SIMILAR PATTERNS OF AMINO ACIDS FOR 1ERR_B_RALB600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4a ARGININE REPRESSOR

(Geobacillus
stearothermophilus)
PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C)
5 LEU A  94
LEU A  93
ILE A 122
LEU A  80
LEU A 149
None
1.21A 1errB-1b4aA:
undetectable
1errB-1b4aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE


(Ovis aries)
PF00008
(EGF)
PF03098
(An_peroxidase)
5 LEU A 177
LEU A 182
ILE A 188
LEU A 491
LEU A 494
None
1.15A 1errB-1ebvA:
undetectable
1errB-1ebvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis)
PF00082
(Peptidase_S8)
5 LEU 1 355
LEU 1 356
ILE 1 349
LEU 1 287
LEU 1 188
None
1.19A 1errB-1gt91:
undetectable
1errB-1gt91:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster)
PF00104
(Hormone_recep)
6 TRP A 318
LEU A 322
ILE A 385
LEU A 476
LEU A 487
LEU A 490
None
LPP  A   1 ( 4.8A)
None
LPP  A   1 (-4.2A)
None
None
0.89A 1errB-1hg4A:
24.1
1errB-1hg4A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
5 TRP A 667
LEU A  23
ILE A  81
LEU A 614
LEU A 671
None
1.20A 1errB-1j1wA:
undetectable
1errB-1j1wA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS


(Thermus
aquaticus)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
5 GLU A 333
LEU A 332
LEU A 287
LEU A 359
LEU A 356
None
1.16A 1errB-1nneA:
undetectable
1errB-1nneA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE


(Escherichia
coli)
PF04055
(Radical_SAM)
PF06969
(HemN_C)
5 TRP A 110
LEU A 118
ILE A 151
LEU A 159
LEU A 108
None
1.15A 1errB-1oltA:
undetectable
1errB-1oltA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
8 ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
LEU A 525
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
0.59A 1errB-1pcgA:
32.2
1errB-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
7 THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
0.29A 1errB-1pcgA:
32.2
1errB-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 THR A 347
GLU A 353
LEU A 354
TRP A 383
ARG A 394
None
EST  A   1 (-2.8A)
None
None
EST  A   1 (-3.7A)
0.57A 1errB-1pcgA:
32.2
1errB-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans)
no annotation 5 ALA A 347
GLU A 350
LEU A 318
ILE A 286
LEU A 374
None
1.19A 1errB-1pgvA:
undetectable
1errB-1pgvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B


(Escherichia
coli)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
5 THR A1264
ALA A1317
LEU A1253
LEU A1230
LEU A1287
None
1.21A 1errB-1s16A:
undetectable
1errB-1s16A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
5 LEU A 665
LEU A 532
ILE A 691
LEU A 292
LEU A 711
None
1.14A 1errB-1t6pA:
undetectable
1errB-1t6pA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlq HYPOTHETICAL PROTEIN
YPJQ


(Bacillus
subtilis)
PF04608
(PgpA)
5 ALA A 149
LEU A 150
LEU A 104
ILE A  98
LEU A  19
None
1.05A 1errB-1tlqA:
undetectable
1errB-1tlqA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR


(Geobacillus
stearothermophilus)
PF12146
(Hydrolase_4)
5 THR A 163
ALA A 166
GLU A 169
LEU A 170
LEU A  95
None
None
None
None
4PA  A 701 (-4.2A)
1.06A 1errB-1tqhA:
undetectable
1errB-1tqhA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 343
TRP A 376
LEU A 380
ARG A 387
ILE A 499
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
0.98A 1errB-1uhlA:
22.5
1errB-1uhlA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE


(Vibrio
parahaemolyticus)
PF04952
(AstE_AspA)
5 ALA A  68
GLU A  71
LEU A  72
LEU A 231
LEU A 241
None
0.96A 1errB-2bcoA:
undetectable
1errB-2bcoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3


(Rattus
norvegicus)
PF01094
(ANF_receptor)
PF07562
(NCD3G)
5 ALA A 403
GLU A 433
LEU A 404
LEU A  41
LEU A  91
None
1.21A 1errB-2e4uA:
undetectable
1errB-2e4uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
5 GLU A 366
LEU A 373
LEU A 445
LEU A 431
LEU A 390
None
1.21A 1errB-2eu9A:
undetectable
1errB-2eu9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli)
PF00550
(PP-binding)
PF00857
(Isochorismatase)
5 ALA A 177
LEU A 178
ILE A  72
LEU A 206
LEU A 190
None
1.14A 1errB-2fq1A:
undetectable
1errB-2fq1A:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 272
GLU A 275
TRP A 305
LEU A 309
ARG A 316
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
None
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
0.52A 1errB-2gpvA:
26.0
1errB-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00005
(ABC_tran)
5 THR A 191
LEU A 157
LEU A  46
ILE A 212
LEU A 176
None
1.18A 1errB-2it1A:
undetectable
1errB-2it1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C


(Saccharomyces
cerevisiae)
PF12660
(zf-TFIIIC)
5 ALA A 462
LEU A 458
LEU A 475
LEU A 427
LEU A 430
None
0.87A 1errB-2j04A:
undetectable
1errB-2j04A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3q TUSP1

(Nephila
antipodiana)
PF16763
(Spidroin_N)
5 ALA A  11
LEU A  10
LEU A  33
LEU A  87
LEU A  91
None
1.08A 1errB-2k3qA:
undetectable
1errB-2k3qA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 THR A 248
LEU A 104
LEU A 101
LEU A 163
LEU A 159
None
1.23A 1errB-2o1wA:
undetectable
1errB-2o1wA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 525
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-3.6A)
0.76A 1errB-2ocfA:
31.1
1errB-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
8 THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
0.66A 1errB-2ocfA:
31.1
1errB-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 THR A 347
GLU A 353
LEU A 354
TRP A 383
LEU A 391
ARG A 394
None
EST  A 596 (-2.7A)
None
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
0.70A 1errB-2ocfA:
31.1
1errB-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql2 NEUROGENIC
DIFFERENTIATION
FACTOR 1
TRANSCRIPTION FACTOR
E2-ALPHA


(Mus musculus)
PF00010
(HLH)
5 ALA A 561
GLU A 564
LEU A 565
LEU B 124
LEU A 585
None
1.00A 1errB-2ql2A:
undetectable
1errB-2ql2A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9


(Homo sapiens)
PF06821
(Ser_hydrolase)
5 ALA A  92
LEU A 181
LEU A 182
ILE A 175
LEU A 153
None
1.18A 1errB-2qs9A:
undetectable
1errB-2qs9A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE


(Pseudomonas
syringae group
genomosp. 3)
PF04198
(Sugar-bind)
5 ALA A 100
LEU A 104
LEU A 281
ILE A 213
LEU A 164
None
0.97A 1errB-2r5fA:
undetectable
1errB-2r5fA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vec PIRIN-LIKE PROTEIN
YHAK


(Escherichia
coli)
PF02678
(Pirin)
5 LEU A  91
LEU A  92
ILE A 143
LEU A 112
LEU A  48
None
1.19A 1errB-2vecA:
undetectable
1errB-2vecA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus)
PF06745
(ATPase)
5 ALA A 134
LEU A 135
LEU A  91
ILE A  66
LEU A 150
None
0.99A 1errB-2w0mA:
undetectable
1errB-2w0mA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE


(Paraburkholderia
caryophylli)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 102
None
0.81A 1errB-2w8sA:
undetectable
1errB-2w8sA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE


(Streptomyces
vinaceus)
PF02668
(TauD)
5 ALA A 125
LEU A 127
LEU A  57
ARG A 353
LEU A  71
None
1.24A 1errB-2wbpA:
undetectable
1errB-2wbpA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN


(Bordetella
bronchiseptica)
PF04183
(IucA_IucC)
PF06276
(FhuF)
5 LEU A 424
TRP A 423
LEU A 409
ILE A 154
LEU A 455
None
1.15A 1errB-2x0qA:
undetectable
1errB-2x0qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1


(Homo sapiens)
PF09770
(PAT1)
5 THR A 616
ALA A 617
LEU A 659
LEU A 644
LEU A 647
None
1.12A 1errB-2xesA:
undetectable
1errB-2xesA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypb T-CELL ACUTE
LYMPHOCYTIC LEUKEMIA
PROTEIN 1
TRANSCRIPTION FACTOR
E2-ALPHA


(Homo sapiens)
PF00010
(HLH)
5 ALA A 206
GLU A 209
LEU A 210
LEU B 569
LEU A 229
None
1.04A 1errB-2ypbA:
undetectable
1errB-2ypbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypb T-CELL ACUTE
LYMPHOCYTIC LEUKEMIA
PROTEIN 1
TRANSCRIPTION FACTOR
E2-ALPHA


(Homo sapiens)
PF00010
(HLH)
5 ALA B 565
GLU B 568
LEU B 569
LEU A 210
LEU B 589
None
0.97A 1errB-2ypbB:
undetectable
1errB-2ypbB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE


(Geobacillus
kaustophilus)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 ALA A 256
GLU A 260
LEU A 257
LEU A 109
LEU A 268
None
0.89A 1errB-2ys6A:
undetectable
1errB-2ys6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE


(Shewanella sp.)
PF00149
(Metallophos)
5 LEU A  90
ILE A 187
LEU A 145
LEU A  76
LEU A 315
None
1.00A 1errB-2zbmA:
undetectable
1errB-2zbmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE


(Achromobacter
obae)
PF00202
(Aminotran_3)
5 ALA A  89
GLU A  90
LEU A  88
LEU A 275
LEU A 269
None
1.20A 1errB-2zukA:
undetectable
1errB-2zukA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE


(Pyrococcus sp.
GI-H)
PF09019
(EcoRII-C)
5 LEU A 111
ILE A  66
LEU A  31
LEU A  37
LEU A  40
None
1.23A 1errB-3bm3A:
undetectable
1errB-3bm3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C)
5 GLU C 356
LEU C 355
ILE C  52
LEU C 317
LEU C 314
None
1.06A 1errB-3degC:
undetectable
1errB-3degC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
5 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ILE A 428
9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
None
0.87A 1errB-3dzuA:
22.1
1errB-3dzuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE


(Neisseria
meningitidis)
PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M)
5 THR A 154
ALA A 133
GLU A 128
LEU A 132
ILE A  20
None
1.21A 1errB-3eagA:
undetectable
1errB-3eagA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE


(Salmonella
enterica)
PF13378
(MR_MLE_C)
5 ALA A  90
LEU A  91
LEU A  34
LEU A  63
LEU A  77
None
1.22A 1errB-3gc2A:
undetectable
1errB-3gc2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF01030
(Recep_L_domain)
5 LEU A  40
ILE A 150
LEU A 120
LEU A  52
LEU A  49
None
1.20A 1errB-3h3bA:
undetectable
1errB-3h3bA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY


(Novosphingobium
aromaticivorans)
PF00370
(FGGY_N)
5 ALA A 155
LEU A 158
ILE A  79
LEU A  55
LEU A  59
None
1.17A 1errB-3h6eA:
undetectable
1errB-3h6eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Leptospira
interrogans)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ALA A 134
LEU A 136
LEU A 169
LEU A 142
LEU A 124
None
0.98A 1errB-3i3aA:
undetectable
1errB-3i3aA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Leptospira
interrogans)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 THR A 131
ALA A 134
LEU A 136
LEU A 142
LEU A 124
None
1.06A 1errB-3i3aA:
undetectable
1errB-3i3aA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2


(Saccharomyces
cerevisiae)
PF05916
(Sld5)
5 GLU B  97
LEU B  93
LEU B  98
ILE B 151
LEU B 126
None
1.12A 1errB-3jc7B:
undetectable
1errB-3jc7B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jw4 TRANSCRIPTIONAL
REGULATOR, MARR/EMRR
FAMILY


(Clostridium
acetobutylicum)
PF01047
(MarR)
5 ALA A 106
GLU A 109
LEU A 107
LEU A  34
LEU A  36
None
1.23A 1errB-3jw4A:
undetectable
1errB-3jw4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]


(Coxiella
burnetii)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 LEU A 293
ILE A  92
LEU A 119
LEU A 187
LEU A 226
None
1.12A 1errB-3k96A:
undetectable
1errB-3k96A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfq TRANSCRIPTION FACTOR
IWS1


(Saccharomyces
cerevisiae)
PF08711
(Med26)
5 ALA A 105
LEU A 106
LEU A  63
LEU A  56
LEU A  85
None
1.19A 1errB-3nfqA:
undetectable
1errB-3nfqA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1


(Homo sapiens)
PF02854
(MIF4G)
5 ALA A 117
GLU A 120
LEU A 121
LEU A  79
LEU A 150
None
0.95A 1errB-3rk6A:
undetectable
1errB-3rk6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B


(Homo sapiens)
PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
5 ALA A 121
LEU A 143
LEU A  78
LEU A  67
LEU A  65
None
1.08A 1errB-3vgoA:
undetectable
1errB-3vgoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B


(Homo sapiens)
PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
5 ALA A 121
LEU A 146
LEU A  78
LEU A  67
LEU A  65
None
0.86A 1errB-3vgoA:
undetectable
1errB-3vgoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
5 LEU A 152
LEU A 221
ILE A 203
LEU A 194
LEU A 186
None
0.87A 1errB-3w1gA:
undetectable
1errB-3w1gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zco REGULATORY PROTEIN
SIR3


(Saccharomyces
cerevisiae)
no annotation 5 ALA A 902
GLU A 905
LEU A 860
ILE A 855
LEU A 923
None
1.00A 1errB-3zcoA:
undetectable
1errB-3zcoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN


(Burkholderia
pseudomallei)
PF00496
(SBP_bac_5)
5 ALA A 328
LEU A 329
LEU A 385
LEU A 320
LEU A 313
None
1.12A 1errB-3zs6A:
undetectable
1errB-3zs6A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1


(Saccharomyces
cerevisiae)
PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn)
5 ALA A 112
TRP A 288
LEU A 293
LEU A 313
LEU A 284
None
1.02A 1errB-4a9aA:
undetectable
1errB-4a9aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli)
PF06872
(EspG)
5 LEU A  58
LEU A 131
LEU A 130
LEU A  82
LEU A  79
None
1.19A 1errB-4fmcA:
undetectable
1errB-4fmcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwv TTC1975 PEPTIDASE

(Meiothermus
taiwanensis)
PF13654
(AAA_32)
5 GLU A  98
LEU A  79
LEU A 255
LEU A 228
LEU A 217
None
1.11A 1errB-4fwvA:
undetectable
1errB-4fwvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV


(Borreliella
burgdorferi)
PF00496
(SBP_bac_5)
5 ALA A 309
LEU A 310
LEU A 359
LEU A 301
LEU A 294
None
1.23A 1errB-4gl8A:
undetectable
1errB-4gl8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans)
PF00202
(Aminotran_3)
5 ALA A 383
GLU A 382
LEU A 381
ARG A 186
LEU A 441
None
1.01A 1errB-4grxA:
undetectable
1errB-4grxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens)
PF04675
(DNA_ligase_A_N)
5 LEU A 152
LEU A 221
ILE A 203
LEU A 194
LEU A 186
None
1.03A 1errB-4htpA:
undetectable
1errB-4htpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 5 ALA D 272
LEU D 276
TRP D 305
ARG D 316
ILE D 428
None
1.01A 1errB-4j5xD:
22.7
1errB-4j5xD:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1


(Homo sapiens)
no annotation 5 ALA D 272
TRP D 305
LEU D 309
ARG D 316
ILE D 428
None
0.91A 1errB-4j5xD:
22.7
1errB-4j5xD:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ALA A 386
LEU A 388
LEU A  15
LEU A 357
LEU A 406
None
1.13A 1errB-4mv3A:
undetectable
1errB-4mv3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
vivax)
PF13649
(Methyltransf_25)
5 THR A  41
ALA A  40
LEU A 210
LEU A 213
ILE A  27
None
1.04A 1errB-4mwzA:
undetectable
1errB-4mwzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
vivax)
PF13649
(Methyltransf_25)
5 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
None
1.22A 1errB-4mwzA:
undetectable
1errB-4mwzA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
6 ALA A 287
GLU A 290
LEU A 291
TRP A 320
LEU A 324
ARG A 331
None
0.50A 1errB-4n1yA:
26.9
1errB-4n1yA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n77 UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
PF09704
(Cas_Cas5d)
5 ALA A 178
LEU A   5
LEU A 170
LEU A 196
LEU A 229
None
1.17A 1errB-4n77A:
undetectable
1errB-4n77A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT


(Escherichia
coli;
Mus musculus)
PF00104
(Hormone_recep)
PF13416
(SBP_bac_8)
6 LEU A1091
LEU A1098
LEU A1101
LEU A1076
LEU A1257
LEU A1259
None
1.42A 1errB-4nufA:
12.4
1errB-4nufA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phq HEMOLYSIN E,
CHROMOSOMAL


(Escherichia
coli)
PF06109
(HlyE)
5 THR A  19
ALA A  23
LEU A  24
TRP A  86
LEU A 127
None
1.19A 1errB-4phqA:
undetectable
1errB-4phqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12)
PF00756
(Esterase)
6 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
None
1.41A 1errB-4rgyA:
undetectable
1errB-4rgyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 773
TRP A 806
LEU A 810
LEU A 814
ARG A 817
CV7  A1987 (-3.5A)
None
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
0.47A 1errB-4udbA:
23.9
1errB-4udbA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B


(Homo sapiens)
PF00233
(PDEase_I)
5 TRP A 348
LEU A 421
LEU A 422
ILE A 371
LEU A 645
None
1.15A 1errB-4wziA:
undetectable
1errB-4wziA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
PF16919
(PknG_rubred)
5 THR A 330
LEU A 335
ILE A 210
LEU A 264
LEU A 369
None
1.16A 1errB-4y0xA:
undetectable
1errB-4y0xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
PF16919
(PknG_rubred)
5 THR A 330
LEU A 335
ILE A 210
LEU A 264
LEU A 392
None
1.06A 1errB-4y0xA:
undetectable
1errB-4y0xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
6 THR A1281
ALA A1282
LEU A1256
LEU A1257
LEU A1341
LEU A1729
None
1.36A 1errB-5amqA:
undetectable
1errB-5amqA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV


(Burkholderia
cenocepacia)
PF00005
(ABC_tran)
5 ALA C 223
LEU C 195
ILE C 249
LEU C  33
LEU C 179
None
1.19A 1errB-5b57C:
undetectable
1errB-5b57C:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO


(Photobacterium
angustum)
PF00158
(Sigma54_activat)
5 GLU A 208
LEU A 211
LEU A 250
LEU A 299
LEU A 238
None
1.16A 1errB-5ep1A:
undetectable
1errB-5ep1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 THR A 211
ALA A 214
GLU A 217
ARG A  95
LEU A 195
None
0.83A 1errB-5iq0A:
undetectable
1errB-5iq0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE


(Pseudomonas)
PF00202
(Aminotran_3)
5 THR A  92
ALA A  94
GLU A  97
LEU A  98
LEU A 297
None
0.98A 1errB-5kqwA:
undetectable
1errB-5kqwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muw PACKAGING ENZYME P4

(Pseudomonas
virus phi6)
PF11602
(NTPase_P4)
5 THR A  43
ALA A  47
GLU A  50
LEU A 177
LEU A 180
None
1.21A 1errB-5muwA:
undetectable
1errB-5muwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT


(Methanotorris
formicicus)
PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
5 THR A 380
LEU C 235
LEU C 234
ILE C 241
LEU A 431
None
1.14A 1errB-5n28A:
undetectable
1errB-5n28A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv8 EF-P ARGININE 32
RHAMNOSYL-TRANSFERAS
E


(Pseudomonas
putida)
PF10093
(DUF2331)
5 TRP A 338
LEU A 324
LEU A 321
LEU A 205
LEU A 202
None
1.05A 1errB-5nv8A:
undetectable
1errB-5nv8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE


(Leishmania
major)
no annotation 5 THR A 307
LEU A 259
ILE A 194
LEU A 310
LEU A  58
None
1.19A 1errB-5nzgA:
undetectable
1errB-5nzgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN


(Mycolicibacterium
smegmatis)
no annotation 5 GLU B 206
LEU B 203
LEU B 163
LEU B 185
LEU B 137
None
0.97A 1errB-5op0B:
undetectable
1errB-5op0B:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
7 ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
ILE A 376
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
0.50A 1errB-5toaA:
29.6
1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
5 ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 476
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 (-3.5A)
0.66A 1errB-5toaA:
29.6
1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
LEU A 495
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
1.14A 1errB-5toaA:
29.6
1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
7 THR A 299
ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
0.41A 1errB-5toaA:
29.6
1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA


(Homo sapiens)
PF00104
(Hormone_recep)
6 THR A 299
GLU A 305
LEU A 306
TRP A 335
LEU A 343
ARG A 346
None
EST  A 601 (-2.4A)
None
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
0.66A 1errB-5toaA:
29.6
1errB-5toaA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3e TRANSCRIPTIONAL
REGULATOR


(Porphyromonas
gingivalis)
no annotation 5 ALA A  65
GLU A  66
LEU A 110
LEU A  52
LEU A  90
GOL  A 201 (-3.7A)
None
None
None
None
0.86A 1errB-5v3eA:
undetectable
1errB-5v3eA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)


(Helicobacter
pylori)
no annotation 5 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
None
1.02A 1errB-5wbfA:
undetectable
1errB-5wbfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5


(Aquareovirus C)
no annotation 5 THR B 442
LEU B 351
LEU B 349
ILE B 307
LEU B 358
None
1.09A 1errB-5zvtB:
undetectable
1errB-5zvtB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta)
no annotation 5 THR A 113
ALA A 112
LEU A 134
ILE A  44
LEU A  60
None
1.14A 1errB-6bk5A:
undetectable
1errB-6bk5A:
17.09