SIMILAR PATTERNS OF AMINO ACIDS FOR 1FK6_A_LNLA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  53
LEU A  56
ALA A  24
LEU A  37
ALA A   7
 None
 1.03A 1fk6A-1bdmA:
undetectable		 1fk6A-1bdmA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f99 R-PHYCOCYANIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		5 LEU A 142
ALA A  40
LEU A  44
ALA A  48
ILE A 154
 None
 0.94A 1fk6A-1f99A:
undetectable		 1fk6A-1f99A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 VAL B 400
LEU B 403
ALA B 319
ALA B 365
ILE B 362
 None
 1.01A 1fk6A-1ffvB:
undetectable		 1fk6A-1ffvB:
9.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fk1 NON-SPECIFIC LIPID
TRANSFER PROTEIN

(Zea mays) 		PF00234
(Tryp_alpha_amyl) 		7 VAL A  33
ASN A  37
ARG A  46
ALA A  56
ILE A  71
ILE A  79
TYR A  81
 DAO  A 201 (-4.1A)
DAO  A 201 (-4.0A)
None
None
DAO  A 201 ( 4.0A)
DAO  A 201 ( 4.7A)
None
 1.08A 1fk6A-1fk1A:
21.7		 1fk6A-1fk1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fk1 NON-SPECIFIC LIPID
TRANSFER PROTEIN

(Zea mays) 		PF00234
(Tryp_alpha_amyl) 		12 VAL A  33
LEU A  36
ASN A  37
ALA A  40
ARG A  46
ALA A  49
LEU A  53
ALA A  57
ILE A  71
ILE A  79
TYR A  81
ILE A  83
 DAO  A 201 (-4.1A)
DAO  A 201 ( 4.6A)
DAO  A 201 (-4.0A)
DAO  A 201 ( 3.9A)
None
DAO  A 201 ( 4.0A)
None
None
DAO  A 201 ( 4.0A)
DAO  A 201 ( 4.7A)
None
FMT  A 205 ( 3.6A)
 0.36A 1fk6A-1fk1A:
21.7		 1fk6A-1fk1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 LEU A 209
ALA A 250
LEU A 246
ALA A 242
ILE A 222
 None
 1.04A 1fk6A-1fnnA:
undetectable		 1fk6A-1fnnA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 136
LEU A 139
ALA A 142
LEU A 165
ILE A 183
 None
 1.03A 1fk6A-1gwcA:
3.2		 1fk6A-1gwcA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 256
ARG A 125
LEU A 132
ALA A 136
ILE A 181
 None
 1.04A 1fk6A-1h0nA:
1.4		 1fk6A-1h0nA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		5 VAL C 548
LEU C 551
ALA C 555
ALA C 565
LEU C 566
 None
 1.02A 1fk6A-1h2tC:
1.9		 1fk6A-1h2tC:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A  15
ALA A  38
ALA A  49
ILE A  78
ILE A 116
 None
 0.84A 1fk6A-1m0sA:
undetectable		 1fk6A-1m0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		6 LEU A  66
ALA A   4
LEU A   6
ALA A  76
ILE A 113
ILE A  74
 None
 1.14A 1fk6A-1mldA:
undetectable		 1fk6A-1mldA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkv HYPOTHETICAL PROTEIN
YJHP

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 LEU A  51
ALA A  55
ARG A  87
ALA A 100
ILE A  91
 None
 0.80A 1fk6A-1nkvA:
undetectable		 1fk6A-1nkvA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 349
ALA A 267
LEU A 271
ALA A 275
ILE A 211
 PEG  A1401 ( 4.9A)
None
None
None
None
 0.97A 1fk6A-1ozhA:
0.5		 1fk6A-1ozhA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rli TRP REPRESSOR
BINDING PROTEIN

(Bacillus
subtilis) 		PF03358
(FMN_red) 		5 VAL A  18
LEU A  19
ASN A  15
ALA A 167
LEU A 168
 None
 0.84A 1fk6A-1rliA:
undetectable		 1fk6A-1rliA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0p ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN

(Dictyostelium
discoideum) 		PF01213
(CAP_N) 		5 VAL A 153
LEU A 213
ALA A  98
LEU A  94
ALA A  90
 None
 1.02A 1fk6A-1s0pA:
0.2		 1fk6A-1s0pA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uva NONSPECIFIC LIPID
TRANSFER PROTEIN 1

(Oryza sativa) 		PF00234
(Tryp_alpha_amyl) 		5 ALA A  38
ARG A  44
ALA A  47
LEU A  51
TYR A  79
 MYR  A 100 ( 4.4A)
MYR  A 100 (-4.4A)
None
MYR  A 100 ( 4.6A)
None
 0.70A 1fk6A-1uvaA:
17.4		 1fk6A-1uvaA:
78.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uva NONSPECIFIC LIPID
TRANSFER PROTEIN 1

(Oryza sativa) 		PF00234
(Tryp_alpha_amyl) 		6 VAL A  31
ALA A  38
ARG A  44
ALA A  47
LEU A  51
ALA A  55
 MYR  A 100 ( 4.1A)
MYR  A 100 ( 4.4A)
MYR  A 100 (-4.4A)
None
MYR  A 100 ( 4.6A)
None
 0.54A 1fk6A-1uvaA:
17.4		 1fk6A-1uvaA:
78.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uva NONSPECIFIC LIPID
TRANSFER PROTEIN 1

(Oryza sativa) 		PF00234
(Tryp_alpha_amyl) 		6 VAL A  31
ALA A  38
ARG A  44
ALA A  47
LEU A  51
ILE A  69
 MYR  A 100 ( 4.1A)
MYR  A 100 ( 4.4A)
MYR  A 100 (-4.4A)
None
MYR  A 100 ( 4.6A)
MYR  A 100 (-4.2A)
 0.53A 1fk6A-1uvaA:
17.4		 1fk6A-1uvaA:
78.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uva NONSPECIFIC LIPID
TRANSFER PROTEIN 1

(Oryza sativa) 		PF00234
(Tryp_alpha_amyl) 		6 VAL A  31
LEU A  34
ALA A  38
ALA A  47
LEU A  51
ALA A  55
 MYR  A 100 ( 4.1A)
MYR  A 100 ( 4.0A)
MYR  A 100 ( 4.4A)
None
MYR  A 100 ( 4.6A)
None
 0.60A 1fk6A-1uvaA:
17.4		 1fk6A-1uvaA:
78.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uva NONSPECIFIC LIPID
TRANSFER PROTEIN 1

(Oryza sativa) 		PF00234
(Tryp_alpha_amyl) 		6 VAL A  31
LEU A  34
ALA A  38
ALA A  47
LEU A  51
ILE A  69
 MYR  A 100 ( 4.1A)
MYR  A 100 ( 4.0A)
MYR  A 100 ( 4.4A)
None
MYR  A 100 ( 4.6A)
MYR  A 100 (-4.2A)
 0.55A 1fk6A-1uvaA:
17.4		 1fk6A-1uvaA:
78.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxz CELLULASE B

(Cellvibrio
mixtus) 		PF03422
(CBM_6) 		5 VAL A  61
ASN A 121
ALA A   8
ILE A  34
ILE A 113
 None
 0.95A 1fk6A-1uxzA:
undetectable		 1fk6A-1uxzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 247
ARG A 280
ALA A 260
ILE A 218
ILE A 267
 None
 0.93A 1fk6A-1vmaA:
undetectable		 1fk6A-1vmaA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a18 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 4

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		5 ALA A  65
ALA A  24
ILE A  79
ILE A  10
ILE A  48
 None
 0.86A 1fk6A-2a18A:
undetectable		 1fk6A-2a18A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9s DNA TOPOISOMERASE
I-LIKE PROTEIN
TOPOISOMERASE I-LIKE
PROTEIN

(Leishmania
donovani) 		PF01028
(Topoisom_I)
PF02919
(Topoisom_I_N)
PF14370
(Topo_C_assoc) 		5 VAL A 447
LEU A 450
ALA A 312
ALA A 273
ILE B 223
 None
 0.84A 1fk6A-2b9sA:
undetectable		 1fk6A-2b9sA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		5 VAL A 432
ASN A 428
ILE A 402
TYR A 456
ILE A 454
 None
 1.05A 1fk6A-2fgyA:
undetectable		 1fk6A-2fgyA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 VAL A 108
LEU A 111
ALA A 190
ALA A 147
ILE A 145
 None
 0.93A 1fk6A-2frxA:
undetectable		 1fk6A-2frxA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 ALA A 116
ALA A  73
LEU A  67
ILE A  84
ILE A  14
 None
 0.92A 1fk6A-2hrzA:
undetectable		 1fk6A-2hrzA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 LEU A 480
ARG A 475
ALA A 455
ALA A 398
ILE A 393
 None
 1.05A 1fk6A-2ja2A:
undetectable		 1fk6A-2ja2A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 LEU A 362
ALA A 286
LEU A 282
ALA A 278
ILE A 374
 None
 1.06A 1fk6A-2jh3A:
undetectable		 1fk6A-2jh3A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkd TRANSLATION
INITIATION FACTOR
IF-2

(Geobacillus
stearothermophilus) 		PF00009
(GTP_EFTU) 		5 LEU A  24
ALA A  27
ALA A 152
LEU A 150
ILE A 111
 None
None
GDP  A 179 (-3.1A)
None
None
 1.01A 1fk6A-2lkdA:
undetectable		 1fk6A-2lkdA:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n2z NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Anethum
graveolens) 		PF00234
(Tryp_alpha_amyl) 		5 LEU A  36
ASN A  37
ALA A  40
ALA A  49
ALA A  57
 None
 0.62A 1fk6A-2n2zA:
13.0		 1fk6A-2n2zA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n2z NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Anethum
graveolens) 		PF00234
(Tryp_alpha_amyl) 		5 VAL A  33
LEU A  36
ALA A  40
ARG A  46
ALA A  49
 None
 0.98A 1fk6A-2n2zA:
13.0		 1fk6A-2n2zA:
59.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n2z NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Anethum
graveolens) 		PF00234
(Tryp_alpha_amyl) 		5 VAL A  33
LEU A  36
ASN A  37
ALA A  40
ALA A  49
 None
 0.62A 1fk6A-2n2zA:
13.0		 1fk6A-2n2zA:
59.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		5 LEU A 176
ARG A 178
LEU A 184
ALA A 188
ILE A 213
 None
 0.92A 1fk6A-2olaA:
undetectable		 1fk6A-2olaA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 VAL A  41
LEU A  44
ALA A  48
LEU A 110
ILE A  70
 None
 0.87A 1fk6A-2ptsA:
undetectable		 1fk6A-2ptsA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 LEU A  15
ALA A  18
ALA A 107
ALA A  62
ILE A  59
 None
 1.02A 1fk6A-2qa2A:
undetectable		 1fk6A-2qa2A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 LEU A 231
ASN A 232
ILE A 226
TYR A 367
ILE A 224
 None
 0.96A 1fk6A-2qn0A:
undetectable		 1fk6A-2qn0A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		5 VAL A 289
ASN A 288
ALA A 282
LEU A 340
ALA A 344
 None
 1.04A 1fk6A-2vakA:
undetectable		 1fk6A-2vakA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		5 VAL A  50
LEU A  53
ALA A  56
ALA A 119
ILE A  26
 None
 1.02A 1fk6A-2wcvA:
undetectable		 1fk6A-2wcvA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 LEU A 348
ALA A 341
LEU A 255
ALA A 259
ILE A 291
 None
None
None
ADP  A 501 ( 4.6A)
None
 0.88A 1fk6A-2zkjA:
undetectable		 1fk6A-2zkjA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 ALA A 451
ALA A  66
ALA A  25
ILE A 417
ILE A 392
 None
 0.89A 1fk6A-2zxhA:
undetectable		 1fk6A-2zxhA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 LEU A  19
ALA A  85
LEU A  81
ILE A  40
ILE A  76
 None
 0.89A 1fk6A-3afgA:
undetectable		 1fk6A-3afgA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		5 VAL A 324
LEU A 327
ARG A 204
ALA A 208
LEU A 209
 None
EDO  A 358 ( 4.4A)
SO4  A 353 ( 3.9A)
None
None
 0.91A 1fk6A-3clmA:
undetectable		 1fk6A-3clmA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 LEU A 310
ALA A 391
LEU A 393
ALA A 395
ILE A 356
 None
 0.74A 1fk6A-3ek1A:
undetectable		 1fk6A-3ek1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 ALA B 180
ARG B  63
ALA B  67
LEU B  68
ILE B  13
 None
 0.80A 1fk6A-3h0rB:
undetectable		 1fk6A-3h0rB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzb CARBOHYDRATE BINDING
PROTEIN

(Flavobacterium
johnsoniae) 		no annotation 5 VAL A  33
LEU A  31
LEU A  18
ALA A  49
ILE A  38
 None
 0.98A 1fk6A-3hzbA:
undetectable		 1fk6A-3hzbA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN) 		5 ARG A  93
ALA A 303
ALA A 127
ILE A  92
ILE A 123
 None
 0.95A 1fk6A-3k8vA:
undetectable		 1fk6A-3k8vA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvs C-PHYCOCYANIN ALPHA
CHAIN

(Galdieria
sulphuraria) 		PF00502
(Phycobilisome) 		5 LEU A 142
ALA A  40
LEU A  44
ALA A  48
ILE A 154
 None
 0.95A 1fk6A-3kvsA:
undetectable		 1fk6A-3kvsA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lto MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Legionella
pneumophila) 		no annotation 5 ARG A 219
ALA A 222
LEU A 226
ALA A 230
ILE A 242
 None
 0.90A 1fk6A-3ltoA:
undetectable		 1fk6A-3ltoA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n07 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Vibrio cholerae) 		PF08282
(Hydrolase_3) 		5 VAL A 166
LEU A 169
ALA A 173
ILE A 120
ILE A  23
 None
 0.89A 1fk6A-3n07A:
undetectable		 1fk6A-3n07A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1u HYDROLASE, HAD
SUPERFAMILY,
SUBFAMILY III A

(Legionella
pneumophila) 		PF08282
(Hydrolase_3) 		5 LEU A 165
ALA A 169
ALA A 146
ILE A 116
ILE A  19
 None
 1.05A 1fk6A-3n1uA:
undetectable		 1fk6A-3n1uA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 VAL A 619
LEU A 622
ASN A 623
ALA A 626
ALA A 420
 None
 0.68A 1fk6A-3opyA:
undetectable		 1fk6A-3opyA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pet PUTATIVE ADHESIN

(Bacteroides
fragilis) 		PF10988
(DUF2807) 		5 LEU A 189
ASN A 207
ALA A 191
ALA A 174
LEU A 176
 None
 0.94A 1fk6A-3petA:
undetectable		 1fk6A-3petA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 LEU A 473
ALA A 158
LEU A 333
ILE A 463
ILE A 397
 None
 0.99A 1fk6A-3q88A:
undetectable		 1fk6A-3q88A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 VAL A  71
LEU A  72
ALA A 127
ALA A 123
LEU A  37
 None
 1.04A 1fk6A-3qplA:
undetectable		 1fk6A-3qplA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		5 ASN A  19
ALA A  22
LEU A  31
ALA A  33
ILE A  39
 None
 1.02A 1fk6A-3qvoA:
undetectable		 1fk6A-3qvoA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		5 VAL A  94
LEU A  95
ASN A  96
ALA A 133
ALA A 321
 None
 0.97A 1fk6A-3sz3A:
undetectable		 1fk6A-3sz3A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		5 LEU A  13
ALA A  83
LEU A  87
ALA A  91
ILE A 143
 None
 1.06A 1fk6A-3t7bA:
undetectable		 1fk6A-3t7bA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 LEU A  63
ARG A 395
ALA A 399
LEU A 400
ILE A 324
 None
 1.00A 1fk6A-3v5rA:
undetectable		 1fk6A-3v5rA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 430
ALA A 358
LEU A 362
ALA A 366
ILE A 380
 None
 0.75A 1fk6A-4atqA:
undetectable		 1fk6A-4atqA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsz ANKYRIN
REPEAT-CONTAINING
PROTEIN YAR1

(Saccharomyces
cerevisiae) 		PF12796
(Ank_2) 		5 LEU B 112
ALA B 100
ALA B  96
LEU B  54
ILE B  69
 None
 1.06A 1fk6A-4bszB:
undetectable		 1fk6A-4bszB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)

(Pseudomonas
stutzeri) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A  19
ARG A 306
ALA A 309
LEU A 313
ALA A 317
 None
 0.84A 1fk6A-4e5kA:
undetectable		 1fk6A-4e5kA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		5 LEU C 262
ALA B 240
LEU C 175
ILE C 225
ILE C 181
 None
 0.90A 1fk6A-4hr6C:
undetectable		 1fk6A-4hr6C:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jci PROLINE RACEMASE

(Chromohalobacter
salexigens) 		PF05544
(Pro_racemase) 		5 VAL A 167
LEU A 166
ALA A 158
ILE A 189
ILE A 206
 None
 1.02A 1fk6A-4jciA:
undetectable		 1fk6A-4jciA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmf EXOENZYME T
PROBABLE CHAPERONE

(Pseudomonas
aeruginosa) 		PF05932
(CesT)
no annotation 		5 LEU B  30
ALA A  59
LEU B  12
ALA B   8
ILE B 101
 None
 0.88A 1fk6A-4jmfB:
undetectable		 1fk6A-4jmfB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		5 VAL A 580
ALA A 587
LEU A 478
ILE A 532
ILE A 484
 None
 0.89A 1fk6A-4l22A:
undetectable		 1fk6A-4l22A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
cruzi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 ALA A  26
LEU A 329
ALA A 333
ILE A  35
ILE A  33
 None
 1.03A 1fk6A-4lsmA:
undetectable		 1fk6A-4lsmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 VAL A 571
ASN A 575
ALA A 578
LEU A 524
ALA A 522
 None
 0.87A 1fk6A-4m0mA:
undetectable		 1fk6A-4m0mA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 VAL A 571
LEU A 574
ASN A 575
LEU A 524
ALA A 522
 None
 0.83A 1fk6A-4m0mA:
undetectable		 1fk6A-4m0mA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		5 LEU A  97
ALA A 101
LEU A 229
ALA A 227
ILE A  49
 None
 0.87A 1fk6A-4or8A:
undetectable		 1fk6A-4or8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouq UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF16022
(DUF4783) 		5 LEU A  50
ALA A  64
LEU A  68
ILE A 107
ILE A 120
 None
 0.90A 1fk6A-4ouqA:
undetectable		 1fk6A-4ouqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		5 VAL A 100
LEU A 103
ALA A 107
ILE A 139
ILE A 177
 None
 0.86A 1fk6A-4pxbA:
undetectable		 1fk6A-4pxbA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 113
ALA A 147
ALA A 180
LEU A 183
ILE A  80
 None
 1.01A 1fk6A-4r16A:
undetectable		 1fk6A-4r16A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 ASN A 343
ALA A 348
LEU A 757
ALA A 800
ILE A 337
 None
 1.00A 1fk6A-4r7zA:
undetectable		 1fk6A-4r7zA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 ALA A 191
ALA A 291
LEU A 295
ALA A 299
ILE A 229
 None
 0.95A 1fk6A-4uplA:
undetectable		 1fk6A-4uplA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 VAL A 272
LEU A 273
ALA A 255
LEU A 259
ILE A 164
 None
 1.02A 1fk6A-4wuvA:
undetectable		 1fk6A-4wuvA:
16.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuw NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Corylus
avellana) 		PF00234
(Tryp_alpha_amyl) 		5 ARG A  68
LEU A  75
ALA A  79
ILE A 101
ILE A 105
 None
 0.89A 1fk6A-4xuwA:
15.7		 1fk6A-4xuwA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuw NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Corylus
avellana) 		PF00234
(Tryp_alpha_amyl) 		6 ASN A  59
ARG A  68
ALA A  71
LEU A  75
ALA A  79
ILE A 105
 None
 0.81A 1fk6A-4xuwA:
15.7		 1fk6A-4xuwA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuw NON-SPECIFIC
LIPID-TRANSFER
PROTEIN

(Corylus
avellana) 		PF00234
(Tryp_alpha_amyl) 		6 VAL A  55
ASN A  59
ARG A  68
ALA A  71
LEU A  75
ALA A  79
 None
 0.49A 1fk6A-4xuwA:
15.7		 1fk6A-4xuwA:
49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		5 LEU A  98
ALA A 132
LEU A 134
ILE A 115
ILE A 137
 None
 0.94A 1fk6A-4zi5A:
undetectable		 1fk6A-4zi5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A 228
LEU A 291
ALA A 295
ILE A  61
ILE A  49
 None
 0.74A 1fk6A-5dxiA:
undetectable		 1fk6A-5dxiA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 LEU A 678
ALA A 682
ARG A 659
LEU A 697
ALA A  48
 None
 1.00A 1fk6A-5e7pA:
undetectable		 1fk6A-5e7pA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE

(Thermus
thermophilus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A 146
ALA A 150
ALA A 240
ILE A 293
ILE A 310
 None
 1.04A 1fk6A-5eioA:
undetectable		 1fk6A-5eioA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl6 RIBOSOME MATURATION
FACTOR RIMP

(Mycolicibacterium
smegmatis) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		5 LEU A  97
ARG A 104
ALA A 106
LEU A 125
ALA A 123
 None
 0.98A 1fk6A-5gl6A:
undetectable		 1fk6A-5gl6A:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lqv NON-SPECIFIC
LIPID-TRANSFER
PROTEIN 2

(Lens culinaris) 		PF00234
(Tryp_alpha_amyl) 		5 ALA A  39
ARG A  45
ALA A  48
LEU A  52
ALA A  56
 PGM  A 101 ( 4.8A)
None
PGM  A 101 ( 3.9A)
PGM  A 101 (-3.1A)
PGM  A 101 (-2.7A)
 0.90A 1fk6A-5lqvA:
14.1		 1fk6A-5lqvA:
58.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lqv NON-SPECIFIC
LIPID-TRANSFER
PROTEIN 2

(Lens culinaris) 		PF00234
(Tryp_alpha_amyl) 		5 LEU A  35
ALA A  39
ALA A  48
LEU A  52
ALA A  56
 PGM  A 101 (-3.3A)
PGM  A 101 ( 4.8A)
PGM  A 101 ( 3.9A)
PGM  A 101 (-3.1A)
PGM  A 101 (-2.7A)
 0.76A 1fk6A-5lqvA:
14.1		 1fk6A-5lqvA:
58.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lqv NON-SPECIFIC
LIPID-TRANSFER
PROTEIN 2

(Lens culinaris) 		PF00234
(Tryp_alpha_amyl) 		5 VAL A  32
LEU A  35
ALA A  39
ALA A  48
LEU A  52
 None
PGM  A 101 (-3.3A)
PGM  A 101 ( 4.8A)
PGM  A 101 ( 3.9A)
PGM  A 101 (-3.1A)
 0.75A 1fk6A-5lqvA:
14.1		 1fk6A-5lqvA:
58.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 5 ASN A 231
ALA A 238
LEU A 242
ALA A 246
ILE A 216
 None
 0.76A 1fk6A-5obuA:
undetectable		 1fk6A-5obuA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 5 LEU A 260
ALA A  10
LEU A  24
ALA A  28
ILE A 321
 None
 1.03A 1fk6A-5or4A:
undetectable		 1fk6A-5or4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tev TRYPTOPHAN--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00579
(tRNA-synt_1b) 		5 VAL A  90
LEU A  93
ASN A  94
ALA A 151
ILE A 146
 None
 0.69A 1fk6A-5tevA:
undetectable		 1fk6A-5tevA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		5 VAL A 265
LEU A 268
ALA A 286
LEU A 255
ILE A 293
 None
 0.87A 1fk6A-5tjrA:
undetectable		 1fk6A-5tjrA:
9.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tvi NON SPECIFIC LIPID
TRANSFER PROTEIN

(Solanum
melongena) 		PF00234
(Tryp_alpha_amyl) 		6 VAL V  32
ASN V  36
ALA V  39
ARG V  45
ALA V  48
ALA V  56
 None
 0.66A 1fk6A-5tviV:
15.8		 1fk6A-5tviV:
44.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tvi NON SPECIFIC LIPID
TRANSFER PROTEIN

(Solanum
melongena) 		PF00234
(Tryp_alpha_amyl) 		6 VAL V  32
LEU V  35
ALA V  39
ARG V  45
ALA V  48
ALA V  56
 None
 0.79A 1fk6A-5tviV:
15.8		 1fk6A-5tviV:
44.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 VAL A  71
ALA A 363
ALA A 134
LEU A 296
ALA A 116
 None
 1.00A 1fk6A-5tvjA:
undetectable		 1fk6A-5tvjA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		5 LEU A  93
ALA A 118
ALA A 159
LEU A 160
ILE A  58
 None
 1.03A 1fk6A-5uygA:
undetectable		 1fk6A-5uygA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1s RADICAL SAM

(Streptococcus
suis) 		PF04055
(Radical_SAM)
PF13394
(Fer4_14) 		5 ALA A 174
LEU A 144
ALA A 147
ILE A 356
ILE A 157
 None
 0.83A 1fk6A-5v1sA:
undetectable		 1fk6A-5v1sA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y05 MSMEG_4306

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A  31
ASN A  30
LEU A 159
ALA A 162
ILE A  24
 None
 0.95A 1fk6A-5y05A:
undetectable		 1fk6A-5y05A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 5 VAL A  76
LEU A   6
ALA A  89
ILE A 125
ILE A  85
 None
 1.05A 1fk6A-6a31A:
undetectable		 1fk6A-6a31A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9k DARP14 - SUBUNIT A
WITH DARPIN

(synthetic
construct) 		no annotation 5 LEU A  34
ALA A 125
LEU A 146
ALA A 144
ILE A  79
 None
 1.07A 1fk6A-6c9kA:
undetectable		 1fk6A-6c9kA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 5 VAL A  94
LEU A  95
ASN A  96
ALA A 133
ALA A 317
 None
 0.99A 1fk6A-6dfuA:
undetectable		 1fk6A-6dfuA:
23.66