SIMILAR PATTERNS OF AMINO ACIDS FOR 1FKP_A_NVPA999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnv CONCANAVALIN B

(Canavalia
ensiformis) 		PF00704
(Glyco_hydro_18) 		5 PRO A 117
ASN A  60
VAL A  58
GLY A  59
LEU A  50
 None
 1.15A 1fkpA-1cnvA:
undetectable		 1fkpA-1cnvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I GAMMA
SUBUNIT

(Methanopyrus
kandleri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 PRO C  25
ASN B 318
VAL C 116
TYR C 113
GLY C 115
 None
 1.30A 1fkpA-1e6vC:
0.8		 1fkpA-1e6vC:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		5 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.14A 1fkpA-1f2pA:
undetectable		 1fkpA-1f2pA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		5 LEU A 159
VAL A  78
TYR A  54
GLY A  46
LEU A  83
 None
 1.13A 1fkpA-1fztA:
undetectable		 1fkpA-1fztA:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		5 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
 None
 0.48A 1fkpA-1harA:
13.2		 1fkpA-1harA:
93.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 LEU A 496
ASN A 498
TYR A 493
GLY A 239
LEU A 372
 None
None
None
MAY  A 600 (-3.6A)
MAY  A 600 (-4.6A)
 1.40A 1fkpA-1mt5A:
undetectable		 1fkpA-1mt5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.06A 1fkpA-1oypA:
undetectable		 1fkpA-1oypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 0.99A 1fkpA-1udqA:
undetectable		 1fkpA-1udqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 PRO A  39
LEU A  41
VAL A 158
TYR A 176
GLY A 157
 None
 1.38A 1fkpA-1uzgA:
undetectable		 1fkpA-1uzgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		5 PRO A 211
VAL A 231
TYR A   3
GLY A  83
TYR A  17
 None
 1.37A 1fkpA-1vzyA:
undetectable		 1fkpA-1vzyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1weh CONSERVED
HYPOTHETICAL PROTEIN
TT1887

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		5 VAL A  52
VAL A  23
TYR A  25
GLY A  51
LEU A   4
 None
 1.38A 1fkpA-1wehA:
undetectable		 1fkpA-1wehA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 PRO A 356
ASN A 319
VAL A 315
TYR A 311
GLY A 316
 None
 1.06A 1fkpA-1wzaA:
undetectable		 1fkpA-1wzaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		5 PRO A 356
VAL A 315
TYR A 308
TYR A 311
GLY A 316
 None
 0.97A 1fkpA-1wzaA:
undetectable		 1fkpA-1wzaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxg ENTEROTOXIN

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 PRO A 206
LEU A  28
TYR A  87
GLY A  84
TYR A  29
 None
 1.33A 1fkpA-1xxgA:
undetectable		 1fkpA-1xxgA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU A  72
VAL A 117
VAL A  12
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
None
 1.27A 1fkpA-1yhuA:
undetectable		 1fkpA-1yhuA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A  60
VAL A  87
GLY A  88
LEU A  12
TYR A  44
 GOL  A1272 (-4.0A)
None
GOL  A1271 (-3.8A)
None
None
 1.17A 1fkpA-1yq9A:
undetectable		 1fkpA-1yq9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 632
VAL A 540
TYR A 625
GLY A 622
TRP A 653
 None
 1.24A 1fkpA-1z68A:
undetectable		 1fkpA-1z68A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 LEU A  27
ASN A  25
VAL A 340
GLY A 341
LEU A   8
 None
 1.43A 1fkpA-2b3xA:
undetectable		 1fkpA-2b3xA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		5 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.40A 1fkpA-2c6rA:
undetectable		 1fkpA-2c6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 ASN A 293
TYR A 288
GLY A 278
LEU A 271
TYR A 292
 None
 1.31A 1fkpA-2e8yA:
undetectable		 1fkpA-2e8yA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A 151
LEU A 152
VAL A 314
GLY A 312
LEU A 141
 None
 1.38A 1fkpA-2eerA:
2.7		 1fkpA-2eerA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		5 PRO A 152
VAL A 232
VAL A 177
GLY A 212
LEU A  98
 None
 1.10A 1fkpA-2ekcA:
undetectable		 1fkpA-2ekcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5r MSTRAWBERRY

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.36A 1fkpA-2h5rA:
undetectable		 1fkpA-2h5rA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8q RED FLUORESCENT
PROTEIN DRFP583

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.37A 1fkpA-2h8qA:
undetectable		 1fkpA-2h8qA:
17.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
VAL A 179
TYR A 181
GLY A 190
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.3A)
 1.33A 1fkpA-2hnzA:
35.9		 1fkpA-2hnzA:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 PRO A  95
LEU A 100
VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
LEU A 234
TYR A 318
 PC0  A 999 ( 4.9A)
PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.54A 1fkpA-2hnzA:
35.9		 1fkpA-2hnzA:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 130
VAL A 148
VAL A 230
GLY A 147
TYR A 196
 None
 1.23A 1fkpA-2ix4A:
undetectable		 1fkpA-2ix4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		5 ASN A 193
VAL A 196
TYR A  58
TYR A  61
GLY A 195
 None
 1.24A 1fkpA-2o8sA:
undetectable		 1fkpA-2o8sA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		5 PRO A 192
ASN A  81
GLY A  80
TRP A  52
LEU A 207
 None
 1.10A 1fkpA-2q8nA:
undetectable		 1fkpA-2q8nA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0p TYPE 2A
PHOSPHATASE-ASSOCIAT
ED PROTEIN 42

(Saccharomyces
cerevisiae) 		PF04177
(TAP42) 		5 PRO A 141
LEU A 146
VAL A 128
GLY A 129
TYR A 147
 None
 1.33A 1fkpA-2v0pA:
undetectable		 1fkpA-2v0pA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vad RED FLUORESCENT
PROTEIN

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.34A 1fkpA-2vadA:
undetectable		 1fkpA-2vadA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6

(Homo sapiens) 		PF00651
(BTB) 		5 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.11A 1fkpA-2vkpA:
undetectable		 1fkpA-2vkpA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PRO A  62
LEU A   4
TYR A  60
GLY A  51
LEU A  35
 None
 1.38A 1fkpA-2wskA:
undetectable		 1fkpA-2wskA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		5 PRO F 373
LEU F 334
VAL F 287
TYR F 289
LEU F 361
 None
 1.31A 1fkpA-2xwbF:
undetectable		 1fkpA-2xwbF:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 TYR A 729
TYR A 726
TRP A 578
LEU A 648
TYR A 571
 None
 1.18A 1fkpA-2y8nA:
undetectable		 1fkpA-2y8nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN

(Aeropyrum
pernix) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A  26
VAL A 131
VAL A  31
GLY A 135
LEU A  39
 None
 1.28A 1fkpA-3a5wA:
undetectable		 1fkpA-3a5wA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a77 INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		5 PRO A 248
LEU A 265
VAL A 348
GLY A 349
LEU A 245
 None
 1.30A 1fkpA-3a77A:
undetectable		 1fkpA-3a77A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.02A 1fkpA-3b4tA:
undetectable		 1fkpA-3b4tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A  32
VAL A  90
VAL A  43
TYR A  40
GLY A  72
 None
 1.36A 1fkpA-3b70A:
undetectable		 1fkpA-3b70A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgd PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE,
CLASS I

(Bacillus
anthracis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 335
VAL A 398
TYR A 375
GLY A 397
LEU A 337
 None
 1.35A 1fkpA-3cgdA:
undetectable		 1fkpA-3cgdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 PRO A 403
LEU A 389
VAL A  63
GLY A  67
LEU A 455
 None
 1.20A 1fkpA-3cp2A:
undetectable		 1fkpA-3cp2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.09A 1fkpA-3dd6A:
undetectable		 1fkpA-3dd6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 PRO A 173
LEU A 187
VAL A 147
TYR A 171
GLY A 146
 None
 1.44A 1fkpA-3ddnA:
undetectable		 1fkpA-3ddnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		5 LEU A  61
VAL A  46
VAL A   6
TYR A  28
GLY A  30
 None
 1.23A 1fkpA-3dqpA:
undetectable		 1fkpA-3dqpA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 LEU L 273
VAL L 261
VAL L 328
TYR L 256
GLY L 254
 None
 1.15A 1fkpA-3g9kL:
undetectable		 1fkpA-3g9kL:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7v O-SUCCINYLBENZOATE
SYNTHASE

(Thermosynechococcus
elongatus) 		PF13378
(MR_MLE_C) 		5 LEU A 162
ASN A 187
GLY A 186
TRP A 135
LEU A 152
 None
 1.40A 1fkpA-3h7vA:
undetectable		 1fkpA-3h7vA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF06094
(GGACT) 		5 PRO A  51
VAL A  63
TYR A 137
GLY A  65
LEU A  10
 PCA  A1001 (-4.1A)
None
NO3  A 154 (-4.8A)
None
PCA  A1001 (-3.7A)
 1.26A 1fkpA-3jucA:
undetectable		 1fkpA-3jucA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		5 ASN A 190
VAL A  30
VAL A  35
GLY A  31
LEU A 165
 ADP  A 301 (-2.9A)
ADP  A 301 (-4.4A)
None
ADP  A 301 (-3.1A)
None
 1.37A 1fkpA-3kb1A:
undetectable		 1fkpA-3kb1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf4 FLUORESCENT TIMER
PRECURSOR BLUE102

(Discosoma sp.) 		PF01353
(GFP) 		5 LEU A  61
VAL A  22
VAL B 105
GLY B 126
LEU A  54
 None
 1.34A 1fkpA-3lf4A:
undetectable		 1fkpA-3lf4A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 PRO A 774
LEU A 778
VAL A 909
GLY A 907
LEU A 979
 None
 1.29A 1fkpA-3lj0A:
undetectable		 1fkpA-3lj0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.34A 1fkpA-3ov3A:
undetectable		 1fkpA-3ov3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p56 RIBONUCLEASE H2
SUBUNIT A

(Homo sapiens) 		PF01351
(RNase_HII) 		5 LEU A 153
VAL A  33
VAL A 138
GLY A  32
TYR A 149
 None
 1.29A 1fkpA-3p56A:
2.8		 1fkpA-3p56A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 LEU A  18
ASN A 102
VAL A 101
GLY A 103
LEU A  53
 None
 1.25A 1fkpA-3qxzA:
undetectable		 1fkpA-3qxzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		5 LEU A  45
VAL A 202
VAL A 114
TYR A 182
GLY A 184
 None
 1.40A 1fkpA-3raoA:
undetectable		 1fkpA-3raoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		5 PRO I  34
LEU J 561
VAL I  66
VAL I 180
GLY I  67
 None
 1.15A 1fkpA-3s88I:
undetectable		 1fkpA-3s88I:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sei CASKIN-1

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU A  21
ASN A  25
VAL A  49
GLY A  48
LEU A  19
 None
 1.12A 1fkpA-3seiA:
undetectable		 1fkpA-3seiA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sen CASKIN-1

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU A  24
ASN A  28
VAL A  52
GLY A  51
LEU A  22
 None
 1.10A 1fkpA-3senA:
undetectable		 1fkpA-3senA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 PRO C  21
ASN B 313
VAL C 112
TYR C 109
GLY C 111
 None
None
None
GOL  C 281 (-4.6A)
None
 1.24A 1fkpA-3sqgC:
undetectable		 1fkpA-3sqgC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy6 FIMBRIAL PROTEIN
BF1861

(Bacteroides
fragilis) 		PF13149
(Mfa_like_1) 		5 LEU A 116
ASN A  69
TYR A 131
GLY A  55
TYR A 107
 None
 1.40A 1fkpA-3sy6A:
undetectable		 1fkpA-3sy6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		5 LEU A 231
ASN A 157
VAL A 144
GLY A 155
LEU A 235
 None
 1.34A 1fkpA-3uoeA:
undetectable		 1fkpA-3uoeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 LEU A 155
VAL A 113
VAL A  96
TYR A 102
TYR A 153
 None
 1.26A 1fkpA-3va6A:
undetectable		 1fkpA-3va6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.45A 1fkpA-3vreB:
undetectable		 1fkpA-3vreB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		5 PRO A 154
LEU A 137
VAL A 166
VAL A 126
LEU A 192
 None
 1.34A 1fkpA-4cg1A:
undetectable		 1fkpA-4cg1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 LEU C  18
ASN C 107
VAL C 106
GLY C 108
LEU C  53
 None
 1.20A 1fkpA-4fzwC:
undetectable		 1fkpA-4fzwC:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.28A 1fkpA-4jggA:
undetectable		 1fkpA-4jggA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		5 LEU A 180
VAL A  87
VAL A 420
GLY A 165
TYR A 182
 None
 1.31A 1fkpA-4jndA:
undetectable		 1fkpA-4jndA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxb INVASION-ASSOCIATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		5 LEU A  96
VAL A 108
GLY A 109
LEU A 167
TYR A  91
 None
 1.12A 1fkpA-4jxbA:
undetectable		 1fkpA-4jxbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 PRO A 122
VAL A 293
VAL A 288
GLY A 287
LEU A 107
 None
 1.06A 1fkpA-4lvqA:
undetectable		 1fkpA-4lvqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		5 LEU A 192
VAL A 168
VAL A 166
GLY A 167
TYR A 194
 None
 1.41A 1fkpA-4maeA:
undetectable		 1fkpA-4maeA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 LEU A 467
ASN A 430
VAL A 404
GLY A 411
LEU A 475
 None
 1.39A 1fkpA-4nk6A:
undetectable		 1fkpA-4nk6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		5 LEU A 467
ASN A 430
VAL A 404
GLY A 411
LEU A 475
 None
 1.41A 1fkpA-4ozyA:
undetectable		 1fkpA-4ozyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		5 PRO A 384
LEU A 279
VAL A 243
GLY A 257
LEU A 283
 None
 1.30A 1fkpA-4r9iA:
undetectable		 1fkpA-4r9iA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		5 LEU A 153
ASN A 158
TYR A 151
GLY A 160
LEU A 663
 None
 1.35A 1fkpA-4s3pA:
undetectable		 1fkpA-4s3pA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
 None
 1.35A 1fkpA-4xiiA:
undetectable		 1fkpA-4xiiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE

(Thermus
thermophilus) 		PF00571
(CBS) 		5 PRO A  11
LEU A 117
VAL A  85
VAL A  37
GLY A  45
 None
 1.25A 1fkpA-5aweA:
3.0		 1fkpA-5aweA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 PRO A 503
LEU A 575
VAL A 531
VAL A 520
TYR A 564
 None
 1.43A 1fkpA-5azaA:
undetectable		 1fkpA-5azaA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 VAL B 106
VAL B 179
TYR B 181
TYR B 188
GLY B 190
 None
 0.34A 1fkpA-5c24B:
6.9		 1fkpA-5c24B:
96.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5g SPHERULIN-4

(Aspergillus
clavatus) 		PF12138
(Spherulin4) 		5 PRO A  68
LEU A  64
TYR A 108
GLY A 125
LEU A 115
 None
EDO  A 402 ( 4.1A)
None
None
None
 1.44A 1fkpA-5c5gA:
undetectable		 1fkpA-5c5gA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ

(Salmonella
enterica) 		PF01832
(Glucosaminidase) 		5 PRO A 162
LEU A 178
VAL A 203
GLY A 188
LEU A 156
 IOD  A 401 ( 4.5A)
None
None
None
None
 1.38A 1fkpA-5dn5A:
undetectable		 1fkpA-5dn5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		5 PRO A 106
VAL A 394
TYR A 312
GLY A 384
TYR A 410
 None
 1.32A 1fkpA-5i6zA:
undetectable		 1fkpA-5i6zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 PRO B 642
LEU B 655
VAL B 680
GLY B 682
LEU B 647
 None
 1.05A 1fkpA-5ldrB:
undetectable		 1fkpA-5ldrB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 285
VAL A  46
VAL A  57
TYR A  60
LEU A  36
 None
 1.28A 1fkpA-5ll7A:
undetectable		 1fkpA-5ll7A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 ASN A 219
VAL A 195
VAL A 294
GLY A 204
TYR A 272
 None
 1.19A 1fkpA-5lmzA:
undetectable		 1fkpA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 LEU A 273
ASN A 219
VAL A 195
VAL A 294
GLY A 204
 None
 1.17A 1fkpA-5lmzA:
undetectable		 1fkpA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
 None
 1.39A 1fkpA-5mg5A:
undetectable		 1fkpA-5mg5A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 5 PRO A  69
LEU A  15
VAL A  78
VAL A  30
LEU A  93
 None
 1.25A 1fkpA-5o25A:
2.1		 1fkpA-5o25A:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 PRO A  94
LEU A  99
TRP A 228
LEU A 233
TYR A 317
 None
 1.25A 1fkpA-5ovnA:
26.0		 1fkpA-5ovnA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 PRO A  94
LEU A  99
VAL A 105
GLY A 189
TYR A 317
 None
 0.92A 1fkpA-5ovnA:
26.0		 1fkpA-5ovnA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 PRO A  94
LEU A  99
VAL A 105
LEU A 233
TYR A 317
 None
 1.04A 1fkpA-5ovnA:
26.0		 1fkpA-5ovnA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 5 PRO A 232
LEU A 234
VAL A 203
LEU A 279
TYR A 236
 None
 1.33A 1fkpA-5tu4A:
undetectable		 1fkpA-5tu4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 5 PRO C 427
VAL C 348
VAL C 370
GLY C 345
LEU C 457
 None
 1.41A 1fkpA-5v12C:
2.2		 1fkpA-5v12C:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		5 LEU A 164
VAL A 312
VAL A 153
GLY A 177
LEU A 331
 None
 1.26A 1fkpA-5w8oA:
undetectable		 1fkpA-5w8oA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 LEU A 634
ASN A 640
VAL A 588
TYR A 584
LEU A 642
 None
 1.17A 1fkpA-5wvgA:
undetectable		 1fkpA-5wvgA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 5 LEU A 314
VAL A  25
VAL A 348
GLY A 350
LEU A 312
 None
 1.23A 1fkpA-5z67A:
undetectable		 1fkpA-5z67A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 5 PRO A 165
LEU A 133
VAL A 122
GLY A 123
TRP A 163
 None
 1.43A 1fkpA-6avyA:
undetectable		 1fkpA-6avyA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 5 LEU A 195
VAL A 181
GLY A 151
LEU A 154
TYR A 224
 None
 1.42A 1fkpA-6b7kA:
undetectable		 1fkpA-6b7kA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgk -

(-) 		no annotation 5 LEU A 115
ASN A 176
VAL A 180
GLY A 179
LEU A 144
 None
 1.42A 1fkpA-6dgkA:
undetectable		 1fkpA-6dgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU I 284
VAL I 236
TYR I 234
GLY I 262
TYR I   9
 None
 1.40A 1fkpA-6esqI:
undetectable		 1fkpA-6esqI:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fzw COLLAGEN
ALPHA-1(III) CHAIN

(Homo sapiens) 		no annotation 5 PRO A 225
VAL A 239
VAL A  89
TYR A 149
LEU A 171
 None
 1.41A 1fkpA-6fzwA:
undetectable		 1fkpA-6fzwA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gw5 -

(-) 		no annotation 5 PRO A 232
LEU A 238
VAL A  93
TYR A 100
GLY A  95
 None
 1.37A 1fkpA-6gw5A:
undetectable		 1fkpA-6gw5A:
undetectable