SIMILAR PATTERNS OF AMINO ACIDS FOR 1ETA_1_T441128_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dpb | DIHYDROLIPOYL-TRANSACETYLASE (Azotobactervinelandii) |
PF00198(2-oxoacid_dh) | 4 | LEU A 545GLU A 535ALA A 537LEU A 514 | None | 1.15A | 1eta1-1dpbA:0.0 | 1eta1-1dpbA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fp3 | N-ACYL-D-GLUCOSAMINE2-EPIMERASE (Sus scrofa) |
PF07221(GlcNAc_2-epim) | 4 | LEU A 335GLU A 329ALA A 322LEU A 338 | None | 0.96A | 1eta1-1fp3A:undetectable | 1eta1-1fp3A:16.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gke | TRANSTHYRETIN (Rattusnorvegicus) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17GLU A 54ALA A 108LEU A 110 | None | 0.61A | 1eta1-1gkeA:21.7 | 1eta1-1gkeA:82.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5g | TRYPAREDOXIN II (Crithidiafasciculata) |
PF13905(Thioredoxin_8) | 4 | LEU A 4GLU A 117ALA A 28LEU A 24 | None | 1.20A | 1eta1-1i5gA:undetectable | 1eta1-1i5gA:25.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iuh | 2'-5' RNA LIGASE (Thermusthermophilus) |
PF02834(LigT_PEase) | 4 | LEU A 59GLU A 111ALA A 107LEU A 105 | None | 1.15A | 1eta1-1iuhA:0.0 | 1eta1-1iuhA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n07 | PUTATIVE RIBOFLAVINKINASE (Schizosaccharomycespombe) |
PF01687(Flavokinase) | 4 | LYS A 131LEU A 124GLU A 134ALA A 127 | NoneFMN A 165 (-4.0A)NoneNone | 1.10A | 1eta1-1n07A:0.0 | 1eta1-1n07A:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nee | PROBABLE TRANSLATIONINITIATION FACTOR 2BETA SUBUNIT (Methanothermobacterthermautotrophicus) |
PF01873(eIF-5_eIF-2B) | 4 | LYS A 122GLU A 124ALA A 130LEU A 132 | None | 1.19A | 1eta1-1neeA:undetectable | 1eta1-1neeA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlb | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Wolinellasuccinogenes) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | LYS A 500LEU A 497GLU A 461LEU A 494 | None | 1.16A | 1eta1-1qlbA:0.0 | 1eta1-1qlbA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sjp | 60 KDA CHAPERONIN 2 (Mycobacteriumtuberculosis) |
PF00118(Cpn60_TCP1) | 4 | LEU A 500GLU A 123ALA A 504LEU A 93 | None | 1.14A | 1eta1-1sjpA:undetectable | 1eta1-1sjpA:13.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1sn2 | TRANSTHYRETIN (Sparus aurata) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17GLU A 54ALA A 108LEU A 110 | None | 0.44A | 1eta1-1sn2A:19.8 | 1eta1-1sn2A:54.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sv6 | 2-KETO-4-PENTENOATEHYDRATASE (Escherichiacoli) |
PF01557(FAA_hydrolase) | 4 | LEU A 222GLU A 220ALA A 216LEU A 116 | None | 1.04A | 1eta1-1sv6A:1.3 | 1eta1-1sv6A:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3o | CARBON STORAGEREGULATOR (Bacillussubtilis) |
PF02599(CsrA) | 4 | LYS A 38GLU A -3ALA A 36LEU A 2 | None | 1.20A | 1eta1-1t3oA:undetectable | 1eta1-1t3oA:23.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tfp | TRANSTHYRETIN (Gallus gallus) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17GLU A 54ALA A 108LEU A 110 | None | 0.44A | 1eta1-1tfpA:18.8 | 1eta1-1tfpA:73.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufa | TT1467 PROTEIN (Thermusthermophilus) |
PF03065(Glyco_hydro_57)PF09210(DUF1957) | 4 | LYS A 324LEU A 285GLU A 327ALA A 323 | None | 0.98A | 1eta1-1ufaA:undetectable | 1eta1-1ufaA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhk | PUTATIVE PROTEASE LAHOMOLOG (Methanocaldococcusjannaschii) |
PF05362(Lon_C) | 4 | LYS A 514GLU A 518ALA A 510LEU A 507 | None | 1.10A | 1eta1-1xhkA:undetectable | 1eta1-1xhkA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xmb | IAA-AMINO ACIDHYDROLASE HOMOLOG 2 (Arabidopsisthaliana) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | LYS A 43LEU A 39ALA A 42LEU A 38 | None | 1.05A | 1eta1-1xmbA:undetectable | 1eta1-1xmbA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y79 | PEPTIDYL-DIPEPTIDASEDCP (Escherichiacoli) |
PF01432(Peptidase_M3) | 4 | LEU 1 551GLU 1 583ALA 1 554LEU 1 550 | NoneNoneNoneASP 1 704 ( 4.7A) | 1.21A | 1eta1-1y791:undetectable | 1eta1-1y791:12.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzh | CYTOCHROME CPEROXIDASE (Rhodobactercapsulatus) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 4 | LEU A 166GLU A 160ALA A 89LEU A 87 | NoneNoneHEC A 802 ( 3.9A)None | 1.12A | 1eta1-1zzhA:undetectable | 1eta1-1zzhA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ap9 | ACETYLGLUTAMATEKINASE (Mycobacteriumtuberculosis) |
PF00696(AA_kinase) | 4 | LYS A 292GLU A 233ALA A 268LEU A 212 | None | 1.20A | 1eta1-2ap9A:undetectable | 1eta1-2ap9A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2awa | DNA POLYMERASE III,BETA CHAIN (Streptococcuspneumoniae) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 4 | LEU A 280GLU A 276ALA A 278LEU A 281 | None | 1.04A | 1eta1-2awaA:undetectable | 1eta1-2awaA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gq0 | CHAPERONE PROTEINHTPG (Escherichiacoli) |
PF00183(HSP90) | 4 | LEU A 399GLU A 417ALA A 397LEU A 382 | None | 1.21A | 1eta1-2gq0A:undetectable | 1eta1-2gq0A:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ikd | PROPHENOLOXIDASEACTIVATINGPROTEINASE-2 (Manduca sexta) |
PF12032(CLIP) | 4 | LEU A 49GLU A 51ALA A 53LEU A 26 | None | 1.11A | 1eta1-2ikdA:undetectable | 1eta1-2ikdA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j28 | 50S RIBOSOMALPROTEIN L2 (Escherichiacoli) |
PF00181(Ribosomal_L2)PF03947(Ribosomal_L2_C) | 4 | LEU C 191GLU C 193ALA C 189LEU C 129 | None | 1.18A | 1eta1-2j28C:undetectable | 1eta1-2j28C:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k2c | RING FINGER AND CHYZINC FINGERDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF05495(zf-CHY) | 4 | LYS A 30LEU A 37GLU A 59ALA A 31 | NoneNoneNone ZN A 138 (-4.0A) | 1.17A | 1eta1-2k2cA:undetectable | 1eta1-2k2cA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lrs | ENDORIBONUCLEASEDICER HOMOLOG 1 (Arabidopsisthaliana) |
PF14709(DND1_DSRM) | 4 | LEU A 78GLU A 58ALA A 74LEU A 79 | None | 1.19A | 1eta1-2lrsA:undetectable | 1eta1-2lrsA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w8m | ORF D212 (Sulfolobusspindle-shapedvirus 8) |
PF12187(VirArc_Nuclease) | 4 | LEU A 157GLU A 125ALA A 127LEU A 154 | None | 1.21A | 1eta1-2w8mA:undetectable | 1eta1-2w8mA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y3a | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd)PF02192(PI3K_p85B) | 4 | LEU A 351GLU A 356ALA A 392LEU A 394 | None | 0.95A | 1eta1-2y3aA:3.0 | 1eta1-2y3aA:7.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzr | UNSATURATEDGLUCURONYL HYDROLASE (Streptococcusagalactiae) |
PF07470(Glyco_hydro_88) | 4 | LYS A 146GLU A 149ALA A 143LEU A 119 | None | 1.05A | 1eta1-2zzrA:undetectable | 1eta1-2zzrA:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abb | CYTOCHROME P450HYDROXYLASE (Streptomycesavermitilis) |
PF00067(p450) | 4 | LEU A 125GLU A 364ALA A 366LEU A 128 | None | 1.20A | 1eta1-3abbA:undetectable | 1eta1-3abbA:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cb5 | FACT COMPLEX SUBUNITSPT16 (Schizosaccharomycespombe) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 4 | LYS A 319LEU A 340GLU A 322ALA A 315 | None | 1.04A | 1eta1-3cb5A:undetectable | 1eta1-3cb5A:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnn | PUTATIVEUNCHARACTERIZEDPROTEIN (Thermotogamaritima) |
PF01926(MMR_HSR1) | 4 | LEU A 168GLU A 246ALA A 166LEU A 174 | None | 1.20A | 1eta1-3cnnA:undetectable | 1eta1-3cnnA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e59 | PYOVERDINEBIOSYNTHESIS PROTEINPVCA (Pseudomonasaeruginosa) |
PF05141(DIT1_PvcA) | 4 | LEU A 88GLU A 141ALA A 144LEU A 91 | None | 1.04A | 1eta1-3e59A:undetectable | 1eta1-3e59A:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ejv | UNCHARACTERIZEDPROTEIN WITHCYSTATIN-LIKE FOLD (Novosphingobiumaromaticivorans) |
PF13577(SnoaL_4) | 4 | LEU A 95GLU A 6ALA A 93LEU A 135 | None | 1.19A | 1eta1-3ejvA:undetectable | 1eta1-3ejvA:21.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fc8 | TRANSTHYRETIN (Homo sapiens) |
PF00576(Transthyretin) | 5 | LYS A 15LEU A 17GLU A 54ALA A 108LEU A 110 | IFA A3000 (-3.0A)IFA A3000 ( 4.7A)NoneIFA A3000 (-3.1A)IFA A3000 (-4.1A) | 0.70A | 1eta1-3fc8A:22.5 | 1eta1-3fc8A:99.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2b | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 4 | LEU A 163GLU A 189ALA A 251LEU A 194 | None | 0.98A | 1eta1-3h2bA:undetectable | 1eta1-3h2bA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i04 | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT BETA (Moorellathermoacetica) |
PF03063(Prismane) | 4 | LEU A 107GLU A 214ALA A 219LEU A 104 | None | 1.16A | 1eta1-3i04A:undetectable | 1eta1-3i04A:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4j | AMINOTRANSFERASE,CLASS III (Deinococcusradiodurans) |
PF00202(Aminotran_3) | 4 | LEU A 352GLU A 197ALA A 205LEU A 353 | None | 1.16A | 1eta1-3i4jA:undetectable | 1eta1-3i4jA:14.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i91 | CHROMOBOX PROTEINHOMOLOG 8 (Homo sapiens) |
PF00385(Chromo) | 4 | LEU A 53GLU A 14ALA A 56LEU A 54 | None | 1.05A | 1eta1-3i91A:undetectable | 1eta1-3i91A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifs | GLUCOSE-6-PHOSPHATEISOMERASE (Bacillusanthracis) |
PF00342(PGI) | 4 | LEU A 330GLU A 269ALA A 282LEU A 278 | None | 1.07A | 1eta1-3ifsA:undetectable | 1eta1-3ifsA:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV ALPHA CHAIN (Escherichiacoli) |
PF13538(UvrD_C_2)PF13604(AAA_30) | 4 | LEU D 53GLU D 62ALA D 38LEU D 42 | None | 1.02A | 1eta1-3k70D:undetectable | 1eta1-3k70D:12.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m0e | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00158(Sigma54_activat) | 4 | LEU A 251GLU A 205ALA A 249LEU A 296 | None | 1.21A | 1eta1-3m0eA:undetectable | 1eta1-3m0eA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m0e | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00158(Sigma54_activat) | 4 | LYS A 250GLU A 205ALA A 249LEU A 245 | None | 1.20A | 1eta1-3m0eA:undetectable | 1eta1-3m0eA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m16 | TRANSALDOLASE (Oleispiraantarctica) |
PF00923(TAL_FSA) | 4 | LEU A 122GLU A 103ALA A 85LEU A 125 | None | 1.16A | 1eta1-3m16A:undetectable | 1eta1-3m16A:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmt | FRUCTOSE-BISPHOSPHATE ALDOLASE (Bartonellahenselae) |
PF00274(Glycolytic) | 4 | LYS A 223GLU A 178ALA A 261LEU A 12 | 2FP A 350 (-2.2A)2FP A 350 (-2.6A)NoneNone | 1.10A | 1eta1-3mmtA:undetectable | 1eta1-3mmtA:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntd | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Shewanellaloihica) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | LYS A 3LEU A 5GLU A 28LEU A 109 | None | 1.17A | 1eta1-3ntdA:undetectable | 1eta1-3ntdA:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oep | PUTATIVEUNCHARACTERIZEDPROTEIN TTHA0988 (Thermusthermophilus) |
PF02626(CT_A_B)PF02682(CT_C_D) | 4 | LEU A 321GLU A 303ALA A 285LEU A 283 | None | 1.03A | 1eta1-3oepA:undetectable | 1eta1-3oepA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oky | PLEXIN-A2 (Mus musculus) |
PF01403(Sema)PF01437(PSI) | 4 | LYS A 138LEU A 140GLU A 150LEU A 126 | None | 1.17A | 1eta1-3okyA:undetectable | 1eta1-3okyA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on1 | BH2414 PROTEIN (Bacillushalodurans) |
PF01248(Ribosomal_L7Ae) | 4 | LYS A 3LEU A 7GLU A 3LEU A 10 | None | 1.15A | 1eta1-3on1A:undetectable | 1eta1-3on1A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqf | HPR(SER) KINASE (Coxiellaburnetii) |
PF07475(Hpr_kinase_C) | 4 | LYS A 141LEU A 143GLU A 132LEU A 128 | None | 0.98A | 1eta1-3tqfA:undetectable | 1eta1-3tqfA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttl | POLYAMINE TRANSPORTPROTEIN (Pseudomonasaeruginosa) |
PF13416(SBP_bac_8) | 4 | LEU A 190GLU A 161ALA A 186LEU A 192 | None | 1.20A | 1eta1-3ttlA:undetectable | 1eta1-3ttlA:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvo | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
PF09481(CRISPR_Cse1) | 4 | LEU A 415GLU A 373ALA A 404LEU A 474 | None | 1.21A | 1eta1-3wvoA:undetectable | 1eta1-3wvoA:12.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0k | CULLIN-4A (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 4 | LEU A 299GLU A 297ALA A 301LEU A 303 | None | 1.17A | 1eta1-4a0kA:undetectable | 1eta1-4a0kA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a22 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Mycobacteriumtuberculosis) |
PF01116(F_bP_aldolase) | 4 | LEU A 238GLU A 192ALA A 234LEU A 240 | None | 1.19A | 1eta1-4a22A:undetectable | 1eta1-4a22A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a22 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Mycobacteriumtuberculosis) |
PF01116(F_bP_aldolase) | 4 | LEU A 238GLU A 192ALA A 236LEU A 240 | None | 1.20A | 1eta1-4a22A:undetectable | 1eta1-4a22A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgq | CYCLIN-DEPENDENTKINASE-LIKE 5 (Homo sapiens) |
PF00069(Pkinase) | 4 | LYS A 94LEU A 99GLU A 93LEU A 100 | None | 1.15A | 1eta1-4bgqA:undetectable | 1eta1-4bgqA:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cr4 | 26S PROTEASEREGULATORY SUBUNIT6B HOMOLOG (Saccharomycescerevisiae) |
PF00004(AAA) | 4 | LEU K 371GLU K 408ALA K 366LEU K 368 | None | 1.20A | 1eta1-4cr4K:undetectable | 1eta1-4cr4K:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkl | MU-TYPE OPIOIDRECEPTOR, LYSOZYMECHIMERA (Escherichiavirus T4;Mus musculus) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | LEU A 339GLU A 341ALA A 337LEU A 335 | None | 1.10A | 1eta1-4dklA:undetectable | 1eta1-4dklA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fye | SIDF, INHIBITOR OFGROWTH FAMILY,MEMBER 3 (Legionellapneumophila) |
no annotation | 4 | LEU A 144GLU A 73ALA A 126LEU A 141 | None | 1.09A | 1eta1-4fyeA:undetectable | 1eta1-4fyeA:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ggv | CYTOCHROME P450SUPERFAMILY PROTEIN (Streptomyceshimastatinicus) |
PF00067(p450) | 4 | LEU A 221GLU A 219ALA A 214LEU A 211 | None | 1.06A | 1eta1-4ggvA:undetectable | 1eta1-4ggvA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i2w | PROTEIN UNC-45 (Caenorhabditiselegans) |
PF11701(UNC45-central) | 4 | LEU A 574GLU A 644ALA A 647LEU A 577 | None | 1.19A | 1eta1-4i2wA:undetectable | 1eta1-4i2wA:8.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i2y | RGECO1 (Discosoma sp.;Gallus gallus;Rattusnorvegicus) |
PF01353(GFP)PF13499(EF-hand_7) | 4 | LYS A 45LEU A 321GLU A 317ALA A 46 | None | 1.12A | 1eta1-4i2yA:undetectable | 1eta1-4i2yA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw3 | NS1 (Human bocavirus) |
no annotation | 4 | LEU A 33GLU A 159ALA A 36LEU A 34 | None | 1.13A | 1eta1-4kw3A:undetectable | 1eta1-4kw3A:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhu | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, L-D ALPHACHAIN (Mus musculus) |
PF00129(MHC_I) | 4 | LEU E 160GLU E 163ALA E 158LEU E 130 | None | 1.09A | 1eta1-4nhuE:undetectable | 1eta1-4nhuE:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 4 | LEU A 110GLU A 154ALA A 6LEU A 4 | NoneNoneNAP A 202 ( 4.2A)None | 1.17A | 1eta1-4p68A:undetectable | 1eta1-4p68A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj6 | LEUCYL-CYSTINYLAMINOPEPTIDASE (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 4 | LYS A 386LEU A 444GLU A 385ALA A 382 | None | 1.13A | 1eta1-4pj6A:undetectable | 1eta1-4pj6A:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0v | FE-HYDROGENASE (Chlamydomonasreinhardtii) |
PF02256(Fe_hyd_SSU)PF02906(Fe_hyd_lg_C) | 4 | LEU A 301GLU A 141ALA A 299LEU A 313 | None | 1.04A | 1eta1-4r0vA:undetectable | 1eta1-4r0vA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 4 | LEU A 21GLU A 46ALA A 17LEU A 22 | None | 1.18A | 1eta1-4rbnA:undetectable | 1eta1-4rbnA:11.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v15 | D-THREONINE ALDOLASE (Achromobacterxylosoxidans) |
PF01168(Ala_racemase_N)PF14031(D-ser_dehydrat) | 4 | LEU A 31GLU A 37ALA A 254LEU A 275 | None | 1.18A | 1eta1-4v15A:undetectable | 1eta1-4v15A:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v3q | YIII_M4_AII (syntheticconstruct) |
PF00514(Arm)PF16186(Arm_3) | 4 | LEU A 181GLU A 219ALA A 222LEU A 184 | None | 1.03A | 1eta1-4v3qA:undetectable | 1eta1-4v3qA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xco | SIGNAL RECOGNITIONPARTICLE 54 KDAPROTEIN,SIGNALSEQUENCE (Methanocaldococcusjannaschii) |
PF02978(SRP_SPB) | 4 | LEU C 471GLU C 361ALA C 474LEU C 470 | None | 1.08A | 1eta1-4xcoC:undetectable | 1eta1-4xcoC:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xjn | NUCLEOCAPSID (Mammalianrubulavirus 5) |
PF00973(Paramyxo_ncap) | 4 | LEU A 137GLU A 135ALA A 144LEU A 141 | None | 1.09A | 1eta1-4xjnA:undetectable | 1eta1-4xjnA:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvx | ACYL-[ACYL-CARRIER-PROTEIN]DEHYDROGENASE MBTN (Mycobacteriumtuberculosis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | LYS A 312LEU A 362ALA A 308LEU A 365 | None | 1.05A | 1eta1-4xvxA:undetectable | 1eta1-4xvxA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhj | MG-CHELATASE SUBUNITCHLH (Synechocystissp. PCC 6803) |
PF02514(CobN-Mg_chel)PF11965(DUF3479) | 4 | LEU A 201GLU A 199ALA A 40LEU A 38 | None | 1.12A | 1eta1-4zhjA:undetectable | 1eta1-4zhjA:6.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zms | RESPONSE REGULATOR (Streptococcuspneumoniae) |
PF00072(Response_reg)PF00196(GerE) | 4 | LYS A 2LEU A 30GLU A 27LEU A 4 | None | 1.20A | 1eta1-4zmsA:undetectable | 1eta1-4zmsA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a21 | PORTAL PROTEIN (Bacillus phageSPP1) |
PF05133(Phage_prot_Gp6) | 4 | LEU A 181GLU A 163ALA A 197LEU A 199 | None | 1.16A | 1eta1-5a21A:undetectable | 1eta1-5a21A:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a31 | ANAPHASE-PROMOTINGCOMPLEX SUBUNIT 5 (Homo sapiens) |
PF12862(ANAPC5) | 4 | LEU O 307GLU O 326ALA O 320LEU O 310 | None | 0.99A | 1eta1-5a31O:undetectable | 1eta1-5a31O:9.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5r | GASDERMIN-A3 (Mus musculus) |
PF04598(Gasdermin) | 4 | LEU A 447GLU A 277ALA A 443LEU A 448 | None | 1.05A | 1eta1-5b5rA:undetectable | 1eta1-5b5rA:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dhg | SOLUBLE CYTOCHROMEB562,NOCICEPTINRECEPTOR (Escherichiacoli;Homo sapiens) |
PF00001(7tm_1) | 4 | LEU A 322GLU A 324ALA A 320LEU A 318 | None | 1.04A | 1eta1-5dhgA:undetectable | 1eta1-5dhgA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dot | CARBAMOYL-PHOSPHATESYNTHASE [AMMONIA],MITOCHONDRIAL (Homo sapiens) |
PF00117(GATase)PF00988(CPSase_sm_chain)PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 4 | LYS A 182GLU A 184ALA A 68LEU A 180 | None | 1.18A | 1eta1-5dotA:undetectable | 1eta1-5dotA:7.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ec0 | ALP7A (Bacillussubtilis) |
no annotation | 4 | LYS A 158LEU A 160GLU A 167LEU A 57 | None | 1.02A | 1eta1-5ec0A:undetectable | 1eta1-5ec0A:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 4 | LYS A 338GLU A 342ALA A 332LEU A 334 | None | 1.13A | 1eta1-5fyqA:undetectable | 1eta1-5fyqA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5glj | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 13 (Homo sapiens) |
PF00595(PDZ) | 4 | LEU A1104GLU A1169ALA A1167LEU A1164 | None | 1.15A | 1eta1-5gljA:undetectable | 1eta1-5gljA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsb | H-2 CLASS IHISTOCOMPATIBILITYANTIGEN, K-D ALPHACHAIN (Mus musculus) |
PF00129(MHC_I)PF07654(C1-set) | 4 | LEU A 160GLU A 163ALA A 158LEU A 130 | None | 1.16A | 1eta1-5gsbA:undetectable | 1eta1-5gsbA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 4 | LEU A1019GLU A 931ALA A1017LEU A1020 | None | 1.18A | 1eta1-5h42A:undetectable | 1eta1-5h42A:8.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdt | SISTER CHROMATIDCOHESION PROTEINPDS5 HOMOLOG B (Homo sapiens) |
no annotation | 4 | LYS A1031GLU A1033ALA A1030LEU A1028 | None | 1.13A | 1eta1-5hdtA:undetectable | 1eta1-5hdtA:8.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5int | PHOSPHOPANTOTHENOYLCYSTEINEDECARBOXYLASE (Bacillusanthracis) |
PF04127(DFP) | 4 | LYS A 340GLU A 339ALA A 342LEU A 310 | None | 1.14A | 1eta1-5intA:undetectable | 1eta1-5intA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m2y | TSSK C (Escherichiacoli) |
PF05936(T6SS_VasE) | 4 | LEU A 334GLU A 331ALA A 421LEU A 419 | None | 1.03A | 1eta1-5m2yA:undetectable | 1eta1-5m2yA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfb | YIII(DQ)4CQI (syntheticconstruct) |
PF00514(Arm) | 4 | LEU A 55GLU A 93ALA A 96LEU A 58 | None | 0.94A | 1eta1-5mfbA:undetectable | 1eta1-5mfbA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfb | YIII(DQ)4CQI (syntheticconstruct) |
PF00514(Arm) | 4 | LEU A 97GLU A 135ALA A 138LEU A 100 | None | 0.89A | 1eta1-5mfbA:undetectable | 1eta1-5mfbA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfb | YIII(DQ)4CQI (syntheticconstruct) |
PF00514(Arm) | 4 | LEU A 139GLU A 177ALA A 180LEU A 142 | None | 0.93A | 1eta1-5mfbA:undetectable | 1eta1-5mfbA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfb | YIII(DQ)4CQI (syntheticconstruct) |
PF00514(Arm) | 4 | LEU A 181GLU A 219ALA A 222LEU A 184 | None | 0.93A | 1eta1-5mfbA:undetectable | 1eta1-5mfbA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfd | YIIIM''6AII (syntheticconstruct) |
PF00514(Arm) | 4 | LEU A 265GLU A 303ALA A 306LEU A 268 | None | 0.87A | 1eta1-5mfdA:undetectable | 1eta1-5mfdA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfo | YIIIM3AIII (syntheticconstruct) |
PF00514(Arm) | 4 | LEU A 139GLU A 177ALA A 180LEU A 142 | None | 0.87A | 1eta1-5mfoA:undetectable | 1eta1-5mfoA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4w | CULLIN-2 (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 4 | LEU A 53GLU A 51ALA A 48LEU A 45 | None | 1.03A | 1eta1-5n4wA:undetectable | 1eta1-5n4wA:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ofq | CYTOCHROME P450 (Bacillusmegaterium) |
PF00067(p450) | 4 | LEU A 226GLU A 224ALA A 219LEU A 216 | None | 1.17A | 1eta1-5ofqA:undetectable | 1eta1-5ofqA:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj8 | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Homo sapiens) |
PF07034(ORC3_N) | 4 | LEU A 219GLU A 223ALA A 138LEU A 136 | None | 1.17A | 1eta1-5uj8A:undetectable | 1eta1-5uj8A:10.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujs | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Campylobacterjejuni) |
PF00275(EPSP_synthase) | 4 | LYS A 180LEU A 182GLU A 213LEU A 156 | None | 0.61A | 1eta1-5ujsA:undetectable | 1eta1-5ujsA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz9 | CRISPR-ASSOCIATEDPROTEIN CSY1 (Pseudomonasaeruginosa) |
PF09611(Cas_Csy1) | 4 | LEU A 300GLU A 332ALA A 327LEU A 325 | None | 1.19A | 1eta1-5uz9A:undetectable | 1eta1-5uz9A:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wlg | T CELL RECEPTORALPHA VARIABLE8D-2,HUMAN NKT TCRALPHA CHAIN CHIMERA (Homo sapiens;Mus musculus) |
no annotation | 4 | LYS D 55GLU D 52ALA D 62LEU D 60 | None | 1.17A | 1eta1-5wlgD:3.8 | 1eta1-5wlgD:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xqo | PCRGLX PROTEIN (Penicilliumchrysogenum) |
no annotation | 4 | LEU A 672GLU A 724ALA A 717LEU A 675 | None | 1.16A | 1eta1-5xqoA:undetectable | 1eta1-5xqoA:21.97 |