SIMILAR PATTERNS OF AMINO ACIDS FOR 1FFY_A_MRCA1993_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b4t | PROTEIN (CU/ZNSUPEROXIDEDISMUTASE) (Saccharomycescerevisiae) |
PF00080(Sod_Cu) | 5 | PRO A 142GLY A 85GLY A 138ASP A 125HIS A 71 | NoneNoneNoneNone ZN A 155 ( 3.2A) | 1.25A | 1ffyA-1b4tA:undetectable | 1ffyA-1b4tA:9.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5f | METHIONINEGAMMA-LYASE (Trichomonasvaginalis) |
PF01053(Cys_Met_Meta_PP) | 5 | GLY A 49ASN A 45GLY A 44PHE A 47MET A 234 | None | 1.29A | 1ffyA-1e5fA:undetectable | 1ffyA-1e5fA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gso | PROTEIN (GLYCINAMIDERIBONUCLEOTIDESYNTHETASE) (Escherichiacoli) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | GLY A 368ASN A 34GLY A 10ASP A 293VAL A 384 | None | 1.06A | 1ffyA-1gsoA:undetectable | 1ffyA-1gsoA:18.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ile | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 6 | HIS A 57GLY A 56SER A 521GLY A 551GLN A 554HIS A 581 | None | 1.21A | 1ffyA-1ileA:32.9 | 1ffyA-1ileA:30.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ile | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 8 | PRO A 46GLY A 56SER A 521GLY A 551ASP A 553GLN A 554HIS A 581MET A 592 | None | 0.86A | 1ffyA-1ileA:32.9 | 1ffyA-1ileA:30.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ile | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 8 | PRO A 46HIS A 54GLY A 56SER A 521GLY A 551GLN A 554HIS A 581MET A 592 | None | 0.73A | 1ffyA-1ileA:32.9 | 1ffyA-1ileA:30.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1li7 | CYSTEINYL-TRNASYNTHETASE (Escherichiacoli) |
PF01406(tRNA-synt_1e)PF09190(DALR_2) | 5 | HIS A 37GLY A 39GLY A 227ASP A 229VAL A 260 | None | 0.57A | 1ffyA-1li7A:20.5 | 1ffyA-1li7A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nb2 | NUCLEOSIDEDIPHOSPHATE KINASE (Virgibacillushalodenitrificans) |
PF00334(NDK) | 5 | PRO A 11GLY A 107ASN A 113SER A 68GLY A 111 | None | 1.12A | 1ffyA-1nb2A:undetectable | 1ffyA-1nb2A:9.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q50 | GLUCOSE-6-PHOSPHATEISOMERASE (Leishmaniamexicana) |
PF00342(PGI) | 5 | HIS A 238ASN A 268GLY A 203ASP A 208VAL A 200 | None | 1.29A | 1ffyA-1q50A:undetectable | 1ffyA-1q50A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qh5 | PROTEIN(HYDROXYACYLGLUTATHIONE HYDROLASE) (Homo sapiens) |
PF00753(Lactamase_B)PF16123(HAGH_C) | 5 | PRO A 30GLY A 133ASP A 134PHE A 137VAL A 138 | NoneNone ZN A 262 ( 2.4A)GSH A 463 (-4.9A)None | 1.03A | 1ffyA-1qh5A:undetectable | 1ffyA-1qh5A:14.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 6 | HIS A 67GLY A 66GLY A 555ASP A 557GLN A 558HIS A 585 | MRC A1993 (-4.1A)MRC A1993 ( 3.7A)MRC A1993 (-3.8A)MRC A1993 (-3.2A)MRC A1993 (-3.5A)MRC A1993 (-4.5A) | 1.13A | 1ffyA-1qu2A:62.3 | 1ffyA-1qu2A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 6 | HIS A 67SER A 565GLY A 555ASP A 557GLN A 558HIS A 585 | MRC A1993 (-4.1A)NoneMRC A1993 (-3.8A)MRC A1993 (-3.2A)MRC A1993 (-3.5A)MRC A1993 (-4.5A) | 1.25A | 1ffyA-1qu2A:62.3 | 1ffyA-1qu2A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 6 | HIS A 67SER A 566GLY A 555ASP A 557GLN A 558HIS A 585 | MRC A1993 (-4.1A)NoneMRC A1993 (-3.8A)MRC A1993 (-3.2A)MRC A1993 (-3.5A)MRC A1993 (-4.5A) | 1.27A | 1ffyA-1qu2A:62.3 | 1ffyA-1qu2A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 12 | PRO A 56HIS A 64GLY A 66ASN A 70SER A 531GLY A 555ASP A 557GLN A 558HIS A 585PHE A 587VAL A 588MET A 596 | MRC A1993 (-3.4A)MRC A1993 (-4.1A)MRC A1993 ( 3.7A)MRC A1993 ( 4.2A)MRC A1993 ( 4.0A)MRC A1993 (-3.8A)MRC A1993 (-3.2A)MRC A1993 (-3.5A)MRC A1993 (-4.5A)MRC A1993 (-3.5A)MRC A1993 (-3.9A)None | 0.07A | 1ffyA-1qu2A:62.3 | 1ffyA-1qu2A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qu2 | ISOLEUCYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00133(tRNA-synt_1)PF06827(zf-FPG_IleRS)PF08264(Anticodon_1) | 6 | PRO A 57GLY A 555ASP A 557GLN A 558HIS A 585PHE A 587 | MRC A1993 ( 4.7A)MRC A1993 (-3.8A)MRC A1993 (-3.2A)MRC A1993 (-3.5A)MRC A1993 (-4.5A)MRC A1993 (-3.5A) | 1.29A | 1ffyA-1qu2A:62.3 | 1ffyA-1qu2A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkz | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Thermotogamaritima) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | GLY A 348ASN A 35GLY A 13ASP A 280VAL A 363 | None | 1.22A | 1ffyA-1vkzA:undetectable | 1ffyA-1vkzA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkb | LEUCYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 5 | HIS A 53SER A 532GLY A 610ASP A 612MET A 651 | None | 0.99A | 1ffyA-1wkbA:25.1 | 1ffyA-1wkbA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wz2 | LEUCYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 5 | HIS A 53SER A 532GLY A 610ASP A 612MET A 651 | None | 1.07A | 1ffyA-1wz2A:25.9 | 1ffyA-1wz2A:25.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ydn | HYDROXYMETHYLGLUTARYL-COA LYASE (Brucellamelitensis) |
PF00682(HMGL-like) | 5 | PRO A 239GLY A 234GLY A 15ASP A 14VAL A 232 | NoneNoneNone CA A 601 (-2.7A)None | 1.25A | 1ffyA-1ydnA:undetectable | 1ffyA-1ydnA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5m | DAMAGE-SPECIFIC DNABINDING PROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | ASN A 211GLY A 187ASP A 184GLN A 186VAL A 181 | None | 1.12A | 1ffyA-2b5mA:undetectable | 1ffyA-2b5mA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ct8 | METHIONYL-TRNASYNTHETASE (Aquifexaeolicus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF09334(tRNA-synt_1g) | 5 | HIS A 21GLY A 23GLY A 257ASP A 259HIS A 286 | MSP A 501 (-4.6A)MSP A 501 (-3.6A)MSP A 501 (-2.9A)MSP A 501 (-3.0A)MSP A 501 (-4.4A) | 0.79A | 1ffyA-2ct8A:25.0 | 1ffyA-2ct8A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ct8 | METHIONYL-TRNASYNTHETASE (Aquifexaeolicus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF09334(tRNA-synt_1g) | 5 | HIS A 24GLY A 23GLY A 257ASP A 259HIS A 286 | MSP A 501 (-4.2A)MSP A 501 (-3.6A)MSP A 501 (-2.9A)MSP A 501 (-3.0A)MSP A 501 (-4.4A) | 1.19A | 1ffyA-2ct8A:25.0 | 1ffyA-2ct8A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cyc | TYROSYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00579(tRNA-synt_1b) | 6 | HIS A 47GLY A 49GLY A 187ASP A 189GLN A 190HIS A 223 | NoneNoneNoneNoneTYR A 701 (-3.3A)None | 0.66A | 1ffyA-2cycA:4.6 | 1ffyA-2cycA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 5 | PRO A 78GLY A 415ASN A 11GLY A 10ASP A 8 | NoneADP A1001 (-3.6A)ADP A1001 (-4.4A)ADP A1001 (-3.3A) MG A1003 ( 4.1A) | 1.04A | 1ffyA-2d0oA:undetectable | 1ffyA-2d0oA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dlc | TYROSYL-TRNASYNTHETASE,CYTOPLASMIC (Saccharomycescerevisiae) |
PF00579(tRNA-synt_1b) | 5 | HIS X 53GLY X 189ASP X 191GLN X 192VAL X 219 | YMP X 601 (-4.3A)YMP X 601 (-2.8A)YMP X 601 (-3.2A)YMP X 601 (-3.4A)YMP X 601 (-3.8A) | 0.85A | 1ffyA-2dlcX:7.5 | 1ffyA-2dlcX:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h84 | STEELY1 (Dictyosteliumdiscoideum) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | PRO A2869GLY A2982PHE A3112VAL A3110MET A3114 | None | 1.28A | 1ffyA-2h84A:undetectable | 1ffyA-2h84A:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfi | CHLORIDE CHANNELPROTEIN CLC-KA (Homo sapiens) |
PF00571(CBS) | 5 | GLY A 666ASN A 552SER A 573PHE A 657VAL A 658 | None | 1.22A | 1ffyA-2pfiA:undetectable | 1ffyA-2pfiA:11.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyw | UNCHARACTERIZEDPROTEIN (Arabidopsisthaliana) |
PF01636(APH) | 5 | PRO A 67ASN A 48GLN A 64PHE A 51VAL A 42 | NoneADP A 999 (-3.9A)NoneNoneNone | 1.22A | 1ffyA-2pywA:undetectable | 1ffyA-2pywA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qf7 | PYRUVATE CARBOXYLASEPROTEIN (Rhizobium etli) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | GLY A 622ASN A 662SER A 920PHE A 654VAL A 653 | NoneNoneNoneKCX A 718 ( 4.2A)None | 1.02A | 1ffyA-2qf7A:undetectable | 1ffyA-2qf7A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qk4 | TRIFUNCTIONAL PURINEBIOSYNTHETIC PROTEINADENOSINE-3 (Homo sapiens) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | GLY A 371ASN A 36GLY A 12ASP A 295VAL A 386 | None | 1.18A | 1ffyA-2qk4A:undetectable | 1ffyA-2qk4A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqp | LARGE CAPSID PROTEIN (Providencevirus) |
PF03566(Peptidase_A21) | 6 | GLY A 309ASN A 328GLY A 327ASP A 326GLN A 284VAL A 332 | None | 1.38A | 1ffyA-2qqpA:undetectable | 1ffyA-2qqpA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x1m | METHIONYL-TRNASYNTHETASE (Mycolicibacteriumsmegmatis) |
PF09334(tRNA-synt_1g) | 5 | HIS A 22GLY A 21GLY A 263ASP A 265HIS A 292 | None | 1.23A | 1ffyA-2x1mA:22.7 | 1ffyA-2x1mA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ys6 | PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE (Geobacilluskaustophilus) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | GLY A 362ASN A 34GLY A 10ASP A 290VAL A 377 | None | 1.29A | 1ffyA-2ys6A:undetectable | 1ffyA-2ys6A:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yw2 | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Aquifexaeolicus) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | GLY A 364ASN A 34GLY A 10ASP A 290VAL A 379 | None | 1.23A | 1ffyA-2yw2A:undetectable | 1ffyA-2yw2A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yy5 | TRYPTOPHANYL-TRNASYNTHETASE (Mycoplasmapneumoniae) |
PF00579(tRNA-synt_1b) | 5 | HIS A 16GLY A 18GLY A 152ASP A 154GLN A 155 | SO4 A1362 ( 4.1A)WSA A1350 (-3.5A)WSA A1350 (-3.2A)WSA A1350 (-2.7A)SO4 A1363 ( 3.2A) | 0.69A | 1ffyA-2yy5A:5.8 | 1ffyA-2yy5A:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zua | NUCLEOSIDEDIPHOSPHATE KINASE (Haloarculaquadrata) |
PF00334(NDK) | 5 | PRO A 13GLY A 109ASN A 115SER A 70GLY A 113 | None | 1.25A | 1ffyA-2zuaA:undetectable | 1ffyA-2zuaA:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuf | ARGINYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 5 | HIS A 135GLY A 137ASN A 141GLY A 384VAL A 418 | None | 0.75A | 1ffyA-2zufA:13.7 | 1ffyA-2zufA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ag6 | PANTOTHENATESYNTHETASE (Staphylococcusaureus) |
PF02569(Pantoate_ligase) | 5 | HIS A 35GLY A 37GLY A 148ASP A 151VAL A 177 | PAJ A 501 (-4.3A)PAJ A 501 ( 4.1A)PAJ A 501 (-3.1A)PAJ A 501 (-3.8A)PAJ A 501 (-3.9A) | 0.94A | 1ffyA-3ag6A:2.2 | 1ffyA-3ag6A:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b54 | NUCLEOSIDEDIPHOSPHATE KINASE (Saccharomycescerevisiae) |
PF00334(NDK) | 5 | PRO A 14GLY A 110ASN A 116SER A 71GLY A 114 | NoneNonePO4 A 154 ( 4.3A)NoneNone | 1.13A | 1ffyA-3b54A:undetectable | 1ffyA-3b54A:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9c | METHIONYL-TRNASYNTHETASE (Escherichiacoli) |
PF09334(tRNA-synt_1g) | 5 | HIS A 21GLY A 23GLY A 294HIS A 323VAL A 326 | None | 0.83A | 1ffyA-3h9cA:22.5 | 1ffyA-3h9cA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hje | 704AA LONGHYPOTHETICALGLYCOSYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00128(Alpha-amylase)PF09196(DUF1953) | 5 | PRO A 575GLY A 265GLY A 268ASP A 270VAL A 248 | None | 1.13A | 1ffyA-3hjeA:undetectable | 1ffyA-3hjeA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icq | EXPORTIN-T (Schizosaccharomycespombe) |
PF08389(Xpo1) | 5 | PRO T 682GLY T 724ASN T 728SER T 626PHE T 721 | None | 1.20A | 1ffyA-3icqT:undetectable | 1ffyA-3icqT:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3inn | PANTOTHENATESYNTHETASE (Brucellamelitensis) |
PF02569(Pantoate_ligase) | 5 | HIS A 34GLY A 36GLY A 147ASP A 150VAL A 176 | ATP A 300 (-4.5A)ATP A 300 ( 4.1A)ATP A 300 (-3.4A)ATP A 300 (-3.6A)ATP A 300 (-4.0A) | 0.96A | 1ffyA-3innA:4.6 | 1ffyA-3innA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1u | BETA-XYLOSIDASE,FAMILY 43 GLYCOSYLHYDROLASE (Clostridiumacetobutylicum) |
PF04616(Glyco_hydro_43) | 5 | HIS A 277GLY A 259ASN A 261GLY A 197ASP A 135 | TRS A 801 (-4.5A)NoneNoneTRS A 801 ( 4.4A)TRS A 801 (-2.8A) | 1.23A | 1ffyA-3k1uA:undetectable | 1ffyA-3k1uA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfl | METHIONYL-TRNASYNTHETASE (Leishmaniamajor) |
PF09334(tRNA-synt_1g) | 5 | HIS A 225GLY A 227GLY A 484ASP A 486HIS A 513 | POP A 802 ( 4.0A)ME8 A 801 (-3.4A)ME8 A 801 (-3.2A)ME8 A 801 ( 2.6A)ME8 A 801 (-4.6A) | 0.80A | 1ffyA-3kflA:21.6 | 1ffyA-3kflA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfl | METHIONYL-TRNASYNTHETASE (Leishmaniamajor) |
PF09334(tRNA-synt_1g) | 5 | HIS A 228GLY A 227GLY A 484ASP A 486HIS A 513 | POP A 802 ( 3.8A)ME8 A 801 (-3.4A)ME8 A 801 (-3.2A)ME8 A 801 ( 2.6A)ME8 A 801 (-4.6A) | 1.05A | 1ffyA-3kflA:21.6 | 1ffyA-3kflA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kwe | CARBON DIOXIDECONCENTRATINGMECHANISM PROTEIN (Thermosynechococcuselongatus) |
PF00132(Hexapep) | 5 | HIS A 107GLY A 108ASN A 126GLY A 80VAL A 92 | ZN A 194 (-3.4A)NoneNoneNoneNone | 1.19A | 1ffyA-3kweA:undetectable | 1ffyA-3kweA:11.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lv4 | GLYCOSIDE HYDROLASEYXIA (Bacilluslicheniformis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 5 | HIS A 335GLY A 317ASN A 319GLY A 229ASP A 175 | NoneNoneNone CA A 501 ( 4.8A)None | 1.29A | 1ffyA-3lv4A:undetectable | 1ffyA-3lv4A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mjf | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Yersinia pestis) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | GLY A 368ASN A 34GLY A 10ASP A 293VAL A 384 | None | 1.17A | 1ffyA-3mjfA:undetectable | 1ffyA-3mjfA:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfe | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Legionellapneumophila) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | PRO A 415GLY A 192SER A 166ASP A 129MET A 452 | GOL A 520 ( 4.8A) ZN A 504 ( 3.9A)None ZN A 502 ( 2.3A)None | 1.08A | 1ffyA-3pfeA:undetectable | 1ffyA-3pfeA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q10 | PANTOATE--BETA-ALANINE LIGASE (Yersinia pestis) |
PF02569(Pantoate_ligase) | 5 | HIS A 34GLY A 36GLY A 149ASP A 152VAL A 178 | AMP A 501 (-4.4A)AMP A 501 ( 3.9A)AMP A 501 (-3.3A)AMP A 501 (-3.6A)AMP A 501 (-4.0A) | 0.92A | 1ffyA-3q10A:2.3 | 1ffyA-3q10A:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q87 | N6 ADENINE SPECIFICDNA METHYLASE (Encephalitozooncuniculi) |
PF05175(MTS) | 5 | PRO B 6ASN B 85GLY B 31ASP B 51VAL B 106 | SAM B 300 ( 4.5A)SAM B 300 (-3.9A)SAM B 300 (-3.5A)SAM B 300 (-2.9A)None | 1.29A | 1ffyA-3q87B:undetectable | 1ffyA-3q87B:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q8y | NUCLEOSIDEDIPHOSPHATE KINASE (Staphylococcusaureus) |
PF00334(NDK) | 5 | PRO A 10GLY A 106ASN A 112SER A 67GLY A 110 | NoneNoneADP A 158 (-2.2A)NoneADP A 158 (-3.5A) | 1.19A | 1ffyA-3q8yA:undetectable | 1ffyA-3q8yA:10.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2u | METALLO-BETA-LACTAMASE FAMILY PROTEIN (Staphylococcusaureus) |
PF00753(Lactamase_B) | 6 | PRO A 31SER A 63GLY A 144ASP A 145PHE A 148VAL A 149 | NoneNoneNone FE A 443 (-3.2A)NoneNone | 1.24A | 1ffyA-3r2uA:undetectable | 1ffyA-3r2uA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5g | CYAB (Pseudomonasaeruginosa) |
PF00211(Guanylate_cyc) | 5 | GLY A 270GLY A 285ASP A 286PHE A 283VAL A 282 | None | 1.11A | 1ffyA-3r5gA:undetectable | 1ffyA-3r5gA:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjt | LIPOLYTIC PROTEING-D-S-L FAMILY (Alicyclobacillusacidocaldarius) |
PF13472(Lipase_GDSL_2) | 5 | HIS A 199GLY A 35ASN A 34GLY A 19VAL A 37 | CSO A 18 ( 4.2A)CSO A 18 ( 3.8A)NoneCSO A 18 ( 2.4A)None | 1.26A | 1ffyA-3rjtA:undetectable | 1ffyA-3rjtA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tp9 | BETA-LACTAMASE ANDRHODANESE DOMAINPROTEIN (Alicyclobacillusacidocaldarius) |
PF00581(Rhodanese)PF00753(Lactamase_B) | 6 | PRO A 31SER A 63GLY A 145ASP A 146PHE A 149VAL A 150 | NoneNoneNone ZN A 472 (-3.1A)NoneNone | 1.19A | 1ffyA-3tp9A:undetectable | 1ffyA-3tp9A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk2 | PANTOTHENATESYNTHETASE (Burkholderiathailandensis) |
PF02569(Pantoate_ligase) | 5 | HIS A 30GLY A 32GLY A 144ASP A 147VAL A 173 | AMP A 280 (-4.7A)AMP A 280 ( 3.9A)AMP A 280 (-3.3A)MLT A 284 ( 3.5A)AMP A 280 (-3.9A) | 0.93A | 1ffyA-3uk2A:2.5 | 1ffyA-3uk2A:14.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgj | TYROSYL-TRNASYNTHETASE, PUTATIVE (Plasmodiumfalciparum) |
PF00579(tRNA-synt_1b) | 5 | HIS A 70GLY A 207ASP A 209GLN A 210HIS A 235 | AMP A 402 (-4.4A)AMP A 402 (-3.1A)AMP A 402 (-2.8A)TYR A 401 ( 3.3A)AMP A 402 (-4.0A) | 0.56A | 1ffyA-3vgjA:undetectable | 1ffyA-3vgjA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjs | NADH OXIDASE (Gluconobacteroxydans) |
PF00724(Oxidored_FMN) | 5 | GLY A 267ASN A 266SER A 278GLY A 264GLN A 293 | None | 1.24A | 1ffyA-3wjsA:undetectable | 1ffyA-3wjsA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arc | LEUCINE--TRNA LIGASE (Escherichiacoli) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2) | 6 | GLY A 51ASN A 55SER A 496GLY A 530VAL A 569MET A 620 | NoneNoneLEU A1001 ( 3.7A)NoneNoneNone | 0.80A | 1ffyA-4arcA:27.6 | 1ffyA-4arcA:27.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bqm | GLUTAMINASE LIVERISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase) | 5 | PRO A 223HIS A 239GLY A 243ASN A 264GLY A 270 | NoneNoneNoneEDO A1467 (-3.5A)None | 1.15A | 1ffyA-4bqmA:undetectable | 1ffyA-4bqmA:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dve | BIOTIN TRANSPORTERBIOY (Lactococcuslactis) |
PF02632(BioY) | 5 | PRO A 35ASN A 156GLY A 137VAL A 130MET A 46 | None | 1.06A | 1ffyA-4dveA:undetectable | 1ffyA-4dveA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2t | SSFS6 (Streptomycessp. SF2575) |
PF00201(UDPGT)PF06722(DUF1205) | 5 | PRO A 278HIS A 292GLY A 294GLY A 12VAL A 317 | TYD A 401 (-4.2A)TYD A 401 (-3.9A)TYD A 401 (-3.5A)TYD A 401 ( 3.7A)None | 1.22A | 1ffyA-4g2tA:2.0 | 1ffyA-4g2tA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g6z | GLUTAMATE-TRNALIGASE (Burkholderiathailandensis) |
PF00749(tRNA-synt_1c) | 5 | HIS A 18GLY A 20GLY A 206ASP A 208VAL A 236 | None | 0.79A | 1ffyA-4g6zA:13.2 | 1ffyA-4g6zA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnr | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN-BRANCHEDCHAIN AMINO ACIDTRANSPORT (Streptococcuspneumoniae) |
PF13458(Peripla_BP_6) | 5 | GLY A 266ASN A 265SER A 137GLY A 263VAL A 270 | NoneNoneNoneILE A 401 (-3.6A)None | 1.23A | 1ffyA-4gnrA:undetectable | 1ffyA-4gnrA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j75 | TRYPTOPHANYL-TRNASYNTHETASE (Plasmodiumfalciparum) |
PF00579(tRNA-synt_1b) | 6 | GLY A 319SER A 343GLY A 453ASP A 455GLN A 456PHE A 482 | TYM A 701 (-3.6A)TYM A 701 (-3.6A)TYM A 701 (-2.9A)TYM A 701 (-3.2A)TYM A 701 (-3.4A)None | 1.13A | 1ffyA-4j75A:7.4 | 1ffyA-4j75A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j75 | TRYPTOPHANYL-TRNASYNTHETASE (Plasmodiumfalciparum) |
PF00579(tRNA-synt_1b) | 5 | HIS A 320GLY A 319GLY A 453ASP A 455GLN A 456 | TYM A 701 ( 4.8A)TYM A 701 (-3.6A)TYM A 701 (-2.9A)TYM A 701 (-3.2A)TYM A 701 (-3.4A) | 1.13A | 1ffyA-4j75A:7.4 | 1ffyA-4j75A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jx6 | PYRUVATE CARBOXYLASE (Rhizobium etli) |
PF00682(HMGL-like)PF02436(PYC_OADA) | 5 | GLY A 622ASN A 662SER A 920PHE A 654VAL A 653 | NoneNoneNoneKCX A 718 ( 4.0A)None | 1.13A | 1ffyA-4jx6A:undetectable | 1ffyA-4jx6A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7d | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase) | 5 | PRO A 290HIS A 306GLY A 310ASN A 331GLY A 337 | None | 1.14A | 1ffyA-4o7dA:undetectable | 1ffyA-4o7dA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oud | TYROSYL-TRNASYNTHETASE (Escherichiacoli) |
PF00579(tRNA-synt_1b) | 5 | HIS B 48GLY B 50GLY B 198ASP B 200GLN B 201 | HIS B 48 ( 1.0A)GLY B 50 ( 0.0A)GLY B 198 ( 0.0A)ASP B 200 ( 0.6A)GLN B 201 ( 0.6A) | 0.59A | 1ffyA-4oudB:5.1 | 1ffyA-4oudB:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qqs | GLYCOSIDE HYDROLASEFAMILY 43 (Halothermothrixorenii) |
PF04616(Glyco_hydro_43) | 5 | HIS A 273GLY A 255ASN A 257GLY A 196ASP A 126 | NoneNoneNone NA A 402 ( 4.6A)EPE A 401 (-2.7A) | 1.22A | 1ffyA-4qqsA:undetectable | 1ffyA-4qqsA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uul | L-LACTATEDEHYDROGENASE (Trichomonasvaginalis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 184ASN A 185SER A 88GLY A 187VAL A 191 | None | 1.14A | 1ffyA-4uulA:undetectable | 1ffyA-4uulA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2r | ANGIOTENSIN-CONVERTING ENZYME (Drosophilamelanogaster) |
PF01401(Peptidase_M2) | 5 | PRO A 482GLY A 252GLY A 478ASP A 474HIS A 232 | None | 1.23A | 1ffyA-5a2rA:undetectable | 1ffyA-5a2rA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3o | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase) | 5 | PRO A 295HIS A 311GLY A 315ASN A 336GLY A 342 | None | 1.22A | 1ffyA-5d3oA:undetectable | 1ffyA-5d3oA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djq | CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNITCCON1CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNITCCOP1 (Pseudomonasstutzeri) |
PF00115(COX1)PF13442(Cytochrome_CBB3)PF14715(FixP_N) | 5 | PRO C 53GLY A 290ASN A 289SER C 32VAL A 226 | None | 1.19A | 1ffyA-5djqC:3.2 | 1ffyA-5djqC:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ekd | TRYPTOPHAN--TRNALIGASE,MITOCHONDRIAL (Homo sapiens) |
PF00579(tRNA-synt_1b) | 5 | GLY A 50GLY A 179ASP A 181GLN A 182VAL A 217 | ATP A 402 (-3.6A)ATP A 402 (-3.0A)ATP A 402 (-2.9A)5BX A 401 ( 3.0A)ATP A 402 (-3.3A) | 0.83A | 1ffyA-5ekdA:4.1 | 1ffyA-5ekdA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ekd | TRYPTOPHAN--TRNALIGASE,MITOCHONDRIAL (Homo sapiens) |
PF00579(tRNA-synt_1b) | 5 | HIS A 48GLY A 50GLY A 179ASP A 181VAL A 217 | ATP A 402 (-4.0A)ATP A 402 (-3.6A)ATP A 402 (-3.0A)ATP A 402 (-2.9A)ATP A 402 (-3.3A) | 0.78A | 1ffyA-5ekdA:4.1 | 1ffyA-5ekdA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fnu | KELCH-LIKEECH-ASSOCIATEDPROTEIN 1 (Mus musculus) |
PF01344(Kelch_1) | 5 | HIS A 437GLY A 430ASN A 414GLY A 378MET A 456 | NoneNone CL A1616 (-3.5A)NoneNone | 1.25A | 1ffyA-5fnuA:undetectable | 1ffyA-5fnuA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsm | EXO-BETA-D-GLUCOSAMINIDASE (Thermococcuskodakarensis) |
PF02449(Glyco_hydro_42) | 5 | PRO A 412GLY A 383GLY A 408ASP A 407VAL A 30 | None | 1.14A | 1ffyA-5gsmA:undetectable | 1ffyA-5gsmA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ho9 | EXTRACELLULARARABINANASE (Geobacillusstearothermophilus) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 5 | HIS A 412GLY A 394ASN A 396GLY A 305ASP A 238 | NoneNoneNoneNoneAHR A 720 ( 4.9A) | 1.29A | 1ffyA-5ho9A:undetectable | 1ffyA-5ho9A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hp6 | EXTRACELLULARARABINANASE (Geobacillusstearothermophilus) |
PF04616(Glyco_hydro_43)PF13385(Laminin_G_3)PF16369(GH43_C) | 5 | HIS A 412GLY A 394ASN A 396GLY A 305ASP A 238 | NoneNoneNone CA A 902 ( 4.5A)TRS A 903 (-2.7A) | 1.30A | 1ffyA-5hp6A:undetectable | 1ffyA-5hp6A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jip | CORTICAL-LYTICENZYME (Clostridiumperfringens) |
PF01183(Glyco_hydro_25) | 5 | PRO A 117HIS A 74GLY A 44SER A 121GLY A 48 | None | 1.14A | 1ffyA-5jipA:undetectable | 1ffyA-5jipA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0t | METHIONINE--TRNALIGASE (Brucella suis) |
PF08264(Anticodon_1)PF09334(tRNA-synt_1g) | 5 | GLY A 22GLY A 262ASP A 264HIS A 291PHE A 293 | None | 0.58A | 1ffyA-5k0tA:24.4 | 1ffyA-5k0tA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0t | METHIONINE--TRNALIGASE (Brucella suis) |
PF08264(Anticodon_1)PF09334(tRNA-synt_1g) | 5 | HIS A 23GLY A 22GLY A 262ASP A 264HIS A 291 | None | 1.21A | 1ffyA-5k0tA:24.4 | 1ffyA-5k0tA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lw7 | ABC TRANSPORTERATP-BINDING PROTEIN (Pyrococcusabyssi) |
PF00005(ABC_tran)PF00037(Fer4)PF04068(RLI) | 5 | GLY B 302ASN B 305ASP B 278VAL B 283MET B 104 | None | 1.26A | 1ffyA-5lw7B:undetectable | 1ffyA-5lw7B:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8b | ALPHA-L-ARABINOFURANOSIDASE II (Lactobacillusbrevis) |
PF04616(Glyco_hydro_43) | 5 | HIS A 283GLY A 265ASN A 267GLY A 203ASP A 141 | NoneNoneNoneTRS A 402 ( 4.3A)TRS A 402 (-3.0A) | 1.20A | 1ffyA-5m8bA:undetectable | 1ffyA-5m8bA:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8e | ALPHA-N-ARABINOFURANOSIDASE (Weissellacibaria) |
PF04616(Glyco_hydro_43) | 5 | HIS A 281GLY A 263ASN A 265GLY A 201ASP A 139 | NoneNoneNone CA A 401 ( 4.9A)GOL A 403 ( 3.9A) | 1.17A | 1ffyA-5m8eA:undetectable | 1ffyA-5m8eA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr1 | CHLORIDE CHANNELPROTEIN (Bos taurus) |
PF00654(Voltage_CLC) | 5 | PRO A 420GLY A 122SER A 328GLY A 424VAL A 170 | None | 1.17A | 1ffyA-5tr1A:undetectable | 1ffyA-5tr1A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqe | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF04960(Glutaminase)PF12796(Ank_2) | 5 | PRO A 290HIS A 306GLY A 310ASN A 331GLY A 337 | None | 1.30A | 1ffyA-5uqeA:undetectable | 1ffyA-5uqeA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wx1 | SERINE PROTEASE NS3 (Pestivirus C) |
PF00271(Helicase_C)PF05578(Peptidase_S31)PF07652(Flavi_DEAD) | 5 | GLY A 164SER A 172GLY A 177ASP A 106VAL A 67 | None | 1.26A | 1ffyA-5wx1A:undetectable | 1ffyA-5wx1A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xya | - (-) |
no annotation | 5 | HIS A1566ASN A1563SER A 356GLY A 930GLN A 929 | None | 1.16A | 1ffyA-5xyaA:undetectable | 1ffyA-5xyaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | 40S RIBOSOMALPROTEIN SAUNCHARACTERIZEDPROTEIN (Trichomonasvaginalis) |
PF00318(Ribosomal_S2)PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 5 | ASN A 95SER C 259GLY A 93PHE A 88VAL A 85 | None | 1.07A | 1ffyA-5xyiA:undetectable | 1ffyA-5xyiA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yvs | ALCOHOLDEHYDROGENASE (candidatedivison MSBL1archaeonSCGC-AAA259E19) |
no annotation | 5 | GLY A 153SER A 280GLY A 98ASP A 102VAL A 156 | NoneNoneNDP A 502 (-2.6A)NDP A 502 (-2.6A)None | 1.27A | 1ffyA-5yvsA:undetectable | 1ffyA-5yvsA:6.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ax8 | METHIONINE-TRNALIGASE (Mycobacteriumtuberculosis) |
no annotation | 5 | GLY A 20GLY A 261ASP A 263HIS A 290PHE A 292 | ME8 A 801 (-3.6A)ME8 A 801 (-2.9A)ME8 A 801 (-3.1A)ME8 A 801 (-4.7A)ME8 A 801 (-4.9A) | 0.61A | 1ffyA-6ax8A:23.3 | 1ffyA-6ax8A:6.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ax8 | METHIONINE-TRNALIGASE (Mycobacteriumtuberculosis) |
no annotation | 5 | HIS A 18GLY A 20GLY A 261ASP A 263HIS A 290 | ME8 A 801 (-3.8A)ME8 A 801 (-3.6A)ME8 A 801 (-2.9A)ME8 A 801 (-3.1A)ME8 A 801 (-4.7A) | 0.55A | 1ffyA-6ax8A:23.3 | 1ffyA-6ax8A:6.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ax8 | METHIONINE-TRNALIGASE (Mycobacteriumtuberculosis) |
no annotation | 5 | HIS A 21GLY A 20GLY A 261ASP A 263HIS A 290 | ME8 A 801 (-4.3A)ME8 A 801 (-3.6A)ME8 A 801 (-2.9A)ME8 A 801 (-3.1A)ME8 A 801 (-4.7A) | 1.28A | 1ffyA-6ax8A:23.3 | 1ffyA-6ax8A:6.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bj9 | ACETYL-COAACETYLTRANSFERASE A (Ascaris suum) |
no annotation | 5 | PRO A 61GLY A 116GLY A 33VAL A 256MET A 258 | None | 1.23A | 1ffyA-6bj9A:undetectable | 1ffyA-6bj9A:6.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f74 | ALCOHOL OXIDASE (Thermothelomycesthermophila) |
no annotation | 5 | GLY A 290ASN A 559SER A 496GLY A 557VAL A 582 | None | 1.12A | 1ffyA-6f74A:undetectable | 1ffyA-6f74A:6.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fmq | - (-) |
no annotation | 5 | HIS A 437GLY A 430ASN A 414GLY A 378MET A 456 | ACT A 703 (-4.3A)NoneNoneNoneNone | 1.28A | 1ffyA-6fmqA:undetectable | 1ffyA-6fmqA:undetectable |