SIMILAR PATTERNS OF AMINO ACIDS FOR 1ETB_1_T441128_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpb DIHYDROLIPOYL-TRANSA
CETYLASE

(Azotobacter
vinelandii) 		PF00198
(2-oxoacid_dh) 		4 LEU A 545
GLU A 535
ALA A 537
LEU A 514
 None
 1.12A 1etb1-1dpbA:
0.0		 1etb1-1dpbA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		4 LYS A  81
LEU A  78
ALA A  80
LEU A  75
 None
 1.02A 1etb1-1eb3A:
undetectable		 1etb1-1eb3A:
15.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
 None
 0.61A 1etb1-1gkeA:
22.5		 1etb1-1gkeA:
82.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5g TRYPAREDOXIN II

(Crithidia
fasciculata) 		PF13905
(Thioredoxin_8) 		4 LEU A   4
GLU A 117
ALA A  28
LEU A  24
 None
 1.16A 1etb1-1i5gA:
0.0		 1etb1-1i5gA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		4 LEU A  59
GLU A 111
ALA A 107
LEU A 105
 None
 1.12A 1etb1-1iuhA:
undetectable		 1etb1-1iuhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		4 MET A  75
LEU A 102
GLU A  73
LEU A  49
 None
 0.99A 1etb1-1k4nA:
0.0		 1etb1-1k4nA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n07 PUTATIVE RIBOFLAVIN
KINASE

(Schizosaccharomyces
pombe) 		PF01687
(Flavokinase) 		4 LYS A 131
LEU A 124
GLU A 134
ALA A 127
 None
FMN  A 165 (-4.0A)
None
None
 1.12A 1etb1-1n07A:
0.0		 1etb1-1n07A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT

(Methanothermobacter
thermautotrophicus) 		PF01873
(eIF-5_eIF-2B) 		4 LYS A 122
GLU A 124
ALA A 130
LEU A 132
 None
 1.16A 1etb1-1neeA:
undetectable		 1etb1-1neeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT

(Klebsiella
pneumoniae) 		PF03830
(PTSIIB_sorb) 		4 MET A  56
LEU A  48
ALA A  51
LEU A  47
 None
 1.07A 1etb1-1nrzA:
0.0		 1etb1-1nrzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 MET Q 249
LEU Q 292
ALA Q 290
LEU Q 311
 None
 1.03A 1etb1-1oh2Q:
undetectable		 1etb1-1oh2Q:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LYS A 500
LEU A 497
GLU A 461
LEU A 494
 None
 1.16A 1etb1-1qlbA:
undetectable		 1etb1-1qlbA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj8 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		4 LEU A 598
GLU A 601
ALA A 596
LEU A 608
 None
 1.19A 1etb1-1sj8A:
undetectable		 1etb1-1sj8A:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		6 MET A  13
LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
 None
 0.42A 1etb1-1sn2A:
20.5		 1etb1-1sn2A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 LEU A 222
GLU A 220
ALA A 216
LEU A 116
 None
 1.04A 1etb1-1sv6A:
1.4		 1etb1-1sv6A:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		6 MET A  13
LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
 None
 0.50A 1etb1-1tfpA:
19.5		 1etb1-1tfpA:
73.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 MET A 341
LEU A 128
ALA A 131
LEU A 129
 None
 1.16A 1etb1-1tj7A:
undetectable		 1etb1-1tj7A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlf LAC REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 LEU A 184
GLU A 217
ALA A 245
LEU A 243
 None
 1.08A 1etb1-1tlfA:
undetectable		 1etb1-1tlfA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LYS A 324
LEU A 285
GLU A 327
ALA A 323
 None
 0.95A 1etb1-1ufaA:
undetectable		 1etb1-1ufaA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF05362
(Lon_C) 		4 LYS A 514
GLU A 518
ALA A 510
LEU A 507
 None
 1.12A 1etb1-1xhkA:
undetectable		 1etb1-1xhkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 LEU A 166
GLU A 160
ALA A  89
LEU A  87
 None
None
HEC  A 802 ( 3.9A)
None
 1.15A 1etb1-1zzhA:
undetectable		 1etb1-1zzhA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap9 ACETYLGLUTAMATE
KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		4 LYS A 292
GLU A 233
ALA A 268
LEU A 212
 None
 1.17A 1etb1-2ap9A:
undetectable		 1etb1-2ap9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 280
GLU A 276
ALA A 278
LEU A 281
 None
 1.03A 1etb1-2awaA:
undetectable		 1etb1-2awaA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 LEU A 182
GLU A 252
ALA A 204
LEU A 202
 None
 1.16A 1etb1-2axqA:
undetectable		 1etb1-2axqA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9u CHROMOBOX PROTEIN
HOMOLOG 2 (ISOFORM
2)

(Homo sapiens) 		PF00385
(Chromo) 		4 LEU A  53
GLU A  14
ALA A  56
LEU A  54
 None
 1.18A 1etb1-2d9uA:
undetectable		 1etb1-2d9uA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz5 FLAVODOXIN

(Megasphaera
elsdenii) 		PF00258
(Flavodoxin_1) 		4 MET A   1
LEU A  52
GLU A   3
LEU A  85
 None
 1.13A 1etb1-2fz5A:
undetectable		 1etb1-2fz5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		4 LYS A 373
LEU A 179
GLU A 361
ALA A 374
 None
 1.18A 1etb1-2h9fA:
undetectable		 1etb1-2h9fA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ikd PROPHENOLOXIDASE
ACTIVATING
PROTEINASE-2

(Manduca sexta) 		PF12032
(CLIP) 		4 LEU A  49
GLU A  51
ALA A  53
LEU A  26
 None
 1.14A 1etb1-2ikdA:
undetectable		 1etb1-2ikdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2c RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05495
(zf-CHY) 		4 LYS A  30
LEU A  37
GLU A  59
ALA A  31
 None
None
None
ZN  A 138 (-4.0A)
 1.15A 1etb1-2k2cA:
undetectable		 1etb1-2k2cA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		4 LYS A 205
LEU A 202
ALA A 204
LEU A 211
 EDO  A 298 (-2.7A)
EDO  A 298 (-4.9A)
None
None
 1.04A 1etb1-2qhpA:
undetectable		 1etb1-2qhpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 MET A 254
LEU A 290
GLU A 256
LEU A 293
 None
 1.11A 1etb1-2vw8A:
undetectable		 1etb1-2vw8A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8m ORF D212

(Sulfolobus
spindle-shaped
virus 8) 		PF12187
(VirArc_Nuclease) 		4 LEU A 157
GLU A 125
ALA A 127
LEU A 154
 None
 1.19A 1etb1-2w8mA:
undetectable		 1etb1-2w8mA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 LYS A 146
GLU A 149
ALA A 143
LEU A 119
 None
 1.09A 1etb1-2zzrA:
undetectable		 1etb1-2zzrA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		4 MET A 133
LEU A 125
ALA A 128
LEU A 164
 L2P  A 295 (-4.2A)
None
None
None
 0.99A 1etb1-3a7kA:
undetectable		 1etb1-3a7kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 LYS A 319
LEU A 340
GLU A 322
ALA A 315
 None
 1.00A 1etb1-3cb5A:
undetectable		 1etb1-3cb5A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		4 LEU A  88
GLU A 141
ALA A 144
LEU A  91
 None
 1.07A 1etb1-3e59A:
undetectable		 1etb1-3e59A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		4 MET A 218
GLU A  65
ALA A 220
LEU A 222
 None
 1.05A 1etb1-3ec4A:
undetectable		 1etb1-3ec4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6m 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF02542
(YgbB) 		4 MET A   1
LEU A  50
ALA A  53
LEU A  51
 None
 1.18A 1etb1-3f6mA:
undetectable		 1etb1-3f6mA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 LYS A  15
LEU A  17
GLU A  54
ALA A 108
LEU A 110
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
None
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
 0.72A 1etb1-3fc8A:
23.3		 1etb1-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER

(Methanosarcina
acetivorans) 		no annotation 4 MET A 651
GLU A 636
ALA A 748
LEU A 616
 None
 1.18A 1etb1-3g40A:
undetectable		 1etb1-3g40A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		4 LEU A 163
GLU A 189
ALA A 251
LEU A 194
 None
 0.99A 1etb1-3h2bA:
undetectable		 1etb1-3h2bA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		4 LEU A 352
GLU A 197
ALA A 205
LEU A 353
 None
 1.12A 1etb1-3i4jA:
undetectable		 1etb1-3i4jA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i91 CHROMOBOX PROTEIN
HOMOLOG 8

(Homo sapiens) 		PF00385
(Chromo) 		4 LEU A  53
GLU A  14
ALA A  56
LEU A  54
 None
 1.07A 1etb1-3i91A:
undetectable		 1etb1-3i91A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 LEU A 330
GLU A 269
ALA A 282
LEU A 278
 None
 1.11A 1etb1-3ifsA:
undetectable		 1etb1-3ifsA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		4 LEU D  53
GLU D  62
ALA D  38
LEU D  42
 None
 1.03A 1etb1-3k70D:
undetectable		 1etb1-3k70D:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 LYS A 223
GLU A 178
ALA A 261
LEU A  12
 2FP  A 350 (-2.2A)
2FP  A 350 (-2.6A)
None
None
 1.10A 1etb1-3mmtA:
undetectable		 1etb1-3mmtA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Shewanella
loihica) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LYS A   3
LEU A   5
GLU A  28
LEU A 109
 None
 1.18A 1etb1-3ntdA:
undetectable		 1etb1-3ntdA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 LEU A 321
GLU A 303
ALA A 285
LEU A 283
 None
 1.02A 1etb1-3oepA:
undetectable		 1etb1-3oepA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LYS A 138
LEU A 140
GLU A 150
LEU A 126
 None
 1.17A 1etb1-3okyA:
undetectable		 1etb1-3okyA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on1 BH2414 PROTEIN

(Bacillus
halodurans) 		PF01248
(Ribosomal_L7Ae) 		4 LYS A   3
LEU A   7
GLU A   3
LEU A  10
 None
 1.16A 1etb1-3on1A:
undetectable		 1etb1-3on1A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		4 LEU A  51
GLU A  60
ALA A  19
LEU A  64
 None
SO4  A 262 (-3.1A)
None
None
 1.14A 1etb1-3ozbA:
undetectable		 1etb1-3ozbA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		4 LEU A 235
GLU A 242
ALA A 237
LEU A 233
 None
 1.18A 1etb1-3rc3A:
undetectable		 1etb1-3rc3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqf HPR(SER) KINASE

(Coxiella
burnetii) 		PF07475
(Hpr_kinase_C) 		4 LYS A 141
LEU A 143
GLU A 132
LEU A 128
 None
 0.96A 1etb1-3tqfA:
undetectable		 1etb1-3tqfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		4 MET A 207
LEU A 223
ALA A 221
LEU A 219
 None
 1.10A 1etb1-3wo8A:
undetectable		 1etb1-3wo8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A 299
GLU A 297
ALA A 301
LEU A 303
 None
 1.18A 1etb1-4a0kA:
undetectable		 1etb1-4a0kA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  94
LEU A  99
GLU A  93
LEU A 100
 None
 1.15A 1etb1-4bgqA:
undetectable		 1etb1-4bgqA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU K 371
GLU K 408
ALA K 366
LEU K 368
 None
 1.19A 1etb1-4cr4K:
undetectable		 1etb1-4cr4K:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Mus musculus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A 339
GLU A 341
ALA A 337
LEU A 335
 None
 1.09A 1etb1-4dklA:
undetectable		 1etb1-4dklA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 LEU A 144
GLU A  73
ALA A 126
LEU A 141
 None
 1.08A 1etb1-4fyeA:
undetectable		 1etb1-4fyeA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 MET C 221
LYS C 219
ALA C 233
LEU C 235
 None
 0.86A 1etb1-4g59C:
undetectable		 1etb1-4g59C:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 LYS A  45
LEU A 321
GLU A 317
ALA A  46
 None
 1.14A 1etb1-4i2yA:
undetectable		 1etb1-4i2yA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw3 NS1

(Human bocavirus) 		no annotation 4 LEU A  33
GLU A 159
ALA A  36
LEU A  34
 None
 1.15A 1etb1-4kw3A:
undetectable		 1etb1-4kw3A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 MET A 268
LEU A 217
GLU A 266
LEU A 218
 None
 1.03A 1etb1-4lixA:
undetectable		 1etb1-4lixA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhu H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, L-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I) 		4 LEU E 160
GLU E 163
ALA E 158
LEU E 130
 None
 1.08A 1etb1-4nhuE:
undetectable		 1etb1-4nhuE:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		4 LEU A 238
GLU A 247
ALA A 249
LEU A 235
 None
 1.13A 1etb1-4o48A:
undetectable		 1etb1-4o48A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		4 LEU A 110
GLU A 154
ALA A   6
LEU A   4
 None
None
NAP  A 202 ( 4.2A)
None
 1.16A 1etb1-4p68A:
undetectable		 1etb1-4p68A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LYS A 386
LEU A 444
GLU A 385
ALA A 382
 None
 1.13A 1etb1-4pj6A:
undetectable		 1etb1-4pj6A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 LEU A 301
GLU A 141
ALA A 299
LEU A 313
 None
 1.02A 1etb1-4r0vA:
undetectable		 1etb1-4r0vA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 LEU A  31
GLU A  37
ALA A 254
LEU A 275
 None
 1.15A 1etb1-4v15A:
undetectable		 1etb1-4v15A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 1.03A 1etb1-4v3qA:
undetectable		 1etb1-4v3qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xco SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,SIGNAL
SEQUENCE

(Methanocaldococcus
jannaschii) 		PF02978
(SRP_SPB) 		4 LEU C 471
GLU C 361
ALA C 474
LEU C 470
 None
 1.13A 1etb1-4xcoC:
undetectable		 1etb1-4xcoC:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.03A 1etb1-4xvxA:
undetectable		 1etb1-4xvxA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 LEU A 201
GLU A 199
ALA A  40
LEU A  38
 None
 1.11A 1etb1-4zhjA:
undetectable		 1etb1-4zhjA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a21 PORTAL PROTEIN

(Bacillus phage
SPP1) 		PF05133
(Phage_prot_Gp6) 		4 LEU A 181
GLU A 163
ALA A 197
LEU A 199
 None
 1.18A 1etb1-5a21A:
undetectable		 1etb1-5a21A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		4 LEU O 307
GLU O 326
ALA O 320
LEU O 310
 None
 0.96A 1etb1-5a31O:
undetectable		 1etb1-5a31O:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 MET L 499
LEU L 587
ALA L 541
LEU L 539
 None
 0.74A 1etb1-5a7dL:
undetectable		 1etb1-5a7dL:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5r GASDERMIN-A3

(Mus musculus) 		PF04598
(Gasdermin) 		4 LEU A 447
GLU A 277
ALA A 443
LEU A 448
 None
 1.05A 1etb1-5b5rA:
undetectable		 1etb1-5b5rA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8f 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02542
(YgbB) 		4 MET A   1
LEU A  48
ALA A  51
LEU A  49
 None
 1.17A 1etb1-5b8fA:
undetectable		 1etb1-5b8fA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv0 VPS16

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		4 LYS B 551
GLU B 554
ALA B 548
LEU B 538
 None
 1.07A 1etb1-5bv0B:
undetectable		 1etb1-5bv0B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 MET A 207
LEU A 223
ALA A 221
LEU A 219
 None
 1.09A 1etb1-5bzaA:
undetectable		 1etb1-5bzaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A 322
GLU A 324
ALA A 320
LEU A 318
 None
 1.03A 1etb1-5dhgA:
undetectable		 1etb1-5dhgA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 4 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 1.03A 1etb1-5ec0A:
undetectable		 1etb1-5ec0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 LYS A 338
GLU A 342
ALA A 332
LEU A 334
 None
 1.16A 1etb1-5fyqA:
undetectable		 1etb1-5fyqA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsb H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, K-D ALPHA
CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU A 160
GLU A 163
ALA A 158
LEU A 130
 None
 1.16A 1etb1-5gsbA:
undetectable		 1etb1-5gsbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 4 LYS A1031
GLU A1033
ALA A1030
LEU A1028
 None
 1.13A 1etb1-5hdtA:
undetectable		 1etb1-5hdtA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		4 LYS A 340
GLU A 339
ALA A 342
LEU A 310
 None
 1.15A 1etb1-5intA:
undetectable		 1etb1-5intA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 MET A 274
LYS A 276
LEU A 290
LEU A 343
 None
SO4  A 600 (-3.1A)
None
None
 1.15A 1etb1-5jm7A:
undetectable		 1etb1-5jm7A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2y TSSK C

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		4 LEU A 334
GLU A 331
ALA A 421
LEU A 419
 None
 1.04A 1etb1-5m2yA:
undetectable		 1etb1-5m2yA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A  55
GLU A  93
ALA A  96
LEU A  58
 None
 0.93A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A  97
GLU A 135
ALA A 138
LEU A 100
 None
 0.88A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.93A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 181
GLU A 219
ALA A 222
LEU A 184
 None
 0.91A 1etb1-5mfbA:
undetectable		 1etb1-5mfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfd YIIIM''6AII

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 265
GLU A 303
ALA A 306
LEU A 268
 None
 0.88A 1etb1-5mfdA:
undetectable		 1etb1-5mfdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfo YIIIM3AIII

(synthetic
construct) 		PF00514
(Arm) 		4 LEU A 139
GLU A 177
ALA A 180
LEU A 142
 None
 0.86A 1etb1-5mfoA:
undetectable		 1etb1-5mfoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4w CULLIN-2

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A  53
GLU A  51
ALA A  48
LEU A  45
 None
 0.96A 1etb1-5n4wA:
undetectable		 1etb1-5n4wA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 LYS A 180
LEU A 182
GLU A 213
LEU A 156
 None
 0.66A 1etb1-5ujsA:
undetectable		 1etb1-5ujsA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1

(Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1) 		4 LEU A 300
GLU A 332
ALA A 327
LEU A 325
 None
 1.11A 1etb1-5uz9A:
undetectable		 1etb1-5uz9A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlg T CELL RECEPTOR
ALPHA VARIABLE
8D-2,HUMAN NKT TCR
ALPHA CHAIN CHIMERA

(Homo sapiens;
Mus musculus) 		no annotation 4 LYS D  55
GLU D  52
ALA D  62
LEU D  60
 None
 1.19A 1etb1-5wlgD:
undetectable		 1etb1-5wlgD:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 MET O1294
LEU O1099
GLU O1293
LEU O1096
 None
 0.99A 1etb1-5x0yO:
undetectable		 1etb1-5x0yO:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 LEU A 672
GLU A 724
ALA A 717
LEU A 675
 None
 1.12A 1etb1-5xqoA:
undetectable		 1etb1-5xqoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 MET A 459
LYS A 456
ALA A 454
LEU A 447
 None
 1.16A 1etb1-6es9A:
undetectable		 1etb1-6es9A:
19.69