138
SER A 134
TYR A 108
PHE A 115
 None
 1.28A 1fmlA-3lysA:
undetectable		 1fmlA-3lysA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma2 METALLOPROTEINASE
INHIBITOR 1

(Homo sapiens) 		PF00965
(TIMP) 		5 TYR B 372
TYR B 362
LEU B 394
LEU B 393
ILE B 358
 None
 1.38A 1fmlA-3ma2B:
undetectable		 1fmlA-3ma2B:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 TYR A 168
LEU A 103
LEU A  31
ILE A  24
PHE A  34
 None
 1.40A 1fmlA-3oukA:
undetectable		 1fmlA-3oukA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		5 TYR A 112
SER A  27
TYR A 159
ILE A  95
PHE A 164
 None
 1.38A 1fmlA-3ptkA:
undetectable		 1fmlA-3ptkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 TYR B 343
LEU B 404
LEU B 407
TYR B 365
ILE B 368
 None
 1.22A 1fmlA-3t5vB:
undetectable		 1fmlA-3t5vB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tca AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		5 TYR A 422
LEU A 337
LEU A 316
LEU A 387
ILE A 342
 None
 1.34A 1fmlA-3tcaA:
undetectable		 1fmlA-3tcaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A4229
LEU A4230
SER A4233
LEU A4187
ILE A4190
 None
 1.37A 1fmlA-3vkgA:
undetectable		 1fmlA-3vkgA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 TYR A 661
TYR A 667
TYR A 876
LEU A 615
LEU A 674
 None
 1.39A 1fmlA-3zifA:
undetectable		 1fmlA-3zifA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 LEU A  75
LEU A  74
HIS A 121
TYR A 118
ILE A  91
 None
None
None
EDO  A1368 (-3.5A)
None
 1.35A 1fmlA-3zwfA:
undetectable		 1fmlA-3zwfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drf METHYLTRANSFERASE
TYPE 12

(Ruminiclostridium
thermocellum) 		PF12623
(Hen1_L) 		5 LEU B 179
LEU B 178
LEU B  52
ILE B  93
PHE B  29
 None
 1.29A 1fmlA-4drfB:
undetectable		 1fmlA-4drfB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A 335
SER A 337
TYR A  80
ILE A 440
PHE A  79
 None
 1.33A 1fmlA-4epaA:
undetectable		 1fmlA-4epaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esb TRANSCRIPTIONAL
REGULATOR, PADR
FAMILY

(Bacillus cereus) 		PF03551
(PadR) 		5 TYR A  46
TYR A  24
TYR A  73
LEU A  28
ILE A  18
 None
SO4  A 201 (-4.7A)
GOL  A 202 (-4.2A)
None
None
 1.21A 1fmlA-4esbA:
undetectable		 1fmlA-4esbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 LEU A 133
LEU A 132
HIS A 186
LEU A 121
ILE A 119
 None
 1.25A 1fmlA-4g56A:
undetectable		 1fmlA-4g56A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 370
LEU A 199
TYR A 163
ILE A 196
PHE A 290
 None
 1.24A 1fmlA-4h3vA:
undetectable		 1fmlA-4h3vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 361
LEU A 360
HIS A 251
LEU A 276
ILE A 337
 None
 1.40A 1fmlA-4hlnA:
undetectable		 1fmlA-4hlnA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1t RNA-DIRECTED RNA
POLYMERASE L

(Cali
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		5 TYR A 146
LEU A  49
LEU A  46
TYR A 150
ILE A 151
 None
 1.26A 1fmlA-4i1tA:
undetectable		 1fmlA-4i1tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		5 TYR B 422
LEU B 337
LEU B 316
LEU B 387
ILE B 342
 None
 1.28A 1fmlA-4kvgB:
undetectable		 1fmlA-4kvgB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0h GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT F,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 LEU F  78
LEU F  83
SER F  81
LEU F  97
ILE F  93
 None
 1.35A 1fmlA-4n0hF:
undetectable		 1fmlA-4n0hF:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		5 TYR A 148
TYR A 100
LEU A 115
LEU A 112
ILE A 136
 None
 1.39A 1fmlA-4p3zA:
undetectable		 1fmlA-4p3zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph0 BLV CAPSID

(Bovine leukemia
virus) 		PF00607
(Gag_p24) 		5 LEU A  97
SER A 101
HIS A  70
LEU A  74
ILE A  78
 None
 1.14A 1fmlA-4ph0A:
undetectable		 1fmlA-4ph0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph3 BLV CAPSID

(Bovine leukemia
virus) 		PF00607
(Gag_p24) 		5 LEU A  97
SER A 101
HIS A  70
LEU A  74
ILE A  78
 None
None
None
None
IOD  A 207 ( 4.4A)
 1.18A 1fmlA-4ph3A:
undetectable		 1fmlA-4ph3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 TYR A 137
LEU A  16
LEU A 317
TYR A  12
ILE A  13
 None
 1.39A 1fmlA-4pl0A:
undetectable		 1fmlA-4pl0A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqs GLYCOSIDE HYDROLASE
FAMILY 43

(Halothermothrix
orenii) 		PF04616
(Glyco_hydro_43) 		5 TYR A 138
LEU A 167
TYR A  84
ILE A 129
PHE A  78
 None
 1.25A 1fmlA-4qqsA:
undetectable		 1fmlA-4qqsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		5 TYR A 214
TYR A 229
HIS A 181
LEU A 245
ILE A 197
 None
 1.26A 1fmlA-4qr8A:
undetectable		 1fmlA-4qr8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn0 UPF0141 PROTEIN YJDB

(Campylobacter
jejuni) 		PF00884
(Sulfatase) 		5 TYR A 400
LEU A 398
SER A 357
LEU A 405
TYR A 234
 None
 1.08A 1fmlA-4tn0A:
undetectable		 1fmlA-4tn0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		5 LEU A 248
LEU A 249
HIS A 143
TYR A  88
ILE A 271
 None
 1.41A 1fmlA-4twbA:
undetectable		 1fmlA-4twbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 GDNF FAMILY RECEPTOR
ALPHA-1

(Rattus
norvegicus) 		PF02351
(GDNF) 		5 TYR C 235
LEU C 212
TYR C 289
ILE C 342
PHE C 332
 None
 1.40A 1fmlA-4ux8C:
undetectable		 1fmlA-4ux8C:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyr FLOCCULATION PROTEIN
FLO11

(Saccharomyces
cerevisiae) 		PF10182
(Flo11) 		5 TYR A 113
TYR A 118
LEU A  93
LEU A 110
ILE A 120
 None
 1.31A 1fmlA-4uyrA:
undetectable		 1fmlA-4uyrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uys FLOCCULATION PROTEIN
FLO11

(Saccharomyces
cerevisiae) 		PF10182
(Flo11) 		5 TYR A 113
TYR A 118
LEU A  93
LEU A 110
ILE A 120
 None
 1.38A 1fmlA-4uysA:
undetectable		 1fmlA-4uysA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		5 TYR A 229
TYR A  81
HIS A  90
TYR A 112
PHE A 233
 None
 1.34A 1fmlA-4xacA:
undetectable		 1fmlA-4xacA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		5 TYR A 475
TYR A 360
LEU A 366
LEU A 369
ILE A 406
 None
 1.41A 1fmlA-4y7iA:
undetectable		 1fmlA-4y7iA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 TYR A 128
LEU A 136
LEU A 139
HIS A  93
ILE A  72
 None
None
None
CU  A 700 (-3.1A)
None
 1.21A 1fmlA-4z0zA:
undetectable		 1fmlA-4z0zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 435
LEU A 438
SER A 434
ILE A 373
PHE A 369
 None
 1.28A 1fmlA-5g4iA:
undetectable		 1fmlA-5g4iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 TYR A 587
LEU A 636
LEU A 633
HIS A 646
ILE A 750
 None
 1.20A 1fmlA-5gr1A:
undetectable		 1fmlA-5gr1A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		5 TYR A 965
LEU A 987
LEU A 986
HIS A 892
LEU A 957
 None
 1.18A 1fmlA-5hb3A:
undetectable		 1fmlA-5hb3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i20 UNCHARACTERIZED
PROTEIN

(Starkeya
novella) 		PF00892
(EamA) 		5 TYR A  99
LEU A 250
SER A  18
LEU A 243
ILE A 274
 OLC  A 301 ( 4.8A)
None
None
None
None
 1.39A 1fmlA-5i20A:
undetectable		 1fmlA-5i20A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 TYR A 525
LEU A 523
LEU A 530
TYR A 576
ILE A 527
 None
 1.36A 1fmlA-5k04A:
undetectable		 1fmlA-5k04A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 TYR A 343
TYR A 106
TYR A  78
LEU A  75
HIS A 186
 None
EDO  A 707 ( 4.5A)
EDO  A 707 (-4.6A)
None
None
 0.94A 1fmlA-5k8fA:
undetectable		 1fmlA-5k8fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		5 TYR A 101
LEU A 138
LEU A 130
HIS A  84
ILE A  40
 None
None
None
FEO  A 501 (-3.2A)
None
 1.19A 1fmlA-5lmcA:
undetectable		 1fmlA-5lmcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgy FAD:PROTEIN FMN
TRANSFERASE

(Pseudomonas
stutzeri) 		no annotation 5 TYR H 188
LEU H  72
LEU H  75
TYR H  48
ILE H 209
 None
 1.17A 1fmlA-5mgyH:
undetectable		 1fmlA-5mgyH:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		5 LEU A 405
LEU A 467
SER A 463
LEU A 452
ILE A 420
 None
 1.40A 1fmlA-5tgtA:
undetectable		 1fmlA-5tgtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 TYR B 556
LEU B 529
LEU B 530
HIS B 554
LEU B 522
 None
 1.39A 1fmlA-5vniB:
undetectable		 1fmlA-5vniB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 LEU A 368
LEU A 371
SER A 367
HIS A 600
PHE A 449
 None
None
None
SEB  A 360 ( 4.2A)
None
 1.20A 1fmlA-5ydjA:
undetectable		 1fmlA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 LEU A 368
LEU A 371
SER A 367
HIS A 600
PHE A 449
 None
 1.27A 1fmlA-6arxA:
undetectable		 1fmlA-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 5 LEU A 101
LEU A 104
SER A 100
HIS A  51
ILE A  59
 None
 1.27A 1fmlA-6bljA:
undetectable		 1fmlA-6bljA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjd -

(-) 		no annotation 5 TYR A  73
TYR A 113
LEU A  56
LEU A  99
PHE A  89
 None
 1.23A 1fmlA-6cjdA:
undetectable		 1fmlA-6cjdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 TYR A 165
LEU A 263
LEU A 196
LEU A 251
ILE A 237
 None
None
FMT  A 503 (-4.3A)
None
None
 1.23A 1fmlA-6cmjA:
undetectable		 1fmlA-6cmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-) 		no annotation 5 TYR A 241
LEU A 236
LEU A 237
LEU A 150
ILE A 158
 None
 1.14A 1fmlA-6d3iA:
undetectable		 1fmlA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 TYR A1962
LEU A1972
LEU A1971
SER A1961
LEU A1965
 None
 1.31A 1fmlA-6fb3A:
undetectable		 1fmlA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 5 TYR N  59
LEU N  33
LEU N  37
SER N  36
LEU N 106
 None
 1.22A 1fmlA-6g72N:
undetectable		 1fmlA-6g72N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 5 LEU A 236
HIS A 121
HIS A 326
TYR A 222
ILE A 171
 None
 1.25A 1fmlA-6gupA:
undetectable		 1fmlA-6gupA:
undetectable