SIMILAR PATTERNS OF AMINO ACIDS FOR 1EVE_A_E20A2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 121
GLU A 202
LEU A 289
PHE A 295
HIS A 447
 None
 1.31A 1eveA-1b41A:
59.3		 1eveA-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 122
GLU A 202
PHE A 338
TYR A 341
HIS A 447
 None
 0.84A 1eveA-1b41A:
59.3		 1eveA-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		6 GLY A 122
TYR A 124
GLU A 202
TRP A 286
PHE A 338
HIS A 447
 None
 1.17A 1eveA-1b41A:
59.3		 1eveA-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		6 TRP A  86
GLY A 121
GLU A 202
PHE A 338
TYR A 341
HIS A 447
 None
 0.67A 1eveA-1b41A:
59.3		 1eveA-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		8 TRP A  86
GLY A 121
TYR A 124
GLU A 202
TRP A 286
LEU A 289
PHE A 338
HIS A 447
 None
 0.50A 1eveA-1b41A:
59.3		 1eveA-1b41A:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		6 GLY A 121
GLU A 202
TRP A 286
LEU A 289
PHE A 295
HIS A 447
 None
 1.21A 1eveA-1c2oA:
59.4		 1eveA-1c2oA:
58.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 GLY A 122
TYR A 124
PHE A 338
TYR A 341
HIS A 447
 None
 1.28A 1eveA-1c2oA:
59.4		 1eveA-1c2oA:
58.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		9 TRP A  86
GLY A 121
TYR A 124
GLU A 202
TRP A 286
LEU A 289
PHE A 338
TYR A 341
HIS A 447
 None
 0.56A 1eveA-1c2oA:
59.4		 1eveA-1c2oA:
58.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		6 GLY A 118
TYR A 121
GLU A 199
TRP A 279
LEU A 282
PHE A 288
 SAF  A1998 ( 3.5A)
None
SAF  A1998 (-3.5A)
None
None
EMM  A1999 (-4.3A)
 0.99A 1eveA-1gqrA:
68.9		 1eveA-1gqrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		6 GLY A 119
TYR A 121
TRP A 279
PHE A 331
TYR A 334
HIS A 440
 EMM  A1999 (-3.5A)
None
None
EMM  A1999 (-4.7A)
None
EMM  A1999 ( 3.8A)
 1.35A 1eveA-1gqrA:
68.9		 1eveA-1gqrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		10 TRP A  84
GLY A 118
TYR A 121
GLU A 199
TRP A 279
LEU A 282
PHE A 330
PHE A 331
TYR A 334
HIS A 440
 SAF  A1998 (-3.8A)
SAF  A1998 ( 3.5A)
None
SAF  A1998 (-3.5A)
None
None
SAF  A1998 (-3.1A)
EMM  A1999 (-4.7A)
None
EMM  A1999 ( 3.8A)
 0.61A 1eveA-1gqrA:
68.9		 1eveA-1gqrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3k CREATININASE

(Pseudomonas
putida) 		PF02633
(Creatininase) 		5 GLY A 119
TYR A 153
GLU A  34
LEU A 242
HIS A  36
 None
None
ZN  A 300 (-2.5A)
None
ZN  A 301 (-3.3A)
 1.48A 1eveA-1q3kA:
undetectable		 1eveA-1q3kA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		6 GLY A 151
GLU A 237
TRP A 321
PHE A 371
TYR A 374
HIS A 480
 SO4  A 593 (-3.4A)
I40  A 997 (-4.2A)
None
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 1.49A 1eveA-1qonA:
60.7		 1eveA-1qonA:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		7 TRP A  83
GLY A 150
GLU A 237
TRP A 321
PHE A 371
TYR A 374
HIS A 480
 I40  A 997 (-3.2A)
I40  A 997 (-3.9A)
I40  A 997 (-4.2A)
None
I40  A 997 (-4.9A)
I40  A 997 ( 3.9A)
SO4  A 593 (-4.1A)
 0.73A 1eveA-1qonA:
60.7		 1eveA-1qonA:
38.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		5 GLY A  40
LEU A  98
PHE A  37
TYR A  89
HIS A  38
 None
 1.45A 1eveA-2dfaA:
1.9		 1eveA-2dfaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nab ZINC FINGER PROTEIN
496

(Mus musculus) 		no annotation 5 GLY A  18
PHE A  27
PHE A  21
TYR A  12
HIS A  30
 None
None
None
None
ZN  A 101 (-2.9A)
 1.40A 1eveA-2nabA:
undetectable		 1eveA-2nabA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 GLY A 304
TYR A  95
LEU A 130
PHE A 122
HIS A 102
 None
None
None
None
CU  A1001 (-3.2A)
 1.49A 1eveA-4j3qA:
undetectable		 1eveA-4j3qA:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		7 GLY A 118
TYR A 121
GLU A 199
TRP A 279
LEU A 282
PHE A 288
HIS A 440
 None
 1.23A 1eveA-4qwwA:
63.7		 1eveA-4qwwA:
65.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 GLY A 119
TYR A 121
PHE A 331
TYR A 334
HIS A 440
 None
 1.26A 1eveA-4qwwA:
63.7		 1eveA-4qwwA:
65.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		9 TRP A  84
GLY A 118
TYR A 121
GLU A 199
TRP A 279
LEU A 282
PHE A 331
TYR A 334
HIS A 440
 None
 0.65A 1eveA-4qwwA:
63.7		 1eveA-4qwwA:
65.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		6 TRP A  82
GLY A 116
GLU A 197
PHE A 329
TYR A 332
HIS A 438
 40V  A1001 (-3.3A)
40V  A1001 (-3.2A)
40V  A1001 (-3.2A)
40V  A1001 (-4.0A)
40V  A1001 (-3.8A)
40V  A1001 (-3.6A)
 0.32A 1eveA-4xiiA:
65.8		 1eveA-4xiiA:
52.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la7 HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 TRP A 365
GLY A 370
LEU A 464
PHE A 531
TYR A 529
 None
 1.24A 1eveA-5la7A:
0.2		 1eveA-5la7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4w CULLIN-2

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 GLY A 183
LEU A 144
PHE A 207
PHE A 188
TYR A 203
 None
 1.36A 1eveA-5n4wA:
undetectable		 1eveA-5n4wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 5 GLY A 304
TYR A  95
LEU A 130
PHE A 122
HIS A 102
 None
None
None
None
CU  A2001 (-3.3A)
 1.50A 1eveA-5or4A:
undetectable		 1eveA-5or4A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtz YEATS
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		no annotation 5 GLY A  42
GLU A  39
LEU A 118
PHE A  34
TYR A  33
 None
 1.20A 1eveA-5xtzA:
undetectable		 1eveA-5xtzA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y82 MEMBRANE PROTEIN
INSERTASE YIDC

(Thermotoga
maritima) 		no annotation 5 GLY D  71
LEU D  46
PHE D 126
PHE D 116
TYR D  42
 None
 1.39A 1eveA-5y82D:
undetectable		 1eveA-5y82D:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 6 GLY A 280
TYR A 282
TRP A 441
PHE A 490
TYR A 493
HIS A 600
 SEB  A 360 ( 3.0A)
None
None
None
None
SEB  A 360 ( 4.2A)
 1.15A 1eveA-5ydjA:
66.7		 1eveA-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 9 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
LEU A 444
PHE A 490
TYR A 493
HIS A 600
 SEB  A 360 ( 4.2A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 3.3A)
None
SO4  A 816 (-4.0A)
None
None
SEB  A 360 ( 4.2A)
 0.73A 1eveA-5ydjA:
66.7		 1eveA-5ydjA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 9 TRP A 245
GLY A 279
TYR A 282
GLU A 359
TRP A 441
LEU A 444
PHE A 490
TYR A 493
HIS A 600
 None
 0.78A 1eveA-6arxA:
64.4		 1eveA-6arxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 GLY A 420
GLU A 397
LEU A 216
TYR A 357
HIS A 359
 None
None
None
FAD  A 501 (-4.3A)
None
 1.14A 1eveA-6bz0A:
undetectable		 1eveA-6bz0A:
9.68