SIMILAR PATTERNS OF AMINO ACIDS FOR 1FM4_A_DXCA1001_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c30 | CARBAMOYL PHOSPHATESYNTHETASE: LARGESUBUNIT (Escherichiacoli) |
PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | PRO A 345PHE A 348PRO A 350THR A 315ILE A 230 | None | 1.39A | 1fm4A-1c30A:0.7 | 1fm4A-1c30A:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cov | COXSACKIEVIRUS COATPROTEIN (Enterovirus B) |
PF00073(Rhv) | 5 | PHE 3 85PRO 3 86PHE 3 189PRO 3 137ILE 3 171 | None | 1.47A | 1fm4A-1cov3:0.0 | 1fm4A-1cov3:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evs | ONCOSTATIN M (Homo sapiens) |
PF01291(LIF_OSM) | 5 | PRO A 57PHE A 176THR A 21ILE A 118ALA A 76 | None | 1.00A | 1fm4A-1evsA:undetectable | 1fm4A-1evsA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 5 | PHE A 508PRO A 509THR A 179ILE A 278SER A 575 | None | 1.29A | 1fm4A-1l5jA:0.0 | 1fm4A-1l5jA:11.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sky | F1-ATPASEF1-ATPASE (Bacillus sp.PS3;Bacillus sp.PS3) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N)PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 5 | PHE B 349THR B 207ILE E 358ALA E 327SER E 351 | None | 1.32A | 1fm4A-1skyB:0.0 | 1fm4A-1skyB:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEBETA CHAIN 1 (Pyrococcusfuriosus) |
PF00291(PALP) | 5 | PHE B 236PRO B 238PHE B 239PRO B 219GLN B 210 | None | 1.39A | 1fm4A-1wdwB:0.0 | 1fm4A-1wdwB:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xuv | HYPOTHETICAL PROTEINMM0500 (Methanosarcinamazei) |
PF08327(AHSA1) | 5 | PHE A 136PHE A 102ILE A 154TYR A 158SER A 132 | None | 1.29A | 1fm4A-1xuvA:13.8 | 1fm4A-1xuvA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7l | UBIQUITIN-ACTIVATINGENZYME E1 1 (Mus musculus) |
PF10585(UBA_e1_thiolCys) | 5 | PRO A 638ILE A 875GLN A 646ALA A 648SER A 866 | NoneNoneTBR A 999 (-3.1A)NoneNone | 1.36A | 1fm4A-1z7lA:0.0 | 1fm4A-1z7lA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bru | NAD(P)TRANSHYDROGENASESUBUNIT BETA (Escherichiacoli) |
PF02233(PNTB) | 5 | PHE C 163PHE C 164PRO C 161GLN C 123ALA C 121 | None | 1.23A | 1fm4A-2bruC:0.0 | 1fm4A-2bruC:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eja | UROPORPHYRINOGENDECARBOXYLASE (Aquifexaeolicus) |
PF01208(URO-D) | 5 | PHE A 237PHE A 199ILE A 264TYR A 308MET A 24 | None | 1.48A | 1fm4A-2ejaA:undetectable | 1fm4A-2ejaA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fn9 | RIBOSE ABCTRANSPORTER,PERIPLASMICRIBOSE-BINDINGPROTEIN (Thermotogamaritima) |
PF13407(Peripla_BP_4) | 5 | PHE A 86PHE A 63THR A 43ILE A 72ALA A 78 | None | 1.50A | 1fm4A-2fn9A:undetectable | 1fm4A-2fn9A:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi1 | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE 2 (Salmonellaenterica) |
PF04166(PdxA) | 5 | PRO A 123PRO A 18THR A 43ILE A 52ALA A 302 | None | 1.49A | 1fm4A-2hi1A:undetectable | 1fm4A-2hi1A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jcj | N-ACETYLLACTOSAMINIDEALPHA-1,3-GALACTOSYLTRANSFERASE (Bos taurus) |
PF03414(Glyco_transf_6) | 5 | PHE A 234PHE A 230GLN A 247ALA A 282MET A 224 | NoneNoneTRS A1369 (-4.0A) MN A1367 ( 4.9A)None | 1.38A | 1fm4A-2jcjA:undetectable | 1fm4A-2jcjA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8n | LACTOSE PERMEASE (Escherichiacoli) |
PF01306(LacY_symp) | 5 | PHE A 30PHE A 29PRO A 28PHE A 27ALA A 244 | None | 1.49A | 1fm4A-2v8nA:undetectable | 1fm4A-2v8nA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh0 | UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINEN-ACYLTRANSFERASE (Escherichiacoli) |
PF00132(Hexapep)PF04613(LpxD)PF14602(Hexapep_2) | 5 | PHE A 41THR A 92ALA A 34SER A 33MET A 31 | None | 1.24A | 1fm4A-3eh0A:undetectable | 1fm4A-3eh0A:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gd5 | ORNITHINECARBAMOYLTRANSFERASE (Gloeobacterviolaceus) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | PRO A 194THR A 188ILE A 184ALA A 200SER A 203 | None | 1.49A | 1fm4A-3gd5A:undetectable | 1fm4A-3gd5A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv9 | TRANSCRIPTIONALREGULATOR, LYSRFAMILY (Neisseriameningitidis) |
PF03466(LysR_substrate) | 5 | PRO A 268PHE A 165PRO A 246THR A 100ILE A 232 | None | 1.44A | 1fm4A-3jv9A:undetectable | 1fm4A-3jv9A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9h | PF-32 PROTEIN (Borreliellaburgdorferi) |
PF13614(AAA_31) | 5 | PHE A 168PHE A 169THR A 131ILE A 151SER A 162 | None | 1.47A | 1fm4A-3k9hA:undetectable | 1fm4A-3k9hA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kos | HTH-TYPETRANSCRIPTIONALACTIVATOR AMPR (Citrobacterfreundii) |
PF03466(LysR_substrate) | 5 | PHE A 242PRO A 254ILE A 183ALA A 228MET A 224 | None | 1.08A | 1fm4A-3kosA:undetectable | 1fm4A-3kosA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2k | EHPF (Pantoeaagglomerans) |
PF00501(AMP-binding) | 5 | PRO A 320PHE A 291PRO A 290ALA A 26MET A 28 | None | 1.40A | 1fm4A-3l2kA:undetectable | 1fm4A-3l2kA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2k | EHPF (Pantoeaagglomerans) |
PF00501(AMP-binding) | 5 | PRO A 320PHE A 291PRO A 290ILE A 59ALA A 26 | None | 1.41A | 1fm4A-3l2kA:undetectable | 1fm4A-3l2kA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsl | PUTATIVE EXPORTEDPROTEIN (Bordetellabronchiseptica) |
PF13379(NMT1_2) | 5 | PHE A 238PRO A 235GLN A 79ALA A 86SER A 85 | None | 1.42A | 1fm4A-3qslA:undetectable | 1fm4A-3qslA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qwb | PROBABLE QUINONEOXIDOREDUCTASE (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | PHE A 290ILE A 277GLN A 132ALA A 136SER A 138 | NoneNoneNDP A 335 (-3.6A)NoneNone | 1.35A | 1fm4A-3qwbA:undetectable | 1fm4A-3qwbA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zsc | PECTATETRISACCHARIDE-LYASE (Thermotogamaritima) |
PF00544(Pec_lyase_C) | 5 | PHE A 226PRO A 227PHE A 260PRO A 262MET A 253 | None | 1.30A | 1fm4A-3zscA:undetectable | 1fm4A-3zscA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | PRO A 585ILE A 354TYR A 348ALA A 501SER A 500 | None | 0.97A | 1fm4A-4c7vA:undetectable | 1fm4A-4c7vA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d47 | LEVANSUCRASE (Erwiniaamylovora) |
PF02435(Glyco_hydro_68) | 5 | PHE A 53PRO A 206PHE A 207TYR A 4ALA A 262 | None | 1.47A | 1fm4A-4d47A:undetectable | 1fm4A-4d47A:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dpk | MALONYL-COA/SUCCINYL-COA REDUCTASE (Sulfurisphaeratokodaii) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | PHE A 99PHE A 104PRO A 105THR A 150ALA A 10 | None | 1.11A | 1fm4A-4dpkA:undetectable | 1fm4A-4dpkA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e5t | MANDELATE RACEMASE /MUCONATE LACTONIZINGENZYME, C-TERMINALDOMAIN PROTEIN (Labrenziaalexandrii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | PRO A 247PRO A 241THR A 214GLN A 286SER A 283 | None | 1.40A | 1fm4A-4e5tA:undetectable | 1fm4A-4e5tA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4efc | ADENYLOSUCCINATELYASE (Trypanosomabrucei) |
PF00206(Lyase_1)PF08328(ASL_C) | 5 | PHE A 58PHE A 131PRO A 70SER A 126MET A 120 | None | 1.42A | 1fm4A-4efcA:undetectable | 1fm4A-4efcA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ggv | CYTOCHROME P450SUPERFAMILY PROTEIN (Streptomyceshimastatinicus) |
PF00067(p450) | 5 | PHE A 381PHE A 380PRO A 378THR A 372ILE A 124 | None | 1.30A | 1fm4A-4ggvA:undetectable | 1fm4A-4ggvA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihq | FLAI ATPASE (Sulfolobusacidocaldarius) |
PF00437(T2SSE) | 5 | PHE A 39PRO A 61PRO A 64THR A 65ILE A 72 | None | 1.47A | 1fm4A-4ihqA:undetectable | 1fm4A-4ihqA:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikv | DI-TRIPEPTIDE ABCTRANSPORTER(PERMEASE) (Geobacilluskaustophilus) |
PF00854(PTR2) | 5 | PHE A 275PRO A 271GLN A 448ALA A 303SER A 302 | None | 1.12A | 1fm4A-4ikvA:undetectable | 1fm4A-4ikvA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3q | CATECHOL OXIDASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 5 | PHE A 126THR A 114ILE A 365GLN A 105ALA A 360 | None | 1.45A | 1fm4A-4j3qA:undetectable | 1fm4A-4j3qA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4neg | TRYPTOPHAN SYNTHASEBETA CHAIN (Bacillusanthracis) |
PF00291(PALP) | 5 | PHE A 245PRO A 247PHE A 248PRO A 228GLN A 219 | None | 1.31A | 1fm4A-4negA:undetectable | 1fm4A-4negA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nji | 7-CARBOXY-7-DEAZAGUANINE SYNTHASE (Burkholderiamultivorans) |
PF13394(Fer4_14) | 5 | PHE A 167PHE A 170THR A 90ILE A 127GLN A 13 | NoneNone2K8 A 303 ( 2.9A)None2K8 A 303 (-3.4A) | 1.49A | 1fm4A-4njiA:undetectable | 1fm4A-4njiA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1i | AMINOBENZOYL-GLUTAMATE TRANSPORTER (Neisseriagonorrhoeae) |
PF03806(ABG_transport) | 5 | PHE A 30PHE A 367PRO A 95THR A 98ALA A 424 | None | 1.28A | 1fm4A-4r1iA:undetectable | 1fm4A-4r1iA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1i | AMINOBENZOYL-GLUTAMATE TRANSPORTER (Neisseriagonorrhoeae) |
PF03806(ABG_transport) | 5 | PHE A 30PHE A 367THR A 98GLN A 201ALA A 203 | None | 1.32A | 1fm4A-4r1iA:undetectable | 1fm4A-4r1iA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rh7 | GREEN FLUORESCENTPROTEIN/CYTOPLASMICDYNEIN 2 HEAVY CHAIN1 (Homo sapiens;syntheticconstruct) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | PHE A1788PHE A1740ILE A1761ALA A1736SER A1785 | None | 1.27A | 1fm4A-4rh7A:undetectable | 1fm4A-4rh7A:4.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbm | DELTA-LIKE PROTEIN 1 (Homo sapiens) |
PF01414(DSL)PF07657(MNNL) | 5 | PHE A 25PHE A 110PHE A 112PRO A 117SER A 121 | None | 1.22A | 1fm4A-4xbmA:undetectable | 1fm4A-4xbmA:14.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z3l | MAJOR POLLENALLERGEN BET V 1-A (Betula pendula) |
PF00407(Bet_v_1) | 8 | PHE A 58PHE A 62PHE A 64THR A 94ILE A 98TYR A 120SER A 136MET A 139 | NoneNoneSO4 A 202 (-4.8A)NoneNoneNoneNoneNone | 0.81A | 1fm4A-4z3lA:27.6 | 1fm4A-4z3lA:91.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z3l | MAJOR POLLENALLERGEN BET V 1-A (Betula pendula) |
PF00407(Bet_v_1) | 8 | PHE A 58PHE A 62PRO A 63PHE A 64THR A 94TYR A 120SER A 136MET A 139 | NoneNoneNoneSO4 A 202 (-4.8A)NoneNoneNoneNone | 0.87A | 1fm4A-4z3lA:27.6 | 1fm4A-4z3lA:91.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z3l | MAJOR POLLENALLERGEN BET V 1-A (Betula pendula) |
PF00407(Bet_v_1) | 8 | PHE A 58PHE A 64THR A 94ILE A 98TYR A 120ALA A 135SER A 136MET A 139 | NoneSO4 A 202 (-4.8A)NoneNoneNoneNoneNoneNone | 0.75A | 1fm4A-4z3lA:27.6 | 1fm4A-4z3lA:91.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4z3l | MAJOR POLLENALLERGEN BET V 1-A (Betula pendula) |
PF00407(Bet_v_1) | 8 | PHE A 58PRO A 63PHE A 64THR A 94TYR A 120ALA A 135SER A 136MET A 139 | NoneNoneSO4 A 202 (-4.8A)NoneNoneNoneNoneNone | 0.85A | 1fm4A-4z3lA:27.6 | 1fm4A-4z3lA:91.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z6k | ALCOHOLDEHYDROGENASE (Moraxella sp.TAE123) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | PRO A 55PHE A 57PRO A 59ILE A 316SER A 12 | None | 1.10A | 1fm4A-4z6kA:undetectable | 1fm4A-4z6kA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT ALPHAPROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT DELTA (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF01008(IF-2B)PF01008(IF-2B) | 5 | PRO A 254PHE A 253PRO G 451THR G 453ILE A 337 | None | 1.07A | 1fm4A-5b04A:undetectable | 1fm4A-5b04A:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bmo | PUTATIVEUNCHARACTERIZEDPROTEIN LNMX (Streptomycesatroolivaceus) |
PF02585(PIG-L) | 5 | PRO A 22ILE A 25TYR A 45ALA A 199SER A 196 | None | 1.40A | 1fm4A-5bmoA:undetectable | 1fm4A-5bmoA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d86 | PROBABLE SIDEROPHOREBIOSYNTHESIS PROTEINSBNA (Staphylococcusaureus) |
PF00291(PALP) | 5 | PRO A 235PHE A 152THR A 74SER A 189MET A 191 | NoneNoneNonePLP A1001 (-2.7A)None | 1.34A | 1fm4A-5d86A:undetectable | 1fm4A-5d86A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e78 | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00067(p450) | 5 | PHE A 393PRO A 392PRO A 358ILE A 433ALA A 321 | HEM A 501 (-4.5A)NoneNoneNoneNone | 1.41A | 1fm4A-5e78A:undetectable | 1fm4A-5e78A:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey5 | LBCA-B (syntheticconstruct) |
PF00291(PALP) | 5 | PHE B 238PRO B 240PHE B 241PRO B 221GLN B 212 | None | 1.30A | 1fm4A-5ey5B:undetectable | 1fm4A-5ey5B:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fic | SPHINGOMYELINPHOSPHODIESTERASE (Mus musculus) |
PF00149(Metallophos) | 5 | PHE A 478PHE A 453PRO A 426TYR A 438ALA A 475 | None | 1.14A | 1fm4A-5ficA:undetectable | 1fm4A-5ficA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h53 | SKELETAL MUSCLEMYOSIN HEAVY CHAINMYHC-EO/IIL (Oryctolaguscuniculus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | PHE A 366PRO A 377THR A 606TYR A 611ALA A 383 | None | 1.10A | 1fm4A-5h53A:undetectable | 1fm4A-5h53A:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ja1 | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | PHE A 824ILE A 601TYR A 599GLN A 617ALA A 619 | None | 1.41A | 1fm4A-5ja1A:2.4 | 1fm4A-5ja1A:7.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxu | DYP-TYPE PEROXIDASEFAMILY (Thermomonosporacurvata) |
PF04261(Dyp_perox) | 5 | PHE A 348PRO A 329THR A 120ILE A 387MET A 325 | HEM A 501 (-3.9A)NoneNoneNoneHEM A 501 (-3.5A) | 1.40A | 1fm4A-5jxuA:0.4 | 1fm4A-5jxuA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdr | ACETYL-COENZYME ACARBOXYLASE CARBOXYLTRANSFERASE SUBUNITALPHA (Staphylococcusaureus) |
PF03255(ACCA) | 5 | PHE A 283PHE A 151THR A 156TYR A 218ALA A 207 | None | 1.40A | 1fm4A-5kdrA:undetectable | 1fm4A-5kdrA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6u | BETA-MANNOSIDASE (Dictyoglomusthermophilum) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 5 | PHE A 722PHE A 703ILE A 573TYR A 569ALA A 758 | None | 1.39A | 1fm4A-5n6uA:undetectable | 1fm4A-5n6uA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nag | KYNURENINE3-MONOOXYGENASE (Pseudomonasfluorescens) |
PF01494(FAD_binding_3) | 5 | PHE A 131PHE A 36ILE A 163GLN A 32ALA A 127 | None | 1.00A | 1fm4A-5nagA:undetectable | 1fm4A-5nagA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5or4 | CATECHOL OXIDASE (Aspergillusoryzae) |
no annotation | 5 | PHE A 126THR A 114ILE A 365GLN A 105ALA A 360 | None | 1.40A | 1fm4A-5or4A:undetectable | 1fm4A-5or4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5svc | ACETONE CARBOXYLASEALPHA SUBUNIT (Xanthobacterautotrophicus) |
PF02538(Hydantoinase_B) | 5 | PHE A 652PRO A 585TYR A 621GLN A 503SER A 508 | None | 1.47A | 1fm4A-5svcA:undetectable | 1fm4A-5svcA:11.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | PHE A 677PRO A 599ILE A 836ALA A 609SER A 827 | None | 1.47A | 1fm4A-5um6A:undetectable | 1fm4A-5um6A:11.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x9u | THERMOSOME, ALPHASUBUNIT (Carboxydothermushydrogenoformans) |
no annotation | 5 | PRO A 426PHE A 394GLN A 81ALA A 488SER A 489 | None | 1.37A | 1fm4A-5x9uA:undetectable | 1fm4A-5x9uA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjy | ATP-BINDING CASSETTESUB-FAMILY A MEMBER1 (Homo sapiens) |
PF00005(ABC_tran)PF12698(ABC2_membrane_3) | 5 | THR A1401ILE A1613ALA A 64SER A 63MET A 61 | None | 1.09A | 1fm4A-5xjyA:undetectable | 1fm4A-5xjyA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bv2 | AMINOPEPTIDASE N (Sus scrofa) |
no annotation | 5 | PHE A 627PHE A 545ILE A 470SER A 477MET A 481 | None | 1.39A | 1fm4A-6bv2A:undetectable | 1fm4A-6bv2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fay | ODZ3 PROTEIN (Mus musculus) |
no annotation | 5 | PHE A2398PRO A2397THR A1879ILE A1896GLN A1892 | None | 1.18A | 1fm4A-6fayA:undetectable | 1fm4A-6fayA:undetectable |