SIMILAR PATTERNS OF AMINO ACIDS FOR 1FJA_D_DVAD8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 THR A 188
THR A 190
PRO A 187
None
0.75A 1fjaD-1aunA:
undetectable
1fjaD-1aunA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
3 THR A 223
THR A 117
PRO A 224
None
0.85A 1fjaD-1bhgA:
undetectable
1fjaD-1bhgA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bol PROTEIN
(RIBONUCLEASE RH)


(Rhizopus niveus)
PF00445
(Ribonuclease_T2)
3 THR A 115
THR A  18
PRO A  22
None
0.88A 1fjaD-1bolA:
undetectable
1fjaD-1bolA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
3 THR A 111
THR A 109
PRO A 107
None
0.68A 1fjaD-1cptA:
undetectable
1fjaD-1cptA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
3 THR A   7
THR A   5
PRO A   8
None
0.74A 1fjaD-1eg1A:
undetectable
1fjaD-1eg1A:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE


(Rhodobacter
sphaeroides)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
3 THR A 107
THR A 109
PRO A 106
None
0.80A 1fjaD-1eu1A:
undetectable
1fjaD-1eu1A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
3 THR B 766
THR B 768
PRO B 765
None
0.85A 1fjaD-1ffvB:
undetectable
1fjaD-1ffvB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE


(Homo sapiens)
PF13460
(NAD_binding_10)
3 THR A 199
THR A 166
PRO A 201
None
0.85A 1fjaD-1he3A:
undetectable
1fjaD-1he3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
3 THR A  70
THR A  84
PRO A  72
None
0.85A 1fjaD-1j3eA:
undetectable
1fjaD-1j3eA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
3 THR A 147
THR A 149
PRO A 146
None
0.87A 1fjaD-1j3uA:
undetectable
1fjaD-1j3uA:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
3 THR A  99
THR A  97
PRO A  95
None
0.72A 1fjaD-1jioA:
undetectable
1fjaD-1jioA:
7.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kj0 SERINE PROTEASE
INHIBITOR I


(Schistocerca
gregaria)
PF05375
(Pacifastin_I)
3 THR A  20
THR A   5
PRO A  21
None
0.89A 1fjaD-1kj0A:
undetectable
1fjaD-1kj0A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrr SEQA PROTEIN

(Escherichia
coli)
PF03925
(SeqA)
3 THR A 135
THR A 149
PRO A 137
None
0.81A 1fjaD-1lrrA:
undetectable
1fjaD-1lrrA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE


(Pyrococcus
abyssi)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 137
THR A 139
PRO A 136
None
0.86A 1fjaD-1ml4A:
undetectable
1fjaD-1ml4A:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA


(Mycobacterium
tuberculosis)
PF01625
(PMSR)
3 THR A  61
THR A  63
PRO A  60
None
0.72A 1fjaD-1nwaA:
undetectable
1fjaD-1nwaA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcv OSMOTIN

(Nicotiana
tabacum)
PF00314
(Thaumatin)
3 THR A 187
THR A 189
PRO A 186
None
0.87A 1fjaD-1pcvA:
undetectable
1fjaD-1pcvA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
3 THR A1035
THR A1032
PRO A1034
None
0.66A 1fjaD-1ux6A:
undetectable
1fjaD-1ux6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
3 THR A  37
THR A  36
PRO A  37
None
0.73A 1fjaD-1zlrA:
undetectable
1fjaD-1zlrA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
3 THR C 241
THR C  37
PRO C  36
None
0.89A 1fjaD-1zrtC:
undetectable
1fjaD-1zrtC:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ad1 SULFOTRANSFERASE 1C2

(Homo sapiens)
PF00685
(Sulfotransfer_1)
3 THR A  25
THR A  23
PRO A  22
None
0.88A 1fjaD-2ad1A:
undetectable
1fjaD-2ad1A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 3 THR A  98
THR A 252
PRO A 100
None
0.76A 1fjaD-2cl2A:
undetectable
1fjaD-2cl2A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2


(Rotavirus C)
PF02509
(Rota_NS35)
3 THR A 148
THR A 152
PRO A 150
None
0.86A 1fjaD-2gu0A:
undetectable
1fjaD-2gu0A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
3 THR A 187
THR A 185
PRO A 154
None
PLP  A 400 (-3.6A)
None
0.86A 1fjaD-2isqA:
undetectable
1fjaD-2isqA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljp RIBONUCLEASE P
PROTEIN COMPONENT


(Escherichia
coli)
PF00825
(Ribonuclease_P)
3 THR A  30
THR A  34
PRO A  31
None
0.89A 1fjaD-2ljpA:
undetectable
1fjaD-2ljpA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201


(Pseudomonas
aeruginosa)
PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF)
3 THR A 618
THR A 620
PRO A 617
None
0.89A 1fjaD-2oceA:
undetectable
1fjaD-2oceA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E


(unidentified)
PF01979
(Amidohydro_1)
3 THR A  16
THR A  65
PRO A  14
None
0.78A 1fjaD-2q09A:
undetectable
1fjaD-2q09A:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN


(Rattus
norvegicus)
PF00012
(HSP70)
3 THR A  64
THR A  66
PRO A  63
None
0.82A 1fjaD-2v7zA:
undetectable
1fjaD-2v7zA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A 228
THR A 230
PRO A 186
None
0.84A 1fjaD-2v9qA:
undetectable
1fjaD-2v9qA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ


(Pseudomonas
aeruginosa)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR A 111
THR A 109
PRO A  75
None
GDP  A1317 (-4.0A)
None
0.87A 1fjaD-2vawA:
undetectable
1fjaD-2vawA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7q OUTER-MEMBRANE
LIPOPROTEIN CARRIER
PROTEIN


(Pseudomonas
aeruginosa)
PF03548
(LolA)
3 THR A 108
THR A 106
PRO A 109
None
0.88A 1fjaD-2w7qA:
undetectable
1fjaD-2w7qA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A


(Homo sapiens)
PF01593
(Amino_oxidase)
3 THR A 276
THR A 278
PRO A 274
None
None
FAD  A 600 ( 4.9A)
0.84A 1fjaD-2z5xA:
undetectable
1fjaD-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dao PUTATIVE PHOSPHATE

([Eubacterium]
rectale)
PF08282
(Hydrolase_3)
3 THR A  80
THR A  69
PRO A  82
None
0.87A 1fjaD-3daoA:
undetectable
1fjaD-3daoA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE


(Aspergillus
fumigatus)
PF01266
(DAO)
3 THR A 182
THR A 180
PRO A  38
None
None
FAD  A 500 (-4.3A)
0.84A 1fjaD-3djdA:
undetectable
1fjaD-3djdA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
3 THR A 702
THR A 704
PRO A 700
None
0.84A 1fjaD-3fg6A:
undetectable
1fjaD-3fg6A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmt PROTEIN SEQA

(Escherichia
coli)
PF03925
(SeqA)
PF17206
(SeqA_N)
3 THR A 135
THR A 149
PRO A 137
None
0.83A 1fjaD-3fmtA:
undetectable
1fjaD-3fmtA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes)
PF12892
(FctA)
3 THR A  50
THR A  84
PRO A  48
THR  A  50 ( 0.8A)
THR  A  84 ( 0.8A)
PRO  A  48 ( 1.1A)
0.79A 1fjaD-3gleA:
undetectable
1fjaD-3gleA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ


(Carboxydothermus
hydrogenoformans)
PF14450
(FtsA)
3 THR A 147
THR A 166
PRO A 165
None
0.86A 1fjaD-3h1qA:
undetectable
1fjaD-3h1qA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Ruegeria
pomeroyi)
PF13458
(Peripla_BP_6)
3 THR A 395
THR A 397
PRO A 394
None
0.82A 1fjaD-3h5lA:
undetectable
1fjaD-3h5lA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
3 THR A 636
THR A 638
PRO A 635
None
0.77A 1fjaD-3ikmA:
undetectable
1fjaD-3ikmA:
0.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq2 SORTING NEXIN-7

(Homo sapiens)
PF00787
(PX)
3 THR A 133
THR A 135
PRO A 132
None
0.89A 1fjaD-3iq2A:
undetectable
1fjaD-3iq2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN


(Escherichia
coli)
PF13538
(UvrD_C_2)
PF13604
(AAA_30)
3 THR D 205
THR D 239
PRO D 204
None
0.80A 1fjaD-3k70D:
undetectable
1fjaD-3k70D:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE


(Listeria
monocytogenes)
PF00171
(Aldedh)
3 THR A 122
THR A 124
PRO A 121
CL  A 465 (-4.1A)
None
CL  A 465 (-4.1A)
0.78A 1fjaD-3k9dA:
undetectable
1fjaD-3k9dA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krv HYDROLASE

(Geobacillus
stearothermophilus)
PF04199
(Cyclase)
3 THR A  46
THR A  48
PRO A 195
None
0.77A 1fjaD-3krvA:
undetectable
1fjaD-3krvA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 THR A 137
THR A 139
PRO A 136
None
0.80A 1fjaD-3lxmA:
undetectable
1fjaD-3lxmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE


(Vibrio
parahaemolyticus)
PF00171
(Aldedh)
3 THR A 117
THR A 119
PRO A 116
CL  A 453 ( 4.4A)
None
CL  A 453 ( 4.6A)
0.82A 1fjaD-3my7A:
undetectable
1fjaD-3my7A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
3 THR A 127
THR A 129
PRO A 125
None
0.79A 1fjaD-3nz4A:
undetectable
1fjaD-3nz4A:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p40 NEUROFASCIN

(Homo sapiens)
PF13927
(Ig_3)
3 THR A 410
THR A 367
PRO A 366
None
0.87A 1fjaD-3p40A:
undetectable
1fjaD-3p40A:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pic CIP2

(Trichoderma
reesei)
no annotation 3 THR A 297
THR A 275
PRO A 299
None
0.85A 1fjaD-3picA:
undetectable
1fjaD-3picA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua)
PF00294
(PfkB)
3 THR A 268
THR A 270
PRO A 266
None
0.88A 1fjaD-3q1yA:
undetectable
1fjaD-3q1yA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))


(Marinobacter
hydrocarbonoclasticus)
PF00171
(Aldedh)
3 THR A 477
THR A 140
PRO A 479
None
0.87A 1fjaD-3rh9A:
undetectable
1fjaD-3rh9A:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc2 SERINE
CARBOXYPEPTIDASE II
(CPDW-II)


(Triticum
aestivum)
PF00450
(Peptidase_S10)
3 THR B 344
THR B 346
PRO B 342
None
0.79A 1fjaD-3sc2B:
undetectable
1fjaD-3sc2B:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE


(Paecilomyces
sp.
'thermophila')
no annotation 3 THR A  96
THR A 248
PRO A  98
None
0.81A 1fjaD-3wdyA:
undetectable
1fjaD-3wdyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP


(Thermotoga
maritima)
PF03030
(H_PPase)
3 THR A 421
THR A 423
PRO A 420
None
0.85A 1fjaD-4av6A:
undetectable
1fjaD-4av6A:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8)
no annotation 3 THR A 295
THR A 297
PRO A 299
None
0.78A 1fjaD-4btpA:
undetectable
1fjaD-4btpA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC


(Homo sapiens)
PF00063
(Myosin_head)
PF00612
(IQ)
3 THR A 650
THR A 647
PRO A 649
None
0.62A 1fjaD-4byfA:
undetectable
1fjaD-4byfA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pyrococcus
furiosus)
PF09455
(Cas_DxTHG)
3 THR A 174
THR A 176
PRO A 173
None
0.88A 1fjaD-4eogA:
undetectable
1fjaD-4eogA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1h TYROSYL-DNA
PHOSPHODIESTERASE 2


(Danio rerio)
PF03372
(Exo_endo_phos)
3 THR A 210
THR A 211
PRO A 209
None
0.87A 1fjaD-4f1hA:
undetectable
1fjaD-4f1hA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE


(Thermothelomyces
thermophila)
no annotation 3 THR A 232
THR A 210
PRO A 234
None
0.84A 1fjaD-4g4iA:
undetectable
1fjaD-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN


(Homo sapiens)
PF00012
(HSP70)
3 THR A  64
THR A  66
PRO A  63
None
0.88A 1fjaD-4hwiA:
undetectable
1fjaD-4hwiA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jru THAUMATIN-LIKE
PROTEIN


(Vitis vinifera)
PF00314
(Thaumatin)
3 THR A  86
THR A 100
PRO A 102
None
0.86A 1fjaD-4jruA:
undetectable
1fjaD-4jruA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
no annotation 3 THR B 262
THR B 260
PRO B 229
None
PLP  B 601 (-3.3A)
HEM  B 602 (-4.0A)
0.87A 1fjaD-4l27B:
undetectable
1fjaD-4l27B:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN


(Calotropis
procera)
PF00314
(Thaumatin)
3 THR A 187
THR A 189
PRO A 186
None
0.77A 1fjaD-4l2jA:
undetectable
1fjaD-4l2jA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR


(Bacillus
subtilis)
PF00072
(Response_reg)
PF00196
(GerE)
3 THR A  35
THR A  61
PRO A  58
None
0.86A 1fjaD-4ldzA:
undetectable
1fjaD-4ldzA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N)
3 THR A 310
THR A 308
PRO A 306
None
0.83A 1fjaD-4lmpA:
undetectable
1fjaD-4lmpA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqd DNA-ENTRY NUCLEASE
INHIBITOR


(Bacillus
subtilis)
PF11033
(ComJ)
3 THR A 112
THR A 124
PRO A 114
None
0.79A 1fjaD-4mqdA:
undetectable
1fjaD-4mqdA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE


(Leptospira
biflexa)
PF00682
(HMGL-like)
3 THR A 178
THR A 208
PRO A 176
KIV  A 402 (-2.8A)
None
KIV  A 402 (-4.2A)
0.74A 1fjaD-4ov4A:
undetectable
1fjaD-4ov4A:
2.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A 257
THR A 259
PRO A 255
None
0.83A 1fjaD-4ovjA:
undetectable
1fjaD-4ovjA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry1 PERIPLASMIC SOLUTE
BINDING PROTEIN


(Pectobacterium
atrosepticum)
PF13416
(SBP_bac_8)
3 THR A 165
THR A 301
PRO A 303
None
0.88A 1fjaD-4ry1A:
undetectable
1fjaD-4ry1A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
3 THR A 162
THR A 166
PRO A 168
None
0.89A 1fjaD-4s3jA:
undetectable
1fjaD-4s3jA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3


(Rattus
norvegicus;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
3 THR A 229
THR A 231
PRO A 228
None
0.88A 1fjaD-4u16A:
undetectable
1fjaD-4u16A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
3 THR A 111
THR A 109
PRO A  75
None
PO4  A 401 (-4.1A)
None
0.88A 1fjaD-4u39A:
undetectable
1fjaD-4u39A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uu9 MEDI7814

(Homo sapiens)
PF07686
(V-set)
3 THR B  94
THR B  95
PRO B  93
None
0.78A 1fjaD-4uu9B:
undetectable
1fjaD-4uu9B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
3 THR A 303
THR A 305
PRO A 302
None
0.84A 1fjaD-4wzbA:
undetectable
1fjaD-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvh CARBOHYDRATE
ESTERASE FAMILY 2
(CE2)


(Chaetomium)
PF13472
(Lipase_GDSL_2)
3 THR A 288
THR A 285
PRO A 287
None
0.52A 1fjaD-4xvhA:
undetectable
1fjaD-4xvhA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ac9 VP1

(Foot-and-mouth
disease virus)
PF00073
(Rhv)
3 THR 1  68
THR 1  70
PRO 1 188
None
0.83A 1fjaD-5ac91:
undetectable
1fjaD-5ac91:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw8 UBIQUITIN-LIKE
PROTEIN MDY2


(Saccharomyces
cerevisiae)
PF16843
(Get5_bdg)
3 THR D  21
THR D  23
PRO D  25
None
0.85A 1fjaD-5bw8D:
undetectable
1fjaD-5bw8D:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum)
PF00026
(Asp)
3 THR A 114
THR A 116
PRO A 113
None
0.64A 1fjaD-5bwyA:
undetectable
1fjaD-5bwyA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
3 THR D1944
THR D1946
PRO D1943
None
0.68A 1fjaD-5disD:
undetectable
1fjaD-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis)
PF03415
(Peptidase_C11)
3 THR B 388
THR B 282
PRO B 278
None
0.85A 1fjaD-5dynB:
undetectable
1fjaD-5dynB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7o DMSO REDUCTASE
FAMILY TYPE II
ENZYME, IRON-SULFUR
SUBUNIT


(Azospira oryzae)
PF13247
(Fer4_11)
3 THR B 252
THR B 141
PRO B 254
SF4  B 403 ( 4.9A)
None
None
0.83A 1fjaD-5e7oB:
undetectable
1fjaD-5e7oB:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
3 THR A 393
THR A 390
PRO A 392
None
0.66A 1fjaD-5eodA:
undetectable
1fjaD-5eodA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris)
PF12783
(Sec7_N)
PF16213
(DCB)
3 THR A  66
THR A  64
PRO A  62
None
0.67A 1fjaD-5hasA:
undetectable
1fjaD-5hasA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs8 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YODB


(Bacillus
subtilis)
PF01638
(HxlR)
3 THR A  41
THR A  39
PRO A  43
None
0.79A 1fjaD-5hs8A:
undetectable
1fjaD-5hs8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ify GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Burkholderia
vietnamiensis)
PF00483
(NTP_transferase)
3 THR A  81
THR A  56
PRO A  83
None
0.88A 1fjaD-5ifyA:
undetectable
1fjaD-5ifyA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j78 ACETALDEHYDE
DEHYDROGENASE
(ACETYLATING)


(Parageobacillus
thermoglucosidasius)
PF00171
(Aldedh)
3 THR A 144
THR A 146
PRO A 143
ACT  A1005 (-3.3A)
None
ACT  A1005 (-3.9A)
0.75A 1fjaD-5j78A:
undetectable
1fjaD-5j78A:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 197
THR A 195
PRO A 200
1VU  A 601 ( 4.8A)
None
None
0.89A 1fjaD-5jfmA:
undetectable
1fjaD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE


(Rhodopseudomonas
palustris)
PF00171
(Aldedh)
3 THR A 201
THR A 203
PRO A 200
None
0.77A 1fjaD-5jfmA:
undetectable
1fjaD-5jfmA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1


(Oryctolagus
cuniculus)
PF00575
(S1)
PF07541
(EIF_2_alpha)
3 THR P 222
THR P 220
PRO P 224
None
0.87A 1fjaD-5k0yP:
undetectable
1fjaD-5k0yP:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum)
no annotation 3 THR A  75
THR A  77
PRO A 255
None
0.76A 1fjaD-5nmpA:
undetectable
1fjaD-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnb ISATIN HYDROLASE A

(Labrenzia
aggregata)
no annotation 3 THR A  70
THR A  72
PRO A 248
None
0.88A 1fjaD-5nnbA:
undetectable
1fjaD-5nnbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT
4,P52,GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4


(Homo sapiens)
no annotation 3 THR D 386
THR D 388
PRO D 385
None
0.83A 1fjaD-5of4D:
undetectable
1fjaD-5of4D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1


(Homo sapiens)
PF01485
(IBR)
3 THR B 129
THR B 131
PRO B 127
None
0.80A 1fjaD-5tteB:
undetectable
1fjaD-5tteB:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum)
no annotation 3 THR A   7
THR A   5
PRO A   8
THR  A   7 ( 0.8A)
THR  A   5 ( 0.8A)
PRO  A   8 ( 1.1A)
0.77A 1fjaD-5w0aA:
undetectable
1fjaD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
3 THR A 505
THR A 502
PRO A 504
None
0.67A 1fjaD-5w1uA:
undetectable
1fjaD-5w1uA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF00254
(FKBP_C)
3 THR A 184
THR A 133
PRO A 135
None
0.89A 1fjaD-5xb0A:
undetectable
1fjaD-5xb0A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE


(Hydrogenophilus
thermoluteolus)
PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S)
3 THR A 212
THR A 210
PRO A 209
None
0.88A 1fjaD-5xfaA:
undetectable
1fjaD-5xfaA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhv POLY [ADP-RIBOSE]
POLYMERASE 1


(Homo sapiens)
no annotation 3 THR A 821
THR A 973
PRO A 956
None
0.87A 1fjaD-6bhvA:
undetectable
1fjaD-6bhvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 3 THR A1074
THR A1076
PRO A1073
None
0.88A 1fjaD-6bq1A:
undetectable
1fjaD-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE


(Pseudomonas
putida)
no annotation 3 THR A 192
THR A 217
PRO A 193
None
0.83A 1fjaD-6dllA:
undetectable
1fjaD-6dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus)
no annotation 3 THR A1826
THR A1828
PRO A1820
None
0.84A 1fjaD-6fb3A:
undetectable
1fjaD-6fb3A:
undetectable