SIMILAR PATTERNS OF AMINO ACIDS FOR 1FM4_A_DXCA1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT


(Escherichia
coli)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3)
5 PRO A 345
PHE A 348
PRO A 350
THR A 315
ILE A 230
None
1.39A 1fm4A-1c30A:
0.7
1fm4A-1c30A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cov COXSACKIEVIRUS COAT
PROTEIN


(Enterovirus B)
PF00073
(Rhv)
5 PHE 3  85
PRO 3  86
PHE 3 189
PRO 3 137
ILE 3 171
None
1.47A 1fm4A-1cov3:
0.0
1fm4A-1cov3:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens)
PF01291
(LIF_OSM)
5 PRO A  57
PHE A 176
THR A  21
ILE A 118
ALA A  76
None
1.00A 1fm4A-1evsA:
undetectable
1fm4A-1evsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2


(Escherichia
coli)
PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N)
5 PHE A 508
PRO A 509
THR A 179
ILE A 278
SER A 575
None
1.29A 1fm4A-1l5jA:
0.0
1fm4A-1l5jA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE
F1-ATPASE


(Bacillus sp.
PS3;
Bacillus sp.
PS3)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
5 PHE B 349
THR B 207
ILE E 358
ALA E 327
SER E 351
None
1.32A 1fm4A-1skyB:
0.0
1fm4A-1skyB:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1


(Pyrococcus
furiosus)
PF00291
(PALP)
5 PHE B 236
PRO B 238
PHE B 239
PRO B 219
GLN B 210
None
1.39A 1fm4A-1wdwB:
0.0
1fm4A-1wdwB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuv HYPOTHETICAL PROTEIN
MM0500


(Methanosarcina
mazei)
PF08327
(AHSA1)
5 PHE A 136
PHE A 102
ILE A 154
TYR A 158
SER A 132
None
1.29A 1fm4A-1xuvA:
13.8
1fm4A-1xuvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7l UBIQUITIN-ACTIVATING
ENZYME E1 1


(Mus musculus)
PF10585
(UBA_e1_thiolCys)
5 PRO A 638
ILE A 875
GLN A 646
ALA A 648
SER A 866
None
None
TBR  A 999 (-3.1A)
None
None
1.36A 1fm4A-1z7lA:
0.0
1fm4A-1z7lA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA


(Escherichia
coli)
PF02233
(PNTB)
5 PHE C 163
PHE C 164
PRO C 161
GLN C 123
ALA C 121
None
1.23A 1fm4A-2bruC:
0.0
1fm4A-2bruC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE


(Aquifex
aeolicus)
PF01208
(URO-D)
5 PHE A 237
PHE A 199
ILE A 264
TYR A 308
MET A  24
None
1.48A 1fm4A-2ejaA:
undetectable
1fm4A-2ejaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN


(Thermotoga
maritima)
PF13407
(Peripla_BP_4)
5 PHE A  86
PHE A  63
THR A  43
ILE A  72
ALA A  78
None
1.50A 1fm4A-2fn9A:
undetectable
1fm4A-2fn9A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2


(Salmonella
enterica)
PF04166
(PdxA)
5 PRO A 123
PRO A  18
THR A  43
ILE A  52
ALA A 302
None
1.49A 1fm4A-2hi1A:
undetectable
1fm4A-2hi1A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE


(Bos taurus)
PF03414
(Glyco_transf_6)
5 PHE A 234
PHE A 230
GLN A 247
ALA A 282
MET A 224
None
None
TRS  A1369 (-4.0A)
MN  A1367 ( 4.9A)
None
1.38A 1fm4A-2jcjA:
undetectable
1fm4A-2jcjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli)
PF01306
(LacY_symp)
5 PHE A  30
PHE A  29
PRO A  28
PHE A  27
ALA A 244
None
1.49A 1fm4A-2v8nA:
undetectable
1fm4A-2v8nA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh0 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE


(Escherichia
coli)
PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2)
5 PHE A  41
THR A  92
ALA A  34
SER A  33
MET A  31
None
1.24A 1fm4A-3eh0A:
undetectable
1fm4A-3eh0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE


(Gloeobacter
violaceus)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 PRO A 194
THR A 188
ILE A 184
ALA A 200
SER A 203
None
1.49A 1fm4A-3gd5A:
undetectable
1fm4A-3gd5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv9 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY


(Neisseria
meningitidis)
PF03466
(LysR_substrate)
5 PRO A 268
PHE A 165
PRO A 246
THR A 100
ILE A 232
None
1.44A 1fm4A-3jv9A:
undetectable
1fm4A-3jv9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9h PF-32 PROTEIN

(Borreliella
burgdorferi)
PF13614
(AAA_31)
5 PHE A 168
PHE A 169
THR A 131
ILE A 151
SER A 162
None
1.47A 1fm4A-3k9hA:
undetectable
1fm4A-3k9hA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR


(Citrobacter
freundii)
PF03466
(LysR_substrate)
5 PHE A 242
PRO A 254
ILE A 183
ALA A 228
MET A 224
None
1.08A 1fm4A-3kosA:
undetectable
1fm4A-3kosA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans)
PF00501
(AMP-binding)
5 PRO A 320
PHE A 291
PRO A 290
ALA A  26
MET A  28
None
1.40A 1fm4A-3l2kA:
undetectable
1fm4A-3l2kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans)
PF00501
(AMP-binding)
5 PRO A 320
PHE A 291
PRO A 290
ILE A  59
ALA A  26
None
1.41A 1fm4A-3l2kA:
undetectable
1fm4A-3l2kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsl PUTATIVE EXPORTED
PROTEIN


(Bordetella
bronchiseptica)
PF13379
(NMT1_2)
5 PHE A 238
PRO A 235
GLN A  79
ALA A  86
SER A  85
None
1.42A 1fm4A-3qslA:
undetectable
1fm4A-3qslA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwb PROBABLE QUINONE
OXIDOREDUCTASE


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 PHE A 290
ILE A 277
GLN A 132
ALA A 136
SER A 138
None
None
NDP  A 335 (-3.6A)
None
None
1.35A 1fm4A-3qwbA:
undetectable
1fm4A-3qwbA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE


(Thermotoga
maritima)
PF00544
(Pec_lyase_C)
5 PHE A 226
PRO A 227
PHE A 260
PRO A 262
MET A 253
None
1.30A 1fm4A-3zscA:
undetectable
1fm4A-3zscA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 PRO A 585
ILE A 354
TYR A 348
ALA A 501
SER A 500
None
0.97A 1fm4A-4c7vA:
undetectable
1fm4A-4c7vA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora)
PF02435
(Glyco_hydro_68)
5 PHE A  53
PRO A 206
PHE A 207
TYR A   4
ALA A 262
None
1.47A 1fm4A-4d47A:
undetectable
1fm4A-4d47A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE


(Sulfurisphaera
tokodaii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 PHE A  99
PHE A 104
PRO A 105
THR A 150
ALA A  10
None
1.11A 1fm4A-4dpkA:
undetectable
1fm4A-4dpkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN


(Labrenzia
alexandrii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 PRO A 247
PRO A 241
THR A 214
GLN A 286
SER A 283
None
1.40A 1fm4A-4e5tA:
undetectable
1fm4A-4e5tA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE


(Trypanosoma
brucei)
PF00206
(Lyase_1)
PF08328
(ASL_C)
5 PHE A  58
PHE A 131
PRO A  70
SER A 126
MET A 120
None
1.42A 1fm4A-4efcA:
undetectable
1fm4A-4efcA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN


(Streptomyces
himastatinicus)
PF00067
(p450)
5 PHE A 381
PHE A 380
PRO A 378
THR A 372
ILE A 124
None
1.30A 1fm4A-4ggvA:
undetectable
1fm4A-4ggvA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius)
PF00437
(T2SSE)
5 PHE A  39
PRO A  61
PRO A  64
THR A  65
ILE A  72
None
1.47A 1fm4A-4ihqA:
undetectable
1fm4A-4ihqA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)


(Geobacillus
kaustophilus)
PF00854
(PTR2)
5 PHE A 275
PRO A 271
GLN A 448
ALA A 303
SER A 302
None
1.12A 1fm4A-4ikvA:
undetectable
1fm4A-4ikvA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae)
PF00264
(Tyrosinase)
5 PHE A 126
THR A 114
ILE A 365
GLN A 105
ALA A 360
None
1.45A 1fm4A-4j3qA:
undetectable
1fm4A-4j3qA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4neg TRYPTOPHAN SYNTHASE
BETA CHAIN


(Bacillus
anthracis)
PF00291
(PALP)
5 PHE A 245
PRO A 247
PHE A 248
PRO A 228
GLN A 219
None
1.31A 1fm4A-4negA:
undetectable
1fm4A-4negA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nji 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE


(Burkholderia
multivorans)
PF13394
(Fer4_14)
5 PHE A 167
PHE A 170
THR A  90
ILE A 127
GLN A  13
None
None
2K8  A 303 ( 2.9A)
None
2K8  A 303 (-3.4A)
1.49A 1fm4A-4njiA:
undetectable
1fm4A-4njiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER


(Neisseria
gonorrhoeae)
PF03806
(ABG_transport)
5 PHE A  30
PHE A 367
PRO A  95
THR A  98
ALA A 424
None
1.28A 1fm4A-4r1iA:
undetectable
1fm4A-4r1iA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER


(Neisseria
gonorrhoeae)
PF03806
(ABG_transport)
5 PHE A  30
PHE A 367
THR A  98
GLN A 201
ALA A 203
None
1.32A 1fm4A-4r1iA:
undetectable
1fm4A-4r1iA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1


(Homo sapiens;
synthetic
construct)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 PHE A1788
PHE A1740
ILE A1761
ALA A1736
SER A1785
None
1.27A 1fm4A-4rh7A:
undetectable
1fm4A-4rh7A:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbm DELTA-LIKE PROTEIN 1

(Homo sapiens)
PF01414
(DSL)
PF07657
(MNNL)
5 PHE A  25
PHE A 110
PHE A 112
PRO A 117
SER A 121
None
1.22A 1fm4A-4xbmA:
undetectable
1fm4A-4xbmA:
14.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A


(Betula pendula)
PF00407
(Bet_v_1)
8 PHE A  58
PHE A  62
PHE A  64
THR A  94
ILE A  98
TYR A 120
SER A 136
MET A 139
None
None
SO4  A 202 (-4.8A)
None
None
None
None
None
0.81A 1fm4A-4z3lA:
27.6
1fm4A-4z3lA:
91.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A


(Betula pendula)
PF00407
(Bet_v_1)
8 PHE A  58
PHE A  62
PRO A  63
PHE A  64
THR A  94
TYR A 120
SER A 136
MET A 139
None
None
None
SO4  A 202 (-4.8A)
None
None
None
None
0.87A 1fm4A-4z3lA:
27.6
1fm4A-4z3lA:
91.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A


(Betula pendula)
PF00407
(Bet_v_1)
8 PHE A  58
PHE A  64
THR A  94
ILE A  98
TYR A 120
ALA A 135
SER A 136
MET A 139
None
SO4  A 202 (-4.8A)
None
None
None
None
None
None
0.75A 1fm4A-4z3lA:
27.6
1fm4A-4z3lA:
91.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z3l MAJOR POLLEN
ALLERGEN BET V 1-A


(Betula pendula)
PF00407
(Bet_v_1)
8 PHE A  58
PRO A  63
PHE A  64
THR A  94
TYR A 120
ALA A 135
SER A 136
MET A 139
None
None
SO4  A 202 (-4.8A)
None
None
None
None
None
0.85A 1fm4A-4z3lA:
27.6
1fm4A-4z3lA:
91.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE


(Moraxella sp.
TAE123)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 PRO A  55
PHE A  57
PRO A  59
ILE A 316
SER A  12
None
1.10A 1fm4A-4z6kA:
undetectable
1fm4A-4z6kA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF01008
(IF-2B)
PF01008
(IF-2B)
5 PRO A 254
PHE A 253
PRO G 451
THR G 453
ILE A 337
None
1.07A 1fm4A-5b04A:
undetectable
1fm4A-5b04A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX


(Streptomyces
atroolivaceus)
PF02585
(PIG-L)
5 PRO A  22
ILE A  25
TYR A  45
ALA A 199
SER A 196
None
1.40A 1fm4A-5bmoA:
undetectable
1fm4A-5bmoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA


(Staphylococcus
aureus)
PF00291
(PALP)
5 PRO A 235
PHE A 152
THR A  74
SER A 189
MET A 191
None
None
None
PLP  A1001 (-2.7A)
None
1.34A 1fm4A-5d86A:
undetectable
1fm4A-5d86A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
5 PHE A 393
PRO A 392
PRO A 358
ILE A 433
ALA A 321
HEM  A 501 (-4.5A)
None
None
None
None
1.41A 1fm4A-5e78A:
undetectable
1fm4A-5e78A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct)
PF00291
(PALP)
5 PHE B 238
PRO B 240
PHE B 241
PRO B 221
GLN B 212
None
1.30A 1fm4A-5ey5B:
undetectable
1fm4A-5ey5B:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE


(Mus musculus)
PF00149
(Metallophos)
5 PHE A 478
PHE A 453
PRO A 426
TYR A 438
ALA A 475
None
1.14A 1fm4A-5ficA:
undetectable
1fm4A-5ficA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL


(Oryctolagus
cuniculus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 PHE A 366
PRO A 377
THR A 606
TYR A 611
ALA A 383
None
1.10A 1fm4A-5h53A:
undetectable
1fm4A-5h53A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 PHE A 824
ILE A 601
TYR A 599
GLN A 617
ALA A 619
None
1.41A 1fm4A-5ja1A:
2.4
1fm4A-5ja1A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY


(Thermomonospora
curvata)
PF04261
(Dyp_perox)
5 PHE A 348
PRO A 329
THR A 120
ILE A 387
MET A 325
HEM  A 501 (-3.9A)
None
None
None
HEM  A 501 (-3.5A)
1.40A 1fm4A-5jxuA:
0.4
1fm4A-5jxuA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA


(Staphylococcus
aureus)
PF03255
(ACCA)
5 PHE A 283
PHE A 151
THR A 156
TYR A 218
ALA A 207
None
1.40A 1fm4A-5kdrA:
undetectable
1fm4A-5kdrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
5 PHE A 722
PHE A 703
ILE A 573
TYR A 569
ALA A 758
None
1.39A 1fm4A-5n6uA:
undetectable
1fm4A-5n6uA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE


(Pseudomonas
fluorescens)
PF01494
(FAD_binding_3)
5 PHE A 131
PHE A  36
ILE A 163
GLN A  32
ALA A 127
None
1.00A 1fm4A-5nagA:
undetectable
1fm4A-5nagA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae)
no annotation 5 PHE A 126
THR A 114
ILE A 365
GLN A 105
ALA A 360
None
1.40A 1fm4A-5or4A:
undetectable
1fm4A-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT


(Xanthobacter
autotrophicus)
PF02538
(Hydantoinase_B)
5 PHE A 652
PRO A 585
TYR A 621
GLN A 503
SER A 508
None
1.47A 1fm4A-5svcA:
undetectable
1fm4A-5svcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1


(Schizosaccharomyces
pombe)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
5 PHE A 677
PRO A 599
ILE A 836
ALA A 609
SER A 827
None
1.47A 1fm4A-5um6A:
undetectable
1fm4A-5um6A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9u THERMOSOME, ALPHA
SUBUNIT


(Carboxydothermus
hydrogenoformans)
no annotation 5 PRO A 426
PHE A 394
GLN A  81
ALA A 488
SER A 489
None
1.37A 1fm4A-5x9uA:
undetectable
1fm4A-5x9uA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1


(Homo sapiens)
PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3)
5 THR A1401
ILE A1613
ALA A  64
SER A  63
MET A  61
None
1.09A 1fm4A-5xjyA:
undetectable
1fm4A-5xjyA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa)
no annotation 5 PHE A 627
PHE A 545
ILE A 470
SER A 477
MET A 481
None
1.39A 1fm4A-6bv2A:
undetectable
1fm4A-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus)
no annotation 5 PHE A2398
PRO A2397
THR A1879
ILE A1896
GLN A1892
None
1.18A 1fm4A-6fayA:
undetectable
1fm4A-6fayA:
undetectable