SIMILAR PATTERNS OF AMINO ACIDS FOR 1FIQ_C_SALC1335

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		4 LEU A 104
THR A 210
VAL A 209
ALA A  97
 None
 0.76A 1fiqC-1a59A:
0.0		 1fiqC-1a59A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN BETA 1)

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU B  75
VAL B 119
LEU B 122
ALA B 128
 None
 0.87A 1fiqC-1awcB:
0.0		 1fiqC-1awcB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		4 LEU A 372
ARG A 370
VAL A 380
LEU A 432
 None
 0.95A 1fiqC-1b3qA:
0.0		 1fiqC-1b3qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bi7 MULTIPLE TUMOR
SUPPRESSOR

(Homo sapiens) 		no annotation 4 LEU B  16
VAL B  59
LEU B  62
ALA B  68
 None
 0.93A 1fiqC-1bi7B:
undetectable		 1fiqC-1bi7B:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 LEU A 156
ARG A  31
LEU A 171
ALA A  35
 None
 0.83A 1fiqC-1bwdA:
undetectable		 1fiqC-1bwdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 LEU B 200
PHE B  13
VAL B  20
LEU B  21
 None
 0.77A 1fiqC-1ccwB:
0.0		 1fiqC-1ccwB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		4 LEU A 372
VAL A 386
LEU A 420
ALA A 416
 None
 0.83A 1fiqC-1d8cA:
0.0		 1fiqC-1d8cA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 LEU A  18
PHE A  45
VAL A  24
LEU A  37
ALA A  42
 None
 1.03A 1fiqC-1dj2A:
0.0		 1fiqC-1dj2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		5 LEU A  17
PHE A  44
VAL A  23
LEU A  36
ALA A  41
 None
 1.02A 1fiqC-1dj3A:
0.0		 1fiqC-1dj3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egj CYTOKINE RECEPTOR
COMMON BETA CHAIN
PRECURSOR

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A 402
VAL A 347
LEU A 356
ALA A 398
 None
 0.90A 1fiqC-1egjA:
0.0		 1fiqC-1egjA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 LEU E1253
VAL E1243
LEU E1240
ALA E1233
 None
 0.92A 1fiqC-1f51E:
undetectable		 1fiqC-1f51E:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		5 LEU A 366
PHE A  29
VAL A  89
LEU A  91
ALA A  31
 None
 1.46A 1fiqC-1f6dA:
undetectable		 1fiqC-1f6dA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF13374
(TPR_10)
PF13432
(TPR_16) 		4 LEU A 595
VAL A 539
LEU A 570
ALA A 545
 None
 0.92A 1fiqC-1fchA:
undetectable		 1fiqC-1fchA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		4 LEU A 150
VAL A 132
LEU A 160
ALA A 187
 None
 0.94A 1fiqC-1fhuA:
undetectable		 1fiqC-1fhuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		4 LEU A  11
VAL A 454
LEU A 455
ALA A 461
 None
 0.89A 1fiqC-1fp9A:
undetectable		 1fiqC-1fp9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A 464
VAL A 467
LEU A 471
ALA A 513
 None
 0.86A 1fiqC-1fprA:
undetectable		 1fiqC-1fprA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 LEU A 217
VAL A 472
LEU A 423
ALA A 416
 None
 0.94A 1fiqC-1hc7A:
undetectable		 1fiqC-1hc7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II

(Bacteroides
fragilis) 		no annotation 4 LEU A  80
THR A  85
LEU A  88
ALA A  65
 None
 0.83A 1fiqC-1hlkA:
2.4		 1fiqC-1hlkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 317
THR A 337
VAL A 338
ALA A 329
 None
 0.87A 1fiqC-1idmA:
1.0		 1fiqC-1idmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 291
THR A 243
VAL A 242
ALA A 276
 None
 0.93A 1fiqC-1iwaA:
undetectable		 1fiqC-1iwaA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		4 LEU C  28
THR C 140
LEU C  41
ALA C  55
 None
 0.91A 1fiqC-1ixrC:
undetectable		 1fiqC-1ixrC:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixs HOLLIDAY JUNCTION
DNA HELICASE RUVA

(Thermus
thermophilus) 		PF07499
(RuvA_C) 		4 LEU A 153
VAL A 166
LEU A 170
ALA A 146
 None
 0.82A 1fiqC-1ixsA:
undetectable		 1fiqC-1ixsA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3m THE CONSERVED
HYPOTHETICAL PROTEIN
TT1751

(Thermus
thermophilus) 		PF03625
(DUF302) 		4 LEU A  82
THR A   7
LEU A 129
ALA A  10
 None
 0.82A 1fiqC-1j3mA:
undetectable		 1fiqC-1j3mA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU A 131
VAL A 179
LEU A 182
ALA A 188
 None
 0.86A 1fiqC-1k1bA:
undetectable		 1fiqC-1k1bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 LEU A 441
THR A 326
LEU A 328
ALA A 414
 None
 0.83A 1fiqC-1la2A:
undetectable		 1fiqC-1la2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 LEU A 321
PHE A 208
VAL A 241
LEU A 163
 None
 0.90A 1fiqC-1lnzA:
undetectable		 1fiqC-1lnzA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		4 LEU A 137
VAL A 199
LEU A 195
ALA A 175
 None
 0.87A 1fiqC-1m3uA:
undetectable		 1fiqC-1m3uA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0r 4 ANKYRIN REPEATS

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU A  39
VAL A  83
LEU A  86
ALA A  92
 None
 0.81A 1fiqC-1n0rA:
undetectable		 1fiqC-1n0rA:
10.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
LEU A 873
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.30A 1fiqC-1n5xA:
64.9		 1fiqC-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		4 LEU A 896
VAL A 850
LEU A 846
ALA A 912
 None
 0.87A 1fiqC-1nd7A:
undetectable		 1fiqC-1nd7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6x PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF02244
(Propep_M14) 		4 LEU A  26
PHE A  39
VAL A  54
LEU A  13
 None
 0.93A 1fiqC-1o6xA:
undetectable		 1fiqC-1o6xA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 ARG A 171
VAL A  62
LEU A  66
ALA A 162
 None
 0.90A 1fiqC-1oa1A:
undetectable		 1fiqC-1oa1A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		4 LEU B  71
THR B  84
LEU B  88
ALA B 140
 None
None
HEM  B 148 (-4.6A)
None
 0.85A 1fiqC-1ouuB:
undetectable		 1fiqC-1ouuB:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 LEU A 241
VAL A 164
LEU A  53
ALA A 171
 None
 0.82A 1fiqC-1q1rA:
undetectable		 1fiqC-1q1rA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A 165
PHE A  52
THR A  65
VAL A  66
ALA A  60
 None
None
None
None
CAA  A 501 ( 3.7A)
 1.39A 1fiqC-1q51A:
undetectable		 1fiqC-1q51A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 LEU A 113
ARG A 107
VAL A 116
ALA A 103
 None
 0.92A 1fiqC-1qjcA:
undetectable		 1fiqC-1qjcA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		4 LEU A  20
PHE A 181
VAL A 191
LEU A 174
 None
 0.95A 1fiqC-1qyrA:
undetectable		 1fiqC-1qyrA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 LEU C   5
THR C  31
VAL C  32
LEU C  28
 None
 0.87A 1fiqC-1sb3C:
undetectable		 1fiqC-1sb3C:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		4 LEU A  86
PHE A  74
LEU A  15
ALA A  17
 None
 0.96A 1fiqC-1tc5A:
undetectable		 1fiqC-1tc5A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		4 LEU A 145
PHE A 162
LEU A 129
ALA A 165
 None
 0.76A 1fiqC-1td6A:
undetectable		 1fiqC-1td6A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uit HUMAN DISCS LARGE 5
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A  32
VAL A  46
LEU A  66
ALA A  82
 None
 0.88A 1fiqC-1uitA:
undetectable		 1fiqC-1uitA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		4 LEU A  53
THR A  16
VAL A  15
LEU A  89
 None
None
XE  A1118 (-4.5A)
None
 0.93A 1fiqC-1uvyA:
undetectable		 1fiqC-1uvyA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		4 LEU A  85
VAL A  12
LEU A   6
ALA A  92
 None
XE  A1118 ( 3.9A)
None
None
 0.85A 1fiqC-1uvyA:
undetectable		 1fiqC-1uvyA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 LEU A  68
VAL A 102
LEU A 106
ALA A  28
 None
 0.87A 1fiqC-1vfnA:
undetectable		 1fiqC-1vfnA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		4 LEU A 142
VAL A 181
LEU A 177
ALA A 165
 None
 0.95A 1fiqC-1wg8A:
undetectable		 1fiqC-1wg8A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 LEU A 154
VAL A 113
LEU A 108
ALA A 202
 None
 0.89A 1fiqC-1x2gA:
undetectable		 1fiqC-1x2gA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE

(Acidaminococcus
fermentans) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 109
THR A 203
VAL A 231
ALA A 234
 None
 0.93A 1fiqC-1xdwA:
1.4		 1fiqC-1xdwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Vibrio cholerae) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 298
VAL A 164
LEU A 200
ALA A 213
 None
 0.94A 1fiqC-1xeaA:
undetectable		 1fiqC-1xeaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 LEU A  28
VAL A  55
LEU A 524
ALA A  62
 None
 0.87A 1fiqC-1xl8A:
undetectable		 1fiqC-1xl8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 LEU A 223
ARG A 227
VAL A  29
LEU A  36
 None
 0.79A 1fiqC-1xs5A:
undetectable		 1fiqC-1xs5A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 LEU A 104
THR A  94
VAL A  91
ALA A  48
 None
 0.80A 1fiqC-1yxmA:
undetectable		 1fiqC-1yxmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxx 6-PHOSPHOFRUCTOKINAS
E

(Lactobacillus
delbrueckii) 		PF00365
(PFK) 		4 LEU A 275
VAL A 284
LEU A 122
ALA A 109
 None
 0.90A 1fiqC-1zxxA:
1.5		 1fiqC-1zxxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL

(Homo sapiens) 		PF02817
(E3_binding)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 443
VAL K 167
LEU K 164
ALA K 135
 None
 0.94A 1fiqC-1zy8A:
undetectable		 1fiqC-1zy8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum) 		PF12150
(MFP2b) 		4 LEU A 275
VAL A 211
LEU A 272
ALA A 196
 None
 0.93A 1fiqC-2bjrA:
undetectable		 1fiqC-2bjrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF00515
(TPR_1)
PF13432
(TPR_16) 		4 LEU A 632
VAL A 576
LEU A 607
ALA A 582
 None
 0.93A 1fiqC-2c0lA:
undetectable		 1fiqC-2c0lA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c27 MYCOTHIOL SYNTHASE

(Mycobacterium
tuberculosis) 		PF00583
(Acetyltransf_1) 		4 LEU A 297
VAL A 235
LEU A 238
ALA A 290
 None
None
COA  A1314 (-4.5A)
COA  A1314 (-3.6A)
 0.95A 1fiqC-2c27A:
undetectable		 1fiqC-2c27A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dck XYLANASE J

(Bacillus sp.
41M-1) 		PF00457
(Glyco_hydro_11)
PF03422
(CBM_6) 		4 LEU A 258
PHE A 284
LEU A 236
ALA A 268
 None
 0.86A 1fiqC-2dckA:
undetectable		 1fiqC-2dckA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 LEU A 819
VAL A 288
LEU A 578
ALA A 294
 None
FAD  A1001 (-4.9A)
None
None
 0.70A 1fiqC-2dw4A:
undetectable		 1fiqC-2dw4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		5 LEU A 386
THR A 324
VAL A 323
LEU A 339
ALA A 382
 None
 1.14A 1fiqC-2eceA:
undetectable		 1fiqC-2eceA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A 253
VAL A 227
LEU A 233
ALA A 260
 None
 0.72A 1fiqC-2eezA:
undetectable		 1fiqC-2eezA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flh CYTOKININ-SPECIFIC
BINDING PROTEIN

(Vigna radiata) 		PF00407
(Bet_v_1) 		4 LEU A 146
ARG A 144
THR A   9
VAL A 114
 None
 0.90A 1fiqC-2flhA:
undetectable		 1fiqC-2flhA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 296
ARG A 305
PHE A 111
THR A  61
VAL A 271
 None
MLR  A2913 (-3.0A)
None
None
None
 1.31A 1fiqC-2gh9A:
undetectable		 1fiqC-2gh9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2

(Rotavirus C) 		PF02509
(Rota_NS35) 		4 LEU A  79
VAL A   8
LEU A   4
ALA A   2
 None
 0.87A 1fiqC-2gu0A:
undetectable		 1fiqC-2gu0A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
delbrueckii) 		PF13419
(HAD_2) 		4 LEU A  59
PHE A  29
LEU A  93
ALA A  28
 None
 0.85A 1fiqC-2hi0A:
undetectable		 1fiqC-2hi0A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.94A 1fiqC-2iyfA:
undetectable		 1fiqC-2iyfA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		4 LEU A  88
THR A  78
VAL A  75
ALA A  37
 None
 0.89A 1fiqC-2jahA:
undetectable		 1fiqC-2jahA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922

(Mycobacterium
tuberculosis) 		PF00691
(OmpA)
PF04972
(BON) 		4 LEU A 153
PHE A 142
LEU A 133
ALA A 138
 None
 0.92A 1fiqC-2l26A:
undetectable		 1fiqC-2l26A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lst THIOREDOXIN

(Thermus
thermophilus) 		PF13899
(Thioredoxin_7) 		4 LEU A  70
VAL A  83
LEU A  85
ALA A  11
 None
 0.93A 1fiqC-2lstA:
undetectable		 1fiqC-2lstA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lst THIOREDOXIN

(Thermus
thermophilus) 		PF13899
(Thioredoxin_7) 		4 LEU A  70
VAL A  83
LEU A  85
ALA A  58
 None
 0.90A 1fiqC-2lstA:
undetectable		 1fiqC-2lstA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpf POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Homo sapiens) 		PF00027
(cNMP_binding) 		4 LEU A 642
PHE A 552
LEU A 544
ALA A 548
 None
 0.83A 1fiqC-2mpfA:
undetectable		 1fiqC-2mpfA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		4 THR A  40
VAL A  41
LEU A  38
ALA A  35
 None
 0.95A 1fiqC-2n57A:
undetectable		 1fiqC-2n57A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		5 LEU A  88
PHE A  77
VAL A  65
LEU A  35
ALA A  75
 None
 1.42A 1fiqC-2p0oA:
undetectable		 1fiqC-2p0oA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		4 LEU A 251
PHE A  98
VAL A 102
LEU A  93
 None
 0.93A 1fiqC-2pb0A:
undetectable		 1fiqC-2pb0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 LEU B 268
PHE B 235
VAL B 274
LEU B 265
 None
 0.92A 1fiqC-2pbiB:
undetectable		 1fiqC-2pbiB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peg HEMOGLOBIN SUBUNIT
BETA

(Trematomus
bernacchii) 		PF00042
(Globin) 		4 LEU B  71
THR B  84
LEU B  88
ALA B 140
 None
None
HEM  B 400 ( 4.8A)
None
 0.90A 1fiqC-2pegB:
undetectable		 1fiqC-2pegB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis) 		PF00378
(ECH_1) 		4 LEU A  82
VAL A 128
LEU A 129
ALA A 413
 None
 0.83A 1fiqC-2pg8A:
undetectable		 1fiqC-2pg8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prf PROFILIN IA

(Acanthamoeba
sp.) 		PF00235
(Profilin) 		5 LEU A  62
PHE A  60
THR A  88
VAL A  97
LEU A  22
 None
 1.37A 1fiqC-2prfA:
undetectable		 1fiqC-2prfA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pts ADENYLOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 LEU A 135
VAL A 261
LEU A 321
ALA A 325
 None
 0.90A 1fiqC-2ptsA:
undetectable		 1fiqC-2ptsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 LEU A 161
VAL A  99
LEU A  92
ALA A 150
 None
 0.93A 1fiqC-2qmiA:
undetectable		 1fiqC-2qmiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
BETA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		4 LEU B  71
THR B  84
LEU B  88
ALA B 141
 None
None
HEM  B 148 ( 4.6A)
None
 0.87A 1fiqC-2r1hB:
undetectable		 1fiqC-2r1hB:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.) 		PF00502
(Phycobilisome) 		4 LEU A  51
THR A  96
VAL A  95
ALA A  40
 None
 0.92A 1fiqC-2uunA:
undetectable		 1fiqC-2uunA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 LEU A 152
PHE A  88
VAL A  44
LEU A  32
 None
 0.88A 1fiqC-2vreA:
undetectable		 1fiqC-2vreA:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 303
ARG B 310
PHE B 344
LEU B 461
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
None
 0.87A 1fiqC-2w55B:
53.6		 1fiqC-2w55B:
40.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.35A 1fiqC-2w55B:
53.6		 1fiqC-2w55B:
40.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		4 LEU A  71
ARG A  52
THR A  29
ALA A  62
 None
 0.90A 1fiqC-2wk1A:
undetectable		 1fiqC-2wk1A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		4 LEU A  11
VAL A 454
LEU A 455
ALA A 461
 None
 0.83A 1fiqC-2x1iA:
undetectable		 1fiqC-2x1iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.37A 1fiqC-2x8xX:
undetectable		 1fiqC-2x8xX:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 LEU A 420
THR A 452
LEU A 456
ALA A 413
 None
 0.94A 1fiqC-2xqyA:
1.7		 1fiqC-2xqyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A

(Mycobacterium
tuberculosis) 		PF00977
(His_biosynth) 		4 LEU A 229
ARG A 233
VAL A 203
LEU A 209
 None
 0.88A 1fiqC-2y89A:
undetectable		 1fiqC-2y89A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		4 LEU A 208
VAL A 142
LEU A 202
ALA A 168
 None
 0.84A 1fiqC-2yjpA:
undetectable		 1fiqC-2yjpA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 409
VAL A 405
LEU A 277
ALA A 279
 None
None
None
DMS  A 999 ( 4.6A)
 0.92A 1fiqC-2yneA:
0.4		 1fiqC-2yneA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv4 HYPOTHETICAL PROTEIN
PH0435

(Pyrococcus
horikoshii) 		PF03481
(SUA5) 		4 LEU A 329
VAL A 292
LEU A 285
ALA A 299
 None
 0.69A 1fiqC-2yv4A:
undetectable		 1fiqC-2yv4A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 178
ARG A 267
VAL A 338
ALA A 333
 None
 0.91A 1fiqC-2z01A:
undetectable		 1fiqC-2z01A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT

(Aquifex
aeolicus) 		PF02222
(ATP-grasp) 		4 LEU A 224
PHE A 234
VAL A  89
ALA A 252
 None
 0.91A 1fiqC-2z04A:
undetectable		 1fiqC-2z04A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 LEU A 681
VAL A 654
LEU A 651
ALA A 694
 None
 0.88A 1fiqC-2zj8A:
undetectable		 1fiqC-2zj8A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		5 LEU A 388
ARG A 384
THR A 382
LEU A 371
ALA A 348
 None
GOL  A 915 ( 4.6A)
GOL  A 917 (-4.1A)
None
GOL  A 915 (-3.4A)
 1.44A 1fiqC-3a21A:
undetectable		 1fiqC-3a21A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 LEU A 193
THR A 150
VAL A 153
ALA A 226
 None
 0.90A 1fiqC-3a6pA:
undetectable		 1fiqC-3a6pA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		4 LEU A 271
ARG A 207
PHE A 206
ALA A 197
 None
 0.85A 1fiqC-3atyA:
0.0		 1fiqC-3atyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF00551
(Formyl_trans_N) 		4 THR A 180
VAL A 181
LEU A 182
ALA A  21
 None
 0.87A 1fiqC-3av3A:
undetectable		 1fiqC-3av3A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 LEU A1267
PHE A1158
VAL A1582
LEU A1586
 None
None
SAM  A   1 (-3.8A)
None
 0.95A 1fiqC-3av6A:
undetectable		 1fiqC-3av6A:
20.25