SIMILAR PATTERNS OF AMINO ACIDS FOR 1ESW_A_ACRA651_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		7 SER A  57
TYR A  59
GLN A  60
TRP A 258
HIS A 394
ASN A 464
TRP A 473
 None
 0.76A 1eswA-1fp9A:
61.1		 1eswA-1fp9A:
99.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		11 SER A  57
TYR A  59
GLN A 256
TRP A 258
HIS A 294
GLU A 340
HIS A 394
ASP A 395
ASN A 464
PRO A 466
TRP A 473
 None
 0.42A 1eswA-1fp9A:
61.1		 1eswA-1fp9A:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 SER A 156
GLN A 312
TRP A 315
GLU A 414
ASN A 512
 None
 1.18A 1eswA-1gjuA:
20.6		 1eswA-1gjuA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 SER A 156
TYR A 158
GLN A 312
TRP A 315
ASN A 512
 None
 0.85A 1eswA-1gjuA:
20.6		 1eswA-1gjuA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  60
GLN A  61
HIS A 189
HIS A 286
ASP A 287
 None
 1.12A 1eswA-1jaeA:
16.2		 1eswA-1jaeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  60
GLN A  61
HIS A 286
ASP A 287
TRP A  56
 None
 0.98A 1eswA-1jaeA:
16.2		 1eswA-1jaeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  62
GLN A  63
HIS A 201
HIS A 299
ASP A 300
 None
 1.08A 1eswA-1jxkA:
11.6		 1eswA-1jxkA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  50
GLN A  51
HIS A 178
HIS A 263
ASP A 264
 ACR  A 598 (-4.5A)
ACR  A 598 (-3.7A)
None
None
ACR  A 598 (-3.1A)
 1.16A 1eswA-1kxhA:
13.6		 1eswA-1kxhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  50
GLN A  51
HIS A 263
ASP A 264
TRP A  46
 ACR  A 598 (-4.5A)
ACR  A 598 (-3.7A)
None
ACR  A 598 (-3.1A)
None
 0.96A 1eswA-1kxhA:
13.6		 1eswA-1kxhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  62
GLN A  63
HIS A 201
GLU A 233
HIS A 299
 AC1  A 992 ( 3.6A)
GLC  A 991 ( 3.7A)
AC1  A 992 ( 3.8A)
AC1  A 992 ( 2.7A)
AC1  A 992 ( 3.9A)
 1.14A 1eswA-1oseA:
14.1		 1eswA-1oseA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  62
GLN A  63
HIS A 299
ASP A 300
TRP A  58
 AC1  A 992 ( 3.6A)
GLC  A 991 ( 3.7A)
AC1  A 992 ( 3.9A)
AC1  A 992 (-3.0A)
None
 1.01A 1eswA-1oseA:
14.1		 1eswA-1oseA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		10 SER A  56
TYR A  58
GLN A 249
TRP A 251
HIS A 287
GLU A 333
HIS A 384
ASP A 385
ASN A 450
TRP A 459
 None
 0.60A 1eswA-1tz7A:
51.4		 1eswA-1tz7A:
44.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		10 SER A  56
TYR A  58
TRP A 251
HIS A 287
GLU A 333
HIS A 384
ASP A 385
ASN A 450
PRO A 452
TRP A 459
 None
 0.61A 1eswA-1tz7A:
51.4		 1eswA-1tz7A:
44.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		5 TYR A  62
GLN A  63
HIS A 268
ASP A 269
TRP A  58
 ACI  A 504 ( 3.7A)
GLC  A 503 ( 3.9A)
ACI  A 504 (-3.8A)
ACI  A 504 ( 2.8A)
None
 0.92A 1eswA-1ua7A:
15.1		 1eswA-1ua7A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TYR A  58
HIS A 240
HIS A 332
ASP A 333
TRP A  15
 AC1  A1492 ( 3.9A)
AC1  A1492 ( 3.9A)
AC1  A1492 (-3.9A)
AC1  A1492 ( 3.0A)
None
 1.27A 1eswA-1w9xA:
15.2		 1eswA-1w9xA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		11 SER A  82
TYR A  84
GLN A 284
TRP A 286
HIS A 322
GLU A 368
HIS A 420
ASP A 421
ASN A 485
PRO A 487
TRP A 494
 GOL  A1001 ( 4.5A)
GOL  A1001 ( 3.8A)
None
GOL  A1002 (-3.4A)
None
None
GOL  A1001 (-4.0A)
GOL  A1001 (-2.6A)
GOL  A1001 (-4.4A)
None
None
 0.70A 1eswA-1x1nA:
48.9		 1eswA-1x1nA:
43.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		6 SER A  57
GLN A  60
GLN A 256
ASN A 464
PRO A 466
TRP A 473
 None
 1.08A 1eswA-2x1iA:
60.4		 1eswA-2x1iA:
86.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		11 SER A  57
TYR A  59
GLN A 256
TRP A 258
HIS A 294
GLU A 340
HIS A 394
ASP A 395
ASN A 464
PRO A 466
TRP A 473
 None
 0.32A 1eswA-2x1iA:
60.4		 1eswA-2x1iA:
86.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 TYR A 184
HIS A 354
HIS A 446
ASP A 447
TRP A 131
 ACI  A 806 ( 4.0A)
GLD  A 807 ( 3.8A)
ACI  A 806 (-4.1A)
ACI  A 806 (-2.9A)
None
 1.30A 1eswA-3bc9A:
14.8		 1eswA-3bc9A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 TYR A1210
GLN A 590
HIS A 604
HIS A 854
ASP A 855
 None
 1.47A 1eswA-3egwA:
undetectable		 1eswA-3egwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		6 TYR A 306
GLN A 307
GLU A 464
HIS A 531
ASP A 532
TRP A 304
 None
 1.14A 1eswA-3k1dA:
18.2		 1eswA-3k1dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 TYR A 163
TRP A 227
GLU A 296
HIS A 392
TRP A 161
 BTB  A 605 (-3.6A)
BTB  A 605 (-3.1A)
MG  A 597 (-3.9A)
BTB  A 605 (-4.1A)
None
 1.15A 1eswA-3m07A:
18.8		 1eswA-3m07A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm5 ALPHA-AMYLASE

(Oryzias latipes) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 TYR A  62
GLN A  63
HIS A 299
ASP A 300
TRP A  58
 None
 1.00A 1eswA-3vm5A:
13.8		 1eswA-3vm5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		6 TYR A 300
GLN A 301
GLU A 458
HIS A 525
ASP A 526
TRP A 298
 None
 1.15A 1eswA-4lq1A:
15.8		 1eswA-4lq1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		11 SER A 199
TYR A 201
GLN A 411
TRP A 413
HIS A 449
GLU A 496
HIS A 547
ASP A 548
ASN A 648
PRO A 650
TRP A 659
 None
 0.41A 1eswA-4s3pA:
34.6		 1eswA-4s3pA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		6 SER A 134
TYR A 136
GLN A 336
HIS A 374
GLU A 420
HIS A 472
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.6A)
AGL  A 607 ( 3.8A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
 0.84A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		8 SER A 134
TYR A 136
GLU A 420
HIS A 472
ASP A 473
ASN A 537
PRO A 539
TRP A 546
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
GLC  A 605 ( 3.7A)
GLC  A 605 ( 3.6A)
None
 0.48A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		6 SER A 134
TYR A 136
HIS A 374
GLU A 420
HIS A 472
TRP A 546
 GLC  A 605 ( 2.8A)
HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.8A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
None
 0.71A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		6 TYR A 136
GLN A 336
TRP A 338
HIS A 374
GLU A 420
HIS A 472
 HMC  A 606 ( 4.0A)
AGL  A 607 ( 3.6A)
HMC  A 606 ( 3.6A)
AGL  A 607 ( 3.8A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
 0.83A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		5 TYR A 136
TRP A 338
GLU A 420
HIS A 472
ASP A 473
 HMC  A 606 ( 4.0A)
HMC  A 606 ( 3.6A)
AGL  A 607 ( 2.7A)
HMC  A 606 ( 3.8A)
HMC  A 606 ( 2.8A)
 0.92A 1eswA-5csuA:
48.3		 1eswA-5csuA:
38.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		6 TYR A 329
GLN A 330
GLU A 487
HIS A 554
ASP A 555
TRP A 327
 None
None
MG  A 826 (-3.9A)
None
None
None
 1.16A 1eswA-5gr1A:
11.2		 1eswA-5gr1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		6 TYR A 329
TRP A 399
GLU A 487
HIS A 554
ASP A 555
TRP A 327
 None
None
MG  A 826 (-3.9A)
None
None
None
 1.37A 1eswA-5gr1A:
11.2		 1eswA-5gr1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		11 SER A 233
TYR A 235
GLN A 423
TRP A 425
HIS A 461
GLU A 508
HIS A 560
ASP A 561
ASN A 661
PRO A 663
TRP A 673
 None
None
None
None
None
None
None
None
SO4  A 803 (-3.0A)
SO4  A 803 (-3.8A)
None
 0.70A 1eswA-5jjhA:
34.0		 1eswA-5jjhA:
23.21