SIMILAR PATTERNS OF AMINO ACIDS FOR 1FM6_D_BRLD503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 GLY A 682
SER A 738
HIS A 352
LEU A 170
LEU A 736
 None
 1.11A 1fm6D-1c7tA:
undetectable		 1fm6D-1c7tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		5 GLY A 102
HIS A 119
LEU A  70
LEU A 128
LEU A 137
 None
 1.37A 1fm6D-1cbkA:
undetectable		 1fm6D-1cbkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 CYH L 492
HIS L 498
HIS L  77
LEU L 428
LEU L 449
 NI  L 500 (-2.4A)
FE2  L 501 (-3.5A)
FCO  L 499 (-3.9A)
FCO  L 499 (-3.5A)
None
 1.30A 1fm6D-1cc1L:
0.0		 1fm6D-1cc1L:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzm DUAL SPECIFICITY
PROTEIN PHOSPHATASE
6

(Homo sapiens) 		PF00581
(Rhodanese) 		5 GLY A 126
CYH A 127
LEU A  97
LEU A 119
TYR A 131
 None
 1.39A 1fm6D-1hzmA:
undetectable		 1fm6D-1hzmA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLY A 174
HIS A 236
MET A 184
LEU A 384
TYR A 356
 None
 1.20A 1fm6D-1kczA:
undetectable		 1fm6D-1kczA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
9 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF08992
(QH-AmDH_gamma)
no annotation 		5 GLY B  33
SER B  55
LEU B  13
LEU B 327
LEU C  51
 None
None
None
TRW  C  43 ( 4.2A)
None
 1.26A 1fm6D-1pbyB:
undetectable		 1fm6D-1pbyB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 158
CYH A 159
SER A 165
LEU A 243
TYR A 207
 M6T  A 681 (-3.5A)
None
None
None
None
 1.24A 1fm6D-1tkcA:
0.4		 1fm6D-1tkcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		5 GLY A 507
HIS A 803
TYR A 610
LEU A 387
LEU A 517
 None
 1.29A 1fm6D-2hcsA:
0.0		 1fm6D-2hcsA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 456
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 4.8A)
735  A 469 (-4.6A)
 1.42A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
LEU A 344
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.54A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
SER A 280
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.80A 1fm6D-2p54A:
37.7		 1fm6D-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 GLY A  81
SER A 342
LEU A 316
MET A 315
LEU A 430
 None
 1.26A 1fm6D-2radA:
0.0		 1fm6D-2radA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 GLY A 360
SER A 304
LEU A 789
MET A 788
LEU A 807
 None
 1.38A 1fm6D-2vcaA:
undetectable		 1fm6D-2vcaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 GLY A 107
SER A 137
LEU A 270
LEU A 257
TYR A 253
 None
 1.20A 1fm6D-2vk9A:
undetectable		 1fm6D-2vk9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 GLY A 265
SER A  40
LEU A  50
LEU A  38
TYR A  51
 None
 1.30A 1fm6D-2vp1A:
undetectable		 1fm6D-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 SER A 264
TYR A  44
LEU A  59
HIS A  43
TYR A 169
 None
FE  A1347 (-4.1A)
None
FE  A1347 (-3.3A)
FE  A1347 (-4.3A)
 1.44A 1fm6D-2vp1A:
undetectable		 1fm6D-2vp1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 HIS A  87
TYR A 104
LEU A 178
HIS A 121
LEU A 117
 None
 1.29A 1fm6D-2vrcA:
undetectable		 1fm6D-2vrcA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 GLY A 481
CYH A 482
LEU A 474
LEU A 401
LEU A 391
 None
 1.23A 1fm6D-2wc7A:
undetectable		 1fm6D-2wc7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 GLY B 200
CYH B 202
SER B 206
LEU B 321
TYR B 325
 None
 0.93A 1fm6D-3aqcB:
undetectable		 1fm6D-3aqcB:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 GLY A 284
CYH A 285
SER A 289
HIS A 323
TYR A 327
MET A 348
LEU A 353
MET A 364
HIS A 449
LEU A 453
LEU A 469
TYR A 473
 MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 ( 4.0A)
MC5  A   1 (-4.7A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.48A 1fm6D-3b0qA:
39.8		 1fm6D-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 284
LEU A 356
HIS A 449
LEU A 453
LEU A 469
TYR A 473
 MC5  A   1 ( 4.5A)
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 1.37A 1fm6D-3b0qA:
39.8		 1fm6D-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  50
CYH A  49
HIS A 132
LEU A 244
LEU A 174
 None
 1.32A 1fm6D-3bn1A:
undetectable		 1fm6D-3bn1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		5 GLY B 112
TYR B 188
LEU B  75
LEU B 176
LEU B 141
 None
 1.28A 1fm6D-3cfiB:
undetectable		 1fm6D-3cfiB:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
HIS A 323
LEU A 353
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.66A 1fm6D-3d5fA:
36.5		 1fm6D-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 285
HIS A 323
LEU A 356
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 1.25A 1fm6D-3d5fA:
36.5		 1fm6D-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF01266
(DAO) 		5 GLY A 232
SER A  48
HIS A  52
TYR A 248
LEU A 256
 FAD  A 500 ( 4.6A)
FAD  A 500 ( 2.9A)
TLA  A 999 ( 3.7A)
TLA  A 999 (-4.7A)
None
 1.32A 1fm6D-3dmeA:
undetectable		 1fm6D-3dmeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap) 		5 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.32A 1fm6D-3dwdA:
undetectable		 1fm6D-3dwdA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 GLY D 284
MET D 348
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 4.7A)
None
PLB  D 701 ( 4.8A)
None
None
None
 0.68A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 GLY D 284
SER D 289
MET D 348
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
None
None
 0.93A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 SER D 289
TYR D 327
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.8A)
None
None
None
 1.12A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 TYR D 327
LEU D 353
MET D 364
HIS D 449
LEU D 469
TYR D 473
 None
None
PLB  D 701 ( 4.8A)
None
None
None
 0.89A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		5 GLY A 441
SER A 236
MET A 433
LEU A 289
LEU A 204
 None
 1.36A 1fm6D-3eu8A:
undetectable		 1fm6D-3eu8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h11 CASP8 AND FADD-LIKE
APOPTOSIS REGULATOR

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 475
HIS A 443
LEU A 446
LEU A 424
TYR A 423
 None
 1.36A 1fm6D-3h11A:
undetectable		 1fm6D-3h11A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k67 PUTATIVE DEHYDRATASE
AF1124

(Archaeoglobus
fulgidus) 		PF01575
(MaoC_dehydratas) 		5 GLY A 119
CYH A  49
TYR A  19
LEU A  91
LEU A  87
 None
 1.24A 1fm6D-3k67A:
undetectable		 1fm6D-3k67A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly9 TRANSCRIPTIONAL
ACTIVATOR CADC

(Escherichia
coli) 		no annotation 5 GLY A 224
SER A 230
LEU A 348
LEU A 330
LEU A 307
 None
 1.32A 1fm6D-3ly9A:
undetectable		 1fm6D-3ly9A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		5 GLY A  26
CYH A  22
HIS A  49
LEU A  99
TYR A 103
 None
ZN  A 501 (-2.3A)
None
None
None
 1.40A 1fm6D-3o47A:
undetectable		 1fm6D-3o47A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		5 HIS A 291
MET A 179
LEU A 208
MET A 265
LEU A 318
 None
 1.40A 1fm6D-3obkA:
undetectable		 1fm6D-3obkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		5 GLY A  70
SER A  68
LEU A 163
HIS A  32
LEU A  13
 NA  A 276 (-3.4A)
None
None
None
None
 1.41A 1fm6D-3qm1A:
undetectable		 1fm6D-3qm1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		5 GLY A 472
MET A 407
LEU A 411
LEU A 333
TYR A 329
 None
 1.48A 1fm6D-3u7vA:
undetectable		 1fm6D-3u7vA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 GLY A 956
LEU A 819
MET A 897
LEU A 920
LEU A 912
 None
 1.16A 1fm6D-3ummA:
undetectable		 1fm6D-3ummA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 GLY A 288
MET A  95
LEU A 104
LEU A 159
TYR A 261
 None
None
NHE  A 407 ( 4.1A)
None
None
 1.40A 1fm6D-3wq1A:
undetectable		 1fm6D-3wq1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 266
CYH A 267
LEU A 111
LEU A 201
LEU A 218
 None
 1.05A 1fm6D-4aguA:
undetectable		 1fm6D-4aguA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8u D-CYSTEINE
DESULFHYDRASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY A 159
SER A 162
LEU A 132
LEU A  58
TYR A 154
 PO4  A 401 ( 3.8A)
None
None
None
None
 1.40A 1fm6D-4d8uA:
undetectable		 1fm6D-4d8uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLY A 362
SER A 332
HIS A 280
LEU A 343
LEU A 212
 None
 1.47A 1fm6D-4efcA:
1.3		 1fm6D-4efcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 HIS A  60
LEU A 417
MET A 412
HIS A 403
LEU A  55
 None
 1.45A 1fm6D-4f0sA:
undetectable		 1fm6D-4f0sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz2 TRNA INTRON
ENDONUCLEASE

(Candidatus
Micrarchaeum
acidiphilum) 		PF01974
(tRNA_int_endo) 		5 GLY A 220
LEU A 154
LEU A 256
LEU A 372
TYR A 379
 None
 1.02A 1fm6D-4fz2A:
undetectable		 1fm6D-4fz2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh5 PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		5 GLY A  75
HIS A  35
LEU A 134
HIS A  42
LEU A  29
 None
 1.33A 1fm6D-4hh5A:
undetectable		 1fm6D-4hh5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 255
LEU A  67
MET A  71
LEU A   6
LEU A 263
 None
 1.05A 1fm6D-4itxA:
undetectable		 1fm6D-4itxA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 GLY A 407
TYR A 474
MET A 568
LEU A 414
LEU A 391
 None
 1.48A 1fm6D-4l68A:
undetectable		 1fm6D-4l68A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 GLY A 373
SER A 343
HIS A 291
LEU A 354
LEU A 223
 None
 1.49A 1fm6D-4mx2A:
undetectable		 1fm6D-4mx2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		5 GLY A 451
SER A 246
MET A 443
LEU A 299
LEU A 214
 None
 1.35A 1fm6D-4qt9A:
undetectable		 1fm6D-4qt9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 GLY A 162
HIS A 389
LEU A 337
LEU A 106
TYR A 109
 None
 1.33A 1fm6D-4txaA:
undetectable		 1fm6D-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 HIS A 389
LEU A 337
LEU A 129
LEU A 106
TYR A 109
 None
 1.30A 1fm6D-4txaA:
undetectable		 1fm6D-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 GLY A1178
CYH A1179
LEU A1537
MET A1625
TYR A1248
 None
 1.47A 1fm6D-4u48A:
undetectable		 1fm6D-4u48A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 CYH A 189
SER A 187
LEU A 145
LEU A 139
TYR A 141
 None
SO4  A 501 ( 4.6A)
None
None
None
 0.97A 1fm6D-4xguA:
undetectable		 1fm6D-4xguA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF07678
(A2M_comp) 		5 GLY A1186
CYH A1187
LEU A1546
MET A1634
TYR A1256
 None
 1.45A 1fm6D-4ziuA:
undetectable		 1fm6D-4ziuA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 GLY A 179
SER A 130
LEU A 218
LEU A 114
TYR A 299
 None
 1.37A 1fm6D-4zktA:
undetectable		 1fm6D-4zktA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs8 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR

(Streptomyces
coelicolor) 		PF00392
(GntR)
PF07702
(UTRA) 		5 SER A 223
LEU A 125
LEU A 176
LEU A 188
TYR A 177
 None
 1.29A 1fm6D-4zs8A:
undetectable		 1fm6D-4zs8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsb HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR DASR

(Streptomyces
coelicolor) 		PF07702
(UTRA) 		5 SER A 223
LEU A 125
LEU A 176
LEU A 188
TYR A 177
 None
 1.28A 1fm6D-4zsbA:
undetectable		 1fm6D-4zsbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		5 GLY A 193
SER A 199
LEU A 229
MET A 226
LEU A  77
 None
None
7E8  A 404 ( 3.2A)
7E8  A 404 (-4.0A)
None
 1.14A 1fm6D-5bz3A:
undetectable		 1fm6D-5bz3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A 162
CYH A 163
LEU A  51
LEU A 335
TYR A 259
 None
 1.19A 1fm6D-5cdeA:
undetectable		 1fm6D-5cdeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 GLY A 348
LEU A 248
MET A 247
LEU A 379
LEU A 206
 None
 1.46A 1fm6D-5e4rA:
undetectable		 1fm6D-5e4rA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 135
SER A  78
HIS A 354
LEU A 138
LEU A 192
 None
 1.08A 1fm6D-5ei0A:
undetectable		 1fm6D-5ei0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE

(Chitinophaga
pinensis) 		PF10091
(Glycoamylase) 		5 GLY A 429
SER A 222
MET A 421
LEU A 277
LEU A 190
 None
 1.37A 1fm6D-5gzhA:
undetectable		 1fm6D-5gzhA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		6 HIS A 267
TYR A 265
LEU A 312
LEU A 215
LEU A 180
TYR A 217
 None
 1.42A 1fm6D-5hy7A:
undetectable		 1fm6D-5hy7A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 156
CYH A 157
SER A 163
LEU A 241
TYR A 205
 TPP  A 701 (-3.5A)
None
None
None
None
 1.29A 1fm6D-5i51A:
undetectable		 1fm6D-5i51A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 SER A  61
HIS A 862
LEU A 608
MET A 528
LEU A  66
 None
 1.47A 1fm6D-5nd1A:
undetectable		 1fm6D-5nd1A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 209
CYH A 210
SER A 216
LEU A 294
TYR A 258
 TPP  A 801 (-3.5A)
None
None
None
None
 1.28A 1fm6D-5nd5A:
undetectable		 1fm6D-5nd5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		5 GLY A 313
LEU A 338
HIS A 450
LEU A 486
TYR A 482
 None
 1.46A 1fm6D-5t81A:
undetectable		 1fm6D-5t81A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  48
CYH A  47
HIS A 130
LEU A 241
LEU A 172
 EDO  A 403 ( 4.5A)
None
None
None
None
 1.42A 1fm6D-5u24A:
undetectable		 1fm6D-5u24A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhy ZV67 FAB CHAIN 2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  65
SER H 112
TYR H  90
LEU H  69
MET H  80
 None
 1.43A 1fm6D-5uhyH:
undetectable		 1fm6D-5uhyH:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 5 GLY A 120
LEU A 112
LEU A 208
LEU A  22
TYR A 414
 None
 1.39A 1fm6D-5wm4A:
undetectable		 1fm6D-5wm4A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 GLY A  60
HIS A 299
TYR A 237
LEU A  65
TYR A 219
 None
 1.49A 1fm6D-5yo8A:
undetectable		 1fm6D-5yo8A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 GLY A 187
LEU A 183
LEU A 231
LEU A 216
TYR A 227
 None
 1.28A 1fm6D-6bz0A:
undetectable		 1fm6D-6bz0A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv6 3-DEHYDROQUINATE
DEHYDRATASE

(Paraburkholderia
phymatum) 		no annotation 5 HIS A   8
LEU A  93
LEU A 100
LEU A  35
TYR A 133
 None
 1.30A 1fm6D-6cv6A:
undetectable		 1fm6D-6cv6A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv6 3-DEHYDROQUINATE
DEHYDRATASE

(Paraburkholderia
phymatum) 		no annotation 5 SER A  48
HIS A   8
LEU A  93
LEU A 100
LEU A  35
 None
 1.17A 1fm6D-6cv6A:
undetectable		 1fm6D-6cv6A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 5 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.38A 1fm6D-6d0sA:
undetectable		 1fm6D-6d0sA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 5 GLY B 421
SER B 269
MET B 321
LEU B  92
MET B  95
 None
 1.50A 1fm6D-6f5oB:
undetectable		 1fm6D-6f5oB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN
WISKOTT-ALDRICH
SYNDROME PROTEIN
WASP

(Homo sapiens) 		PF00071
(Ras)
PF00786
(PBD) 		4 ILE B   9
LEU A  79
VAL A  77
ILE A   4
 None
 0.90A 1fm6D-1ceeB:
undetectable		 1fm6D-1ceeB:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 ILE A1149
LEU A1182
VAL A1160
ILE A1158
 None
 0.89A 1fm6D-1ihmA:
undetectable		 1fm6D-1ihmA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 ILE A 159
LEU A 134
VAL A 203
ILE A 212
 None
 0.86A 1fm6D-1kgsA:
0.0		 1fm6D-1kgsA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9k NUCLEAR FACTOR OF
ACTIVATED T-CELLS,
CYTOPLASMIC 2

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 ILE C 567
LEU C 468
VAL C 545
ILE C 460
 None
 0.91A 1fm6D-1s9kC:
undetectable		 1fm6D-1s9kC:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shw EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF01404
(Ephrin_lbd) 		4 ILE B 286
LEU B 321
VAL B 296
ILE B 294
 None
 0.93A 1fm6D-1shwB:
undetectable		 1fm6D-1shwB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj5 CONSERVED
HYPOTHETICAL PROTEIN
TM0160

(Thermotoga
maritima) 		PF02577
(DNase-RNase) 		4 ILE A 118
LEU A  22
VAL A  20
ILE A  35
 None
 0.88A 1fm6D-1sj5A:
undetectable		 1fm6D-1sj5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ILE A 176
LEU A 237
VAL A 223
ILE A 221
 None
 0.74A 1fm6D-1tmoA:
0.0		 1fm6D-1tmoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujd KIAA0559 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  18
LEU A  82
VAL A  74
ILE A  53
 None
 0.90A 1fm6D-1ujdA:
undetectable		 1fm6D-1ujdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 ILE A 985
LEU A 981
VAL A 535
ILE A 533
 None
 0.94A 1fm6D-1urjA:
0.0		 1fm6D-1urjA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		4 ILE A 119
LEU A 158
VAL A 144
ILE A 192
 None
 0.75A 1fm6D-1vfwA:
0.0		 1fm6D-1vfwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhc PUTATIVE KHG/KDPG
ALDOLASE

(Haemophilus
influenzae) 		PF01081
(Aldolase) 		4 ILE A 123
LEU A 156
VAL A 132
ILE A 129
 None
 0.73A 1fm6D-1vhcA:
0.0		 1fm6D-1vhcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 ILE B  16
LEU A 145
VAL A 126
ILE A 130
 FON  A 451 (-4.1A)
None
None
None
 0.92A 1fm6D-1xzqB:
undetectable		 1fm6D-1xzqB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		4 ILE A   4
LEU A 113
VAL A 122
ILE A 105
 None
 0.88A 1fm6D-1ye8A:
undetectable		 1fm6D-1ye8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 ILE B 160
LEU B  25
VAL B 233
ILE B 229
 None
 0.85A 1fm6D-1zunB:
undetectable		 1fm6D-1zunB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ILE A  84
LEU A  54
VAL A  58
ILE A   3
 None
 0.93A 1fm6D-2ahrA:
undetectable		 1fm6D-2ahrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		4 ILE A 336
LEU A 351
VAL A 359
ILE A 333
 None
 0.83A 1fm6D-2e7jA:
undetectable		 1fm6D-2e7jA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ILE A 152
LEU A 159
VAL A 138
ILE A 117
 None
 0.89A 1fm6D-2ft3A:
undetectable		 1fm6D-2ft3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jd4 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		4 ILE A2901
LEU A3041
VAL A3003
ILE A3001
 None
 0.88A 1fm6D-2jd4A:
undetectable		 1fm6D-2jd4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00069
(Pkinase)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 ILE B 289
LEU A  76
VAL A  44
ILE A  49
 None
 0.92A 1fm6D-2jgzB:
3.4		 1fm6D-2jgzB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		4 ILE A 164
LEU A 205
VAL A 191
ILE A 243
 None
 0.67A 1fm6D-2owmA:
undetectable		 1fm6D-2owmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phc UNCHARACTERIZED
PROTEIN PH0987

(Pyrococcus
horikoshii) 		PF02682
(CT_C_D) 		4 ILE B 185
LEU B 128
VAL B 200
ILE B 199
 None
 0.91A 1fm6D-2phcB:
undetectable		 1fm6D-2phcB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbx EPHRIN TYPE-B
RECEPTOR 2

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		4 ILE A  86
LEU A 121
VAL A  96
ILE A  94
 None
 0.85A 1fm6D-2qbxA:
undetectable		 1fm6D-2qbxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 ILE A 107
LEU A 187
VAL A 175
ILE A 172
 None
 0.73A 1fm6D-2vhlA:
undetectable		 1fm6D-2vhlA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 201
LEU A 281
VAL A 307
ILE A 316
 None
 0.90A 1fm6D-2vk4A:
undetectable		 1fm6D-2vk4A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w50 ARMET-LIKE PROTEIN 1

(Homo sapiens) 		PF10208
(Armet) 		4 ILE A  97
LEU A  41
VAL A  73
ILE A  69
 None
 0.75A 1fm6D-2w50A:
undetectable		 1fm6D-2w50A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 ILE A 658
LEU A 635
VAL A 591
ILE A 685
 None
 0.81A 1fm6D-2x49A:
undetectable		 1fm6D-2x49A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr4 LECTIN

(Burkholderia
cenocepacia) 		PF07472
(PA-IIL) 		4 ILE A  93
LEU A   8
VAL A  64
ILE A  30
 None
 0.93A 1fm6D-2xr4A:
undetectable		 1fm6D-2xr4A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5b UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		4 ILE B 143
LEU B  27
VAL B 169
ILE B 173
 None
 0.71A 1fm6D-2z5bB:
undetectable		 1fm6D-2z5bB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		4 ILE B 143
LEU B  27
VAL B 169
ILE B 173
 None
 0.85A 1fm6D-2z5cB:
undetectable		 1fm6D-2z5cB:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 281
LEU A 330
VAL A 339
ILE A 341
 MC5  A   1 ( 4.8A)
MC5  A   1 (-4.4A)
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
 0.21A 1fm6D-3b0qA:
39.8		 1fm6D-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddy LUMAZINE PROTEIN

(Photobacterium
leiognathi) 		PF00677
(Lum_binding) 		4 ILE A  63
LEU A  83
VAL A  81
ILE A  12
 RBF  A 187 ( 4.6A)
None
None
None
 0.89A 1fm6D-3ddyA:
undetectable		 1fm6D-3ddyA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 ILE D 281
LEU D 330
VAL D 339
ILE D 341
 PLB  D 701 (-4.6A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
 0.20A 1fm6D-3dzuD:
37.0		 1fm6D-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e18 OXIDOREDUCTASE

(Listeria
innocua) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 106
LEU A  59
VAL A  67
ILE A  69
 None
 0.94A 1fm6D-3e18A:
undetectable		 1fm6D-3e18A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flt SAP-LIKE PENTRAXIN

(Limulus
polyphemus) 		PF00354
(Pentaxin) 		4 ILE A 142
LEU A  34
VAL A 168
ILE A 194
 None
 0.91A 1fm6D-3fltA:
undetectable		 1fm6D-3fltA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo8 TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF17481
(Phage_sheath_1N) 		4 ILE D 311
LEU D 195
VAL D 223
ILE D 323
 None
 0.87A 1fm6D-3fo8D:
undetectable		 1fm6D-3fo8D:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbj KIF13B PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		4 ILE A 123
LEU A 162
VAL A 148
ILE A 197
 None
 0.72A 1fm6D-3gbjA:
undetectable		 1fm6D-3gbjA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghf SEPTUM
SITE-DETERMINING
PROTEIN MINC

(Salmonella
enterica) 		PF05209
(MinC_N) 		4 ILE A  28
LEU A  86
VAL A  52
ILE A  50
 None
 0.87A 1fm6D-3ghfA:
undetectable		 1fm6D-3ghfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7r ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		4 ILE A  54
LEU A  92
VAL A 104
ILE A 101
 None
 0.93A 1fm6D-3h7rA:
undetectable		 1fm6D-3h7rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ILE B 145
LEU B 180
VAL B 159
ILE B 157
 None
 0.87A 1fm6D-3igzB:
undetectable		 1fm6D-3igzB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 4 ILE A 355
LEU A 189
VAL A 314
ILE A 113
 None
 0.87A 1fm6D-3j0hA:
undetectable		 1fm6D-3j0hA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgx D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Streptococcus
pyogenes) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A  37
LEU A  46
VAL A  52
ILE A 101
 None
 0.93A 1fm6D-3lgxA:
undetectable		 1fm6D-3lgxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		4 ILE A   6
LEU A  52
VAL A  87
ILE A  40
 None
 0.86A 1fm6D-3na6A:
undetectable		 1fm6D-3na6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ILE A 144
LEU A 179
VAL A 158
ILE A 156
 None
 0.89A 1fm6D-3nvlA:
undetectable		 1fm6D-3nvlA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		4 ILE A 246
LEU A 111
VAL A  73
ILE A  71
 None
 0.91A 1fm6D-3nwyA:
undetectable		 1fm6D-3nwyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyb POLY(A) RNA
POLYMERASE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 ILE A 204
LEU A 257
VAL A 294
ILE A 292
 None
 0.87A 1fm6D-3nybA:
undetectable		 1fm6D-3nybA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		4 ILE B 187
LEU B 168
VAL B 224
ILE B 164
 None
 0.94A 1fm6D-3o1hB:
undetectable		 1fm6D-3o1hB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 ILE A 362
LEU A 391
VAL A 329
ILE A 327
 None
 0.74A 1fm6D-3or2A:
undetectable		 1fm6D-3or2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 4 ILE A  69
LEU A  79
VAL A  82
ILE A 122
 None
 0.90A 1fm6D-3orjA:
undetectable		 1fm6D-3orjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ILE A 331
LEU A 254
VAL A 350
ILE A 348
 None
 0.77A 1fm6D-3p4sA:
undetectable		 1fm6D-3p4sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw3 OROTIDINE-5-PHOSPHAT
E
DECARBOXYLASE/OROTAT
E
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE
(OMPDCASE-OPRTASE,
PUTATIVE)

(Leishmania
infantum) 		PF00215
(OMPdecase) 		4 ILE A 248
LEU A 184
VAL A 198
ILE A 201
 None
 0.79A 1fm6D-3qw3A:
undetectable		 1fm6D-3qw3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qw4 UMP SYNTHASE

(Leishmania
donovani) 		PF00156
(Pribosyltran)
PF00215
(OMPdecase) 		4 ILE B 248
LEU B 184
VAL B 198
ILE B 201
 None
 0.89A 1fm6D-3qw4B:
undetectable		 1fm6D-3qw4B:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		4 ILE A   5
LEU A 165
VAL A 189
ILE A 192
 None
 0.93A 1fm6D-3rrlA:
undetectable		 1fm6D-3rrlA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF13944
(Calycin_like) 		4 ILE A 121
LEU A 117
VAL A  74
ILE A  72
 MLY  A 126 ( 4.1A)
MLY  A 130 ( 4.3A)
None
None
 0.90A 1fm6D-3rwxA:
undetectable		 1fm6D-3rwxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ILE A 550
LEU A 567
VAL A 607
ILE A 645
 None
 0.93A 1fm6D-3s29A:
undetectable		 1fm6D-3s29A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 ILE A  20
LEU A  54
VAL A 281
ILE A  45
 None
 0.81A 1fm6D-3s6dA:
undetectable		 1fm6D-3s6dA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujq LEGUME LECTIN

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		4 ILE A 189
LEU A 219
VAL A 143
ILE A 164
 None
 0.88A 1fm6D-3ujqA:
undetectable		 1fm6D-3ujqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ILE A 343
LEU A 253
VAL A 287
ILE A 246
 None
 0.91A 1fm6D-3vlaA:
undetectable		 1fm6D-3vlaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 ILE A 285
LEU A 212
VAL A 235
ILE A 207
 None
 0.94A 1fm6D-3vohA:
undetectable		 1fm6D-3vohA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwy D-LACTATE
DEHYDROGENASE

(Fusobacterium
nucleatum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 218
LEU A 287
VAL A 258
ILE A 255
 None
 0.73A 1fm6D-3wwyA:
undetectable		 1fm6D-3wwyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 ILE A 341
LEU A 314
VAL A 300
ILE A 268
 None
 0.83A 1fm6D-4ckbA:
undetectable		 1fm6D-4ckbA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e72 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF11738
(DUF3298) 		4 ILE A  69
LEU A  31
VAL A 121
ILE A 123
 None
 0.90A 1fm6D-4e72A:
undetectable		 1fm6D-4e72A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ef1 PHEROMONE
COB1/LIPOPROTEIN,
YAEC FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		4 ILE A 107
LEU A  59
VAL A  48
ILE A  44
 None
 0.88A 1fm6D-4ef1A:
undetectable		 1fm6D-4ef1A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 202
LEU A 173
VAL A 182
ILE A 186
 None
 0.92A 1fm6D-4egeA:
undetectable		 1fm6D-4egeA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 ILE A 245
LEU A 271
VAL A 107
ILE A 237
 None
 0.91A 1fm6D-4eqmA:
undetectable		 1fm6D-4eqmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt8 SENSOR PROTEIN VRAS

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		4 ILE A 221
LEU A 265
VAL A 273
ILE A 288
 None
 0.83A 1fm6D-4gt8A:
undetectable		 1fm6D-4gt8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ILE A 192
LEU A 199
VAL A 177
ILE A 175
 None
 0.93A 1fm6D-4hwvA:
undetectable		 1fm6D-4hwvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8i HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16227
(DUF4886) 		4 ILE A  80
LEU A 154
VAL A 120
ILE A  37
 None
 0.87A 1fm6D-4i8iA:
undetectable		 1fm6D-4i8iA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		4 ILE A 135
LEU A   7
VAL A  49
ILE A 102
 None
 0.88A 1fm6D-4i99A:
undetectable		 1fm6D-4i99A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		4 ILE A 126
LEU A 115
VAL A 145
ILE A 168
 None
 0.85A 1fm6D-4k3fA:
undetectable		 1fm6D-4k3fA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 376
LEU A 504
VAL A 522
ILE A 524
 None
 0.85A 1fm6D-4k9qA:
undetectable		 1fm6D-4k9qA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE

(Campylobacter
jejuni) 		PF00551
(Formyl_trans_N) 		4 ILE A  20
LEU A  48
VAL A  32
ILE A  57
 None
 0.92A 1fm6D-4lxyA:
undetectable		 1fm6D-4lxyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR

(Parabacteroides
distasonis) 		PF04773
(FecR)
PF16344
(DUF4974) 		4 ILE A 287
LEU A 265
VAL A 311
ILE A 315
 None
 0.92A 1fm6D-4m0hA:
undetectable		 1fm6D-4m0hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 4 ILE B 225
LEU B  53
VAL B   5
ILE B  26
 None
 0.91A 1fm6D-4mkiB:
undetectable		 1fm6D-4mkiB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvt E3 SUMO-PROTEIN
LIGASE PIAS3

(Homo sapiens) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 ILE A 242
LEU A 147
VAL A 260
ILE A 258
 UNX  A 508 ( 4.6A)
None
None
None
 0.68A 1fm6D-4mvtA:
undetectable		 1fm6D-4mvtA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		4 ILE A 165
LEU A 178
VAL A 184
ILE A 191
 None
 0.94A 1fm6D-4o8uA:
undetectable		 1fm6D-4o8uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		4 ILE A  51
LEU A  78
VAL A  92
ILE A  89
 None
 0.86A 1fm6D-4q6kA:
undetectable		 1fm6D-4q6kA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 ILE A  30
LEU A 238
VAL A  16
ILE A  43
 None
 0.88A 1fm6D-4rtbA:
undetectable		 1fm6D-4rtbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 ILE A 148
LEU A 176
VAL A 163
ILE A 161
 None
 0.85A 1fm6D-4rtbA:
undetectable		 1fm6D-4rtbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		4 ILE A 317
LEU A 309
VAL A 348
ILE A 350
 None
 0.78A 1fm6D-4ru4A:
undetectable		 1fm6D-4ru4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr1 GLUTAREDOXIN 3

(Alkaliphilus
oremlandii) 		PF00462
(Glutaredoxin) 		4 ILE A  69
LEU A  84
VAL A  27
ILE A   4
 CSO  A  66 ( 4.4A)
None
None
None
 0.94A 1fm6D-4tr1A:
undetectable		 1fm6D-4tr1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 ILE A 236
LEU A 331
VAL A 273
ILE A 313
 None
 0.87A 1fm6D-4uw2A:
undetectable		 1fm6D-4uw2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		4 ILE A 234
LEU A 347
VAL A 291
ILE A 380
 None
 0.90A 1fm6D-4wm0A:
undetectable		 1fm6D-4wm0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp3 MA1120

(Mycobacterium
avium) 		PF00211
(Guanylate_cyc) 		4 ILE A  81
LEU A 124
VAL A 142
ILE A 140
 None
 0.57A 1fm6D-4wp3A:
undetectable		 1fm6D-4wp3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yio SUPEROXIDE DISMUTASE

(Streptococcus
thermophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A 102
LEU A 200
VAL A 133
ILE A 158
 None
 0.94A 1fm6D-4yioA:
undetectable		 1fm6D-4yioA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9g MANGANESE SUPEROXIDE
DISMUTASE

(Sphingobacterium
spiritivorum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A 113
LEU A  95
VAL A 193
ILE A 188
 None
 0.93A 1fm6D-5a9gA:
undetectable		 1fm6D-5a9gA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 4 ILE A 291
LEU A 118
VAL A 127
ILE A 314
 None
 0.92A 1fm6D-5b5xA:
undetectable		 1fm6D-5b5xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5che GLUTAMYL-TRNA
REDUCTASE-BINDING
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF10615
(DUF2470) 		4 ILE C 219
LEU C 229
VAL C 259
ILE C 261
 None
 0.93A 1fm6D-5cheC:
undetectable		 1fm6D-5cheC:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L21

(Deinococcus
radiodurans) 		PF00829
(Ribosomal_L21p) 		4 ILE O   5
LEU O  25
VAL O  22
ILE O  20
 None
 0.93A 1fm6D-5dm6O:
undetectable		 1fm6D-5dm6O:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eip YTH
DOMAIN-CONTAINING
PROTEIN MMI1

(Schizosaccharomyces
pombe) 		PF04146
(YTH) 		4 ILE A 448
LEU A 356
VAL A 396
ILE A 394
 None
 0.87A 1fm6D-5eipA:
undetectable		 1fm6D-5eipA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 ILE A 315
LEU A 357
VAL A 360
ILE A 321
 None
 0.87A 1fm6D-5hucA:
undetectable		 1fm6D-5hucA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 4 ILE F 740
LEU F 834
VAL F 637
ILE F 770
 None
 0.86A 1fm6D-5it5F:
undetectable		 1fm6D-5it5F:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		4 ILE A  86
LEU A 229
VAL A 238
ILE A 189
 None
 0.75A 1fm6D-5iw7A:
undetectable		 1fm6D-5iw7A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 ILE A 121
LEU A 112
VAL A  91
ILE A  94
 None
 0.82A 1fm6D-5jrlA:
undetectable		 1fm6D-5jrlA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 ILE A 698
LEU A 662
VAL A 669
ILE A 667
 None
 0.89A 1fm6D-5l46A:
undetectable		 1fm6D-5l46A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3)
PF06444
(NADH_dehy_S2_C) 		4 ILE N  13
LEU K  73
VAL J 167
ILE J 163
 None
 0.85A 1fm6D-5lc5N:
undetectable		 1fm6D-5lc5N:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		4 ILE A2337
LEU A2478
VAL A2444
ILE A2442
 None
 0.86A 1fm6D-5mc9A:
undetectable		 1fm6D-5mc9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 ILE A 416
LEU A 518
VAL A 522
ILE A 493
 None
 0.82A 1fm6D-5ot1A:
undetectable		 1fm6D-5ot1A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t09 TYPE III SECRETION
SYSTEM EFFECTOR
HOPBA1

(Pseudomonas
syringae) 		no annotation 4 ILE A  65
LEU A  97
VAL A 137
ILE A 135
 None
 0.68A 1fm6D-5t09A:
undetectable		 1fm6D-5t09A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		4 ILE B 297
LEU B  82
VAL B  38
ILE B  34
 None
 0.93A 1fm6D-5vblB:
undetectable		 1fm6D-5vblB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 4 ILE A 475
LEU A 444
VAL A 427
ILE A 437
 None
 0.94A 1fm6D-5wzkA:
undetectable		 1fm6D-5wzkA:
19.72