SIMILAR PATTERNS OF AMINO ACIDS FOR 1FBM_B_RTLB951

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		4 THR A  79
LEU A  82
LEU A  89
GLN A  92
 None
 0.88A 1fbmA-1b5lA:
0.0		 1fbmA-1b5lA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bog ANTIBODY (CB 4-1)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR B  87
LEU B  86
LEU B  20
GLN B   6
 None
 1.22A 1fbmA-1bogB:
undetectable		 1fbmA-1bogB:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 THR A  95
LEU A 220
LEU A  60
GLN A  56
 None
 0.89A 1fbmA-1cbyA:
0.0		 1fbmA-1cbyA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 THR A 393
LEU A 395
LEU A 422
GLN A 427
 None
 1.23A 1fbmA-1gytA:
0.0		 1fbmA-1gytA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i3g ANTIBODY FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 THR H  97
LEU H  96
LEU H  21
GLN H   6
 None
 1.22A 1fbmA-1i3gH:
undetectable		 1fbmA-1i3gH:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8k EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
LIGHT CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR
ANTIBODY MR1SCFV
HEAVY CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 THR A  25
LEU A   4
LEU B 345
GLN B 339
 None
 1.25A 1fbmA-1i8kA:
undetectable		 1fbmA-1i8kA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		4 THR A 278
LEU A 279
LEU A 312
GLN A 320
 None
 1.23A 1fbmA-1iy2A:
0.0		 1fbmA-1iy2A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnn MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  87
LEU H  86
LEU H  20
GLN H   6
 None
 1.27A 1fbmA-1jnnH:
undetectable		 1fbmA-1jnnH:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		4 THR A 227
LEU A 223
LEU A 216
GLN A 213
 None
 1.15A 1fbmA-1js4A:
undetectable		 1fbmA-1js4A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 0.66A 1fbmA-1lpeA:
undetectable		 1fbmA-1lpeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 THR A 347
LEU A 350
LEU A 358
GLN A 141
 None
 1.22A 1fbmA-1lq2A:
undetectable		 1fbmA-1lq2A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqb SINGLE-CHAIN
ANTIBODY FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		4 THR A  87
LEU A  86
LEU A  20
GLN A   6
 None
 1.23A 1fbmA-1nqbA:
undetectable		 1fbmA-1nqbA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		4 THR A 278
LEU A 280
LEU A 190
GLN A 187
 None
 1.23A 1fbmA-1nrkA:
undetectable		 1fbmA-1nrkA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 THR A 176
LEU A 143
LEU A 103
GLN A 127
 None
 0.96A 1fbmA-1r6aA:
undetectable		 1fbmA-1r6aA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica) 		PF00270
(DEAD) 		4 THR A 235
LEU A 239
LEU A 246
GLN A 249
 SO4  A1001 (-3.8A)
None
None
None
 1.15A 1fbmA-1wrbA:
undetectable		 1fbmA-1wrbA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		4 THR A 299
LEU A 312
LEU A 271
GLN A 267
 None
 1.18A 1fbmA-1wruA:
undetectable		 1fbmA-1wruA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkh SPLICING FACTOR 3
SUBUNIT 1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 THR A  31
LEU A  67
LEU A  54
GLN A  52
 None
 1.12A 1fbmA-1zkhA:
undetectable		 1fbmA-1zkhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 THR A  75
LEU A  78
LEU A  39
GLN A  47
 None
 1.13A 1fbmA-2c2yA:
undetectable		 1fbmA-2c2yA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 THR X 300
LEU X 299
LEU X 256
GLN X 184
 None
 0.96A 1fbmA-2f6hX:
undetectable		 1fbmA-2f6hX:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 THR A 163
LEU A 167
LEU A 174
GLN A 177
 None
 1.21A 1fbmA-2fmtA:
undetectable		 1fbmA-2fmtA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iel HYPOTHETICAL PROTEIN
TT0030

(Thermus
thermophilus) 		no annotation 4 THR A  11
LEU A  17
LEU A  24
GLN A  27
 None
 1.22A 1fbmA-2ielA:
undetectable		 1fbmA-2ielA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 173
LEU A 180
LEU A 257
GLN A 215
 None
 1.26A 1fbmA-2jiiA:
undetectable		 1fbmA-2jiiA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kc3 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 1.18A 1fbmA-2kc3A:
undetectable		 1fbmA-2kc3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 1.24A 1fbmA-2l7bA:
undetectable		 1fbmA-2l7bA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0m MINOR AMPULLATE
FIBROIN 1

(Nephila
antipodiana) 		PF11260
(Spidroin_MaSp) 		4 THR A  52
LEU A  55
LEU A  62
GLN A  65
 None
 1.04A 1fbmA-2m0mA:
undetectable		 1fbmA-2m0mA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS) 		4 THR A 158
LEU A 162
LEU A 169
GLN A 172
 None
 0.89A 1fbmA-2o3bA:
undetectable		 1fbmA-2o3bA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  83
LEU H  82
LEU H  20
GLN H   6
 None
 1.17A 1fbmA-2op4H:
undetectable		 1fbmA-2op4H:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
9) 		PF00500
(Late_protein_L1) 		4 THR A 154
LEU A 156
LEU A 246
GLN A 315
 None
 1.06A 1fbmA-2r5jA:
undetectable		 1fbmA-2r5jA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 THR A  95
LEU A 220
LEU A  60
GLN A  56
 THR  A  95 ( 0.8A)
LEU  A 220 ( 0.6A)
LEU  A  60 ( 0.5A)
GLN  A  56 ( 0.6A)
 0.74A 1fbmA-2rciA:
undetectable		 1fbmA-2rciA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3z PUTATIVE DEACETYLASE

(Streptococcus
mutans) 		PF01522
(Polysacc_deac_1) 		4 THR A 220
LEU A 222
LEU A 229
GLN A 232
 None
 1.13A 1fbmA-2w3zA:
undetectable		 1fbmA-2w3zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 352
LEU A 343
LEU A 367
GLN A 358
 None
 1.13A 1fbmA-2wanA:
undetectable		 1fbmA-2wanA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 THR A 611
LEU A 648
LEU A 780
GLN A 306
 None
 1.23A 1fbmA-2wyhA:
undetectable		 1fbmA-2wyhA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 THR A 151
LEU A 150
LEU A 162
GLN A 165
 None
 1.14A 1fbmA-2yheA:
undetectable		 1fbmA-2yheA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 THR A 287
LEU A 288
LEU A 309
GLN A 297
 None
 1.16A 1fbmA-3a3jA:
undetectable		 1fbmA-3a3jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 THR B 237
LEU B 240
LEU B 247
GLN B 250
 None
 0.74A 1fbmA-3aqcB:
undetectable		 1fbmA-3aqcB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crc PROTEIN MAZG

(Escherichia
coli) 		PF03819
(MazG) 		4 THR A 201
LEU A 197
LEU A 190
GLN A 187
 None
 0.88A 1fbmA-3crcA:
undetectable		 1fbmA-3crcA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		4 THR A 408
LEU A 322
LEU A 286
GLN A 287
 None
 1.21A 1fbmA-3e2vA:
undetectable		 1fbmA-3e2vA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 THR A 120
LEU A 119
LEU A 112
GLN A 109
 None
 1.14A 1fbmA-3e6eA:
undetectable		 1fbmA-3e6eA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 THR A 628
LEU A 627
LEU A 712
GLN A 715
 None
 1.10A 1fbmA-3eh2A:
undetectable		 1fbmA-3eh2A:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 THR A 577
LEU A 576
LEU A 564
GLN A 562
 NAG  A 761 (-3.8A)
None
None
None
 1.20A 1fbmA-3fxiA:
undetectable		 1fbmA-3fxiA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 THR A 109
LEU A 113
LEU A 120
GLN A 123
 None
 0.85A 1fbmA-3g87A:
undetectable		 1fbmA-3g87A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 THR A  25
LEU A  28
LEU A 220
GLN A 259
 None
 1.13A 1fbmA-3gdcA:
undetectable		 1fbmA-3gdcA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxt 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE

(Homo sapiens) 		PF01812
(5-FTHF_cyc-lig) 		4 THR A 170
LEU A 171
LEU A  36
GLN A  32
 None
 1.19A 1fbmA-3hxtA:
undetectable		 1fbmA-3hxtA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A  24
LEU A  27
LEU A  34
GLN A  37
 None
 1.25A 1fbmA-3i3wA:
undetectable		 1fbmA-3i3wA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8w H263.A2 HEAVY CHAIN

(Mus musculus) 		no annotation 4 THR H  83
LEU H  82
LEU H  20
GLN H   6
 None
 1.24A 1fbmA-3j8wH:
undetectable		 1fbmA-3j8wH:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l40 BRCT-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF16770
(RTT107_BRCT_5) 		4 THR A 708
LEU A 712
LEU A 771
GLN A 767
 None
 1.13A 1fbmA-3l40A:
undetectable		 1fbmA-3l40A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln6 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Streptococcus
agalactiae) 		PF01071
(GARS_A)
PF04262
(Glu_cys_ligase) 		4 THR A 384
LEU A 191
LEU A 371
GLN A 368
 None
 1.23A 1fbmA-3ln6A:
undetectable		 1fbmA-3ln6A:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lso PUTATIVE MEMBRANE
ANCHORED PROTEIN

(Corynebacterium
diphtheriae) 		PF16640
(Big_3_5) 		4 THR B 168
LEU B 167
LEU B 124
GLN B 128
 None
 1.15A 1fbmA-3lsoB:
undetectable		 1fbmA-3lsoB:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 430
LEU A 428
LEU A 330
GLN A 331
 None
 1.24A 1fbmA-3m49A:
undetectable		 1fbmA-3m49A:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 THR A 490
LEU A 512
LEU A 468
GLN A 472
 None
 1.26A 1fbmA-3npeA:
undetectable		 1fbmA-3npeA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		4 THR B 666
LEU B 669
LEU B 676
GLN B 679
 None
 1.25A 1fbmA-3ojaB:
3.5		 1fbmA-3ojaB:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 THR A 493
LEU A 497
LEU A 504
GLN A 507
 None
 0.62A 1fbmA-3ojaA:
4.2		 1fbmA-3ojaA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 THR A 171
LEU A 172
LEU A 210
GLN A 207
 NAD  A 400 (-4.9A)
None
None
None
 1.22A 1fbmA-3qbdA:
undetectable		 1fbmA-3qbdA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8b G5-8

(Rattus
norvegicus) 		PF07686
(V-set) 		4 THR B  98
LEU B  99
LEU B  43
GLN B  37
 None
 1.21A 1fbmA-3r8bB:
undetectable		 1fbmA-3r8bB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		no annotation 4 THR J 565
LEU J 561
LEU J 554
GLN J 551
 None
 1.07A 1fbmA-3s88J:
undetectable		 1fbmA-3s88J:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzv ANTI-DENGUE MAB 4E11

(Mus musculus) 		PF07686
(V-set) 		4 THR B  88
LEU B  87
LEU B  21
GLN B   7
 None
 1.16A 1fbmA-3uzvB:
undetectable		 1fbmA-3uzvB:
11.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)

(Mus musculus) 		PF11598
(COMP) 		4 THR A  40
LEU A  44
LEU A  51
GLN A  54
 STE  A   1 (-4.0A)
STE  A   1 ( 4.5A)
STE  A   1 (-4.4A)
STE  A   1 (-3.4A)
 0.45A 1fbmA-3v2pA:
5.6		 1fbmA-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vhj BFPC

(Escherichia
coli) 		no annotation 4 THR A  40
LEU A  39
LEU A 161
GLN A  71
 None
 1.11A 1fbmA-3vhjA:
undetectable		 1fbmA-3vhjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx4 PUTATIVE ABC
TRANSPORTER,
ATP-BINDING PROTEIN
COMA

(Streptococcus
mutans) 		PF00005
(ABC_tran) 		4 THR A 543
LEU A 544
LEU A 549
GLN A 742
 ATP  A 801 (-3.8A)
None
None
None
 1.16A 1fbmA-3vx4A:
undetectable		 1fbmA-3vx4A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE

(Enterococcus
mundtii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A 129
LEU A 128
LEU A  94
GLN A  85
 None
 1.14A 1fbmA-3wsvA:
undetectable		 1fbmA-3wsvA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 THR A 176
LEU A 173
LEU A 184
GLN A 518
 None
 1.21A 1fbmA-4a2qA:
undetectable		 1fbmA-4a2qA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 THR A  35
LEU A 172
LEU A 165
GLN A 162
 None
 1.23A 1fbmA-4arsA:
undetectable		 1fbmA-4arsA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 THR A1623
LEU A1627
LEU A 335
GLN A 332
 None
 1.14A 1fbmA-4c3hA:
2.5		 1fbmA-4c3hA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		4 THR A 176
LEU A 180
LEU A 159
GLN A 156
 None
 1.15A 1fbmA-4eogA:
undetectable		 1fbmA-4eogA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etn LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YWLE

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 THR A 130
LEU A 134
LEU A 141
GLN A 144
 None
 0.93A 1fbmA-4etnA:
undetectable		 1fbmA-4etnA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffz DENV1-E111 FAB
FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H  83
LEU H  82
LEU H  20
GLN H   6
 None
 1.23A 1fbmA-4ffzH:
undetectable		 1fbmA-4ffzH:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 THR B 938
LEU B 942
LEU B 978
GLN B 981
 None
 0.89A 1fbmA-4fhnB:
undetectable		 1fbmA-4fhnB:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkf CRISPR SYSTEM CMR
SUBUNIT CMR5

(Pyrococcus
furiosus) 		PF09701
(Cas_Cmr5) 		4 THR A  74
LEU A  69
LEU A 128
GLN A 131
 None
 1.00A 1fbmA-4gkfA:
undetectable		 1fbmA-4gkfA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1p NHEA

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 THR A  20
LEU A  21
LEU A  28
GLN A  31
 None
 1.14A 1fbmA-4k1pA:
undetectable		 1fbmA-4k1pA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 THR A 437
LEU A 416
LEU A 368
GLN A 365
 None
 1.00A 1fbmA-4lxrA:
undetectable		 1fbmA-4lxrA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 THR A 600
LEU A 599
LEU A 242
GLN A 440
 None
 1.26A 1fbmA-4mifA:
undetectable		 1fbmA-4mifA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		4 THR A  87
LEU A  91
LEU A  98
GLN A 101
 None
 0.59A 1fbmA-4ng3A:
undetectable		 1fbmA-4ng3A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A 236
LEU A 239
LEU A 208
GLN A 290
 None
 1.25A 1fbmA-4nndA:
undetectable		 1fbmA-4nndA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 4 THR A 242
LEU A 311
LEU A 148
GLN A 142
 None
ANP  A 401 (-4.7A)
None
None
 1.14A 1fbmA-4nzmA:
undetectable		 1fbmA-4nzmA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfs SUBSTRATE BINDING
PRITEIN S

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		4 THR S 130
LEU S 134
LEU S 141
GLN S 144
 None
 1.05A 1fbmA-4rfsS:
undetectable		 1fbmA-4rfsS:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 THR A3395
LEU A3399
LEU A3406
GLN A3409
 None
 1.22A 1fbmA-4rh7A:
undetectable		 1fbmA-4rh7A:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		4 THR A 342
LEU A 341
LEU A 353
GLN A 357
 None
 1.10A 1fbmA-4rkcA:
undetectable		 1fbmA-4rkcA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 THR A 291
LEU A 294
LEU A 319
GLN A 371
 None
 1.27A 1fbmA-4wz9A:
undetectable		 1fbmA-4wz9A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 THR A 222
LEU A 226
LEU A 233
GLN A 237
 None
 1.20A 1fbmA-4wziA:
undetectable		 1fbmA-4wziA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		4 THR A 156
LEU A 157
LEU A  52
GLN A  48
 None
 1.17A 1fbmA-4y1kA:
undetectable		 1fbmA-4y1kA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUCLEOPORIN NUP58

(Xenopus laevis) 		PF15967
(Nucleoporin_FG2) 		4 THR B 349
LEU B 353
LEU B 360
GLN B 363
 None
 0.85A 1fbmA-5c3lB:
undetectable		 1fbmA-5c3lB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 THR A 156
LEU A 160
LEU A 167
GLN A 170
 None
 1.03A 1fbmA-5c65A:
undetectable		 1fbmA-5c65A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR

(Ovis aries) 		PF01109
(GM_CSF) 		4 THR B  71
LEU B  66
LEU B  59
GLN B  56
 None
 1.26A 1fbmA-5d28B:
undetectable		 1fbmA-5d28B:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus) 		no annotation 4 THR A 413
LEU A 417
LEU A 424
GLN A 427
 None
 1.07A 1fbmA-5dn7A:
undetectable		 1fbmA-5dn7A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dol INITIATION-CONTROL
PROTEIN YABA

(Bacillus
subtilis) 		PF06156
(YabB) 		4 THR A   9
LEU A  13
LEU A  20
GLN A  23
 None
 0.74A 1fbmA-5dolA:
undetectable		 1fbmA-5dolA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 THR A 557
LEU A 561
LEU A 568
GLN A 571
 None
 1.16A 1fbmA-5e84A:
undetectable		 1fbmA-5e84A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 THR A 209
LEU A 210
LEU A 325
GLN A 322
 None
 1.06A 1fbmA-5fq6A:
undetectable		 1fbmA-5fq6A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htl MSHA BIOGENESIS
PROTEIN MSHE

(Vibrio cholerae) 		PF05157
(T2SSE_N) 		4 THR A  42
LEU A  39
LEU A  13
GLN A  60
 None
C2E  A 201 (-4.3A)
None
None
 1.26A 1fbmA-5htlA:
undetectable		 1fbmA-5htlA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huo NICOTINATE-NUCLEOTID
E DIPHOSPHORYLASE
(CARBOXYLATING)

(Streptococcus
pyogenes) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 THR A  85
LEU A  84
LEU A  57
GLN A  61
 None
 1.21A 1fbmA-5huoA:
undetectable		 1fbmA-5huoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 THR A 434
LEU A 433
LEU A 310
GLN A 312
 None
 1.13A 1fbmA-5huuA:
undetectable		 1fbmA-5huuA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7m DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		4 THR A 363
LEU A 311
LEU A 291
GLN A 290
 None
 1.17A 1fbmA-5i7mA:
undetectable		 1fbmA-5i7mA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqs PROTEIN TOPLESS

(Arabidopsis
thaliana) 		no annotation 4 THR A 165
LEU A 166
LEU A 174
GLN A 177
 None
 1.07A 1fbmA-5nqsA:
undetectable		 1fbmA-5nqsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t33 RHPA GP120 CORE

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		4 THR G 455
LEU G 454
LEU G 342
GLN G 339
 None
 1.09A 1fbmA-5t33G:
undetectable		 1fbmA-5t33G:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 THR A 453
LEU A 450
LEU A 469
GLN A 375
 None
 1.18A 1fbmA-5vocA:
undetectable		 1fbmA-5vocA:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 4 THR C 635
LEU C 647
LEU C 691
GLN C 694
 None
 1.18A 1fbmA-5x6oC:
undetectable		 1fbmA-5x6oC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xun ACETYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF13673
(Acetyltransf_10) 		4 THR A  64
LEU A  94
LEU A 161
GLN A 152
 None
 1.12A 1fbmA-5xunA:
undetectable		 1fbmA-5xunA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywz SUN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 THR A 828
LEU A 829
LEU A 777
GLN A 677
 None
 1.25A 1fbmA-5ywzA:
undetectable		 1fbmA-5ywzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 THR A 677
LEU A 665
LEU A 592
GLN A 553
 None
 0.94A 1fbmA-6en4A:
undetectable		 1fbmA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 THR A 321
LEU A 322
LEU A 269
GLN A 207
 None
 1.03A 1fbmA-6f9nA:
undetectable		 1fbmA-6f9nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Mus musculus) 		no annotation 4 THR N 201
LEU N 194
LEU N 148
GLN N  88
 None
 1.07A 1fbmA-6g72N:
undetectable		 1fbmA-6g72N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 THR A 212
LEU A 216
VAL A 219
LEU A 223
 None
 0.63A 1fbmB-1a5cA:
undetectable		 1fbmB-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.07A 1fbmB-1biiA:
undetectable		 1fbmB-1biiA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.44A 1fbmB-1fbaA:
undetectable		 1fbmB-1fbaA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.48A 1fbmB-1fdjA:
0.0		 1fbmB-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8d QA-2 ANTIGEN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.02A 1fbmB-1k8dA:
undetectable		 1fbmB-1k8dA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzr ERYTHRONOLIDE
SYNTHASE

(Saccharopolyspora
erythraea) 		PF08990
(Docking) 		4 THR A 108
LEU A 104
VAL A 101
LEU A  97
 None
 0.91A 1fbmB-1pzrA:
1.7		 1fbmB-1pzrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.69A 1fbmB-1r6aA:
undetectable		 1fbmB-1r6aA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.91A 1fbmB-1u6gC:
0.0		 1fbmB-1u6gC:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9c APC35852

(Geobacillus
stearothermophilus) 		PF01965
(DJ-1_PfpI) 		4 THR A 173
LEU A 174
VAL A 144
LEU A 197
 None
 0.90A 1fbmB-1u9cA:
undetectable		 1fbmB-1u9cA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 THR A  35
LEU A  39
VAL A  42
LEU A  46
 None
 0.60A 1fbmB-1ufaA:
undetectable		 1fbmB-1ufaA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.72A 1fbmB-1w55A:
undetectable		 1fbmB-1w55A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.84A 1fbmB-1wekA:
undetectable		 1fbmB-1wekA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		4 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.46A 1fbmB-1xfbA:
undetectable		 1fbmB-1xfbA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 THR A 241
LEU A 240
VAL A 380
LEU A 377
 None
 1.02A 1fbmB-1xl8A:
undetectable		 1fbmB-1xl8A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 THR A  34
LEU A  50
VAL A 115
LEU A  72
 None
 1.08A 1fbmB-1y3tA:
undetectable		 1fbmB-1y3tA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvt TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF03989
(DNA_gyraseA_C) 		4 THR A 559
LEU A 560
VAL A 510
LEU A 504
 None
 0.89A 1fbmB-1zvtA:
undetectable		 1fbmB-1zvtA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		4 THR A 559
LEU A 560
VAL A 510
LEU A 504
 None
 1.05A 1fbmB-1zvuA:
undetectable		 1fbmB-1zvuA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7w PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Chromobacterium
violaceum) 		PF01503
(PRA-PH) 		4 THR A  48
LEU A  67
VAL A  41
LEU A  74
 None
 1.02A 1fbmB-2a7wA:
undetectable		 1fbmB-2a7wA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.64A 1fbmB-2a9sA:
undetectable		 1fbmB-2a9sA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING

(Homo sapiens) 		PF00017
(SH2) 		4 THR A 106
LEU A 105
VAL A  90
LEU A  89
 None
 1.03A 1fbmB-2cs0A:
undetectable		 1fbmB-2cs0A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 THR A 310
LEU A 308
VAL A 303
LEU A 279
 None
 1.12A 1fbmB-2id5A:
undetectable		 1fbmB-2id5A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqb PROBABLE
BETA-LACTAMASE

(Staphylococcus
aureus) 		PF16229
(DUF4888) 		4 THR A  95
LEU A  98
VAL A  14
LEU A  10
 None
 0.95A 1fbmB-2mqbA:
undetectable		 1fbmB-2mqbA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN-6

(Homo sapiens) 		no annotation 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.81A 1fbmB-2npsD:
3.9		 1fbmB-2npsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		4 THR A 320
LEU A 194
VAL A 313
LEU A 187
 None
 0.98A 1fbmB-2nwbA:
undetectable		 1fbmB-2nwbA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		4 THR A  83
LEU A  87
VAL A  90
LEU A  94
 None
 0.90A 1fbmB-2o42A:
undetectable		 1fbmB-2o42A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 113
LEU A 117
VAL A 120
LEU A 124
 None
 0.66A 1fbmB-2okjA:
undetectable		 1fbmB-2okjA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 391
LEU A 407
VAL A 409
LEU A 414
 None
 0.98A 1fbmB-2okkA:
undetectable		 1fbmB-2okkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 THR A 379
LEU A 378
VAL A 483
LEU A 480
 None
 1.10A 1fbmB-2ovjA:
undetectable		 1fbmB-2ovjA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 THR J  27
LEU J  31
VAL J  34
LEU J  38
 None
 0.64A 1fbmB-2y69J:
3.0		 1fbmB-2y69J:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 THR A  54
LEU A  53
VAL A  10
LEU A  44
 None
 1.12A 1fbmB-2zq5A:
undetectable		 1fbmB-2zq5A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 THR A 209
LEU A 208
VAL A 154
LEU A 146
 None
 1.05A 1fbmB-3aq0A:
undetectable		 1fbmB-3aq0A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.51A 1fbmB-3bv4A:
undetectable		 1fbmB-3bv4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 THR A 136
LEU A 140
VAL A 143
LEU A 147
 None
 0.63A 1fbmB-3cj1A:
undetectable		 1fbmB-3cj1A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.50A 1fbmB-3cskA:
undetectable		 1fbmB-3cskA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1a HEMOGLOBIN SUBUNIT
ALPHA-1/2

(Capra hircus) 		PF00042
(Globin) 		4 THR A  79
LEU A  76
VAL A 132
LEU A 129
 None
 1.05A 1fbmB-3d1aA:
undetectable		 1fbmB-3d1aA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		4 THR X 227
LEU X 240
VAL X 243
LEU X 247
 None
 0.95A 1fbmB-3ewbX:
undetectable		 1fbmB-3ewbX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvw DIGUANYLATE-CYCLASE
(DGC)

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 THR A 238
LEU A 250
VAL A 196
LEU A 292
 None
 1.02A 1fbmB-3hvwA:
undetectable		 1fbmB-3hvwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0c E2 ENVELOPE
GLYCOPROTEIN

(Venezuelan
equine
encephalitis
virus) 		PF00943
(Alpha_E2_glycop) 		4 THR B  65
LEU B  79
VAL B  82
LEU B  84
 None
 1.11A 1fbmB-3j0cB:
undetectable		 1fbmB-3j0cB:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 THR B  55
LEU B  59
VAL B 380
LEU B 410
 None
 1.08A 1fbmB-3k70B:
undetectable		 1fbmB-3k70B:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.49A 1fbmB-3kx6A:
undetectable		 1fbmB-3kx6A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.61A 1fbmB-3lkzA:
undetectable		 1fbmB-3lkzA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 THR A 199
LEU A 203
VAL A 206
LEU A 210
 None
 0.57A 1fbmB-3mmtA:
undetectable		 1fbmB-3mmtA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.53A 1fbmB-3nvlA:
undetectable		 1fbmB-3nvlA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwm PEPTIDE/BETA-2MICROG
LOBULIN/MHC CLASS I
H-2KD CHIMERIC
PROTEIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.06A 1fbmB-3nwmA:
undetectable		 1fbmB-3nwmA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwv MHC CLASS I ANTIGEN

(Bos taurus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 177
LEU A 178
VAL A  27
LEU A   4
 None
 1.12A 1fbmB-3pwvA:
undetectable		 1fbmB-3pwvA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq3 MHC CLASS I ANTIGEN

(Sus scrofa) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.05A 1fbmB-3qq3A:
undetectable		 1fbmB-3qq3A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 THR A 272
LEU A 213
VAL A  52
LEU A  53
 None
 1.09A 1fbmB-3s6kA:
undetectable		 1fbmB-3s6kA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u60 DNA POLYMERASE
ACCESSORY PROTEIN 62

(Escherichia
virus T4) 		PF16790
(Phage_clamp_A) 		4 THR A 146
LEU A 151
VAL A 154
LEU A 158
 None
 0.89A 1fbmB-3u60A:
undetectable		 1fbmB-3u60A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 THR A 308
LEU A 307
VAL A 348
LEU A 350
 None
 1.12A 1fbmB-3ujzA:
undetectable		 1fbmB-3ujzA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukm POTASSIUM CHANNEL
SUBFAMILY K MEMBER 1

(Homo sapiens) 		PF07885
(Ion_trans_2) 		4 THR A 105
LEU A 108
VAL A  35
LEU A  32
 None
 1.06A 1fbmB-3ukmA:
undetectable		 1fbmB-3ukmA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 THR A 149
LEU A 153
VAL A 156
LEU A 160
 None
 0.83A 1fbmB-3un1A:
undetectable		 1fbmB-3un1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		4 THR A 325
LEU A 329
VAL A 332
LEU A 336
 None
 1.03A 1fbmB-3unvA:
undetectable		 1fbmB-3unvA:
5.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)

(Mus musculus) 		PF11598
(COMP) 		4 THR A  40
LEU A  44
VAL A  47
LEU A  51
 STE  A   1 (-4.0A)
STE  A   1 ( 4.5A)
None
STE  A   1 (-4.4A)
 0.53A 1fbmB-3v2pA:
5.5		 1fbmB-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vj6 H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, D-37 ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.05A 1fbmB-3vj6A:
undetectable		 1fbmB-3vj6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 THR A 288
LEU A 291
VAL A 294
LEU A 298
 GOL  A 506 (-4.7A)
GOL  A 506 ( 4.4A)
None
None
 0.77A 1fbmB-3wc3A:
undetectable		 1fbmB-3wc3A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 THR A 184
LEU A 188
VAL A 191
LEU A 195
 None
 0.66A 1fbmB-3zgxA:
1.5		 1fbmB-3zgxA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuc CELLULOSOMAL
SCAFFOLDIN

(Acetivibrio
cellulolyticus) 		PF00942
(CBM_3) 		4 THR A  97
LEU A  38
VAL A  41
LEU A  43
 None
 1.08A 1fbmB-3zucA:
undetectable		 1fbmB-3zucA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 THR A 465
LEU A 462
VAL A 471
LEU A 475
 None
 1.00A 1fbmB-4b8bA:
undetectable		 1fbmB-4b8bA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 THR A  54
LEU A  58
VAL A 410
LEU A 414
 DDZ  A  51 ( 4.4A)
None
None
None
 0.88A 1fbmB-4cxkA:
undetectable		 1fbmB-4cxkA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 THR A 277
LEU A 281
VAL A 284
LEU A 288
 None
 0.51A 1fbmB-4d2jA:
undetectable		 1fbmB-4d2jA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		4 THR A 324
LEU A 352
VAL A 372
LEU A 309
 None
 1.11A 1fbmB-4dgkA:
undetectable		 1fbmB-4dgkA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 THR A 139
LEU A 143
VAL A 146
LEU A 150
 None
 0.63A 1fbmB-4gxbA:
undetectable		 1fbmB-4gxbA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 THR A  63
LEU A  62
VAL A  80
LEU A  83
 None
None
NAG  A 901 ( 4.2A)
None
 1.05A 1fbmB-4iigA:
undetectable		 1fbmB-4iigA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		4 THR A 277
LEU A 280
VAL A 269
LEU A 324
 None
 1.11A 1fbmB-4ix3A:
undetectable		 1fbmB-4ix3A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 THR A 258
LEU A 262
VAL A 265
LEU A 269
 None
 0.38A 1fbmB-4l9aA:
undetectable		 1fbmB-4l9aA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Acholeplasma
laidlawii) 		PF13561
(adh_short_C2) 		4 THR A 183
LEU A 186
VAL A 189
LEU A 193
 NAD  A 301 (-2.7A)
None
None
None
 0.94A 1fbmB-4nbtA:
undetectable		 1fbmB-4nbtA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 THR A 463
LEU A 467
VAL A 470
LEU A 474
 None
 0.53A 1fbmB-4q65A:
undetectable		 1fbmB-4q65A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		4 THR A 235
LEU A 239
VAL A 242
LEU A 246
 None
None
HEM  A 501 ( 4.1A)
HEM  A 501 ( 4.8A)
 0.51A 1fbmB-4tpnA:
undetectable		 1fbmB-4tpnA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 THR A  30
LEU A  54
VAL A  57
LEU A  80
 None
 1.03A 1fbmB-4u7lA:
undetectable		 1fbmB-4u7lA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron sp.) 		no annotation 4 THR A1127
LEU A1125
VAL A1085
LEU A1082
 None
 1.09A 1fbmB-4uvqA:
undetectable		 1fbmB-4uvqA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbp CAPRIN-1

(Homo sapiens) 		no annotation 4 THR A 148
LEU A 152
VAL A 155
LEU A 159
 None
 0.81A 1fbmB-4wbpA:
undetectable		 1fbmB-4wbpA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wtx INTEGRIN BETA-4

(Homo sapiens) 		PF00041
(fn3) 		4 THR A1632
LEU A1631
VAL A1606
LEU A1605
 None
 1.10A 1fbmB-4wtxA:
undetectable		 1fbmB-4wtxA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		4 THR A 676
LEU A 677
VAL A 683
LEU A 649
 None
 1.01A 1fbmB-4zcsA:
undetectable		 1fbmB-4zcsA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		4 THR K 992
LEU K 996
VAL K 999
LEU K1003
 None
 1.08A 1fbmB-5anbK:
undetectable		 1fbmB-5anbK:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF03466
(LysR_substrate) 		4 THR A 289
LEU A 293
VAL A 296
LEU A 300
 None
 0.60A 1fbmB-5b7dA:
undetectable		 1fbmB-5b7dA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		4 THR A 248
LEU A 384
VAL A 380
LEU A   4
 None
 1.01A 1fbmB-5bq2A:
undetectable		 1fbmB-5bq2A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		4 THR B 216
LEU B 220
VAL B 223
LEU B 227
 None
 0.72A 1fbmB-5ck3B:
undetectable		 1fbmB-5ck3B:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.92A 1fbmB-5cslA:
undetectable		 1fbmB-5cslA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 THR B1050
LEU B1081
VAL B1057
LEU B1061
 None
 1.07A 1fbmB-5dlqB:
undetectable		 1fbmB-5dlqB:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 178
LEU A 179
VAL A  28
LEU A   5
 None
 1.04A 1fbmB-5gsbA:
undetectable		 1fbmB-5gsbA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3w FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05670
(DUF814)
PF05833
(FbpA) 		4 THR A 117
LEU A 121
VAL A 124
LEU A 128
 None
 0.56A 1fbmB-5h3wA:
2.5		 1fbmB-5h3wA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.92A 1fbmB-5i6eA:
undetectable		 1fbmB-5i6eA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 THR A 676
LEU A 675
VAL A 666
LEU A 662
 None
 1.08A 1fbmB-5j6sA:
undetectable		 1fbmB-5j6sA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.81A 1fbmB-5jjrA:
undetectable		 1fbmB-5jjrA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		4 THR F  75
LEU F  72
VAL F 284
LEU F 281
 None
 0.93A 1fbmB-5l75F:
undetectable		 1fbmB-5l75F:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 THR C 114
LEU C 113
VAL C  78
LEU C 106
 THR  C 114 ( 0.8A)
LEU  C 113 ( 0.6A)
VAL  C  78 ( 0.6A)
LEU  C 106 ( 0.5A)
 0.97A 1fbmB-5lmxC:
undetectable		 1fbmB-5lmxC:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 4 THR A 180
LEU A 243
VAL A 388
LEU A 372
 None
 1.11A 1fbmB-5m3xA:
undetectable		 1fbmB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 THR A 528
LEU A 532
VAL A 535
LEU A 539
 None
 0.52A 1fbmB-5m5pA:
undetectable		 1fbmB-5m5pA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		4 THR A 166
LEU A 139
VAL A 162
LEU A  82
 None
 0.76A 1fbmB-5n8oA:
undetectable		 1fbmB-5n8oA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 4 THR A  79
LEU A 109
VAL A 112
LEU A 116
 None
 0.85A 1fbmB-5nfnA:
undetectable		 1fbmB-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nod SERINE/THREONINE-PRO
TEIN KINASE STKP

(Streptococcus
pneumoniae) 		no annotation 4 THR A 595
LEU A 599
VAL A 603
LEU A 640
 None
 0.90A 1fbmB-5nodA:
undetectable		 1fbmB-5nodA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 4 THR A 172
LEU A 184
VAL A 292
LEU A  23
 None
 1.05A 1fbmB-5o6vA:
undetectable		 1fbmB-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 4 THR A 267
LEU A 266
VAL A 276
LEU A 278
 None
 1.09A 1fbmB-5obuA:
undetectable		 1fbmB-5obuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 THR A 133
LEU A 137
VAL A 140
LEU A 144
 None
 0.99A 1fbmB-5ugjA:
undetectable		 1fbmB-5ugjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umg DIHYDROPTEROATE
SYNTHASE

(Klebsiella
pneumoniae) 		PF00809
(Pterin_bind) 		4 THR A 262
LEU A 266
VAL A 269
LEU A 273
 None
 0.57A 1fbmB-5umgA:
undetectable		 1fbmB-5umgA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhf 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 THR V 327
LEU V 331
VAL V 334
LEU V 338
 None
 0.94A 1fbmB-5vhfV:
2.8		 1fbmB-5vhfV:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhs 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 3

(Homo sapiens) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		4 THR V 327
LEU V 331
VAL V 334
LEU V 338
 None
 0.97A 1fbmB-5vhsV:
undetectable		 1fbmB-5vhsV:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 THR A  22
LEU A  26
VAL A  29
LEU A  33
 None
 0.91A 1fbmB-5xjyA:
undetectable		 1fbmB-5xjyA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm MHC CLASS I ANTIGEN
ALPHA CHAIN

(Felis catus) 		no annotation 4 THR A 179
LEU A 180
VAL A  29
LEU A   6
 None
 1.07A 1fbmB-5xmmA:
undetectable		 1fbmB-5xmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 THR A 125
LEU A 126
VAL A  68
LEU A  69
 None
None
None
GOL  A 302 ( 4.7A)
 1.02A 1fbmB-5zqeA:
undetectable		 1fbmB-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 THR A 212
LEU A 216
VAL A 219
LEU A 223
 None
 0.73A 1fbmD-1a5cA:
0.0		 1fbmD-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 THR A 262
LEU A 263
VAL A 267
LEU A 271
 None
 0.98A 1fbmD-1a5cA:
0.0		 1fbmD-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		4 THR A 210
LEU A 213
VAL A  59
LEU A 151
 None
 0.91A 1fbmD-1at3A:
0.0		 1fbmD-1at3A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN BETA 1)

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 THR B  54
LEU B  57
VAL B  22
LEU B  25
 None
 0.86A 1fbmD-1awcB:
0.0		 1fbmD-1awcB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 THR A  54
LEU A  32
VAL A  33
LEU A  25
 None
 0.97A 1fbmD-1ayeA:
0.0		 1fbmD-1ayeA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		4 THR A  46
LEU A  48
VAL A  51
LEU A  55
 None
 0.86A 1fbmD-1b9bA:
undetectable		 1fbmD-1b9bA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bct BACTERIORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 THR A 170
LEU A 174
VAL A 177
LEU A 181
 None
 0.68A 1fbmD-1bctA:
1.8		 1fbmD-1bctA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 THR A 170
LEU A 174
VAL A 177
LEU A 181
 None
 0.70A 1fbmD-1brrA:
0.0		 1fbmD-1brrA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.62A 1fbmD-1fbaA:
0.0		 1fbmD-1fbaA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.55A 1fbmD-1fdjA:
0.0		 1fbmD-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3d ATP-PHOSPHORIBOSYLTR
ANSFERASE

(Escherichia
coli) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 THR A 235
LEU A 238
VAL A 241
LEU A 245
 None
 0.97A 1fbmD-1h3dA:
undetectable		 1fbmD-1h3dA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 THR A 152
LEU A 148
VAL A 145
LEU A 141
 None
 0.97A 1fbmD-1jqkA:
undetectable		 1fbmD-1jqkA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 THR A 577
LEU A 494
VAL A 584
LEU A 427
 None
 0.97A 1fbmD-1mpxA:
undetectable		 1fbmD-1mpxA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 THR A 783
LEU A 786
VAL A 750
LEU A 753
 None
 0.85A 1fbmD-1n11A:
undetectable		 1fbmD-1n11A:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6F
COMPLEX SUBUNIT PETG

(Chlamydomonas
reinhardtii) 		PF02529
(PetG) 		4 THR G  17
LEU G  13
VAL G  10
LEU G   6
 BCR  B 904 ( 4.4A)
BCR  B 904 ( 4.3A)
None
None
 0.98A 1fbmD-1q90G:
undetectable		 1fbmD-1q90G:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.69A 1fbmD-1r6aA:
undetectable		 1fbmD-1r6aA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj5 CONSERVED
HYPOTHETICAL PROTEIN
TM0160

(Thermotoga
maritima) 		PF02577
(DNase-RNase) 		4 THR A  57
LEU A  61
VAL A  64
LEU A  68
 None
 0.80A 1fbmD-1sj5A:
undetectable		 1fbmD-1sj5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 THR A  56
LEU A  39
VAL A  75
LEU A  23
 None
 0.94A 1fbmD-1smaA:
undetectable		 1fbmD-1smaA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		4 THR A 267
LEU A 266
VAL A 261
LEU A 259
 None
 0.92A 1fbmD-1sznA:
undetectable		 1fbmD-1sznA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.92A 1fbmD-1u6gC:
undetectable		 1fbmD-1u6gC:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 THR A  35
LEU A  39
VAL A  42
LEU A  46
 None
 0.54A 1fbmD-1ufaA:
undetectable		 1fbmD-1ufaA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 150
LEU A 154
VAL A 157
LEU A 161
 None
 0.79A 1fbmD-1vc2A:
undetectable		 1fbmD-1vc2A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.90A 1fbmD-1w55A:
undetectable		 1fbmD-1w55A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A2193
LEU A2197
VAL A2200
LEU A2204
 None
 0.75A 1fbmD-1wchA:
undetectable		 1fbmD-1wchA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.54A 1fbmD-1wekA:
undetectable		 1fbmD-1wekA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		4 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.63A 1fbmD-1xfbA:
undetectable		 1fbmD-1xfbA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		4 THR A 160
LEU A 164
VAL A 167
LEU A 171
 None
 0.68A 1fbmD-1y9uA:
undetectable		 1fbmD-1y9uA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		4 THR A  85
LEU A  89
VAL A  92
LEU A  96
 None
 0.52A 1fbmD-1yulA:
undetectable		 1fbmD-1yulA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.67A 1fbmD-2a9sA:
undetectable		 1fbmD-2a9sA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K

(Enterococcus
hirae) 		PF00137
(ATP-synt_C) 		4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.58A 1fbmD-2bl2A:
undetectable		 1fbmD-2bl2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 156
LEU A 160
VAL A 163
LEU A 167
 SO4  A1339 ( 4.3A)
None
None
None
 0.78A 1fbmD-2d2iA:
undetectable		 1fbmD-2d2iA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0j HYPOTHETICAL PROTEIN
SMU.848

(Streptococcus
mutans) 		PF04327
(Peptidase_Prp) 		4 THR A  19
LEU A  18
VAL A  36
LEU A  39
 None
 0.96A 1fbmD-2g0jA:
undetectable		 1fbmD-2g0jA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 THR A  19
LEU A  23
VAL A  26
LEU A  30
 None
 0.79A 1fbmD-2hg4A:
undetectable		 1fbmD-2hg4A:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl4 BH2032 PROTEIN

(Bacillus
halodurans) 		PF08818
(DUF1801) 		4 THR A  23
LEU A  27
VAL A  30
LEU A  37
 None
 0.95A 1fbmD-2kl4A:
undetectable		 1fbmD-2kl4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0m MINOR AMPULLATE
FIBROIN 1

(Nephila
antipodiana) 		PF11260
(Spidroin_MaSp) 		4 THR A  52
LEU A  55
VAL A  58
LEU A  62
 None
 0.88A 1fbmD-2m0mA:
undetectable		 1fbmD-2m0mA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN-6

(Homo sapiens) 		no annotation 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.65A 1fbmD-2npsD:
undetectable		 1fbmD-2npsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 THR A  36
LEU A  40
VAL A  42
LEU A  46
 None
 0.66A 1fbmD-2og2A:
undetectable		 1fbmD-2og2A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 113
LEU A 117
VAL A 120
LEU A 124
 None
 0.78A 1fbmD-2okjA:
undetectable		 1fbmD-2okjA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 107
LEU A 111
VAL A 114
LEU A 118
 None
 0.86A 1fbmD-2okkA:
undetectable		 1fbmD-2okkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.65A 1fbmD-2oy0A:
undetectable		 1fbmD-2oy0A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		4 THR A 120
LEU A 124
VAL A 127
LEU A 131
 ADP  A 300 (-3.6A)
None
None
None
 0.81A 1fbmD-2pl3A:
undetectable		 1fbmD-2pl3A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 THR A 394
LEU A 398
VAL A 401
LEU A 405
 None
 0.88A 1fbmD-2qfvA:
undetectable		 1fbmD-2qfvA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 121
LEU A 120
VAL A 155
LEU A 149
 None
 0.94A 1fbmD-2w5hA:
undetectable		 1fbmD-2w5hA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w83 C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 4

(Homo sapiens) 		PF16471
(JIP_LZII) 		4 THR C 409
LEU C 413
VAL C 416
LEU C 420
 None
 0.53A 1fbmD-2w83C:
undetectable		 1fbmD-2w83C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvw RBCX PROTEIN

(Anabaena sp. CA
= ATCC 33047) 		PF02341
(RcbX) 		4 THR I  19
LEU I  23
VAL I  26
LEU I  30
 None
 0.65A 1fbmD-2wvwI:
undetectable		 1fbmD-2wvwI:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 THR J  27
LEU J  31
VAL J  34
LEU J  38
 None
 0.37A 1fbmD-2y69J:
undetectable		 1fbmD-2y69J:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 THR A 202
LEU A 206
VAL A 209
LEU A 213
 None
 0.70A 1fbmD-2yr5A:
undetectable		 1fbmD-2yr5A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II
REACTION CENTER
PROTEIN I

(Thermosynechococcus
vulcanus) 		PF02532
(PsbI) 		4 THR I  13
LEU I  17
VAL I  20
LEU I  24
 None
 0.76A 1fbmD-3a0hI:
undetectable		 1fbmD-3a0hI:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 156
LEU A 160
VAL A 163
LEU A 167
 SO4  A1339 (-3.7A)
None
None
None
 0.75A 1fbmD-3b20A:
undetectable		 1fbmD-3b20A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 THR A 243
LEU A 247
VAL A 250
LEU A 254
 HEM  A 450 (-4.3A)
None
None
None
 0.63A 1fbmD-3bdzA:
undetectable		 1fbmD-3bdzA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu8 TELOMERIC
REPEAT-BINDING
FACTOR 2

(Homo sapiens) 		PF08558
(TRF) 		4 THR A  96
LEU A 100
VAL A 103
LEU A 107
 None
 0.78A 1fbmD-3bu8A:
undetectable		 1fbmD-3bu8A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.68A 1fbmD-3bv4A:
undetectable		 1fbmD-3bv4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 THR A 247
LEU A 251
VAL A 254
LEU A 258
 None
 0.64A 1fbmD-3c8tA:
undetectable		 1fbmD-3c8tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 THR A 136
LEU A 140
VAL A 143
LEU A 147
 None
 0.46A 1fbmD-3cj1A:
undetectable		 1fbmD-3cj1A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl3 ORF K13

(Human
gammaherpesvirus
8) 		PF01335
(DED) 		4 THR A   3
LEU A   7
VAL A  10
LEU A  14
 None
 0.73A 1fbmD-3cl3A:
undetectable		 1fbmD-3cl3A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.67A 1fbmD-3cskA:
undetectable		 1fbmD-3cskA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 154
LEU A 158
VAL A 161
LEU A 165
 None
 0.65A 1fbmD-3docA:
undetectable		 1fbmD-3docA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		4 THR X 227
LEU X 240
VAL X 243
LEU X 247
 None
 0.91A 1fbmD-3ewbX:
undetectable		 1fbmD-3ewbX:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6p TRANSCRIPTIONAL
REGULATORY PROTEIN
YYCF

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 THR A 106
LEU A 110
VAL A 113
LEU A 117
 None
 0.61A 1fbmD-3f6pA:
undetectable		 1fbmD-3f6pA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr3 NITROREDUCTASE

(Bartonella
henselae) 		PF00881
(Nitroreductase) 		4 THR A  56
LEU A  60
VAL A  63
LEU A  67
 None
 0.88A 1fbmD-3gr3A:
undetectable		 1fbmD-3gr3A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 THR A 211
LEU A 215
VAL A 218
LEU A 222
 GOL  A 283 ( 4.7A)
None
None
None
 0.49A 1fbmD-3h74A:
undetectable		 1fbmD-3h74A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.70A 1fbmD-3ibrA:
undetectable		 1fbmD-3ibrA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 4 THR Q 152
LEU Q 156
VAL Q 159
LEU Q 163
 None
 0.87A 1fbmD-3ksdQ:
undetectable		 1fbmD-3ksdQ:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.63A 1fbmD-3kx6A:
undetectable		 1fbmD-3kx6A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 154
LEU A 158
VAL A 161
LEU A 165
 None
 0.83A 1fbmD-3l0dA:
undetectable		 1fbmD-3l0dA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		4 THR A 272
LEU A 271
VAL A 266
LEU A 264
 None
 0.95A 1fbmD-3lrkA:
undetectable		 1fbmD-3lrkA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 THR A 199
LEU A 203
VAL A 206
LEU A 210
 None
 0.64A 1fbmD-3mmtA:
undetectable		 1fbmD-3mmtA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 THR A 379
LEU A 383
VAL A 386
LEU A 390
 None
 0.41A 1fbmD-3nnkA:
undetectable		 1fbmD-3nnkA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.64A 1fbmD-3nvlA:
undetectable		 1fbmD-3nvlA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 THR B 497
LEU B 501
VAL B 504
LEU B 508
 None
 0.71A 1fbmD-3o8oB:
undetectable		 1fbmD-3o8oB:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 THR A 655
LEU A 654
VAL A 668
LEU A 670
 None
 0.97A 1fbmD-3odwA:
undetectable		 1fbmD-3odwA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		4 THR A 289
LEU A 293
VAL A 296
LEU A 300
 None
 0.72A 1fbmD-3pjxA:
undetectable		 1fbmD-3pjxA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy9 DIHYDRODIPICOLINATE
REDUCTASE

(Staphylococcus
aureus) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 SO4  A 242 (-3.9A)
None
None
None
 0.82A 1fbmD-3qy9A:
undetectable		 1fbmD-3qy9A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		4 THR A 235
LEU A 247
VAL A 250
LEU A 254
 None
 0.71A 1fbmD-3shoA:
undetectable		 1fbmD-3shoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 THR A  75
LEU A  79
VAL A  82
LEU A  86
 None
 0.54A 1fbmD-3slkA:
undetectable		 1fbmD-3slkA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 THR A 149
LEU A 153
VAL A 156
LEU A 160
 None
 0.59A 1fbmD-3un1A:
undetectable		 1fbmD-3un1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		4 THR A 744
LEU A 745
VAL A 748
LEU A 727
 None
 0.87A 1fbmD-3un9A:
undetectable		 1fbmD-3un9A:
7.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)

(Mus musculus) 		PF11598
(COMP) 		4 THR A  40
LEU A  44
VAL A  47
LEU A  51
 STE  A   1 (-4.0A)
STE  A   1 ( 4.5A)
None
STE  A   1 (-4.4A)
 0.49A 1fbmD-3v2pA:
undetectable		 1fbmD-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		4 THR A 138
LEU A 137
VAL A 155
LEU A 158
 None
 0.93A 1fbmD-3w3sA:
undetectable		 1fbmD-3w3sA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 THR A 288
LEU A 291
VAL A 294
LEU A 298
 GOL  A 506 (-4.7A)
GOL  A 506 ( 4.4A)
None
None
 0.90A 1fbmD-3wc3A:
undetectable		 1fbmD-3wc3A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 THR A 184
LEU A 188
VAL A 191
LEU A 195
 None
 0.69A 1fbmD-3zgxA:
undetectable		 1fbmD-3zgxA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 THR A  91
LEU A  95
VAL A  97
LEU A 101
 None
 0.85A 1fbmD-4ak9A:
undetectable		 1fbmD-4ak9A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 THR A 277
LEU A 281
VAL A 284
LEU A 288
 None
 0.68A 1fbmD-4d2jA:
undetectable		 1fbmD-4d2jA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 152
LEU A 156
VAL A 159
LEU A 163
 None
 0.51A 1fbmD-4dibA:
undetectable		 1fbmD-4dibA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE

(Homarus
americanus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR 1 149
LEU 1 153
VAL 1 156
LEU 1 160
 None
 0.81A 1fbmD-4gpd1:
undetectable		 1fbmD-4gpd1:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 THR A 139
LEU A 143
VAL A 146
LEU A 150
 None
 0.34A 1fbmD-4gxbA:
undetectable		 1fbmD-4gxbA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 103
LEU A 107
VAL A 110
LEU A 114
 CL  A 403 (-3.1A)
None
None
None
 0.51A 1fbmD-4h19A:
undetectable		 1fbmD-4h19A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpm BCL-6
COREPRESSOR-LIKE
PROTEIN 1

(Homo sapiens) 		PF16553
(PUFD) 		4 THR A1667
LEU A1666
VAL A1660
LEU A1611
 None
 0.90A 1fbmD-4hpmA:
undetectable		 1fbmD-4hpmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 THR A1105
LEU A1109
VAL A1112
LEU A1117
 None
 0.68A 1fbmD-4igiA:
undetectable		 1fbmD-4igiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeu SYNTAXIN-BINDING
PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 THR A 361
LEU A 365
VAL A 368
LEU A 372
 None
 0.82A 1fbmD-4jeuA:
undetectable		 1fbmD-4jeuA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 THR A 258
LEU A 262
VAL A 265
LEU A 269
 None
 0.56A 1fbmD-4l9aA:
undetectable		 1fbmD-4l9aA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7c TELOMERIC
REPEAT-BINDING
FACTOR 2

(Homo sapiens) 		PF08558
(TRF) 		4 THR A  96
LEU A 100
VAL A 103
LEU A 107
 None
 0.62A 1fbmD-4m7cA:
undetectable		 1fbmD-4m7cA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		4 THR A 190
LEU A 194
VAL A 197
LEU A 202
 None
 0.83A 1fbmD-4oecA:
undetectable		 1fbmD-4oecA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 THR A 684
LEU A 687
VAL A 650
LEU A 653
 None
 0.87A 1fbmD-4ot9A:
undetectable		 1fbmD-4ot9A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 THR A  28
LEU A  31
VAL A  34
LEU A  38
 None
 0.50A 1fbmD-4oy4A:
undetectable		 1fbmD-4oy4A:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 THR F  12
LEU F  16
VAL F  19
LEU F  23
 None
 0.71A 1fbmD-4p6vF:
undetectable		 1fbmD-4p6vF:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq0 FACT COMPLEX SUBUNIT
POB3

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 THR A 353
LEU A 357
VAL A 360
LEU A 364
 None
 0.49A 1fbmD-4pq0A:
undetectable		 1fbmD-4pq0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxj C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 3

(Homo sapiens) 		PF16471
(JIP_LZII) 		4 THR A 433
LEU A 437
VAL A 440
LEU A 444
 None
 0.78A 1fbmD-4pxjA:
undetectable		 1fbmD-4pxjA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 THR A 463
LEU A 467
VAL A 470
LEU A 474
 None
 0.57A 1fbmD-4q65A:
undetectable		 1fbmD-4q65A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfs SUBSTRATE BINDING
PRITEIN S

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		4 THR S 132
LEU S 136
VAL S 139
LEU S 164
 None
 0.87A 1fbmD-4rfsS:
undetectable		 1fbmD-4rfsS:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 THR A 212
LEU A 216
VAL A 219
LEU A 223
 None
 0.64A 1fbmE-1a5cA:
undetectable		 1fbmE-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bct BACTERIORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 THR A 170
LEU A 174
VAL A 177
LEU A 181
 None
 0.85A 1fbmE-1bctA:
1.7		 1fbmE-1bctA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 THR A 170
LEU A 174
VAL A 177
LEU A 181
 None
 0.75A 1fbmE-1brrA:
0.0		 1fbmE-1brrA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 THR A  95
LEU A 220
LEU A  60
GLN A  56
 None
 0.90A 1fbmE-1cbyA:
undetectable		 1fbmE-1cbyA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 LEU A  75
VAL A  79
LEU A  83
GLN A  86
 None
 0.69A 1fbmE-1ehkA:
0.0		 1fbmE-1ehkA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.48A 1fbmE-1fbaA:
undetectable		 1fbmE-1fbaA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.49A 1fbmE-1fdjA:
undetectable		 1fbmE-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he9 EXOENZYME S

(Pseudomonas
aeruginosa) 		PF03545
(YopE) 		5 THR A 207
LEU A 210
VAL A 213
LEU A 171
GLN A 167
 None
 1.46A 1fbmE-1he9A:
undetectable		 1fbmE-1he9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		4 LEU A 259
VAL A 262
LEU A 266
GLN A 269
 None
 0.59A 1fbmE-1jbkA:
undetectable		 1fbmE-1jbkA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A  39
VAL A  22
LEU A  65
GLN A 107
 None
 0.78A 1fbmE-1loxA:
undetectable		 1fbmE-1loxA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		4 THR A  67
LEU A  71
LEU A  78
GLN A  81
 None
 0.69A 1fbmE-1lpeA:
undetectable		 1fbmE-1lpeA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE

(Homo sapiens) 		PF01182
(Glucosamine_iso) 		4 THR A  68
LEU A  39
VAL A 135
LEU A 202
 None
 0.77A 1fbmE-1ne7A:
undetectable		 1fbmE-1ne7A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nks ADENYLATE KINASE

(Sulfolobus
acidocaldarius) 		PF13207
(AAA_17) 		4 LEU A  18
VAL A  21
LEU A  25
GLN A  28
 None
 0.87A 1fbmE-1nksA:
undetectable		 1fbmE-1nksA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1org PHEROMONE BINDING
PROTEIN

(Rhyparobia
maderae) 		PF01395
(PBP_GOBP) 		4 THR A  63
LEU A  67
VAL A  70
LEU A  74
 None
 0.91A 1fbmE-1orgA:
undetectable		 1fbmE-1orgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.68A 1fbmE-1r6aA:
undetectable		 1fbmE-1r6aA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 THR A 176
LEU A 143
VAL A  78
LEU A 103
GLN A 127
 None
 0.92A 1fbmE-1r6aA:
undetectable		 1fbmE-1r6aA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		4 LEU A 253
VAL A 252
LEU A  85
GLN A  84
 None
 0.90A 1fbmE-1rajA:
undetectable		 1fbmE-1rajA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr2 PUTATIVE SENSOR-LIKE
HISTIDINE KINASE
YOJN

(Escherichia
coli) 		PF01627
(Hpt) 		4 THR A 840
LEU A 844
VAL A 847
LEU A 851
 None
 0.67A 1fbmE-1sr2A:
undetectable		 1fbmE-1sr2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		4 LEU A 551
VAL A 510
LEU A 518
GLN A 586
 None
 0.87A 1fbmE-1suuA:
undetectable		 1fbmE-1suuA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		4 LEU A  88
VAL A  91
LEU A  95
GLN A  98
 None
 0.70A 1fbmE-1td6A:
undetectable		 1fbmE-1td6A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 LEU A 254
VAL A 253
LEU A  85
GLN A  84
 None
 0.90A 1fbmE-1tp7A:
undetectable		 1fbmE-1tp7A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.84A 1fbmE-1u6gC:
undetectable		 1fbmE-1u6gC:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 THR A  35
LEU A  39
VAL A  42
LEU A  46
 None
 0.46A 1fbmE-1ufaA:
undetectable		 1fbmE-1ufaA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 150
LEU A 154
VAL A 157
LEU A 161
 None
 0.59A 1fbmE-1vc2A:
undetectable		 1fbmE-1vc2A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhz ADP COMPOUNDS
HYDROLASE NUDE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 LEU A 173
VAL A 176
LEU A 180
GLN A 183
 None
 0.86A 1fbmE-1vhzA:
undetectable		 1fbmE-1vhzA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.79A 1fbmE-1w55A:
undetectable		 1fbmE-1w55A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A2193
LEU A2197
VAL A2200
LEU A2204
 None
 0.76A 1fbmE-1wchA:
undetectable		 1fbmE-1wchA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.69A 1fbmE-1wekA:
undetectable		 1fbmE-1wekA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		4 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.49A 1fbmE-1xfbA:
undetectable		 1fbmE-1xfbA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		4 THR A 160
LEU A 164
VAL A 167
LEU A 171
 None
 0.72A 1fbmE-1y9uA:
undetectable		 1fbmE-1y9uA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		4 THR A  85
LEU A  89
VAL A  92
LEU A  96
 None
 0.48A 1fbmE-1yulA:
undetectable		 1fbmE-1yulA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq3 HOMEOTIC BICOID
PROTEIN

(Drosophila
melanogaster) 		PF00046
(Homeobox) 		5 THR P  28
LEU P  27
VAL P  46
LEU P  17
GLN P  13
 None
 1.46A 1fbmE-1zq3P:
undetectable		 1fbmE-1zq3P:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		4 THR A  51
LEU A 132
VAL A 127
LEU A 100
 None
 0.91A 1fbmE-1zy9A:
undetectable		 1fbmE-1zy9A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.67A 1fbmE-2a9sA:
undetectable		 1fbmE-2a9sA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K

(Enterococcus
hirae) 		PF00137
(ATP-synt_C) 		4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.71A 1fbmE-2bl2A:
undetectable		 1fbmE-2bl2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2

(Homo sapiens) 		PF00564
(PB1) 		4 LEU A  71
VAL A  68
LEU A  64
GLN A  61
 None
 0.89A 1fbmE-2cu1A:
undetectable		 1fbmE-2cu1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 156
LEU A 160
VAL A 163
LEU A 167
 SO4  A1339 ( 4.3A)
None
None
None
 0.61A 1fbmE-2d2iA:
undetectable		 1fbmE-2d2iA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		4 LEU A 372
VAL A 375
LEU A 379
GLN A 382
 None
 0.57A 1fbmE-2dr1A:
undetectable		 1fbmE-2dr1A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2a PROTEIN (ENZYME IIA)

(Lactococcus
lactis) 		PF02255
(PTS_IIA) 		4 THR A  85
LEU A  89
VAL A  92
LEU A  96
 None
 0.84A 1fbmE-2e2aA:
undetectable		 1fbmE-2e2aA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm5 TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase) 		4 LEU A  23
VAL A  20
LEU A  16
GLN A  13
 None
 0.88A 1fbmE-2gm5A:
undetectable		 1fbmE-2gm5A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		4 THR A 103
LEU A 107
VAL A 110
LEU A 114
 None
 0.77A 1fbmE-2hujA:
undetectable		 1fbmE-2hujA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihm DNA POLYMERASE MU

(Mus musculus) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 LEU A 347
VAL A 350
LEU A 354
GLN A 357
 None
 0.64A 1fbmE-2ihmA:
undetectable		 1fbmE-2ihmA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		4 LEU A 268
VAL A 265
LEU A 261
GLN A 252
 None
None
None
SAH  A1406 (-4.1A)
 0.82A 1fbmE-2jjqA:
undetectable		 1fbmE-2jjqA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0m MINOR AMPULLATE
FIBROIN 1

(Nephila
antipodiana) 		PF11260
(Spidroin_MaSp) 		5 THR A  52
LEU A  55
VAL A  58
LEU A  62
GLN A  65
 None
 1.22A 1fbmE-2m0mA:
undetectable		 1fbmE-2m0mA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN-6

(Homo sapiens) 		no annotation 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.71A 1fbmE-2npsD:
3.8		 1fbmE-2npsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 2

(Homo sapiens) 		PF00564
(PB1) 		4 LEU B 106
VAL B 103
LEU B  99
GLN B  96
 None
 0.88A 1fbmE-2nptB:
undetectable		 1fbmE-2nptB:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS) 		4 THR A 158
LEU A 162
LEU A 169
GLN A 172
 None
 0.85A 1fbmE-2o3bA:
undetectable		 1fbmE-2o3bA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		4 THR A  83
LEU A  87
VAL A  90
LEU A  94
 None
 0.80A 1fbmE-2o42A:
undetectable		 1fbmE-2o42A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 THR A  36
LEU A  40
VAL A  42
LEU A  46
 None
 0.68A 1fbmE-2og2A:
undetectable		 1fbmE-2og2A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 113
LEU A 117
VAL A 120
LEU A 124
 None
 0.62A 1fbmE-2okjA:
undetectable		 1fbmE-2okjA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 107
LEU A 111
VAL A 114
LEU A 118
 None
 0.72A 1fbmE-2okkA:
undetectable		 1fbmE-2okkA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.64A 1fbmE-2oy0A:
undetectable		 1fbmE-2oy0A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		4 THR A 120
LEU A 124
VAL A 127
LEU A 131
 ADP  A 300 (-3.6A)
None
None
None
 0.75A 1fbmE-2pl3A:
undetectable		 1fbmE-2pl3A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.73A 1fbmE-2px5A:
undetectable		 1fbmE-2px5A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qop HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ACRR

(Escherichia
coli) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 THR A  12
VAL A  19
LEU A  23
GLN A  26
 None
 0.86A 1fbmE-2qopA:
undetectable		 1fbmE-2qopA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rci TYPE-2BA CYTOLYTIC
DELTA-ENDOTOXIN

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 THR A  95
LEU A 220
LEU A  60
GLN A  56
 THR  A  95 ( 0.8A)
LEU  A 220 ( 0.6A)
LEU  A  60 ( 0.5A)
GLN  A  56 ( 0.6A)
 0.74A 1fbmE-2rciA:
undetectable		 1fbmE-2rciA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2spc SPECTRIN

(Drosophila
melanogaster) 		PF00435
(Spectrin) 		4 LEU A  61
VAL A  64
LEU A  68
GLN A  71
 None
 0.80A 1fbmE-2spcA:
2.7		 1fbmE-2spcA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 301
VAL A 304
LEU A 308
GLN A 313
 None
 0.89A 1fbmE-2vqrA:
undetectable		 1fbmE-2vqrA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqx METALLOPROTEINASE

(Serratia
proteamaculans) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
PF16485
(PLN_propep) 		4 LEU A 188
VAL A 191
LEU A 195
GLN A 198
 None
 0.88A 1fbmE-2vqxA:
undetectable		 1fbmE-2vqxA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w83 C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 4

(Homo sapiens) 		PF16471
(JIP_LZII) 		4 THR C 409
LEU C 413
VAL C 416
LEU C 420
 None
 0.53A 1fbmE-2w83C:
3.8		 1fbmE-2w83C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 414
VAL A 497
LEU A 390
GLN A 380
 None
 0.80A 1fbmE-2wtzA:
undetectable		 1fbmE-2wtzA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvw RBCX PROTEIN

(Anabaena sp. CA
= ATCC 33047) 		PF02341
(RcbX) 		4 THR I  19
LEU I  23
VAL I  26
LEU I  30
 None
 0.85A 1fbmE-2wvwI:
undetectable		 1fbmE-2wvwI:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		4 LEU A 198
VAL A 195
LEU A 191
GLN A 188
 None
 0.81A 1fbmE-2x9pA:
undetectable		 1fbmE-2x9pA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 THR J  27
LEU J  31
VAL J  34
LEU J  38
 None
 0.50A 1fbmE-2y69J:
2.6		 1fbmE-2y69J:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zd2 ATP12 ATPASE

(Paracoccus
denitrificans) 		PF07542
(ATP12) 		4 THR A1046
LEU A1044
VAL A1027
LEU A1034
 None
 0.87A 1fbmE-2zd2A:
undetectable		 1fbmE-2zd2A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II
REACTION CENTER
PROTEIN I

(Thermosynechococcus
vulcanus) 		PF02532
(PsbI) 		4 THR I  13
LEU I  17
VAL I  20
LEU I  24
 None
 0.71A 1fbmE-3a0hI:
2.3		 1fbmE-3a0hI:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 THR B 237
LEU B 240
LEU B 247
GLN B 250
 None
 0.74A 1fbmE-3aqcB:
undetectable		 1fbmE-3aqcB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b02 TRANSCRIPTIONAL
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 LEU A  86
VAL A  89
LEU A  93
GLN A  96
 None
 0.68A 1fbmE-3b02A:
undetectable		 1fbmE-3b02A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 156
LEU A 160
VAL A 163
LEU A 167
 SO4  A1339 (-3.7A)
None
None
None
 0.59A 1fbmE-3b20A:
undetectable		 1fbmE-3b20A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 THR A 243
LEU A 247
VAL A 250
LEU A 254
 HEM  A 450 (-4.3A)
None
None
None
 0.62A 1fbmE-3bdzA:
undetectable		 1fbmE-3bdzA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.55A 1fbmE-3bv4A:
undetectable		 1fbmE-3bv4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 THR A 247
LEU A 251
VAL A 254
LEU A 258
 None
 0.72A 1fbmE-3c8tA:
undetectable		 1fbmE-3c8tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 THR A 136
LEU A 140
VAL A 143
LEU A 147
 None
 0.56A 1fbmE-3cj1A:
undetectable		 1fbmE-3cj1A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl3 ORF K13

(Human
gammaherpesvirus
8) 		PF01335
(DED) 		4 THR A   3
LEU A   7
VAL A  10
LEU A  14
 None
 0.82A 1fbmE-3cl3A:
undetectable		 1fbmE-3cl3A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.55A 1fbmE-3cskA:
undetectable		 1fbmE-3cskA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 154
LEU A 158
VAL A 161
LEU A 165
 None
 0.54A 1fbmE-3docA:
undetectable		 1fbmE-3docA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwm 9.5 KDA CULTURE
FILTRATE ANTIGEN
CFP10A

(Mycobacterium
tuberculosis) 		PF02597
(ThiS) 		4 THR A  76
LEU A  28
VAL A  31
LEU A  35
 None
 0.54A 1fbmE-3dwmA:
undetectable		 1fbmE-3dwmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 THR A 147
LEU A 151
VAL A 154
GLN A 161
 None
 0.92A 1fbmE-3e97A:
undetectable		 1fbmE-3e97A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 THR A 147
VAL A 154
LEU A 158
GLN A 161
 None
 0.87A 1fbmE-3e97A:
undetectable		 1fbmE-3e97A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		4 LEU A  79
VAL A  82
LEU A  86
GLN A  89
 None
 0.72A 1fbmE-3ek5A:
undetectable		 1fbmE-3ek5A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.67A 1fbmE-3evcA:
undetectable		 1fbmE-3evcA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6p TRANSCRIPTIONAL
REGULATORY PROTEIN
YYCF

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 THR A 106
LEU A 110
VAL A 113
LEU A 117
 None
 0.68A 1fbmE-3f6pA:
undetectable		 1fbmE-3f6pA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g87 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		4 THR A 109
LEU A 113
LEU A 120
GLN A 123
 None
 0.84A 1fbmE-3g87A:
undetectable		 1fbmE-3g87A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 THR A 211
LEU A 215
VAL A 218
LEU A 222
 GOL  A 283 ( 4.7A)
None
None
None
 0.74A 1fbmE-3h74A:
undetectable		 1fbmE-3h74A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvw DIGUANYLATE-CYCLASE
(DGC)

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 THR A 238
LEU A 250
VAL A 196
LEU A 292
 None
 0.81A 1fbmE-3hvwA:
undetectable		 1fbmE-3hvwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.68A 1fbmE-3ibrA:
undetectable		 1fbmE-3ibrA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iee PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		no annotation 4 LEU A 145
VAL A 148
LEU A 152
GLN A 155
 None
 0.59A 1fbmE-3ieeA:
undetectable		 1fbmE-3ieeA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 389
VAL A 392
LEU A 396
GLN A 399
 None
 0.80A 1fbmE-3ifqA:
undetectable		 1fbmE-3ifqA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A 536
VAL A 539
LEU A 543
GLN A 546
 None
 0.88A 1fbmE-3k30A:
undetectable		 1fbmE-3k30A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 4 THR Q 152
LEU Q 156
VAL Q 159
LEU Q 163
 None
 0.57A 1fbmE-3ksdQ:
undetectable		 1fbmE-3ksdQ:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.51A 1fbmE-3kx6A:
undetectable		 1fbmE-3kx6A:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 154
LEU A 158
VAL A 161
LEU A 165
 None
 0.63A 1fbmE-3l0dA:
undetectable		 1fbmE-3l0dA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhq ACRAB OPERON
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 THR A  12
VAL A  19
LEU A  23
GLN A  26
 None
 0.69A 1fbmE-3lhqA:
undetectable		 1fbmE-3lhqA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 THR A 161
LEU A 165
VAL A 168
LEU A 172
 None
 0.60A 1fbmE-3lkzA:
undetectable		 1fbmE-3lkzA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 THR A 199
LEU A 203
VAL A 206
LEU A 210
 None
 0.59A 1fbmE-3mmtA:
undetectable		 1fbmE-3mmtA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 THR A 379
LEU A 383
VAL A 386
LEU A 390
 None
 0.58A 1fbmE-3nnkA:
undetectable		 1fbmE-3nnkA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.57A 1fbmE-3nvlA:
undetectable		 1fbmE-3nvlA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 THR B 497
LEU B 501
VAL B 504
LEU B 508
 None
 0.87A 1fbmE-3o8oB:
undetectable		 1fbmE-3o8oB:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 THR A 493
LEU A 497
LEU A 504
GLN A 507
 None
 0.57A 1fbmE-3ojaA:
4.0		 1fbmE-3ojaA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 LEU A  56
VAL A 256
LEU A 260
GLN A 263
 None
 0.78A 1fbmE-3op7A:
undetectable		 1fbmE-3op7A:
9.19