SIMILAR PATTERNS OF AMINO ACIDS FOR 1FKL_A_RAPA108_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN


(Propionibacterium
freudenreichii)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
5 GLU A 255
ILE A 240
TYR A 266
ILE A 200
ILE A 221
None
1.08A 1fklA-1e1cA:
undetectable
1fklA-1e1cA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 ASP A 352
VAL A 194
ILE A 193
ILE A 241
ILE A  24
None
1.08A 1fklA-1ee0A:
undetectable
1fklA-1ee0A:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
6 ASP A 142
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.16A 1fklA-1fd9A:
16.0
1fklA-1fd9A:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
8 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.63A 1fklA-1fd9A:
16.0
1fklA-1fd9A:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN


(Bos taurus)
PF00254
(FKBP_C)
9 TYR A  26
ASP A  37
ILE A  56
TRP A  59
TYR A  82
HIS A  87
ILE A  90
ILE A  91
PHE A  99
None
0.71A 1fklA-1fkkA:
22.2
1fklA-1fkkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN


(Bos taurus)
PF00254
(FKBP_C)
10 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  90
ILE A  91
PHE A  99
None
0.45A 1fklA-1fkkA:
22.2
1fklA-1fkkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN


(Bos taurus)
PF00254
(FKBP_C)
9 TYR A  26
GLU A  54
ILE A  56
TRP A  59
TYR A  82
HIS A  87
ILE A  90
ILE A  91
PHE A  99
None
0.77A 1fklA-1fkkA:
22.2
1fklA-1fkkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN


(Bos taurus)
PF00254
(FKBP_C)
10 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  90
ILE A  91
PHE A  99
None
0.50A 1fklA-1fkkA:
22.2
1fklA-1fkkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays)
PF00232
(Glyco_hydro_1)
6 TYR A 163
PHE A 151
VAL A 140
TRP A  96
HIS A 137
PHE A 166
None
1.38A 1fklA-1hxjA:
undetectable
1fklA-1hxjA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR


(Trypanosoma
cruzi)
PF00254
(FKBP_C)
7 TYR A  92
ASP A 103
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
None
0.64A 1fklA-1jvwA:
15.3
1fklA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR


(Trypanosoma
cruzi)
PF00254
(FKBP_C)
8 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
None
0.44A 1fklA-1jvwA:
15.3
1fklA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR


(Trypanosoma
cruzi)
PF00254
(FKBP_C)
7 TYR A  92
PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
None
0.90A 1fklA-1jvwA:
15.3
1fklA-1jvwA:
42.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51


(Saimiri
boliviensis)
PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8)
6 TYR A  57
PHE A  77
ILE A  87
TRP A  90
ILE A 122
PHE A 130
None
0.99A 1fklA-1kt1A:
15.5
1fklA-1kt1A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51


(Saimiri
boliviensis)
PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8)
6 TYR A  57
PHE A  77
ILE A  87
TRP A  90
TYR A 113
PHE A 130
None
0.82A 1fklA-1kt1A:
15.5
1fklA-1kt1A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51


(Saimiri
boliviensis)
PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8)
5 TYR A  57
PHE A  77
VAL A  86
TRP A  90
ILE A 122
None
0.87A 1fklA-1kt1A:
15.5
1fklA-1kt1A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51


(Saimiri
boliviensis)
PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8)
6 TYR A  57
PHE A  77
VAL A  86
TRP A  90
TYR A 113
PHE A 130
None
0.71A 1fklA-1kt1A:
15.5
1fklA-1kt1A:
24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens)
PF00254
(FKBP_C)
10 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
0.72A 1fklA-1n1aA:
18.2
1fklA-1n1aA:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens)
PF00254
(FKBP_C)
6 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A 122
None
1.00A 1fklA-1n1aA:
18.2
1fklA-1n1aA:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 208
PHE A 216
RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
None
0.31A 1fklA-1pbkA:
19.6
1fklA-1pbkA:
44.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA


(Escherichia
coli)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
8 TYR A 146
ASP A 157
VAL A 173
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
None
0.56A 1fklA-1q6hA:
15.9
1fklA-1q6hA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY


(Caenorhabditis
elegans)
PF00254
(FKBP_C)
8 TYR A  40
ASP A  51
PHE A  60
VAL A  69
ILE A  70
TRP A  73
ILE A 105
PHE A 113
None
0.62A 1fklA-1r9hA:
20.0
1fklA-1r9hA:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY


(Caenorhabditis
elegans)
PF00254
(FKBP_C)
6 TYR A  40
ASP A  51
PHE A  60
VAL A  69
TRP A  73
ILE A 105
None
1.26A 1fklA-1r9hA:
20.0
1fklA-1r9hA:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY


(Caenorhabditis
elegans)
PF00254
(FKBP_C)
8 TYR A  40
PHE A  60
VAL A  69
ILE A  70
TRP A  73
TYR A  96
ILE A 105
PHE A 113
None
0.39A 1fklA-1r9hA:
20.0
1fklA-1r9hA:
45.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1


(Saccharomyces
cerevisiae)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
5 PHE A 349
VAL A 466
ILE A 465
TYR A 454
ILE A 458
None
1.11A 1fklA-1ry2A:
undetectable
1fklA-1ry2A:
9.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3


(Arabidopsis
thaliana)
PF00254
(FKBP_C)
9 TYR A  37
ASP A  48
GLU A  65
VAL A  66
ILE A  67
TRP A  70
TYR A  99
ILE A 113
PHE A 121
None
0.53A 1fklA-1u79A:
17.6
1fklA-1u79A:
36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3


(Arabidopsis
thaliana)
PF00254
(FKBP_C)
5 TYR A  37
ASP A  48
GLU A  65
VAL A  66
ILE A 113
None
1.10A 1fklA-1u79A:
17.6
1fklA-1u79A:
36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN


(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
9 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
None
0.36A 1fklA-1yatA:
20.6
1fklA-1yatA:
57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN


(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
5 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  91
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
None
1.10A 1fklA-1yatA:
20.6
1fklA-1yatA:
57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Aedes aegypti)
PF00254
(FKBP_C)
6 TYR A  27
GLU A  55
VAL A  56
ILE A  57
TRP A  60
ILE A  92
None
1.02A 1fklA-2lpvA:
17.8
1fklA-2lpvA:
72.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Aedes aegypti)
PF00254
(FKBP_C)
6 TYR A  27
PHE A  47
GLU A  55
ILE A  57
TRP A  60
ILE A  92
None
1.00A 1fklA-2lpvA:
17.8
1fklA-2lpvA:
72.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
None
0.88A 1fklA-2pbcA:
15.8
1fklA-2pbcA:
46.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2


(Homo sapiens)
PF00254
(FKBP_C)
5 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A 121
PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
None
0.97A 1fklA-2pbcA:
15.8
1fklA-2pbcA:
46.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
5 ASP A  66
VAL A  82
ILE A  83
TRP A  86
PHE A 126
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 ( 4.7A)
0.86A 1fklA-2vcdA:
13.6
1fklA-2vcdA:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
5 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
0.84A 1fklA-2vcdA:
13.6
1fklA-2vcdA:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
5 TYR A  55
VAL A  82
ILE A  83
TRP A  86
TYR A 109
RAP  A 138 (-2.6A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
0.72A 1fklA-2vcdA:
13.6
1fklA-2vcdA:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE


(Plasmodium
falciparum)
PF00254
(FKBP_C)
10 TYR A  44
ASP A  56
PHE A  65
GLU A  73
VAL A  74
ILE A  75
TRP A  78
TYR A 101
ILE A 110
PHE A 118
FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.1A)
None
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
FK5  A 501 (-4.8A)
0.44A 1fklA-2vn1A:
19.8
1fklA-2vn1A:
41.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE


(Plasmodium
falciparum)
PF00254
(FKBP_C)
6 TYR A  44
ASP A  56
PHE A  65
GLU A  73
VAL A  74
ILE A 110
FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.1A)
None
FK5  A 501 (-3.5A)
None
1.23A 1fklA-2vn1A:
19.8
1fklA-2vn1A:
41.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei)
PF00254
(FKBP_C)
8 TYR A  33
ASP A  44
PHE A  53
VAL A  62
TRP A  66
TYR A  89
ILE A  98
PHE A 106
None
0.71A 1fklA-2y78A:
18.0
1fklA-2y78A:
52.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei)
PF00254
(FKBP_C)
8 TYR A  33
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
None
0.46A 1fklA-2y78A:
18.0
1fklA-2y78A:
52.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE


(Pseudomonas sp.
ATCC 19121)
PF00155
(Aminotran_1_2)
5 ASP A 286
PHE A 204
ILE A 210
ILE A 181
PHE A 250
PLP  A 900 (-3.2A)
PLP  A 900 (-4.2A)
None
None
None
1.07A 1fklA-2zy2A:
undetectable
1fklA-2zy2A:
11.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
None
0.78A 1fklA-3o5dA:
18.9
1fklA-3o5dA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
0.66A 1fklA-3o5dA:
18.9
1fklA-3o5dA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
ILE A 122
PHE A 130
None
0.80A 1fklA-3o5eA:
18.8
1fklA-3o5eA:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
None
1.08A 1fklA-3o5eA:
18.8
1fklA-3o5eA:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
None
0.82A 1fklA-3o5eA:
18.8
1fklA-3o5eA:
40.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE


(Plasmodium
vivax)
PF00254
(FKBP_C)
6 TYR A  43
ASP A  55
PHE A  64
GLU A  72
VAL A  73
ILE A 109
None
1.02A 1fklA-3pa7A:
19.3
1fklA-3pa7A:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE


(Plasmodium
vivax)
PF00254
(FKBP_C)
8 TYR A  43
ASP A  55
PHE A  64
GLU A  72
VAL A  73
TRP A  77
ILE A 109
PHE A 117
None
0.68A 1fklA-3pa7A:
19.3
1fklA-3pa7A:
40.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE


(Plasmodium
vivax)
PF00254
(FKBP_C)
9 TYR A  43
PHE A  64
GLU A  72
VAL A  73
ILE A  74
TRP A  77
TYR A 100
ILE A 109
PHE A 117
None
0.51A 1fklA-3pa7A:
19.3
1fklA-3pa7A:
40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
None
1.02A 1fklA-3sqwA:
undetectable
1fklA-3sqwA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus)
PF01670
(Glyco_hydro_12)
5 ASP A 111
GLU A 302
VAL A 107
ILE A 113
ILE A  86
None
1.05A 1fklA-3wq1A:
undetectable
1fklA-3wq1A:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
5 GLU A 340
VAL A 341
TRP A 345
ILE A 376
PHE A 384
None
1.11A 1fklA-4bf8A:
16.6
1fklA-4bf8A:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
7 TYR A 313
ASP A 324
PHE A 332
VAL A 341
ILE A 342
TRP A 345
PHE A 384
None
0.83A 1fklA-4bf8A:
16.6
1fklA-4bf8A:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
8 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
None
0.79A 1fklA-4bf8A:
16.6
1fklA-4bf8A:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
8 TYR A 313
GLU A 340
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
None
1.09A 1fklA-4bf8A:
16.6
1fklA-4bf8A:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
7 TYR A 313
PHE A 332
GLU A 340
VAL A 341
ILE A 342
TRP A 345
PHE A 384
None
1.13A 1fklA-4bf8A:
16.6
1fklA-4bf8A:
39.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 ASP A 461
GLU A 328
ILE A 248
ILE A 263
PHE A 244
MN  A 802 ( 4.1A)
None
None
None
None
0.95A 1fklA-4db1A:
undetectable
1fklA-4db1A:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00271
(Helicase_C)
5 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
None
1.06A 1fklA-4db4A:
undetectable
1fklA-4db4A:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14


(Homo sapiens)
PF00254
(FKBP_C)
5 TYR A  52
GLU A  83
TYR A 111
ILE A 119
PHE A 127
None
0.81A 1fklA-4dipA:
17.3
1fklA-4dipA:
35.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14


(Homo sapiens)
PF00254
(FKBP_C)
5 TYR A  52
TRP A  88
TYR A 111
ILE A 119
PHE A 127
None
0.59A 1fklA-4dipA:
17.3
1fklA-4dipA:
35.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei)
PF00254
(FKBP_C)
9 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
FK5  A 201 (-4.8A)
0.34A 1fklA-4dz3A:
18.9
1fklA-4dz3A:
54.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx0 PROBABLE
TRANSCRIPTIONAL
REPRESSOR PROTEIN


(Mycobacterium
tuberculosis)
PF12802
(MarR_2)
5 GLU A  69
VAL A  68
ILE A  66
ILE A  99
ILE A  46
None
1.06A 1fklA-4fx0A:
undetectable
1fklA-4fx0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3


(Homo sapiens)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
5 ASP B 851
GLU B 717
VAL B 718
ILE B 719
TYR B 847
None
0.90A 1fklA-4gnkB:
undetectable
1fklA-4gnkB:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5


(Saccharomyces
cerevisiae)
PF09084
(NMT1)
5 PHE A 209
GLU A 215
VAL A 217
ILE A  39
ILE A  21
None
1.04A 1fklA-4h65A:
undetectable
1fklA-4h65A:
16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  26
ASP A  37
PHE A  46
GLU A  54
TYR A  82
HIS A  87
ILE A  91
PHE A  99
None
0.83A 1fklA-4iqcA:
21.6
1fklA-4iqcA:
85.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TYR A  82
HIS A  87
ILE A  91
PHE A  99
None
0.75A 1fklA-4iqcA:
21.6
1fklA-4iqcA:
85.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus)
no annotation 5 TYR A 146
GLU A 121
VAL A 120
ILE A 155
ILE A 204
None
1.08A 1fklA-4ix1A:
undetectable
1fklA-4ix1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
PHE A 130
None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
0.56A 1fklA-4lawA:
19.6
1fklA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4


(Homo sapiens)
PF00254
(FKBP_C)
6 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A 122
None
None
None
None
DMS  A 304 (-3.5A)
None
0.86A 1fklA-4lawA:
19.6
1fklA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
0.57A 1fklA-4lawA:
19.6
1fklA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 TYR A1199
GLU A1122
VAL A1206
ILE A1205
ILE A1294
None
1.09A 1fklA-4ldeA:
undetectable
1fklA-4ldeA:
12.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14


(Homo sapiens)
PF00254
(FKBP_C)
PF13499
(EF-hand_7)
5 TYR A  33
GLU A  64
TYR A  92
ILE A 100
PHE A 108
None
0.75A 1fklA-4mspA:
18.0
1fklA-4mspA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14


(Homo sapiens)
PF00254
(FKBP_C)
PF13499
(EF-hand_7)
5 TYR A  33
TRP A  69
TYR A  92
ILE A 100
PHE A 108
None
0.52A 1fklA-4mspA:
18.0
1fklA-4mspA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
None
FK5  A 201 (-4.9A)
0.36A 1fklA-4nnrA:
16.5
1fklA-4nnrA:
39.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens)
PF00644
(PARP)
5 TYR A1203
GLU A1291
ILE A1212
ILE A1189
ILE A1192
2XS  A1402 (-3.1A)
None
2XS  A1402 ( 4.3A)
None
2XS  A1402 ( 4.7A)
0.94A 1fklA-4oa7A:
undetectable
1fklA-4oa7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD


(Thermus
thermophilus)
PF00254
(FKBP_C)
5 TYR A  13
ASP A  23
ILE A  37
TYR A  63
PHE A 128
None
0.57A 1fklA-4odmA:
11.9
1fklA-4odmA:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA


(Homo sapiens;
Thermus
thermophilus)
PF00254
(FKBP_C)
8 TYR A  13
ASP A  23
ILE A  37
TYR A  63
HIS A  68
ILE A  71
ILE A  72
PHE A  80
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.1A)
None
FK5  A 201 ( 4.8A)
0.67A 1fklA-4odrA:
13.6
1fklA-4odrA:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opw UNCHARACTERIZED
PROTEIN


(Parabacteroides
merdae)
PF10988
(DUF2807)
5 ASP A  68
VAL A  49
ILE A  50
ILE A  65
PHE A  88
None
None
None
None
EDO  A 301 (-4.3A)
1.00A 1fklA-4opwA:
undetectable
1fklA-4opwA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
PHE A 130
None
0.69A 1fklA-4r0xA:
19.1
1fklA-4r0xA:
45.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
0.75A 1fklA-4r0xA:
19.1
1fklA-4r0xA:
45.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN


(Saccharophagus
degradans)
PF15979
(Glyco_hydro_115)
5 ASP A 944
PHE A 845
ILE A 840
TYR A 459
ILE A 883
None
1.07A 1fklA-4zmhA:
undetectable
1fklA-4zmhA:
7.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Coccidioides
immitis)
PF00254
(FKBP_C)
9 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
ILE C 109
PHE C 117
FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
FK5  C 201 (-4.7A)
0.32A 1fklA-5b8iC:
20.1
1fklA-5b8iC:
41.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A


(Escherichia
coli;
Homo sapiens)
PF00254
(FKBP_C)
10 TYR A  26
ASP A  37
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
HIS A 137
PHE A 146
None
0.89A 1fklA-5i7pA:
20.3
1fklA-5i7pA:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A


(Escherichia
coli;
Homo sapiens)
PF00254
(FKBP_C)
10 TYR A  26
ASP A  37
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
HIS A 138
PHE A 147
None
0.97A 1fklA-5i7qA:
20.6
1fklA-5i7qA:
64.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1


(Candida
albicans)
PF00254
(FKBP_C)
9 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 105
ILE A 102
None
1.42A 1fklA-5i98A:
19.2
1fklA-5i98A:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1


(Candida
albicans)
PF00254
(FKBP_C)
10 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 105
ILE A 106
PHE A 114
None
0.52A 1fklA-5i98A:
19.2
1fklA-5i98A:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1


(Candida
albicans)
PF00254
(FKBP_C)
8 TYR A  30
ASP A  41
PHE A  50
VAL A  59
TRP A  63
ILE A 102
ILE A 106
PHE A 114
None
1.15A 1fklA-5i98A:
19.2
1fklA-5i98A:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A


(Aspergillus
fumigatus)
PF00254
(FKBP_C)
9 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  57
TRP A  60
TYR A  83
ILE A  92
PHE A 100
None
0.65A 1fklA-5j6eA:
20.8
1fklA-5j6eA:
58.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A


(Aspergillus
fumigatus)
PF00254
(FKBP_C)
5 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  92
None
1.05A 1fklA-5j6eA:
20.8
1fklA-5j6eA:
58.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes)
PF04203
(Sortase)
5 ASP A 125
VAL A  75
ILE A  89
TYR A 161
ILE A 221
None
1.02A 1fklA-5jcvA:
undetectable
1fklA-5jcvA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15


(Thermobia
domestica)
no annotation 5 ASP A  84
VAL A  72
ILE A 190
TYR A  75
ILE A  81
None
1.08A 1fklA-5mszA:
undetectable
1fklA-5mszA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3


(Homo sapiens)
PF02469
(Fasciclin)
5 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
None
1.11A 1fklA-5nv6A:
undetectable
1fklA-5nv6A:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
no annotation 5 GLU C 540
VAL C 542
ILE C 543
ILE C 497
ILE C 519
None
0.95A 1fklA-5oyjC:
undetectable
1fklA-5oyjC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae)
no annotation 9 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
8ZV  A 201 ( 4.8A)
8ZV  A 201 (-4.6A)
0.37A 1fklA-5v8tA:
18.9
1fklA-5v8tA:
24.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF00254
(FKBP_C)
8 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
0.70A 1fklA-5xb0A:
15.5
1fklA-5xb0A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF00254
(FKBP_C)
7 TYR A 147
PHE A 166
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
TLA  A 301 ( 4.4A)
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
1.01A 1fklA-5xb0A:
15.5
1fklA-5xb0A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF00254
(FKBP_C)
5 TYR A 147
VAL A 171
TRP A 175
ILE A 207
PHE A 215
TLA  A 301 ( 4.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
1.06A 1fklA-5xb0A:
15.5
1fklA-5xb0A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE


(Naegleria
fowleri)
no annotation 10 TYR A  38
ASP A  49
PHE A  58
GLU A  66
VAL A  67
ILE A  68
TRP A  71
TYR A  94
ILE A 103
PHE A 111
None
0.74A 1fklA-6b4pA:
19.5
1fklA-6b4pA:
42.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE


(Naegleria
fowleri)
no annotation 6 TYR A  38
ASP A  49
PHE A  58
GLU A  66
VAL A  67
ILE A 103
None
1.04A 1fklA-6b4pA:
19.5
1fklA-6b4pA:
42.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE


(Naegleria
fowleri)
no annotation 6 TYR A  38
PHE A  58
TRP A  71
ILE A  99
ILE A 103
PHE A 111
None
1.41A 1fklA-6b4pA:
19.5
1fklA-6b4pA:
42.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-)
no annotation 5 ASP A 461
GLU A 328
ILE A 248
ILE A 263
PHE A 244
None
1.10A 1fklA-6fsaA:
undetectable
1fklA-6fsaA:
undetectable