SIMILAR PATTERNS OF AMINO ACIDS FOR 1FB7_A_ROCA100_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

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	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ALA A 28 ASP A 29 GLY A 48 THR A 80 PRO A 81 VAL A 82 ILE A 84	A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 (-4.1A) None A79 A 800 ( 3.4A) A79 A 800 (-4.5A) A79 A 800 (-3.8A)	0.69A	1fb7A-1hvcA: 13.8	1fb7A-1hvcA: 47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ALA A 28 ASP A 29 GLY A 48 THR A 80 VAL A 82 ILE A 84	A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 (-3.6A) None A79 A 800 (-4.5A) A79 A 800 (-3.6A)	0.67A	1fb7A-1hvcA: 13.8	1fb7A-1hvcA: 47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	11	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 THR A 80 PRO A 81 VAL A 82 ILE A 84	A79 A 800 (-2.7A) A79 A 800 (-3.0A) A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 ( 4.9A) A79 A 800 ( 3.7A) A79 A 800 (-3.8A) None A79 A 800 ( 3.9A) A79 A 800 (-4.5A) A79 A 800 (-3.6A)	0.40A	1fb7A-1hvcA: 13.8	1fb7A-1hvcA: 47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 THR A 80 VAL A 82 ILE A 84	A79 A 800 (-2.8A) A79 A 800 (-3.0A) A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 ( 4.7A) A79 A 800 (-3.4A) A79 A 800 ( 4.0A) None A79 A 800 (-4.5A) A79 A 800 (-3.8A)	0.44A	1fb7A-1hvcA: 13.8	1fb7A-1hvcA: 47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 THR A 80 PRO A 81 VAL A 82 ILE A 84	A79 A 800 (-2.8A) A79 A 800 (-3.0A) A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 ( 4.7A) A79 A 800 (-3.4A) None A79 A 800 ( 3.4A) A79 A 800 (-4.5A) A79 A 800 (-3.8A)	0.40A	1fb7A-1hvcA: 13.8	1fb7A-1hvcA: 47.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1imv	PIGMENT EPITHELIUM-DERIVED FACTOR (Homo sapiens)	PF00079 (Serpin)	5	ASP A 156 VAL A 148 ILE A 122 VAL A 164 ILE A 160	None	0.90A	1fb7A-1imvA: undetectable	1fb7A-1imvA: 12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1m0s	RIBOSE-5-PHOSPHATE ISOMERASE A (Haemophilus influenzae)	PF06026 (Rib_5-P_isom_A)	5	GLY A 97 ALA A 98 GLY A 197 ILE A 93 ILE A 169	CIT A 501 (-3.1A) None None None None	1.01A	1fb7A-1m0sA: undetectable	1fb7A-1m0sA: 18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1o5w	AMINE OXIDASE [FLAVIN-CONTAINING] A (Rattus norvegicus)	PF01593 (Amino_oxidase)	5	ASP A 64 GLY A 222 VAL A 48 GLY A 49 ILE A 23	None None None None FAD A 652 (-4.8A)	0.87A	1fb7A-1o5wA: undetectable	1fb7A-1o5wA: 10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1p2f	RESPONSE REGULATOR (Thermotoga maritima)	PF00072 (Response_reg) PF00486 (Trans_reg_C)	5	GLY A 93 ALA A 94 ASP A 95 ILE A 61 THR A 78	None	0.85A	1fb7A-1p2fA: undetectable	1fb7A-1p2fA: 18.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1q9p	HIV-1 PROTEASE (Homo sapiens)	PF00077 (RVP)	7	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 THR A 80 ILE A 84	None	0.49A	1fb7A-1q9pA: 10.5	1fb7A-1q9pA: 91.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1q9p	HIV-1 PROTEASE (Homo sapiens)	PF00077 (RVP)	7	ASP A 25 GLY A 27 ALA A 28 ASP A 30 THR A 80 PRO A 81 ILE A 84	None	0.68A	1fb7A-1q9pA: 10.5	1fb7A-1q9pA: 91.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	5	ALA A 28 GLY A 48 THR A 80 PRO A 81 ILE A 84	None	0.57A	1fb7A-1sivA: 18.1	1fb7A-1sivA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	5	ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None	1.00A	1fb7A-1sivA: 18.1	1fb7A-1sivA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	10	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 THR A 80 PRO A 81 ILE A 84	None	0.48A	1fb7A-1sivA: 18.1	1fb7A-1sivA: 48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1tjr	BX1 (Zea mays)	PF00290 (Trp_syntA)	5	GLY A 307 ALA A 308 ASP A 309 VAL A 269 ILE A 303	None	0.81A	1fb7A-1tjrA: undetectable	1fb7A-1tjrA: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uxi	MALATE DEHYDROGENASE (Chloroflexus aurantiacus)	PF00056 (Ldh_1_N) PF02866 (Ldh_1_C)	5	ALA A 169 VAL A 146 GLY A 145 THR A 209 VAL A 206	None	1.02A	1fb7A-1uxiA: undetectable	1fb7A-1uxiA: 15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vrg	PROPIONYL-COA CARBOXYLASE, BETA SUBUNIT (Thermotoga maritima)	PF01039 (Carboxyl_trans)	5	GLY A 416 ALA A 417 ASP A 418 ILE A 346 VAL A 360	None	0.84A	1fb7A-1vrgA: undetectable	1fb7A-1vrgA: 11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1w3f	HEMOLYTIC LECTIN FROM LAETIPORUS SULPHUREUS (Laetiporus sulphureus)	PF03318 (ETX_MTX2)	5	GLY A 241 GLY A 296 ILE A 297 PRO A 221 VAL A 220	None	0.91A	1fb7A-1w3fA: undetectable	1fb7A-1w3fA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wl4	ACETYL-COENZYME A ACETYLTRANSFERASE 2 (Homo sapiens)	PF00108 (Thiolase_N) PF02803 (Thiolase_C)	5	ALA A 381 VAL A 394 GLY A 378 ILE A 317 ILE A 301	None	0.85A	1fb7A-1wl4A: undetectable	1fb7A-1wl4A: 13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1x0u	HYPOTHETICAL METHYLMALONYL-COA DECARBOXYLASE ALPHA SUBUNIT (Sulfurisphaera tokodaii)	PF01039 (Carboxyl_trans)	5	GLY A 424 ALA A 425 ASP A 426 ILE A 354 VAL A 368	None	0.84A	1fb7A-1x0uA: undetectable	1fb7A-1x0uA: 11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2fmb	EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE (Equine infectious anemia virus)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 GLY A 55 PRO A 86 VAL A 87 ILE A 89	LP1 A 201 (-2.3A) LP1 A 201 (-3.8A) LP1 A 201 (-3.5A) LP1 A 201 (-3.6A) LP1 A 201 (-3.4A) LP1 A 201 (-3.9A) LP1 A 201 ( 4.9A) LP1 A 201 (-4.2A)	0.38A	1fb7A-2fmbA: 15.2	1fb7A-2fmbA: 29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ics	ADENINE DEAMINASE (Enterococcus faecalis)	PF01979 (Amidohydro_1)	5	ASP A 330 VAL A 79 GLY A 78 ILE A 77 ILE A 57	None	0.92A	1fb7A-2icsA: undetectable	1fb7A-2icsA: 14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2isq	CYSTEINE SYNTHASE (Arabidopsis thaliana)	PF00291 (PALP)	5	GLY A 190 ALA A 189 GLY A 183 ILE A 180 PRO A 296	None None PLP A 400 (-3.4A) PLP A 400 (-4.9A) PLP A 400 (-4.0A)	0.81A	1fb7A-2isqA: undetectable	1fb7A-2isqA: 15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2obv	S-ADENOSYLMETHIONINE SYNTHETASE ISOFORM TYPE-1 (Homo sapiens)	PF00438 (S-AdoMet_synt_N) PF02772 (S-AdoMet_synt_M) PF02773 (S-AdoMet_synt_C)	5	GLY A 260 ASP A 35 GLY A 28 THR A 86 VAL A 83	None	0.94A	1fb7A-2obvA: undetectable	1fb7A-2obvA: 15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ALA A 28 ASP A 29 GLY A 48 THR A 80 PRO A 81 ILE A 84	AB1 A 501 (-3.5A) AB1 A 501 ( 3.3A) AB1 A 501 (-4.2A) None AB1 A 501 (-4.2A) AB1 A 501 ( 4.2A)	0.69A	1fb7A-2rkfA: 20.5	1fb7A-2rkfA: 84.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 THR A 80 ILE A 84	AB1 A 501 (-2.4A) AB1 A 501 (-3.9A) AB1 A 501 (-3.5A) AB1 A 501 ( 3.3A) AB1 A 501 (-3.8A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A) None AB1 A 501 ( 4.2A)	0.32A	1fb7A-2rkfA: 20.5	1fb7A-2rkfA: 84.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 ILE A 50 THR A 80 PRO A 81 ILE A 84	AB1 A 501 (-2.4A) AB1 A 501 (-3.9A) AB1 A 501 (-3.5A) AB1 A 501 ( 3.3A) AB1 A 501 (-3.8A) AB1 A 501 (-3.8A) None AB1 A 501 (-4.2A) AB1 A 501 ( 4.2A)	0.46A	1fb7A-2rkfA: 20.5	1fb7A-2rkfA: 84.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rsp	RSV PROTEASE (Rous sarcoma virus)	PF00077 (RVP)	5	ASP A 37 GLY A 39 ALA A 40 ASP A 41 ILE A 108	None	0.32A	1fb7A-2rspA: 12.6	1fb7A-2rspA: 32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2v6c	PROLIFERATION-ASSOCI ATED PROTEIN 2G4 (Mus musculus)	PF00557 (Peptidase_M24)	5	ASP A 53 GLY A 52 VAL A 121 PRO A 277 ILE A 74	None	1.00A	1fb7A-2v6cA: undetectable	1fb7A-2v6cA: 13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2vn8	RETICULON-4-INTERACT ING PROTEIN 1 (Homo sapiens)	PF08240 (ADH_N) PF13602 (ADH_zinc_N_2)	5	GLY A 248 ALA A 249 ASP A 250 ASP A 251 VAL A 208	None	0.80A	1fb7A-2vn8A: undetectable	1fb7A-2vn8A: 14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yb4	AMIDOHYDROLASE (Chromobacterium violaceum)	PF02811 (PHP)	5	GLY A 182 ALA A 183 THR A 42 VAL A 63 ILE A 81	None	1.02A	1fb7A-2yb4A: undetectable	1fb7A-2yb4A: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z5x	AMINE OXIDASE [FLAVIN-CONTAINING] A (Homo sapiens)	PF01593 (Amino_oxidase)	5	ASP A 64 GLY A 222 VAL A 48 GLY A 49 ILE A 23	GOL A 702 (-3.6A) GOL A 702 (-3.6A) None FAD A 600 (-4.9A) FAD A 600 (-4.9A)	0.88A	1fb7A-2z5xA: undetectable	1fb7A-2z5xA: 12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zxo	SINGLE-STRANDED DNA SPECIFIC EXONUCLEASE RECJ (Thermus thermophilus)	PF01368 (DHH) PF02272 (DHHA1)	5	GLY A 187 ALA A 188 VAL A 233 PRO A 207 ILE A 91	None	0.97A	1fb7A-2zxoA: undetectable	1fb7A-2zxoA: 9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3any	ETHANOLAMINE AMMONIA-LYASE HEAVY CHAIN (Escherichia coli)	PF06751 (EutB)	5	ASP A 214 ASP A 207 GLY A 241 THR A 220 ILE A 213	None	1.00A	1fb7A-3anyA: undetectable	1fb7A-3anyA: 12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3c3k	ALANINE RACEMASE (Actinobacillus succinogenes)	PF13377 (Peripla_BP_3)	5	GLY A 198 ALA A 197 VAL A 217 GLY A 218 ILE A 224	None	0.98A	1fb7A-3c3kA: undetectable	1fb7A-3c3kA: 15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gve	YFKN PROTEIN (Bacillus subtilis)	PF00149 (Metallophos)	5	GLY A 121 ALA A 122 ASP A 123 ILE A 89 ILE A 126	None	0.74A	1fb7A-3gveA: undetectable	1fb7A-3gveA: 15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3h1l	MITOCHONDRIAL UBIQUINOL-CYTOCHROME -C REDUCTASE COMPLEX CORE PROTEIN 2 (Gallus gallus)	PF00675 (Peptidase_M16) PF05193 (Peptidase_M16_C)	5	ALA B 36 VAL B 49 GLY B 48 ILE B 47 ILE B 382	None	0.93A	1fb7A-3h1lB: undetectable	1fb7A-3h1lB: 14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3hdf	LYSOZYME (Escherichia virus Lambda)	PF00959 (Phage_lysozyme)	5	ALA A 131 ASP A 127 GLY A 163 PRO A 95 ILE A 123	None	1.00A	1fb7A-3hdfA: undetectable	1fb7A-3hdfA: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i5g	MYOSIN HEAVY CHAIN ISOFORM A (Doryteuthis pealeii)	PF00063 (Myosin_head) PF00612 (IQ) PF02736 (Myosin_N)	5	ALA A 265 ASP A 266 GLY A 460 ILE A 459 ILE A 224	None	0.96A	1fb7A-3i5gA: undetectable	1fb7A-3i5gA: 8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i5g	MYOSIN HEAVY CHAIN ISOFORM A (Doryteuthis pealeii)	PF00063 (Myosin_head) PF00612 (IQ) PF02736 (Myosin_N)	5	GLY A 264 ALA A 265 ASP A 266 GLY A 460 ILE A 459	None	0.83A	1fb7A-3i5gA: undetectable	1fb7A-3i5gA: 8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3j2i	PROLIFERATION-ASSOCI ATED PROTEIN 2G4 (Homo sapiens)	PF00557 (Peptidase_M24)	5	ASP A 53 GLY A 52 VAL A 121 PRO A 277 ILE A 74	None	1.01A	1fb7A-3j2iA: undetectable	1fb7A-3j2iA: 13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3kvo	HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2 (Homo sapiens)	PF00106 (adh_short)	5	GLY A 128 ASP A 74 GLY A 17 VAL A 85 ILE A 81	None NAP A 501 (-3.5A) NAP A 501 (-3.3A) None None	0.95A	1fb7A-3kvoA: undetectable	1fb7A-3kvoA: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mwc	MANDELATE RACEMASE/MUCONATE LACTONIZING PROTEIN (Kosmotoga olearia)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	GLY A 310 ALA A 336 ASP A 337 VAL A 363 ILE A 149	None	1.01A	1fb7A-3mwcA: undetectable	1fb7A-3mwcA: 12.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ALA A 28 ASP A 30 GLY A 48 THR A 80 PRO A 81 VAL A 82	None	0.76A	1fb7A-3mwsA: 19.3	1fb7A-3mwsA: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 THR A 80 PRO A 81 VAL A 82 ILE A 84	None	0.61A	1fb7A-3mwsA: 19.3	1fb7A-3mwsA: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 GLY A 49 ILE A 50 THR A 80 VAL A 82 ILE A 84	None	0.54A	1fb7A-3mwsA: 19.3	1fb7A-3mwsA: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 GLY A 49 THR A 80 PRO A 81 VAL A 82 ILE A 84	None	0.59A	1fb7A-3mwsA: 19.3	1fb7A-3mwsA: 75.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nep	MALATE DEHYDROGENASE (Salinibacter ruber)	PF00056 (Ldh_1_N) PF02866 (Ldh_1_C)	5	ALA X 189 VAL X 166 GLY X 165 THR X 231 VAL X 228	None	0.94A	1fb7A-3nepX: undetectable	1fb7A-3nepX: 15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3nns	DNA BINDING RESPONSE REGULATOR B (Thermotoga maritima)	PF00072 (Response_reg)	5	GLY A 93 ALA A 94 ASP A 95 ILE A 61 THR A 78	None None None None BEF A 402 (-3.6A)	0.82A	1fb7A-3nnsA: undetectable	1fb7A-3nnsA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o8o	6-PHOSPHOFRUCTOKINAS E SUBUNIT ALPHA (Saccharomyces cerevisiae)	PF00365 (PFK)	5	GLY A 414 ALA A 415 ASP A 416 VAL A 397 ILE A 452	None	0.93A	1fb7A-3o8oA: undetectable	1fb7A-3o8oA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3opy	6-PHOSPHOFRUCTO-1-KI NASE ALPHA-SUBUNIT (Komagataella pastoris)	PF00365 (PFK)	5	GLY A 419 ALA A 420 ASP A 421 VAL A 402 ILE A 457	None	0.83A	1fb7A-3opyA: undetectable	1fb7A-3opyA: 8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3r8y	2,3,4,5-TETRAHYDROPY RIDINE-2,6-DICARBOXY LATE N-ACETYLTRANSFERASE (Bacillus anthracis)	PF00132 (Hexapep) PF08503 (DapH_N) PF14602 (Hexapep_2)	5	ALA A 92 ASP A 108 GLY A 89 VAL A 104 ILE A 106	None	1.01A	1fb7A-3r8yA: undetectable	1fb7A-3r8yA: 18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slz	GAG-PRO-POL POLYPROTEIN (Murine leukemia virus)	PF00077 (RVP)	5	ASP A 32 GLY A 34 ALA A 35 GLY A 56 PRO A 89	3TL A 126 (-2.4A) 3TL A 126 (-3.1A) 3TL A 126 ( 4.0A) 3TL A 126 (-3.4A) 3TL A 126 (-4.0A)	0.66A	1fb7A-3slzA: 11.3	1fb7A-3slzA: 26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 29 ASP A 30 THR A 80 PRO A 81	017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) None None	0.42A	1fb7A-3t3cA: 18.0	1fb7A-3t3cA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50	017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) 017 A 201 (-4.0A) 017 A 201 (-3.3A)	0.31A	1fb7A-3t3cA: 18.0	1fb7A-3t3cA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 THR A 80	017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) None	0.39A	1fb7A-3t3cA: 18.0	1fb7A-3t3cA: 77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50 THR A 80 ILE A 84	017 A 201 (-2.6A) 017 A 201 (-3.6A) 017 A 201 (-3.4A) 017 A 201 (-3.3A) 017 A 201 (-4.6A) 017 A 201 (-3.0A) 017 A 201 (-3.3A) None 017 A 201 (-4.7A)	0.59A	1fb7A-3ttpA: 19.1	1fb7A-3ttpA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 THR A 80 PRO A 81 ILE A 84	017 A 201 (-2.6A) 017 A 201 (-3.6A) 017 A 201 (-3.4A) 017 A 201 (-3.3A) 017 A 201 (-4.6A) 017 A 201 (-3.0A) None 017 A 201 (-4.1A) 017 A 201 (-4.7A)	0.54A	1fb7A-3ttpA: 19.1	1fb7A-3ttpA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ASP A 29 ASP A 30 GLY A 48 THR A 80 PRO A 81	017 A 201 (-3.3A) 017 A 201 (-4.6A) None None 017 A 201 (-4.1A)	0.74A	1fb7A-3ttpA: 19.1	1fb7A-3ttpA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 50	017 A 202 ( 2.5A) 017 A 201 ( 3.5A) 017 A 201 (-3.4A) 017 A 201 (-3.2A) 017 A 201 ( 4.0A) 017 A 202 (-2.9A) 017 A 201 ( 3.5A)	0.34A	1fb7A-3u7sA: 19.7	1fb7A-3u7sA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 THR A 80 PRO A 81	017 A 202 ( 2.5A) 017 A 201 ( 3.5A) 017 A 201 (-3.4A) 017 A 201 (-3.2A) 017 A 201 ( 4.0A) 017 A 202 (-2.9A) None 017 A 202 (-4.0A)	0.39A	1fb7A-3u7sA: 19.7	1fb7A-3u7sA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3uhl	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 29 THR A 80 VAL A 82	None	0.44A	1fb7A-3uhlA: 16.1	1fb7A-3uhlA: 76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3uhl	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 THR A 80 PRO A 81 VAL A 82	None	0.56A	1fb7A-3uhlA: 16.1	1fb7A-3uhlA: 76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3upy	OXIDOREDUCTASE (Brucella abortus)	PF03447 (NAD_binding_3)	5	GLY A 121 ALA A 122 GLY A 147 PRO A 393 ILE A 425	None	1.02A	1fb7A-3upyA: undetectable	1fb7A-3upyA: 14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4b2o	YMDB PHOSPHODIESTERASE (Bacillus subtilis)	PF13277 (YmdB)	5	GLY A 59 ALA A 60 ASP A 61 VAL A 9 ILE A 36	None	0.91A	1fb7A-4b2oA: undetectable	1fb7A-4b2oA: 15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cvq	GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA (Escherichia coli)	PF00155 (Aminotran_1_2)	5	ALA A 50 ASP A 52 ILE A 296 THR A 288 ILE A 54	None	0.98A	1fb7A-4cvqA: undetectable	1fb7A-4cvqA: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4dd5	ACETYL-COA ACETYLTRANSFERASE (Clostridioides difficile)	PF00108 (Thiolase_N) PF02803 (Thiolase_C)	5	ALA A 31 GLY A 356 ILE A 355 THR A 88 ILE A 70	None	0.89A	1fb7A-4dd5A: undetectable	1fb7A-4dd5A: 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4dio	NAD(P) TRANSHYDROGENASE SUBUNIT ALPHA PART 1 (Sinorhizobium meliloti)	PF01262 (AlaDh_PNT_C) PF05222 (AlaDh_PNT_N)	5	GLY A 128 ASP A 125 THR A 393 VAL A 398 ILE A 133	None	1.00A	1fb7A-4dioA: undetectable	1fb7A-4dioA: 13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e4j	ARGININE DEIMINASE (Mycoplasma penetrans)	PF02274 (Amidinotransf)	5	GLY A 378 ALA A 379 ILE A 372 THR A 388 ILE A 384	None	0.95A	1fb7A-4e4jA: undetectable	1fb7A-4e4jA: 11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jc5	TRANSMEMBRANE PROTEIN 173 (Mus musculus)	PF15009 (TMEM173)	5	GLY A 233 GLY A 165 ILE A 164 PRO A 172 ILE A 229	None	0.92A	1fb7A-4jc5A: undetectable	1fb7A-4jc5A: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4k5u	VARIABLE LYMPHOCYTE RECEPTOR (Petromyzon marinus)	no annotation	5	GLY B 63 GLY B 18 PRO B 25 VAL B 24 ILE B 42	None	0.88A	1fb7A-4k5uB: undetectable	1fb7A-4k5uB: 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4kpo	NUCLEOSIDE N-RIBOHYDROLASE 3 (Zea mays)	PF01156 (IU_nuc_hydro)	5	GLY A 10 ASP A 12 GLY A 124 ILE A 34 ILE A 17	None CA A 401 ( 4.8A) CA A 401 ( 4.3A) None None	1.00A	1fb7A-4kpoA: undetectable	1fb7A-4kpoA: 16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ml9	UNCHARACTERIZED PROTEIN (Sebaldella termitidis)	PF00977 (His_biosynth)	5	GLY A 132 ALA A 133 ASP A 134 PRO A 109 ILE A 128	None	0.92A	1fb7A-4ml9A: undetectable	1fb7A-4ml9A: 21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	ALA A 28 ASP A 29 ASP A 30 GLY A 48 THR A 80 PRO A 81 ILE A 84	RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-4.8A) RIT A 500 (-4.8A) None RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.65A	1fb7A-4njvA: 20.5	1fb7A-4njvA: 86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 THR A 80 PRO A 81 ILE A 84	RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-4.8A) None RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.46A	1fb7A-4njvA: 20.5	1fb7A-4njvA: 86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	ASP A 25 GLY A 27 ALA A 28 ASP A 29 GLY A 49 ILE A 50 THR A 80 PRO A 81 ILE A 84	RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-3.4A) RIT A 500 (-4.3A) None RIT A 500 (-3.9A) RIT A 500 (-4.3A)	0.54A	1fb7A-4njvA: 20.5	1fb7A-4njvA: 86.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4odj	S-ADENOSYLMETHIONINE SYNTHASE (Cryptosporidium hominis)	PF00438 (S-AdoMet_synt_N) PF02772 (S-AdoMet_synt_M) PF02773 (S-AdoMet_synt_C)	5	GLY A 268 ASP A 40 GLY A 33 THR A 91 VAL A 88	None	0.97A	1fb7A-4odjA: undetectable	1fb7A-4odjA: 13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rgh	PROTEIN DDI1 HOMOLOG 2 (Homo sapiens)	PF09668 (Asp_protease)	5	ASP A 220 GLY A 222 ALA A 223 VAL A 253 PRO A 285	None	0.52A	1fb7A-4rghA: 10.6	1fb7A-4rghA: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4u1r	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINAS E, PLATELET TYPE (Homo sapiens)	PF00365 (PFK)	5	GLY A 599 ALA A 600 ASP A 601 ILE A 566 THR A 582	PO4 A 804 (-3.9A) None None None None	0.99A	1fb7A-4u1rA: undetectable	1fb7A-4u1rA: 9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xr9	CALS8 (Micromonospora echinospora)	PF00984 (UDPG_MGDP_dh) PF03720 (UDPG_MGDP_dh_C) PF03721 (UDPG_MGDP_dh_N)	5	ASP A 369 ALA A 372 THR A 349 PRO A 350 VAL A 351	None	0.78A	1fb7A-4xr9A: undetectable	1fb7A-4xr9A: 13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ydf	HTLV-1 PROTEASE (Primate T-lymphotropic virus 1)	PF00077 (RVP)	6	ASP A 32 GLY A 34 ALA A 35 ASP A 36 GLY A 58 ILE A 100	4B1 A 201 (-2.9A) 4B1 A 201 ( 4.6A) 4B1 A 201 (-3.6A) 4B1 A 201 (-4.4A) 4B1 A 201 (-3.4A) 4B1 A 201 (-4.8A)	0.44A	1fb7A-4ydfA: 13.1	1fb7A-4ydfA: 29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4z7g	SERINE/THREONINE-PRO TEIN KINASE/ENDORIBONUCLE ASE IRE1 (Homo sapiens)	PF00069 (Pkinase) PF06479 (Ribonuc_2-5A)	5	ALA A 641 VAL A 586 ILE A 601 VAL A 566 ILE A 569	None	0.95A	1fb7A-4z7gA: undetectable	1fb7A-4z7gA: 13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 30 THR A 80 PRO A 81 ILE A 84	None	0.50A	1fb7A-5b18A: 18.0	1fb7A-5b18A: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 ILE A 84	None	0.69A	1fb7A-5b18A: 18.0	1fb7A-5b18A: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	GLY A 27 ALA A 28 ASP A 29 ASP A 30 THR A 80 ILE A 84	None	0.44A	1fb7A-5b18A: 18.0	1fb7A-5b18A: 75.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gtj	DUAL SPECIFICITY PROTEIN PHOSPHATASE 26 (Homo sapiens)	PF00782 (DSPc)	5	ALA A 62 ASP A 63 VAL A 156 GLY A 155 VAL A 91	None None PO4 A 301 (-3.9A) PO4 A 301 (-3.8A) None	0.98A	1fb7A-5gtjA: undetectable	1fb7A-5gtjA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5h9u	S-ADENOSYLMETHIONINE SYNTHASE (Thermus thermophilus)	no annotation	5	GLY C 253 ASP C 22 GLY C 15 THR C 73 VAL C 70	None	0.97A	1fb7A-5h9uC: undetectable	1fb7A-5h9uC: 14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5opf	CHITIN-BINDING DOMAIN 3 PROTEIN (Micromonospora aurantiaca)	no annotation	5	GLY A 145 ALA A 146 ASP A 147 THR A 210 ILE A 149	None	0.90A	1fb7A-5opfA: undetectable	1fb7A-5opfA: 18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	ASP A 25 ALA A 28 ASP A 29 VAL A 48 GLY A 49 ILE A 50	None	1.27A	1fb7A-5t2zA: 19.7	1fb7A-5t2zA: 81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 48 GLY A 49 ILE A 50 THR A 80 ILE A 84	None	0.58A	1fb7A-5t2zA: 19.7	1fb7A-5t2zA: 81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	10	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 VAL A 48 GLY A 49 THR A 80 PRO A 81 ILE A 84	None	0.52A	1fb7A-5t2zA: 19.7	1fb7A-5t2zA: 81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ve3	BPPRF (Paraburkholderia phytofirmans)	no annotation	5	GLY B 88 ALA B 89 ASP B 90 VAL B 59 ILE B 80	None	0.90A	1fb7A-5ve3B: undetectable	1fb7A-5ve3B: 12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5vm2	ALCOHOL DEHYDROGENASE (Escherichia coli)	PF00107 (ADH_zinc_N) PF08240 (ADH_N)	5	GLY A 237 ALA A 238 ASP A 239 VAL A 199 ILE A 173	None	0.77A	1fb7A-5vm2A: undetectable	1fb7A-5vm2A: 12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xj1	UNCHARACTERIZED RNA METHYLTRANSFERASE SP_1029 (Streptococcus pneumoniae)	no annotation	5	GLY A 399 ALA A 400 ASP A 401 ILE A 373 ILE A 378	None	0.98A	1fb7A-5xj1A: undetectable	1fb7A-5xj1A: 14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5y1g	NAD DEPENDENT EPIMERASE/DEHYDRATAS E FAMILY (uncultured archaeon MedDCM-OCT-S05-C57)	no annotation	5	GLY A 192 ALA A 188 ASP A 187 THR A 296 ILE A 249	None	0.91A	1fb7A-5y1gA: undetectable	1fb7A-5y1gA: 12.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6fiv	RETROPEPSIN (Feline immunodeficiency virus)	PF00077 (RVP)	6	ASP A 30 GLY A 32 ALA A 33 ASP A 34 GLY A 58 VAL A 99	3TL A 201 (-3.5A) 3TL A 201 (-3.4A) 3TL A 201 (-4.0A) 3TL A 201 (-3.9A) 3TL A 201 (-3.4A) None	0.45A	1fb7A-6fivA: 15.7	1fb7A-6fivA: 30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 GLY A 49 THR A 80 ILE A 84	NIU A 100 (-2.8A) NIU A 100 (-4.5A) NIU A 100 (-3.6A) None None NIU A 100 ( 3.8A) None None	0.62A	1fb7A-6upjA: 17.9	1fb7A-6upjA: 46.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	8	ASP A 25 GLY A 27 ALA A 28 ASP A 29 ASP A 30 THR A 80 PRO A 81 ILE A 84	NIU A 100 (-2.8A) NIU A 100 (-4.5A) NIU A 100 (-3.6A) None None None None None	0.49A	1fb7A-6upjA: 17.9	1fb7A-6upjA: 46.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	GLY A 27 ASP A 29 ASP A 30 GLY A 49 ILE A 50 THR A 80	NIU A 100 (-4.5A) None None NIU A 100 ( 3.8A) NIU A 100 (-3.9A) None	0.79A	1fb7A-6upjA: 17.9	1fb7A-6upjA: 46.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	6	GLY A 27 ASP A 29 ASP A 30 ILE A 50 THR A 80 PRO A 81	NIU A 100 (-4.5A) None None NIU A 100 (-3.9A) None None	0.76A	1fb7A-6upjA: 17.9	1fb7A-6upjA: 46.46

[["1FB7_A_ROCA100_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"ALA A  28;ASP A  29;GLY A  48;THR A  80;PRO A  81;VAL A  82;ILE A  84","A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 (-4.1A);None;A79 A 800 ( 3.4A);A79 A 800 (-4.5A);A79 A 800 (-3.8A)","0.69A","1fb7A-1hvcA:13.8","1fb7A-1hvcA:47.78"],["1FB7_A_ROCA100_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"ALA A  28;ASP A  29;GLY A  48;THR A  80;VAL A  82;ILE A  84","A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 (-3.6A);None;A79 A 800 (-4.5A);A79 A 800 (-3.6A)","0.67A","1fb7A-1hvcA:13.8","1fb7A-1hvcA:47.78"],["1FB7_A_ROCA100_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",11,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;THR A  80;PRO A  81;VAL A  82;ILE A  84","A79 A 800 (-2.7A);A79 A 800 (-3.0A);A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 ( 4.9A);A79 A 800 ( 3.7A);A79 A 800 (-3.8A);None;A79 A 800 ( 3.9A);A79 A 800 (-4.5A);A79 A 800 (-3.6A)","0.40A","1fb7A-1hvcA:13.8","1fb7A-1hvcA:47.78"],["1FB7_A_ROCA100_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",10,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;THR A  80;VAL A  82;ILE A  84","A79 A 800 (-2.8A);A79 A 800 (-3.0A);A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 ( 4.7A);A79 A 800 (-3.4A);A79 A 800 ( 4.0A);None;A79 A 800 (-4.5A);A79 A 800 (-3.8A)","0.44A","1fb7A-1hvcA:13.8","1fb7A-1hvcA:47.78"],["1FB7_A_ROCA100_1","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",10,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;THR A  80;PRO A  81;VAL A  82;ILE A  84","A79 A 800 (-2.8A);A79 A 800 (-3.0A);A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 ( 4.7A);A79 A 800 (-3.4A);None;A79 A 800 ( 3.4A);A79 A 800 (-4.5A);A79 A 800 (-3.8A)","0.40A","1fb7A-1hvcA:13.8","1fb7A-1hvcA:47.78"],["1FB7_A_ROCA100_1","1imv","Homo sapiens","PIGMENT EPITHELIUM-DERIVED FACTOR","PF00079(Serpin)",5,"ASP A 156;VAL A 148;ILE A 122;VAL A 164;ILE A 160","None","0.90A","1fb7A-1imvA:undetectable","1fb7A-1imvA:12.37"],["1FB7_A_ROCA100_1","1m0s","Haemophilus influenzae","RIBOSE-5-PHOSPHATE ISOMERASE A","PF06026(Rib_5-P_isom_A)",5,"GLY A  97;ALA A  98;GLY A 197;ILE A  93;ILE A 169","CIT A 501 (-3.1A);None;None;None;None","1.01A","1fb7A-1m0sA:undetectable","1fb7A-1m0sA:18.39"],["1FB7_A_ROCA100_1","1o5w","Rattus norvegicus","AMINE OXIDASE [FLAVIN-CONTAINING] A","PF01593(Amino_oxidase)",5,"ASP A  64;GLY A 222;VAL A  48;GLY A  49;ILE A  23","None;None;None;None;FAD A 652 (-4.8A)","0.87A","1fb7A-1o5wA:undetectable","1fb7A-1o5wA:10.88"],["1FB7_A_ROCA100_1","1p2f","Thermotoga maritima","RESPONSE REGULATOR","PF00072(Response_reg);PF00486(Trans_reg_C)",5,"GLY A  93;ALA A  94;ASP A  95;ILE A  61;THR A  78","None","0.85A","1fb7A-1p2fA:undetectable","1fb7A-1p2fA:18.02"],["1FB7_A_ROCA100_1","1q9p","Homo sapiens","HIV-1 PROTEASE","PF00077(RVP)",7,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;THR A  80;ILE A  84","None","0.49A","1fb7A-1q9pA:10.5","1fb7A-1q9pA:91.58"],["1FB7_A_ROCA100_1","1q9p","Homo sapiens","HIV-1 PROTEASE","PF00077(RVP)",7,"ASP A  25;GLY A  27;ALA A  28;ASP A  30;THR A  80;PRO A  81;ILE A  84","None","0.68A","1fb7A-1q9pA:10.5","1fb7A-1q9pA:91.58"],["1FB7_A_ROCA100_1","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",5,"ALA A  28;GLY A  48;THR A  80;PRO A  81;ILE A  84","None","0.57A","1fb7A-1sivA:18.1","1fb7A-1sivA:48.48"],["1FB7_A_ROCA100_1","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",5,"ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None","1.00A","1fb7A-1sivA:18.1","1fb7A-1sivA:48.48"],["1FB7_A_ROCA100_1","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",10,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;THR A  80;PRO A  81;ILE A  84","None","0.48A","1fb7A-1sivA:18.1","1fb7A-1sivA:48.48"],["1FB7_A_ROCA100_1","1tjr","Zea mays","BX1","PF00290(Trp_syntA)",5,"GLY A 307;ALA A 308;ASP A 309;VAL A 269;ILE A 303","None","0.81A","1fb7A-1tjrA:undetectable","1fb7A-1tjrA:18.92"],["1FB7_A_ROCA100_1","1uxi","Chloroflexus aurantiacus","MALATE DEHYDROGENASE","PF00056(Ldh_1_N);PF02866(Ldh_1_C)",5,"ALA A 169;VAL A 146;GLY A 145;THR A 209;VAL A 206","None","1.02A","1fb7A-1uxiA:undetectable","1fb7A-1uxiA:15.59"],["1FB7_A_ROCA100_1","1vrg","Thermotoga maritima","PROPIONYL-COA CARBOXYLASE, BETA SUBUNIT","PF01039(Carboxyl_trans)",5,"GLY A 416;ALA A 417;ASP A 418;ILE A 346;VAL A 360","None","0.84A","1fb7A-1vrgA:undetectable","1fb7A-1vrgA:11.62"],["1FB7_A_ROCA100_1","1w3f","Laetiporus sulphureus","HEMOLYTIC LECTIN FROM LAETIPORUS SULPHUREUS","PF03318(ETX_MTX2)",5,"GLY A 241;GLY A 296;ILE A 297;PRO A 221;VAL A 220","None","0.91A","1fb7A-1w3fA:undetectable","1fb7A-1w3fA:16.67"],["1FB7_A_ROCA100_1","1wl4","Homo sapiens","ACETYL-COENZYME A ACETYLTRANSFERASE 2","PF00108(Thiolase_N);PF02803(Thiolase_C)",5,"ALA A 381;VAL A 394;GLY A 378;ILE A 317;ILE A 301","None","0.85A","1fb7A-1wl4A:undetectable","1fb7A-1wl4A:13.07"],["1FB7_A_ROCA100_1","1x0u","Sulfurisphaera tokodaii","HYPOTHETICAL METHYLMALONYL-COA DECARBOXYLASE ALPHA SUBUNIT","PF01039(Carboxyl_trans)",5,"GLY A 424;ALA A 425;ASP A 426;ILE A 354;VAL A 368","None","0.84A","1fb7A-1x0uA:undetectable","1fb7A-1x0uA:11.65"],["1FB7_A_ROCA100_1","2fmb","Equine infectious anemia virus","EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;GLY A  55;PRO A  86;VAL A  87;ILE A  89","LP1 A 201 (-2.3A);LP1 A 201 (-3.8A);LP1 A 201 (-3.5A);LP1 A 201 (-3.6A);LP1 A 201 (-3.4A);LP1 A 201 (-3.9A);LP1 A 201 ( 4.9A);LP1 A 201 (-4.2A)","0.38A","1fb7A-2fmbA:15.2","1fb7A-2fmbA:29.81"],["1FB7_A_ROCA100_1","2ics","Enterococcus faecalis","ADENINE DEAMINASE","PF01979(Amidohydro_1)",5,"ASP A 330;VAL A  79;GLY A  78;ILE A  77;ILE A  57","None","0.92A","1fb7A-2icsA:undetectable","1fb7A-2icsA:14.78"],["1FB7_A_ROCA100_1","2isq","Arabidopsis thaliana","CYSTEINE SYNTHASE","PF00291(PALP)",5,"GLY A 190;ALA A 189;GLY A 183;ILE A 180;PRO A 296","None;None;PLP A 400 (-3.4A);PLP A 400 (-4.9A);PLP A 400 (-4.0A)","0.81A","1fb7A-2isqA:undetectable","1fb7A-2isqA:15.00"],["1FB7_A_ROCA100_1","2obv","Homo sapiens","S-ADENOSYLMETHIONINE SYNTHETASE ISOFORM TYPE-1","PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",5,"GLY A 260;ASP A  35;GLY A  28;THR A  86;VAL A  83","None","0.94A","1fb7A-2obvA:undetectable","1fb7A-2obvA:15.36"],["1FB7_A_ROCA100_1","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",6,"ALA A  28;ASP A  29;GLY A  48;THR A  80;PRO A  81;ILE A  84","AB1 A 501 (-3.5A);AB1 A 501 ( 3.3A);AB1 A 501 (-4.2A);None;AB1 A 501 (-4.2A);AB1 A 501 ( 4.2A)","0.69A","1fb7A-2rkfA:20.5","1fb7A-2rkfA:84.85"],["1FB7_A_ROCA100_1","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;THR A  80;ILE A  84","AB1 A 501 (-2.4A);AB1 A 501 (-3.9A);AB1 A 501 (-3.5A);AB1 A 501 ( 3.3A);AB1 A 501 (-3.8A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A);None;AB1 A 501 ( 4.2A)","0.32A","1fb7A-2rkfA:20.5","1fb7A-2rkfA:84.85"],["1FB7_A_ROCA100_1","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;ILE A  50;THR A  80;PRO A  81;ILE A  84","AB1 A 501 (-2.4A);AB1 A 501 (-3.9A);AB1 A 501 (-3.5A);AB1 A 501 ( 3.3A);AB1 A 501 (-3.8A);AB1 A 501 (-3.8A);None;AB1 A 501 (-4.2A);AB1 A 501 ( 4.2A)","0.46A","1fb7A-2rkfA:20.5","1fb7A-2rkfA:84.85"],["1FB7_A_ROCA100_1","2rsp","Rous sarcoma virus","RSV PROTEASE","PF00077(RVP)",5,"ASP A  37;GLY A  39;ALA A  40;ASP A  41;ILE A 108","None","0.32A","1fb7A-2rspA:12.6","1fb7A-2rspA:32.00"],["1FB7_A_ROCA100_1","2v6c","Mus musculus","PROLIFERATION-ASSOCIATED PROTEIN 2G4","PF00557(Peptidase_M24)",5,"ASP A  53;GLY A  52;VAL A 121;PRO A 277;ILE A  74","None","1.00A","1fb7A-2v6cA:undetectable","1fb7A-2v6cA:13.03"],["1FB7_A_ROCA100_1","2vn8","Homo sapiens","RETICULON-4-INTERACTING PROTEIN 1","PF08240(ADH_N);PF13602(ADH_zinc_N_2)",5,"GLY A 248;ALA A 249;ASP A 250;ASP A 251;VAL A 208","None","0.80A","1fb7A-2vn8A:undetectable","1fb7A-2vn8A:14.53"],["1FB7_A_ROCA100_1","2yb4","Chromobacterium violaceum","AMIDOHYDROLASE","PF02811(PHP)",5,"GLY A 182;ALA A 183;THR A  42;VAL A  63;ILE A  81","None","1.02A","1fb7A-2yb4A:undetectable","1fb7A-2yb4A:18.55"],["1FB7_A_ROCA100_1","2z5x","Homo sapiens","AMINE OXIDASE [FLAVIN-CONTAINING] A","PF01593(Amino_oxidase)",5,"ASP A  64;GLY A 222;VAL A  48;GLY A  49;ILE A  23","GOL A 702 (-3.6A);GOL A 702 (-3.6A);None;FAD A 600 (-4.9A);FAD A 600 (-4.9A)","0.88A","1fb7A-2z5xA:undetectable","1fb7A-2z5xA:12.67"],["1FB7_A_ROCA100_1","2zxo","Thermus thermophilus","SINGLE-STRANDED DNA SPECIFIC EXONUCLEASE RECJ","PF01368(DHH);PF02272(DHHA1)",5,"GLY A 187;ALA A 188;VAL A 233;PRO A 207;ILE A  91","None","0.97A","1fb7A-2zxoA:undetectable","1fb7A-2zxoA:9.29"],["1FB7_A_ROCA100_1","3any","Escherichia coli","ETHANOLAMINE AMMONIA-LYASE HEAVY CHAIN","PF06751(EutB)",5,"ASP A 214;ASP A 207;GLY A 241;THR A 220;ILE A 213","None","1.00A","1fb7A-3anyA:undetectable","1fb7A-3anyA:12.56"],["1FB7_A_ROCA100_1","3c3k","Actinobacillus succinogenes","ALANINE RACEMASE","PF13377(Peripla_BP_3)",5,"GLY A 198;ALA A 197;VAL A 217;GLY A 218;ILE A 224","None","0.98A","1fb7A-3c3kA:undetectable","1fb7A-3c3kA:15.87"],["1FB7_A_ROCA100_1","3gve","Bacillus subtilis","YFKN PROTEIN","PF00149(Metallophos)",5,"GLY A 121;ALA A 122;ASP A 123;ILE A  89;ILE A 126","None","0.74A","1fb7A-3gveA:undetectable","1fb7A-3gveA:15.11"],["1FB7_A_ROCA100_1","3h1l","Gallus gallus","MITOCHONDRIAL UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN 2","PF00675(Peptidase_M16);PF05193(Peptidase_M16_C)",5,"ALA B  36;VAL B  49;GLY B  48;ILE B  47;ILE B 382","None","0.93A","1fb7A-3h1lB:undetectable","1fb7A-3h1lB:14.73"],["1FB7_A_ROCA100_1","3hdf","Escherichia virus Lambda","LYSOZYME","PF00959(Phage_lysozyme)",5,"ALA A 131;ASP A 127;GLY A 163;PRO A  95;ILE A 123","None","1.00A","1fb7A-3hdfA:undetectable","1fb7A-3hdfA:19.57"],["1FB7_A_ROCA100_1","3i5g","Doryteuthis pealeii","MYOSIN HEAVY CHAIN ISOFORM A","PF00063(Myosin_head);PF00612(IQ);PF02736(Myosin_N)",5,"ALA A 265;ASP A 266;GLY A 460;ILE A 459;ILE A 224","None","0.96A","1fb7A-3i5gA:undetectable","1fb7A-3i5gA:8.61"],["1FB7_A_ROCA100_1","3i5g","Doryteuthis pealeii","MYOSIN HEAVY CHAIN ISOFORM A","PF00063(Myosin_head);PF00612(IQ);PF02736(Myosin_N)",5,"GLY A 264;ALA A 265;ASP A 266;GLY A 460;ILE A 459","None","0.83A","1fb7A-3i5gA:undetectable","1fb7A-3i5gA:8.61"],["1FB7_A_ROCA100_1","3j2i","Homo sapiens","PROLIFERATION-ASSOCIATED PROTEIN 2G4","PF00557(Peptidase_M24)",5,"ASP A  53;GLY A  52;VAL A 121;PRO A 277;ILE A  74","None","1.01A","1fb7A-3j2iA:undetectable","1fb7A-3j2iA:13.55"],["1FB7_A_ROCA100_1","3kvo","Homo sapiens","HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2","PF00106(adh_short)",5,"GLY A 128;ASP A  74;GLY A  17;VAL A  85;ILE A  81","None;NAP A 501 (-3.5A);NAP A 501 (-3.3A);None;None","0.95A","1fb7A-3kvoA:undetectable","1fb7A-3kvoA:15.52"],["1FB7_A_ROCA100_1","3mwc","Kosmotoga olearia","MANDELATE RACEMASE\/MUCONATE LACTONIZING PROTEIN","PF02746(MR_MLE_N);PF13378(MR_MLE_C)",5,"GLY A 310;ALA A 336;ASP A 337;VAL A 363;ILE A 149","None","1.01A","1fb7A-3mwcA:undetectable","1fb7A-3mwcA:12.75"],["1FB7_A_ROCA100_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"ALA A  28;ASP A  30;GLY A  48;THR A  80;PRO A  81;VAL A  82","None","0.76A","1fb7A-3mwsA:19.3","1fb7A-3mwsA:75.76"],["1FB7_A_ROCA100_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;THR A  80;PRO A  81;VAL A  82;ILE A  84","None","0.61A","1fb7A-3mwsA:19.3","1fb7A-3mwsA:75.76"],["1FB7_A_ROCA100_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;GLY A  49;ILE A  50;THR A  80;VAL A  82;ILE A  84","None","0.54A","1fb7A-3mwsA:19.3","1fb7A-3mwsA:75.76"],["1FB7_A_ROCA100_1","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;GLY A  49;THR A  80;PRO A  81;VAL A  82;ILE A  84","None","0.59A","1fb7A-3mwsA:19.3","1fb7A-3mwsA:75.76"],["1FB7_A_ROCA100_1","3nep","Salinibacter ruber","MALATE DEHYDROGENASE","PF00056(Ldh_1_N);PF02866(Ldh_1_C)",5,"ALA X 189;VAL X 166;GLY X 165;THR X 231;VAL X 228","None","0.94A","1fb7A-3nepX:undetectable","1fb7A-3nepX:15.18"],["1FB7_A_ROCA100_1","3nns","Thermotoga maritima","DNA BINDING RESPONSE REGULATOR B","PF00072(Response_reg)",5,"GLY A  93;ALA A  94;ASP A  95;ILE A  61;THR A  78","None;None;None;None;BEF A 402 (-3.6A)","0.82A","1fb7A-3nnsA:undetectable","1fb7A-3nnsA:20.66"],["1FB7_A_ROCA100_1","3o8o","Saccharomyces cerevisiae","6-PHOSPHOFRUCTOKINASE SUBUNIT ALPHA","PF00365(PFK)",5,"GLY A 414;ALA A 415;ASP A 416;VAL A 397;ILE A 452","None","0.93A","1fb7A-3o8oA:undetectable","1fb7A-3o8oA:8.31"],["1FB7_A_ROCA100_1","3opy","Komagataella pastoris","6-PHOSPHOFRUCTO-1-KINASE ALPHA-SUBUNIT","PF00365(PFK)",5,"GLY A 419;ALA A 420;ASP A 421;VAL A 402;ILE A 457","None","0.83A","1fb7A-3opyA:undetectable","1fb7A-3opyA:8.54"],["1FB7_A_ROCA100_1","3r8y","Bacillus anthracis","2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATE N-ACETYLTRANSFERASE","PF00132(Hexapep);PF08503(DapH_N);PF14602(Hexapep_2)",5,"ALA A  92;ASP A 108;GLY A  89;VAL A 104;ILE A 106","None","1.01A","1fb7A-3r8yA:undetectable","1fb7A-3r8yA:18.41"],["1FB7_A_ROCA100_1","3slz","Murine leukemia virus","GAG-PRO-POL POLYPROTEIN","PF00077(RVP)",5,"ASP A  32;GLY A  34;ALA A  35;GLY A  56;PRO A  89","3TL A 126 (-2.4A);3TL A 126 (-3.1A);3TL A 126 ( 4.0A);3TL A 126 (-3.4A);3TL A 126 (-4.0A)","0.66A","1fb7A-3slzA:11.3","1fb7A-3slzA:26.67"],["1FB7_A_ROCA100_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  29;ASP A  30;THR A  80;PRO A  81","017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.2A);None;None","0.42A","1fb7A-3t3cA:18.0","1fb7A-3t3cA:77.78"],["1FB7_A_ROCA100_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50","017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.2A);017 A 201 (-4.0A);017 A 201 (-3.3A)","0.31A","1fb7A-3t3cA:18.0","1fb7A-3t3cA:77.78"],["1FB7_A_ROCA100_1","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;THR A  80","017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.2A);None","0.39A","1fb7A-3t3cA:18.0","1fb7A-3t3cA:77.78"],["1FB7_A_ROCA100_1","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50;THR A  80;ILE A  84","017 A 201 (-2.6A);017 A 201 (-3.6A);017 A 201 (-3.4A);017 A 201 (-3.3A);017 A 201 (-4.6A);017 A 201 (-3.0A);017 A 201 (-3.3A);None;017 A 201 (-4.7A)","0.59A","1fb7A-3ttpA:19.1","1fb7A-3ttpA:76.77"],["1FB7_A_ROCA100_1","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;THR A  80;PRO A  81;ILE A  84","017 A 201 (-2.6A);017 A 201 (-3.6A);017 A 201 (-3.4A);017 A 201 (-3.3A);017 A 201 (-4.6A);017 A 201 (-3.0A);None;017 A 201 (-4.1A);017 A 201 (-4.7A)","0.54A","1fb7A-3ttpA:19.1","1fb7A-3ttpA:76.77"],["1FB7_A_ROCA100_1","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",5,"ASP A  29;ASP A  30;GLY A  48;THR A  80;PRO A  81","017 A 201 (-3.3A);017 A 201 (-4.6A);None;None;017 A 201 (-4.1A)","0.74A","1fb7A-3ttpA:19.1","1fb7A-3ttpA:76.77"],["1FB7_A_ROCA100_1","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",7,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  50","017 A 202 ( 2.5A);017 A 201 ( 3.5A);017 A 201 (-3.4A);017 A 201 (-3.2A);017 A 201 ( 4.0A);017 A 202 (-2.9A);017 A 201 ( 3.5A)","0.34A","1fb7A-3u7sA:19.7","1fb7A-3u7sA:78.79"],["1FB7_A_ROCA100_1","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;THR A  80;PRO A  81","017 A 202 ( 2.5A);017 A 201 ( 3.5A);017 A 201 (-3.4A);017 A 201 (-3.2A);017 A 201 ( 4.0A);017 A 202 (-2.9A);None;017 A 202 (-4.0A)","0.39A","1fb7A-3u7sA:19.7","1fb7A-3u7sA:78.79"],["1FB7_A_ROCA100_1","3uhl","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;THR A  80;VAL A  82","None","0.44A","1fb7A-3uhlA:16.1","1fb7A-3uhlA:76.77"],["1FB7_A_ROCA100_1","3uhl","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;THR A  80;PRO A  81;VAL A  82","None","0.56A","1fb7A-3uhlA:16.1","1fb7A-3uhlA:76.77"],["1FB7_A_ROCA100_1","3upy","Brucella abortus","OXIDOREDUCTASE","PF03447(NAD_binding_3)",5,"GLY A 121;ALA A 122;GLY A 147;PRO A 393;ILE A 425","None","1.02A","1fb7A-3upyA:undetectable","1fb7A-3upyA:14.00"],["1FB7_A_ROCA100_1","4b2o","Bacillus subtilis","YMDB PHOSPHODIESTERASE","PF13277(YmdB)",5,"GLY A  59;ALA A  60;ASP A  61;VAL A   9;ILE A  36","None","0.91A","1fb7A-4b2oA:undetectable","1fb7A-4b2oA:15.47"],["1FB7_A_ROCA100_1","4cvq","Escherichia coli","GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA","PF00155(Aminotran_1_2)",5,"ALA A  50;ASP A  52;ILE A 296;THR A 288;ILE A  54","None","0.98A","1fb7A-4cvqA:undetectable","1fb7A-4cvqA:16.52"],["1FB7_A_ROCA100_1","4dd5","Clostridioides difficile","ACETYL-COA ACETYLTRANSFERASE","PF00108(Thiolase_N);PF02803(Thiolase_C)",5,"ALA A  31;GLY A 356;ILE A 355;THR A  88;ILE A  70","None","0.89A","1fb7A-4dd5A:undetectable","1fb7A-4dd5A:13.96"],["1FB7_A_ROCA100_1","4dio","Sinorhizobium meliloti","NAD(P) TRANSHYDROGENASE SUBUNIT ALPHA PART 1","PF01262(AlaDh_PNT_C);PF05222(AlaDh_PNT_N)",5,"GLY A 128;ASP A 125;THR A 393;VAL A 398;ILE A 133","None","1.00A","1fb7A-4dioA:undetectable","1fb7A-4dioA:13.85"],["1FB7_A_ROCA100_1","4e4j","Mycoplasma penetrans","ARGININE DEIMINASE","PF02274(Amidinotransf)",5,"GLY A 378;ALA A 379;ILE A 372;THR A 388;ILE A 384","None","0.95A","1fb7A-4e4jA:undetectable","1fb7A-4e4jA:11.52"],["1FB7_A_ROCA100_1","4jc5","Mus musculus","TRANSMEMBRANE PROTEIN 173","PF15009(TMEM173)",5,"GLY A 233;GLY A 165;ILE A 164;PRO A 172;ILE A 229","None","0.92A","1fb7A-4jc5A:undetectable","1fb7A-4jc5A:17.77"],["1FB7_A_ROCA100_1","4k5u","Petromyzon marinus","VARIABLE LYMPHOCYTE RECEPTOR","no annotation",5,"GLY B  63;GLY B  18;PRO B  25;VAL B  24;ILE B  42","None","0.88A","1fb7A-4k5uB:undetectable","1fb7A-4k5uB:16.06"],["1FB7_A_ROCA100_1","4kpo","Zea mays","NUCLEOSIDE N-RIBOHYDROLASE 3","PF01156(IU_nuc_hydro)",5,"GLY A  10;ASP A  12;GLY A 124;ILE A  34;ILE A  17","None; CA A 401 ( 4.8A); CA A 401 ( 4.3A);None;None","1.00A","1fb7A-4kpoA:undetectable","1fb7A-4kpoA:16.15"],["1FB7_A_ROCA100_1","4ml9","Sebaldella termitidis","UNCHARACTERIZED PROTEIN","PF00977(His_biosynth)",5,"GLY A 132;ALA A 133;ASP A 134;PRO A 109;ILE A 128","None","0.92A","1fb7A-4ml9A:undetectable","1fb7A-4ml9A:21.52"],["1FB7_A_ROCA100_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",7,"ALA A  28;ASP A  29;ASP A  30;GLY A  48;THR A  80;PRO A  81;ILE A  84","RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-4.8A);RIT A 500 (-4.8A);None;RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.65A","1fb7A-4njvA:20.5","1fb7A-4njvA:86.87"],["1FB7_A_ROCA100_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;THR A  80;PRO A  81;ILE A  84","RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-4.8A);None;RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.46A","1fb7A-4njvA:20.5","1fb7A-4njvA:86.87"],["1FB7_A_ROCA100_1","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",9,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;GLY A  49;ILE A  50;THR A  80;PRO A  81;ILE A  84","RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-3.4A);RIT A 500 (-4.3A);None;RIT A 500 (-3.9A);RIT A 500 (-4.3A)","0.54A","1fb7A-4njvA:20.5","1fb7A-4njvA:86.87"],["1FB7_A_ROCA100_1","4odj","Cryptosporidium hominis","S-ADENOSYLMETHIONINE SYNTHASE","PF00438(S-AdoMet_synt_N);PF02772(S-AdoMet_synt_M);PF02773(S-AdoMet_synt_C)",5,"GLY A 268;ASP A  40;GLY A  33;THR A  91;VAL A  88","None","0.97A","1fb7A-4odjA:undetectable","1fb7A-4odjA:13.88"],["1FB7_A_ROCA100_1","4rgh","Homo sapiens","PROTEIN DDI1 HOMOLOG 2","PF09668(Asp_protease)",5,"ASP A 220;GLY A 222;ALA A 223;VAL A 253;PRO A 285","None","0.52A","1fb7A-4rghA:10.6","1fb7A-4rghA:18.34"],["1FB7_A_ROCA100_1","4u1r","Homo sapiens","ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE","PF00365(PFK)",5,"GLY A 599;ALA A 600;ASP A 601;ILE A 566;THR A 582","PO4 A 804 (-3.9A);None;None;None;None","0.99A","1fb7A-4u1rA:undetectable","1fb7A-4u1rA:9.59"],["1FB7_A_ROCA100_1","4xr9","Micromonospora echinospora","CALS8","PF00984(UDPG_MGDP_dh);PF03720(UDPG_MGDP_dh_C);PF03721(UDPG_MGDP_dh_N)",5,"ASP A 369;ALA A 372;THR A 349;PRO A 350;VAL A 351","None","0.78A","1fb7A-4xr9A:undetectable","1fb7A-4xr9A:13.59"],["1FB7_A_ROCA100_1","4ydf","Primate T-lymphotropic virus 1","HTLV-1 PROTEASE","PF00077(RVP)",6,"ASP A  32;GLY A  34;ALA A  35;ASP A  36;GLY A  58;ILE A 100","4B1 A 201 (-2.9A);4B1 A 201 ( 4.6A);4B1 A 201 (-3.6A);4B1 A 201 (-4.4A);4B1 A 201 (-3.4A);4B1 A 201 (-4.8A)","0.44A","1fb7A-4ydfA:13.1","1fb7A-4ydfA:29.57"],["1FB7_A_ROCA100_1","4z7g","Homo sapiens","SERINE\/THREONINE-PROTEIN KINASE\/ENDORIBONUCLEASE IRE1","PF00069(Pkinase);PF06479(Ribonuc_2-5A)",5,"ALA A 641;VAL A 586;ILE A 601;VAL A 566;ILE A 569","None","0.95A","1fb7A-4z7gA:undetectable","1fb7A-4z7gA:13.98"],["1FB7_A_ROCA100_1","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  30;THR A  80;PRO A  81;ILE A  84","None","0.50A","1fb7A-5b18A:18.0","1fb7A-5b18A:75.76"],["1FB7_A_ROCA100_1","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;ILE A  84","None","0.69A","1fb7A-5b18A:18.0","1fb7A-5b18A:75.76"],["1FB7_A_ROCA100_1","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"GLY A  27;ALA A  28;ASP A  29;ASP A  30;THR A  80;ILE A  84","None","0.44A","1fb7A-5b18A:18.0","1fb7A-5b18A:75.76"],["1FB7_A_ROCA100_1","5gtj","Homo sapiens","DUAL SPECIFICITY PROTEIN PHOSPHATASE 26","PF00782(DSPc)",5,"ALA A  62;ASP A  63;VAL A 156;GLY A 155;VAL A  91","None;None;PO4 A 301 (-3.9A);PO4 A 301 (-3.8A);None","0.98A","1fb7A-5gtjA:undetectable","1fb7A-5gtjA:21.71"],["1FB7_A_ROCA100_1","5h9u","Thermus thermophilus","S-ADENOSYLMETHIONINE SYNTHASE","no annotation",5,"GLY C 253;ASP C  22;GLY C  15;THR C  73;VAL C  70","None","0.97A","1fb7A-5h9uC:undetectable","1fb7A-5h9uC:14.14"],["1FB7_A_ROCA100_1","5opf","Micromonospora aurantiaca","CHITIN-BINDING DOMAIN 3 PROTEIN","no annotation",5,"GLY A 145;ALA A 146;ASP A 147;THR A 210;ILE A 149","None","0.90A","1fb7A-5opfA:undetectable","1fb7A-5opfA:18.37"],["1FB7_A_ROCA100_1","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"ASP A  25;ALA A  28;ASP A  29;VAL A  48;GLY A  49;ILE A  50","None","1.27A","1fb7A-5t2zA:19.7","1fb7A-5t2zA:81.82"],["1FB7_A_ROCA100_1","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",10,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  48;GLY A  49;ILE A  50;THR A  80;ILE A  84","None","0.58A","1fb7A-5t2zA:19.7","1fb7A-5t2zA:81.82"],["1FB7_A_ROCA100_1","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",10,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;VAL A  48;GLY A  49;THR A  80;PRO A  81;ILE A  84","None","0.52A","1fb7A-5t2zA:19.7","1fb7A-5t2zA:81.82"],["1FB7_A_ROCA100_1","5ve3","Paraburkholderia phytofirmans","BPPRF","no annotation",5,"GLY B  88;ALA B  89;ASP B  90;VAL B  59;ILE B  80","None","0.90A","1fb7A-5ve3B:undetectable","1fb7A-5ve3B:12.85"],["1FB7_A_ROCA100_1","5vm2","Escherichia coli","ALCOHOL DEHYDROGENASE","PF00107(ADH_zinc_N);PF08240(ADH_N)",5,"GLY A 237;ALA A 238;ASP A 239;VAL A 199;ILE A 173","None","0.77A","1fb7A-5vm2A:undetectable","1fb7A-5vm2A:12.43"],["1FB7_A_ROCA100_1","5xj1","Streptococcus pneumoniae","UNCHARACTERIZED RNA METHYLTRANSFERASE SP_1029","no annotation",5,"GLY A 399;ALA A 400;ASP A 401;ILE A 373;ILE A 378","None","0.98A","1fb7A-5xj1A:undetectable","1fb7A-5xj1A:14.03"],["1FB7_A_ROCA100_1","5y1g","uncultured archaeon MedDCM-OCT-S05-C57","NAD DEPENDENT EPIMERASE\/DEHYDRATASE FAMILY","no annotation",5,"GLY A 192;ALA A 188;ASP A 187;THR A 296;ILE A 249","None","0.91A","1fb7A-5y1gA:undetectable","1fb7A-5y1gA:12.73"],["1FB7_A_ROCA100_1","6fiv","Feline immunodeficiency virus","RETROPEPSIN","PF00077(RVP)",6,"ASP A  30;GLY A  32;ALA A  33;ASP A  34;GLY A  58;VAL A  99","3TL A 201 (-3.5A);3TL A 201 (-3.4A);3TL A 201 (-4.0A);3TL A 201 (-3.9A);3TL A 201 (-3.4A);None","0.45A","1fb7A-6fivA:15.7","1fb7A-6fivA:30.43"],["1FB7_A_ROCA100_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;GLY A  49;THR A  80;ILE A  84","NIU A 100 (-2.8A);NIU A 100 (-4.5A);NIU A 100 (-3.6A);None;None;NIU A 100 ( 3.8A);None;None","0.62A","1fb7A-6upjA:17.9","1fb7A-6upjA:46.46"],["1FB7_A_ROCA100_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",8,"ASP A  25;GLY A  27;ALA A  28;ASP A  29;ASP A  30;THR A  80;PRO A  81;ILE A  84","NIU A 100 (-2.8A);NIU A 100 (-4.5A);NIU A 100 (-3.6A);None;None;None;None;None","0.49A","1fb7A-6upjA:17.9","1fb7A-6upjA:46.46"],["1FB7_A_ROCA100_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"GLY A  27;ASP A  29;ASP A  30;GLY A  49;ILE A  50;THR A  80","NIU A 100 (-4.5A);None;None;NIU A 100 ( 3.8A);NIU A 100 (-3.9A);None","0.79A","1fb7A-6upjA:17.9","1fb7A-6upjA:46.46"],["1FB7_A_ROCA100_1","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",6,"GLY A  27;ASP A  29;ASP A  30;ILE A  50;THR A  80;PRO A  81","NIU A 100 (-4.5A);None;None;NIU A 100 (-3.9A);None;None","0.76A","1fb7A-6upjA:17.9","1fb7A-6upjA:46.46"]]