SIMILAR PATTERNS OF AMINO ACIDS FOR 1FM6_D_BRLD503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 GLY A 682
SER A 738
HIS A 352
LEU A 170
LEU A 736
 None
 1.11A 1fm6D-1c7tA:
undetectable		 1fm6D-1c7tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		5 GLY A 102
HIS A 119
LEU A  70
LEU A 128
LEU A 137
 None
 1.37A 1fm6D-1cbkA:
undetectable		 1fm6D-1cbkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 CYH L 492
HIS L 498
HIS L  77
LEU L 428
LEU L 449
 NI  L 500 (-2.4A)
FE2  L 501 (-3.5A)
FCO  L 499 (-3.9A)
FCO  L 499 (-3.5A)
None
 1.30A 1fm6D-1cc1L:
0.0		 1fm6D-1cc1L:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
6

(Homo sapiens) 		PF00581
(Rhodanese) 		5 GLY A 126
CYH A 127
LEU A  97
LEU A 119
TYR A 131
 None
 1.39A 1fm6D-1hzmA:
undetectable		 1fm6D-1hzmA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLY A 174
HIS A 236
MET A 184
LEU A 384
TYR A 356
 None
 1.20A 1fm6D-1kczA:
undetectable		 1fm6D-1kczA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF08992
(QH-AmDH_gamma)
no annotation 		5 GLY B  33
SER B  55
LEU B  13
LEU B 327
LEU C  51
 None
None
None
TRW  C  43 ( 4.2A)
None
 1.26A 1fm6D-1pbyB:
undetectable		 1fm6D-1pbyB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 158
CYH A 159
SER A 165
LEU A 243
TYR A 207
 M6T  A 681 (-3.5A)
None
None
None
None
 1.24A 1fm6D-1tkcA:
0.4		 1fm6D-1tkcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		5 GLY A 507
HIS A 803
TYR A 610
LEU A 387
LEU A 517
 None
 1.29A 1fm6D-2hcsA:
0.0		 1fm6D-2hcsA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 456
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.6A)
 1.42A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.54A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
SER A 280
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.80A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 GLY A  81
SER A 342
LEU A 316
MET A 315
LEU A 430
 None
 1.26A 1fm6D-2radA:
0.0		 1fm6D-2radA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 GLY A 360
SER A 304
LEU A 789
MET A 788
LEU A 807
 None
 1.38A 1fm6D-2vcaA:
undetectable		 1fm6D-2vcaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 GLY A 107
SER A 137
LEU A 270
LEU A 257
TYR A 253
 None
 1.20A 1fm6D-2vk9A:
undetectable		 1fm6D-2vk9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 GLY A 265
SER A  40
LEU A  50
LEU A  38
TYR A  51
 None
 1.30A 1fm6D-2vp1A:
undetectable		 1fm6D-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 SER A 264
TYR A  44
LEU A  59
HIS A  43
TYR A 169
 None
FE  A1347 (-4.1A)
None
FE  A1347 (-3.3A)
FE  A1347 (-4.3A)
 1.44A 1fm6D-2vp1A:
undetectable		 1fm6D-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 HIS A  87
TYR A 104
LEU A 178
HIS A 121
LEU A 117
 None
 1.29A 1fm6D-2vrcA:
undetectable		 1fm6D-2vrcA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 GLY A 481
CYH A 482
LEU A 474
LEU A 401
LEU A 391
 None
 1.23A 1fm6D-2wc7A:
undetectable		 1fm6D-2wc7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 GLY B 200
CYH B 202
SER B 206
LEU B 321
TYR B 325
 None
 0.93A 1fm6D-3aqcB:
undetectable		 1fm6D-3aqcB:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 GLY A 284
CYH A 285
SER A 289
HIS A 323
TYR A 327
MET A 348
LEU A 353
MET A 364
HIS A 449
LEU A 453
LEU A 469
TYR A 473
 MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 ( 4.0A)
MC5  A   1 (-4.7A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.48A 1fm6D-3b0qA:
39.8		 1fm6D-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 284
LEU A 356
HIS A 449
LEU A 453
LEU A 469
TYR A 473
 MC5  A   1 ( 4.5A)
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 1.37A 1fm6D-3b0qA:
39.8		 1fm6D-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  50
CYH A  49
HIS A 132
LEU A 244
LEU A 174
 None
 1.32A 1fm6D-3bn1A:
undetectable		 1fm6D-3bn1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		5 GLY B 112
TYR B 188
LEU B  75
LEU B 176
LEU B 141
 None
 1.28A 1fm6D-3cfiB:
undetectable		 1fm6D-3cfiB:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
HIS A 323
LEU A 353
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.66A 1fm6D-3d5fA:
36.5		 1fm6D-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 285
HIS A 323
LEU A 356
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 1.25A 1fm6D-3d5fA:
36.5		 1fm6D-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		5 GLY A 232
SER A  48
HIS A  52
TYR A 248
LEU A 256
 FAD  A 500 ( 4.6A)
FAD  A 500 ( 2.9A)
TLA  A 999 ( 3.7A)
TLA  A 999 (-4.7A)
None
 1.32A 1fm6D-3dmeA:
undetectable		 1fm6D-3dmeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap) 		5 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.32A 1fm6D-3dwdA:
undetectable		 1fm6D-3dwdA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 GLY D 284
MET D 348
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 4.7A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.68A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 GLY D 284
SER D 289
MET D 348
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
None
None
 0.93A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 SER D 289
TYR D 327
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.8A)
None
None
None
 1.12A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 TYR D 327
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 None
None
PLB  D 701 ( 4.8A)
None
None
None
 0.89A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		5 GLY A 441
SER A 236
MET A 433
LEU A 289
LEU A 204
 None
 1.36A 1fm6D-3eu8A:
undetectable		 1fm6D-3eu8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 475
HIS A 443
LEU A 446
LEU A 424
TYR A 423
 None
 1.36A 1fm6D-3h11A:
undetectable		 1fm6D-3h11A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k67 PUTATIVE DEHYDRATASE
AF1124

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		5 GLY A 119
CYH A  49
TYR A  19
LEU A  91
LEU A  87
 None
 1.24A 1fm6D-3k67A:
undetectable		 1fm6D-3k67A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 5 GLY A 224
SER A 230
LEU A 348
LEU A 330
LEU A 307
 None
 1.32A 1fm6D-3ly9A:
undetectable		 1fm6D-3ly9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		5 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.40A 1fm6D-3o47A:
undetectable		 1fm6D-3o47A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		5 HIS A 291
MET A 179
LEU A 208
MET A 265
LEU A 318
 None
 1.40A 1fm6D-3obkA:
undetectable		 1fm6D-3obkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		5 GLY A  70
SER A  68
LEU A 163
HIS A  32
LEU A  13
 NA  A 276 (-3.4A)
None
None
None
None
 1.41A 1fm6D-3qm1A:
undetectable		 1fm6D-3qm1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		5 GLY A 472
MET A 407
LEU A 411
LEU A 333
TYR A 329
 None
 1.48A 1fm6D-3u7vA:
undetectable		 1fm6D-3u7vA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 GLY A 956
LEU A 819
MET A 897
LEU A 920
LEU A 912
 None
 1.16A 1fm6D-3ummA:
undetectable		 1fm6D-3ummA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 GLY A 288
MET A  95
LEU A 104
LEU A 159
TYR A 261
 None
None
NHE  A 407 ( 4.1A)
None
None
 1.40A 1fm6D-3wq1A:
undetectable		 1fm6D-3wq1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 266
CYH A 267
LEU A 111
LEU A 201
LEU A 218
 None
 1.05A 1fm6D-4aguA:
undetectable		 1fm6D-4aguA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY A 159
SER A 162
LEU A 132
LEU A  58
TYR A 154
 PO4  A 401 ( 3.8A)
None
None
None
None
 1.40A 1fm6D-4d8uA:
undetectable		 1fm6D-4d8uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLY A 362
SER A 332
HIS A 280
LEU A 343
LEU A 212
 None
 1.47A 1fm6D-4efcA:
1.3		 1fm6D-4efcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 HIS A  60
LEU A 417
MET A 412
HIS A 403
LEU A  55
 None
 1.45A 1fm6D-4f0sA:
undetectable		 1fm6D-4f0sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz2 TRNA INTRON
ENDONUCLEASE

(Candidatus
Micrarchaeum
acidiphilum) 		PF01974
(tRNA_int_endo) 		5 GLY A 220
LEU A 154
LEU A 256
LEU A 372
TYR A 379
 None
 1.02A 1fm6D-4fz2A:
undetectable		 1fm6D-4fz2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh5 PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		5 GLY A  75
HIS A  35
LEU A 134
HIS A  42
LEU A  29
 None
 1.33A 1fm6D-4hh5A:
undetectable		 1fm6D-4hh5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 255
LEU A  67
MET A  71
LEU A   6
LEU A 263
 None
 1.05A 1fm6D-4itxA:
undetectable		 1fm6D-4itxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 GLY A 407
TYR A 474
MET A 568
LEU A 414
LEU A 391
 None
 1.48A 1fm6D-4l68A:
undetectable		 1fm6D-4l68A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLY A 373
SER A 343
HIS A 291
LEU A 354
LEU A 223
 None
 1.49A 1fm6D-4mx2A:
undetectable		 1fm6D-4mx2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		5 GLY A 451
SER A 246
MET A 443
LEU A 299
LEU A 214
 None
 1.35A 1fm6D-4qt9A:
undetectable		 1fm6D-4qt9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 GLY A 162
HIS A 389
LEU A 337
LEU A 106
TYR A 109
 None
 1.33A 1fm6D-4txaA:
undetectable		 1fm6D-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 HIS A 389
LEU A 337
LEU A 129
LEU A 106
TYR A 109
 None
 1.30A 1fm6D-4txaA:
undetectable		 1fm6D-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 GLY A1178
CYH A1179
LEU A1537
MET A1625
TYR A1248
 None
 1.47A 1fm6D-4u48A:
undetectable		 1fm6D-4u48A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 CYH A 189
SER A 187
LEU A 145
LEU A 139
TYR A 141
 None
SO4  A 501 ( 4.6A)
None
None
None
 0.97A 1fm6D-4xguA:
undetectable		 1fm6D-4xguA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 GLY A1186
CYH A1187
LEU A1546
MET A1634
TYR A1256
 None
 1.45A 1fm6D-4ziuA:
undetectable		 1fm6D-4ziuA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 GLY A 179
SER A 130
LEU A 218
LEU A 114
TYR A 299
 None
 1.37A 1fm6D-4zktA:
undetectable		 1fm6D-4zktA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR

(Streptomyces
coelicolor) 		PF00392
(GntR)
PF07702
(UTRA) 		5 SER A 223
LEU A 125
LEU A 176
LEU A 188
TYR A 177
 None
 1.29A 1fm6D-4zs8A:
undetectable		 1fm6D-4zs8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR

(Streptomyces
coelicolor) 		PF07702
(UTRA) 		5 SER A 223
LEU A 125
LEU A 176
LEU A 188
TYR A 177
 None
 1.28A 1fm6D-4zsbA:
undetectable		 1fm6D-4zsbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		5 GLY A 193
SER A 199
LEU A 229
MET A 226
LEU A  77
 None
None
7E8  A 404 ( 3.2A)
7E8  A 404 (-4.0A)
None
 1.14A 1fm6D-5bz3A:
undetectable		 1fm6D-5bz3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A 162
CYH A 163
LEU A  51
LEU A 335
TYR A 259
 None
 1.19A 1fm6D-5cdeA:
undetectable		 1fm6D-5cdeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 GLY A 348
LEU A 248
MET A 247
LEU A 379
LEU A 206
 None
 1.46A 1fm6D-5e4rA:
undetectable		 1fm6D-5e4rA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 135
SER A  78
HIS A 354
LEU A 138
LEU A 192
 None
 1.08A 1fm6D-5ei0A:
undetectable		 1fm6D-5ei0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		5 GLY A 429
SER A 222
MET A 421
LEU A 277
LEU A 190
 None
 1.37A 1fm6D-5gzhA:
undetectable		 1fm6D-5gzhA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		6 HIS A 267
TYR A 265
LEU A 312
LEU A 215
LEU A 180
TYR A 217
 None
 1.42A 1fm6D-5hy7A:
undetectable		 1fm6D-5hy7A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 156
CYH A 157
SER A 163
LEU A 241
TYR A 205
 TPP  A 701 (-3.5A)
None
None
None
None
 1.29A 1fm6D-5i51A:
undetectable		 1fm6D-5i51A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 SER A  61
HIS A 862
LEU A 608
MET A 528
LEU A  66
 None
 1.47A 1fm6D-5nd1A:
undetectable		 1fm6D-5nd1A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 209
CYH A 210
SER A 216
LEU A 294
TYR A 258
 TPP  A 801 (-3.5A)
None
None
None
None
 1.28A 1fm6D-5nd5A:
undetectable		 1fm6D-5nd5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 GLY A 313
LEU A 338
HIS A 450
LEU A 486
TYR A 482
 None
 1.46A 1fm6D-5t81A:
undetectable		 1fm6D-5t81A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  48
CYH A  47
HIS A 130
LEU A 241
LEU A 172
 EDO  A 403 ( 4.5A)
None
None
None
None
 1.42A 1fm6D-5u24A:
undetectable		 1fm6D-5u24A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhy ZV67 FAB CHAIN 2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  65
SER H 112
TYR H  90
LEU H  69
MET H  80
 None
 1.43A 1fm6D-5uhyH:
undetectable		 1fm6D-5uhyH:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 5 GLY A 120
LEU A 112
LEU A 208
LEU A  22
TYR A 414
 None
 1.39A 1fm6D-5wm4A:
undetectable		 1fm6D-5wm4A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.49A 1fm6D-5yo8A:
undetectable		 1fm6D-5yo8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 GLY A 187
LEU A 183
LEU A 231
LEU A 216
TYR A 227
 None
 1.28A 1fm6D-6bz0A:
undetectable		 1fm6D-6bz0A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv6 3-DEHYDROQUINATE
DEHYDRATASE

(Paraburkholderia
phymatum) 		no annotation 5 HIS A   8
LEU A  93
LEU A 100
LEU A  35
TYR A 133
 None
 1.30A 1fm6D-6cv6A:
undetectable		 1fm6D-6cv6A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv6 3-DEHYDROQUINATE
DEHYDRATASE

(Paraburkholderia
phymatum) 		no annotation 5 SER A  48
HIS A   8
LEU A  93
LEU A 100
LEU A  35
 None
 1.17A 1fm6D-6cv6A:
undetectable		 1fm6D-6cv6A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 5 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.38A 1fm6D-6d0sA:
undetectable		 1fm6D-6d0sA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 5 GLY B 421
SER B 269
MET B 321
LEU B  92
MET B  95
 None
 1.50A 1fm6D-6f5oB:
undetectable		 1fm6D-6f5oB:
16.07