SIMILAR PATTERNS OF AMINO ACIDS FOR 1FM6_U_9CRU502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg8 PROTEIN (HEMOGLOBIN)

(Dasyatis akajei) 		PF00042
(Globin) 		5 LEU B  28
ALA B  25
VAL B  93
ILE B  91
LEU B  84
 None
None
HEM  B 142 ( 4.6A)
HEM  B 142 (-4.3A)
HEM  B 142 (-4.6A)
 0.98A 1fm6U-1cg8B:
undetectable		 1fm6U-1cg8B:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 387
ALA A 357
LEU A 383
ALA A 384
ILE A 310
 None
 0.99A 1fm6U-1dabA:
undetectable		 1fm6U-1dabA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		5 ALA M  34
LEU M 455
ALA M 456
VAL M 179
LEU M 124
 None
 0.96A 1fm6U-1dwaM:
undetectable		 1fm6U-1dwaM:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		5 ALA A  34
LEU A  97
ALA A  96
VAL A   5
LEU A 234
 None
 0.91A 1fm6U-1e19A:
undetectable		 1fm6U-1e19A:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 LEU A 366
VAL A 382
CYH A 472
HIS A 475
LEU A 476
 LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
None
LPP  A   1 (-4.2A)
 0.66A 1fm6U-1hg4A:
24.3		 1fm6U-1hg4A:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		6 TRP A 318
VAL A 382
ILE A 385
CYH A 472
HIS A 475
LEU A 476
 None
LPP  A   1 (-4.8A)
None
LPP  A   1 ( 4.2A)
None
LPP  A   1 (-4.2A)
 1.14A 1fm6U-1hg4A:
24.3		 1fm6U-1hg4A:
44.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		5 ALA A  40
LEU A  85
VAL A 157
ILE A 158
LEU A 165
 None
 1.03A 1fm6U-1jeoA:
undetectable		 1fm6U-1jeoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		5 ALA A 182
ALA A 183
ALA A 169
ILE A 200
HIS A 201
 None
 0.85A 1fm6U-1nmoA:
undetectable		 1fm6U-1nmoA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 ARG A 297
LEU A 325
VAL A 341
HIS A 434
LEU A 435
 None
None
EPH  A4000 (-4.9A)
None
EPH  A4000 ( 4.6A)
 0.77A 1fm6U-1r20A:
23.7		 1fm6U-1r20A:
46.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 ARG A 297
VAL A 341
ILE A 344
HIS A 434
LEU A 435
 None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.1A)
None
EPH  A4000 ( 4.6A)
 0.85A 1fm6U-1r20A:
23.7		 1fm6U-1r20A:
46.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		5 ALA A 231
ALA A 230
ALA A  86
VAL A 115
ILE A  36
 None
 1.00A 1fm6U-1s2nA:
undetectable		 1fm6U-1s2nA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 818
ALA A 817
LEU A 746
ALA A 742
ILE A 715
 None
 1.01A 1fm6U-1sojA:
undetectable		 1fm6U-1sojA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ALA A 342
ALA A 343
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
ILE A 416
CYH A 503
HIS A 506
LEU A 507
 MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
None
MEI  A1001 (-4.0A)
None
MEI  A1001 (-4.6A)
 0.65A 1fm6U-1uhlA:
33.7		 1fm6U-1uhlA:
88.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 TRP A 376
VAL A 413
ILE A 416
CYH A 503
HIS A 506
LEU A 507
 None
MEI  A1001 (-4.1A)
None
MEI  A1001 (-4.0A)
None
MEI  A1001 (-4.6A)
 1.20A 1fm6U-1uhlA:
33.7		 1fm6U-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		5 ALA A 283
ALA A 286
ILE A 358
HIS A 272
LEU A 315
 None
 0.94A 1fm6U-1vheA:
undetectable		 1fm6U-1vheA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		6 ALA A 155
ALA A  43
ALA A 141
ILE A 286
HIS A 332
LEU A 336
 None
 1.35A 1fm6U-1x9eA:
undetectable		 1fm6U-1x9eA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		11 ALA A 245
ALA A 246
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
ILE A 319
CYH A 406
HIS A 409
LEU A 410
 9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
None
9CR  A 201 (-3.6A)
9CR  A 201 (-4.8A)
9CR  A 201 ( 4.8A)
 0.33A 1fm6U-1xiuA:
31.7		 1fm6U-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		6 TRP A 279
VAL A 316
ILE A 319
CYH A 406
HIS A 409
LEU A 410
 None
9CR  A 201 (-4.2A)
None
9CR  A 201 (-3.6A)
9CR  A 201 (-4.8A)
9CR  A 201 ( 4.8A)
 0.96A 1fm6U-1xiuA:
31.7		 1fm6U-1xiuA:
81.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
None
9CR  A 801 (-4.7A)
 0.39A 1fm6U-1xlsA:
36.7		 1fm6U-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 TRP A 305
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 None
9CR  A 801 ( 4.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
None
9CR  A 801 (-4.7A)
 1.11A 1fm6U-1xlsA:
36.7		 1fm6U-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 1.00A 1fm6U-1xv9B:
20.2		 1fm6U-1xv9B:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ALA A 146
ALA A 151
LEU A 111
VAL A 123
LEU A  65
 None
 1.03A 1fm6U-2cfmA:
undetectable		 1fm6U-2cfmA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A  57
ALA A  58
ALA A  29
VAL A 163
LEU A 171
 None
 0.84A 1fm6U-2dpnA:
undetectable		 1fm6U-2dpnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		5 ALA A 341
ALA A 346
LEU A 373
VAL A 308
ILE A 304
 None
 1.02A 1fm6U-2euhA:
undetectable		 1fm6U-2euhA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ALA A 166
ALA A 165
VAL A 233
ILE A 245
HIS A  74
 None
PMS  A 601 ( 3.8A)
None
PMS  A 601 (-4.5A)
None
 1.02A 1fm6U-2gkoA:
undetectable		 1fm6U-2gkoA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
ILE A 124
CYH A 211
 None
 0.75A 1fm6U-2gl8A:
26.7		 1fm6U-2gl8A:
85.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2

(Homo sapiens) 		PF00782
(DSPc) 		5 ALA A 418
TRP A 413
LEU A 439
VAL A 390
ILE A 378
 None
 1.00A 1fm6U-2nt2A:
undetectable		 1fm6U-2nt2A:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.74A 1fm6U-2nxxA:
25.1		 1fm6U-2nxxA:
63.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		5 ALA A  64
ALA A  65
LEU A   9
VAL A 136
ILE A 132
 None
 1.03A 1fm6U-2p6wA:
undetectable		 1fm6U-2p6wA:
23.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		6 PHE A 188
ARG A 191
ALA A 202
VAL A 217
ILE A 220
CYH A 307
 None
 0.62A 1fm6U-2q60A:
26.0		 1fm6U-2q60A:
71.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw6 AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		5 ALA A 313
ALA A 305
LEU A 310
ILE A 244
LEU A 279
 None
 1.04A 1fm6U-2qw6A:
undetectable		 1fm6U-2qw6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ALA A 409
ALA A 408
LEU A 381
ILE A 349
LEU A 472
 None
 1.00A 1fm6U-2qykA:
undetectable		 1fm6U-2qykA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		5 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.90A 1fm6U-2vmlA:
undetectable		 1fm6U-2vmlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		6 ALA A 190
ALA A 193
TRP A 134
ALA A 176
ILE A 219
HIS A 201
 None
 1.39A 1fm6U-3ahxA:
undetectable		 1fm6U-3ahxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1a PUTATIVE
OXIDOREDUCTASE

(Magnetospirillum
magnetotacticum) 		PF01408
(GFO_IDH_MocA) 		6 ALA A 113
ALA A 112
ALA A 117
ILE A  74
HIS A  81
LEU A 101
 None
 1.29A 1fm6U-3c1aA:
undetectable		 1fm6U-3c1aA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		5 ALA A 167
ALA A 166
VAL A 234
ILE A 246
HIS A  74
 None
 1.03A 1fm6U-3d43A:
undetectable		 1fm6U-3d43A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.79A 1fm6U-3d8uA:
undetectable		 1fm6U-3d8uA:
25.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		9 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
CYH A 432
LEU A 436
 9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
None
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 1.47A 1fm6U-3dzuA:
32.6		 1fm6U-3dzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		11 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
9CR  A7223 (-4.3A)
9CR  A7223 ( 4.7A)
 0.62A 1fm6U-3dzuA:
32.6		 1fm6U-3dzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 TRP A 305
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 None
9CR  A7223 ( 4.5A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
9CR  A7223 (-4.3A)
9CR  A7223 ( 4.7A)
 1.13A 1fm6U-3dzuA:
32.6		 1fm6U-3dzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		6 TRP A 334
PHE A 342
LEU A 355
ALA A 356
VAL A 371
CYH A 461
 None
 1.08A 1fm6U-3eybA:
27.6		 1fm6U-3eybA:
84.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		7 TRP A 334
PHE A 342
LEU A 355
VAL A 371
ILE A 374
CYH A 461
HIS A 464
 None
 1.08A 1fm6U-3eybA:
27.6		 1fm6U-3eybA:
84.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		5 ALA A   9
PHE A  42
ALA A  49
VAL A  22
ILE A  23
 None
 1.00A 1fm6U-3g23A:
undetectable		 1fm6U-3g23A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH

(Bacillus
subtilis) 		PF00378
(ECH_1) 		5 ALA A 125
VAL A  11
ILE A   9
CYH A  39
LEU A  43
 None
 0.94A 1fm6U-3hp0A:
undetectable		 1fm6U-3hp0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		5 ALA A 160
ALA A 161
LEU A  80
ILE A  15
LEU A  32
 None
None
None
FAD  A 371 (-4.1A)
None
 1.01A 1fm6U-3if9A:
undetectable		 1fm6U-3if9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 5 LEU D 160
ALA D 161
VAL D 193
ILE D  19
LEU D 186
 None
 1.02A 1fm6U-3jazD:
undetectable		 1fm6U-3jazD:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ALA A1284
PHE A1280
LEU A1349
ILE A1325
LEU A1272
 None
 1.04A 1fm6U-3jb9A:
undetectable		 1fm6U-3jb9A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 ALA A  89
ALA A  90
LEU A 383
ALA A 384
HIS A 162
 None
 1.03A 1fm6U-3kehA:
undetectable		 1fm6U-3kehA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lb5 HIT-LIKE PROTEIN
INVOLVED IN
CELL-CYCLE
REGULATION

(Bartonella
henselae) 		PF01230
(HIT) 		5 ALA A  76
LEU A 140
ALA A 139
VAL A  30
ILE A  31
 None
 0.96A 1fm6U-3lb5A:
undetectable		 1fm6U-3lb5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 ALA A 262
LEU A 180
VAL A 360
ILE A 362
LEU A 370
 None
 0.99A 1fm6U-3mcaA:
undetectable		 1fm6U-3mcaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		5 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.80A 1fm6U-3msuA:
undetectable		 1fm6U-3msuA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 ALA A  77
ALA A  76
ALA A 232
HIS A 347
LEU A 348
 None
 0.88A 1fm6U-3qqvA:
undetectable		 1fm6U-3qqvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		5 ALA A 174
ALA A 163
VAL A 101
ILE A 103
LEU A 130
 None
 1.03A 1fm6U-3sggA:
undetectable		 1fm6U-3sggA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 ALA A 231
ALA A 232
LEU A 298
ALA A 297
LEU A 274
 None
 0.91A 1fm6U-3upnA:
undetectable		 1fm6U-3upnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE

(Coxiella
burnetii) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  91
LEU A  63
ALA A  64
ILE A 110
LEU A 101
 None
 1.00A 1fm6U-3uwcA:
undetectable		 1fm6U-3uwcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		5 ALA A  94
LEU A 143
ALA A 142
VAL A 205
ILE A 203
 None
 1.01A 1fm6U-3visA:
undetectable		 1fm6U-3visA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		5 ALA A 178
ALA A 177
PHE A  87
ALA A  86
ILE A 332
 None
 1.01A 1fm6U-3wc3A:
undetectable		 1fm6U-3wc3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		5 ALA A 178
ALA A 177
PHE A  87
ILE A 332
LEU A 280
 None
 0.93A 1fm6U-3wc3A:
undetectable		 1fm6U-3wc3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj0 ACETYLTRANSFERASE

(Oceanicola
granulosus) 		PF00583
(Acetyltransf_1) 		5 ALA A  47
LEU A  18
ILE A   7
HIS A 154
LEU A 155
 None
 0.99A 1fm6U-3zj0A:
undetectable		 1fm6U-3zj0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zja SL3965

(Streptomyces
lividans) 		PF04314
(PCuAC) 		5 ALA A  57
ALA A  58
VAL A 113
ILE A 111
LEU A 147
 None
 0.87A 1fm6U-3zjaA:
undetectable		 1fm6U-3zjaA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		5 ALA A 132
ALA A 130
ILE A 138
CYH A 328
LEU A 332
 None
 1.02A 1fm6U-4czeA:
undetectable		 1fm6U-4czeA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00248
(Aldo_ket_red) 		5 ALA A 266
LEU A 267
VAL A 212
ILE A 247
LEU A 216
 None
 1.02A 1fm6U-4exbA:
undetectable		 1fm6U-4exbA:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 11 ALA D 271
ALA D 272
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
ILE D 345
CYH D 432
HIS D 435
LEU D 436
 None
 0.60A 1fm6U-4j5xD:
32.4		 1fm6U-4j5xD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 PHE D 313
ARG D 316
ILE D 345
CYH D 432
HIS D 435
LEU D 433
 None
 1.34A 1fm6U-4j5xD:
32.4		 1fm6U-4j5xD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 6 TRP D 305
VAL D 342
ILE D 345
CYH D 432
HIS D 435
LEU D 436
 None
 1.12A 1fm6U-4j5xD:
32.4		 1fm6U-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfc ENOYL-COA HYDRATASE

(Polaromonas sp.
JS666) 		PF00378
(ECH_1) 		5 ALA A 110
PHE A  60
ALA A 108
ILE A  94
LEU A  87
 None
 0.98A 1fm6U-4jfcA:
undetectable		 1fm6U-4jfcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.91A 1fm6U-4k70A:
undetectable		 1fm6U-4k70A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ALA A 352
PHE A 285
ALA A 408
VAL A 332
ILE A 320
 None
 1.01A 1fm6U-4lnfA:
undetectable		 1fm6U-4lnfA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m87 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Neisseria
meningitidis) 		PF13561
(adh_short_C2) 		5 ALA A 130
ALA A 131
ILE A 171
CYH A 185
LEU A 178
 None
 1.04A 1fm6U-4m87A:
undetectable		 1fm6U-4m87A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		5 ALA A 309
ALA A 308
LEU A  96
ALA A  95
LEU A 133
 None
 1.04A 1fm6U-4o5aA:
undetectable		 1fm6U-4o5aA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 ALA A 200
LEU A 262
ALA A 212
VAL A 430
ILE A 443
HIS A 441
 None
 1.48A 1fm6U-4oqjA:
undetectable		 1fm6U-4oqjA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.74A 1fm6U-4qpnA:
undetectable		 1fm6U-4qpnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		6 ALA A 200
LEU A 262
ALA A 212
VAL A 427
ILE A 440
HIS A 438
 None
 1.49A 1fm6U-4wkyA:
undetectable		 1fm6U-4wkyA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.11A 1fm6U-4xboA:
undetectable		 1fm6U-4xboA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ALA A 322
ALA A 321
LEU A 348
ALA A 347
ILE A 398
 None
 0.93A 1fm6U-4xg0A:
undetectable		 1fm6U-4xg0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 ALA A 169
ALA A 168
TRP A 323
LEU A 181
ALA A 178
 None
 1.04A 1fm6U-4xniA:
undetectable		 1fm6U-4xniA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31
VIRION EGRESS
PROTEIN UL34

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31)
PF04541
(Herpes_U34) 		5 ALA B  67
PHE B  65
ARG A  22
LEU B  68
ALA B  69
 None
 1.03A 1fm6U-4zxsB:
undetectable		 1fm6U-4zxsB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		5 ALA A 283
LEU A 280
ALA A 279
VAL A 385
ILE A 374
 None
 0.91A 1fm6U-5b3jA:
undetectable		 1fm6U-5b3jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 ALA A  25
LEU A 186
VAL A  70
ILE A  68
LEU A  52
 None
 1.01A 1fm6U-5b48A:
undetectable		 1fm6U-5b48A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
 None
 0.70A 1fm6U-5bt1A:
undetectable		 1fm6U-5bt1A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		5 ALA A  66
PHE A 104
LEU A 107
ALA A 106
ILE A 138
 SAH  A 400 (-3.3A)
None
None
None
None
 0.89A 1fm6U-5f2oA:
undetectable		 1fm6U-5f2oA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 ALA A 168
ALA A 167
VAL A 235
ILE A 247
HIS A  75
 None
 1.04A 1fm6U-5ffnA:
undetectable		 1fm6U-5ffnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(uncultured
marine
bacterium) 		PF03480
(DctP) 		5 ALA A 141
LEU A 267
ALA A 268
VAL A  62
ILE A  64
 None
PEG  A 402 ( 4.8A)
None
None
None
 0.83A 1fm6U-5i5pA:
undetectable		 1fm6U-5i5pA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.) 		PF08028
(Acyl-CoA_dh_2) 		5 ALA A 310
ALA A 311
LEU A 317
ALA A 316
VAL A 242
 None
 0.99A 1fm6U-5mr6A:
undetectable		 1fm6U-5mr6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 1.00A 1fm6U-5mzyA:
undetectable		 1fm6U-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 ALA A 514
ALA A 539
ALA A 510
VAL A 640
LEU A 608
 None
 0.97A 1fm6U-5t8vA:
undetectable		 1fm6U-5t8vA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 302
PHE A 356
VAL A 370
HIS A 475
LEU A 476
 EST  A 601 ( 3.9A)
EST  A 601 ( 4.9A)
None
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 1.02A 1fm6U-5toaA:
23.3		 1fm6U-5toaA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 7 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.24A 1fm6U-5uanA:
33.0		 1fm6U-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 11 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.55A 1fm6U-5uanA:
33.0		 1fm6U-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 6 TRP A 305
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 None
None
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 1.16A 1fm6U-5uanA:
33.0		 1fm6U-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 7 ALA A 119
ALA A 118
LEU A  92
ALA A  88
VAL A  55
ILE A  61
LEU A 182
 None
 1.18A 1fm6U-5vydA:
undetectable		 1fm6U-5vydA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		5 ALA A 397
LEU A 156
ALA A 155
ILE A 235
LEU A 358
 None
 0.78A 1fm6U-5xezA:
undetectable		 1fm6U-5xezA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN

(Citrobacter sp.
MGH106) 		no annotation 5 ALA S 127
ALA S 129
VAL S  80
ILE S 117
CYH S  25
 None
None
None
None
SF4  S 403 ( 2.1A)
 1.00A 1fm6U-5xvdS:
undetectable		 1fm6U-5xvdS:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 213
ALA A 212
LEU A 254
ILE A 203
LEU A 200
 None
 0.92A 1fm6U-6ayvA:
undetectable		 1fm6U-6ayvA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 ALA A  20
ALA A  21
ALA A 329
VAL A 126
ILE A 137
 None
 0.96A 1fm6U-6cmzA:
undetectable		 1fm6U-6cmzA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 5 ALA A 304
ALA A 379
VAL A 164
ILE A 161
CYH A 247
 SO4  A 503 ( 4.5A)
None
None
None
None
 1.00A 1fm6U-6cxdA:
undetectable		 1fm6U-6cxdA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 5 ALA A 132
ALA A 133
LEU A 267
ALA A 266
ILE A 180
 None
 1.00A 1fm6U-6d95A:
undetectable		 1fm6U-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eih 14-3-3 PROTEIN
EPSILON

(Homo sapiens) 		no annotation 5 ALA A 145
ALA A 144
ILE A  53
CYH A  97
LEU A 101
 None
 1.01A 1fm6U-6eihA:
undetectable		 1fm6U-6eihA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN

(Escherichia
coli) 		no annotation 5 ALA S 127
ALA S 129
VAL S  80
ILE S 117
CYH S  25
 None
None
None
None
SF4  S 303 (-2.2A)
 1.00A 1fm6U-6en9S:
undetectable		 1fm6U-6en9S:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		no annotation 5 ALA A 173
ALA A 170
LEU A 177
ALA A 175
HIS A 188
 None
None
None
None
CD  A 403 ( 3.6A)
 0.96A 1fm6U-6fv4A:
undetectable		 1fm6U-6fv4A:
16.67