SIMILAR PATTERNS OF AMINO ACIDS FOR 1FBM_B_RTLB951_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE


(Plasmodium
falciparum)
PF00274
(Glycolytic)
4 THR A 212
LEU A 216
VAL A 219
LEU A 223
None
0.63A 1fbmB-1a5cA:
undetectable
1fbmB-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 THR A 178
LEU A 179
VAL A  28
LEU A   5
None
1.07A 1fbmB-1biiA:
undetectable
1fbmB-1biiA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE


(Drosophila
melanogaster)
PF00274
(Glycolytic)
4 THR A 205
LEU A 209
VAL A 212
LEU A 216
None
0.44A 1fbmB-1fbaA:
undetectable
1fbmB-1fbaA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE


(Oryctolagus
cuniculus)
PF00274
(Glycolytic)
4 THR A1205
LEU A1209
VAL A1212
LEU A1216
None
0.48A 1fbmB-1fdjA:
0.0
1fbmB-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8d QA-2 ANTIGEN

(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 THR A 178
LEU A 179
VAL A  28
LEU A   5
None
1.02A 1fbmB-1k8dA:
undetectable
1fbmB-1k8dA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzr ERYTHRONOLIDE
SYNTHASE


(Saccharopolyspora
erythraea)
PF08990
(Docking)
4 THR A 108
LEU A 104
VAL A 101
LEU A  97
None
0.91A 1fbmB-1pzrA:
1.7
1fbmB-1pzrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus)
PF01728
(FtsJ)
4 THR A 161
LEU A 165
VAL A 168
LEU A 172
None
0.69A 1fbmB-1r6aA:
undetectable
1fbmB-1r6aA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens)
PF08623
(TIP120)
4 THR C 611
LEU C 612
VAL C 647
LEU C 648
None
0.91A 1fbmB-1u6gC:
0.0
1fbmB-1u6gC:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus)
PF01965
(DJ-1_PfpI)
4 THR A 173
LEU A 174
VAL A 144
LEU A 197
None
0.90A 1fbmB-1u9cA:
undetectable
1fbmB-1u9cA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus)
PF03065
(Glyco_hydro_57)
PF09210
(DUF1957)
4 THR A  35
LEU A  39
VAL A  42
LEU A  46
None
0.60A 1fbmB-1ufaA:
undetectable
1fbmB-1ufaA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME


(Campylobacter
jejuni)
PF01128
(IspD)
PF02542
(YgbB)
4 THR A  38
LEU A  41
VAL A 102
LEU A 106
None
0.72A 1fbmB-1w55A:
undetectable
1fbmB-1w55A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465


(Thermus
thermophilus)
PF03641
(Lysine_decarbox)
4 THR A 144
LEU A 148
VAL A 151
LEU A 155
PO4  A 501 (-3.9A)
None
None
None
0.84A 1fbmB-1wekA:
undetectable
1fbmB-1wekA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens)
PF00274
(Glycolytic)
4 THR A 206
LEU A 210
VAL A 213
LEU A 217
None
0.46A 1fbmB-1xfbA:
undetectable
1fbmB-1xfbA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E


(Mus musculus)
PF00755
(Carn_acyltransf)
4 THR A 241
LEU A 240
VAL A 380
LEU A 377
None
1.02A 1fbmB-1xl8A:
undetectable
1fbmB-1xl8A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG


(Bacillus
subtilis)
PF07883
(Cupin_2)
4 THR A  34
LEU A  50
VAL A 115
LEU A  72
None
1.08A 1fbmB-1y3tA:
undetectable
1fbmB-1y3tA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvt TOPOISOMERASE IV
SUBUNIT A


(Escherichia
coli)
PF03989
(DNA_gyraseA_C)
4 THR A 559
LEU A 560
VAL A 510
LEU A 504
None
0.89A 1fbmB-1zvtA:
undetectable
1fbmB-1zvtA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A


(Escherichia
coli)
PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C)
4 THR A 559
LEU A 560
VAL A 510
LEU A 504
None
1.05A 1fbmB-1zvuA:
undetectable
1fbmB-1zvuA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE


(Chromobacterium
violaceum)
PF01503
(PRA-PH)
4 THR A  48
LEU A  67
VAL A  41
LEU A  74
None
1.02A 1fbmB-2a7wA:
undetectable
1fbmB-2a7wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA


(Agrobacterium
fabrum)
PF02464
(CinA)
4 THR A 146
LEU A 150
VAL A 153
LEU A 157
None
0.64A 1fbmB-2a9sA:
undetectable
1fbmB-2a9sA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING


(Homo sapiens)
PF00017
(SH2)
4 THR A 106
LEU A 105
VAL A  90
LEU A  89
None
1.03A 1fbmB-2cs0A:
undetectable
1fbmB-2cs0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A


(Homo sapiens)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8)
4 THR A 310
LEU A 308
VAL A 303
LEU A 279
None
1.12A 1fbmB-2id5A:
undetectable
1fbmB-2id5A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqb PROBABLE
BETA-LACTAMASE


(Staphylococcus
aureus)
PF16229
(DUF4888)
4 THR A  95
LEU A  98
VAL A  14
LEU A  10
None
0.95A 1fbmB-2mqbA:
undetectable
1fbmB-2mqbA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN-6

(Homo sapiens)
no annotation 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
None
0.81A 1fbmB-2npsD:
3.9
1fbmB-2npsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN


(Shewanella
oneidensis)
PF08933
(DUF1864)
4 THR A 320
LEU A 194
VAL A 313
LEU A 187
None
0.98A 1fbmB-2nwbA:
undetectable
1fbmB-2nwbA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus)
PF11099
(M11L)
4 THR A  83
LEU A  87
VAL A  90
LEU A  94
None
0.90A 1fbmB-2o42A:
undetectable
1fbmB-2o42A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1


(Homo sapiens)
PF00282
(Pyridoxal_deC)
4 THR A 113
LEU A 117
VAL A 120
LEU A 124
None
0.66A 1fbmB-2okjA:
undetectable
1fbmB-2okjA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2


(Homo sapiens)
PF00282
(Pyridoxal_deC)
4 THR A 391
LEU A 407
VAL A 409
LEU A 414
None
0.98A 1fbmB-2okkA:
undetectable
1fbmB-2okkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1


(Homo sapiens)
PF00620
(RhoGAP)
4 THR A 379
LEU A 378
VAL A 483
LEU A 480
None
1.10A 1fbmB-2ovjA:
undetectable
1fbmB-2ovjA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1


(Bos taurus)
PF02238
(COX7a)
4 THR J  27
LEU J  31
VAL J  34
LEU J  38
None
0.64A 1fbmB-2y69J:
3.0
1fbmB-2y69J:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis)
PF13469
(Sulfotransfer_3)
4 THR A  54
LEU A  53
VAL A  10
LEU A  44
None
1.12A 1fbmB-2zq5A:
undetectable
1fbmB-2zq5A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE


(Arabidopsis
thaliana)
PF00348
(polyprenyl_synt)
4 THR A 209
LEU A 208
VAL A 154
LEU A 146
None
1.05A 1fbmB-3aq0A:
undetectable
1fbmB-3aq0A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A


(Oryctolagus
cuniculus)
PF00274
(Glycolytic)
4 THR A 205
LEU A 209
VAL A 212
LEU A 216
None
0.51A 1fbmB-3bv4A:
undetectable
1fbmB-3bv4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2


(Rattus
norvegicus)
PF01150
(GDA1_CD39)
4 THR A 136
LEU A 140
VAL A 143
LEU A 147
None
0.63A 1fbmB-3cj1A:
undetectable
1fbmB-3cj1A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3


(Saccharomyces
cerevisiae)
PF03571
(Peptidase_M49)
4 THR A  84
LEU A  88
VAL A  91
LEU A  95
None
0.50A 1fbmB-3cskA:
undetectable
1fbmB-3cskA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1a HEMOGLOBIN SUBUNIT
ALPHA-1/2


(Capra hircus)
PF00042
(Globin)
4 THR A  79
LEU A  76
VAL A 132
LEU A 129
None
1.05A 1fbmB-3d1aA:
undetectable
1fbmB-3d1aA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE


(Listeria
monocytogenes)
PF00682
(HMGL-like)
4 THR X 227
LEU X 240
VAL X 243
LEU X 247
None
0.95A 1fbmB-3ewbX:
undetectable
1fbmB-3ewbX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvw DIGUANYLATE-CYCLASE
(DGC)


(Pseudomonas
aeruginosa)
PF00990
(GGDEF)
4 THR A 238
LEU A 250
VAL A 196
LEU A 292
None
1.02A 1fbmB-3hvwA:
undetectable
1fbmB-3hvwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0c E2 ENVELOPE
GLYCOPROTEIN


(Venezuelan
equine
encephalitis
virus)
PF00943
(Alpha_E2_glycop)
4 THR B  65
LEU B  79
VAL B  82
LEU B  84
None
1.11A 1fbmB-3j0cB:
undetectable
1fbmB-3j0cB:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN


(Escherichia
coli)
PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
4 THR B  55
LEU B  59
VAL B 380
LEU B 410
None
1.08A 1fbmB-3k70B:
undetectable
1fbmB-3k70B:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Babesia bovis)
PF00274
(Glycolytic)
4 THR A 204
LEU A 208
VAL A 211
LEU A 215
None
0.49A 1fbmB-3kx6A:
undetectable
1fbmB-3kx6A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5


(West Nile virus)
PF01728
(FtsJ)
4 THR A 161
LEU A 165
VAL A 168
LEU A 172
None
0.61A 1fbmB-3lkzA:
undetectable
1fbmB-3lkzA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Bartonella
henselae)
PF00274
(Glycolytic)
4 THR A 199
LEU A 203
VAL A 206
LEU A 210
None
0.57A 1fbmB-3mmtA:
undetectable
1fbmB-3mmtA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Trypanosoma
brucei)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
4 THR A 435
LEU A 439
VAL A 442
LEU A 446
None
0.53A 1fbmB-3nvlA:
undetectable
1fbmB-3nvlA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwm PEPTIDE/BETA-2MICROG
LOBULIN/MHC CLASS I
H-2KD CHIMERIC
PROTEIN


(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 THR A 178
LEU A 179
VAL A  28
LEU A   5
None
1.06A 1fbmB-3nwmA:
undetectable
1fbmB-3nwmA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwv MHC CLASS I ANTIGEN

(Bos taurus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 THR A 177
LEU A 178
VAL A  27
LEU A   4
None
1.12A 1fbmB-3pwvA:
undetectable
1fbmB-3pwvA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq3 MHC CLASS I ANTIGEN

(Sus scrofa)
PF00129
(MHC_I)
PF07654
(C1-set)
4 THR A 178
LEU A 179
VAL A  28
LEU A   5
None
1.05A 1fbmB-3qq3A:
undetectable
1fbmB-3qq3A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE


(Xanthomonas
campestris)
PF00696
(AA_kinase)
PF04768
(NAT)
4 THR A 272
LEU A 213
VAL A  52
LEU A  53
None
1.09A 1fbmB-3s6kA:
undetectable
1fbmB-3s6kA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u60 DNA POLYMERASE
ACCESSORY PROTEIN 62


(Escherichia
virus T4)
PF16790
(Phage_clamp_A)
4 THR A 146
LEU A 151
VAL A 154
LEU A 158
None
0.89A 1fbmB-3u60A:
undetectable
1fbmB-3u60A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli)
PF10462
(Peptidase_M66)
4 THR A 308
LEU A 307
VAL A 348
LEU A 350
None
1.12A 1fbmB-3ujzA:
undetectable
1fbmB-3ujzA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukm POTASSIUM CHANNEL
SUBFAMILY K MEMBER 1


(Homo sapiens)
PF07885
(Ion_trans_2)
4 THR A 105
LEU A 108
VAL A  35
LEU A  32
None
1.06A 1fbmB-3ukmA:
undetectable
1fbmB-3ukmA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
4 THR A 149
LEU A 153
VAL A 156
LEU A 160
None
0.83A 1fbmB-3un1A:
undetectable
1fbmB-3un1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans)
PF00221
(Lyase_aromatic)
4 THR A 325
LEU A 329
VAL A 332
LEU A 336
None
1.03A 1fbmB-3unvA:
undetectable
1fbmB-3unvA:
5.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)


(Mus musculus)
PF11598
(COMP)
4 THR A  40
LEU A  44
VAL A  47
LEU A  51
STE  A   1 (-4.0A)
STE  A   1 ( 4.5A)
None
STE  A   1 (-4.4A)
0.53A 1fbmB-3v2pA:
5.5
1fbmB-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vj6 H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-37 ALPHA
CHAIN


(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 THR A 178
LEU A 179
VAL A  28
LEU A   5
None
1.05A 1fbmB-3vj6A:
undetectable
1fbmB-3vj6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE


(Eisenia fetida)
PF00759
(Glyco_hydro_9)
4 THR A 288
LEU A 291
VAL A 294
LEU A 298
GOL  A 506 (-4.7A)
GOL  A 506 ( 4.4A)
None
None
0.77A 1fbmB-3wc3A:
undetectable
1fbmB-3wc3A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC


(Bacillus
subtilis)
PF02463
(SMC_N)
4 THR A 184
LEU A 188
VAL A 191
LEU A 195
None
0.66A 1fbmB-3zgxA:
1.5
1fbmB-3zgxA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuc CELLULOSOMAL
SCAFFOLDIN


(Acetivibrio
cellulolyticus)
PF00942
(CBM_3)
4 THR A  97
LEU A  38
VAL A  41
LEU A  43
None
1.08A 1fbmB-3zucA:
undetectable
1fbmB-3zucA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N)
4 THR A 465
LEU A 462
VAL A 471
LEU A 475
None
1.00A 1fbmB-4b8bA:
undetectable
1fbmB-4b8bA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa)
PF00884
(Sulfatase)
4 THR A  54
LEU A  58
VAL A 410
LEU A 414
DDZ  A  51 ( 4.4A)
None
None
None
0.88A 1fbmB-4cxkA:
undetectable
1fbmB-4cxkA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Toxoplasma
gondii)
PF00274
(Glycolytic)
4 THR A 277
LEU A 281
VAL A 284
LEU A 288
None
0.51A 1fbmB-4d2jA:
undetectable
1fbmB-4d2jA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE


(Pantoea
ananatis)
PF01593
(Amino_oxidase)
4 THR A 324
LEU A 352
VAL A 372
LEU A 309
None
1.11A 1fbmB-4dgkA:
undetectable
1fbmB-4dgkA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens)
no annotation 4 THR A 139
LEU A 143
VAL A 146
LEU A 150
None
0.63A 1fbmB-4gxbA:
undetectable
1fbmB-4gxbA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 THR A  63
LEU A  62
VAL A  80
LEU A  83
None
None
NAG  A 901 ( 4.2A)
None
1.05A 1fbmB-4iigA:
undetectable
1fbmB-4iigA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda)
PF00069
(Pkinase)
4 THR A 277
LEU A 280
VAL A 269
LEU A 324
None
1.11A 1fbmB-4ix3A:
undetectable
1fbmB-4ix3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C


(Streptococcus
mutans)
no annotation 4 THR A 258
LEU A 262
VAL A 265
LEU A 269
None
0.38A 1fbmB-4l9aA:
undetectable
1fbmB-4l9aA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Acholeplasma
laidlawii)
PF13561
(adh_short_C2)
4 THR A 183
LEU A 186
VAL A 189
LEU A 193
NAD  A 301 (-2.7A)
None
None
None
0.94A 1fbmB-4nbtA:
undetectable
1fbmB-4nbtA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli)
PF00854
(PTR2)
4 THR A 463
LEU A 467
VAL A 470
LEU A 474
None
0.53A 1fbmB-4q65A:
undetectable
1fbmB-4q65A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN


(Streptomyces
scabiei)
PF00067
(p450)
4 THR A 235
LEU A 239
VAL A 242
LEU A 246
None
None
HEM  A 501 ( 4.1A)
HEM  A 501 ( 4.8A)
0.51A 1fbmB-4tpnA:
undetectable
1fbmB-4tpnA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1


(Homo sapiens)
PF01463
(LRRCT)
PF13855
(LRR_8)
4 THR A  30
LEU A  54
VAL A  57
LEU A  80
None
1.03A 1fbmB-4u7lA:
undetectable
1fbmB-4u7lA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE


(Prochloron sp.)
no annotation 4 THR A1127
LEU A1125
VAL A1085
LEU A1082
None
1.09A 1fbmB-4uvqA:
undetectable
1fbmB-4uvqA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbp CAPRIN-1

(Homo sapiens)
no annotation 4 THR A 148
LEU A 152
VAL A 155
LEU A 159
None
0.81A 1fbmB-4wbpA:
undetectable
1fbmB-4wbpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtx INTEGRIN BETA-4

(Homo sapiens)
PF00041
(fn3)
4 THR A1632
LEU A1631
VAL A1606
LEU A1605
None
1.10A 1fbmB-4wtxA:
undetectable
1fbmB-4wtxA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE


(Plasmodium
falciparum)
PF01467
(CTP_transf_like)
4 THR A 676
LEU A 677
VAL A 683
LEU A 649
None
1.01A 1fbmB-4zcsA:
undetectable
1fbmB-4zcsA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II)
4 THR K 992
LEU K 996
VAL K 999
LEU K1003
None
1.08A 1fbmB-5anbK:
undetectable
1fbmB-5anbK:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Vibrio
vulnificus)
PF03466
(LysR_substrate)
4 THR A 289
LEU A 293
VAL A 296
LEU A 300
None
0.60A 1fbmB-5b7dA:
undetectable
1fbmB-5b7dA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Pseudomonas
aeruginosa)
PF00275
(EPSP_synthase)
4 THR A 248
LEU A 384
VAL A 380
LEU A   4
None
1.01A 1fbmB-5bq2A:
undetectable
1fbmB-5bq2A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN


(Chaetomium
thermophilum)
PF09439
(SRPRB)
4 THR B 216
LEU B 220
VAL B 223
LEU B 227
None
0.72A 1fbmB-5ck3B:
undetectable
1fbmB-5ck3B:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
4 THR A1229
LEU A1183
VAL A1186
LEU A1190
None
0.92A 1fbmB-5cslA:
undetectable
1fbmB-5cslA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus)
no annotation 4 THR B1050
LEU B1081
VAL B1057
LEU B1061
None
1.07A 1fbmB-5dlqB:
undetectable
1fbmB-5dlqB:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN


(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
4 THR A 178
LEU A 179
VAL A  28
LEU A   5
None
1.04A 1fbmB-5gsbA:
undetectable
1fbmB-5gsbA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3w FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN


(Streptococcus
suis)
PF05670
(DUF814)
PF05833
(FbpA)
4 THR A 117
LEU A 121
VAL A 124
LEU A 128
None
0.56A 1fbmB-5h3wA:
2.5
1fbmB-5h3wA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF08326
(ACC_central)
4 THR A1229
LEU A1183
VAL A1186
LEU A1190
None
0.92A 1fbmB-5i6eA:
undetectable
1fbmB-5i6eA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
4 THR A 676
LEU A 675
VAL A 666
LEU A 662
None
1.08A 1fbmB-5j6sA:
undetectable
1fbmB-5j6sA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
4 THR A 161
LEU A 165
VAL A 168
LEU A 172
None
0.81A 1fbmB-5jjrA:
undetectable
1fbmB-5jjrA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE


(Klebsiella
pneumoniae)
PF03739
(YjgP_YjgQ)
4 THR F  75
LEU F  72
VAL F 284
LEU F 281
None
0.93A 1fbmB-5l75F:
undetectable
1fbmB-5l75F:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1


(Saccharomyces
cerevisiae)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
4 THR C 114
LEU C 113
VAL C  78
LEU C 106
THR  C 114 ( 0.8A)
LEU  C 113 ( 0.6A)
VAL  C  78 ( 0.6A)
LEU  C 106 ( 0.5A)
0.97A 1fbmB-5lmxC:
undetectable
1fbmB-5lmxC:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens)
no annotation 4 THR A 180
LEU A 243
VAL A 388
LEU A 372
None
1.11A 1fbmB-5m3xA:
undetectable
1fbmB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
4 THR A 528
LEU A 532
VAL A 535
LEU A 539
None
0.52A 1fbmB-5m5pA:
undetectable
1fbmB-5m5pA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli)
PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30)
4 THR A 166
LEU A 139
VAL A 162
LEU A  82
None
0.76A 1fbmB-5n8oA:
undetectable
1fbmB-5n8oA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7


(Homo sapiens)
no annotation 4 THR A  79
LEU A 109
VAL A 112
LEU A 116
None
0.85A 1fbmB-5nfnA:
undetectable
1fbmB-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nod SERINE/THREONINE-PRO
TEIN KINASE STKP


(Streptococcus
pneumoniae)
no annotation 4 THR A 595
LEU A 599
VAL A 603
LEU A 640
None
0.90A 1fbmB-5nodA:
undetectable
1fbmB-5nodA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus)
no annotation 4 THR A 172
LEU A 184
VAL A 292
LEU A  23
None
1.05A 1fbmB-5o6vA:
undetectable
1fbmB-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 4 THR A 267
LEU A 266
VAL A 276
LEU A 278
None
1.09A 1fbmB-5obuA:
undetectable
1fbmB-5obuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Neisseria
meningitidis)
no annotation 4 THR A 133
LEU A 137
VAL A 140
LEU A 144
None
0.99A 1fbmB-5ugjA:
undetectable
1fbmB-5ugjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umg DIHYDROPTEROATE
SYNTHASE


(Klebsiella
pneumoniae)
PF00809
(Pterin_bind)
4 THR A 262
LEU A 266
VAL A 269
LEU A 273
None
0.57A 1fbmB-5umgA:
undetectable
1fbmB-5umgA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhf 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3


(Homo sapiens)
PF01399
(PCI)
PF08375
(Rpn3_C)
4 THR V 327
LEU V 331
VAL V 334
LEU V 338
None
0.94A 1fbmB-5vhfV:
2.8
1fbmB-5vhfV:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3


(Homo sapiens)
PF01399
(PCI)
PF08375
(Rpn3_C)
4 THR V 327
LEU V 331
VAL V 334
LEU V 338
None
0.97A 1fbmB-5vhsV:
undetectable
1fbmB-5vhsV:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1


(Homo sapiens)
PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3)
4 THR A  22
LEU A  26
VAL A  29
LEU A  33
None
0.91A 1fbmB-5xjyA:
undetectable
1fbmB-5xjyA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN


(Felis catus)
no annotation 4 THR A 179
LEU A 180
VAL A  29
LEU A   6
None
1.07A 1fbmB-5xmmA:
undetectable
1fbmB-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-)
no annotation 4 THR A 125
LEU A 126
VAL A  68
LEU A  69
None
None
None
GOL  A 302 ( 4.7A)
1.02A 1fbmB-5zqeA:
undetectable
1fbmB-5zqeA:
undetectable