SIMILAR PATTERNS OF AMINO ACIDS FOR 1F86_A_T44A428_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LYS A 496
LEU A 492
ALA A 495
LEU A 322
 None
 1.42A 1f86A-1gz4A:
0.0		 1f86A-1gz4A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		4 LYS A 163
LEU A 159
ALA A 306
LEU A 302
 None
 1.47A 1f86A-1r1nA:
0.0		 1f86A-1r1nA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 LYS A 166
LEU A 162
ALA A 309
LEU A 305
 None
 1.40A 1f86A-1xvxA:
0.0		 1f86A-1xvxA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		4 LYS A  86
LEU A  90
ALA A  65
LEU A  61
 None
 1.39A 1f86A-2e1dA:
0.0		 1f86A-2e1dA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00018
(SH3_1) 		4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.48A 1f86A-2gqiA:
undetectable		 1f86A-2gqiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rqw BUD EMERGENCE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00018
(SH3_1) 		4 LYS A 170
LEU A 206
ALA A 168
LEU A 174
 None
 1.50A 1f86A-2rqwA:
0.0		 1f86A-2rqwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		4 LYS A 146
LEU A 142
ALA A 118
LEU A 122
 None
 1.07A 1f86A-3dpiA:
0.0		 1f86A-3dpiA:
15.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
 1.20A 1f86A-3fc8A:
24.3		 1f86A-3fc8A:
99.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LYS A 179
LEU A 175
ALA A 178
LEU A 174
 None
 1.27A 1f86A-3gd5A:
undetectable		 1f86A-3gd5A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		4 LYS A 144
LEU A 171
ALA A 145
LEU A 167
 None
 1.50A 1f86A-3mjoA:
undetectable		 1f86A-3mjoA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 LYS A 166
LEU A 162
ALA A 223
LEU A 219
 None
 1.43A 1f86A-3mpgA:
undetectable		 1f86A-3mpgA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LYS A 150
LEU A 143
ALA A 219
LEU A 193
 None
 1.50A 1f86A-3oa0A:
undetectable		 1f86A-3oa0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 LYS B 761
LEU B 757
ALA B 760
LEU B 754
 None
 1.39A 1f86A-3tixB:
undetectable		 1f86A-3tixB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw7 ARSENIC
METHYLTRANSFERASE

(Cyanidioschyzon
sp. 5508) 		PF13847
(Methyltransf_31) 		4 LYS A 187
LEU A 183
ALA A 241
LEU A 237
 None
 1.46A 1f86A-4kw7A:
undetectable		 1f86A-4kw7A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LYS A 121
LEU A 114
ALA A 124
LEU A 177
 None
 1.14A 1f86A-4pqiA:
undetectable		 1f86A-4pqiA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		4 LYS A  77
LEU A  73
ALA A  76
LEU A  72
 None
 1.42A 1f86A-4wmjA:
undetectable		 1f86A-4wmjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.13A 1f86A-4xvxA:
undetectable		 1f86A-4xvxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 LYS A   5
LEU A  14
ALA A  36
LEU A  18
 None
 1.46A 1f86A-4yweA:
undetectable		 1f86A-4yweA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1q AF1502

(Archaeoglobus
fulgidus) 		no annotation 4 LYS A  12
LEU A   8
ALA A  19
LEU A  23
 None
 1.48A 1f86A-5a1qA:
undetectable		 1f86A-5a1qA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 LYS A  61
LEU A  57
ALA A  60
LEU A  93
 None
 1.09A 1f86A-5cwnA:
undetectable		 1f86A-5cwnA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 LYS A1288
LEU A1284
ALA A1287
LEU A1349
 None
EDO  A1421 ( 4.8A)
None
None
 1.41A 1f86A-5t03A:
undetectable		 1f86A-5t03A:
10.09