SIMILAR PATTERNS OF AMINO ACIDS FOR 1FBY_A_9CRA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi)
PF00544
(Pec_lyase_C)
5 ILE A  33
ALA A  36
ALA A  35
ALA A  49
VAL A  82
None
0.97A 1fbyA-1airA:
undetectable
1fbyA-1airA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans)
PF00463
(ICL)
5 ILE A 166
ALA A 192
ALA A 191
LEU A  59
ALA A  56
None
0.96A 1fbyA-1dquA:
undetectable
1fbyA-1dquA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus)
PF00696
(AA_kinase)
5 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
None
0.80A 1fbyA-1e19A:
undetectable
1fbyA-1e19A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE


(Equus caballus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 CYH A 210
ALA A 213
ALA A 215
GLN A 190
VAL A 289
None
1.04A 1fbyA-1ee2A:
undetectable
1fbyA-1ee2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
None
0.99A 1fbyA-1fc4A:
undetectable
1fbyA-1fc4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Escherichia
coli)
PF01182
(Glucosamine_iso)
5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
None
1.08A 1fbyA-1fs5A:
undetectable
1fbyA-1fs5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
5 ILE A 435
CYH A 347
ALA A 351
ALA A 348
ALA A 356
None
1.07A 1fbyA-1h7wA:
undetectable
1fbyA-1h7wA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE


(Escherichia
coli)
PF00633
(HHH)
PF00730
(HhH-GPD)
5 ALA A  93
ALA A  92
GLN A  94
LEU A  65
ALA A  66
None
1.09A 1fbyA-1kqjA:
undetectable
1fbyA-1kqjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE


(Pseudomonas
fluorescens)
PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C)
5 CYH A 170
ALA A 172
GLN A 175
ALA A 120
HIS A 215
None
1.03A 1fbyA-1m2wA:
undetectable
1fbyA-1m2wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN


(Oligotropha
carboxidovorans)
PF00111
(Fer2)
PF01799
(Fer2_2)
5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
None
0.95A 1fbyA-1n60A:
undetectable
1fbyA-1n60A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI


(Escherichia
coli)
PF01784
(NIF3)
5 ILE A 179
ALA A 182
ALA A 183
ALA A 169
HIS A 201
None
0.84A 1fbyA-1nmoA:
undetectable
1fbyA-1nmoA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 339
CYH A 340
ALA A 342
ALA A 343
GLN A 346
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
HIS A 506
MEI  A1001 (-3.8A)
None
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
None
0.66A 1fbyA-1uhlA:
33.3
1fbyA-1uhlA:
88.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata)
PF00104
(Hormone_recep)
12 ILE A 242
CYH A 243
ALA A 245
ALA A 246
GLN A 249
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
HIS A 409
9CR  A 201 ( 4.4A)
9CR  A 201 ( 3.8A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.8A)
0.33A 1fbyA-1xiuA:
31.8
1fbyA-1xiuA:
80.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
HIS A 435
9CR  A 801 (-3.9A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
None
0.41A 1fbyA-1xlsA:
33.7
1fbyA-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae)
PF00206
(Lyase_1)
PF10415
(FumaraseC_C)
5 ILE A 391
ALA A 176
ALA A 177
GLN A 180
LEU A  70
None
1.05A 1fbyA-1yfmA:
2.3
1fbyA-1yfmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY


(Vibrio cholerae)
PF00480
(ROK)
5 ILE A 299
CYH A 300
ALA A 302
ALA A 303
LEU A 288
None
0.57A 1fbyA-1z05A:
undetectable
1fbyA-1z05A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR


(Bemisia tabaci)
PF00104
(Hormone_recep)
5 CYH U 304
ALA U 306
ALA U 307
GLN U 310
ALA U 362
None
1.08A 1fbyA-1z5xU:
21.6
1fbyA-1z5xU:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR


(Bemisia tabaci)
PF00104
(Hormone_recep)
6 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
HIS U 373
None
1.35A 1fbyA-1z5xU:
21.6
1fbyA-1z5xU:
62.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR


(Bemisia tabaci)
PF00104
(Hormone_recep)
6 ILE U 303
CYH U 304
ALA U 306
ALA U 307
LEU U 365
ALA U 362
None
0.89A 1fbyA-1z5xU:
21.6
1fbyA-1z5xU:
62.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli)
PF00480
(ROK)
5 CYH A 301
ALA A 303
ALA A 304
LEU A 290
VAL A 271
None
0.89A 1fbyA-1z6rA:
undetectable
1fbyA-1z6rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
6 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
None
None
GOL  A3003 ( 3.8A)
None
None
None
1.30A 1fbyA-1zk7A:
undetectable
1fbyA-1zk7A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE


(Escherichia
coli)
PF00480
(ROK)
5 ILE A 183
ALA A 186
ALA A 187
GLN A 188
VAL A 243
None
1.05A 1fbyA-2aa4A:
undetectable
1fbyA-2aa4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE


(Gallus gallus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
6 ILE A 116
CYH A 120
GLN A  72
PHE A  64
LEU A  75
VAL A  39
None
1.43A 1fbyA-2bccA:
undetectable
1fbyA-2bccA:
19.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
None
0.86A 1fbyA-2gl8A:
27.5
1fbyA-2gl8A:
85.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpe NUCLEAR INHIBITOR OF
PROTEIN PHOSPHATASE
1


(Mus musculus)
PF00498
(FHA)
5 ILE A  86
ALA A  72
PHE A  14
LEU A  88
HIS A  77
None
1.05A 1fbyA-2jpeA:
undetectable
1fbyA-2jpeA:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
None
0.73A 1fbyA-2nxxA:
24.9
1fbyA-2nxxA:
63.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
None
0.97A 1fbyA-2oi2A:
undetectable
1fbyA-2oi2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN


(Paramecium
bursaria
Chlorella virus
1)
PF05637
(Glyco_transf_34)
5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
VAL A 136
None
0.93A 1fbyA-2p6wA:
undetectable
1fbyA-2p6wA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B


(Methanosarcina
mazei)
PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans)
5 ILE B 277
CYH B 278
ALA B 280
ALA B 281
PHE B 304
None
1.08A 1fbyA-2q2eB:
undetectable
1fbyA-2q2eB:
18.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis)
PF00104
(Hormone_recep)
5 PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
None
0.81A 1fbyA-2q60A:
27.1
1fbyA-2q60A:
72.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
1.01A 1fbyA-2q8wA:
undetectable
1fbyA-2q8wA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1


(Zea mays)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
5 ILE A 315
ALA A 313
LEU A 301
ALA A 302
VAL A 360
None
1.04A 1fbyA-2qpmA:
undetectable
1fbyA-2qpmA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1


(Homo sapiens)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
5 ALA A 146
ALA A 145
LEU A 186
ALA A 345
VAL A 357
None
1.08A 1fbyA-2vn8A:
undetectable
1fbyA-2vn8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
None
1.01A 1fbyA-2xaxA:
undetectable
1fbyA-2xaxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
PF04151
(PPC)
5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
None
0.99A 1fbyA-3afgA:
undetectable
1fbyA-3afgA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus)
PF02210
(Laminin_G_2)
6 ILE A 905
GLN A 895
PHE A 896
LEU A1016
ALA A1017
HIS A 926
None
1.24A 1fbyA-3asiA:
undetectable
1fbyA-3asiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE


(Mycobacterium
tuberculosis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ALA A 104
ALA A 102
PHE A  31
LEU A  28
ALA A  29
None
1.08A 1fbyA-3ce6A:
undetectable
1fbyA-3ce6A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT


(Escherichia
coli)
PF13085
(Fer2_3)
PF13183
(Fer4_8)
5 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
SF4  B 246 (-2.2A)
None
None
None
None
0.96A 1fbyA-3cirB:
undetectable
1fbyA-3cirB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN


(Bordetella
pertussis)
PF01266
(DAO)
5 ILE A  10
ALA A 205
ALA A 204
LEU A 212
ALA A 209
FAD  A 500 (-4.5A)
FAD  A 500 (-3.6A)
None
FAD  A 500 ( 4.3A)
None
1.04A 1fbyA-3dmeA:
undetectable
1fbyA-3dmeA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
HIS A 435
9CR  A7223 (-3.9A)
None
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 (-4.3A)
0.71A 1fbyA-3dzuA:
33.1
1fbyA-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE


(Listeria
monocytogenes)
PF00682
(HMGL-like)
6 ILE X 167
GLN X 181
PHE X 183
LEU X 186
CYH X 202
HIS X 201
None
1.32A 1fbyA-3ewbX:
undetectable
1fbyA-3ewbX:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2


(Phytolacca
dioica)
PF00161
(RIP)
5 ILE A 214
ALA A 217
ARG A 240
LEU A 222
ALA A 221
None
1.00A 1fbyA-3h5kA:
undetectable
1fbyA-3h5kA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
None
0.64A 1fbyA-3hveA:
undetectable
1fbyA-3hveA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens)
PF00651
(BTB)
PF07707
(BACK)
5 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
None
0.70A 1fbyA-3hveB:
undetectable
1fbyA-3hveB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE


(Ruegeria
pomeroyi)
PF03435
(Sacchrp_dh_NADP)
5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
None
0.82A 1fbyA-3ic5A:
undetectable
1fbyA-3ic5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)


(Agrobacterium
fabrum)
PF13458
(Peripla_BP_6)
5 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
None
0.71A 1fbyA-3ipcA:
undetectable
1fbyA-3ipcA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
5 ILE A1994
ALA A1991
ALA A1990
LEU A1976
ALA A1979
None
1.06A 1fbyA-3jbzA:
undetectable
1fbyA-3jbzA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE


(Xanthomonas
oryzae)
no annotation 5 ALA B 139
ALA B 138
LEU B   3
ALA B   2
VAL B  21
None
1.08A 1fbyA-3jruB:
undetectable
1fbyA-3jruB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
5 ALA A  89
ALA A  90
LEU A 383
ALA A 384
HIS A 162
None
1.03A 1fbyA-3kehA:
undetectable
1fbyA-3kehA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum)
PF01261
(AP_endonuc_2)
5 ILE A 292
ALA A 295
LEU A 324
ALA A 323
VAL A 230
None
1.02A 1fbyA-3ktcA:
undetectable
1fbyA-3ktcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwg HP0420 HOMOLOGUE

(Helicobacter
felis)
no annotation 5 ILE A  56
ALA A  59
ALA A  60
LEU A  38
ALA A  24
None
1.07A 1fbyA-3lwgA:
undetectable
1fbyA-3lwgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01230
(HIT)
6 ILE A  67
ALA A  70
ALA A  71
LEU A 136
ALA A 135
HIS A 101
None
None
None
None
None
AMP  A 155 (-3.8A)
0.76A 1fbyA-3o0mA:
undetectable
1fbyA-3o0mA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
None
0.95A 1fbyA-3oksA:
undetectable
1fbyA-3oksA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
6 ILE A 965
GLN A 955
PHE A 956
LEU A1076
ALA A1077
HIS A 986
None
1.18A 1fbyA-3poyA:
undetectable
1fbyA-3poyA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
6 ILE A 949
GLN A 939
PHE A 940
LEU A1060
ALA A1061
HIS A 970
None
1.20A 1fbyA-3qcwA:
undetectable
1fbyA-3qcwA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE


(Crocus vernus)
PF00704
(Glyco_hydro_18)
5 ILE A 141
CYH A 140
ALA A 138
LEU A 172
ALA A 171
None
1.04A 1fbyA-3simA:
undetectable
1fbyA-3simA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD


(Pseudomonas
aeruginosa)
PF14467
(DUF4426)
5 ILE A  59
ALA A 103
GLN A 104
PHE A 105
LEU A  88
None
1.01A 1fbyA-3uc2A:
undetectable
1fbyA-3uc2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2


(Magnaporthe
oryzae)
PF00141
(peroxidase)
5 ILE A 505
ALA A 593
ALA A 592
LEU A 516
ALA A 517
None
1.05A 1fbyA-3ut2A:
undetectable
1fbyA-3ut2A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuy NITRILASE

(Synechocystis
sp. PCC 6803)
PF00795
(CN_hydrolase)
5 ILE A  93
ALA A  96
ALA A  97
LEU A  35
VAL A 108
None
1.07A 1fbyA-3wuyA:
undetectable
1fbyA-3wuyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2


(Homo sapiens)
PF03006
(HlyIII)
5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
None
0.69A 1fbyA-3wxwA:
undetectable
1fbyA-3wxwA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori)
PF00696
(AA_kinase)
5 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
None
0.90A 1fbyA-4a7wA:
undetectable
1fbyA-4a7wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N)
6 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
None
1.17A 1fbyA-4b8bA:
undetectable
1fbyA-4b8bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwr PROTEIN
CORRESPONDING TO
LOCUS C5321 FROM
CFT073 E.COLI STRAIN


(Escherichia
coli)
PF08238
(Sel1)
5 ALA A  46
ALA A  47
GLN A  49
LEU A  20
ALA A  16
None
1.05A 1fbyA-4bwrA:
undetectable
1fbyA-4bwrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Thermobispora
bispora)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
6 ILE A 288
ALA A 303
ALA A 300
LEU A 313
ALA A 337
HIS A 291
None
1.29A 1fbyA-4dhgA:
undetectable
1fbyA-4dhgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1k TRIOSEPHOSPHATE
ISOMERASE


(Burkholderia
thailandensis)
PF00121
(TIM)
5 ILE A 246
CYH A 247
ALA A 249
ALA A 250
ALA A 220
None
0.87A 1fbyA-4g1kA:
undetectable
1fbyA-4g1kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE


(Microbacterium
oxydans)
PF01593
(Amino_oxidase)
5 ALA A 471
ALA A 470
LEU A  50
ALA A  49
VAL A 273
None
0.96A 1fbyA-4i59A:
undetectable
1fbyA-4i59A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea)
PF00230
(MIP)
5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
None
0.83A 1fbyA-4ia4A:
undetectable
1fbyA-4ia4A:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 12 ILE D 268
CYH D 269
ALA D 271
ALA D 272
GLN D 275
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
HIS D 435
None
0.61A 1fbyA-4j5xD:
32.2
1fbyA-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Mycobacterium
tuberculosis)
PF00475
(IGPD)
5 ALA A  86
GLN A  89
LEU A  28
ALA A  13
VAL A 186
None
0.96A 1fbyA-4lomA:
undetectable
1fbyA-4lomA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Polaromonas sp.
JS666)
PF03480
(DctP)
5 ILE A 261
ALA A 265
ALA A 264
LEU A 146
ALA A 147
None
1.08A 1fbyA-4mijA:
undetectable
1fbyA-4mijA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00440
(TetR_N)
5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
None
0.55A 1fbyA-4nn1A:
undetectable
1fbyA-4nn1A:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Ochrobactrum
anthropi)
PF03480
(DctP)
5 ILE A 260
ALA A 264
ALA A 263
LEU A 144
ALA A 145
None
1.01A 1fbyA-4p47A:
undetectable
1fbyA-4p47A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA


(Escherichia
coli)
PF03611
(EIIC-GAT)
5 ILE A 160
CYH A 161
ALA A 163
LEU A 110
ALA A 111
None
0.94A 1fbyA-4rp8A:
undetectable
1fbyA-4rp8A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2


(Aeropyrum
pernix)
PF08915
(tRNA-Thr_ED)
5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
None
0.99A 1fbyA-4rrjA:
undetectable
1fbyA-4rrjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE


(Mycoplasma
pneumoniae)
PF01266
(DAO)
5 ALA A 209
ALA A 208
LEU A 216
ALA A 213
VAL A 202
FAD  A 401 (-3.6A)
None
None
None
None
0.91A 1fbyA-4x9nA:
undetectable
1fbyA-4x9nA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai GRUNGE, ISOFORM J
MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG


(Drosophila
melanogaster;
Escherichia
coli;
Tribolium
castaneum)
PF00104
(Hormone_recep)
PF13416
(SBP_bac_8)
no annotation
5 ALA A1204
ALA A1203
GLN A1205
LEU P1820
ALA P1819
None
0.89A 1fbyA-4xaiA:
14.5
1fbyA-4xaiA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E


(Streptococcus
mutans)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
5 ALA A 224
ALA A 223
GLN A 228
PHE A 226
HIS A 215
None
1.06A 1fbyA-4xb3A:
undetectable
1fbyA-4xb3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ


(Escherichia
coli)
PF00588
(SpoU_methylase)
5 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
None
1.09A 1fbyA-4xboA:
undetectable
1fbyA-4xboA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
None
0.72A 1fbyA-4xgjA:
undetectable
1fbyA-4xgjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS


(Bartonella
clarridgeiae)
no annotation 5 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
None
0.95A 1fbyA-4yk2A:
undetectable
1fbyA-4yk2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT


(Sulfurisphaera
tokodaii)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
5 ILE B 236
ALA B 239
ALA B 240
LEU B 226
ALA B 222
None
1.00A 1fbyA-4zohB:
undetectable
1fbyA-4zohB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE


(Mycolicibacterium
smegmatis)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
6 ILE A 185
ALA A 188
LEU A 250
ALA A 200
VAL A 412
HIS A 423
None
1.50A 1fbyA-5bp1A:
undetectable
1fbyA-5bp1A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
5 ILE A  15
ALA A  18
ALA A  19
ALA A  39
HIS A  56
None
1.01A 1fbyA-5dajA:
undetectable
1fbyA-5dajA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651


(Bacteroides
ovatus)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 ILE A 213
ALA A 210
ALA A 209
LEU A 189
ALA A 192
None
1.07A 1fbyA-5e76A:
undetectable
1fbyA-5e76A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE


(Campylobacter
jejuni)
PF00701
(DHDPS)
5 ALA A  81
ALA A  79
PHE A  95
LEU A  92
ALA A  93
None
1.10A 1fbyA-5f1uA:
undetectable
1fbyA-5f1uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuk MROUPO

(Marasmius
rotula)
PF01328
(Peroxidase_2)
5 ILE A 123
ALA A 127
ALA A 126
GLN A 128
LEU A 217
NAG  A1240 ( 4.5A)
None
None
None
None
1.05A 1fbyA-5fukA:
undetectable
1fbyA-5fukA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Vibrio cholerae)
PF01182
(Glucosamine_iso)
5 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
None
1.06A 1fbyA-5hj5A:
undetectable
1fbyA-5hj5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE


(Pseudomonas)
PF00202
(Aminotran_3)
5 ILE A 331
CYH A 332
ALA A 334
ALA A 335
ALA A  73
None
1.08A 1fbyA-5kr6A:
undetectable
1fbyA-5kr6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6m RIBONUCLEASE VAPC

(Caulobacter
vibrioides)
PF01850
(PIN)
5 ILE B  82
ALA B 100
ALA B  99
GLN B 101
ALA B  75
None
1.07A 1fbyA-5l6mB:
undetectable
1fbyA-5l6mB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9p PERIPLASMIC BINDING
PROTEIN


(Agrobacterium
tumefaciens)
PF13416
(SBP_bac_8)
5 ILE A 172
ALA A 175
ALA A 176
LEU A 203
HIS A 339
None
1.03A 1fbyA-5l9pA:
undetectable
1fbyA-5l9pA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5maw FLAGELLAR PROTEIN
FLIS


(Bacillus
subtilis)
no annotation 5 ILE E  35
ALA E  38
ALA E  39
LEU E  54
VAL E 108
None
1.04A 1fbyA-5mawE:
undetectable
1fbyA-5mawE:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A


(Myxococcus
xanthus)
PF01144
(CoA_trans)
5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
None
0.91A 1fbyA-5mzyA:
undetectable
1fbyA-5mzyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE


(Rhodobacter
capsulatus)
no annotation 6 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
VAL A  80
None
1.25A 1fbyA-5n0gA:
undetectable
1fbyA-5n0gA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
None
0.86A 1fbyA-5ohsA:
undetectable
1fbyA-5ohsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 11 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
0.60A 1fbyA-5uanA:
33.3
1fbyA-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
no annotation 11 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
LEU A 326
ALA A 327
VAL A 342
CYH A 432
HIS A 435
9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
0.52A 1fbyA-5uanA:
33.3
1fbyA-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE


(Trichomonas
vaginalis)
PF01090
(Ribosomal_S19e)
5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
None
0.96A 1fbyA-5xyiT:
undetectable
1fbyA-5xyiT:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE


(Saccharomyces
cerevisiae)
no annotation 5 ILE A  39
ALA A 315
ALA A  41
PHE A 294
ALA A 293
None
1.09A 1fbyA-6c2hA:
undetectable
1fbyA-6c2hA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-)
no annotation 5 ILE A 129
ALA A 132
ALA A 133
LEU A 267
ALA A 266
None
0.60A 1fbyA-6d95A:
undetectable
1fbyA-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE


(Saccharomyces
cerevisiae)
no annotation 5 ALA U 131
PHE U 193
LEU U 196
ALA U 195
HIS U 162
None
None
None
None
MN  U 301 (-3.2A)
1.08A 1fbyA-6ezmU:
undetectable
1fbyA-6ezmU:
16.96