SIMILAR PATTERNS OF AMINO ACIDS FOR 1FDU_B_ESTB354_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0i DNA LIGASE

(Escherichia
virus T7) 		PF01068
(DNA_ligase_A_M) 		4 SER A  50
VAL A  44
LEU A  90
VAL A 174
 None
 0.98A 1fduB-1a0iA:
undetectable		 1fduB-1a0iA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		8 SER A 142
VAL A 143
LEU A 149
TYR A 155
PRO A 187
TYR A 218
MET A 279
VAL A 283
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
None
EST  A 350 (-3.7A)
None
 0.48A 1fduB-1a27A:
44.5		 1fduB-1a27A:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		4 SER A 143
VAL A 144
LEU A 105
TYR A 153
 NA  A 622 (-2.6A)
None
None
NA  A 622 (-4.6A)
 1.03A 1fduB-1bg4A:
1.9		 1fduB-1bg4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo6 ESTROGEN
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 VAL A  31
LEU A 109
MET A  20
VAL A  18
 None
 1.09A 1fduB-1bo6A:
2.1		 1fduB-1bo6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dly HEMOGLOBIN

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 SER A 110
VAL A 108
LEU A  53
VAL A  12
 None
 1.05A 1fduB-1dlyA:
undetectable		 1fduB-1dlyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 SER A  46
VAL A  43
LEU A  56
VAL A 214
 ADP  A1366 ( 3.9A)
None
None
None
 1.09A 1fduB-1ea6A:
undetectable		 1fduB-1ea6A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f53 YEAST KILLER
TOXIN-LIKE PROTEIN

(Streptomyces
sp.) 		PF09076
(Crystall_2) 		4 SER A  60
VAL A  61
LEU A  51
TYR A  28
 None
 0.93A 1fduB-1f53A:
undetectable		 1fduB-1f53A:
10.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		8 SER A 142
VAL A 143
LEU A 149
TYR A 155
PRO A 187
TYR A 218
MET A 279
VAL A 283
 EST  A 350 (-4.3A)
EST  A 350 (-4.8A)
EST  A 350 (-4.6A)
None
EST  A 350 (-4.3A)
None
EST  A 350 (-3.6A)
EST  A 350 ( 4.9A)
 0.70A 1fduB-1fdwA:
40.8		 1fduB-1fdwA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 SER A 160
VAL A 159
LEU A 157
VAL A 144
 None
 1.09A 1fduB-1i9gA:
6.8		 1fduB-1i9gA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 VAL A  92
TYR A 106
TYR A 245
VAL A 241
 None
 0.82A 1fduB-1kfiA:
undetectable		 1fduB-1kfiA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd H57 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER E 176
LEU F 187
TYR F 147
VAL F 152
 None
 1.09A 1fduB-1nfdE:
undetectable		 1fduB-1nfdE:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 LEU A 370
TYR A 369
PRO A 328
VAL A 350
 None
 1.04A 1fduB-1sc6A:
5.6		 1fduB-1sc6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B
CYTOLETHAL
DISTENDING TOXIN
PROTEIN C

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos)
PF03498
(CDtoxinA) 		4 VAL B 147
PRO B  87
TYR C  29
VAL B 118
 None
 1.05A 1fduB-1sr4B:
undetectable		 1fduB-1sr4B:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 SER A 110
VAL A 108
LEU A  53
VAL A  12
 None
None
None
XE  A1125 ( 4.6A)
 1.09A 1fduB-1uvxA:
undetectable		 1fduB-1uvxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbr ENDO-1,4-BETA-XYLANA
SE B

(Thermotoga
maritima) 		PF00331
(Glyco_hydro_10) 		4 SER A 658
VAL A 659
LEU A 620
TYR A 668
 None
 0.93A 1fduB-1vbrA:
2.1		 1fduB-1vbrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcj HYPOTHETICAL PROTEIN
TM0487

(Thermotoga
maritima) 		PF01883
(FeS_assembly_P) 		4 VAL A  18
LEU A  15
MET A  48
VAL A  46
 None
 1.05A 1fduB-1wcjA:
undetectable		 1fduB-1wcjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb3 HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF11447
(DUF3201) 		4 SER A  37
VAL A  36
PRO A  58
VAL A 150
 None
 1.06A 1fduB-1yb3A:
undetectable		 1fduB-1yb3A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130

(Homo sapiens) 		PF00179
(UQ_con) 		4 SER A  46
VAL A  47
LEU A 144
PRO A 119
 None
 0.95A 1fduB-1yrvA:
undetectable		 1fduB-1yrvA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57

(Trypanosoma
brucei) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 VAL A 426
TYR A 273
TYR A 319
VAL A 323
 None
 1.06A 1fduB-2b4vA:
undetectable		 1fduB-2b4vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 SER A 353
LEU A 301
TYR A 304
PRO A 384
 None
 1.02A 1fduB-2bwsA:
undetectable		 1fduB-2bwsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpc KIAA0657 PROTEIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 VAL A  31
LEU A  70
PRO A  73
VAL A  53
 None
 0.97A 1fduB-2cpcA:
undetectable		 1fduB-2cpcA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9r CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF08922
(DUF1905) 		4 VAL A  99
LEU A 101
TYR A  49
VAL A  54
 None
 1.05A 1fduB-2d9rA:
undetectable		 1fduB-2d9rA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 SER A 164
VAL A 165
LEU A 122
TYR A 174
 None
 0.89A 1fduB-2f8qA:
undetectable		 1fduB-2f8qA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvg ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 SER A  58
VAL A  57
TYR A 292
VAL A 338
 None
None
EDO  A 342 (-4.3A)
None
 0.95A 1fduB-2fvgA:
undetectable		 1fduB-2fvgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		4 TYR A 277
TYR A 180
MET A 201
VAL A 158
 None
 1.04A 1fduB-2horA:
undetectable		 1fduB-2horA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 VAL A 318
LEU A 323
MET A 188
VAL A 343
 None
 0.99A 1fduB-2i4nA:
undetectable		 1fduB-2i4nA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lru SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Rattus
norvegicus) 		PF12202
(OSR1_C) 		4 VAL A 485
LEU A 504
MET A 540
VAL A 536
 None
 0.99A 1fduB-2lruA:
undetectable		 1fduB-2lruA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		4 VAL A  17
TYR A 174
PRO A  15
VAL A 169
 None
 0.99A 1fduB-2oseA:
undetectable		 1fduB-2oseA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4f SIMILAR TO SP|P32453
SACCHAROMYCES
CEREVISIAE YNL315C
ATP11

([Candida]
glabrata) 		PF06644
(ATP11) 		4 SER A 242
VAL A 241
LEU A 249
VAL A 183
 None
 1.09A 1fduB-2p4fA:
undetectable		 1fduB-2p4fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2taa TAKA-AMYLASE A

(Aspergillus
oryzae) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 SER A 409
LEU A 462
TYR A 427
VAL A 444
 None
 0.84A 1fduB-2taaA:
undetectable		 1fduB-2taaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 SER A 111
LEU A  42
TYR A  15
VAL A   6
 SFD  A1418 (-2.8A)
SFD  A1418 (-4.4A)
None
None
 1.07A 1fduB-2vfvA:
undetectable		 1fduB-2vfvA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 SER A 537
VAL A 536
LEU A 531
PRO A 478
 None
 1.06A 1fduB-2vycA:
4.7		 1fduB-2vycA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 4 SER A 390
LEU A 383
TYR A 661
MET A 379
 None
 1.08A 1fduB-2wb7A:
undetectable		 1fduB-2wb7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv) 		4 SER 3   7
VAL 3   8
MET 3  15
VAL 3  18
 None
 1.06A 1fduB-2ws93:
undetectable		 1fduB-2ws93:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 VAL A 426
LEU A 347
PRO A 334
VAL A 381
 None
 1.01A 1fduB-2x9xA:
undetectable		 1fduB-2x9xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0r PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0547

(Thermus
thermophilus) 		PF11572
(DUF3234) 		4 SER A  30
VAL A  77
LEU A  66
VAL A 100
 None
 1.01A 1fduB-2z0rA:
undetectable		 1fduB-2z0rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 SER A 424
LEU A 158
TYR A 154
MET A 164
 None
 1.04A 1fduB-2z23A:
undetectable		 1fduB-2z23A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 TYR A 365
TYR A 273
MET A 297
VAL A 482
 None
 1.07A 1fduB-2z23A:
undetectable		 1fduB-2z23A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 VAL A 289
LEU A 293
PRO A 283
VAL A 390
 None
 1.03A 1fduB-2z23A:
undetectable		 1fduB-2z23A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvf ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF02272
(DHHA1) 		4 VAL A 896
LEU A 888
MET A 839
VAL A 846
 None
 1.04A 1fduB-2zvfA:
undetectable		 1fduB-2zvfA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asp CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 LEU A 256
TYR A 431
PRO A 423
VAL A 531
 None
 1.07A 1fduB-3aspA:
undetectable		 1fduB-3aspA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 SER A 338
TYR A  58
MET A 387
VAL A 392
 None
 1.08A 1fduB-3bs8A:
undetectable		 1fduB-3bs8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdd PROPHAGE MUSO2, 43
KDA TAIL PROTEIN

(Shewanella
oneidensis) 		PF05954
(Phage_GPD) 		4 LEU A 312
TYR A 283
MET A 316
VAL A 336
 None
 0.98A 1fduB-3cddA:
undetectable		 1fduB-3cddA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR-SORTING
PROTEIN SNF8

(Homo sapiens) 		PF04157
(EAP30) 		4 SER A  88
VAL A  93
TYR A  98
PRO A  79
 None
 1.02A 1fduB-3cuqA:
undetectable		 1fduB-3cuqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 SER A 151
VAL A 150
PRO A 154
VAL A  47
 None
 0.88A 1fduB-3dd6A:
undetectable		 1fduB-3dd6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 LEU A 120
TYR A 123
MET A 105
VAL A 219
 None
 1.02A 1fduB-3dm5A:
undetectable		 1fduB-3dm5A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		4 SER A 149
VAL A 150
LEU A 152
MET A 188
 None
 0.98A 1fduB-3e5mA:
13.5		 1fduB-3e5mA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Bacillus
halodurans) 		PF13460
(NAD_binding_10) 		4 SER A 110
VAL A 111
TYR A 126
PRO A 151
 NAP  A 500 (-3.1A)
None
NAP  A 500 (-4.5A)
NAP  A 500 ( 4.9A)
 1.00A 1fduB-3e8xA:
17.6		 1fduB-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 SER A 116
VAL A 115
TYR A  52
MET A 105
 None
 0.94A 1fduB-3e9zA:
undetectable		 1fduB-3e9zA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epm THIAMINE
BIOSYNTHESIS PROTEIN
THIC

(Caulobacter
vibrioides) 		PF01964
(ThiC_Rad_SAM)
PF13667
(ThiC-associated) 		4 SER A 268
VAL A 269
PRO A  58
VAL A 490
 None
 1.07A 1fduB-3epmA:
2.7		 1fduB-3epmA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 SER A 403
VAL A 404
LEU A 217
VAL A 449
 None
 0.85A 1fduB-3geiA:
3.6		 1fduB-3geiA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		4 SER A  81
VAL A  82
TYR A  59
MET A 121
 None
 0.98A 1fduB-3gmiA:
undetectable		 1fduB-3gmiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		4 SER B 145
VAL B 144
TYR B 208
VAL B 231
 None
 0.97A 1fduB-3hhrB:
undetectable		 1fduB-3hhrB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens) 		PF04437
(RINT1_TIP1) 		4 VAL A 620
LEU A 656
MET A 660
VAL A 718
 None
 1.01A 1fduB-3hr0A:
undetectable		 1fduB-3hr0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 223
PRO A 164
MET A 241
VAL A 243
 None
 0.96A 1fduB-3hskA:
6.7		 1fduB-3hskA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx3 RETINALDEHYDE-BINDIN
G PROTEIN 1

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 SER A 230
LEU A 184
MET A 159
VAL A 157
 None
 1.04A 1fduB-3hx3A:
undetectable		 1fduB-3hx3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx8 PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		4 VAL A  66
LEU A  64
TYR A  42
VAL A  80
 None
 0.84A 1fduB-3jx8A:
undetectable		 1fduB-3jx8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		4 SER A  14
VAL A  15
LEU A 302
MET A  46
 None
 1.08A 1fduB-3m8yA:
undetectable		 1fduB-3m8yA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mln TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF16422
(COE1_DBD) 		4 VAL A 128
LEU A 130
MET A 232
VAL A 234
 None
 0.97A 1fduB-3mlnA:
undetectable		 1fduB-3mlnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN

(Bos taurus) 		PF10409
(PTEN_C2) 		4 VAL A  88
TYR A 103
MET A  73
VAL A 158
 None
 0.99A 1fduB-3n0aA:
undetectable		 1fduB-3n0aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		4 SER A 173
VAL A 172
PRO A 176
VAL A 219
 None
 0.81A 1fduB-3oc6A:
undetectable		 1fduB-3oc6A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 VAL A 225
LEU A 223
PRO A 281
VAL A 336
 None
 0.98A 1fduB-3oepA:
undetectable		 1fduB-3oepA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5

(Saccharomyces
cerevisiae) 		PF00397
(WW)
PF00632
(HECT) 		4 SER A 774
VAL A 781
LEU A 733
PRO A 772
 None
 0.81A 1fduB-3olmA:
undetectable		 1fduB-3olmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3paf 50S RIBOSOMAL
PROTEIN L7AE

(Methanocaldococcus
jannaschii) 		PF01248
(Ribosomal_L7Ae) 		5 VAL A 112
LEU A  17
TYR A  74
PRO A  71
VAL A  21
 None
 1.47A 1fduB-3pafA:
undetectable		 1fduB-3pafA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 SER A  42
VAL A  39
LEU A  35
VAL A 259
 None
 1.03A 1fduB-3pkjA:
2.8		 1fduB-3pkjA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 SER A 513
LEU A 661
TYR A 640
PRO A 509
 None
 1.08A 1fduB-3pocA:
undetectable		 1fduB-3pocA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		4 SER A 244
VAL A 243
LEU A 240
VAL A 274
 None
 1.09A 1fduB-3qqzA:
undetectable		 1fduB-3qqzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpk BACKBONE PILUS
SUBUNIT

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 VAL A 426
LEU A 347
PRO A 334
VAL A 381
 None
 0.93A 1fduB-3rpkA:
undetectable		 1fduB-3rpkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 VAL B 246
LEU B 229
PRO B 242
MET B 195
 None
 0.93A 1fduB-3s4wB:
undetectable		 1fduB-3s4wB:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7i ALLERGEN ARA H 1,
CLONE P41B

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		4 SER A 272
VAL A 247
LEU A 264
PRO A 267
 None
 0.95A 1fduB-3s7iA:
undetectable		 1fduB-3s7iA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0q AGR253WP

(Eremothecium
gossypii) 		PF00225
(Kinesin) 		4 LEU A 664
TYR A 663
MET A 585
VAL A 583
 None
 1.07A 1fduB-3t0qA:
undetectable		 1fduB-3t0qA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 TYR A 391
TYR A 299
MET A 323
VAL A 508
 None
 1.02A 1fduB-3tchA:
undetectable		 1fduB-3tchA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tee FLAGELLA BASAL BODY
P-RING FORMATION
PROTEIN FLGA

(Salmonella
enterica) 		PF13144
(ChapFlgA) 		4 SER A 157
VAL A 158
MET A 178
VAL A 176
 None
 0.70A 1fduB-3teeA:
undetectable		 1fduB-3teeA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 SER A 221
TYR A 192
TYR A  22
VAL A 175
 CA  A 801 ( 4.6A)
None
None
None
 1.06A 1fduB-3texA:
undetectable		 1fduB-3texA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		4 SER A 142
VAL A 143
LEU A 104
TYR A 152
 None
 1.09A 1fduB-3u7bA:
2.3		 1fduB-3u7bA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A4687
VAL A4688
MET A4642
VAL A4639
 None
 1.07A 1fduB-3vkgA:
undetectable		 1fduB-3vkgA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu4 KMHSV2

(Kluyveromyces
marxianus) 		no annotation 4 SER A 289
VAL A 261
LEU A 259
VAL A 316
 None
 1.02A 1fduB-3vu4A:
undetectable		 1fduB-3vu4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		4 SER A 109
VAL A 235
TYR A  24
VAL A 258
 None
 0.95A 1fduB-3w9uA:
undetectable		 1fduB-3w9uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 SER A 518
PRO A 564
TYR A 662
VAL A 660
 None
 1.05A 1fduB-3wdjA:
2.0		 1fduB-3wdjA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 SER A 383
PRO A 449
TYR A 114
VAL A 119
 None
LYS  A 801 (-4.4A)
None
None
 1.08A 1fduB-3wevA:
undetectable		 1fduB-3wevA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
sp.) 		PF00331
(Glyco_hydro_10) 		4 SER A 177
VAL A 178
LEU A 139
TYR A 187
 None
 1.03A 1fduB-3wufA:
undetectable		 1fduB-3wufA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 LEU A 430
TYR A 273
PRO A 409
MET A 325
 None
 1.01A 1fduB-3zgbA:
undetectable		 1fduB-3zgbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhn PA_0080

(Pseudomonas
aeruginosa) 		PF12790
(T6SS-SciN) 		4 SER A 119
VAL A  12
LEU A  86
VAL A  67
 None
 1.09A 1fduB-3zhnA:
undetectable		 1fduB-3zhnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		4 SER A 422
VAL A 421
TYR A 337
VAL A 383
 None
 0.96A 1fduB-3zxsA:
undetectable		 1fduB-3zxsA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 VAL A 322
LEU A 325
PRO A 320
MET A 358
 None
 1.03A 1fduB-3zzuA:
undetectable		 1fduB-3zzuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

([Clostridium]
clariflavum) 		PF00942
(CBM_3) 		4 LEU A  37
PRO A  96
TYR A  60
VAL A 103
 None
 0.97A 1fduB-4b96A:
undetectable		 1fduB-4b96A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 SER A 723
VAL A 724
TYR A 688
VAL A 339
 None
 0.94A 1fduB-4bevA:
undetectable		 1fduB-4bevA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		4 SER A 137
VAL A 138
LEU A 144
TYR A 150
 NAP  A1250 (-3.1A)
None
None
NAP  A1250 (-4.8A)
 0.84A 1fduB-4bmsA:
28.1		 1fduB-4bmsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr6 N-ACYLMANNOSAMINE
1-DEHYDROGENASE

(Flavobacterium
sp. 141-8) 		PF13561
(adh_short_C2) 		4 SER A 153
VAL A 154
TYR A 166
PRO A 198
 None
 0.74A 1fduB-4cr6A:
24.6		 1fduB-4cr6A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 VAL A 845
LEU A 663
PRO A 842
TYR A 665
 None
 0.93A 1fduB-4czwA:
undetectable		 1fduB-4czwA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A 331
LEU A 162
MET A 171
VAL A 233
 None
 0.99A 1fduB-4dpkA:
undetectable		 1fduB-4dpkA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A1232
VAL A1231
TYR A1224
MET A1210
 None
 1.08A 1fduB-4e9xA:
undetectable		 1fduB-4e9xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 VAL A 141
LEU A 139
MET A  76
VAL A  74
 None
 0.91A 1fduB-4ecnA:
undetectable		 1fduB-4ecnA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacteroides
abscessus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 SER A 263
VAL A 262
PRO A 267
VAL A 291
 None
 1.09A 1fduB-4emdA:
undetectable		 1fduB-4emdA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE

(Penicillium
canescens) 		PF00331
(Glyco_hydro_10) 		4 SER A 169
VAL A 170
LEU A 131
TYR A 179
 None
 1.01A 1fduB-4f8xA:
undetectable		 1fduB-4f8xA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 VAL A 330
LEU A 333
PRO A 328
MET A 366
 None
 1.00A 1fduB-4fn5A:
undetectable		 1fduB-4fn5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12

(Saccharomyces
cerevisiae) 		no annotation 4 SER A 301
VAL A 293
LEU A 280
TYR A 342
 None
 1.10A 1fduB-4h5iA:
undetectable		 1fduB-4h5iA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		4 VAL A 166
TYR A 159
TYR A 344
VAL A 151
 None
HEM  A 401 (-4.4A)
None
None
 1.10A 1fduB-4hkaA:
undetectable		 1fduB-4hkaA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 VAL A 158
LEU A  56
TYR A 161
VAL A 124
 None
 1.05A 1fduB-4jo5A:
undetectable		 1fduB-4jo5A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 SER A 417
VAL A 416
LEU A  57
VAL A  21
 None
 1.04A 1fduB-4k9qA:
undetectable		 1fduB-4k9qA:
20.48