SIMILAR PATTERNS OF AMINO ACIDS FOR 1FEM_A_REAA184

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		5 VAL A  61
MET A  73
LEU A  97
GLN A  98
HIS A 117
 None
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.38A 1femA-1iiuA:
22.7		 1femA-1iiuA:
79.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		9 VAL A  61
MET A  73
PHE A  77
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
TYR A 133
 None
RTL  A 176 ( 4.0A)
None
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
None
 0.50A 1femA-1iiuA:
22.7		 1femA-1iiuA:
79.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfr HEMOGLOBIN

(Paramphistomum
epiclitum) 		PF00042
(Globin) 		5 VAL A  18
PHE A 108
MET A 143
LEU A  78
HIS A  98
 None
HEM  A 148 (-4.2A)
HEM  A 148 (-3.7A)
None
HEM  A 148 (-3.3A)
 1.43A 1femA-1kfrA:
undetectable		 1femA-1kfrA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 MET A  73
PHE A  45
LEU A  97
GLN A 117
TYR A 133
 OLA  A1179 ( 4.9A)
OLA  A1179 (-4.6A)
None
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
 1.36A 1femA-2wq9A:
22.4		 1femA-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 VAL A  61
MET A  73
PHE A  77
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
GLN A 117
TYR A 133
 None
OLA  A1179 ( 4.9A)
None
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
 0.60A 1femA-2wq9A:
22.4		 1femA-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  77
MET A  88
TYR A  90
GLN A  98
HIS A 104
 None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.80A 1femA-3fmzA:
30.1		 1femA-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		7 VAL A  61
PHE A  77
MET A  88
TYR A  90
HIS A 104
GLN A 117
TYR A 133
 None
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
None
2T1  A 184 (-4.7A)
 0.60A 1femA-3fmzA:
30.1		 1femA-3fmzA:
92.35