SIMILAR PATTERNS OF AMINO ACIDS FOR 1FKO_A_EFZA999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.99A 1fkoA-1oypA:
undetectable		 1fkoA-1oypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 LEU A 798
VAL A 667
TYR A 671
GLY A 733
LEU A 726
 None
 1.45A 1fkoA-1qb4A:
2.8		 1fkoA-1qb4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 LEU A  54
VAL A  80
TYR A  25
TYR A  24
LEU A 222
 None
 1.43A 1fkoA-1slmA:
undetectable		 1fkoA-1slmA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A  32
VAL A 361
TYR A 366
TYR A 363
LEU A  25
 None
 1.29A 1fkoA-1ud3A:
0.5		 1fkoA-1ud3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 0.93A 1fkoA-1udqA:
undetectable		 1fkoA-1udqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		5 VAL A 160
VAL A 163
TYR A 241
GLY A 161
LEU A 322
 None
 1.32A 1fkoA-1udxA:
undetectable		 1fkoA-1udxA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 LEU A  14
ASN A 102
VAL A 101
GLY A 103
LEU A  49
 None
 1.32A 1fkoA-1uiyA:
undetectable		 1fkoA-1uiyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		5 LEU A  86
VAL A  60
VAL A 104
TYR A 101
GLY A  61
 None
 0.99A 1fkoA-1vqvA:
0.6		 1fkoA-1vqvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 143
VAL A  95
TYR A  81
GLY A  79
LEU A 132
 None
 1.15A 1fkoA-1w78A:
0.6		 1fkoA-1w78A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfm SYNAPTOTAGMIN XIII

(Homo sapiens) 		PF00168
(C2) 		5 LEU A 111
VAL A  48
VAL A  30
TYR A  17
LEU A 130
 None
 1.38A 1fkoA-1wfmA:
undetectable		 1fkoA-1wfmA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz8 ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		5 LEU A 120
VAL A 111
VAL A 114
TRP A 156
LEU A 124
 None
 1.35A 1fkoA-1wz8A:
undetectable		 1fkoA-1wz8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		5 LEU A 261
VAL A  34
VAL A  58
LEU A  22
TYR A 260
 None
 1.11A 1fkoA-1y9uA:
undetectable		 1fkoA-1y9uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A  60
VAL A  87
GLY A  88
LEU A  12
TYR A  44
 GOL  A1272 (-4.0A)
None
GOL  A1271 (-3.8A)
None
None
 1.23A 1fkoA-1yq9A:
undetectable		 1fkoA-1yq9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		5 LEU A  79
ASN A  77
VAL A 128
GLY A 129
LEU A  60
 None
 1.46A 1fkoA-2bszA:
undetectable		 1fkoA-2bszA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE

(Streptomyces
cattleya) 		PF01887
(SAM_adeno_trans) 		5 LEU A 273
ASN A 219
VAL A 195
GLY A 204
LEU A 225
 None
 1.20A 1fkoA-2c4tA:
undetectable		 1fkoA-2c4tA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 396
VAL A 370
VAL A 368
GLY A 369
LEU A 400
 None
 1.20A 1fkoA-2dsjA:
undetectable		 1fkoA-2dsjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 LEU A 439
ASN A 368
VAL A 372
TRP A 437
LEU A 407
 None
 1.42A 1fkoA-2e8yA:
undetectable		 1fkoA-2e8yA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		7 LEU A 100
VAL A 106
VAL A 179
TYR A 188
GLY A 190
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.67A 1fkoA-2hnzA:
36.4		 1fkoA-2hnzA:
99.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
VAL A 179
TYR A 181
GLY A 190
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.3A)
 1.20A 1fkoA-2hnzA:
36.4		 1fkoA-2hnzA:
99.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kmc FERMITIN FAMILY
HOMOLOG 1

(Mus musculus) 		no annotation 5 LEU A  70
VAL A  42
GLY A  40
TRP A  63
LEU A  88
 None
 1.40A 1fkoA-2kmcA:
undetectable		 1fkoA-2kmcA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2o UPF0727 PROTEIN
C6ORF115

(Homo sapiens) 		PF14705
(Costars) 		5 LEU A  50
VAL A  28
VAL A  74
TYR A  61
LEU A  10
 None
 1.41A 1fkoA-2l2oA:
undetectable		 1fkoA-2l2oA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  81
VAL A 120
TYR A 119
TYR A 114
GLY A 117
 None
 1.44A 1fkoA-2nqlA:
undetectable		 1fkoA-2nqlA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 LEU A 593
VAL A 610
VAL A 581
TYR A 589
GLY A 583
 None
 1.46A 1fkoA-2ozuA:
undetectable		 1fkoA-2ozuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pid TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 LEU A 224
TYR A 177
GLY A 114
LEU A 119
TYR A 221
 None
None
None
None
YSA  A 384 (-4.7A)
 1.40A 1fkoA-2pidA:
undetectable		 1fkoA-2pidA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		5 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.09A 1fkoA-2qjoA:
undetectable		 1fkoA-2qjoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		5 LEU A  72
VAL A 178
TYR A 183
GLY A 177
LEU A  78
 None
 1.47A 1fkoA-2qmiA:
undetectable		 1fkoA-2qmiA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rr8 IQGAP1 PROTEIN

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  72
VAL A 116
VAL A  76
TYR A  77
GLY A  75
 None
 1.29A 1fkoA-2rr8A:
undetectable		 1fkoA-2rr8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 271
ASN A 273
VAL A 333
VAL A 337
LEU A 400
 None
 1.45A 1fkoA-2wdwA:
1.8		 1fkoA-2wdwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 LEU A 263
VAL A 280
VAL A 251
TYR A 259
GLY A 253
 None
 1.47A 1fkoA-2y0mA:
undetectable		 1fkoA-2y0mA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		5 ASN A 455
VAL A 453
TYR A 764
GLY A 454
LEU A 529
 PEG  A1797 ( 4.3A)
None
None
None
None
 1.02A 1fkoA-2y6iA:
2.4		 1fkoA-2y6iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 377
VAL A 401
TYR A 361
GLY A 370
TYR A 408
 None
 1.40A 1fkoA-2yjqA:
undetectable		 1fkoA-2yjqA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv4 HYPOTHETICAL PROTEIN
PH0435

(Pyrococcus
horikoshii) 		PF03481
(SUA5) 		5 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.19A 1fkoA-2yv4A:
undetectable		 1fkoA-2yv4A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
 None
 1.16A 1fkoA-2znsA:
undetectable		 1fkoA-2znsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 0.93A 1fkoA-3b4tA:
undetectable		 1fkoA-3b4tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		5 ASN A 133
VAL A  20
VAL A  25
GLY A  21
LEU A  97
 GNP  A 195 (-3.2A)
GNP  A 195 ( 4.1A)
None
GNP  A 195 (-3.3A)
None
 1.34A 1fkoA-3bc1A:
undetectable		 1fkoA-3bc1A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn7 FERREDOXIN-LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF07876
(Dabb) 		5 LEU A  22
VAL A  42
VAL A  40
GLY A  41
LEU A  10
 None
 1.29A 1fkoA-3bn7A:
4.8		 1fkoA-3bn7A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		5 ASN A 275
VAL A  49
GLY A 214
LEU A 160
TYR A 279
 None
CL  A 287 ( 4.1A)
None
None
None
 1.20A 1fkoA-3dclA:
undetectable		 1fkoA-3dclA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 0.98A 1fkoA-3dd6A:
undetectable		 1fkoA-3dd6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 196
VAL A  24
VAL A  17
GLY A 189
LEU A  99
 None
 1.18A 1fkoA-3eoqA:
3.6		 1fkoA-3eoqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh9 HEMOGLOBIN ALPHA
CHAIN

(Pteropus
giganteus) 		PF00042
(Globin) 		5 LEU A 105
VAL A  21
VAL A  62
GLY A  63
LEU A 109
 None
None
HEM  A 142 (-4.0A)
None
None
 1.38A 1fkoA-3fh9A:
undetectable		 1fkoA-3fh9A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 LEU A 371
VAL A 395
TYR A 355
GLY A 364
TYR A 402
 None
 1.31A 1fkoA-3ik2A:
undetectable		 1fkoA-3ik2A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		5 LEU A  53
VAL A  80
TYR A  93
GLY A  79
LEU A 100
 None
 1.41A 1fkoA-3ipwA:
undetectable		 1fkoA-3ipwA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		5 ASN A 190
VAL A  30
VAL A  35
GLY A  31
LEU A 165
 ADP  A 301 (-2.9A)
ADP  A 301 (-4.4A)
None
ADP  A 301 (-3.1A)
None
 1.38A 1fkoA-3kb1A:
undetectable		 1fkoA-3kb1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 LEU A 249
ASN A 188
GLY A 189
TRP A 209
LEU A 197
 None
 1.12A 1fkoA-3kehA:
0.7		 1fkoA-3kehA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A 116
VAL A 127
TYR A 120
GLY A 128
LEU A 101
 None
 1.46A 1fkoA-3kl4A:
1.7		 1fkoA-3kl4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 LEU X 514
VAL X 396
TYR X 399
GLY X 397
LEU X 515
 None
 1.37A 1fkoA-3lxuX:
2.8		 1fkoA-3lxuX:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A 448
VAL A 482
TYR A 415
TRP A 444
LEU A 527
 None
 1.39A 1fkoA-3n9vA:
undetectable		 1fkoA-3n9vA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.41A 1fkoA-3nksA:
2.2		 1fkoA-3nksA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU A   9
VAL A 277
VAL A  16
GLY A 278
TRP A  45
 None
 1.42A 1fkoA-3odtA:
undetectable		 1fkoA-3odtA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		5 LEU A 185
VAL A 131
TYR A 128
GLY A 191
LEU A  33
 DTD  A 248 ( 4.9A)
None
None
None
None
 1.30A 1fkoA-3oqvA:
undetectable		 1fkoA-3oqvA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 283
VAL A 298
VAL A 383
GLY A 368
LEU A 317
 None
 1.33A 1fkoA-3ov3A:
undetectable		 1fkoA-3ov3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sei CASKIN-1

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU A  21
ASN A  25
VAL A  49
GLY A  48
LEU A  19
 None
 1.12A 1fkoA-3seiA:
undetectable		 1fkoA-3seiA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		5 LEU A 155
VAL A 107
VAL A 102
TYR A 187
LEU A 151
 None
 1.00A 1fkoA-3tglA:
undetectable		 1fkoA-3tglA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl8 EFFECTOR PROTEIN
HOPAB2

(Pseudomonas
syringae group
genomosp. 3) 		PF16847
(AvrPtoB_bdg) 		5 LEU B 344
VAL B 290
VAL B 324
GLY B 288
LEU B 348
 None
 1.42A 1fkoA-3tl8B:
undetectable		 1fkoA-3tl8B:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		5 ASN A 455
VAL A 453
TYR A 764
GLY A 454
LEU A 529
 None
 1.02A 1fkoA-4areA:
undetectable		 1fkoA-4areA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		5 LEU A  80
VAL A 165
TYR A 113
GLY A 164
LEU A  78
 None
 1.32A 1fkoA-4bf7A:
undetectable		 1fkoA-4bf7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		5 LEU A 712
VAL A 736
TYR A 727
GLY A 643
LEU A 650
 None
 1.39A 1fkoA-4blaA:
undetectable		 1fkoA-4blaA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7w HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 LEU A 269
VAL A 241
TYR A 243
TYR A 234
LEU A 199
 None
 1.35A 1fkoA-4c7wA:
undetectable		 1fkoA-4c7wA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		5 LEU A 250
ASN A 257
VAL A 281
VAL A 224
LEU A 247
 None
 1.07A 1fkoA-4dzhA:
undetectable		 1fkoA-4dzhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		5 LEU A  31
ASN A 118
VAL A 116
GLY A 115
LEU A  29
 None
 1.27A 1fkoA-4e9kA:
undetectable		 1fkoA-4e9kA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eza RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2

(Homo sapiens) 		no annotation 5 LEU A  92
VAL A  46
VAL A   4
TYR A   6
LEU A  89
 None
 1.33A 1fkoA-4ezaA:
2.2		 1fkoA-4ezaA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0j PROBABLE HYDROLYTIC
ENZYME

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 LEU A 127
VAL A 133
GLY A 132
LEU A  43
TYR A  56
 None
 1.43A 1fkoA-4f0jA:
undetectable		 1fkoA-4f0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gio PUTATIVE LIPOPROTEIN

(Campylobacter
jejuni) 		PF07233
(DUF1425) 		5 LEU A 102
VAL A  29
VAL A  71
TYR A  69
LEU A  59
 None
 1.04A 1fkoA-4gioA:
undetectable		 1fkoA-4gioA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 LEU A1475
ASN A1473
TYR A1351
LEU A1455
TYR A1436
 None
 1.24A 1fkoA-4guaA:
undetectable		 1fkoA-4guaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides) 		no annotation 5 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.39A 1fkoA-4hehA:
undetectable		 1fkoA-4hehA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh1 APPA PROTEIN

(Rhodobacter
sphaeroides) 		PF04940
(BLUF) 		5 LEU A 394
VAL A 300
VAL A 273
GLY A 301
LEU A 390
 None
 1.40A 1fkoA-4hh1A:
3.4		 1fkoA-4hh1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmy ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf) 		5 LEU C 107
VAL C  23
VAL C  92
GLY C  24
LEU C 111
 None
 1.26A 1fkoA-4hmyC:
undetectable		 1fkoA-4hmyC:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjt ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A  19
ASN A  95
VAL A  60
GLY A  96
LEU A  54
 None
 1.24A 1fkoA-4jjtA:
undetectable		 1fkoA-4jjtA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kps HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 ASN A 150
VAL A  67
GLY A  68
TRP A 153
LEU A 252
 None
None
None
SIA  A 801 (-3.6A)
None
 1.22A 1fkoA-4kpsA:
undetectable		 1fkoA-4kpsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 415
ASN A 394
VAL A 367
GLY A 368
LEU A 376
 None
 1.45A 1fkoA-4mn8A:
undetectable		 1fkoA-4mn8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 CALCIUM-BINDING
PROTEIN 39

(Homo sapiens) 		PF08569
(Mo25) 		5 LEU A 218
VAL A 277
TYR A 214
GLY A 234
LEU A 258
 None
 1.41A 1fkoA-4o27A:
undetectable		 1fkoA-4o27A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		5 LEU A 328
VAL A 334
TYR A 260
GLY A 333
LEU A 303
 EDO  A 411 ( 4.5A)
None
None
None
None
 1.23A 1fkoA-4rgqA:
undetectable		 1fkoA-4rgqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhb LPS-ASSEMBLY PROTEIN
LPTD

(Escherichia
coli) 		PF04453
(OstA_C) 		5 LEU A 651
VAL A 700
VAL A 688
TYR A 780
GLY A 701
 None
 1.46A 1fkoA-4rhbA:
undetectable		 1fkoA-4rhbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9a TRIOSEPHOSPHATE
ISOMERASE

(Streptomyces
coelicolor) 		PF00121
(TIM) 		5 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.33A 1fkoA-4y9aA:
undetectable		 1fkoA-4y9aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 105
VAL A 112
GLY A  83
TRP A 145
LEU A  91
 None
 1.27A 1fkoA-4zoxA:
undetectable		 1fkoA-4zoxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		5 LEU A 115
VAL A 122
VAL A 161
GLY A 121
LEU A 112
 None
 1.46A 1fkoA-4zv1A:
undetectable		 1fkoA-4zv1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ams RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 105
VAL A 112
GLY A  83
TRP A 145
LEU A  91
 None
 1.21A 1fkoA-5amsA:
undetectable		 1fkoA-5amsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1530
VAL A1494
TYR A1552
TRP A1521
LEU A1560
 None
 1.12A 1fkoA-5e6pA:
2.1		 1fkoA-5e6pA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 LEU A 421
VAL A 438
VAL A 409
TYR A 417
GLY A 411
 None
 1.43A 1fkoA-5gk9A:
undetectable		 1fkoA-5gk9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		5 LEU A 204
VAL A 208
VAL A 251
GLY A 207
TYR A 233
 None
 1.37A 1fkoA-5h5jA:
undetectable		 1fkoA-5h5jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jem INTERFERON
REGULATORY FACTOR 3

(Homo sapiens) 		PF10401
(IRF-3) 		5 LEU A 245
VAL A 348
VAL A 261
TYR A 210
LEU A 228
 None
 1.33A 1fkoA-5jemA:
undetectable		 1fkoA-5jemA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jif HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 LEU A 262
VAL A 239
TYR A 241
TYR A 232
LEU A 202
 None
 1.43A 1fkoA-5jifA:
undetectable		 1fkoA-5jifA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqk PEPTIDASE, PUTATIVE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU A 648
ASN A 476
VAL A 478
TYR A 316
GLY A 318
 None
 1.35A 1fkoA-5jqkA:
undetectable		 1fkoA-5jqkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 435
VAL A 735
GLY A 734
LEU A 760
TYR A 431
 None
 1.05A 1fkoA-5kufA:
undetectable		 1fkoA-5kufA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 ASN A 219
VAL A 195
VAL A 294
GLY A 204
TYR A 272
 None
 1.21A 1fkoA-5lmzA:
undetectable		 1fkoA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 LEU A 273
ASN A 219
VAL A 195
GLY A 204
LEU A 225
 None
 1.18A 1fkoA-5lmzA:
undetectable		 1fkoA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmz FLUORINASE

(Streptomyces
sp. MA37) 		PF01887
(SAM_adeno_trans) 		5 LEU A 273
ASN A 219
VAL A 195
VAL A 294
GLY A 204
 None
 0.96A 1fkoA-5lmzA:
undetectable		 1fkoA-5lmzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n11 HEMAGGLUTININ-ESTERA
SE

(Betacoronavirus
1) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 LEU A 253
VAL A 230
TYR A 232
TYR A 223
LEU A 193
 None
 1.44A 1fkoA-5n11A:
undetectable		 1fkoA-5n11A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7e MB(BCR-DH_4)

(synthetic
construct) 		no annotation 5 LEU A  63
VAL A  67
TYR A  69
TYR A  93
GLY A  66
 None
 1.24A 1fkoA-5n7eA:
undetectable		 1fkoA-5n7eA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noa FAMILY 88 GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 LEU A 189
VAL A 232
VAL A 239
TYR A 253
GLY A 235
 None
 1.21A 1fkoA-5noaA:
undetectable		 1fkoA-5noaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		5 LEU A 104
VAL C  46
VAL C 101
TYR C 105
LEU A 105
 None
 1.45A 1fkoA-5osnA:
undetectable		 1fkoA-5osnA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 LEU A  99
VAL A 105
TYR A 180
GLY A 189
LEU A 233
TYR A 317
 None
 0.79A 1fkoA-5ovnA:
23.3		 1fkoA-5ovnA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 LEU A1620
VAL A1583
TYR A1642
TRP A1610
LEU A1650
 None
 1.17A 1fkoA-5v6tA:
undetectable		 1fkoA-5v6tA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn8 B12 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H  95
TYR H 100
TYR H 100
GLY H  96
TYR H  98
 None
 1.40A 1fkoA-5vn8H:
undetectable		 1fkoA-5vn8H:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 5 VAL A 474
VAL A 387
TYR A 468
GLY A 386
LEU A 441
 None
 1.42A 1fkoA-5ws4A:
5.1		 1fkoA-5ws4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE

(Chromobacterium
sp. USM2) 		PF07167
(PhaC_N) 		5 VAL A 292
VAL A 215
GLY A 293
LEU A 399
TYR A 264
 None
 1.29A 1fkoA-5xavA:
undetectable		 1fkoA-5xavA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z95 -

(-) 		no annotation 5 LEU A 232
VAL A 224
VAL A 238
GLY A 225
LEU A 202
 None
GOL  A 304 ( 4.3A)
None
None
None
 1.42A 1fkoA-5z95A:
undetectable		 1fkoA-5z95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bg8 IG DOMAIN PROTEIN,
GROUP 2 DOMAIN
PROTEIN

(Shewanella
frigidimarina) 		no annotation 5 LEU A 102
ASN A 107
VAL A 128
VAL A 153
TYR A 183
 None
 1.38A 1fkoA-6bg8A:
undetectable		 1fkoA-6bg8A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 5 LEU A 336
VAL A 287
TYR A 270
GLY A 288
LEU A 342
 None
 1.44A 1fkoA-6bs7A:
undetectable		 1fkoA-6bs7A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WDR5-BINDING
MONOBODY, MB(S4)

(Homo sapiens) 		no annotation 5 LEU M  62
VAL M  66
TYR M  68
TYR M  94
GLY M  65
 None
 1.29A 1fkoA-6bynM:
undetectable		 1fkoA-6bynM:
10.96