SIMILAR PATTERNS OF AMINO ACIDS FOR 1ESW_A_ACRA652_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 TYR A 198
GLY A 227
GLY A 224
SER A 255
 None
 0.99A 1eswA-1bqcA:
7.1		 1eswA-1bqcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		4 TYR A 240
GLY A 284
GLY A 281
SER A 320
 BGC  A 402 ( 4.7A)
None
None
None
 0.98A 1eswA-1eceA:
2.6		 1eswA-1eceA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		4 GLY A  68
GLY A 100
TYR A  47
SER A  66
 GNP  A 593 (-3.8A)
GNP  A 593 (-3.1A)
None
None
 0.99A 1eswA-1f5nA:
undetectable		 1eswA-1f5nA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 706
GLY A 245
TYR A 313
SER A 700
 None
None
FCI  A 750 (-3.7A)
None
 0.98A 1eswA-1fcpA:
undetectable		 1eswA-1fcpA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		6 TYR A  54
GLY A  55
ASP A  56
GLY A  98
TYR A 101
SER A 470
 None
 0.75A 1eswA-1fp9A:
61.1		 1eswA-1fp9A:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TYR A 195
GLY A 194
GLY A 187
SER A 144
 None
None
AMI  A1391 (-3.3A)
AMI  A1391 ( 4.9A)
 0.99A 1eswA-1hkkA:
4.7		 1eswA-1hkkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 TYR A  65
GLY A  97
GLY A 105
TYR A 104
 U  D 917 ( 4.4A)
None
None
U  D 917 ( 3.1A)
 0.99A 1eswA-1j2bA:
6.6		 1eswA-1j2bA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		4 GLY A 220
ASP A 189
GLY A 216
SER A 146
 None
 0.83A 1eswA-1npmA:
undetectable		 1eswA-1npmA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc)
PF14671
(DSPn) 		4 GLY A 354
ASP A 167
GLY A 171
TYR A 170
 None
 0.96A 1eswA-1oheA:
undetectable		 1eswA-1oheA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		4 GLY A  88
GLY A  20
TYR A  19
SER A  90
 None
 0.97A 1eswA-1qozA:
undetectable		 1eswA-1qozA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13531
(SBP_bac_11) 		4 GLY A  43
ASP A  11
GLY A 175
SER A 129
 None
 0.92A 1eswA-1sbpA:
undetectable		 1eswA-1sbpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp8 HYPOTHETICAL PROTEIN
AF0103

(Archaeoglobus
fulgidus) 		PF02887
(PK_C) 		4 GLY A  12
ASP A 160
GLY A 125
SER A 156
 None
None
None
FMN  A 500 (-3.7A)
 0.57A 1eswA-1vp8A:
undetectable		 1eswA-1vp8A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TYR A 195
GLY A 194
GLY A 187
SER A 144
 None
 1.00A 1eswA-1wb0A:
4.6		 1eswA-1wb0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 TYR A 225
GLY A 255
GLY A 252
SER A 283
 None
 0.99A 1eswA-1wkyA:
9.3		 1eswA-1wkyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 TYR A  43
GLY A  55
ASP A  52
GLY A  47
 None
None
CA  A 601 (-3.5A)
None
 0.77A 1eswA-1wzaA:
16.0		 1eswA-1wzaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 GLY A 203
ASP A 208
GLY A 168
TYR A 206
 None
MG  A 300 ( 4.4A)
None
None
 0.95A 1eswA-1wzcA:
undetectable		 1eswA-1wzcA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 GLY A  54
ASP A  57
GLY A  29
SER A  52
 None
 0.79A 1eswA-1y3tA:
undetectable		 1eswA-1y3tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 GLY A  54
ASP A  57
TYR A 142
SER A  52
 None
 0.83A 1eswA-1y3tA:
undetectable		 1eswA-1y3tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 TYR A 285
GLY A 104
ASP A 109
SER A 102
 None
 0.93A 1eswA-2bwgA:
6.4		 1eswA-2bwgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		4 TYR A 235
GLY A 234
GLY A 146
TYR A 229
 None
None
GOL  A 370 (-3.4A)
None
 0.97A 1eswA-2hoeA:
undetectable		 1eswA-2hoeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 GLY A1762
ASP A1764
GLY A1909
TYR A1734
 None
 0.75A 1eswA-2ix8A:
undetectable		 1eswA-2ix8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 GLY A 298
ASP A 297
GLY A 351
SER A  83
 None
HEM  A 501 (-2.8A)
HEM  A 501 (-3.5A)
None
 0.96A 1eswA-2m56A:
undetectable		 1eswA-2m56A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 GLY B 241
GLY B 244
TYR B 245
SER B 192
 None
 1.00A 1eswA-2p1nB:
undetectable		 1eswA-2p1nB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3b YJEF-RELATED PROTEIN

(Enterococcus
faecalis) 		PF01256
(Carb_kinase) 		4 GLY A 213
ASP A 216
GLY A  38
TYR A  37
 EDO  A 294 (-3.3A)
EDO  A 294 (-3.4A)
None
None
 0.95A 1eswA-2r3bA:
undetectable		 1eswA-2r3bA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sn3 SCORPION NEUROTOXIN
(VARIANT 3)

(Centruroides
exilicauda) 		PF00537
(Toxin_3) 		4 TYR A  40
GLY A  39
GLY A   3
TYR A   4
 None
 0.86A 1eswA-2sn3A:
undetectable		 1eswA-2sn3A:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Aquifex
aeolicus) 		PF00288
(GHMP_kinases_N) 		4 GLY A 239
GLY A 172
TYR A 175
SER A 168
 None
CDP  A1269 (-3.4A)
CDP  A1269 (-3.6A)
None
 0.79A 1eswA-2v8pA:
undetectable		 1eswA-2v8pA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vou 2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE

(Paenarthrobacter
nicotinovorans) 		PF00070
(Pyr_redox) 		4 GLY A 305
ASP A 325
GLY A 354
TYR A 357
 FAD  A1395 (-3.5A)
None
None
ACT  A1397 (-4.5A)
 0.83A 1eswA-2vouA:
undetectable		 1eswA-2vouA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		4 GLY A 386
GLY A 433
TYR A 434
SER A 384
 None
 0.96A 1eswA-2vpjA:
undetectable		 1eswA-2vpjA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		4 GLY A  55
ASP A  56
GLY A  98
SER A 470
 None
 0.72A 1eswA-2x1iA:
60.4		 1eswA-2x1iA:
86.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		5 TYR A  54
GLY A  55
ASP A  56
GLY A  98
TYR A 101
 None
 0.47A 1eswA-2x1iA:
60.4		 1eswA-2x1iA:
86.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 TYR A 194
GLY A 262
GLY A 401
TYR A 404
 None
 0.73A 1eswA-2yevA:
undetectable		 1eswA-2yevA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 TYR A 299
GLY A 344
GLY A 341
SER A 378
 None
 0.97A 1eswA-3axxA:
8.7		 1eswA-3axxA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgk PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF01256
(Carb_kinase) 		4 GLY A 214
ASP A 217
GLY A  37
TYR A  36
 PO4  A 278 (-3.3A)
PO4  A 278 (-3.1A)
None
None
 0.97A 1eswA-3bgkA:
undetectable		 1eswA-3bgkA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu1 LIPOCALIN

(Argas
monolakensis) 		PF02098
(His_binding) 		4 TYR A  21
GLY A  20
GLY A  17
SER A 109
 HSM  A 301 (-3.2A)
None
None
None
 0.94A 1eswA-3bu1A:
undetectable		 1eswA-3bu1A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 TYR A 277
GLY A 276
GLY A  63
TYR A  64
 None
 0.88A 1eswA-3ehmA:
undetectable		 1eswA-3ehmA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewn THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF01965
(DJ-1_PfpI) 		4 GLY A 122
ASP A  68
GLY A 204
SER A 152
 None
GOL  A3968 ( 4.7A)
None
None
 0.78A 1eswA-3ewnA:
undetectable		 1eswA-3ewnA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y UL16

(Homo sapiens) 		PF00252
(Ribosomal_L16) 		4 TYR N 241
GLY N  74
GLY N  93
SER N  76
 None
 0.94A 1eswA-3j7yN:
undetectable		 1eswA-3j7yN:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 168
GLY A 190
TYR A 189
SER A 173
 None
 0.89A 1eswA-3k5pA:
undetectable		 1eswA-3k5pA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k80 ANTIBODY

(Lama glama) 		PF07686
(V-set) 		4 TYR A 111
GLY A  98
GLY A 102
TYR A 101
 None
 0.95A 1eswA-3k80A:
undetectable		 1eswA-3k80A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		4 TYR A 558
GLY A  84
ASP A  81
GLY A  76
 None
None
MG  A 700 (-3.3A)
None
 0.93A 1eswA-3k8kA:
15.4		 1eswA-3k8kA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  45
GLY A  44
ASP A 108
GLY A 351
 None
 0.96A 1eswA-3kumA:
undetectable		 1eswA-3kumA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0c LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 GLY C 322
ASP C 333
GLY C 353
TYR C 354
 None
CA  C1002 (-3.2A)
None
None
 0.94A 1eswA-3m0cC:
undetectable		 1eswA-3m0cC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7k RESTRICTION
ENDONUCLEASE PACI

(Pseudomonas
alcaligenes) 		no annotation 4 TYR A 100
GLY A  99
GLY A  41
SER A  96
 None
None
None
MG  A 145 ( 4.7A)
 0.99A 1eswA-3m7kA:
undetectable		 1eswA-3m7kA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)

(Clostridium
acetobutylicum) 		PF01965
(DJ-1_PfpI) 		4 GLY A  71
ASP A  17
GLY A 155
SER A 100
 None
 0.69A 1eswA-3mgkA:
undetectable		 1eswA-3mgkA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)

(Clostridium
acetobutylicum) 		PF01965
(DJ-1_PfpI) 		4 GLY A  71
ASP A  17
GLY A 155
SER A 105
 None
 0.89A 1eswA-3mgkA:
undetectable		 1eswA-3mgkA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY A 709
ASP A 714
GLY A 213
SER A 368
 PHD  A 369 ( 3.5A)
PHD  A 369 ( 2.9A)
PHD  A 369 ( 2.8A)
PHD  A 369 ( 2.6A)
 0.79A 1eswA-3n23A:
undetectable		 1eswA-3n23A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
fluorescens) 		PF01965
(DJ-1_PfpI) 		4 GLY A  70
ASP A  17
GLY A 151
SER A  99
 NHE  A 501 ( 4.7A)
EDO  A 604 ( 4.6A)
None
None
 0.78A 1eswA-3noqA:
undetectable		 1eswA-3noqA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN

(Listeria
monocytogenes) 		PF02126
(PTE) 		4 GLY A 239
ASP A 217
GLY A 214
SER A 270
 None
 0.92A 1eswA-3pnzA:
5.3		 1eswA-3pnzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  45
GLY A  44
ASP A 108
GLY A 351
 None
 0.89A 1eswA-3q4dA:
2.4		 1eswA-3q4dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  47
GLY A  46
ASP A 111
GLY A 354
 None
 0.92A 1eswA-3r11A:
2.9		 1eswA-3r11A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 TYR A 331
GLY A 310
GLY A 272
SER A  54
 None
None
None
CL  A 801 (-3.0A)
 0.73A 1eswA-3thcA:
11.5		 1eswA-3thcA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN 98

(Mus musculus) 		PF04096
(Nucleoporin2) 		4 TYR C 772
GLY C 771
GLY C 740
TYR C 741
 None
 0.78A 1eswA-3tknC:
undetectable		 1eswA-3tknC:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		4 GLY A 277
ASP A  71
GLY A  91
SER A  14
 None
 0.94A 1eswA-3tqeA:
undetectable		 1eswA-3tqeA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  51
GLY A  50
ASP A 114
GLY A 365
 None
 0.98A 1eswA-3u9iA:
3.8		 1eswA-3u9iA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 319
GLY A  41
TYR A  40
SER A 317
 None
 0.95A 1eswA-3v8uA:
undetectable		 1eswA-3v8uA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLY A 318
GLY A  42
TYR A  41
SER A 316
 None
 0.93A 1eswA-3ve2A:
undetectable		 1eswA-3ve2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A 166
GLY A 190
TYR A 186
SER A 169
 None
 0.95A 1eswA-3vi3A:
undetectable		 1eswA-3vi3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		4 GLY A 335
GLY A 331
TYR A 332
SER A 339
 None
 0.85A 1eswA-3vmlA:
undetectable		 1eswA-3vmlA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		4 TYR A 310
GLY A 293
GLY A 254
SER A  45
 None
None
None
CL  A 807 (-3.0A)
 0.78A 1eswA-3w5fA:
8.1		 1eswA-3w5fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 TYR A 299
GLY A 344
GLY A 341
SER A 378
 None
 0.95A 1eswA-3w6mA:
8.3		 1eswA-3w6mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win HA3

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 GLY D 104
GLY D 150
TYR D 123
SER E 246
 None
 0.89A 1eswA-3winD:
undetectable		 1eswA-3winD:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A  50
GLY A  62
ASP A  59
GLY A  56
 None
None
MG  A1592 (-3.1A)
None
 0.99A 1eswA-3zo9A:
16.3		 1eswA-3zo9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 TYR A 162
GLY A 163
GLY A 292
SER A 132
 None
 0.93A 1eswA-4bziA:
undetectable		 1eswA-4bziA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		4 GLY A 423
GLY A 449
TYR A 453
SER A 443
 None
 0.96A 1eswA-4eljA:
undetectable		 1eswA-4eljA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Salmonella
enterica) 		PF12710
(HAD) 		4 GLY A 249
ASP A 252
GLY A 181
SER A  95
 None
NA  A 302 ( 4.3A)
None
None
 0.91A 1eswA-4ezeA:
undetectable		 1eswA-4ezeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  35
GLY A  34
ASP A  99
GLY A 366
 None
 0.91A 1eswA-4gisA:
6.2		 1eswA-4gisA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt6 CELL SURFACE PROTEIN

(Faecalibacterium
prausnitzii) 		PF13306
(LRR_5) 		4 TYR A 184
GLY A 207
GLY A 180
SER A 228
 None
EDO  A 906 ( 4.7A)
None
EDO  A 905 (-2.6A)
 0.79A 1eswA-4gt6A:
undetectable		 1eswA-4gt6A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 GLY A 189
GLY A 185
TYR A 213
SER A  54
 None
None
None
MN  A 301 (-2.1A)
 0.90A 1eswA-4hqnA:
undetectable		 1eswA-4hqnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12

(Homo sapiens;
Oryctolagus
cuniculus) 		PF00229
(TNF)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H 101
GLY H 100
ASP H 105
GLY T  33
 None
 0.97A 1eswA-4ht1H:
undetectable		 1eswA-4ht1H:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij3 HEAVY CHAIN OF FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY C 101
ASP C  98
GLY C  33
TYR C  32
 None
 0.87A 1eswA-4ij3C:
undetectable		 1eswA-4ij3C:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb3 HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 TYR A  40
GLY A 173
ASP A 171
GLY A  10
 None
None
NA  A 301 ( 4.4A)
NA  A 301 (-4.4A)
 0.83A 1eswA-4jb3A:
undetectable		 1eswA-4jb3A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 GLY A  61
ASP A  80
TYR A 127
SER A  84
 SAH  A 502 (-3.4A)
SAH  A 502 (-2.5A)
SAH  A 502 (-4.9A)
None
 0.93A 1eswA-4krgA:
undetectable		 1eswA-4krgA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		4 GLY A  10
ASP A  34
TYR A  37
SER A  17
 NAD  A 402 ( 3.8A)
NAD  A 402 (-2.5A)
None
None
 0.93A 1eswA-4lisA:
2.3		 1eswA-4lisA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 338
GLY A 337
GLY A 334
SER A 266
 None
 0.96A 1eswA-4lr2A:
undetectable		 1eswA-4lr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A  19
GLY A  31
ASP A  28
GLY A  23
 None
None
CA  A 603 (-3.2A)
None
 0.68A 1eswA-4m8uA:
17.9		 1eswA-4m8uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 177
GLY A 201
GLY A 174
SER A 224
 None
 0.97A 1eswA-4mn8A:
undetectable		 1eswA-4mn8A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		4 TYR A 107
GLY A 106
GLY A  49
SER A 103
 None
 0.93A 1eswA-4o6qA:
undetectable		 1eswA-4o6qA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 GLY A  86
ASP A  85
GLY A  99
SER A  34
 FLC  A 300 ( 4.5A)
None
FLC  A 300 (-3.8A)
FLC  A 300 (-2.7A)
 0.99A 1eswA-4x84A:
undetectable		 1eswA-4x84A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 248
ASP A 250
GLY A 201
SER A 430
 MGD  A1003 (-3.8A)
MGD  A1003 (-2.8A)
MGD  A1003 (-3.4A)
None
 0.91A 1eswA-5chcA:
undetectable		 1eswA-5chcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 TYR A 167
GLY A 168
GLY A  77
SER A 105
 None
 0.94A 1eswA-5dkxA:
12.0		 1eswA-5dkxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyy S-LOCUS PROTEIN 11
S-RECEPTOR KINASE
SRK9

(Brassica rapa) 		PF00954
(S_locus_glycop)
PF01453
(B_lectin)
PF06876
(SCRL)
PF08276
(PAN_2) 		4 GLY G  20
ASP G  23
GLY A  47
SER G  15
 None
 0.72A 1eswA-5gyyG:
undetectable		 1eswA-5gyyG:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5d INNER MEMBRANE
PROTEIN YEJM

(Salmonella
enterica) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		4 TYR A 317
GLY A 316
GLY A 312
TYR A 311
 None
 0.96A 1eswA-5i5dA:
undetectable		 1eswA-5i5dA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLY A 809
ASP A 811
GLY A 157
TYR A 166
 None
 0.90A 1eswA-5ihrA:
9.3		 1eswA-5ihrA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp3 XANTHOMONAS OUTER
PROTEIN D

(Xanthomonas
euvesicatoria) 		PF02902
(Peptidase_C48) 		4 TYR A 468
GLY A 467
GLY A 471
SER A 465
 None
 0.96A 1eswA-5jp3A:
undetectable		 1eswA-5jp3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA

(Staphylococcus
aureus) 		PF03255
(ACCA) 		4 TYR A 133
GLY A 132
ASP A  91
GLY A 126
 None
 1.00A 1eswA-5kdrA:
undetectable		 1eswA-5kdrA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLY A  84
GLY A  40
TYR A 488
SER A  86
 None
None
None
ZN  A 605 (-1.9A)
 0.85A 1eswA-5kgnA:
undetectable		 1eswA-5kgnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 TYR B  41
GLY B  53
ASP B  50
GLY B  45
 None
None
NA  B 602 (-3.4A)
None
 0.73A 1eswA-5m99B:
17.0		 1eswA-5m99B:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 TYR B 393
GLY B 407
ASP B 406
GLY B 401
 None
None
NA  B 601 (-2.3A)
NA  B 601 (-4.2A)
 1.00A 1eswA-5m99B:
17.0		 1eswA-5m99B:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 GLY A 542
ASP A 371
GLY A 708
SER A 414
 None
 0.96A 1eswA-5mfaA:
undetectable		 1eswA-5mfaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 4 GLY A 221
ASP A 189
GLY A 216
SER A 146
 None
 0.82A 1eswA-5ms3A:
undetectable		 1eswA-5ms3A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtf RHOMBOID PROTEASE
GLPG

(Escherichia
coli) 		no annotation 4 GLY A 257
GLY A 186
TYR A 187
SER A 201
 None
 0.96A 1eswA-5mtfA:
undetectable		 1eswA-5mtfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		4 GLY A 278
ASP A 279
GLY A 271
SER A 276
 None
 0.98A 1eswA-5tzbA:
undetectable		 1eswA-5tzbA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 TYR A 341
GLY A 340
GLY A 337
SER A 267
 None
 0.97A 1eswA-5vemA:
undetectable		 1eswA-5vemA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		4 TYR A 341
GLY A 340
GLY A 337
SER A 267
 None
 0.98A 1eswA-5veoA:
undetectable		 1eswA-5veoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 GLY A  63
ASP A  82
TYR A 131
SER A  86
 SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 ( 4.8A)
None
 0.98A 1eswA-5wp5A:
undetectable		 1eswA-5wp5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN

(Citrobacter sp.
MGH106) 		no annotation 4 GLY S  82
ASP S  81
GLY S  24
SER S 119
 8JU  S 404 (-3.7A)
8JU  S 404 ( 2.5A)
8JU  S 404 (-3.7A)
8JU  S 404 ( 4.9A)
 0.98A 1eswA-5xvdS:
undetectable		 1eswA-5xvdS:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 GLY A 542
ASP A 371
GLY A 708
SER A 414
 None
 0.95A 1eswA-6azpA:
undetectable		 1eswA-6azpA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byx SHORT ULVAN LYASE

(Alteromonas sp.
LOR) 		no annotation 4 GLY A 388
GLY A 304
TYR A 303
SER A 442
 GOL  A 612 (-3.4A)
GOL  A 611 (-3.7A)
GOL  A 611 (-4.5A)
GOL  A 612 ( 4.9A)
 0.76A 1eswA-6byxA:
undetectable		 1eswA-6byxA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehe OMPT PROTEIN

(Vibrio cholerae) 		no annotation 4 TYR A  95
GLY A 107
TYR A 215
SER A 100
 None
 0.79A 1eswA-6eheA:
undetectable		 1eswA-6eheA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 TYR A  14
GLY A  45
GLY A 133
SER A  65
 None
 0.90A 1eswA-6eroA:
undetectable		 1eswA-6eroA:
21.92