SIMILAR PATTERNS OF AMINO ACIDS FOR 1F86_B_T44B528

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci9 PROTEIN
(CARBOXYLESTERASE)

(Burkholderia
gladioli) 		PF00144
(Beta-lactamase) 		4 LYS A  78
LEU A 185
ALA A  82
LEU A 188
 DFP  A 401 ( 4.2A)
None
None
None
 1.37A 1f86B-1ci9A:
0.0		 1f86B-1ci9A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LYS A 496
LEU A 492
ALA A 495
LEU A 322
 None
 1.45A 1f86B-1gz4A:
0.0		 1f86B-1gz4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		4 LYS A  55
LEU A  59
ALA A 264
LEU A 258
 None
 1.22A 1f86B-1p99A:
0.0		 1f86B-1p99A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.20A 1f86B-1r1nA:
0.0		 1f86B-1r1nA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LYS A 431
LEU A 427
ALA A 312
LEU A 308
 None
 1.44A 1f86B-1rzvA:
undetectable		 1f86B-1rzvA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 LYS A 398
LEU A 394
ALA A 406
LEU A 340
 None
 1.36A 1f86B-1sc6A:
0.0		 1f86B-1sc6A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 LYS B 496
LEU B 464
ALA B 493
LEU B 435
 None
 1.40A 1f86B-1skyB:
0.0		 1f86B-1skyB:
10.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.60A 1f86B-1sn2A:
21.1		 1f86B-1sn2A:
56.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.49A 1f86B-1tfpA:
19.0		 1f86B-1tfpA:
77.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.15A 1f86B-1xmbA:
undetectable		 1f86B-1xmbA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LYS A 166
LEU A 162
ALA A 309
LEU A 305
 None
 1.10A 1f86B-1xvxA:
undetectable		 1f86B-1xvxA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.18A 1f86B-1xvyA:
undetectable		 1f86B-1xvyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		4 LYS A 186
LEU A 188
ALA A 202
LEU A 200
 None
 1.06A 1f86B-1yk3A:
undetectable		 1f86B-1yk3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1v STE50 PROTEIN

(Saccharomyces
cerevisiae) 		PF09235
(Ste50p-SAM) 		4 LYS A  88
LEU A  56
ALA A  89
LEU A  81
 None
 1.44A 1f86B-1z1vA:
undetectable		 1f86B-1z1vA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 LYS A 280
LEU A 276
ALA A 343
LEU A 339
 None
 1.35A 1f86B-1zgjA:
undetectable		 1f86B-1zgjA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b87 ANTI-ZTAQ AFFIBODY

(Staphylococcus
aureus) 		PF02216
(B) 		4 LYS B  49
LEU B  45
ALA B  48
LEU B  44
 None
 1.37A 1f86B-2b87B:
undetectable		 1f86B-2b87B:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckx TELOMERE BINDING
PROTEIN TBP1

(Nicotiana
tabacum) 		PF00249
(Myb_DNA-binding) 		4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.19A 1f86B-2ckxA:
undetectable		 1f86B-2ckxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 LYS A 295
LEU A 297
ALA A 290
LEU A 194
 None
 1.48A 1f86B-2d0jA:
undetectable		 1f86B-2d0jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		4 LYS A  86
LEU A  90
ALA A  65
LEU A  61
 None
 1.07A 1f86B-2e1dA:
undetectable		 1f86B-2e1dA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i02 GENERAL STRESS
PROTEIN OF COG3871

(Nostoc
punctiforme) 		PF16242
(Pyrid_ox_like) 		4 LYS A  95
LEU A  93
ALA A 122
LEU A 124
 P33  A 201 (-3.3A)
None
P33  A 201 ( 3.9A)
None
 1.03A 1f86B-2i02A:
undetectable		 1f86B-2i02A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR

(Helicobacter
pylori) 		PF01402
(RHH_1)
PF08753
(NikR_C) 		4 LYS A 140
LEU A 138
ALA A  66
LEU A  68
 None
 0.64A 1f86B-2wvfA:
undetectable		 1f86B-2wvfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 LYS A 719
LEU A 722
ALA A 702
LEU A 700
 None
 1.16A 1f86B-2x05A:
3.6		 1f86B-2x05A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		4 LYS A 146
LEU A 142
ALA A 118
LEU A 122
 None
 0.80A 1f86B-3dpiA:
undetectable		 1f86B-3dpiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		4 LYS A 426
LEU A 424
ALA A 366
LEU A 368
 None
 0.89A 1f86B-3dxbA:
undetectable		 1f86B-3dxbA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 LYS A  23
LEU A 254
ALA A  19
LEU A  16
 None
 1.21A 1f86B-3e7fA:
undetectable		 1f86B-3e7fA:
17.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
 0.78A 1f86B-3fc8A:
23.0		 1f86B-3fc8A:
99.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 LYS A 509
LEU A 511
ALA A 567
LEU A 565
 None
 1.28A 1f86B-3gsiA:
undetectable		 1f86B-3gsiA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		4 LYS A 397
LEU A 376
ALA A 393
LEU A 390
 None
 1.40A 1f86B-3hoaA:
undetectable		 1f86B-3hoaA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k49 MRNA-BINDING PROTEIN
PUF3

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 LYS A 802
LEU A 841
ALA A 805
LEU A 798
 None
 1.47A 1f86B-3k49A:
undetectable		 1f86B-3k49A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kae POSSIBLE PROTEIN OF
NUCLEAR SCAFFOLD

(Encephalitozoon
cuniculi) 		no annotation 4 LYS A  73
LEU A 119
ALA A  81
LEU A  85
 None
 1.31A 1f86B-3kaeA:
undetectable		 1f86B-3kaeA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwu MUNC13-1

(Rattus
norvegicus) 		PF00168
(C2) 		4 LYS A 704
LEU A 778
ALA A 703
LEU A 701
 CL  A 911 ( 3.2A)
None
None
None
 1.41A 1f86B-3kwuA:
2.7		 1f86B-3kwuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LYS A 351
LEU A 265
ALA A 350
LEU A 248
 None
 1.49A 1f86B-3ldrA:
undetectable		 1f86B-3ldrA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1

(Mycolicibacterium
smegmatis) 		PF02682
(CT_C_D) 		4 LYS B  52
LEU B  50
ALA B  13
LEU B  15
 None
 0.72A 1f86B-3mmlB:
undetectable		 1f86B-3mmlB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 LYS A 166
LEU A 162
ALA A 223
LEU A 219
 None
 1.16A 1f86B-3mpgA:
undetectable		 1f86B-3mpgA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		4 LYS A 326
LEU A 334
ALA A 321
LEU A 317
 None
 1.49A 1f86B-3mveA:
undetectable		 1f86B-3mveA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj9 NUCLEOSIDE
DIPHOSPHATE KINASE

(Campylobacter
jejuni) 		PF00334
(NDK) 		4 LYS A  83
LEU A  30
ALA A  80
LEU A  75
 None
 1.47A 1f86B-3pj9A:
undetectable		 1f86B-3pj9A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsi NIKR
NICKEL-RESPONSIVE
REGULATOR

(Helicobacter
pylori) 		no annotation 4 LYS B 140
LEU B 138
ALA B  66
LEU B  68
 None
 0.74A 1f86B-3qsiB:
undetectable		 1f86B-3qsiB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.41A 1f86B-3rb5A:
undetectable		 1f86B-3rb5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 LYS A 122
LEU A 118
ALA A 121
LEU A 154
 None
 1.42A 1f86B-4a1sA:
undetectable		 1f86B-4a1sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF02823
(ATP-synt_DE_N) 		4 LYS H 109
LEU H 105
ALA H 108
LEU H 104
 None
 1.44A 1f86B-4b2qH:
undetectable		 1f86B-4b2qH:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 LYS A  69
LEU A  73
ALA A 190
LEU A 186
 None
 1.15A 1f86B-4e4gA:
undetectable		 1f86B-4e4gA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		4 LYS A 248
LEU A 205
ALA A 249
LEU A 211
 None
 1.31A 1f86B-4ehjA:
undetectable		 1f86B-4ehjA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 LYS A 283
LEU A 279
ALA A 347
LEU A 343
 None
 1.27A 1f86B-4eviA:
undetectable		 1f86B-4eviA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 LYS A  42
LEU A  25
ALA A  38
LEU A  34
 None
 1.24A 1f86B-4jkzA:
undetectable		 1f86B-4jkzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		4 LYS A 119
LEU A 114
ALA A  77
LEU A  75
 None
 1.33A 1f86B-4kdzA:
undetectable		 1f86B-4kdzA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw7 ARSENIC
METHYLTRANSFERASE

(Cyanidioschyzon
sp. 5508) 		PF13847
(Methyltransf_31) 		4 LYS A 187
LEU A 183
ALA A 241
LEU A 237
 None
 1.24A 1f86B-4kw7A:
undetectable		 1f86B-4kw7A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9c F-BOX ONLY PROTEIN 7

(Homo sapiens) 		PF11566
(PI31_Prot_N) 		4 LYS A 220
LEU A 208
ALA A 221
LEU A 205
 None
 1.48A 1f86B-4l9cA:
undetectable		 1f86B-4l9cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LYS A 121
LEU A 114
ALA A 124
LEU A 177
 None
 1.02A 1f86B-4pqiA:
undetectable		 1f86B-4pqiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 LYS A  36
LEU A 167
ALA A  37
LEU A  39
 None
 1.50A 1f86B-4pzvA:
undetectable		 1f86B-4pzvA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM

(Vespa basalis) 		PF00151
(Lipase) 		4 LYS A 149
LEU A 153
ALA A 114
LEU A 155
 None
 1.35A 1f86B-4qnnA:
undetectable		 1f86B-4qnnA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3

(Homo sapiens) 		PF10421
(OAS1_C) 		4 LYS A  28
LEU A 116
ALA A  29
LEU A 133
 None
 1.30A 1f86B-4s3nA:
undetectable		 1f86B-4s3nA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 LYS A 152
LEU A 156
ALA A 144
LEU A 141
 None
 1.47A 1f86B-4uj6A:
undetectable		 1f86B-4uj6A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfc EXOSOME COMPLEX
EXONUCLEASE RRP6
EXOSOME COMPLEX
PROTEIN LRP1

(Saccharomyces
cerevisiae) 		PF04000
(Sas10_Utp3)
PF08066
(PMC2NT) 		4 LYS B  89
LEU A  96
ALA B  90
LEU A  99
 None
 1.41A 1f86B-4wfcB:
undetectable		 1f86B-4wfcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		4 LYS A 296
LEU A 299
ALA A 292
LEU A 340
 None
 1.22A 1f86B-4wr2A:
undetectable		 1f86B-4wr2A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.00A 1f86B-4xvxA:
undetectable		 1f86B-4xvxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae) 		PF13905
(Thioredoxin_8)
PF17127
(DUF5106) 		4 LYS A 292
LEU A 202
ALA A 179
LEU A 204
 None
 1.31A 1f86B-4yodA:
undetectable		 1f86B-4yodA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6y TBC1 DOMAIN FAMILY
MEMBER 7

(Homo sapiens) 		no annotation 4 LYS B 139
LEU B 135
ALA B 105
LEU B 109
 None
 1.19A 1f86B-4z6yB:
undetectable		 1f86B-4z6yB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1q AF1502

(Archaeoglobus
fulgidus) 		no annotation 4 LYS A  12
LEU A   8
ALA A  19
LEU A  23
 None
 1.21A 1f86B-5a1qA:
undetectable		 1f86B-5a1qA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 LYS A  90
LEU A  94
ALA A 211
LEU A 207
 None
 1.13A 1f86B-5abmA:
undetectable		 1f86B-5abmA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 LYS A  11
LEU A   7
ALA A  10
LEU A  43
 None
 1.21A 1f86B-5cwnA:
undetectable		 1f86B-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 LYS A  61
LEU A  57
ALA A  60
LEU A  93
 None
 1.09A 1f86B-5cwnA:
undetectable		 1f86B-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 LYS A 111
LEU A 107
ALA A 110
LEU A 143
 None
 1.12A 1f86B-5cwnA:
undetectable		 1f86B-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Streptococcus
suis) 		PF01791
(DeoC) 		4 LYS A 110
LEU A 106
ALA A 145
LEU A 141
 None
 1.28A 1f86B-5dbtA:
undetectable		 1f86B-5dbtA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		4 LYS A 174
LEU A 166
ALA A 203
LEU A 197
 None
 1.39A 1f86B-5jayA:
undetectable		 1f86B-5jayA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 LYS A 276
LEU A 290
ALA A 345
LEU A 343
 SO4  A 600 (-3.1A)
None
None
None
 1.10A 1f86B-5jm7A:
undetectable		 1f86B-5jm7A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 LYS A1288
LEU A1284
ALA A1287
LEU A1349
 None
EDO  A1421 ( 4.8A)
None
None
 1.48A 1f86B-5t03A:
undetectable		 1f86B-5t03A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 LYS A 544
LEU A 540
ALA A 611
LEU A 608
 None
 1.45A 1f86B-5t8vA:
undetectable		 1f86B-5t8vA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoc THIOREDOXIN
1,FORKHEAD BOX
PROTEIN H1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 LYS B 293
LEU B 291
ALA B 233
LEU B 235
 None
 0.93A 1f86B-5xocB:
undetectable		 1f86B-5xocB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ave ACID-SENSING ION
CHANNEL 1

(Gallus gallus) 		no annotation 4 LYS A 142
LEU A 109
ALA A 143
LEU A 119
 None
 1.33A 1f86B-6aveA:
2.3		 1f86B-6aveA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay1 NUCLEOSIDE
DIPHOSPHATE KINASE

(Helicobacter
pylori) 		PF00334
(NDK) 		4 LYS A  84
LEU A  31
ALA A  81
LEU A  76
 None
 1.47A 1f86B-6ay1A:
undetectable		 1f86B-6ay1A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Campylobacter
jejuni) 		no annotation 4 LYS A 176
LEU A 150
ALA A 177
LEU A 154
 None
 1.26A 1f86B-6bmaA:
undetectable		 1f86B-6bmaA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 LYS B  62
LEU B  60
ALA B  41
LEU B  43
 None
 0.81A 1f86B-6ckcB:
undetectable		 1f86B-6ckcB:
16.67