SIMILAR PATTERNS OF AMINO ACIDS FOR 1FKB_A_RAPA108_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
PHE A 202
 None
 1.17A 1fkbA-1fd9A:
16.2		 1fkbA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		7 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
 None
 0.59A 1fkbA-1fd9A:
16.2		 1fkbA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
GLU A  54
TRP A  59
TYR A  82
HIS A  87
ILE A  90
PHE A  99
 None
 0.89A 1fkbA-1fkkA:
22.4		 1fkbA-1fkkA:
97.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		11 TYR A  26
ASP A  37
PHE A  46
GLN A  53
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  90
PHE A  99
 None
 0.69A 1fkbA-1fkkA:
22.4		 1fkbA-1fkkA:
97.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		6 TYR A  26
PHE A  46
GLU A  54
VAL A  55
TRP A  59
ILE A  91
 None
 1.19A 1fkbA-1fkkA:
22.4		 1fkbA-1fkkA:
97.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		6 TYR A 163
PHE A 151
VAL A 140
TRP A  96
HIS A 137
PHE A 166
 None
 1.37A 1fkbA-1hxjA:
undetectable		 1fkbA-1hxjA:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 PHE A 114
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 1.02A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
ASP A 103
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.64A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
GLU A 118
VAL A 119
ILE A 120
TRP A 123
TYR A 146
PHE A 163
 None
 0.46A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 TYR A  92
GLU A 118
VAL A 119
TRP A 123
ILE A 155
 None
 1.17A 1fkbA-1jvwA:
15.5		 1fkbA-1jvwA:
42.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
 None
 1.06A 1fkbA-1kt1A:
15.5		 1fkbA-1kt1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.80A 1fkbA-1kt1A:
15.5		 1fkbA-1kt1A:
23.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.74A 1fkbA-1n1aA:
18.2		 1fkbA-1n1aA:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
TRP A  90
ILE A 122
 None
 1.14A 1fkbA-1n1aA:
18.2		 1fkbA-1n1aA:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
None
 0.29A 1fkbA-1pbkA:
19.6		 1fkbA-1pbkA:
43.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		7 TYR A 146
ASP A 157
VAL A 173
ILE A 174
TRP A 177
TYR A 200
PHE A 216
 None
 0.54A 1fkbA-1q6hA:
16.0		 1fkbA-1q6hA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		8 TYR A  40
ASP A  51
PHE A  60
VAL A  69
ILE A  70
TRP A  73
TYR A  96
PHE A 113
 None
 0.61A 1fkbA-1r9hA:
20.1		 1fkbA-1r9hA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		6 TYR A  40
ASP A  51
PHE A  60
VAL A  69
TRP A  73
ILE A 105
 None
 1.25A 1fkbA-1r9hA:
20.1		 1fkbA-1r9hA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		8 TYR A  37
ASP A  48
GLU A  65
VAL A  66
ILE A  67
TRP A  70
TYR A  99
PHE A 121
 None
 0.50A 1fkbA-1u79A:
17.6		 1fkbA-1u79A:
36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		6 TYR A  37
ASP A  48
GLU A  65
VAL A  66
TRP A  70
ILE A 113
 None
 1.18A 1fkbA-1u79A:
17.6		 1fkbA-1u79A:
36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 3.6A)
FK5  A 108 ( 4.7A)
None
 0.34A 1fkbA-1yatA:
20.8		 1fkbA-1yatA:
57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 TYR A  26
PHE A  46
VAL A  55
TRP A  59
ILE A  91
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.6A)
None
 1.00A 1fkbA-1yatA:
20.8		 1fkbA-1yatA:
57.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		5 ASP A  35
GLN A  23
GLU A  26
ILE A 280
ILE A  45
 None
 1.20A 1fkbA-2ftpA:
undetectable		 1fkbA-2ftpA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv8 AP-2 COMPLEX SUBUNIT
BETA-1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2)
PF09066
(B2-adapt-app_C) 		5 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 1.00A 1fkbA-2iv8A:
undetectable		 1fkbA-2iv8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j23 THIOREDOXIN

(Malassezia
sympodialis) 		PF00085
(Thioredoxin) 		5 PHE A  80
GLN A  67
GLU A  68
VAL A  69
ILE A  71
 None
 1.17A 1fkbA-2j23A:
undetectable		 1fkbA-2j23A:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
GLU A  55
VAL A  56
ILE A  57
TRP A  60
 None
 0.87A 1fkbA-2lpvA:
17.9		 1fkbA-2lpvA:
71.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Aedes aegypti) 		PF00254
(FKBP_C) 		5 TYR A  27
PHE A  47
GLU A  55
ILE A  57
TRP A  60
 None
 0.92A 1fkbA-2lpvA:
17.9		 1fkbA-2lpvA:
71.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
 0.77A 1fkbA-2pbcA:
15.8		 1fkbA-2pbcA:
47.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A 121
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
None
 0.93A 1fkbA-2pbcA:
15.8		 1fkbA-2pbcA:
47.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 ASP A  66
VAL A  82
ILE A  83
TRP A  86
PHE A 126
 RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 ( 4.7A)
 0.87A 1fkbA-2vcdA:
13.6		 1fkbA-2vcdA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
 RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
 0.84A 1fkbA-2vcdA:
13.6		 1fkbA-2vcdA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 TYR A  55
VAL A  82
ILE A  83
TRP A  86
TYR A 109
 RAP  A 138 (-2.6A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
 0.70A 1fkbA-2vcdA:
13.6		 1fkbA-2vcdA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		9 TYR A  44
ASP A  56
PHE A  65
GLU A  73
VAL A  74
ILE A  75
TRP A  78
TYR A 101
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.1A)
None
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
FK5  A 501 (-4.8A)
 0.44A 1fkbA-2vn1A:
19.8		 1fkbA-2vn1A:
40.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
PHE A  65
GLU A  73
VAL A  74
ILE A 110
 FK5  A 501 (-4.1A)
FK5  A 501 (-4.1A)
None
FK5  A 501 (-3.5A)
None
 1.04A 1fkbA-2vn1A:
19.8		 1fkbA-2vn1A:
40.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 0.98A 1fkbA-2vxpA:
undetectable		 1fkbA-2vxpA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  98
 None
 1.14A 1fkbA-2y78A:
18.2		 1fkbA-2y78A:
47.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		7 TYR A  33
ASP A  44
PHE A  53
VAL A  62
TRP A  66
TYR A  89
PHE A 106
 None
 0.67A 1fkbA-2y78A:
18.2		 1fkbA-2y78A:
47.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		7 TYR A  33
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
PHE A 106
 None
 0.41A 1fkbA-2y78A:
18.2		 1fkbA-2y78A:
47.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		5 ASP A  95
ILE A 129
HIS A  98
ILE A   4
PHE A  89
 None
 1.15A 1fkbA-3cq9A:
undetectable		 1fkbA-3cq9A:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.80A 1fkbA-3o5dA:
18.9		 1fkbA-3o5dA:
32.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
PHE A  77
VAL A  86
TRP A  90
ILE A 122
 None
 1.20A 1fkbA-3o5dA:
18.9		 1fkbA-3o5dA:
32.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
 0.81A 1fkbA-3o5eA:
18.9		 1fkbA-3o5eA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
 1.09A 1fkbA-3o5eA:
18.9		 1fkbA-3o5eA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.82A 1fkbA-3o5eA:
18.9		 1fkbA-3o5eA:
39.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohp HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF00156
(Pribosyltran) 		5 GLN A  12
GLU A  13
VAL A  14
ILE A  18
PHE A  47
 None
 1.22A 1fkbA-3ohpA:
undetectable		 1fkbA-3ohpA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orj SUGAR-BINDING
PROTEIN

(Bacteroides
ovatus) 		no annotation 5 PHE A 364
GLN A 317
VAL A 372
TYR A 350
ILE A 421
 None
 1.20A 1fkbA-3orjA:
undetectable		 1fkbA-3orjA:
12.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		7 TYR A  43
ASP A  55
PHE A  64
GLU A  72
VAL A  73
TRP A  77
ILE A 109
 None
 1.19A 1fkbA-3pa7A:
19.4		 1fkbA-3pa7A:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		7 TYR A  43
ASP A  55
PHE A  64
GLU A  72
VAL A  73
TRP A  77
PHE A 117
 None
 0.55A 1fkbA-3pa7A:
19.4		 1fkbA-3pa7A:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		8 TYR A  43
PHE A  64
GLU A  72
VAL A  73
ILE A  74
TRP A  77
TYR A 100
PHE A 117
 None
 0.45A 1fkbA-3pa7A:
19.4		 1fkbA-3pa7A:
39.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uto TWITCHIN

(Caenorhabditis
elegans) 		PF00041
(fn3)
PF00069
(Pkinase)
PF07679
(I-set) 		5 ASP A 297
PHE A 167
GLN A 464
GLU A 465
ILE A 468
 None
 1.17A 1fkbA-3utoA:
undetectable		 1fkbA-3utoA:
10.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		5 GLU A 340
VAL A 341
TRP A 345
ILE A 376
PHE A 384
 None
 1.08A 1fkbA-4bf8A:
16.5		 1fkbA-4bf8A:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 TYR A 313
ASP A 324
PHE A 332
ILE A 342
TRP A 345
PHE A 384
 None
 0.87A 1fkbA-4bf8A:
16.5		 1fkbA-4bf8A:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
PHE A 384
 None
 0.70A 1fkbA-4bf8A:
16.5		 1fkbA-4bf8A:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
GLU A 340
VAL A 341
ILE A 342
TRP A 345
TYR A 368
PHE A 384
 None
 1.09A 1fkbA-4bf8A:
16.5		 1fkbA-4bf8A:
38.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		6 TYR A 313
PHE A 332
GLU A 340
ILE A 342
TRP A 345
PHE A 384
 None
 1.11A 1fkbA-4bf8A:
16.5		 1fkbA-4bf8A:
38.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxe ACYL-CARRIER-PROTEIN
SYNTHASE

(Staphylococcus
aureus) 		PF01648
(ACPS) 		5 PHE A  38
GLU A  44
ILE A  15
HIS A 103
ILE A 101
 None
None
None
MLI  A 201 (-4.4A)
MLI  A 201 ( 4.1A)
 1.21A 1fkbA-4dxeA:
undetectable		 1fkbA-4dxeA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		8 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
FK5  A 201 (-4.8A)
 0.30A 1fkbA-4dz3A:
19.0		 1fkbA-4dz3A:
53.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASP A 154
GLN A 242
VAL A 231
ILE A 257
ILE A 156
 None
 1.12A 1fkbA-4f7kA:
undetectable		 1fkbA-4f7kA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqg TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		5 TYR A 116
ASP A  75
GLU A  88
VAL A  89
ILE A  93
 None
 1.08A 1fkbA-4fqgA:
undetectable		 1fkbA-4fqgA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 ASP B 851
GLU B 717
VAL B 718
ILE B 719
TYR B 847
 None
 0.87A 1fkbA-4gnkB:
undetectable		 1fkbA-4gnkB:
7.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
GLU A  54
ILE A  56
TYR A  82
HIS A  87
PHE A  99
 None
 0.88A 1fkbA-4iqcA:
21.9		 1fkbA-4iqcA:
83.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
PHE A  46
GLN A  53
GLU A  54
VAL A  55
ILE A  56
TYR A  82
HIS A  87
PHE A  99
 None
 0.95A 1fkbA-4iqcA:
21.9		 1fkbA-4iqcA:
83.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  91
PHE A  99
 None
 1.39A 1fkbA-4iqcA:
21.9		 1fkbA-4iqcA:
83.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 5 TYR A 146
GLU A 121
VAL A 120
ILE A 155
ILE A 204
 None
 1.11A 1fkbA-4ix1A:
undetectable		 1fkbA-4ix1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0x BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		5 GLN A 176
GLU A 177
ILE A 150
ILE A 138
PHE A 191
 None
 1.14A 1fkbA-4k0xA:
undetectable		 1fkbA-4k0xA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
PHE A 130
 None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
DMS  A 304 (-4.3A)
 0.55A 1fkbA-4lawA:
19.6		 1fkbA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
GLU A  85
VAL A  86
ILE A 122
 None
None
None
None
DMS  A 304 (-3.5A)
None
 0.85A 1fkbA-4lawA:
19.6		 1fkbA-4lawA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  57
PHE A  77
GLU A  85
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
 0.55A 1fkbA-4lawA:
19.6		 1fkbA-4lawA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
FK5  A 201 (-4.9A)
 0.31A 1fkbA-4nnrA:
16.5		 1fkbA-4nnrA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
PHE A  76
VAL A  85
TRP A  89
ILE A 121
 FK5  A 201 (-4.1A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.5A)
None
 1.06A 1fkbA-4nnrA:
16.5		 1fkbA-4nnrA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
HIS A 119
PHE A 128
 None
 0.92A 1fkbA-4odmA:
12.0		 1fkbA-4odmA:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
HIS A  68
ILE A  71
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.1A)
 0.66A 1fkbA-4odrA:
13.7		 1fkbA-4odrA:
33.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
ILE A  71
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
FK5  A 201 ( 4.1A)
FK5  A 201 ( 4.8A)
 0.50A 1fkbA-4odrA:
13.7		 1fkbA-4odrA:
33.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
 0.94A 1fkbA-4r0xA:
19.3		 1fkbA-4r0xA:
45.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
VAL A  86
TRP A  90
PHE A 130
 None
 0.68A 1fkbA-4r0xA:
19.3		 1fkbA-4r0xA:
45.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
 None
 0.68A 1fkbA-4r0xA:
19.3		 1fkbA-4r0xA:
45.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkj CRISPR-ASSOCIATED
PROTEIN CAS1

(Streptococcus
pyogenes) 		PF01867
(Cas_Cas1) 		5 TYR A 181
GLN A 236
VAL A 230
ILE A 229
ILE A 289
 None
 1.01A 1fkbA-4zkjA:
undetectable		 1fkbA-4zkjA:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		8 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.30A 1fkbA-5b8iC:
20.3		 1fkbA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		5 TYR C  36
PHE C  64
VAL C  73
TRP C  77
ILE C 109
 FK5  C 201 (-4.1A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.4A)
None
 1.04A 1fkbA-5b8iC:
20.3		 1fkbA-5b8iC:
43.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		8 ASP A  37
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
HIS A 137
PHE A 146
 None
 0.92A 1fkbA-5i7pA:
20.6		 1fkbA-5i7pA:
62.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 146
 None
 0.53A 1fkbA-5i7pA:
20.6		 1fkbA-5i7pA:
62.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		11 TYR A  26
ASP A  37
PHE A  46
GLN A  53
GLU A  54
VAL A  55
ILE A  56
TRP A  59
TYR A  82
HIS A 138
PHE A 147
 None
 0.92A 1fkbA-5i7qA:
20.8		 1fkbA-5i7qA:
65.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		9 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 105
PHE A 114
 None
 0.55A 1fkbA-5i98A:
19.3		 1fkbA-5i98A:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		6 TYR A  30
PHE A  50
VAL A  59
TRP A  63
ILE A 102
PHE A 114
 None
 0.95A 1fkbA-5i98A:
19.3		 1fkbA-5i98A:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		5 TYR A  30
PHE A  50
VAL A  59
TRP A  63
ILE A 106
 None
 1.13A 1fkbA-5i98A:
19.3		 1fkbA-5i98A:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		8 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  57
TRP A  60
TYR A  83
PHE A 100
 None
 0.62A 1fkbA-5j6eA:
20.9		 1fkbA-5j6eA:
57.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		5 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  92
 None
 1.05A 1fkbA-5j6eA:
20.9		 1fkbA-5j6eA:
57.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 GLN A 183
ILE A  65
HIS A  63
ILE A  44
PHE A 172
 None
 1.21A 1fkbA-5kkgA:
undetectable		 1fkbA-5kkgA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n81 TYROCIDINE SYNTHASE
1

(Brevibacillus
parabrevis) 		no annotation 5 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.12A 1fkbA-5n81A:
undetectable		 1fkbA-5n81A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 PHE A 515
GLU A 615
VAL A 627
ILE A 628
ILE A 573
 None
 1.05A 1fkbA-5nv6A:
undetectable		 1fkbA-5nv6A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux9 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Aliivibrio
fischeri) 		PF00132
(Hexapep) 		5 TYR A 158
ASP A 124
GLN A 210
GLU A 206
ILE A 183
 None
 1.20A 1fkbA-5ux9A:
undetectable		 1fkbA-5ux9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 8 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
8ZV  A 201 (-4.6A)
 0.31A 1fkbA-5v8tA:
19.0		 1fkbA-5v8tA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 135
ASP A 195
GLN A 129
GLU A 126
ILE A 222
 None
None
AJP  A1302 (-3.6A)
None
None
 1.12A 1fkbA-5welA:
undetectable		 1fkbA-5welA:
7.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		7 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
TYR A 198
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
 0.66A 1fkbA-5xb0A:
15.4		 1fkbA-5xb0A:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		6 TYR A 147
PHE A 166
ILE A 172
TRP A 175
TYR A 198
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
 1.03A 1fkbA-5xb0A:
15.4		 1fkbA-5xb0A:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		5 TYR A 147
VAL A 171
TRP A 175
ILE A 207
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
 1.04A 1fkbA-5xb0A:
15.4		 1fkbA-5xb0A:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 9 TYR A  38
ASP A  49
PHE A  58
GLU A  66
VAL A  67
ILE A  68
TRP A  71
TYR A  94
PHE A 111
 None
 0.69A 1fkbA-6b4pA:
19.6		 1fkbA-6b4pA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 6 TYR A  38
ASP A  49
PHE A  58
GLU A  66
VAL A  67
ILE A 103
 None
 1.02A 1fkbA-6b4pA:
19.6		 1fkbA-6b4pA:
41.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
PHE A  58
TRP A  71
ILE A  99
PHE A 111
 None
 1.07A 1fkbA-6b4pA:
19.6		 1fkbA-6b4pA:
41.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 5 GLU A 318
VAL A 320
ILE A 321
TYR A 259
ILE A 256
 None
 1.12A 1fkbA-6cjqA:
undetectable		 1fkbA-6cjqA:
undetectable