SIMILAR PATTERNS OF AMINO ACIDS FOR 1ETB_2_T442129_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 LEU A 448
THR A 442
ALA A 438
LEU A 434
 None
 1.18A 1etb2-1dgjA:
0.0		 1etb2-1dgjA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 LEU P 268
THR P 260
ALA P 264
LEU P 270
 None
 1.27A 1etb2-1e33P:
undetectable		 1etb2-1e33P:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 LEU A 385
GLU A 375
THR A 341
ALA A 397
 None
 0.99A 1etb2-1g7cA:
0.0		 1etb2-1g7cA:
15.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
 None
 0.56A 1etb2-1gkeA:
21.2		 1etb2-1gkeA:
82.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
GLU A  54
THR A 106
ALA A 108
 None
 0.54A 1etb2-1gkeA:
21.2		 1etb2-1gkeA:
82.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1h PRECORRIN-8X
METHYLMUTASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF02570
(CbiC) 		4 GLU A 147
THR A 140
ALA A 118
LEU A 108
 None
 1.26A 1etb2-1i1hA:
0.0		 1etb2-1i1hA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 510
GLU A 513
THR A 576
LEU A 507
 None
 1.23A 1etb2-1iq0A:
undetectable		 1etb2-1iq0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		4 LEU A  59
GLU A 111
ALA A 107
LEU A 105
 None
 1.08A 1etb2-1iuhA:
undetectable		 1etb2-1iuhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji5 DLP-1

(Bacillus
anthracis) 		PF00210
(Ferritin) 		4 LYS A  41
LEU A  45
THR A  37
LEU A  23
 None
 1.08A 1etb2-1ji5A:
undetectable		 1etb2-1ji5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLU A 392
THR A 371
ALA A 348
LEU A 389
 None
 1.13A 1etb2-1kfiA:
0.0		 1etb2-1kfiA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLU A 375
THR A 354
ALA A 331
LEU A 372
 None
 1.11A 1etb2-1lxtA:
undetectable		 1etb2-1lxtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1q DPS PROTEIN

(Brevibacillus
brevis) 		PF00210
(Ferritin) 		4 LYS A  45
LEU A  49
THR A  41
LEU A  27
 None
 1.10A 1etb2-1n1qA:
undetectable		 1etb2-1n1qA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT

(Methanothermobacter
thermautotrophicus) 		PF01873
(eIF-5_eIF-2B) 		4 LYS A 122
GLU A 124
ALA A 130
LEU A 132
 None
 1.21A 1etb2-1neeA:
undetectable		 1etb2-1neeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5u NOVEL THERMOTOGA
MARITIMA ENZYME
TM1112

(Thermotoga
maritima) 		PF05899
(Cupin_3) 		4 LYS A  77
LEU A  79
GLU A  30
THR A  51
 None
 1.02A 1etb2-1o5uA:
undetectable		 1etb2-1o5uA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
 None
 0.47A 1etb2-1sn2A:
20.8		 1etb2-1sn2A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
 None
 0.49A 1etb2-1tfpA:
18.8		 1etb2-1tfpA:
73.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LYS A 324
LEU A 285
GLU A 327
ALA A 323
 None
 0.94A 1etb2-1ufaA:
undetectable		 1etb2-1ufaA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 GLU A  57
THR A 108
ALA A  54
LEU A  52
 None
 1.08A 1etb2-1uz4A:
undetectable		 1etb2-1uz4A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		4 LEU A 189
GLU A 178
THR A   9
LEU A  16
 None
 1.27A 1etb2-1v5xA:
undetectable		 1etb2-1v5xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		4 LEU A 125
GLU A  91
THR A  72
LEU A  76
 None
 1.27A 1etb2-1vh0A:
undetectable		 1etb2-1vh0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 166
THR A 260
ALA A 168
LEU A 189
 None
NAD  A 600 (-4.4A)
NAD  A 600 ( 4.3A)
None
 0.95A 1etb2-1x87A:
undetectable		 1etb2-1x87A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z23 CRK-ASSOCIATED
SUBSTRATE

(Rattus
norvegicus) 		PF08824
(Serine_rich) 		4 LEU A 695
THR A 560
ALA A 557
LEU A 702
 None
 1.23A 1etb2-1z23A:
undetectable		 1etb2-1z23A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		4 LEU A 231
GLU A 227
ALA A 167
LEU A 163
 None
 1.23A 1etb2-1zc6A:
undetectable		 1etb2-1zc6A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		4 LEU A 231
GLU A 227
THR A 185
LEU A 163
 None
 1.02A 1etb2-1zc6A:
undetectable		 1etb2-1zc6A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLU A 573
THR A 565
ALA A 563
LEU A 461
 None
 1.17A 1etb2-2b3xA:
undetectable		 1etb2-2b3xA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 LEU A 193
GLU A 218
THR A 237
LEU A 241
 None
 0.80A 1etb2-2cb0A:
undetectable		 1etb2-2cb0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7b OBSCURIN

(Homo sapiens) 		PF07679
(I-set) 		4 LEU A  18
THR A  87
ALA A  89
LEU A  91
 None
 0.87A 1etb2-2e7bA:
undetectable		 1etb2-2e7bA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF13192
(Thioredoxin_3) 		4 GLU A 178
THR A  89
ALA A  91
LEU A  93
 None
 0.94A 1etb2-2hlsA:
undetectable		 1etb2-2hlsA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 333
THR A  94
ALA A  90
LEU A  86
 None
 1.20A 1etb2-2hneA:
undetectable		 1etb2-2hneA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5c PLECKSTRIN

(Homo sapiens) 		PF00169
(PH) 		4 GLU A 337
THR A 331
ALA A 329
LEU A 327
 None
 0.92A 1etb2-2i5cA:
undetectable		 1etb2-2i5cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 LEU A 300
THR A 289
ALA A 293
LEU A 297
 None
 1.12A 1etb2-2i7xA:
undetectable		 1etb2-2i7xA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 LEU A 135
GLU A 313
ALA A 167
LEU A 171
 None
 1.17A 1etb2-2j3hA:
undetectable		 1etb2-2j3hA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9z UNCHARACTERIZED
PROTEIN TM1112

(Thermotoga
maritima) 		PF05899
(Cupin_3) 		4 LYS A  77
LEU A  79
GLU A  30
THR A  51
 None
 1.16A 1etb2-2k9zA:
undetectable		 1etb2-2k9zA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lmc BACTERIAL RNA
POLYMERASE INHIBITOR

(Escherichia
virus T7) 		PF16857
(RNA_pol_inhib) 		4 GLU A  61
THR A  55
ALA A  53
LEU A  29
 None
 1.20A 1etb2-2lmcA:
undetectable		 1etb2-2lmcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1h GLUCOSIDASE 2
SUBUNIT BETA

(Schizosaccharomyces
pombe) 		PF13015
(PRKCSH_1) 		4 LYS A 375
GLU A 364
THR A 373
LEU A 388
 None
 1.26A 1etb2-2n1hA:
undetectable		 1etb2-2n1hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdl CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN

(Caldanaerobacter
subterraneus) 		PF01584
(CheW) 		4 LEU A 141
GLU A  87
ALA A  93
LEU A 144
 None
 1.22A 1etb2-2qdlA:
undetectable		 1etb2-2qdlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 LEU A 208
THR A 142
ALA A 138
LEU A 134
 None
HEM  A 502 (-3.8A)
None
None
 1.13A 1etb2-2qjpA:
undetectable		 1etb2-2qjpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnl UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF12867
(DinB_2) 		4 LEU A 159
GLU A  38
ALA A  36
LEU A  30
 CL  A 163 (-3.9A)
None
None
None
 1.21A 1etb2-2qnlA:
undetectable		 1etb2-2qnlA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LEU A 171
THR A 265
ALA A 173
LEU A 194
 None
NAD  A3001 (-4.2A)
NAD  A3001 ( 4.4A)
None
 0.94A 1etb2-2v7gA:
1.6		 1etb2-2v7gA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU B 363
THR B 415
ALA B 391
LEU B 367
 None
 0.83A 1etb2-2v9tB:
undetectable		 1etb2-2v9tB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE

(Cellvibrio
japonicus) 		PF00657
(Lipase_GDSL) 		4 LYS A 213
LEU A 218
THR A 209
LEU A 215
 None
None
GOL  A1363 (-3.6A)
None
 1.16A 1etb2-2w9xA:
undetectable		 1etb2-2w9xA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 LEU A 101
GLU A 103
THR A  82
LEU A  69
 None
 1.17A 1etb2-2ww8A:
6.9		 1etb2-2ww8A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		4 LEU A 801
GLU A 803
THR A 783
LEU A 758
 None
 1.14A 1etb2-2ww8A:
6.9		 1etb2-2ww8A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5e PROTEASOME
ASSEMBLING CHAPERONE
3

(Homo sapiens) 		PF10178
(PAC3) 		4 LYS A  65
LEU A  67
THR A  63
LEU A  45
 None
 1.07A 1etb2-2z5eA:
undetectable		 1etb2-2z5eA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 LEU A 208
GLU A 199
THR A 231
ALA A 235
 None
 1.20A 1etb2-3abzA:
undetectable		 1etb2-3abzA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra PROTEIN
FARNESYLTRANSFERASE/
GERANYLGERANYLTRANSF
ERASE TYPE-1 SUBUNIT
ALPHA

(Candida
albicans) 		PF01239
(PPTA) 		4 LEU A 166
GLU A 204
THR A 198
LEU A 189
 None
 1.13A 1etb2-3draA:
undetectable		 1etb2-3draA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 LEU A 446
THR A 440
ALA A 436
LEU A 432
 None
 1.21A 1etb2-3fahA:
undetectable		 1etb2-3fahA:
10.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		6 LYS A  15
LEU A  17
GLU A  54
THR A 106
ALA A 108
LEU A 110
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
 0.67A 1etb2-3fc8A:
22.3		 1etb2-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 287
THR A 103
ALA A 278
LEU A 273
 None
 1.26A 1etb2-3fcpA:
undetectable		 1etb2-3fcpA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 GLU A 255
THR A 226
ALA A 224
LEU A 222
 None
 1.24A 1etb2-3j08A:
undetectable		 1etb2-3j08A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		4 GLU A 255
THR A 226
ALA A 224
LEU A 222
 None
 1.26A 1etb2-3j09A:
undetectable		 1etb2-3j09A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd8 NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF02460
(Patched)
PF12349
(Sterol-sensing)
PF16414
(NPC1_N) 		4 LEU A 728
GLU A 688
THR A 759
ALA A 756
 None
 1.22A 1etb2-3jd8A:
undetectable		 1etb2-3jd8A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 LEU A 472
GLU A 519
ALA A 517
LEU A 469
 None
 1.27A 1etb2-3k7dA:
undetectable		 1etb2-3k7dA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 LEU A 570
GLU A 537
THR A 566
LEU A 525
 None
 1.28A 1etb2-3koyA:
undetectable		 1etb2-3koyA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l43 DYNAMIN-3

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU A 122
GLU A 100
THR A 105
LEU A  71
 None
 1.16A 1etb2-3l43A:
undetectable		 1etb2-3l43A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0e TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00158
(Sigma54_activat) 		4 LYS A 250
GLU A 205
ALA A 249
LEU A 245
 None
 1.26A 1etb2-3m0eA:
undetectable		 1etb2-3m0eA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgd PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		4 GLU A  53
THR A  88
ALA A  69
LEU A  50
 None
 1.17A 1etb2-3mgdA:
undetectable		 1etb2-3mgdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(marine
actinobacterium
PHSC20C1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 320
THR A 127
ALA A 123
LEU A 119
 None
 1.26A 1etb2-3msyA:
undetectable		 1etb2-3msyA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Shewanella
loihica) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LYS A   3
LEU A   5
GLU A  28
LEU A 109
 None
 1.17A 1etb2-3ntdA:
undetectable		 1etb2-3ntdA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LYS A 138
LEU A 140
GLU A 150
LEU A 126
 None
 1.19A 1etb2-3okyA:
undetectable		 1etb2-3okyA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		4 LEU A  95
THR A  56
ALA A  61
LEU A 116
 None
CL  A 316 ( 4.2A)
None
None
 1.26A 1etb2-3qatA:
undetectable		 1etb2-3qatA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		4 LEU A 426
GLU A 364
THR A 390
LEU A 429
 None
 1.24A 1etb2-3r38A:
undetectable		 1etb2-3r38A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rft URONATE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 LYS A 140
LEU A  91
THR A 114
LEU A 146
 None
 1.13A 1etb2-3rftA:
undetectable		 1etb2-3rftA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqf HPR(SER) KINASE

(Coxiella
burnetii) 		PF07475
(Hpr_kinase_C) 		4 LYS A 141
LEU A 143
GLU A 132
LEU A 128
 None
 0.95A 1etb2-3tqfA:
undetectable		 1etb2-3tqfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1

(Actinomyces
oris) 		no annotation 4 GLU A 145
THR A 123
ALA A 129
LEU A  48
 None
 0.89A 1etb2-3uxfA:
6.5		 1etb2-3uxfA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 LEU A  68
THR A 306
ALA A 310
LEU A  71
 None
 1.27A 1etb2-4aysA:
undetectable		 1etb2-4aysA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 LEU A 258
THR A 187
ALA A 183
LEU A 179
 None
 1.28A 1etb2-4c9mA:
undetectable		 1etb2-4c9mA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		4 LEU A 175
THR A 181
ALA A 179
LEU A 221
 None
 1.13A 1etb2-4co6A:
undetectable		 1etb2-4co6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU K 371
GLU K 408
ALA K 366
LEU K 368
 None
 1.17A 1etb2-4cr4K:
undetectable		 1etb2-4cr4K:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Mus musculus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A 339
GLU A 341
ALA A 337
LEU A 335
 None
 1.13A 1etb2-4dklA:
undetectable		 1etb2-4dklA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLU A  50
THR A  64
ALA A  67
LEU A 106
 None
 1.06A 1etb2-4ewjA:
undetectable		 1etb2-4ewjA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0m PROTEIN ARGONAUTE 2

(Arabidopsis
thaliana) 		PF02171
(Piwi) 		4 GLU A 600
THR A 698
ALA A 670
LEU A 594
 SO4  A 806 (-3.6A)
None
None
None
 1.05A 1etb2-4g0mA:
undetectable		 1etb2-4g0mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 LEU A 102
GLU A 180
THR A 143
ALA A 146
 PGE  A 302 ( 3.7A)
1GP  A 301 (-2.1A)
None
None
 1.27A 1etb2-4jejA:
undetectable		 1etb2-4jejA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg1 PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D

(Homo sapiens) 		PF10294
(Methyltransf_16) 		4 LYS A 125
LEU A  97
GLU A 128
THR A 158
 UNX  A 306 (-4.2A)
SAM  A 301 (-4.4A)
None
None
 1.13A 1etb2-4lg1A:
undetectable		 1etb2-4lg1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 173
THR A 207
ALA A 176
LEU A 172
 None
 1.25A 1etb2-4nf2A:
undetectable		 1etb2-4nf2A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo0 MAF-LIKE PROTEIN
BCAL2394

(Burkholderia
cenocepacia) 		PF02545
(Maf) 		4 LEU A 207
THR A  69
ALA A 132
LEU A 141
 None
 1.19A 1etb2-4oo0A:
undetectable		 1etb2-4oo0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 GLU A 339
THR A 677
ALA A 609
LEU A 611
 None
 0.89A 1etb2-4qmeA:
undetectable		 1etb2-4qmeA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42

(Desulfurococcus
amylolyticus) 		PF05343
(Peptidase_M42) 		4 LYS A 348
LEU A 345
GLU A 352
ALA A 195
 None
 1.23A 1etb2-4wwvA:
undetectable		 1etb2-4wwvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Plasmodium
falciparum) 		PF01353
(GFP)
PF02861
(Clp_N) 		4 LEU A 193
GLU A 181
THR A 267
LEU A 191
 CRO  A 215 ( 4.8A)
None
None
CRO  A 215 ( 4.9A)
 1.15A 1etb2-4xbiA:
undetectable		 1etb2-4xbiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vibrio
parahaemolyticus;
synthetic
construct) 		PF01353
(GFP) 		4 LEU A  44
GLU A  32
THR A 118
LEU A  42
 CRO  A  66 ( 4.4A)
None
None
CRO  A  66 ( 4.7A)
 1.19A 1etb2-4xgyA:
0.7		 1etb2-4xgyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE

(Acinetobacter
baumannii) 		PF01208
(URO-D) 		4 LEU A 292
THR A  21
ALA A 326
LEU A 328
 None
 0.91A 1etb2-4zr8A:
undetectable		 1etb2-4zr8A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv9 UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF01738
(DLH) 		4 LYS A  90
LEU A  88
THR A  98
LEU A 129
 None
 1.08A 1etb2-4zv9A:
undetectable		 1etb2-4zv9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 GLU A 804
THR A 808
ALA A 860
LEU A 858
 GOL  A2163 (-3.5A)
None
None
None
 0.96A 1etb2-5aorA:
undetectable		 1etb2-5aorA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apm VP1
VP3

(Parechovirus A) 		no annotation 4 LEU A 119
GLU A 155
THR B  37
ALA B  41
 None
 1.21A 1etb2-5apmA:
undetectable		 1etb2-5apmA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjp O-SUCCINYLBENZOATE
SYNTHASE

(Amycolatopsis
sp.) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 103
THR A  38
ALA A  36
LEU A  34
 None
 1.18A 1etb2-5fjpA:
undetectable		 1etb2-5fjpA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibo OPLOPHORUS-LUCIFERIN
2-MONOOXYGENASE
CATALYTIC SUBUNIT

(Oplophorus
gracilirostris) 		no annotation 4 LEU A 150
GLU A 140
THR A 159
LEU A 163
 None
 0.88A 1etb2-5iboA:
undetectable		 1etb2-5iboA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldw NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL

(Bos taurus) 		PF01058
(Oxidored_q6) 		4 LYS B  27
GLU B  27
ALA B  31
LEU B  33
 None
 1.24A 1etb2-5ldwB:
undetectable		 1etb2-5ldwB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lt9 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTB

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 GLU A  89
THR A 114
ALA A 111
LEU A 102
 None
None
ARG  A 301 (-3.3A)
None
 1.02A 1etb2-5lt9A:
undetectable		 1etb2-5lt9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2y TSSK C

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		4 LEU A 334
GLU A 331
ALA A 421
LEU A 419
 None
 1.07A 1etb2-5m2yA:
undetectable		 1etb2-5m2yA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 0.94A 1etb2-5mfbA:
undetectable		 1etb2-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 4 LEU A  44
GLU A  32
THR A 118
LEU A  42
 CRO  A  66 ( 4.8A)
None
None
None
 1.24A 1etb2-5mseA:
undetectable		 1etb2-5mseA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2585
THR A2604
ALA A2608
LEU A2612
 None
 1.27A 1etb2-5nugA:
undetectable		 1etb2-5nugA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 LYS A 180
LEU A 182
GLU A 213
LEU A 156
 None
 0.67A 1etb2-5ujsA:
undetectable		 1etb2-5ujsA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Clostridium
beijerinckii) 		PF13407
(Peripla_BP_4) 		4 LEU X 181
THR X 188
ALA X 184
LEU X 207
 None
 1.17A 1etb2-5xsjX:
undetectable		 1etb2-5xsjX:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 4 GLU A 250
THR A  90
ALA A  87
LEU A  84
 None
 1.08A 1etb2-5y50A:
undetectable		 1etb2-5y50A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 4 GLU A 335
THR A 117
ALA A 115
LEU A 111
 None
 1.06A 1etb2-6blgA:
undetectable		 1etb2-6blgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE

(Legionella
pneumophila) 		no annotation 4 LEU A 316
GLU A  15
THR A 331
LEU A 407
 None
 1.27A 1etb2-6bs7A:
undetectable		 1etb2-6bs7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 LEU A 934
GLU A 916
THR A 941
ALA A 937
 None
 1.24A 1etb2-6bv2A:
undetectable		 1etb2-6bv2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 4 LEU A  67
GLU A  30
THR A 153
LEU A 149
 None
 1.18A 1etb2-6evgA:
undetectable		 1etb2-6evgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 LEU A 967
THR A 100
ALA A 964
LEU A 962
 None
 1.18A 1etb2-6fn1A:
undetectable		 1etb2-6fn1A:
19.66