SIMILAR PATTERNS OF AMINO ACIDS FOR 1F5L_A_AMRA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.27A 1f5lA-1a0jA:
15.7		 1f5lA-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
 0.37A 1f5lA-1a5iA:
35.8		 1f5lA-1a5iA:
39.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN

(Bos taurus) 		PF00089
(Trypsin) 		5 SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
0FG  C 301 ( 3.0A)
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
 0.57A 1f5lA-1afqC:
12.5		 1f5lA-1afqC:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLN A  72
GLY A 144
CYH A 421
GLY A 392
 FLC  A 756 (-3.6A)
None
SF4  A 755 (-2.3A)
None
 0.70A 1f5lA-1b0kA:
undetectable		 1f5lA-1b0kA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
 0.44A 1f5lA-1bqyA:
32.6		 1f5lA-1bqyA:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bru ELASTASE

(Sus scrofa) 		PF00089
(Trypsin) 		4 SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.45A 1f5lA-1bruP:
36.4		 1f5lA-1bruP:
36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		4 SER B 190
SER B 195
VAL B 213
GLY B 226
 None
 0.63A 1f5lA-1dlkB:
35.1		 1f5lA-1dlkB:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		4 SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.23A 1f5lA-1dlkB:
35.1		 1f5lA-1dlkB:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP B 189
SER B 190
SER B 195
GLY B 216
GLY B 226
 None
 0.36A 1f5lA-1ekbB:
36.4		 1f5lA-1ekbB:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 ASP A 611
SER A 612
SER A 617
VAL A 638
GLY A 641
GLY A 648
 None
None
SO4  A2001 ( 2.7A)
None
None
None
 0.37A 1f5lA-1elvA:
30.3		 1f5lA-1elvA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 216
GLY C 226
 None
 0.37A 1f5lA-1eptC:
12.5		 1f5lA-1eptC:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1euf DUODENASE

(Bos taurus) 		PF00089
(Trypsin) 		4 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.24A 1f5lA-1eufA:
32.6		 1f5lA-1eufA:
34.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fi8 NATURAL KILLER CELL
PROTEASE 1

(Rattus
norvegicus) 		PF00089
(Trypsin) 		4 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.41A 1f5lA-1fi8A:
10.5		 1f5lA-1fi8A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.30A 1f5lA-1fiwA:
36.6		 1f5lA-1fiwA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
 0.43A 1f5lA-1fizA:
36.3		 1f5lA-1fizA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
SO4  A 800 (-2.4A)
None
None
 0.61A 1f5lA-1fq3A:
9.7		 1f5lA-1fq3A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
 0.38A 1f5lA-1fxyA:
11.5		 1f5lA-1fxyA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
 0.32A 1f5lA-1h4wA:
14.7		 1f5lA-1h4wA:
38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 ASP E 189
SER E 190
SER E 195
VAL E 213
GLY E 216
GLY E 226
 None
 0.39A 1f5lA-1h9hE:
11.7		 1f5lA-1h9hE:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 None
 0.48A 1f5lA-1id5H:
34.9		 1f5lA-1id5H:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 ASP T 189
GLN T 192
SER T 195
VAL T 213
GLY T 216
GLY T 226
 ZEN  T   1 ( 3.8A)
None
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
 0.50A 1f5lA-1j17T:
15.2		 1f5lA-1j17T:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 None
 0.47A 1f5lA-1kigH:
32.3		 1f5lA-1kigH:
32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.36A 1f5lA-1mbqA:
16.5		 1f5lA-1mbqA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		6 SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A1222 (-2.9A)
None
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
 0.51A 1f5lA-1mbqA:
16.5		 1f5lA-1mbqA:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.35A 1f5lA-1npmA:
33.4		 1f5lA-1npmA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP H 189
GLN H 192
SER H 195
VAL H 213
GLY H 216
GLY H 226
 CR9  H 256 (-2.4A)
CR9  H 256 ( 4.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
 0.43A 1f5lA-1o5fH:
35.7		 1f5lA-1o5fH:
37.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.44A 1f5lA-1op2A:
10.4		 1f5lA-1op2A:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
 0.36A 1f5lA-1orfA:
11.7		 1f5lA-1orfA:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		6 ASP C 189
SER C 190
GLN C 192
SER C 195
GLY C 216
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
None
0G6  C 301 (-1.4A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
 0.46A 1f5lA-1pfxC:
31.9		 1f5lA-1pfxC:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 210
GLY A 213
GLY A 223
 ARG  A 703 (-2.0A)
ARG  A 703 (-2.5A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
ARG  A 703 ( 3.7A)
ARG  A 703 (-2.6A)
 0.38A 1f5lA-1pq5A:
34.0		 1f5lA-1pq5A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
 0.46A 1f5lA-1q3xA:
32.4		 1f5lA-1q3xA:
26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		4 ASP G 189
SER G 195
GLY G 216
GLY G 226
 None
 0.52A 1f5lA-1sgfG:
13.2		 1f5lA-1sgfG:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLN A 147
VAL A 153
GLY A  66
GLY A  85
 None
 0.75A 1f5lA-1uufA:
undetectable		 1f5lA-1uufA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1via SHIKIMATE KINASE

(Campylobacter
jejuni) 		PF01202
(SKI) 		4 ASP A  34
SER A  18
SER A  15
GLY A  81
 None
 0.78A 1f5lA-1viaA:
undetectable		 1f5lA-1viaA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.52A 1f5lA-1ym0A:
35.1		 1f5lA-1ym0A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zca G ALPHA I/12

(Mus musculus) 		PF00503
(G-alpha) 		4 SER A  66
SER A  69
GLY A 228
GLY A  62
 GDP  A 382 (-2.9A)
MG  A 383 ( 2.1A)
ALF  A 384 (-3.3A)
None
 0.65A 1f5lA-1zcaA:
undetectable		 1f5lA-1zcaA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
 0.43A 1f5lA-1zlrA:
35.2		 1f5lA-1zlrA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
SO4  A 301 (-2.8A)
None
None
 0.52A 1f5lA-2aipA:
10.5		 1f5lA-2aipA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLN A  86
GLY A 175
CYH A 503
GLY A 474
 None
None
SF4  A1000 (-2.2A)
None
 0.69A 1f5lA-2b3xA:
undetectable		 1f5lA-2b3xA:
13.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.30A 1f5lA-2eekA:
15.7		 1f5lA-2eekA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 226
 DT8  A 700 (-3.5A)
DT8  A 700 (-3.9A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
 0.39A 1f5lA-2ei8A:
33.5		 1f5lA-2ei8A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
 0.38A 1f5lA-2ei8A:
33.5		 1f5lA-2ei8A:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1n CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		4 GLN A  43
VAL A  89
GLY A  46
GLY A  94
 None
 0.71A 1f5lA-2f1nA:
undetectable		 1f5lA-2f1nA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 227
 None
 0.40A 1f5lA-2f91A:
36.8		 1f5lA-2f91A:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 ASP A 135
GLN A 118
GLY A 128
GLY A 137
 None
 0.77A 1f5lA-2i5gA:
undetectable		 1f5lA-2i5gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT

(Homo sapiens) 		PF00503
(G-alpha) 		4 SER A  44
SER A  47
GLY A 203
GLY A  40
 GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
 0.72A 1f5lA-2ik8A:
undetectable		 1f5lA-2ik8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 SER A 271
VAL A 276
GLY A 285
GLY A 273
 None
 0.79A 1f5lA-2iouA:
undetectable		 1f5lA-2iouA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.34A 1f5lA-2oq5A:
36.5		 1f5lA-2oq5A:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
 0.45A 1f5lA-2pksC:
12.3		 1f5lA-2pksC:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.43A 1f5lA-2psyA:
11.3		 1f5lA-2psyA:
35.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3f RAS-RELATED
GTP-BINDING PROTEIN
D

(Homo sapiens) 		PF04670
(Gtr1_RagA) 		4 SER A  54
SER A  57
GLY A 101
GLY A  50
 GNP  A 401 (-3.5A)
MG  A 301 ( 2.1A)
GNP  A 401 (-3.2A)
None
 0.69A 1f5lA-2q3fA:
undetectable		 1f5lA-2q3fA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP B 631
GLN B 634
SER B 637
VAL B 657
GLY B 660
GLY B 668
 None
 0.53A 1f5lA-2qy0B:
30.5		 1f5lA-2qy0B:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
 0.56A 1f5lA-2r0lA:
37.3		 1f5lA-2r0lA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
 0.22A 1f5lA-2r2wU:
47.0		 1f5lA-2r2wU:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
 None
 0.32A 1f5lA-2wpmS:
33.8		 1f5lA-2wpmS:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT

(Arabidopsis
thaliana) 		PF00503
(G-alpha) 		4 SER A  49
SER A  52
GLY A 221
GLY A  45
 GSP  A1382 (-3.4A)
MG  A1381 ( 2.0A)
GSP  A1382 (-3.4A)
None
 0.66A 1f5lA-2xtzA:
undetectable		 1f5lA-2xtzA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 203
SER A 204
GLN A 206
SER A 209
VAL A 227
GLY A 230
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
None
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
 0.43A 1f5lA-2zecA:
34.0		 1f5lA-2zecA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		6 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 4.1A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
 0.57A 1f5lA-3beuA:
31.1		 1f5lA-3beuA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		4 SER A  59
SER A  62
GLY A 225
GLY A  55
 GDP  A 775 (-3.4A)
MG  A 675 ( 2.7A)
None
None
 0.67A 1f5lA-3cx6A:
undetectable		 1f5lA-3cx6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A 165
VAL A 166
GLY A 196
GLY A 173
 None
 0.79A 1f5lA-3e60A:
undetectable		 1f5lA-3e60A:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
 0.49A 1f5lA-3f6uH:
33.1		 1f5lA-3f6uH:
35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP B 640
SER B 646
VAL B 666
GLY B 679
 None
 0.51A 1f5lA-3govB:
34.0		 1f5lA-3govB:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER B 646
VAL B 666
GLY B 669
GLY B 679
 None
 0.51A 1f5lA-3govB:
34.0		 1f5lA-3govB:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.48A 1f5lA-3gymA:
34.5		 1f5lA-3gymA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 GLN A 110
VAL A 166
GLY A 137
GLY A 198
 None
 0.74A 1f5lA-3h7lA:
undetectable		 1f5lA-3h7lA:
16.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
 None
 0.36A 1f5lA-3r3gB:
34.1		 1f5lA-3r3gB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		4 SER A  17
SER A  20
GLY A  64
GLY A  13
 GNP  A 500 (-3.6A)
MG  A 600 ( 2.0A)
GNP  A 500 (-3.8A)
None
 0.70A 1f5lA-3r7wA:
undetectable		 1f5lA-3r7wA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 209
GLY A 212
GLY A 223
 None
 0.51A 1f5lA-3s69A:
10.5		 1f5lA-3s69A:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 SER A  36
SER A  39
GLY A 149
GLY A  32
 GCP  A 801 (-4.0A)
MG  A 802 ( 2.0A)
GCP  A 801 (-3.6A)
None
 0.74A 1f5lA-3w6oA:
undetectable		 1f5lA-3w6oA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		5 ASP A 973
SER A 974
SER A 979
GLY A1000
GLY A1010
 None
 0.34A 1f5lA-3w94A:
36.6		 1f5lA-3w94A:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		4 SER A  19
SER A  22
GLY A  66
GLY A  15
 GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
 0.65A 1f5lA-3zjcA:
undetectable		 1f5lA-3zjcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		5 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.39A 1f5lA-4bxwA:
31.7		 1f5lA-4bxwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 ASP A 647
SER A 645
GLN A 588
GLY A 606
GLY A 625
 None
 1.26A 1f5lA-4ci8A:
undetectable		 1f5lA-4ci8A:
17.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.30A 1f5lA-4d9rA:
15.0		 1f5lA-4d9rA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 181
SER A 182
GLY A 208
GLY A 218
 None
 0.26A 1f5lA-4dgjA:
36.6		 1f5lA-4dgjA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
 None
 0.36A 1f5lA-4fxgH:
32.9		 1f5lA-4fxgH:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		5 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
 None
 0.59A 1f5lA-4gsoA:
undetectable		 1f5lA-4gsoA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
 None
 0.35A 1f5lA-4iw4E:
32.5		 1f5lA-4iw4E:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.41A 1f5lA-4k8yA:
15.2		 1f5lA-4k8yA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		4 ASP A 173
SER A 179
GLY A 196
GLY A 206
 None
 0.42A 1f5lA-4m7gA:
11.3		 1f5lA-4m7gA:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ASP A 432
GLN A 438
VAL A 481
GLY A 435
 None
 0.66A 1f5lA-4om9A:
15.2		 1f5lA-4om9A:
13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 3KM  A 900 (-2.9A)
3KM  A 900 (-2.9A)
None
3KM  A 900 (-3.6A)
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.2A)
 0.40A 1f5lA-4r0iA:
36.7		 1f5lA-4r0iA:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.37A 1f5lA-4wwyA:
15.7		 1f5lA-4wwyA:
37.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 216
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
 0.42A 1f5lA-4ylqH:
34.1		 1f5lA-4ylqH:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP E 189
GLN E 192
GLY E 216
GLY E 226
 None
 0.45A 1f5lA-5brrE:
38.1		 1f5lA-5brrE:
44.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		4 GLN A 109
VAL A 165
GLY A 136
GLY A 197
 None
 0.70A 1f5lA-5dgqA:
undetectable		 1f5lA-5dgqA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 4 ASP A 189
SER A 195
GLY A 216
GLY A 226
 None
 0.45A 1f5lA-5gvtA:
34.7		 1f5lA-5gvtA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 5 ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
 0.61A 1f5lA-5ms3A:
33.9		 1f5lA-5ms3A:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP I 519
VAL I 544
GLY I 547
GLY I 557
 None
 0.73A 1f5lA-5o32I:
32.5		 1f5lA-5o32I:
32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
 0.32A 1f5lA-5to3B:
35.4		 1f5lA-5to3B:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.73A 1f5lA-5ubkA:
undetectable		 1f5lA-5ubkA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 6 ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 656
GLY A 663
 None
 0.41A 1f5lA-5ubmA:
30.5		 1f5lA-5ubmA:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C

(Paenibacillus
sp. A11-2) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 SER A 162
VAL A 215
GLY A 200
GLY A 213
 None
 0.73A 1f5lA-5xdeA:
undetectable		 1f5lA-5xdeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 5 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
 None
 0.70A 1f5lA-5xrfA:
9.9		 1f5lA-5xrfA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 4 SER B  86
SER B  89
GLY B 181
GLY B  82
 GDP  B 801 (-4.1A)
MG  B 804 ( 2.1A)
BEF  B 802 (-3.3A)
None
 0.73A 1f5lA-5yewB:
undetectable		 1f5lA-5yewB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus) 		no annotation 4 SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.40A 1f5lA-5zfhA:
12.0		 1f5lA-5zfhA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT

(Homo sapiens) 		no annotation 4 SER A  51
SER A  54
GLY A 226
GLY A  47
 GDP  A 401 (-3.4A)
MG  A 402 ( 2.1A)
None
None
 0.64A 1f5lA-6au6A:
undetectable		 1f5lA-6au6A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 5 ASP B 189
GLN B 192
SER B 195
GLY B 216
GLY B 226
 BEN  B 301 (-2.7A)
SO4  B 304 (-4.4A)
SO4  B 304 ( 2.5A)
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
 0.51A 1f5lA-6b74B:
36.7		 1f5lA-6b74B:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 4 SER A  57
GLY A  32
CYH A  36
GLY A  29
 None
 0.71A 1f5lA-6cauA:
undetectable		 1f5lA-6cauA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 4 GLN A 110
VAL A 166
GLY A 137
GLY A 198
 None
 0.73A 1f5lA-6gdtA:
undetectable		 1f5lA-6gdtA:
undetectable