SIMILAR PATTERNS OF AMINO ACIDS FOR 1FDU_C_ESTC353_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		12 SER A 142
VAL A 143
GLY A 144
LEU A 149
TYR A 155
GLY A 186
PRO A 187
TYR A 218
SER A 222
PHE A 259
MET A 279
VAL A 283
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-3.4A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
EST  A 350 (-4.1A)
None
None
EST  A 350 (-4.0A)
EST  A 350 (-3.7A)
None
 0.49A 1fduC-1a27A:
45.8		 1fduC-1a27A:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A  63
LEU A  95
GLY A 158
PHE A 105
VAL A 230
 None
 1.24A 1fduC-1cliA:
undetectable		 1fduC-1cliA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 SER A 272
VAL A 274
GLY A 275
GLY A 141
VAL A 208
 None
 1.02A 1fduC-1dcuA:
undetectable		 1fduC-1dcuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		5 GLY A 349
LEU A 286
TYR A 297
GLY A 344
PHE A 442
 None
 1.06A 1fduC-1dl2A:
undetectable		 1fduC-1dl2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 0.95A 1fduC-1e5wA:
undetectable		 1fduC-1e5wA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.08A 1fduC-1ef1A:
undetectable		 1fduC-1ef1A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		11 SER A 142
VAL A 143
GLY A 144
LEU A 149
TYR A 155
GLY A 186
PRO A 187
SER A 222
PHE A 259
MET A 279
VAL A 283
 EST  A 350 (-4.3A)
EST  A 350 (-4.8A)
EST  A 350 ( 4.5A)
EST  A 350 (-4.6A)
None
EST  A 350 (-4.0A)
EST  A 350 (-4.3A)
EST  A 350 (-4.4A)
EST  A 350 (-4.4A)
EST  A 350 (-3.6A)
EST  A 350 ( 4.9A)
 0.67A 1fduC-1fdwA:
41.8		 1fduC-1fdwA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		11 SER A 142
VAL A 143
GLY A 144
LEU A 149
TYR A 155
GLY A 186
TYR A 218
SER A 222
PHE A 259
MET A 279
VAL A 283
 EST  A 350 (-4.3A)
EST  A 350 (-4.8A)
EST  A 350 ( 4.5A)
EST  A 350 (-4.6A)
None
EST  A 350 (-4.0A)
None
EST  A 350 (-4.4A)
EST  A 350 (-4.4A)
EST  A 350 (-3.6A)
EST  A 350 ( 4.9A)
 0.56A 1fduC-1fdwA:
41.8		 1fduC-1fdwA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 VAL  A 220 ( 0.6A)
GLY  A 219 ( 0.0A)
LEU  A 218 ( 0.6A)
TYR  A 228 ( 1.3A)
GLY  A 224 ( 0.0A)
 1.00A 1fduC-1gc7A:
undetectable		 1fduC-1gc7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4r MERLIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 236
GLY A 235
LEU A 234
TYR A 244
GLY A 240
 None
 1.11A 1fduC-1h4rA:
undetectable		 1fduC-1h4rA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		5 SER A 152
VAL A 153
GLY A 154
TYR A 165
GLY A 196
 NAD  A1268 (-2.5A)
None
None
MRD  A1269 ( 3.9A)
NAD  A1268 (-3.8A)
 0.49A 1fduC-1iy8A:
28.8		 1fduC-1iy8A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 VAL F 106
GLY F 105
LEU F 218
GLY F 193
VAL F 262
 None
 0.86A 1fduC-1j8mF:
4.0		 1fduC-1j8mF:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 208
GLY A 209
GLY A 516
PHE A 562
VAL A 628
 None
 1.16A 1fduC-1po0A:
undetectable		 1fduC-1po0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 208
GLY A 209
LEU A 152
GLY A 516
VAL A 628
 None
 0.90A 1fduC-1po0A:
undetectable		 1fduC-1po0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		5 VAL A   7
GLY A  31
TYR A  55
GLY A  15
MET A  60
 None
None
None
None
NDP  A1501 (-4.8A)
 1.24A 1fduC-1rpnA:
18.0		 1fduC-1rpnA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE

(Spinacia
oleracea) 		PF00316
(FBPase) 		5 SER A 273
VAL A 275
GLY A 276
GLY A 143
SER A 196
 None
 0.94A 1fduC-1spiA:
undetectable		 1fduC-1spiA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu2 APOCYTOCHROME F

(Nostoc sp. PCC
7119) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 VAL B  72
GLY B  73
GLY B 121
PRO B 120
TYR B 102
 HEC  B 255 (-4.0A)
HEC  B 255 (-2.8A)
None
None
None
 1.20A 1fduC-1tu2B:
undetectable		 1fduC-1tu2B:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		5 VAL A  53
GLY A  54
LEU A 113
SER A 146
PHE A 118
 None
 0.86A 1fduC-1v19A:
5.0		 1fduC-1v19A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 SER A 264
GLY A 261
LEU A 300
GLY A 266
PHE A 217
 None
 1.20A 1fduC-1ve1A:
3.4		 1fduC-1ve1A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 VAL A 185
GLY A 186
GLY A 225
MET A 296
VAL A 303
 None
 0.96A 1fduC-1xi8A:
undetectable		 1fduC-1xi8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		5 GLY A2479
LEU A2484
GLY A2451
TYR A2307
SER A2308
 None
 1.18A 1fduC-1xktA:
4.1		 1fduC-1xktA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A 183
GLY A 182
LEU A 180
GLY A 170
SER A  18
 None
 0.82A 1fduC-1y8tA:
undetectable		 1fduC-1y8tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 VAL C 161
GLY C 164
LEU C 165
GLY C 158
MET C 336
 SMA  C 503 (-4.4A)
None
None
SMA  C 503 (-3.3A)
SMA  C 503 (-3.3A)
 1.12A 1fduC-1zrtC:
undetectable		 1fduC-1zrtC:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 SER A  89
VAL A  90
GLY A  91
GLY A  63
TYR A 288
 None
 0.98A 1fduC-2etvA:
undetectable		 1fduC-2etvA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE

(Pseudomonas
putida) 		PF04909
(Amidohydro_2) 		5 VAL A 106
GLY A 105
LEU A  76
GLY A 108
VAL A  21
 None
 1.22A 1fduC-2ffiA:
undetectable		 1fduC-2ffiA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 SER A 184
GLY A 192
PRO A 318
PHE A 182
VAL A 200
 None
 1.18A 1fduC-2fj0A:
undetectable		 1fduC-2fj0A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.15A 1fduC-2i1jA:
undetectable		 1fduC-2i1jA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lae LIPOPROTEIN 34

(Escherichia
coli) 		PF06804
(Lipoprotein_18) 		5 SER A 314
LEU A 255
GLY A 308
SER A 269
VAL A 266
 None
 1.15A 1fduC-2laeA:
undetectable		 1fduC-2laeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 VAL A 195
GLY A 196
GLY A 191
PHE A 164
VAL A   7
 None
 1.08A 1fduC-2om6A:
3.6		 1fduC-2om6A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 VAL A 161
GLY A 164
LEU A 165
GLY A 158
MET A 336
 SMA  A   1 (-4.1A)
None
None
SMA  A   1 (-3.1A)
SMA  A   1 (-3.6A)
 1.16A 1fduC-2qjpA:
undetectable		 1fduC-2qjpA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 SER A 156
LEU A 204
GLY A 149
SER A 181
VAL A 214
 None
None
SO4  A1275 (-3.2A)
None
None
 1.21A 1fduC-2vo1A:
2.1		 1fduC-2vo1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		5 GLY A 696
TYR A 609
PHE A 594
MET A 635
VAL A 678
 None
 1.24A 1fduC-2w92A:
undetectable		 1fduC-2w92A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 SER A 347
VAL A 225
GLY A 501
GLY A 349
MET A 481
 None
 0.93A 1fduC-2y8nA:
undetectable		 1fduC-2y8nA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME B

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 VAL A 161
GLY A 164
LEU A 165
GLY A 158
MET A 336
 SMA  A 502 (-4.3A)
None
None
SMA  A 502 (-3.5A)
SMA  A 502 (-3.6A)
 1.09A 1fduC-2yiuA:
undetectable		 1fduC-2yiuA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 407
GLY A 408
GLY A 404
PRO A 344
VAL A 177
 None
 1.04A 1fduC-2yquA:
undetectable		 1fduC-2yquA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		5 SER A 151
VAL A 152
GLY A 153
GLY A 195
SER A 218
 NAP  A1261 ( 3.4A)
None
None
None
None
 0.87A 1fduC-2zatA:
26.6		 1fduC-2zatA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		5 SER A 151
VAL A 152
GLY A 153
TYR A 164
GLY A 195
 NAP  A1261 ( 3.4A)
None
None
NAP  A1261 ( 4.6A)
None
 0.63A 1fduC-2zatA:
26.6		 1fduC-2zatA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 SER A 273
GLY A 272
LEU A 270
GLY A 219
VAL A 265
 FNR  A 669 ( 4.5A)
None
None
None
None
 1.11A 1fduC-3b05A:
undetectable		 1fduC-3b05A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		5 VAL A 208
GLY A 207
LEU A  93
PHE A 211
VAL A  46
 None
None
CL  A 335 ( 4.1A)
None
None
 1.23A 1fduC-3csvA:
undetectable		 1fduC-3csvA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacillus
halodurans) 		PF13460
(NAD_binding_10) 		5 SER A 110
VAL A 111
GLY A 112
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
CL  A 501 (-3.3A)
None
NAP  A 500 ( 4.9A)
 0.72A 1fduC-3e8xA:
17.6		 1fduC-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacillus
halodurans) 		PF13460
(NAD_binding_10) 		5 SER A 110
VAL A 111
TYR A 126
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
NAP  A 500 (-4.5A)
None
NAP  A 500 ( 4.9A)
 0.71A 1fduC-3e8xA:
17.6		 1fduC-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		5 SER A  81
VAL A  82
GLY A  83
LEU A 120
PHE A 100
 None
 1.23A 1fduC-3ebvA:
3.5		 1fduC-3ebvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		5 VAL A 267
GLY A 266
LEU A 326
TYR A 349
VAL A 345
 None
 1.11A 1fduC-3g8yA:
3.5		 1fduC-3g8yA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		5 VAL A 490
GLY A 491
SER A 456
PHE A 552
MET A 559
 None
 1.19A 1fduC-3hjeA:
undetectable		 1fduC-3hjeA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlt HDHD2

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 VAL A 216
GLY A 217
GLY A 212
PHE A 185
VAL A  10
 None
 1.14A 1fduC-3hltA:
undetectable		 1fduC-3hltA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 VAL A 259
GLY A 260
LEU A 265
GLY A 218
VAL A 184
 None
 1.19A 1fduC-3k40A:
undetectable		 1fduC-3k40A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 VAL E 265
GLY E 266
LEU E 316
GLY E 227
MET E 291
 None
 1.17A 1fduC-3kdsE:
undetectable		 1fduC-3kdsE:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		5 VAL A 176
LEU A 178
GLY A  62
SER A  72
MET A 242
 None
None
None
GDP  A 335 (-3.1A)
None
 1.19A 1fduC-3md0A:
3.8		 1fduC-3md0A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 SER A 290
GLY A 292
LEU A 341
GLY A  60
PHE A  64
 None
None
EDO  A 505 ( 4.7A)
None
EDO  A 505 (-3.8A)
 0.87A 1fduC-3myvA:
undetectable		 1fduC-3myvA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n70 TRANSPORT ACTIVATOR

(Escherichia
coli) 		PF14532
(Sigma54_activ_2) 		5 GLY A 178
GLY A 173
TYR A 199
SER A 225
VAL A 223
 SO4  A   1 (-3.2A)
None
None
None
None
 1.05A 1fduC-3n70A:
undetectable		 1fduC-3n70A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 GLY A 468
LEU A 467
GLY A 442
TYR A 455
VAL A 423
 None
 1.17A 1fduC-3o8lA:
4.2		 1fduC-3o8lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 VAL A 123
GLY A 124
LEU A 155
GLY A 119
TYR A 168
 None
 1.16A 1fduC-3oc7A:
undetectable		 1fduC-3oc7A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		5 SER A 461
GLY A 442
LEU A 444
GLY A 419
VAL A 424
 None
 1.23A 1fduC-3r31A:
3.0		 1fduC-3r31A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rtx MRNA-CAPPING ENZYME

(Mus musculus) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		5 VAL A 241
GLY A 240
SER A 409
PHE A 232
VAL A 356
 None
 1.20A 1fduC-3rtxA:
undetectable		 1fduC-3rtxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 SER A 643
VAL A 644
TYR A 656
GLY A 683
PRO A 684
 NDP  A 802 (-3.2A)
None
None
NDP  A 802 (-4.6A)
None
 0.85A 1fduC-3slkA:
8.1		 1fduC-3slkA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 164
VAL A 340
GLY A 339
GLY A 234
SER A  14
 None
 1.06A 1fduC-3u0fA:
undetectable		 1fduC-3u0fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 VAL A 152
GLY A 153
LEU A  37
GLY A 150
VAL A  11
 None
 1.21A 1fduC-3vlaA:
undetectable		 1fduC-3vlaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 VAL A 255
GLY A 256
TYR A 257
SER A 263
VAL A 239
 None
 0.92A 1fduC-3whiA:
3.2		 1fduC-3whiA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 5 GLY A 172
LEU A 173
GLY A 142
TYR A 117
MET A 111
 None
 1.11A 1fduC-4b2nA:
undetectable		 1fduC-4b2nA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		5 SER A 137
VAL A 138
LEU A 144
TYR A 150
GLY A 181
 NAP  A1250 (-3.1A)
None
None
NAP  A1250 (-4.8A)
NAP  A1250 (-4.9A)
 0.58A 1fduC-4bmsA:
28.0		 1fduC-4bmsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE

(Flavobacterium
sp. 141-8) 		PF13561
(adh_short_C2) 		5 SER A 153
VAL A 154
TYR A 166
GLY A 197
PRO A 198
 None
 0.50A 1fduC-4cr6A:
24.7		 1fduC-4cr6A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00215
(OMPdecase) 		5 SER A 189
GLY A 167
TYR A 173
GLY A 187
SER A 163
 None
None
None
BMP  A 301 (-3.3A)
None
 1.07A 1fduC-4dbeA:
undetectable		 1fduC-4dbeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		5 GLY A 184
GLY A 312
PRO A 313
PHE A 172
VAL A 192
 None
 1.12A 1fduC-4fnmA:
2.3		 1fduC-4fnmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilf THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Salmonella
enterica) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		5 VAL A  36
LEU A  67
GLY A  49
PRO A  50
VAL A 186
 None
 1.20A 1fduC-4ilfA:
undetectable		 1fduC-4ilfA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 GLY A 113
LEU A  26
GLY A 118
PHE A  60
VAL A   4
 None
 1.06A 1fduC-4j2uA:
undetectable		 1fduC-4j2uA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		5 VAL A 201
GLY A 198
LEU A 196
MET A 234
VAL A  79
 None
 0.90A 1fduC-4km3A:
undetectable		 1fduC-4km3A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 VAL A 187
GLY A 177
LEU A 205
GLY A 189
VAL A 211
 None
 1.23A 1fduC-4lc9A:
5.6		 1fduC-4lc9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		5 GLY A 342
LEU A  80
TYR A 279
PHE A 303
VAL A 282
 None
 0.99A 1fduC-4lcmA:
undetectable		 1fduC-4lcmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		5 GLY A 343
LEU A  80
TYR A 279
PHE A 303
VAL A 282
 None
 1.07A 1fduC-4lcmA:
undetectable		 1fduC-4lcmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		5 SER A 187
VAL A 184
GLY A 183
TYR A 178
GLY A 147
 None
 1.10A 1fduC-4ldqA:
4.6		 1fduC-4ldqA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF01884
(PcrB) 		5 VAL A 139
GLY A 143
LEU A  98
GLY A 136
MET A  96
 None
None
PGE  A 302 ( 3.6A)
None
PGE  A 302 ( 3.3A)
 1.21A 1fduC-4mm1A:
undetectable		 1fduC-4mm1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 SER A 265
VAL A 266
GLY A 263
LEU A 258
VAL A 221
 None
 1.10A 1fduC-4o3sA:
undetectable		 1fduC-4o3sA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12157
(DUF3591) 		5 VAL A 585
GLY A 586
LEU A 566
MET A 547
VAL A 658
 None
 1.16A 1fduC-4oy2A:
undetectable		 1fduC-4oy2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		5 VAL A 201
GLY A 202
LEU A 222
GLY A 199
VAL A 303
 None
 1.03A 1fduC-4rdyA:
2.0		 1fduC-4rdyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.11A 1fduC-4rm9A:
undetectable		 1fduC-4rm9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 VAL A 220
GLY A 219
LEU A 218
TYR A 228
GLY A 224
 None
 1.07A 1fduC-4rmaA:
undetectable		 1fduC-4rmaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Verminephrobacter
eiseniae) 		PF13407
(Peripla_BP_4) 		5 GLY A  39
LEU A  95
GLY A  91
SER A 113
VAL A 109
 None
None
GOL  A 403 (-3.3A)
None
None
 1.23A 1fduC-4ry9A:
6.5		 1fduC-4ry9A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6v DI-/TRIPEPTIDE
TRANSPORTER

(Yersinia
enterocolitica) 		PF00854
(PTR2) 		5 GLY A 128
LEU A 127
GLY A  79
PRO A  78
VAL A 243
 None
 1.15A 1fduC-4w6vA:
undetectable		 1fduC-4w6vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 SER A 153
VAL A 149
GLY A 150
LEU A  16
SER A 119
 3GP  A 402 ( 2.2A)
None
None
None
None
 1.22A 1fduC-4w8xA:
undetectable		 1fduC-4w8xA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 164
VAL A 337
GLY A 336
GLY A 234
SER A  14
 None
 1.03A 1fduC-4xoxA:
undetectable		 1fduC-4xoxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm8 RAS-RELATED PROTEIN
RAL-A

(Drosophila
melanogaster) 		PF00071
(Ras) 		5 VAL B  22
GLY B  23
LEU B  27
GLY B  18
VAL B 164
 None
 0.99A 1fduC-5cm8B:
6.1		 1fduC-5cm8B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dze ENDO-GLUCANASE

(Vitis vinifera) 		PF00722
(Glyco_hydro_16) 		5 SER A 169
VAL A 170
GLY A  44
TYR A 175
PHE A  39
 BGC  A 302 (-2.3A)
None
None
None
None
 0.98A 1fduC-5dzeA:
undetectable		 1fduC-5dzeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 VAL A 414
GLY A 415
LEU A 308
PHE A 432
VAL A 489
 None
 0.97A 1fduC-5e9uA:
7.0		 1fduC-5e9uA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 GLY B 758
LEU B 762
TYR B 759
GLY B 711
VAL B 723
 None
 1.15A 1fduC-5eduB:
4.7		 1fduC-5eduB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 SER B 755
GLY B 758
LEU B 762
GLY B 711
VAL B 723
 None
 1.23A 1fduC-5eduB:
4.7		 1fduC-5eduB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 5 GLY B 721
LEU B 725
TYR B 722
GLY B 674
VAL B 686
 None
 1.09A 1fduC-5efnB:
3.6		 1fduC-5efnB:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 5 SER A 574
VAL A 552
TYR A 578
GLY A 572
VAL A 522
 None
 1.24A 1fduC-5fkrA:
undetectable		 1fduC-5fkrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 SER A 129
GLY A 128
LEU A 494
GLY A 125
VAL A 413
 None
 1.23A 1fduC-5fp1A:
undetectable		 1fduC-5fp1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		5 GLY A 721
LEU A 725
TYR A 722
GLY A 674
VAL A 686
 None
None
None
EDO  A1809 (-3.7A)
None
 1.10A 1fduC-5g0hA:
2.5		 1fduC-5g0hA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h68 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF02463
(SMC_N) 		5 SER A 139
GLY A 134
LEU A  48
PRO A1112
VAL A 100
 None
 0.78A 1fduC-5h68A:
undetectable		 1fduC-5h68A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		5 SER A 141
VAL A 142
GLY A 143
TYR A 154
GLY A 185
 None
 0.49A 1fduC-5itwA:
27.7		 1fduC-5itwA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		5 SER A 340
VAL A 342
GLY A 343
GLY A 212
SER A 263
 None
 1.12A 1fduC-5iz1A:
undetectable		 1fduC-5iz1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 SER A 206
VAL A 207
TYR A 219
GLY A 250
PRO A 251
 NAD  A 901 (-3.1A)
None
NAD  A 901 (-4.6A)
IOD  A 903 (-4.5A)
IOD  A 903 (-4.4A)
 0.61A 1fduC-5jydA:
25.4		 1fduC-5jydA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase)
PF12796
(Ank_2) 		5 SER A 502
GLY A 262
GLY A 487
SER A 428
PHE A 282
 None
 1.24A 1fduC-5uqeA:
undetectable		 1fduC-5uqeA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve2 ENOYL-COA HYDRATASE

(Pseudoalteromonas
atlantica) 		PF00378
(ECH_1) 		5 LEU A  35
TYR A  32
GLY A 107
PHE A  60
VAL A  51
 LEU  A  35 ( 0.6A)
TYR  A  32 ( 1.3A)
GLY  A 107 ( 0.0A)
PHE  A  60 ( 1.3A)
VAL  A  51 ( 0.6A)
 1.10A 1fduC-5ve2A:
undetectable		 1fduC-5ve2A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 SER A 269
VAL A 270
GLY A 271
GLY A 441
PHE A 314
 None
 1.23A 1fduC-5w4xA:
7.9		 1fduC-5w4xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3t E3 UBIQUITIN-PROTEIN
LIGASE RNF31
SHARPIN

(Mus musculus) 		no annotation 5 VAL B 486
LEU C 229
GLY B 482
SER C 231
PHE C 293
 None
 1.07A 1fduC-5y3tB:
undetectable		 1fduC-5y3tB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 SER D 104
LEU D  69
GLY D  96
PRO D  75
VAL D  45
 None
 1.10A 1fduC-6cg0D:
undetectable		 1fduC-6cg0D:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cim V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 2

(Mus musculus) 		no annotation 5 SER B 104
LEU B  69
GLY B  96
PRO B  75
VAL B  45
 None
 1.05A 1fduC-6cimB:
undetectable		 1fduC-6cimB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egt GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 5 SER A 725
GLY A 724
LEU A 694
GLY A 727
VAL A1023
 None
 1.19A 1fduC-6egtA:
undetectable		 1fduC-6egtA:
19.74