SIMILAR PATTERNS OF AMINO ACIDS FOR 1FJA_D_DVAD8
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aun | PR-5D (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 188THR A 190PRO A 187 | None | 0.75A | 1fjaD-1aunA:undetectable | 1fjaD-1aunA:4.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhg | BETA-GLUCURONIDASE (Homo sapiens) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 3 | THR A 223THR A 117PRO A 224 | None | 0.85A | 1fjaD-1bhgA:undetectable | 1fjaD-1bhgA:4.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bol | PROTEIN(RIBONUCLEASE RH) (Rhizopus niveus) |
PF00445(Ribonuclease_T2) | 3 | THR A 115THR A 18PRO A 22 | None | 0.88A | 1fjaD-1bolA:undetectable | 1fjaD-1bolA:5.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 3 | THR A 111THR A 109PRO A 107 | None | 0.68A | 1fjaD-1cptA:undetectable | 1fjaD-1cptA:5.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg1 | ENDOGLUCANASE I (Trichodermareesei) |
PF00840(Glyco_hydro_7) | 3 | THR A 7THR A 5PRO A 8 | None | 0.74A | 1fjaD-1eg1A:undetectable | 1fjaD-1eg1A:4.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eu1 | DIMETHYL SULFOXIDEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 3 | THR A 107THR A 109PRO A 106 | None | 0.80A | 1fjaD-1eu1A:undetectable | 1fjaD-1eu1A:1.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffv | CUTL, MOLYBDOPROTEINOF CARBON MONOXIDEDEHYDROGENASE (Hydrogenophagapseudoflava) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 3 | THR B 766THR B 768PRO B 765 | None | 0.85A | 1fjaD-1ffvB:undetectable | 1fjaD-1ffvB:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1he3 | BILIVERDIN IX BETAREDUCTASE (Homo sapiens) |
PF13460(NAD_binding_10) | 3 | THR A 199THR A 166PRO A 201 | None | 0.85A | 1fjaD-1he3A:undetectable | 1fjaD-1he3A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3e | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 70THR A 84PRO A 72 | None | 0.85A | 1fjaD-1j3eA:undetectable | 1fjaD-1j3eA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3u | ASPARTASE (Bacillus sp.YM55-1) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 3 | THR A 147THR A 149PRO A 146 | None | 0.87A | 1fjaD-1j3uA:undetectable | 1fjaD-1j3uA:2.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 3 | THR A 99THR A 97PRO A 95 | None | 0.72A | 1fjaD-1jioA:undetectable | 1fjaD-1jioA:7.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kj0 | SERINE PROTEASEINHIBITOR I (Schistocercagregaria) |
PF05375(Pacifastin_I) | 3 | THR A 20THR A 5PRO A 21 | None | 0.89A | 1fjaD-1kj0A:undetectable | 1fjaD-1kj0A:38.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrr | SEQA PROTEIN (Escherichiacoli) |
PF03925(SeqA) | 3 | THR A 135THR A 149PRO A 137 | None | 0.81A | 1fjaD-1lrrA:undetectable | 1fjaD-1lrrA:6.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 137THR A 139PRO A 136 | None | 0.86A | 1fjaD-1ml4A:undetectable | 1fjaD-1ml4A:3.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nwa | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA (Mycobacteriumtuberculosis) |
PF01625(PMSR) | 3 | THR A 61THR A 63PRO A 60 | None | 0.72A | 1fjaD-1nwaA:undetectable | 1fjaD-1nwaA:7.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pcv | OSMOTIN (Nicotianatabacum) |
PF00314(Thaumatin) | 3 | THR A 187THR A 189PRO A 186 | None | 0.87A | 1fjaD-1pcvA:undetectable | 1fjaD-1pcvA:5.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 3 | THR A1035THR A1032PRO A1034 | None | 0.66A | 1fjaD-1ux6A:undetectable | 1fjaD-1ux6A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlr | COAGULATION FACTORXI (Homo sapiens) |
PF00089(Trypsin) | 3 | THR A 37THR A 36PRO A 37 | None | 0.73A | 1fjaD-1zlrA:undetectable | 1fjaD-1zlrA:4.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME B (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B) | 3 | THR C 241THR C 37PRO C 36 | None | 0.89A | 1fjaD-1zrtC:undetectable | 1fjaD-1zrtC:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ad1 | SULFOTRANSFERASE 1C2 (Homo sapiens) |
PF00685(Sulfotransfer_1) | 3 | THR A 25THR A 23PRO A 22 | None | 0.88A | 1fjaD-2ad1A:undetectable | 1fjaD-2ad1A:4.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cl2 | PUTATIVELAMINARINASE (Phanerochaetechrysosporium) |
no annotation | 3 | THR A 98THR A 252PRO A 100 | None | 0.76A | 1fjaD-2cl2A:undetectable | 1fjaD-2cl2A:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gu0 | NONSTRUCTURALPROTEIN 2 (Rotavirus C) |
PF02509(Rota_NS35) | 3 | THR A 148THR A 152PRO A 150 | None | 0.86A | 1fjaD-2gu0A:undetectable | 1fjaD-2gu0A:3.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 3 | THR A 187THR A 185PRO A 154 | NonePLP A 400 (-3.6A)None | 0.86A | 1fjaD-2isqA:undetectable | 1fjaD-2isqA:4.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ljp | RIBONUCLEASE PPROTEIN COMPONENT (Escherichiacoli) |
PF00825(Ribonuclease_P) | 3 | THR A 30THR A 34PRO A 31 | None | 0.89A | 1fjaD-2ljpA:undetectable | 1fjaD-2ljpA:8.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oce | HYPOTHETICAL PROTEINPA5201 (Pseudomonasaeruginosa) |
PF00575(S1)PF09371(Tex_N)PF12836(HHH_3)PF16921(Tex_YqgF) | 3 | THR A 618THR A 620PRO A 617 | None | 0.89A | 1fjaD-2oceA:undetectable | 1fjaD-2oceA:2.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q09 | IMIDAZOLONEPROPIONASE (unidentified) |
PF01979(Amidohydro_1) | 3 | THR A 16THR A 65PRO A 14 | None | 0.78A | 1fjaD-2q09A:undetectable | 1fjaD-2q09A:3.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7z | HEAT SHOCK COGNATE71 KDA PROTEIN (Rattusnorvegicus) |
PF00012(HSP70) | 3 | THR A 64THR A 66PRO A 63 | None | 0.82A | 1fjaD-2v7zA:undetectable | 1fjaD-2v7zA:3.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9q | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 3 | THR A 228THR A 230PRO A 186 | None | 0.84A | 1fjaD-2v9qA:undetectable | 1fjaD-2v9qA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vaw | CELL DIVISIONPROTEIN FTSZ (Pseudomonasaeruginosa) |
PF00091(Tubulin)PF12327(FtsZ_C) | 3 | THR A 111THR A 109PRO A 75 | NoneGDP A1317 (-4.0A)None | 0.87A | 1fjaD-2vawA:undetectable | 1fjaD-2vawA:4.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w7q | OUTER-MEMBRANELIPOPROTEIN CARRIERPROTEIN (Pseudomonasaeruginosa) |
PF03548(LolA) | 3 | THR A 108THR A 106PRO A 109 | None | 0.88A | 1fjaD-2w7qA:undetectable | 1fjaD-2w7qA:4.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 3 | THR A 276THR A 278PRO A 274 | NoneNoneFAD A 600 ( 4.9A) | 0.84A | 1fjaD-2z5xA:undetectable | 1fjaD-2z5xA:1.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dao | PUTATIVE PHOSPHATE ([Eubacterium]rectale) |
PF08282(Hydrolase_3) | 3 | THR A 80THR A 69PRO A 82 | None | 0.87A | 1fjaD-3daoA:undetectable | 1fjaD-3daoA:9.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djd | FRUCTOSYL AMINE:OXYGENOXIDOREDUCTASE (Aspergillusfumigatus) |
PF01266(DAO) | 3 | THR A 182THR A 180PRO A 38 | NoneNoneFAD A 500 (-4.3A) | 0.84A | 1fjaD-3djdA:undetectable | 1fjaD-3djdA:3.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg6 | ADSEVERIN (Homo sapiens) |
PF00626(Gelsolin) | 3 | THR A 702THR A 704PRO A 700 | None | 0.84A | 1fjaD-3fg6A:undetectable | 1fjaD-3fg6A:3.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmt | PROTEIN SEQA (Escherichiacoli) |
PF03925(SeqA)PF17206(SeqA_N) | 3 | THR A 135THR A 149PRO A 137 | None | 0.83A | 1fjaD-3fmtA:undetectable | 1fjaD-3fmtA:5.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gle | PILIN (Streptococcuspyogenes) |
PF12892(FctA) | 3 | THR A 50THR A 84PRO A 48 | THR A 50 ( 0.8A)THR A 84 ( 0.8A)PRO A 48 ( 1.1A) | 0.79A | 1fjaD-3gleA:undetectable | 1fjaD-3gleA:9.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1q | ETHANOLAMINEUTILIZATION PROTEINEUTJ (Carboxydothermushydrogenoformans) |
PF14450(FtsA) | 3 | THR A 147THR A 166PRO A 165 | None | 0.86A | 1fjaD-3h1qA:undetectable | 1fjaD-3h1qA:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5l | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Ruegeriapomeroyi) |
PF13458(Peripla_BP_6) | 3 | THR A 395THR A 397PRO A 394 | None | 0.82A | 1fjaD-3h5lA:undetectable | 1fjaD-3h5lA:4.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 3 | THR A 636THR A 638PRO A 635 | None | 0.77A | 1fjaD-3ikmA:undetectable | 1fjaD-3ikmA:0.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iq2 | SORTING NEXIN-7 (Homo sapiens) |
PF00787(PX) | 3 | THR A 133THR A 135PRO A 132 | None | 0.89A | 1fjaD-3iq2A:undetectable | 1fjaD-3iq2A:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV ALPHA CHAIN (Escherichiacoli) |
PF13538(UvrD_C_2)PF13604(AAA_30) | 3 | THR D 205THR D 239PRO D 204 | None | 0.80A | 1fjaD-3k70D:undetectable | 1fjaD-3k70D:2.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 3 | THR A 122THR A 124PRO A 121 | CL A 465 (-4.1A)None CL A 465 (-4.1A) | 0.78A | 1fjaD-3k9dA:undetectable | 1fjaD-3k9dA:3.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krv | HYDROLASE (Geobacillusstearothermophilus) |
PF04199(Cyclase) | 3 | THR A 46THR A 48PRO A 195 | None | 0.77A | 1fjaD-3krvA:undetectable | 1fjaD-3krvA:5.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxm | ASPARTATECARBAMOYLTRANSFERASE (Yersinia pestis) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | THR A 137THR A 139PRO A 136 | None | 0.80A | 1fjaD-3lxmA:undetectable | 1fjaD-3lxmA:3.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my7 | ALCOHOLDEHYDROGENASE/ACETALDEHYDE DEHYDROGENASE (Vibrioparahaemolyticus) |
PF00171(Aldedh) | 3 | THR A 117THR A 119PRO A 116 | CL A 453 ( 4.4A)None CL A 453 ( 4.6A) | 0.82A | 1fjaD-3my7A:undetectable | 1fjaD-3my7A:3.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nz4 | PHENYLALANINEAMMONIA-LYASE (Taxuscanadensis) |
PF00221(Lyase_aromatic) | 3 | THR A 127THR A 129PRO A 125 | None | 0.79A | 1fjaD-3nz4A:undetectable | 1fjaD-3nz4A:1.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p40 | NEUROFASCIN (Homo sapiens) |
PF13927(Ig_3) | 3 | THR A 410THR A 367PRO A 366 | None | 0.87A | 1fjaD-3p40A:undetectable | 1fjaD-3p40A:2.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pic | CIP2 (Trichodermareesei) |
no annotation | 3 | THR A 297THR A 275PRO A 299 | None | 0.85A | 1fjaD-3picA:undetectable | 1fjaD-3picA:4.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 3 | THR A 268THR A 270PRO A 266 | None | 0.88A | 1fjaD-3q1yA:undetectable | 1fjaD-3q1yA:5.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh9 | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE(NAD(P)(+)) (Marinobacterhydrocarbonoclasticus) |
PF00171(Aldedh) | 3 | THR A 477THR A 140PRO A 479 | None | 0.87A | 1fjaD-3rh9A:undetectable | 1fjaD-3rh9A:2.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sc2 | SERINECARBOXYPEPTIDASE II(CPDW-II) (Triticumaestivum) |
PF00450(Peptidase_S10) | 3 | THR B 344THR B 346PRO B 342 | None | 0.79A | 1fjaD-3sc2B:undetectable | 1fjaD-3sc2B:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdy | BETA-1,3-1,4-GLUCANASE (Paecilomycessp.'thermophila') |
no annotation | 3 | THR A 96THR A 248PRO A 98 | None | 0.81A | 1fjaD-3wdyA:undetectable | 1fjaD-3wdyA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4av6 | K(+)-STIMULATEDPYROPHOSPHATE-ENERGIZED SODIUM PUMP (Thermotogamaritima) |
PF03030(H_PPase) | 3 | THR A 421THR A 423PRO A 420 | None | 0.85A | 1fjaD-4av6A:undetectable | 1fjaD-4av6A:2.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btp | P1 (Pseudomonasphage phi8) |
no annotation | 3 | THR A 295THR A 297PRO A 299 | None | 0.78A | 1fjaD-4btpA:undetectable | 1fjaD-4btpA:3.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 3 | THR A 650THR A 647PRO A 649 | None | 0.62A | 1fjaD-4byfA:undetectable | 1fjaD-4byfA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eog | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09455(Cas_DxTHG) | 3 | THR A 174THR A 176PRO A 173 | None | 0.88A | 1fjaD-4eogA:undetectable | 1fjaD-4eogA:5.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1h | TYROSYL-DNAPHOSPHODIESTERASE 2 (Danio rerio) |
PF03372(Exo_endo_phos) | 3 | THR A 210THR A 211PRO A 209 | None | 0.87A | 1fjaD-4f1hA:undetectable | 1fjaD-4f1hA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4i | 4-O-METHYL-GLUCURONOYL METHYLESTERASE (Thermothelomycesthermophila) |
no annotation | 3 | THR A 232THR A 210PRO A 234 | None | 0.84A | 1fjaD-4g4iA:undetectable | 1fjaD-4g4iA:3.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwi | HEAT SHOCK COGNATE71 KDA PROTEIN (Homo sapiens) |
PF00012(HSP70) | 3 | THR A 64THR A 66PRO A 63 | None | 0.88A | 1fjaD-4hwiA:undetectable | 1fjaD-4hwiA:5.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jru | THAUMATIN-LIKEPROTEIN (Vitis vinifera) |
PF00314(Thaumatin) | 3 | THR A 86THR A 100PRO A 102 | None | 0.86A | 1fjaD-4jruA:undetectable | 1fjaD-4jruA:7.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l27 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
no annotation | 3 | THR B 262THR B 260PRO B 229 | NonePLP B 601 (-3.3A)HEM B 602 (-4.0A) | 0.87A | 1fjaD-4l27B:undetectable | 1fjaD-4l27B:2.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l2j | OSMOTIN: ANTIFUNGALLATICIFER PROTEIN (Calotropisprocera) |
PF00314(Thaumatin) | 3 | THR A 187THR A 189PRO A 186 | None | 0.77A | 1fjaD-4l2jA:undetectable | 1fjaD-4l2jA:3.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldz | TRANSCRIPTIONALREGULATORY PROTEINDESR (Bacillussubtilis) |
PF00072(Response_reg)PF00196(GerE) | 3 | THR A 35THR A 61PRO A 58 | None | 0.86A | 1fjaD-4ldzA:undetectable | 1fjaD-4ldzA:7.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lmp | ALANINEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF01262(AlaDh_PNT_C)PF05222(AlaDh_PNT_N) | 3 | THR A 310THR A 308PRO A 306 | None | 0.83A | 1fjaD-4lmpA:undetectable | 1fjaD-4lmpA:4.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mqd | DNA-ENTRY NUCLEASEINHIBITOR (Bacillussubtilis) |
PF11033(ComJ) | 3 | THR A 112THR A 124PRO A 114 | None | 0.79A | 1fjaD-4mqdA:undetectable | 1fjaD-4mqdA:7.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov4 | 2-ISOPROPYLMALATESYNTHASE (Leptospirabiflexa) |
PF00682(HMGL-like) | 3 | THR A 178THR A 208PRO A 176 | KIV A 402 (-2.8A)NoneKIV A 402 (-4.2A) | 0.74A | 1fjaD-4ov4A:undetectable | 1fjaD-4ov4A:2.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovj | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Alicyclobacillusacidocaldarius) |
PF13416(SBP_bac_8) | 3 | THR A 257THR A 259PRO A 255 | None | 0.83A | 1fjaD-4ovjA:undetectable | 1fjaD-4ovjA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ry1 | PERIPLASMIC SOLUTEBINDING PROTEIN (Pectobacteriumatrosepticum) |
PF13416(SBP_bac_8) | 3 | THR A 165THR A 301PRO A 303 | None | 0.88A | 1fjaD-4ry1A:undetectable | 1fjaD-4ry1A:3.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3j | CORTICAL-LYTICENZYME (Bacillus cereus) |
PF00704(Glyco_hydro_18)PF01476(LysM) | 3 | THR A 162THR A 166PRO A 168 | None | 0.89A | 1fjaD-4s3jA:undetectable | 1fjaD-4s3jA:2.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u16 | MUSCARINICACETYLCHOLINERECEPTORM3,LYSOZYME,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Rattusnorvegicus;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | THR A 229THR A 231PRO A 228 | None | 0.88A | 1fjaD-4u16A:undetectable | 1fjaD-4u16A:4.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u39 | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 3 | THR A 111THR A 109PRO A 75 | NonePO4 A 401 (-4.1A)None | 0.88A | 1fjaD-4u39A:undetectable | 1fjaD-4u39A:4.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uu9 | MEDI7814 (Homo sapiens) |
PF07686(V-set) | 3 | THR B 94THR B 95PRO B 93 | None | 0.78A | 1fjaD-4uu9B:undetectable | 1fjaD-4uu9B:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzb | NITROGENASEMOLYBDENUM-IRONPROTEIN ALPHA CHAIN (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 3 | THR A 303THR A 305PRO A 302 | None | 0.84A | 1fjaD-4wzbA:undetectable | 1fjaD-4wzbA:4.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvh | CARBOHYDRATEESTERASE FAMILY 2(CE2) (Chaetomium) |
PF13472(Lipase_GDSL_2) | 3 | THR A 288THR A 285PRO A 287 | None | 0.52A | 1fjaD-4xvhA:undetectable | 1fjaD-4xvhA:3.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ac9 | VP1 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 3 | THR 1 68THR 1 70PRO 1 188 | None | 0.83A | 1fjaD-5ac91:undetectable | 1fjaD-5ac91:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bw8 | UBIQUITIN-LIKEPROTEIN MDY2 (Saccharomycescerevisiae) |
PF16843(Get5_bdg) | 3 | THR D 21THR D 23PRO D 25 | None | 0.85A | 1fjaD-5bw8D:undetectable | 1fjaD-5bw8D:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwy | PLASMEPSIN-2 (Plasmodiumfalciparum) |
PF00026(Asp) | 3 | THR A 114THR A 116PRO A 113 | None | 0.64A | 1fjaD-5bwyA:undetectable | 1fjaD-5bwyA:2.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 3 | THR D1944THR D1946PRO D1943 | None | 0.68A | 1fjaD-5disD:undetectable | 1fjaD-5disD:2.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dyn | PUTATIVE PEPTIDASE (Bacteroidesfragilis) |
PF03415(Peptidase_C11) | 3 | THR B 388THR B 282PRO B 278 | None | 0.85A | 1fjaD-5dynB:undetectable | 1fjaD-5dynB:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7o | DMSO REDUCTASEFAMILY TYPE IIENZYME, IRON-SULFURSUBUNIT (Azospira oryzae) |
PF13247(Fer4_11) | 3 | THR B 252THR B 141PRO B 254 | SF4 B 403 ( 4.9A)NoneNone | 0.83A | 1fjaD-5e7oB:undetectable | 1fjaD-5e7oB:4.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eod | COAGULATION FACTORXI (Homo sapiens) |
PF00024(PAN_1)PF00089(Trypsin) | 3 | THR A 393THR A 390PRO A 392 | None | 0.66A | 1fjaD-5eodA:undetectable | 1fjaD-5eodA:1.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5has | SEC7 (Thielaviaterrestris) |
PF12783(Sec7_N)PF16213(DCB) | 3 | THR A 66THR A 64PRO A 62 | None | 0.67A | 1fjaD-5hasA:undetectable | 1fjaD-5hasA:2.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs8 | HTH-TYPETRANSCRIPTIONALREGULATOR YODB (Bacillussubtilis) |
PF01638(HxlR) | 3 | THR A 41THR A 39PRO A 43 | None | 0.79A | 1fjaD-5hs8A:undetectable | 1fjaD-5hs8A:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ify | GLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Burkholderiavietnamiensis) |
PF00483(NTP_transferase) | 3 | THR A 81THR A 56PRO A 83 | None | 0.88A | 1fjaD-5ifyA:undetectable | 1fjaD-5ifyA:6.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j78 | ACETALDEHYDEDEHYDROGENASE(ACETYLATING) (Parageobacillusthermoglucosidasius) |
PF00171(Aldedh) | 3 | THR A 144THR A 146PRO A 143 | ACT A1005 (-3.3A)NoneACT A1005 (-3.9A) | 0.75A | 1fjaD-5j78A:undetectable | 1fjaD-5j78A:2.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 3 | THR A 197THR A 195PRO A 200 | 1VU A 601 ( 4.8A)NoneNone | 0.89A | 1fjaD-5jfmA:undetectable | 1fjaD-5jfmA:3.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 3 | THR A 201THR A 203PRO A 200 | None | 0.77A | 1fjaD-5jfmA:undetectable | 1fjaD-5jfmA:3.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0y | EUKARYOTICTRANSLATIONINITIATION FACTOR 2SUBUNIT 1 (Oryctolaguscuniculus) |
PF00575(S1)PF07541(EIF_2_alpha) | 3 | THR P 222THR P 220PRO P 224 | None | 0.87A | 1fjaD-5k0yP:undetectable | 1fjaD-5k0yP:4.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nmp | ISATIN HYDROLASE (Ralstoniasolanacearum) |
no annotation | 3 | THR A 75THR A 77PRO A 255 | None | 0.76A | 1fjaD-5nmpA:undetectable | 1fjaD-5nmpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnb | ISATIN HYDROLASE A (Labrenziaaggregata) |
no annotation | 3 | THR A 70THR A 72PRO A 248 | None | 0.88A | 1fjaD-5nnbA:undetectable | 1fjaD-5nnbA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | GENERALTRANSCRIPTION FACTORIIH SUBUNIT4,P52,GENERALTRANSCRIPTION FACTORIIH SUBUNIT 4 (Homo sapiens) |
no annotation | 3 | THR D 386THR D 388PRO D 385 | None | 0.83A | 1fjaD-5of4D:undetectable | 1fjaD-5of4D:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tte | E3 UBIQUITIN-PROTEINLIGASE ARIH1 (Homo sapiens) |
PF01485(IBR) | 3 | THR B 129THR B 131PRO B 127 | None | 0.80A | 1fjaD-5tteB:undetectable | 1fjaD-5tteB:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0a | GLUCANASE (Trichodermaharzianum) |
no annotation | 3 | THR A 7THR A 5PRO A 8 | THR A 7 ( 0.8A)THR A 5 ( 0.8A)PRO A 8 ( 1.1A) | 0.77A | 1fjaD-5w0aA:undetectable | 1fjaD-5w0aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 3 | THR A 505THR A 502PRO A 504 | None | 0.67A | 1fjaD-5w1uA:undetectable | 1fjaD-5w1uA:2.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xb0 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF00254(FKBP_C) | 3 | THR A 184THR A 133PRO A 135 | None | 0.89A | 1fjaD-5xb0A:undetectable | 1fjaD-5xb0A:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF01257(2Fe-2S_thioredx)PF01512(Complex1_51K)PF10589(NADH_4Fe-4S) | 3 | THR A 212THR A 210PRO A 209 | None | 0.88A | 1fjaD-5xfaA:undetectable | 1fjaD-5xfaA:2.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhv | POLY [ADP-RIBOSE]POLYMERASE 1 (Homo sapiens) |
no annotation | 3 | THR A 821THR A 973PRO A 956 | None | 0.87A | 1fjaD-6bhvA:undetectable | 1fjaD-6bhvA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 3 | THR A1074THR A1076PRO A1073 | None | 0.88A | 1fjaD-6bq1A:undetectable | 1fjaD-6bq1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dll | P-HYDROXYBENZOATEHYDROXYLASE (Pseudomonasputida) |
no annotation | 3 | THR A 192THR A 217PRO A 193 | None | 0.83A | 1fjaD-6dllA:undetectable | 1fjaD-6dllA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 3 | THR A1826THR A1828PRO A1820 | None | 0.84A | 1fjaD-6fb3A:undetectable | 1fjaD-6fb3A:undetectable |