SIMILAR PATTERNS OF AMINO ACIDS FOR 1FM4_A_DXCA1002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		6 VAL A 239
ILE A   9
ILE A  51
ASN A  12
TYR A  28
LEU A 232
 None
 1.28A 1fm4A-1dq3A:
undetectable		 1fm4A-1dq3A:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		6 ILE A  56
TYR A  81
TYR A  83
ILE A  98
TYR A 120
LEU A 143
 None
 0.80A 1fm4A-1e09A:
21.3		 1fm4A-1e09A:
57.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		5 PHE A  22
VAL A  30
ILE A  98
TYR A 120
LEU A 143
 None
 1.06A 1fm4A-1e09A:
21.3		 1fm4A-1e09A:
57.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		6 VAL A  30
TYR A  81
TYR A  83
ILE A  98
TYR A 120
LEU A 143
 None
 1.14A 1fm4A-1e09A:
21.3		 1fm4A-1e09A:
57.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma) 		PF01593
(Amino_oxidase) 		5 ILE A 408
TYR A 357
VAL A 393
ILE A 327
SER A 415
 None
 1.18A 1fm4A-1f8rA:
undetectable		 1fm4A-1f8rA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 VAL A  50
ILE A  68
TYR A 124
ASN A  78
ASN A 311
 None
 1.26A 1fm4A-1h79A:
undetectable		 1fm4A-1h79A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Staphylococcus
aureus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 VAL A  95
ILE A 312
TYR A 149
VAL A 309
ASN A  83
 None
None
FAD  A 401 (-3.4A)
None
FAD  A 401 (-3.6A)
 1.25A 1fm4A-1hskA:
undetectable		 1fm4A-1hskA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 PHE A 344
VAL A 337
ILE A 260
TYR A  75
LEU A  37
 None
 1.17A 1fm4A-1jkmA:
undetectable		 1fm4A-1jkmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE B 203
VAL B 600
ILE B 163
ASN B 176
LEU B 566
 None
 1.19A 1fm4A-1m2vB:
undetectable		 1fm4A-1m2vB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		5 ILE A 408
TYR A 357
VAL A 393
ILE A 327
SER A 415
 None
 1.20A 1fm4A-1tdkA:
undetectable		 1fm4A-1tdkA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 VAL A  41
TYR A 188
VAL A 184
SER A 176
LEU A  13
 None
 1.28A 1fm4A-1wd5A:
undetectable		 1fm4A-1wd5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yn5 EAPH2

(Staphylococcus
aureus) 		PF03642
(MAP) 		5 VAL A  48
ILE A 107
VAL A 117
SER A  74
LEU A  67
 None
 1.21A 1fm4A-1yn5A:
undetectable		 1fm4A-1yn5A:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bk0 MAJOR ALLERGEN API G
1

(Apium
graveolens) 		PF00407
(Bet_v_1) 		6 ILE A  56
TYR A  83
VAL A  85
ILE A  98
ASN A 100
LEU A 143
 None
 0.81A 1fm4A-2bk0A:
23.2		 1fm4A-2bk0A:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bk0 MAJOR ALLERGEN API G
1

(Apium
graveolens) 		PF00407
(Bet_v_1) 		6 PHE A  23
TYR A  83
VAL A  85
ILE A  98
ASN A 100
LEU A 143
 None
 0.69A 1fm4A-2bk0A:
23.2		 1fm4A-2bk0A:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bk0 MAJOR ALLERGEN API G
1

(Apium
graveolens) 		PF00407
(Bet_v_1) 		5 PHE A  23
VAL A  27
VAL A  85
ILE A  98
ASN A 100
 None
 1.26A 1fm4A-2bk0A:
23.2		 1fm4A-2bk0A:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 PHE A 144
VAL A  76
TYR A 212
ILE A 228
LEU A  90
 None
 1.22A 1fm4A-2cmhA:
undetectable		 1fm4A-2cmhA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 VAL A 503
ILE A  90
TYR A  75
SER A  94
LEU A 114
 None
None
SO4  A1001 (-4.6A)
SO4  A1001 (-3.1A)
None
 1.15A 1fm4A-2cw7A:
undetectable		 1fm4A-2cw7A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0z VIRUS-LIKE PARTICLE

(Pyrococcus
furiosus) 		PF04454
(Linocin_M18) 		5 VAL A 311
ILE A 331
ILE A 205
ASN A 287
SER A 129
 None
 1.11A 1fm4A-2e0zA:
undetectable		 1fm4A-2e0zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 PHE A  53
VAL A  71
ILE A 245
VAL A 307
ASN A 188
 None
 1.24A 1fm4A-2eaeA:
undetectable		 1fm4A-2eaeA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PHE A 211
TYR A 307
ILE A 312
TYR A 324
LEU A 215
 None
 1.27A 1fm4A-2fuvA:
3.3		 1fm4A-2fuvA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		5 TYR A   6
VAL A   4
ILE A  27
ASN A  29
LEU A 165
 None
 1.18A 1fm4A-2gsjA:
undetectable		 1fm4A-2gsjA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		5 VAL A 316
ILE A 171
VAL A 138
SER A 298
LEU A 309
 None
None
FAD  A 500 (-4.0A)
None
None
 1.18A 1fm4A-2gv8A:
undetectable		 1fm4A-2gv8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Saccharomyces
cerevisiae) 		PF03770
(IPK) 		5 PHE A 352
ILE A 167
TYR A 218
ILE A 129
LEU A 348
 None
 1.23A 1fm4A-2iewA:
undetectable		 1fm4A-2iewA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A 406
VAL A  38
TYR A 142
SER A 132
LEU A 127
 None
 1.20A 1fm4A-2iikA:
undetectable		 1fm4A-2iikA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 PHE A 704
VAL A 728
VAL A 767
SER A 778
LEU A 702
 None
 1.19A 1fm4A-2rdyA:
undetectable		 1fm4A-2rdyA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		5 PHE A2421
VAL A2360
VAL A2483
SER A2406
LEU A2423
 None
 1.00A 1fm4A-2wjsA:
undetectable		 1fm4A-2wjsA:
15.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wql MAJOR ALLERGEN DAU C
1

(Daucus carota) 		PF00407
(Bet_v_1) 		5 ILE A  56
TYR A  81
VAL A  85
ILE A  98
LEU A 143
 None
P4C  A 200 ( 4.5A)
None
PEG  A 201 ( 4.7A)
P4C  A 200 (-4.4A)
 0.67A 1fm4A-2wqlA:
23.0		 1fm4A-2wqlA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE

(Helianthus
annuus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A 420
VAL A  50
ILE A 150
TYR A 155
LEU A 140
 None
 1.03A 1fm4A-2wuaA:
undetectable		 1fm4A-2wuaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A  91
ILE A  25
TYR A 130
ASN A 319
LEU A  93
 None
 1.20A 1fm4A-2xf8A:
undetectable		 1fm4A-2xf8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 PHE A 303
VAL A 305
ILE A 147
ILE A 172
LEU A 124
 None
 1.19A 1fm4A-2yheA:
undetectable		 1fm4A-2yheA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 PHE A 212
VAL A 309
VAL A 372
ILE A 358
TYR A 338
 None
None
AMP  A1001 (-4.8A)
None
None
 1.26A 1fm4A-2zr2A:
undetectable		 1fm4A-2zr2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN

(Bombyx mori) 		PF06585
(JHBP) 		5 VAL A  45
ILE A  97
TYR A 201
ILE A 154
LEU A  48
 None
 1.23A 1fm4A-3a1zA:
undetectable		 1fm4A-3a1zA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		5 VAL A 125
ILE A 294
ILE A  95
ASN A 115
LEU A 326
 None
 1.19A 1fm4A-3bc8A:
undetectable		 1fm4A-3bc8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f43 PUTATIVE ANTI-SIGMA
FACTOR ANTAGONIST
TM1081

(Thermotoga
maritima) 		PF01740
(STAS) 		5 PHE A  27
VAL A  31
VAL A  97
ILE A  99
LEU A  13
 None
 1.26A 1fm4A-3f43A:
undetectable		 1fm4A-3f43A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 ILE A 261
TYR A 192
VAL A 204
ILE A 233
TYR A 228
 None
 1.27A 1fm4A-3h8lA:
undetectable		 1fm4A-3h8lA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		5 ILE A 263
TYR A 192
VAL A 204
ILE A 233
LEU A  45
 None
 1.12A 1fm4A-3h8lA:
undetectable		 1fm4A-3h8lA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 PHE A1024
VAL A1021
VAL A1538
ILE A1605
SER A1602
 None
 1.17A 1fm4A-3hmjA:
undetectable		 1fm4A-3hmjA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 PHE A 253
ILE A 514
VAL A 461
ILE A 433
LEU A 254
 None
 1.19A 1fm4A-3i7fA:
undetectable		 1fm4A-3i7fA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itq PROLYL
4-HYDROXYLASE, ALPHA
SUBUNIT DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13640
(2OG-FeII_Oxy_3) 		5 VAL A  47
ILE A  99
VAL A 210
ILE A 143
LEU A  44
 None
 1.22A 1fm4A-3itqA:
undetectable		 1fm4A-3itqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		5 VAL A 350
ILE A 300
ILE A 271
ASN A 272
TYR A  41
 None
None
FAD  A 401 (-4.3A)
None
None
 1.28A 1fm4A-3kljA:
undetectable		 1fm4A-3kljA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		5 ILE A 408
TYR A 357
VAL A 393
ILE A 327
SER A 415
 None
 1.25A 1fm4A-3kveA:
undetectable		 1fm4A-3kveA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 PHE A 304
VAL A  61
ILE A 103
TYR A 128
LEU A 211
 None
 1.13A 1fm4A-3l0oA:
undetectable		 1fm4A-3l0oA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 VAL A 392
ILE A 380
ILE A 346
ASN A 350
LEU A 365
 None
 1.28A 1fm4A-3p11A:
undetectable		 1fm4A-3p11A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6v BETA-LACTAMASE

(Serratia
fonticola) 		PF00753
(Lactamase_B) 		5 VAL A 103
ILE A  80
VAL A 112
SER A  71
LEU A  44
 None
 1.26A 1fm4A-3q6vA:
undetectable		 1fm4A-3q6vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		5 VAL A   7
VAL A 324
ILE A 307
SER A 336
LEU A 342
 None
 1.18A 1fm4A-3rjuA:
undetectable		 1fm4A-3rjuA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sft CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE

(Thermotoga
maritima) 		PF01339
(CheB_methylest) 		5 VAL A 214
ILE A 188
VAL A 281
SER A 172
LEU A 206
 None
 1.21A 1fm4A-3sftA:
undetectable		 1fm4A-3sftA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trj PHOSPHOHEPTOSE
ISOMERASE

(Francisella
tularensis) 		PF13580
(SIS_2) 		5 ILE A 180
VAL A 165
ILE A 173
SER A  54
LEU A 116
 None
 1.24A 1fm4A-3trjA:
undetectable		 1fm4A-3trjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 VAL A 247
ILE A  32
ILE A 338
SER A 312
LEU A 269
 None
 1.15A 1fm4A-3vm7A:
undetectable		 1fm4A-3vm7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 118
ILE A  74
ILE A  70
ASN A  92
SER A 130
 None
 1.09A 1fm4A-3wpeA:
undetectable		 1fm4A-3wpeA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 PHE A 157
VAL A 285
ILE A 200
VAL A 219
SER A 266
 None
None
None
GOL  A 410 ( 4.8A)
None
 1.22A 1fm4A-3wq1A:
undetectable		 1fm4A-3wq1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		5 PHE A 113
VAL A 115
ILE A 230
ILE A 149
LEU A  93
 None
 1.06A 1fm4A-4b43A:
undetectable		 1fm4A-4b43A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c82 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Plasmodium
falciparum) 		PF02542
(YgbB) 		5 VAL A 112
ILE A 120
ILE A 197
ASN A 196
LEU A 100
 None
 1.18A 1fm4A-4c82A:
undetectable		 1fm4A-4c82A:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c94 FRA A 3 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		6 ILE A  57
TYR A  82
TYR A  84
ILE A  99
TYR A 120
LEU A 143
 KXN  A 160 ( 4.7A)
None
None
None
None
None
 0.98A 1fm4A-4c94A:
24.2		 1fm4A-4c94A:
55.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9c MAJOR STRAWBERRY
ALLERGEN FRA A 1-E

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		5 PHE A  23
ILE A  57
TYR A  82
TYR A  84
ILE A  99
 None
 1.00A 1fm4A-4c9cA:
23.8		 1fm4A-4c9cA:
50.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9c MAJOR STRAWBERRY
ALLERGEN FRA A 1-E

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		5 PHE A  23
TYR A  82
TYR A  84
ILE A  99
TYR A 121
 None
 0.69A 1fm4A-4c9cA:
23.8		 1fm4A-4c9cA:
50.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		5 ILE A 219
TYR A 284
VAL A 227
ILE A 286
TYR A 288
 None
 1.24A 1fm4A-4ckbA:
undetectable		 1fm4A-4ckbA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		5 PHE A 192
VAL A 308
ILE A 245
TYR A 341
LEU A 311
 None
 1.24A 1fm4A-4eysA:
undetectable		 1fm4A-4eysA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6z GLUTAMATE-TRNA
LIGASE

(Burkholderia
thailandensis) 		PF00749
(tRNA-synt_1c) 		5 TYR A 304
VAL A 253
ILE A  17
ASN A  21
SER A  24
 None
 1.28A 1fm4A-4g6zA:
undetectable		 1fm4A-4g6zA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		5 PHE A 124
ILE A 386
VAL A 119
ASN A  82
LEU A 102
 None
 1.27A 1fm4A-4gb7A:
undetectable		 1fm4A-4gb7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Gallus gallus;
Rattus
norvegicus;
Discosoma sp.) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 ILE A 262
TYR A  88
VAL A  92
ILE A  76
LEU A 218
 None
None
None
NRQ  A 224 ( 4.7A)
None
 1.21A 1fm4A-4i2yA:
undetectable		 1fm4A-4i2yA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jhi MTN13 PROTEIN

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 VAL A 148
TYR A  80
TYR A  82
ILE A  98
TYR A 120
 None
None
EMU  A 202 (-4.9A)
EMU  A 202 ( 4.9A)
None
 1.12A 1fm4A-4jhiA:
19.8		 1fm4A-4jhiA:
41.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjz TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		5 PHE A 113
VAL A 115
ILE A 230
ILE A 149
LEU A  93
 None
 1.14A 1fm4A-4kjzA:
undetectable		 1fm4A-4kjzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 ILE A 586
TYR A 611
VAL A 591
ILE A 544
ASN A 610
 None
 1.23A 1fm4A-4ktpA:
undetectable		 1fm4A-4ktpA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		5 PHE A  80
VAL A  88
TYR A 112
SER A  66
LEU A  50
 None
 1.10A 1fm4A-4lk4A:
undetectable		 1fm4A-4lk4A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7

(Drosophila
melanogaster) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 ILE A 186
ILE A 231
ASN A 152
ASN A 154
LEU A 101
 None
 1.11A 1fm4A-4lw6A:
undetectable		 1fm4A-4lw6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		PF01239
(PPTA)
PF00432
(Prenyltrans) 		5 VAL B 243
ILE A  78
ILE A  66
ASN A  70
TYR A  39
 None
 1.20A 1fm4A-4mbgB:
undetectable		 1fm4A-4mbgB:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8u UNCHARACTERIZED
PROTEIN PF2046

(Pyrococcus
furiosus) 		PF13680
(DUF4152) 		5 VAL A  80
ILE A 137
VAL A 140
ILE A 142
LEU A  37
 None
 1.16A 1fm4A-4o8uA:
undetectable		 1fm4A-4o8uA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 136
ILE A 104
ASN A 122
SER A 148
LEU A 131
 None
 1.05A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 160
ILE A 128
ASN A 146
SER A 172
LEU A 155
 None
 1.04A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 184
ILE A 152
ASN A 170
SER A 196
LEU A 179
 None
 1.05A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 208
ILE A 176
ASN A 194
SER A 220
LEU A 203
 None
 1.08A 1fm4A-4psjA:
undetectable		 1fm4A-4psjA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdh VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 9
CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 PHE A 121
VAL A  92
ILE A  88
SER A 133
LEU A 115
 None
 1.10A 1fm4A-4qdhA:
undetectable		 1fm4A-4qdhA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 VAL B 250
ILE B 343
ASN B 207
SER B 143
LEU B 118
 None
 1.24A 1fm4A-4um8B:
undetectable		 1fm4A-4um8B:
10.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		10 PHE A  22
ILE A  56
TYR A  81
TYR A  83
VAL A  85
ILE A  98
ASN A 100
ASN A 118
TYR A 120
SER A 136
 None
 0.67A 1fm4A-4z3lA:
27.6		 1fm4A-4z3lA:
91.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		10 PHE A  22
ILE A  56
TYR A  83
VAL A  85
ILE A  98
ASN A 100
ASN A 118
TYR A 120
SER A 136
LEU A 143
 None
 0.56A 1fm4A-4z3lA:
27.6		 1fm4A-4z3lA:
91.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A

(Betula pendula) 		PF00407
(Bet_v_1) 		9 PHE A  30
TYR A  83
VAL A  85
ILE A  98
ASN A 100
ASN A 118
TYR A 120
SER A 136
LEU A 143
 None
 1.44A 1fm4A-4z3lA:
27.6		 1fm4A-4z3lA:
91.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amw FRA A 2 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		6 PHE A  23
ILE A  57
TYR A  82
TYR A  84
ILE A  99
LEU A 144
 None
 0.81A 1fm4A-5amwA:
24.5		 1fm4A-5amwA:
55.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amw FRA A 2 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		6 PHE A  23
TYR A  82
TYR A  84
ILE A  99
TYR A 121
LEU A 144
 None
 0.69A 1fm4A-5amwA:
24.5		 1fm4A-5amwA:
55.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c9y PROTEIN LLR18A

(Lupinus luteus) 		PF00407
(Bet_v_1) 		5 VAL A  30
ILE A  55
TYR A  80
TYR A  82
ILE A  97
 None
 1.09A 1fm4A-5c9yA:
19.1		 1fm4A-5c9yA:
45.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec5 LYSENIN

(Eisenia fetida) 		no annotation 5 VAL A 281
ILE A 170
ASN A 215
SER A 195
LEU A 192
 None
 1.22A 1fm4A-5ec5A:
undetectable		 1fm4A-5ec5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 5 PHE A 391
VAL A 283
ILE A 297
ASN A 529
LEU A 539
 None
 1.10A 1fm4A-5fodA:
undetectable		 1fm4A-5fodA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		5 VAL A 185
ILE A 193
VAL A 219
ILE A 171
LEU A 149
 None
 1.17A 1fm4A-5frsA:
undetectable		 1fm4A-5frsA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fui ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF03422
(CBM_6) 		5 VAL A 360
ILE A 383
TYR A 315
ILE A 378
LEU A 330
 None
 1.24A 1fm4A-5fuiA:
undetectable		 1fm4A-5fuiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5t ARGONAUTE

(Methanocaldococcus
jannaschii) 		PF02171
(Piwi) 		5 ILE A 684
TYR A 522
VAL A 520
ILE A 531
LEU A 678
 None
 1.24A 1fm4A-5g5tA:
undetectable		 1fm4A-5g5tA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 PHE A 231
ILE A 273
ASN A 250
SER A 225
LEU A 238
 None
 1.22A 1fm4A-5gkqA:
undetectable		 1fm4A-5gkqA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 PHE A 145
ILE A 234
ASN A  14
ASN A  37
LEU A  69
 None
 0.97A 1fm4A-5iclA:
undetectable		 1fm4A-5iclA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ILE A 899
VAL A 849
ILE A 851
ASN A 912
ASN A 853
 None
 1.29A 1fm4A-5jm0A:
undetectable		 1fm4A-5jm0A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
PF01759
(NTR)
PF07677
(A2M_recep) 		5 TYR C1559
VAL B1306
ILE B1307
TYR B1267
LEU B1078
 None
 1.00A 1fm4A-5jpnC:
undetectable		 1fm4A-5jpnC:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		5 VAL A 123
TYR A 173
TYR A 165
SER A 140
LEU A 148
 None
 1.10A 1fm4A-5k9xA:
undetectable		 1fm4A-5k9xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA

(Staphylococcus
aureus) 		PF03255
(ACCA) 		5 VAL A 106
ILE A 189
ILE A 261
SER A 281
LEU A 101
 None
 1.26A 1fm4A-5kdrA:
undetectable		 1fm4A-5kdrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		5 PHE A2318
VAL A2444
ILE A2339
SER A2314
LEU A2478
 None
 1.26A 1fm4A-5mc9A:
undetectable		 1fm4A-5mc9A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 5 VAL A 725
ILE A 179
VAL A 159
ASN A  39
LEU A 119
 None
 1.26A 1fm4A-5mpmA:
undetectable		 1fm4A-5mpmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 PHE A 294
ILE A 289
VAL A 450
ILE A 477
SER A 433
 None
 1.21A 1fm4A-5mswA:
undetectable		 1fm4A-5mswA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nem INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 VAL B 247
ILE B 340
ASN B 204
SER B 140
LEU B 115
 None
 1.18A 1fm4A-5nemB:
undetectable		 1fm4A-5nemB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 PHE A1005
VAL A1003
ILE A 944
SER A 986
LEU A1031
 None
None
None
G  B  -2 ( 3.2A)
None
 1.27A 1fm4A-5ng6A:
undetectable		 1fm4A-5ng6A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		5 ILE A 408
TYR A 357
VAL A 393
ILE A 327
SER A 415
 None
 1.17A 1fm4A-5ts5A:
undetectable		 1fm4A-5ts5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE

(Streptococcus
pneumoniae) 		no annotation 5 VAL A  75
ILE A 354
VAL A 219
SER A 346
LEU A 342
 None
 1.23A 1fm4A-5wpkA:
3.9		 1fm4A-5wpkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxu 11S GLOBULIN

(Wrightia
tinctoria) 		no annotation 5 ILE A  80
ILE A 388
ASN A 349
TYR A 394
LEU A 331
 None
 1.23A 1fm4A-5wxuA:
undetectable		 1fm4A-5wxuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 PHE A 119
ILE A  75
ILE A  71
ASN A  93
SER A 131
 None
 1.13A 1fm4A-5zlnA:
undetectable		 1fm4A-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghc -

(-) 		no annotation 5 PHE A  86
VAL A  59
ILE A  47
SER A  92
LEU A  88
 None
 1.05A 1fm4A-6ghcA:
undetectable		 1fm4A-6ghcA:
undetectable