SIMILAR PATTERNS OF AMINO ACIDS FOR 1FBY_B_9CRB1500
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1air | PECTATE LYASE C (Dickeyachrysanthemi) |
PF00544(Pec_lyase_C) | 5 | ILE A 33ALA A 36ALA A 35ALA A 49VAL A 82 | None | 0.97A | 1fbyB-1airA:undetectable | 1fbyB-1airA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bue | PROTEIN(IMIPENEM-HYDROLYSING BETA-LACTAMASE) (Enterobactercloacae) |
PF13354(Beta-lactamase2) | 5 | ALA A 77ALA A 78LEU A 127ALA A 123VAL A 249 | None | 1.06A | 1fbyB-1bueA:undetectable | 1fbyB-1bueA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dqu | ISOCITRATE LYASE (Aspergillusnidulans) |
PF00463(ICL) | 5 | ILE A 166ALA A 192ALA A 191LEU A 59ALA A 56 | None | 0.96A | 1fbyB-1dquA:undetectable | 1fbyB-1dquA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dy6 | CARBAPENEM-HYDROLYSING BETA-LACTAMASESME-1 (Serratiamarcescens) |
PF13354(Beta-lactamase2) | 5 | ALA A 77ALA A 78LEU A 127ALA A 123VAL A 249 | None | 1.02A | 1fbyB-1dy6A:undetectable | 1fbyB-1dy6A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e19 | CARBAMATE KINASE (Pyrococcusfuriosus) |
PF00696(AA_kinase) | 5 | ILE A 37ALA A 34LEU A 97ALA A 96VAL A 5 | None | 0.81A | 1fbyB-1e19A:undetectable | 1fbyB-1e19A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc4 | 2-AMINO-3-KETOBUTYRATE CONENZYME ALIGASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | ILE A 238ALA A 255ALA A 256LEU A 100ALA A 97 | None | 0.99A | 1fbyB-1fc4A:undetectable | 1fbyB-1fc4A:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7w | DIHYDROPYRIMIDINEDEHYDROGENASE (Sus scrofa) |
PF01180(DHO_dh)PF07992(Pyr_redox_2)PF14691(Fer4_20)PF14697(Fer4_21) | 5 | ILE A 435CYH A 347ALA A 351ALA A 348ALA A 356 | None | 1.08A | 1fbyB-1h7wA:undetectable | 1fbyB-1h7wA:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1in8 | HOLLIDAY JUNCTIONDNA HELICASE RUVB (Thermotogamaritima) |
PF05491(RuvB_C)PF05496(RuvB_N) | 5 | ALA A 283ALA A 281LEU A 293ALA A 290VAL A 316 | None | 1.08A | 1fbyB-1in8A:undetectable | 1fbyB-1in8A:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jw0 | CEPHALOSPORINACYLASE ALPHA CHAIN (Brevundimonasdiminuta) |
PF01804(Penicil_amidase) | 6 | ILE A 111ALA A 115ALA A 113GLN A 116LEU A 130VAL A 137 | None | 1.37A | 1fbyB-1jw0A:undetectable | 1fbyB-1jw0A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1keh | PRECURSOR OFCEPHALOSPORINACYLASE (Brevundimonasdiminuta) |
PF01804(Penicil_amidase) | 6 | ILE A 111ALA A 115ALA A 113GLN A 116LEU A 130VAL A 137 | None | 1.39A | 1fbyB-1kehA:undetectable | 1fbyB-1kehA:16.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2w | MANNITOLDEHYDROGENASE (Pseudomonasfluorescens) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 5 | CYH A 170ALA A 172GLN A 175ALA A 120HIS A 215 | None | 1.03A | 1fbyB-1m2wA:undetectable | 1fbyB-1m2wA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE SMALLCHAIN (Oligotrophacarboxidovorans) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | ILE A 149ALA A 152ALA A 153LEU A 90ALA A 89 | None | 0.96A | 1fbyB-1n60A:undetectable | 1fbyB-1n60A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nmo | HYPOTHETICAL PROTEINYBGI (Escherichiacoli) |
PF01784(NIF3) | 5 | ILE A 179ALA A 182ALA A 183ALA A 169HIS A 201 | None | 0.84A | 1fbyB-1nmoA:undetectable | 1fbyB-1nmoA:22.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uhl | RETINOIC ACIDRECEPTOR RXR-BETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 339CYH A 340ALA A 342ALA A 343GLN A 346PHE A 384ARG A 387LEU A 397ALA A 398VAL A 413CYH A 503HIS A 506 | MEI A1001 (-3.8A)NoneMEI A1001 (-3.1A)MEI A1001 (-3.3A)NoneMEI A1001 (-4.5A)MEI A1001 (-3.6A)MEI A1001 ( 4.4A)MEI A1001 (-3.4A)MEI A1001 (-4.1A)MEI A1001 (-4.0A)None | 0.63A | 1fbyB-1uhlA:33.0 | 1fbyB-1uhlA:88.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xiu | RXR-LIKE PROTEIN (Biomphalariaglabrata) |
PF00104(Hormone_recep) | 12 | ILE A 242CYH A 243ALA A 245ALA A 246GLN A 249PHE A 287ARG A 290LEU A 300ALA A 301VAL A 316CYH A 406HIS A 409 | 9CR A 201 ( 4.4A)9CR A 201 ( 3.8A)9CR A 201 (-3.6A)9CR A 201 (-3.6A)9CR A 201 (-4.1A)9CR A 201 (-4.7A)9CR A 201 (-2.8A)9CR A 201 (-4.4A)9CR A 201 (-3.4A)9CR A 201 (-4.2A)9CR A 201 (-3.6A)9CR A 201 (-4.8A) | 0.31A | 1fbyB-1xiuA:31.3 | 1fbyB-1xiuA:80.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xls | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 268CYH A 269ALA A 271ALA A 272GLN A 275PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432HIS A 435 | 9CR A 801 (-3.9A)9CR A 801 ( 4.5A)9CR A 801 (-3.6A)9CR A 801 (-3.5A)9CR A 801 (-4.7A)9CR A 801 (-4.3A)9CR A 801 (-2.6A)9CR A 801 (-4.1A)9CR A 801 (-3.3A)9CR A 801 ( 4.3A)9CR A 801 ( 3.7A)None | 0.39A | 1fbyB-1xlsA:32.9 | 1fbyB-1xlsA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfm | FUMARASE (Saccharomycescerevisiae) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 5 | ILE A 391ALA A 176ALA A 177GLN A 180LEU A 70 | None | 1.03A | 1fbyB-1yfmA:undetectable | 1fbyB-1yfmA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z05 | TRANSCRIPTIONALREGULATOR, ROKFAMILY (Vibrio cholerae) |
PF00480(ROK) | 5 | ILE A 299CYH A 300ALA A 302ALA A 303LEU A 288 | None | 0.56A | 1fbyB-1z05A:undetectable | 1fbyB-1z05A:21.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z5x | ULTRASPIRACLEPROTEIN (USP) AHOMOLOGUE OF RXR (Bemisia tabaci) |
PF00104(Hormone_recep) | 6 | ILE U 303ALA U 306ALA U 307LEU U 365ALA U 362HIS U 373 | None | 1.35A | 1fbyB-1z5xU:21.8 | 1fbyB-1z5xU:62.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z5x | ULTRASPIRACLEPROTEIN (USP) AHOMOLOGUE OF RXR (Bemisia tabaci) |
PF00104(Hormone_recep) | 6 | ILE U 303CYH U 304ALA U 306ALA U 307LEU U 365ALA U 362 | None | 0.88A | 1fbyB-1z5xU:21.8 | 1fbyB-1z5xU:62.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z6r | MLC PROTEIN (Escherichiacoli) |
PF00480(ROK) | 5 | CYH A 301ALA A 303ALA A 304LEU A 290VAL A 271 | None | 0.91A | 1fbyB-1z6rA:undetectable | 1fbyB-1z6rA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zk7 | MERCURIC REDUCTASE (Pseudomonasaeruginosa) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 6 | ALA A 452ALA A 451GLN A 453LEU A 434ALA A 435VAL A 356 | NoneNoneGOL A3003 ( 3.8A)NoneNoneNone | 1.29A | 1fbyB-1zk7A:undetectable | 1fbyB-1zk7A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aa4 | PUTATIVEN-ACETYLMANNOSAMINEKINASE (Escherichiacoli) |
PF00480(ROK) | 5 | ILE A 183ALA A 186ALA A 187GLN A 188VAL A 243 | None | 1.06A | 1fbyB-2aa4A:undetectable | 1fbyB-2aa4A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bcc | UBIQUINOL CYTOCHROMEC OXIDOREDUCTASE (Gallus gallus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 6 | ILE A 116CYH A 120GLN A 72PHE A 64LEU A 75VAL A 39 | None | 1.46A | 1fbyB-2bccA:undetectable | 1fbyB-2bccA:19.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gl8 | RETINOIC ACIDRECEPTOR RXR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | PHE A 92ARG A 95LEU A 105ALA A 106VAL A 121CYH A 211 | None | 0.88A | 1fbyB-2gl8A:27.0 | 1fbyB-2gl8A:85.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iec | UNCHARACTERIZEDPROTEIN CONSERVED INARCHAEA (Methanopyruskandleri) |
PF04038(DHNA) | 5 | ILE A 49ALA A 52ALA A 53GLN A 56VAL A 66 | None | 1.08A | 1fbyB-2iecA:undetectable | 1fbyB-2iecA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jpe | NUCLEAR INHIBITOR OFPROTEIN PHOSPHATASE1 (Mus musculus) |
PF00498(FHA) | 5 | ILE A 86ALA A 72PHE A 14LEU A 88HIS A 77 | None | 1.05A | 1fbyB-2jpeA:undetectable | 1fbyB-2jpeA:21.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nxx | ULTRASPIRACLE (USP,NR2B4) (Triboliumcastaneum) |
PF00104(Hormone_recep) | 5 | PHE A 259ARG A 262LEU A 272ALA A 273CYH A 378 | None | 0.74A | 1fbyB-2nxxA:24.4 | 1fbyB-2nxxA:63.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oi2 | MEVALONATE KINASE (Streptococcuspneumoniae) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | ILE A 79ALA A 99ALA A 98LEU A 57ALA A 60 | None | 0.96A | 1fbyB-2oi2A:undetectable | 1fbyB-2oi2A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p6w | PUTATIVEGLYCOSYLTRANSFERASE(MANNOSYLTRANSFERASE) INVOLVED INGLYCOSYLATING THEPBCV-1 MAJOR CAPSIDPROTEIN (ParameciumbursariaChlorella virus1) |
PF05637(Glyco_transf_34) | 5 | ILE A 61ALA A 64ALA A 65LEU A 9VAL A 136 | None | 0.92A | 1fbyB-2p6wA:undetectable | 1fbyB-2p6wA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2e | TYPE 2 DNATOPOISOMERASE 6SUBUNIT B (Methanosarcinamazei) |
PF02518(HATPase_c)PF09239(Topo-VIb_trans) | 5 | ILE B 277CYH B 278ALA B 280ALA B 281PHE B 304 | None | 1.07A | 1fbyB-2q2eB:undetectable | 1fbyB-2q2eB:18.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q60 | RETINOID X RECEPTOR (Polyandrocarpamisakiensis) |
PF00104(Hormone_recep) | 5 | PHE A 188ARG A 191ALA A 202VAL A 217CYH A 307 | None | 0.81A | 1fbyB-2q60A:26.0 | 1fbyB-2q60A:72.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8w | POKEWEED ANTIVIRALPROTEIN (Phytolaccaacinosa) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 1.01A | 1fbyB-2q8wA:undetectable | 1fbyB-2q8wA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | ILE A 62ALA A 66ALA A 65LEU A 84ALA A 81 | None | 0.99A | 1fbyB-2xaxA:undetectable | 1fbyB-2xaxA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | ILE A 368ALA A 415ALA A 416LEU A 388ALA A 387 | None | 0.98A | 1fbyB-3afgA:undetectable | 1fbyB-3afgA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ALA A 104ALA A 102PHE A 31LEU A 28ALA A 29 | None | 1.06A | 1fbyB-3ce6A:undetectable | 1fbyB-3ce6A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cir | FUMARATE REDUCTASEIRON-SULFUR SUBUNIT (Escherichiacoli) |
PF13085(Fer2_3)PF13183(Fer4_8) | 5 | CYH B 154ALA B 156ALA B 157LEU B 93ALA B 94 | SF4 B 246 (-2.2A)NoneNoneNoneNone | 0.96A | 1fbyB-3cirB:undetectable | 1fbyB-3cirB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dme | CONSERVED EXPORTEDPROTEIN (Bordetellapertussis) |
PF01266(DAO) | 5 | ILE A 10ALA A 205ALA A 204LEU A 212ALA A 209 | FAD A 500 (-4.5A)FAD A 500 (-3.6A)NoneFAD A 500 ( 4.3A)None | 1.03A | 1fbyB-3dmeA:undetectable | 1fbyB-3dmeA:20.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 12 | ILE A 268CYH A 269ALA A 271ALA A 272GLN A 275PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432HIS A 435 | 9CR A7223 (-3.9A)None9CR A7223 (-3.5A)9CR A7223 (-4.2A)9CR A7223 (-4.6A)9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A)9CR A7223 ( 4.5A)9CR A7223 (-3.8A)9CR A7223 (-4.3A) | 0.72A | 1fbyB-3dzuA:32.4 | 1fbyB-3dzuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewb | 2-ISOPROPYLMALATESYNTHASE (Listeriamonocytogenes) |
PF00682(HMGL-like) | 6 | ILE X 167GLN X 181PHE X 183LEU X 186CYH X 202HIS X 201 | None | 1.32A | 1fbyB-3ewbX:undetectable | 1fbyB-3ewbX:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5k | RIBOSOME-INACTIVATING PROTEINPD-L1/PD-L2 (Phytolaccadioica) |
PF00161(RIP) | 5 | ILE A 214ALA A 217ARG A 240LEU A 222ALA A 221 | None | 0.99A | 1fbyB-3h5kA:undetectable | 1fbyB-3h5kA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50ALA A 51LEU B 20ALA B 19 | None | 0.64A | 1fbyB-3hveA:undetectable | 1fbyB-3hveA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50ALA B 51LEU A 20ALA A 19 | None | 0.69A | 1fbyB-3hveB:undetectable | 1fbyB-3hveB:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic5 | PUTATIVESACCHAROPINEDEHYDROGENASE (Ruegeriapomeroyi) |
PF03435(Sacchrp_dh_NADP) | 5 | ILE A 82ALA A 85ALA A 86LEU A 60ALA A 61 | None | 0.82A | 1fbyB-3ic5A:undetectable | 1fbyB-3ic5A:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ipc | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (AMINO ACID) (Agrobacteriumfabrum) |
PF13458(Peripla_BP_6) | 5 | ILE A 286ALA A 289ALA A 290LEU A 305ALA A 304 | None | 0.72A | 1fbyB-3ipcA:undetectable | 1fbyB-3ipcA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jbz | SERINE/THREONINE-PROTEIN KINASE MTOR (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08771(FRB_dom) | 5 | ILE A1994ALA A1991ALA A1990LEU A1976ALA A1979 | None | 1.05A | 1fbyB-3jbzA:undetectable | 1fbyB-3jbzA:12.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jru | PROBABLE CYTOSOLAMINOPEPTIDASE (Xanthomonasoryzae) |
no annotation | 5 | ALA B 139ALA B 138LEU B 3ALA B 2VAL B 21 | None | 1.07A | 1fbyB-3jruB:undetectable | 1fbyB-3jruB:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3keh | GLUCOCEREBROSIDASE (Homo sapiens) |
PF02055(Glyco_hydro_30)PF17189(Glyco_hydro_30C) | 5 | ALA A 89ALA A 90LEU A 383ALA A 384HIS A 162 | None | 1.02A | 1fbyB-3kehA:undetectable | 1fbyB-3kehA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktc | XYLOSE ISOMERASE (Pectobacteriumatrosepticum) |
PF01261(AP_endonuc_2) | 5 | ILE A 292ALA A 295LEU A 324ALA A 323VAL A 230 | None | 1.02A | 1fbyB-3ktcA:undetectable | 1fbyB-3ktcA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwg | HP0420 HOMOLOGUE (Helicobacterfelis) |
no annotation | 5 | ILE A 56ALA A 59ALA A 60LEU A 38ALA A 24 | None | 1.08A | 1fbyB-3lwgA:undetectable | 1fbyB-3lwgA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0m | HIT FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF01230(HIT) | 6 | ILE A 67ALA A 70ALA A 71LEU A 136ALA A 135HIS A 101 | NoneNoneNoneNoneNoneAMP A 155 (-3.8A) | 0.75A | 1fbyB-3o0mA:undetectable | 1fbyB-3o0mA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | ILE A 327ALA A 331ALA A 330LEU A 298ALA A 295 | None | 0.95A | 1fbyB-3oksA:undetectable | 1fbyB-3oksA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poy | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 6 | ILE A 965GLN A 955PHE A 956LEU A1076ALA A1077HIS A 986 | None | 1.18A | 1fbyB-3poyA:undetectable | 1fbyB-3poyA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qcw | NEUREXIN-1-ALPHA (Bos taurus) |
PF00008(EGF)PF02210(Laminin_G_2) | 6 | ILE A 949GLN A 939PHE A 940LEU A1060ALA A1061HIS A 970 | None | 1.20A | 1fbyB-3qcwA:undetectable | 1fbyB-3qcwA:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s1s | RESTRICTIONENDONUCLEASE BPUSI (Bacilluspumilus) |
PF02384(N6_Mtase)PF15516(BpuSI_N) | 5 | ILE A 28CYH A 29ALA A 31ALA A 32GLN A 35 | None | 0.84A | 1fbyB-3s1sA:undetectable | 1fbyB-3s1sA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sim | PROTEIN, FAMILY 18CHITINASE (Crocus vernus) |
PF00704(Glyco_hydro_18) | 5 | ILE A 141CYH A 140ALA A 138LEU A 172ALA A 171 | None | 1.04A | 1fbyB-3simA:undetectable | 1fbyB-3simA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc2 | HYPOTHETICAL PROTEINWITHIMMUNOGLOBULIN-LIKEFOLD (Pseudomonasaeruginosa) |
PF14467(DUF4426) | 5 | ILE A 59ALA A 103GLN A 104PHE A 105LEU A 88 | None | 1.01A | 1fbyB-3uc2A:undetectable | 1fbyB-3uc2A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut2 | CATALASE-PEROXIDASE2 (Magnaportheoryzae) |
PF00141(peroxidase) | 5 | ILE A 505ALA A 593ALA A 592LEU A 516ALA A 517 | None | 1.05A | 1fbyB-3ut2A:undetectable | 1fbyB-3ut2A:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuy | NITRILASE (Synechocystissp. PCC 6803) |
PF00795(CN_hydrolase) | 5 | ILE A 93ALA A 96ALA A 97LEU A 35VAL A 108 | None | 1.08A | 1fbyB-3wuyA:undetectable | 1fbyB-3wuyA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxw | ADIPONECTIN RECEPTORPROTEIN 2 (Homo sapiens) |
PF03006(HlyIII) | 5 | ILE A 322ALA A 325ALA A 326LEU A 283ALA A 279 | None | 0.71A | 1fbyB-3wxwA:undetectable | 1fbyB-3wxwA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8b | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1 (Saccharomycescerevisiae) |
PF16417(CNOT1_TTP_bind)PF16418(CNOT1_HEAT)PF16419(CNOT1_HEAT_N) | 6 | ILE A 741ALA A 744ALA A 745LEU A 714ALA A 715VAL A 728 | None | 1.14A | 1fbyB-4b8bA:undetectable | 1fbyB-4b8bA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwr | PROTEINCORRESPONDING TOLOCUS C5321 FROMCFT073 E.COLI STRAIN (Escherichiacoli) |
PF08238(Sel1) | 5 | ALA A 46ALA A 47GLN A 49LEU A 20ALA A 16 | None | 1.03A | 1fbyB-4bwrA:undetectable | 1fbyB-4bwrA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccs | CBIX (Paracoccuspantotrophus) |
PF01903(CbiX) | 5 | ILE A 106ALA A 109ALA A 110GLN A 113LEU A 206 | None | 0.80A | 1fbyB-4ccsA:undetectable | 1fbyB-4ccsA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhg | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Thermobisporabispora) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 6 | ILE A 288ALA A 303ALA A 300LEU A 313ALA A 337HIS A 291 | None | 1.30A | 1fbyB-4dhgA:undetectable | 1fbyB-4dhgA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1k | TRIOSEPHOSPHATEISOMERASE (Burkholderiathailandensis) |
PF00121(TIM) | 5 | ILE A 246CYH A 247ALA A 249ALA A 250ALA A 220 | None | 0.85A | 1fbyB-4g1kA:undetectable | 1fbyB-4g1kA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i59 | CYCLOHEXYLAMINEOXIDASE (Microbacteriumoxydans) |
PF01593(Amino_oxidase) | 5 | ALA A 471ALA A 470LEU A 50ALA A 49VAL A 273 | None | 0.96A | 1fbyB-4i59A:undetectable | 1fbyB-4i59A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia4 | AQUAPORIN (Spinaciaoleracea) |
PF00230(MIP) | 5 | ALA A 257ALA A 258GLN A 261LEU A 110ALA A 111 | None | 0.83A | 1fbyB-4ia4A:undetectable | 1fbyB-4ia4A:22.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 12 | ILE D 268CYH D 269ALA D 271ALA D 272GLN D 275PHE D 313ARG D 316LEU D 326ALA D 327VAL D 342CYH D 432HIS D 435 | None | 0.59A | 1fbyB-4j5xD:31.5 | 1fbyB-4j5xD:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lom | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Mycobacteriumtuberculosis) |
PF00475(IGPD) | 5 | ALA A 86GLN A 89LEU A 28ALA A 13VAL A 186 | None | 0.97A | 1fbyB-4lomA:undetectable | 1fbyB-4lomA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nn1 | TRANSCRIPTIONALREGULATOR (Mycobacteriumtuberculosis) |
PF00440(TetR_N) | 5 | ILE A 12ALA A 15ALA A 16GLN A 19ALA A 35 | None | 0.54A | 1fbyB-4nn1A:undetectable | 1fbyB-4nn1A:26.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oby | ARGININE--TRNALIGASE (Escherichiacoli) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 5 | ILE A 138ALA A 141ALA A 142LEU A 434HIS A 366 | None | 1.07A | 1fbyB-4obyA:undetectable | 1fbyB-4obyA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p47 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Ochrobactrumanthropi) |
PF03480(DctP) | 5 | ILE A 260ALA A 264ALA A 263LEU A 144ALA A 145 | None | 1.00A | 1fbyB-4p47A:undetectable | 1fbyB-4p47A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rp8 | ASCORBATE-SPECIFICPERMEASE IICCOMPONENT ULAA (Escherichiacoli) |
PF03611(EIIC-GAT) | 5 | ILE A 160CYH A 161ALA A 163LEU A 110ALA A 111 | None | 0.93A | 1fbyB-4rp8A:undetectable | 1fbyB-4rp8A:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rrj | PROBABLETHREONINE--TRNALIGASE 2 (Aeropyrumpernix) |
PF08915(tRNA-Thr_ED) | 5 | ILE A 58ALA A 55ALA A 54LEU A 99ALA A 98 | None | 0.98A | 1fbyB-4rrjA:undetectable | 1fbyB-4rrjA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsb | POLYMERASE PB2 (Influenza Avirus) |
PF00604(Flu_PB2) | 5 | ILE C 310CYH C 311ALA C 313ALA C 314VAL C 518 | NoneNoneNoneNonePO4 C 801 ( 4.1A) | 0.99A | 1fbyB-4wsbC:undetectable | 1fbyB-4wsbC:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9n | L-ALPHA-GLYCEROPHOSPHATE OXIDASE (Mycoplasmapneumoniae) |
PF01266(DAO) | 5 | ALA A 209ALA A 208LEU A 216ALA A 213VAL A 202 | FAD A 401 (-3.6A)NoneNoneNoneNone | 0.88A | 1fbyB-4x9nA:undetectable | 1fbyB-4x9nA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xai | GRUNGE, ISOFORM JMALTOSE-BINDINGPERIPLASMICPROTEIN,TAILLESSORTHOLOG (Drosophilamelanogaster;Escherichiacoli;Triboliumcastaneum) |
PF00104(Hormone_recep)PF13416(SBP_bac_8)no annotation | 5 | ALA A1204ALA A1203GLN A1205LEU P1820ALA P1819 | None | 0.87A | 1fbyB-4xaiA:15.5 | 1fbyB-4xaiA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xb3 | GLUCAN1,6-ALPHA-GLUCOSIDASE (Streptococcusmutans) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | ALA A 224ALA A 223GLN A 228PHE A 226HIS A 215 | None | 1.05A | 1fbyB-4xb3A:undetectable | 1fbyB-4xb3A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 5 | ALA A 53ALA A 22LEU A 49ALA A 50VAL A 40 | None | 1.05A | 1fbyB-4xboA:undetectable | 1fbyB-4xboA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ILE A 211ALA A 214ALA A 215LEU A 183ALA A 184 | None | 0.71A | 1fbyB-4xgjA:undetectable | 1fbyB-4xgjA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yk2 | BARTONELLA EFFECTORPROTEIN (BEP)SUBSTRATE OF VIRBT4SS (Bartonellaclarridgeiae) |
no annotation | 5 | ILE A 160ALA A 156PHE A 103LEU A 140ALA A 141 | None | 0.96A | 1fbyB-4yk2A:undetectable | 1fbyB-4yk2A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEFAD-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | ILE B 236ALA B 239ALA B 240LEU B 226ALA B 222 | None | 1.00A | 1fbyB-4zohB:undetectable | 1fbyB-4zohB:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp1 | MYCOCEROSIC ACIDSYNTHASE (Mycolicibacteriumsmegmatis) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 6 | ILE A 185ALA A 188LEU A 250ALA A 200VAL A 412HIS A 423 | None | 1.49A | 1fbyB-5bp1A:undetectable | 1fbyB-5bp1A:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5daj | NALD (Pseudomonasaeruginosa) |
PF00440(TetR_N)PF08361(TetR_C_2) | 5 | ILE A 15ALA A 18ALA A 19ALA A 39HIS A 56 | None | 0.99A | 1fbyB-5dajA:undetectable | 1fbyB-5dajA:24.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e76 | SUSD-LIKE PROTEINBACOVA_02651 (Bacteroidesovatus) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 5 | ILE A 213ALA A 210ALA A 209LEU A 189ALA A 192 | None | 1.06A | 1fbyB-5e76A:undetectable | 1fbyB-5e76A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fuk | MROUPO (Marasmiusrotula) |
PF01328(Peroxidase_2) | 5 | ILE A 123ALA A 127ALA A 126GLN A 128LEU A 217 | NAG A1240 ( 4.5A)NoneNoneNoneNone | 1.05A | 1fbyB-5fukA:undetectable | 1fbyB-5fukA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kr6 | 4-AMINOBUTYRATETRANSAMINASE (Pseudomonas) |
PF00202(Aminotran_3) | 5 | ILE A 331CYH A 332ALA A 334ALA A 335ALA A 73 | None | 1.08A | 1fbyB-5kr6A:undetectable | 1fbyB-5kr6A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6m | RIBONUCLEASE VAPC (Caulobactervibrioides) |
PF01850(PIN) | 5 | ILE B 82ALA B 100ALA B 99GLN B 101ALA B 75 | None | 1.08A | 1fbyB-5l6mB:undetectable | 1fbyB-5l6mB:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9p | PERIPLASMIC BINDINGPROTEIN (Agrobacteriumtumefaciens) |
PF13416(SBP_bac_8) | 5 | ILE A 172ALA A 175ALA A 176LEU A 203HIS A 339 | None | 1.04A | 1fbyB-5l9pA:undetectable | 1fbyB-5l9pA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5maw | FLAGELLAR PROTEINFLIS (Bacillussubtilis) |
no annotation | 5 | ILE E 35ALA E 38ALA E 39LEU E 54VAL E 108 | None | 1.03A | 1fbyB-5mawE:undetectable | 1fbyB-5mawE:26.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzy | GLUTACONATECOA-TRANSFERASEFAMILY, SUBUNIT A (Myxococcusxanthus) |
PF01144(CoA_trans) | 5 | ALA A 189ALA A 190PHE A 157LEU A 113ALA A 116 | None | 0.89A | 1fbyB-5mzyA:undetectable | 1fbyB-5mzyA:24.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0g | PRECORRIN-8XMETHYLMUTASE (Rhodobactercapsulatus) |
no annotation | 6 | ILE A 73ALA A 71ALA A 130LEU A 67ALA A 66VAL A 80 | None | 1.21A | 1fbyB-5n0gA:undetectable | 1fbyB-5n0gA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohs | - (-) |
no annotation | 5 | ILE A 257ALA A 260PHE A 541LEU A 538ALA A 539 | None | 0.86A | 1fbyB-5ohsA:undetectable | 1fbyB-5ohsA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
no annotation | 11 | ILE A 268CYH A 269ALA A 271ALA A 272GLN A 275PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432 | 9CR A 503 (-4.0A)9CR A 503 ( 4.4A)9CR A 503 (-3.5A)9CR A 503 (-3.5A)9CR A 503 (-3.8A)9CR A 503 (-4.7A)9CR A 503 (-3.0A)9CR A 503 (-4.3A)9CR A 503 (-3.4A)None9CR A 503 (-3.3A) | 0.60A | 1fbyB-5uanA:32.4 | 1fbyB-5uanA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
no annotation | 11 | ILE A 268CYH A 269ALA A 271ALA A 272GLN A 275PHE A 313LEU A 326ALA A 327VAL A 342CYH A 432HIS A 435 | 9CR A 503 (-4.0A)9CR A 503 ( 4.4A)9CR A 503 (-3.5A)9CR A 503 (-3.5A)9CR A 503 (-3.8A)9CR A 503 (-4.7A)9CR A 503 (-4.3A)9CR A 503 (-3.4A)None9CR A 503 (-3.3A)None | 0.51A | 1fbyB-5uanA:32.4 | 1fbyB-5uanA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 5 | ILE T 68ALA T 65ALA T 64LEU T 25ALA T 26 | None | 0.97A | 1fbyB-5xyiT:undetectable | 1fbyB-5xyiT:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6co9 | PROBABLECOA-TRANSFERASEALPHA SUBUNIT (Rhodococcusjostii) |
no annotation | 5 | CYH A 195ALA A 197ALA A 198LEU A 112ALA A 115 | None | 1.02A | 1fbyB-6co9A:undetectable | 1fbyB-6co9A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d95 | - (-) |
no annotation | 5 | ILE A 129ALA A 132ALA A 133LEU A 267ALA A 266 | None | 0.58A | 1fbyB-6d95A:undetectable | 1fbyB-6d95A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6euv | POLYMERASE BASICPROTEIN 2 (Influenza Avirus) |
no annotation | 5 | ILE A 310CYH A 311ALA A 313ALA A 314VAL A 518 | None | 0.97A | 1fbyB-6euvA:undetectable | 1fbyB-6euvA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ezm | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Saccharomycescerevisiae) |
no annotation | 5 | ALA U 131PHE U 193LEU U 196ALA U 195HIS U 162 | NoneNoneNoneNone MN U 301 (-3.2A) | 1.06A | 1fbyB-6ezmU:undetectable | 1fbyB-6ezmU:16.96 |