SIMILAR PATTERNS OF AMINO ACIDS FOR 1ETR_H_MITH1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar)
PF00089
(Trypsin)
8 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
SO4  A 248 (-3.9A)
None
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
0.56A 1etrH-1a0jA:
33.8
1etrH-1a0jA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR


(Desmodus
rotundus)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
0GJ  A 245 (-2.7A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
0.68A 1etrH-1a5iA:
32.8
1etrH-1a5iA:
33.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN


(Bos taurus)
PF00089
(Trypsin)
5 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
0FG  C 301 ( 3.0A)
None
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
0.43A 1etrH-1afqC:
8.5
1etrH-1afqC:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR


(Trimeresurus
stejnegeri)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
0GJ  A   1 ( 2.7A)
0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
0.61A 1etrH-1bqyA:
32.2
1etrH-1bqyA:
32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bru ELASTASE

(Sus scrofa)
PF00089
(Trypsin)
5 HIS P  57
LEU P  99
SER P 195
VAL P 213
GLY P 216
1NB  P   1 (-3.9A)
None
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
0.77A 1etrH-1bruP:
34.5
1etrH-1bruP:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus)
PF00089
(Trypsin)
6 HIS B  57
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
None
0.60A 1etrH-1dlkB:
34.6
1etrH-1dlkB:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekb ENTEROPEPTIDASE

(Bos taurus)
PF00089
(Trypsin)
5 HIS B  57
ASP B 189
SER B 195
GLY B 216
GLY B 226
None
0.67A 1etrH-1ekbB:
35.6
1etrH-1ekbB:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
7 HIS A 460
ASP A 611
SER A 617
VAL A 638
TRP A 640
GLY A 641
GLY A 648
SO4  A2001 ( 3.9A)
None
SO4  A2001 ( 2.7A)
None
None
None
None
0.63A 1etrH-1elvA:
30.8
1etrH-1elvA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa)
PF00089
(Trypsin)
8 HIS A  57
LEU B  99
ASP C 189
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
None
0.51A 1etrH-1eptA:
2.2
1etrH-1eptA:
10.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1euf DUODENASE

(Bos taurus)
PF00089
(Trypsin)
5 HIS A  57
LEU A  99
SER A 195
VAL A 213
GLY A 216
None
0.63A 1etrH-1eufA:
32.6
1etrH-1eufA:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN


(Ovis aries)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
0.60A 1etrH-1fiwA:
34.7
1etrH-1fiwA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN


(Sus scrofa)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.54A 1etrH-1fizA:
34.1
1etrH-1fizA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA


(Homo sapiens)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
0G6  A   1 (-2.7A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
0.67A 1etrH-1fxyA:
32.6
1etrH-1fxyA:
38.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpz COMPLEMENT C1R
COMPONENT


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 HIS A 485
SER A 637
VAL A 657
GLY A 660
GLY A 668
None
0.83A 1etrH-1gpzA:
27.2
1etrH-1gpzA:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens)
PF00089
(Trypsin)
6 HIS A  57
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.59A 1etrH-1gvlA:
24.8
1etrH-1gvlA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens)
PF00089
(Trypsin)
8 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
None
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
0.45A 1etrH-1h4wA:
34.1
1etrH-1h4wA:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa)
PF00089
(Trypsin)
8 HIS E  57
LEU E  99
ASP E 189
SER E 195
VAL E 213
TRP E 215
GLY E 216
GLY E 226
None
0.59A 1etrH-1h9hE:
33.8
1etrH-1h9hE:
38.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus)
PF00089
(Trypsin)
7 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
None
0.69A 1etrH-1id5H:
43.2
1etrH-1id5H:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus)
PF00089
(Trypsin)
6 LEU H  99
ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
None
0.94A 1etrH-1id5H:
43.2
1etrH-1id5H:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus)
PF00089
(Trypsin)
7 HIS T  57
ASP T 189
SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 226
SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.49A 1etrH-1j17T:
34.4
1etrH-1j17T:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus)
PF00089
(Trypsin)
7 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
None
0.58A 1etrH-1kigH:
34.5
1etrH-1kigH:
40.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN


(Escherichia
coli)
PF01375
(Enterotoxin_a)
5 TYR A  86
TRP A 127
LEU A  22
GLU A 144
GLY A  20
None
0.96A 1etrH-1lt3A:
undetectable
1etrH-1lt3A:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
0.42A 1etrH-1mbqA:
33.6
1etrH-1mbqA:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus)
PF00089
(Trypsin)
PF09396
(Thrombin_light)
8 HIS K  57
TYR K  60
TRP K  60
LEU K  99
SER K 195
TRP K 215
GLY K 216
GLY K 226
None
0.97A 1etrH-1mkxK:
37.1
1etrH-1mkxK:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus)
PF00089
(Trypsin)
PF09396
(Thrombin_light)
8 HIS K  57
TYR K  60
TRP K  60
LEU K  99
SER K 195
VAL K 213
TRP K 215
GLY K 226
None
0.62A 1etrH-1mkxK:
37.1
1etrH-1mkxK:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.65A 1etrH-1npmA:
33.1
1etrH-1npmA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN


(Homo sapiens)
PF00089
(Trypsin)
7 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
CR9  H 256 (-3.9A)
CR9  H 256 (-2.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
None
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
0.56A 1etrH-1o5fH:
35.0
1etrH-1o5fH:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1op2 VENOM SERINE
PROTEINASE


(Deinagkistrodon
acutus)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.57A 1etrH-1op2A:
31.2
1etrH-1op2A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1orf GRANZYME A

(Homo sapiens)
PF00089
(Trypsin)
5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
0G6  A   1 (-2.7A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
0.65A 1etrH-1orfA:
31.3
1etrH-1orfA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa)
PF00089
(Trypsin)
6 HIS C  57
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
0G6  C 301 (-2.5A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
0.71A 1etrH-1pfxC:
33.0
1etrH-1pfxC:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum)
PF00089
(Trypsin)
7 HIS A  56
ASP A 189
SER A 195
VAL A 210
TRP A 212
GLY A 213
GLY A 223
ARG  A 703 (-4.3A)
ARG  A 703 (-2.0A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
None
ARG  A 703 ( 3.7A)
ARG  A 703 (-2.6A)
0.54A 1etrH-1pq5A:
32.5
1etrH-1pq5A:
35.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
7 HIS A 483
ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
None
NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
0.44A 1etrH-1q3xA:
34.4
1etrH-1q3xA:
27.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus)
PF00089
(Trypsin)
6 HIS G  57
ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
None
0.70A 1etrH-1sgfG:
32.2
1etrH-1sgfG:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1spj KALLIKREIN 1

(Homo sapiens)
PF00089
(Trypsin)
5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
None
0.65A 1etrH-1spjA:
32.9
1etrH-1spjA:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B


(Eisenia fetida)
PF00089
(Trypsin)
8 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.57A 1etrH-1ym0A:
35.7
1etrH-1ym0A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
6 HIS A 483
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
None
0.68A 1etrH-1zjkA:
31.2
1etrH-1zjkA:
23.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI


(Homo sapiens)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
368  A 901 (-4.0A)
368  A 901 (-2.8A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
0.43A 1etrH-1zlrA:
34.8
1etrH-1zlrA:
37.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix)
PF00089
(Trypsin)
5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
SO4  A 301 (-3.8A)
None
SO4  A 301 (-2.8A)
None
None
0.79A 1etrH-2aipA:
30.4
1etrH-2aipA:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96)
PF00082
(Peptidase_S8)
5 TYR A 213
TRP A 212
VAL A  95
GLY A 100
GLY A 102
None
0.96A 1etrH-2b6nA:
undetectable
1etrH-2b6nA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE


(Thermus
thermophilus)
PF01613
(Flavin_Reduct)
5 LEU A  70
GLU A  92
VAL A 102
GLY A  98
GLY A 129
None
0.93A 1etrH-2ecrA:
undetectable
1etrH-2ecrA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
0.43A 1etrH-2eekA:
33.0
1etrH-2eekA:
38.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN


(Homo sapiens)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.60A 1etrH-2ei8A:
35.3
1etrH-2ei8A:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN


(Astacus
leptodactylus)
PF00089
(Trypsin)
8 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 227
None
0.50A 1etrH-2f91A:
34.4
1etrH-2f91A:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C


(Rattus
norvegicus)
PF00089
(Trypsin)
6 HIS B  57
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
None
0.69A 1etrH-2jetB:
13.6
1etrH-2jetB:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens)
PF00089
(Trypsin)
PF00092
(VWA)
5 HIS A 487
SER A 659
VAL A 677
TRP A 679
GLY A 680
None
0.59A 1etrH-2odpA:
23.0
1etrH-2odpA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E


(Homo sapiens)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
0.45A 1etrH-2oq5A:
34.6
1etrH-2oq5A:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa)
PF00089
(Trypsin)
5 HIS A  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
0.51A 1etrH-2pkaA:
6.9
1etrH-2pkaA:
16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pks THROMBIN HEAVY CHAIN
FRAGMENT


(Homo sapiens)
PF00089
(Trypsin)
7 ASP C 229
GLU C 232
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 268
G44  C 101 (-2.6A)
None
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
0.65A 1etrH-2pksC:
12.1
1etrH-2pksC:
38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.71A 1etrH-2psyA:
33.5
1etrH-2psyA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT


(Homo sapiens)
PF00089
(Trypsin)
7 HIS B 485
ASP B 631
SER B 637
VAL B 657
TRP B 659
GLY B 660
GLY B 668
None
0.47A 1etrH-2qy0B:
32.8
1etrH-2qy0B:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR


(Homo sapiens)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.46A 1etrH-2r0lA:
34.7
1etrH-2r0lA:
32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE


(Homo sapiens)
PF00089
(Trypsin)
6 HIS U  57
ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
4PG  U 300 (-3.9A)
4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
0.42A 1etrH-2r2wU:
35.1
1etrH-2r2wU:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE


(Homo sapiens)
PF00089
(Trypsin)
6 HIS U  57
SER U 195
VAL U 213
TRP U 215
GLY U 216
GLY U 226
4PG  U 300 (-3.9A)
4PG  U 300 (-3.5A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
0.51A 1etrH-2r2wU:
35.1
1etrH-2r2wU:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN


(Homo sapiens)
PF00089
(Trypsin)
6 HIS S  57
ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
None
0.72A 1etrH-2wpmS:
34.5
1etrH-2wpmS:
39.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens)
PF00089
(Trypsin)
7 HIS A  59
ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
None
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.55A 1etrH-2zecA:
33.3
1etrH-2zecA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
SO4  A 246 ( 3.8A)
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
0.49A 1etrH-3beuA:
31.3
1etrH-3beuA:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
7 ASP H 189
GLU H 192
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 ( 4.0A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.66A 1etrH-3f6uH:
35.2
1etrH-3f6uH:
41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
7 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-3.2A)
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.67A 1etrH-3f6uH:
35.2
1etrH-3f6uH:
41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens)
PF00089
(Trypsin)
7 HIS B 490
ASP B 640
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
None
0.55A 1etrH-3govB:
36.0
1etrH-3govB:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.66A 1etrH-3gymA:
33.8
1etrH-3gymA:
37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxp PRETHROMBIN-1

(Homo sapiens)
PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light)
5 HIS A 457
TYR A 460
LEU A 499
VAL A 613
GLY A 626
None
0.57A 1etrH-3nxpA:
29.6
1etrH-3nxpA:
87.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens)
PF00089
(Trypsin)
10 HIS B  57
TYR B  60
LEU B  99
ASP B 189
GLU B 192
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
None
0.78A 1etrH-3r3gB:
43.5
1etrH-3r3gB:
88.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens)
PF00089
(Trypsin)
6 TYR B  60
TRP B  60
LEU B  99
ASP B 189
GLY B 216
GLY B 226
None
0.79A 1etrH-3r3gB:
43.5
1etrH-3r3gB:
88.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4


(Homo sapiens)
PF04130
(Spc97_Spc98)
5 LEU A 197
GLU A 304
SER A 188
GLY A 194
GLY A 280
None
0.85A 1etrH-3ripA:
undetectable
1etrH-3ripA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE


(Gloydius
saxatilis)
PF00089
(Trypsin)
6 HIS A  56
ASP A 189
SER A 195
VAL A 209
GLY A 212
GLY A 223
None
0.53A 1etrH-3s69A:
31.3
1etrH-3s69A:
32.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes)
PF00089
(Trypsin)
5 HIS A 836
ASP A 973
SER A 979
GLY A1000
GLY A1010
None
0.54A 1etrH-3w94A:
36.1
1etrH-3w94A:
35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bxw FACTOR XA

(Pseudonaja
textilis)
PF00089
(Trypsin)
PF14670
(FXa_inhibition)
6 HIS A 211
ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
0.69A 1etrH-4bxwA:
32.9
1etrH-4bxwA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 HIS A  41
ASP A 181
SER A 187
GLY A 208
GLY A 218
None
0.72A 1etrH-4dgjA:
36.3
1etrH-4dgjA:
35.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus)
PF00082
(Peptidase_S8)
5 TYR A 209
TRP A 208
VAL A  96
GLY A 101
GLY A 103
None
0.93A 1etrH-4dztA:
undetectable
1etrH-4dztA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME


(Gloydius halys)
PF00089
(Trypsin)
5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
None
0.62A 1etrH-4e7nA:
31.0
1etrH-4e7nA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN


(Homo sapiens)
PF00089
(Trypsin)
6 HIS H 483
ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
None
0.55A 1etrH-4fxgH:
34.7
1etrH-4fxgH:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1


(Bothrops
jararacussu)
PF00089
(Trypsin)
5 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
None
0.62A 1etrH-4gsoA:
undetectable
1etrH-4gsoA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h4f CHYMOTRYPSIN-C

(Homo sapiens)
PF00089
(Trypsin)
5 HIS A  57
LEU A  99
SER A 195
VAL A 213
GLY A 216
None
0.59A 1etrH-4h4fA:
34.4
1etrH-4h4fA:
34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzh PROTHROMBIN

(Homo sapiens)
PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light)
6 HIS A 363
TYR A 367
TRP A 370
LEU A 416
VAL A 545
GLY A 558
None
0.93A 1etrH-4hzhA:
29.8
1etrH-4hzhA:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzh PROTHROMBIN

(Homo sapiens)
PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light)
6 HIS A 363
TYR A 367
TRP A 370
VAL A 545
GLY A 548
GLY A 558
None
1.29A 1etrH-4hzhA:
29.8
1etrH-4hzhA:
86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3


(Homo sapiens)
PF00089
(Trypsin)
7 HIS E 478
ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 680
None
0.70A 1etrH-4iw4E:
32.7
1etrH-4iw4E:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.57A 1etrH-4k8yA:
32.5
1etrH-4k8yA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens)
PF00089
(Trypsin)
6 LEU A  99
ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.86A 1etrH-4k8yA:
32.5
1etrH-4k8yA:
32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 HIS A 497
VAL A 684
TRP A 686
GLY A 687
GLY A 699
None
0.54A 1etrH-4kkdA:
29.5
1etrH-4kkdA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk4 VESB PROTEASE

(Vibrio cholerae)
PF00089
(Trypsin)
6 HIS A  78
LEU A 122
VAL A 237
TRP A 239
GLY A 240
GLY A 251
None
0.64A 1etrH-4lk4A:
27.3
1etrH-4lk4A:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7g TRYPSIN-LIKE
PROTEASE


(Saccharopolyspora
erythraea)
PF00089
(Trypsin)
6 HIS A  42
ASP A 173
SER A 179
TRP A 195
GLY A 196
GLY A 206
None
0.43A 1etrH-4m7gA:
32.3
1etrH-4m7gA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nff KALLIKREIN-2

(Homo sapiens)
PF00089
(Trypsin)
5 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
0G6  A 301 (-2.7A)
0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
0.82A 1etrH-4nffA:
33.4
1etrH-4nffA:
34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN


(Homo sapiens)
PF00089
(Trypsin)
7 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
3KM  A 900 ( 4.4A)
3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.2A)
0.50A 1etrH-4r0iA:
36.1
1etrH-4r0iA:
35.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens)
PF00089
(Trypsin)
8 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.70A 1etrH-4wwyA:
33.9
1etrH-4wwyA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII


(Homo sapiens)
PF00089
(Trypsin)
7 HIS H  57
ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0Z7  H 501 (-2.6A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
0.63A 1etrH-4ylqH:
34.5
1etrH-4ylqH:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR


(Homo sapiens)
PF00089
(Trypsin)
5 HIS E  57
ASP E 189
TRP E 215
GLY E 216
GLY E 226
None
0.50A 1etrH-5brrE:
34.9
1etrH-5brrE:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI


(Homo sapiens)
PF00024
(PAN_1)
PF00089
(Trypsin)
5 HIS A 413
SER A 557
TRP A 577
GLY A 578
GLY A 588
None
0.80A 1etrH-5eodA:
27.5
1etrH-5eodA:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN


(Homo sapiens)
PF00089
(Trypsin)
6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.47A 1etrH-5f8zA:
34.7
1etrH-5f8zA:
39.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus)
no annotation 5 HIS A  57
ASP A 189
SER A 195
GLY A 216
GLY A 226
None
0.65A 1etrH-5gvtA:
34.6
1etrH-5gvtA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens)
no annotation 6 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.58A 1etrH-5ms3A:
32.9
1etrH-5ms3A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA


(Methanothermococcus
thermolithotrophicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 HIS B 199
TYR B 200
LEU B 178
ASP B 169
GLY B 180
None
0.93A 1etrH-5n1qB:
undetectable
1etrH-5n1qB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT


(Methanotorris
formicicus)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 HIS B 199
TYR B 200
LEU B 178
ASP B 169
GLY B 180
None
0.88A 1etrH-5n28B:
undetectable
1etrH-5n28B:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o32 COMPLEMENT FACTOR I

(Homo sapiens)
PF00089
(Trypsin)
5 ASP I 519
VAL I 544
TRP I 546
GLY I 547
GLY I 557
None
0.86A 1etrH-5o32I:
31.0
1etrH-5o32I:
34.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o32 COMPLEMENT FACTOR I

(Homo sapiens)
PF00089
(Trypsin)
5 HIS I 380
VAL I 544
TRP I 546
GLY I 547
GLY I 557
None
0.61A 1etrH-5o32I:
31.0
1etrH-5o32I:
34.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN


(Homo sapiens)
PF00089
(Trypsin)
PF09064
(Tme5_EGF_like)
8 HIS B  58
TYR B  62
LEU B 111
ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
0G6  B 501 (-2.5A)
0G6  B 501 (-3.7A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
0.60A 1etrH-5to3B:
44.1
1etrH-5to3B:
79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN


(Homo sapiens)
PF00089
(Trypsin)
PF09064
(Tme5_EGF_like)
6 TYR B  62
TRP B  65
LEU B 111
ASP B 214
GLY B 243
GLY B 253
0G6  B 501 (-3.7A)
0G6  B 501 (-4.8A)
0G6  B 501 ( 3.8A)
0G6  B 501 (-2.9A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
0.73A 1etrH-5to3B:
44.1
1etrH-5to3B:
79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT


(Homo sapiens)
no annotation 7 HIS A 475
ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
None
0.71A 1etrH-5ubmA:
31.3
1etrH-5ubmA:
34.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36


(Deinagkistrodon
acutus)
no annotation 6 HIS A  67
ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
None
0.67A 1etrH-5xrfA:
29.7
1etrH-5xrfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus)
no annotation 6 HIS A  57
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.47A 1etrH-5zfhA:
32.8
1etrH-5zfhA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII


(Homo sapiens)
no annotation 6 HIS B  57
ASP B 189
SER B 195
TRP B 215
GLY B 216
GLY B 226
SO4  B 304 (-3.8A)
BEN  B 301 (-2.7A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
0.58A 1etrH-6b74B:
34.4
1etrH-6b74B:
15.66