SIMILAR PATTERNS OF AMINO ACIDS FOR 1ERR_B_RALB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4a ARGININE REPRESSOR

(Geobacillus
stearothermophilus) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		5 LEU A  94
LEU A  93
ILE A 122
LEU A  80
LEU A 149
 None
 1.21A 1errB-1b4aA:
undetectable		 1errB-1b4aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 LEU A 177
LEU A 182
ILE A 188
LEU A 491
LEU A 494
 None
 1.15A 1errB-1ebvA:
undetectable		 1errB-1ebvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 LEU 1 355
LEU 1 356
ILE 1 349
LEU 1 287
LEU 1 188
 None
 1.19A 1errB-1gt91:
undetectable		 1errB-1gt91:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		6 TRP A 318
LEU A 322
ILE A 385
LEU A 476
LEU A 487
LEU A 490
 None
LPP  A   1 ( 4.8A)
None
LPP  A   1 (-4.2A)
None
None
 0.89A 1errB-1hg4A:
24.1		 1errB-1hg4A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 TRP A 667
LEU A  23
ILE A  81
LEU A 614
LEU A 671
 None
 1.20A 1errB-1j1wA:
undetectable		 1errB-1j1wA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 GLU A 333
LEU A 332
LEU A 287
LEU A 359
LEU A 356
 None
 1.16A 1errB-1nneA:
undetectable		 1errB-1nneA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 TRP A 110
LEU A 118
ILE A 151
LEU A 159
LEU A 108
 None
 1.15A 1errB-1oltA:
undetectable		 1errB-1oltA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
LEU A 525
 EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
 0.59A 1errB-1pcgA:
32.2		 1errB-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
 None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
 0.29A 1errB-1pcgA:
32.2		 1errB-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 THR A 347
GLU A 353
LEU A 354
TRP A 383
ARG A 394
 None
EST  A   1 (-2.8A)
None
None
EST  A   1 (-3.7A)
 0.57A 1errB-1pcgA:
32.2		 1errB-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans) 		no annotation 5 ALA A 347
GLU A 350
LEU A 318
ILE A 286
LEU A 374
 None
 1.19A 1errB-1pgvA:
undetectable		 1errB-1pgvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 THR A1264
ALA A1317
LEU A1253
LEU A1230
LEU A1287
 None
 1.21A 1errB-1s16A:
undetectable		 1errB-1s16A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 665
LEU A 532
ILE A 691
LEU A 292
LEU A 711
 None
 1.14A 1errB-1t6pA:
undetectable		 1errB-1t6pA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlq HYPOTHETICAL PROTEIN
YPJQ

(Bacillus
subtilis) 		PF04608
(PgpA) 		5 ALA A 149
LEU A 150
LEU A 104
ILE A  98
LEU A  19
 None
 1.05A 1errB-1tlqA:
undetectable		 1errB-1tlqA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 THR A 163
ALA A 166
GLU A 169
LEU A 170
LEU A  95
 None
None
None
None
4PA  A 701 (-4.2A)
 1.06A 1errB-1tqhA:
undetectable		 1errB-1tqhA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 343
TRP A 376
LEU A 380
ARG A 387
ILE A 499
 MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
None
 0.98A 1errB-1uhlA:
22.5		 1errB-1uhlA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		5 ALA A  68
GLU A  71
LEU A  72
LEU A 231
LEU A 241
 None
 0.96A 1errB-2bcoA:
undetectable		 1errB-2bcoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ALA A 403
GLU A 433
LEU A 404
LEU A  41
LEU A  91
 None
 1.21A 1errB-2e4uA:
undetectable		 1errB-2e4uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A 366
LEU A 373
LEU A 445
LEU A 431
LEU A 390
 None
 1.21A 1errB-2eu9A:
undetectable		 1errB-2eu9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fq1 ISOCHORISMATASE

(Escherichia
coli) 		PF00550
(PP-binding)
PF00857
(Isochorismatase) 		5 ALA A 177
LEU A 178
ILE A  72
LEU A 206
LEU A 190
 None
 1.14A 1errB-2fq1A:
undetectable		 1errB-2fq1A:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
GLU A 275
TRP A 305
LEU A 309
ARG A 316
 OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
None
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
 0.52A 1errB-2gpvA:
26.0		 1errB-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran) 		5 THR A 191
LEU A 157
LEU A  46
ILE A 212
LEU A 176
 None
 1.18A 1errB-2it1A:
undetectable		 1errB-2it1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 HYPOTHETICAL PROTEIN
YPL007C

(Saccharomyces
cerevisiae) 		PF12660
(zf-TFIIIC) 		5 ALA A 462
LEU A 458
LEU A 475
LEU A 427
LEU A 430
 None
 0.87A 1errB-2j04A:
undetectable		 1errB-2j04A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3q TUSP1

(Nephila
antipodiana) 		PF16763
(Spidroin_N) 		5 ALA A  11
LEU A  10
LEU A  33
LEU A  87
LEU A  91
 None
 1.08A 1errB-2k3qA:
undetectable		 1errB-2k3qA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 THR A 248
LEU A 104
LEU A 101
LEU A 163
LEU A 159
 None
 1.23A 1errB-2o1wA:
undetectable		 1errB-2o1wA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 525
 EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-3.6A)
 0.76A 1errB-2ocfA:
31.1		 1errB-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 THR A 347
ALA A 350
GLU A 353
TRP A 383
LEU A 387
LEU A 391
ARG A 394
ILE A 424
 None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
 0.66A 1errB-2ocfA:
31.1		 1errB-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 THR A 347
GLU A 353
LEU A 354
TRP A 383
LEU A 391
ARG A 394
 None
EST  A 596 (-2.7A)
None
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
 0.70A 1errB-2ocfA:
31.1		 1errB-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql2 NEUROGENIC
DIFFERENTIATION
FACTOR 1
TRANSCRIPTION FACTOR
E2-ALPHA

(Mus musculus) 		PF00010
(HLH) 		5 ALA A 561
GLU A 564
LEU A 565
LEU B 124
LEU A 585
 None
 1.00A 1errB-2ql2A:
undetectable		 1errB-2ql2A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9

(Homo sapiens) 		PF06821
(Ser_hydrolase) 		5 ALA A  92
LEU A 181
LEU A 182
ILE A 175
LEU A 153
 None
 1.18A 1errB-2qs9A:
undetectable		 1errB-2qs9A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF04198
(Sugar-bind) 		5 ALA A 100
LEU A 104
LEU A 281
ILE A 213
LEU A 164
 None
 0.97A 1errB-2r5fA:
undetectable		 1errB-2r5fA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vec PIRIN-LIKE PROTEIN
YHAK

(Escherichia
coli) 		PF02678
(Pirin) 		5 LEU A  91
LEU A  92
ILE A 143
LEU A 112
LEU A  48
 None
 1.19A 1errB-2vecA:
undetectable		 1errB-2vecA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus) 		PF06745
(ATPase) 		5 ALA A 134
LEU A 135
LEU A  91
ILE A  66
LEU A 150
 None
 0.99A 1errB-2w0mA:
undetectable		 1errB-2w0mA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 THR A 193
ALA A 196
LEU A 200
LEU A 210
LEU A 102
 None
 0.81A 1errB-2w8sA:
undetectable		 1errB-2w8sA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		5 ALA A 125
LEU A 127
LEU A  57
ARG A 353
LEU A  71
 None
 1.24A 1errB-2wbpA:
undetectable		 1errB-2wbpA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 424
TRP A 423
LEU A 409
ILE A 154
LEU A 455
 None
 1.15A 1errB-2x0qA:
undetectable		 1errB-2x0qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1

(Homo sapiens) 		PF09770
(PAT1) 		5 THR A 616
ALA A 617
LEU A 659
LEU A 644
LEU A 647
 None
 1.12A 1errB-2xesA:
undetectable		 1errB-2xesA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypb T-CELL ACUTE
LYMPHOCYTIC LEUKEMIA
PROTEIN 1
TRANSCRIPTION FACTOR
E2-ALPHA

(Homo sapiens) 		PF00010
(HLH) 		5 ALA A 206
GLU A 209
LEU A 210
LEU B 569
LEU A 229
 None
 1.04A 1errB-2ypbA:
undetectable		 1errB-2ypbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypb T-CELL ACUTE
LYMPHOCYTIC LEUKEMIA
PROTEIN 1
TRANSCRIPTION FACTOR
E2-ALPHA

(Homo sapiens) 		PF00010
(HLH) 		5 ALA B 565
GLU B 568
LEU B 569
LEU A 210
LEU B 589
 None
 0.97A 1errB-2ypbB:
undetectable		 1errB-2ypbB:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ALA A 256
GLU A 260
LEU A 257
LEU A 109
LEU A 268
 None
 0.89A 1errB-2ys6A:
undetectable		 1errB-2ys6A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		5 LEU A  90
ILE A 187
LEU A 145
LEU A  76
LEU A 315
 None
 1.00A 1errB-2zbmA:
undetectable		 1errB-2zbmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 ALA A  89
GLU A  90
LEU A  88
LEU A 275
LEU A 269
 None
 1.20A 1errB-2zukA:
undetectable		 1errB-2zukA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		5 LEU A 111
ILE A  66
LEU A  31
LEU A  37
LEU A  40
 None
 1.23A 1errB-3bm3A:
undetectable		 1errB-3bm3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 GLU C 356
LEU C 355
ILE C  52
LEU C 317
LEU C 314
 None
 1.06A 1errB-3degC:
undetectable		 1errB-3degC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ILE A 428
 9CR  A7223 (-4.2A)
None
None
9CR  A7223 ( 4.4A)
None
 0.87A 1errB-3dzuA:
22.1		 1errB-3dzuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE

(Neisseria
meningitidis) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		5 THR A 154
ALA A 133
GLU A 128
LEU A 132
ILE A  20
 None
 1.21A 1errB-3eagA:
undetectable		 1errB-3eagA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc2 O-SUCCINYLBENZOATE
SYNTHASE

(Salmonella
enterica) 		PF13378
(MR_MLE_C) 		5 ALA A  90
LEU A  91
LEU A  34
LEU A  63
LEU A  77
 None
 1.22A 1errB-3gc2A:
undetectable		 1errB-3gc2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 LEU A  40
ILE A 150
LEU A 120
LEU A  52
LEU A  49
 None
 1.20A 1errB-3h3bA:
undetectable		 1errB-3h3bA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 ALA A 155
LEU A 158
ILE A  79
LEU A  55
LEU A  59
 None
 1.17A 1errB-3h6eA:
undetectable		 1errB-3h6eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Leptospira
interrogans) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ALA A 134
LEU A 136
LEU A 169
LEU A 142
LEU A 124
 None
 0.98A 1errB-3i3aA:
undetectable		 1errB-3i3aA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Leptospira
interrogans) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 THR A 131
ALA A 134
LEU A 136
LEU A 142
LEU A 124
 None
 1.06A 1errB-3i3aA:
undetectable		 1errB-3i3aA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Saccharomyces
cerevisiae) 		PF05916
(Sld5) 		5 GLU B  97
LEU B  93
LEU B  98
ILE B 151
LEU B 126
 None
 1.12A 1errB-3jc7B:
undetectable		 1errB-3jc7B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jw4 TRANSCRIPTIONAL
REGULATOR, MARR/EMRR
FAMILY

(Clostridium
acetobutylicum) 		PF01047
(MarR) 		5 ALA A 106
GLU A 109
LEU A 107
LEU A  34
LEU A  36
 None
 1.23A 1errB-3jw4A:
undetectable		 1errB-3jw4A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 293
ILE A  92
LEU A 119
LEU A 187
LEU A 226
 None
 1.12A 1errB-3k96A:
undetectable		 1errB-3k96A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfq TRANSCRIPTION FACTOR
IWS1

(Saccharomyces
cerevisiae) 		PF08711
(Med26) 		5 ALA A 105
LEU A 106
LEU A  63
LEU A  56
LEU A  85
 None
 1.19A 1errB-3nfqA:
undetectable		 1errB-3nfqA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		5 ALA A 117
GLU A 120
LEU A 121
LEU A  79
LEU A 150
 None
 0.95A 1errB-3rk6A:
undetectable		 1errB-3rk6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		5 ALA A 121
LEU A 143
LEU A  78
LEU A  67
LEU A  65
 None
 1.08A 1errB-3vgoA:
undetectable		 1errB-3vgoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		5 ALA A 121
LEU A 146
LEU A  78
LEU A  67
LEU A  65
 None
 0.86A 1errB-3vgoA:
undetectable		 1errB-3vgoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LEU A 152
LEU A 221
ILE A 203
LEU A 194
LEU A 186
 None
 0.87A 1errB-3w1gA:
undetectable		 1errB-3w1gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zco REGULATORY PROTEIN
SIR3

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 902
GLU A 905
LEU A 860
ILE A 855
LEU A 923
 None
 1.00A 1errB-3zcoA:
undetectable		 1errB-3zcoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		5 ALA A 328
LEU A 329
LEU A 385
LEU A 320
LEU A 313
 None
 1.12A 1errB-3zs6A:
undetectable		 1errB-3zs6A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 ALA A 112
TRP A 288
LEU A 293
LEU A 313
LEU A 284
 None
 1.02A 1errB-4a9aA:
undetectable		 1errB-4a9aA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		5 LEU A  58
LEU A 131
LEU A 130
LEU A  82
LEU A  79
 None
 1.19A 1errB-4fmcA:
undetectable		 1errB-4fmcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwv TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF13654
(AAA_32) 		5 GLU A  98
LEU A  79
LEU A 255
LEU A 228
LEU A 217
 None
 1.11A 1errB-4fwvA:
undetectable		 1errB-4fwvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV

(Borreliella
burgdorferi) 		PF00496
(SBP_bac_5) 		5 ALA A 309
LEU A 310
LEU A 359
LEU A 301
LEU A 294
 None
 1.23A 1errB-4gl8A:
undetectable		 1errB-4gl8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		5 ALA A 383
GLU A 382
LEU A 381
ARG A 186
LEU A 441
 None
 1.01A 1errB-4grxA:
undetectable		 1errB-4grxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens) 		PF04675
(DNA_ligase_A_N) 		5 LEU A 152
LEU A 221
ILE A 203
LEU A 194
LEU A 186
 None
 1.03A 1errB-4htpA:
undetectable		 1errB-4htpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 5 ALA D 272
LEU D 276
TRP D 305
ARG D 316
ILE D 428
 None
 1.01A 1errB-4j5xD:
22.7		 1errB-4j5xD:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 5 ALA D 272
TRP D 305
LEU D 309
ARG D 316
ILE D 428
 None
 0.91A 1errB-4j5xD:
22.7		 1errB-4j5xD:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mv3 BIOTIN CARBOXYLASE

(Haemophilus
influenzae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A 386
LEU A 388
LEU A  15
LEU A 357
LEU A 406
 None
 1.13A 1errB-4mv3A:
undetectable		 1errB-4mv3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		5 THR A  41
ALA A  40
LEU A 210
LEU A 213
ILE A  27
 None
 1.04A 1errB-4mwzA:
undetectable		 1errB-4mwzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		5 THR A  41
ALA A  40
TRP A 255
LEU A 210
LEU A 213
 None
 1.22A 1errB-4mwzA:
undetectable		 1errB-4mwzA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 ALA A 287
GLU A 290
LEU A 291
TRP A 320
LEU A 324
ARG A 331
 None
 0.50A 1errB-4n1yA:
26.9		 1errB-4n1yA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n77 UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF09704
(Cas_Cas5d) 		5 ALA A 178
LEU A   5
LEU A 170
LEU A 196
LEU A 229
 None
 1.17A 1errB-4n77A:
undetectable		 1errB-4n77A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		6 LEU A1091
LEU A1098
LEU A1101
LEU A1076
LEU A1257
LEU A1259
 None
 1.42A 1errB-4nufA:
12.4		 1errB-4nufA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phq HEMOLYSIN E,
CHROMOSOMAL

(Escherichia
coli) 		PF06109
(HlyE) 		5 THR A  19
ALA A  23
LEU A  24
TRP A  86
LEU A 127
 None
 1.19A 1errB-4phqA:
undetectable		 1errB-4phqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		6 ALA A 131
LEU A 134
LEU A  48
LEU A 124
ILE A  64
LEU A  45
 None
 1.41A 1errB-4rgyA:
undetectable		 1errB-4rgyA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 773
TRP A 806
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 (-3.5A)
None
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.47A 1errB-4udbA:
23.9		 1errB-4udbA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TRP A 348
LEU A 421
LEU A 422
ILE A 371
LEU A 645
 None
 1.15A 1errB-4wziA:
undetectable		 1errB-4wziA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		5 THR A 330
LEU A 335
ILE A 210
LEU A 264
LEU A 369
 None
 1.16A 1errB-4y0xA:
undetectable		 1errB-4y0xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		5 THR A 330
LEU A 335
ILE A 210
LEU A 264
LEU A 392
 None
 1.06A 1errB-4y0xA:
undetectable		 1errB-4y0xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		6 THR A1281
ALA A1282
LEU A1256
LEU A1257
LEU A1341
LEU A1729
 None
 1.36A 1errB-5amqA:
undetectable		 1errB-5amqA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		5 ALA C 223
LEU C 195
ILE C 249
LEU C  33
LEU C 179
 None
 1.19A 1errB-5b57C:
undetectable		 1errB-5b57C:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep1 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00158
(Sigma54_activat) 		5 GLU A 208
LEU A 211
LEU A 250
LEU A 299
LEU A 238
 None
 1.16A 1errB-5ep1A:
undetectable		 1errB-5ep1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 THR A 211
ALA A 214
GLU A 217
ARG A  95
LEU A 195
 None
 0.83A 1errB-5iq0A:
undetectable		 1errB-5iq0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqw 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		5 THR A  92
ALA A  94
GLU A  97
LEU A  98
LEU A 297
 None
 0.98A 1errB-5kqwA:
undetectable		 1errB-5kqwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muw PACKAGING ENZYME P4

(Pseudomonas
virus phi6) 		PF11602
(NTPase_P4) 		5 THR A  43
ALA A  47
GLU A  50
LEU A 177
LEU A 180
 None
 1.21A 1errB-5muwA:
undetectable		 1errB-5muwA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus) 		PF02240
(MCR_gamma)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 THR A 380
LEU C 235
LEU C 234
ILE C 241
LEU A 431
 None
 1.14A 1errB-5n28A:
undetectable		 1errB-5n28A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv8 EF-P ARGININE 32
RHAMNOSYL-TRANSFERAS
E

(Pseudomonas
putida) 		PF10093
(DUF2331) 		5 TRP A 338
LEU A 324
LEU A 321
LEU A 205
LEU A 202
 None
 1.05A 1errB-5nv8A:
undetectable		 1errB-5nv8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 5 THR A 307
LEU A 259
ILE A 194
LEU A 310
LEU A  58
 None
 1.19A 1errB-5nzgA:
undetectable		 1errB-5nzgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLU B 206
LEU B 203
LEU B 163
LEU B 185
LEU B 137
 None
 0.97A 1errB-5op0B:
undetectable		 1errB-5op0B:
17.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
ILE A 376
 EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
 0.50A 1errB-5toaA:
29.6		 1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 476
 EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 (-3.5A)
 0.66A 1errB-5toaA:
29.6		 1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
LEU A 495
 EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
 1.14A 1errB-5toaA:
29.6		 1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 THR A 299
ALA A 302
GLU A 305
TRP A 335
LEU A 339
LEU A 343
ARG A 346
 None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 0.41A 1errB-5toaA:
29.6		 1errB-5toaA:
57.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 THR A 299
GLU A 305
LEU A 306
TRP A 335
LEU A 343
ARG A 346
 None
EST  A 601 (-2.4A)
None
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 0.66A 1errB-5toaA:
29.6		 1errB-5toaA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3e TRANSCRIPTIONAL
REGULATOR

(Porphyromonas
gingivalis) 		no annotation 5 ALA A  65
GLU A  66
LEU A 110
LEU A  52
LEU A  90
 GOL  A 201 (-3.7A)
None
None
None
None
 0.86A 1errB-5v3eA:
undetectable		 1errB-5v3eA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 ALA A 117
LEU A 102
LEU A  94
LEU A  95
LEU A  70
 None
 1.02A 1errB-5wbfA:
undetectable		 1errB-5wbfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 THR B 442
LEU B 351
LEU B 349
ILE B 307
LEU B 358
 None
 1.09A 1errB-5zvtB:
undetectable		 1errB-5zvtB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 5 THR A 113
ALA A 112
LEU A 134
ILE A  44
LEU A  60
 None
 1.14A 1errB-6bk5A:
undetectable		 1errB-6bk5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT
[NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU B 121
ASP B 125
LEU B 206
HIS A  45
 None
 1.23A 1errB-1e3dB:
undetectable		 1errB-1e3dB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 142
MET A 207
LEU A 189
HIS A 244
 None
COA  A1350 (-2.9A)
COA  A1350 ( 4.8A)
COA  A1350 (-4.4A)
 1.12A 1errB-1eblA:
0.0		 1errB-1eblA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 LEU A 393
MET A 276
LEU A 283
HIS A 280
 None
 1.21A 1errB-1gpmA:
0.0		 1errB-1gpmA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ASP A 409
MET A 264
LEU A 225
HIS A  90
 None
None
None
ZN  A1102 ( 3.3A)
 0.99A 1errB-1hwwA:
0.0		 1errB-1hwwA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT
II

(Salmonella
enterica) 		PF00117
(GATase) 		4 LEU B 143
ASP B 159
LEU B  70
HIS B  86
 None
 1.24A 1errB-1i1qB:
0.0		 1errB-1i1qB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		4 LEU B 146
ASP B 162
LEU B  72
HIS B  88
 None
 1.14A 1errB-1i7qB:
0.0		 1errB-1i7qB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.10A 1errB-1lkdA:
undetectable		 1errB-1lkdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.14A 1errB-1lpfA:
undetectable		 1errB-1lpfA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrv LEUCINE-RICH REPEAT
VARIANT

(Azotobacter
vinelandii) 		PF01816
(LRV)
PF05484
(LRV_FeS) 		4 LEU A 212
ASP A 207
LEU A 223
HIS A 217
 None
 1.18A 1errB-1lrvA:
undetectable		 1errB-1lrvA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
MET A 388
MET A 421
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
None
EST  A   1 ( 4.3A)
None
EST  A   1 (-3.8A)
 0.59A 1errB-1pcgA:
32.2		 1errB-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 193
MET A 198
MET A 261
LEU A 249
 None
 1.23A 1errB-1pm2A:
2.6		 1errB-1pm2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 LEU A 101
ASP A  22
MET A 285
LEU A  93
 None
 1.18A 1errB-1qpoA:
undetectable		 1errB-1qpoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8i TRAC

(Escherichia
coli) 		PF07996
(T4SS) 		4 LEU A  41
ASP A 172
MET A 160
LEU A  48
 None
 1.19A 1errB-1r8iA:
1.7		 1errB-1r8iA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		4 LEU A  47
ASP A 101
LEU A   9
HIS A 120
 None
None
None
CU  A 155 (-3.0A)
 1.04A 1errB-1srdA:
undetectable		 1errB-1srdA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 LEU B 113
ASP B 117
MET B  45
HIS B  60
 None
 0.81A 1errB-1sxjB:
undetectable		 1errB-1sxjB:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Deinococcus
radiodurans) 		PF02566
(OsmC) 		4 LEU B 105
MET B 114
LEU B  62
HIS B 101
 None
None
None
GOL  B1140 (-4.2A)
 1.12A 1errB-1uspB:
undetectable		 1errB-1uspB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqy HYPOTHETICAL PROTEIN
AGR_PAT_315

(Agrobacterium
fabrum) 		PF07978
(NIPSNAP) 		4 LEU A  83
MET A  15
LEU A  19
HIS A  53
 None
 1.14A 1errB-1vqyA:
undetectable		 1errB-1vqyA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		4 LEU A 126
ASP A 121
MET A  52
LEU A  56
 None
 1.26A 1errB-1xqpA:
undetectable		 1errB-1xqpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		4 LEU A 235
ASP A 197
MET A 273
LEU A 280
 None
 0.96A 1errB-1xqsA:
undetectable		 1errB-1xqsA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1

(Homo sapiens) 		PF01112
(Asparaginase_2) 		4 LEU A 310
ASP A 314
MET A 323
LEU A 302
 None
 1.26A 1errB-2a8iA:
undetectable		 1errB-2a8iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 LEU A 244
ASP A 235
MET A 326
LEU A 318
 None
 1.22A 1errB-2abjA:
undetectable		 1errB-2abjA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4a BH3024

(Bacillus
halodurans) 		PF00072
(Response_reg) 		4 LEU A 100
ASP A  56
LEU A  23
HIS A 116
 None
 0.99A 1errB-2b4aA:
undetectable		 1errB-2b4aA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 LEU A 203
ASP A 256
MET A 195
LEU A 271
 None
 1.21A 1errB-2c1cA:
undetectable		 1errB-2c1cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		4 LEU A  70
ASP A 165
LEU A 102
HIS A  49
 None
 1.26A 1errB-2cybA:
undetectable		 1errB-2cybA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4z TGTWINSCAN_2721 - E2
DOMAIN

(Toxoplasma
gondii) 		PF00179
(UQ_con) 		4 LEU A 148
MET A 154
MET A 111
LEU A 131
 None
 1.18A 1errB-2f4zA:
undetectable		 1errB-2f4zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		4 LEU A 123
ASP A 191
MET A 174
LEU A 176
 None
 1.18A 1errB-2f8lA:
undetectable		 1errB-2f8lA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		4 LEU A  63
ASP A 100
MET A  50
LEU A  75
 None
 1.17A 1errB-2iuyA:
undetectable		 1errB-2iuyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		4 LEU A 388
ASP A 391
LEU A 404
HIS A 314
 None
 1.06A 1errB-2jg7A:
undetectable		 1errB-2jg7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb2 BLRP1

(Klebsiella
pneumoniae) 		PF04940
(BLUF) 		4 LEU A  43
ASP A  99
LEU A  80
HIS A  74
 FMN  A 149 ( 4.3A)
None
None
FMN  A 149 ( 3.6A)
 1.14A 1errB-2kb2A:
undetectable		 1errB-2kb2A:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
MET A 388
MET A 421
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
None
EST  A 596 (-4.5A)
None
EST  A 596 (-4.2A)
 0.64A 1errB-2ocfA:
31.1		 1errB-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		4 LEU A  40
ASP A 178
MET A  70
LEU A  79
 None
 1.19A 1errB-2ozeA:
undetectable		 1errB-2ozeA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 LEU A 201
ASP A 214
MET A  66
LEU A  94
 None
None
None
SAH  A 301 ( 4.9A)
 1.22A 1errB-2pbfA:
undetectable		 1errB-2pbfA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		4 LEU A  80
MET A 101
LEU A 112
HIS A 168
 None
 1.27A 1errB-2pbxA:
undetectable		 1errB-2pbxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 178
ASP A 174
MET A 239
LEU A 186
 None
 1.18A 1errB-2pwhA:
undetectable		 1errB-2pwhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind)
PF09228
(Prok-TraM) 		4 LEU A 161
ASP C  72
MET A 128
LEU A 154
 None
 1.10A 1errB-2q0oA:
undetectable		 1errB-2q0oA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A 233
ASP A 226
LEU A 258
HIS A 201
 None
 1.15A 1errB-2rfaA:
undetectable		 1errB-2rfaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 LEU A 450
ASP A 561
MET A 378
LEU A 577
 None
 1.25A 1errB-2v9pA:
undetectable		 1errB-2v9pA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 490
ASP A 688
MET A 193
LEU A 189
 None
 1.22A 1errB-2xf2A:
undetectable		 1errB-2xf2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 LEU A  48
ASP A  31
LEU A  67
HIS A  22
 None
None
HEM  A 350 ( 4.8A)
None
 0.87A 1errB-2yp1A:
undetectable		 1errB-2yp1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257

(Methanocaldococcus
jannaschii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 LEU A 100
ASP A  18
MET A 108
LEU A 126
 None
 1.12A 1errB-2z2uA:
undetectable		 1errB-2z2uA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
ASP A 182
MET A  93
HIS A  64
 HTL  A 827 (-3.9A)
MG  A 826 ( 2.8A)
None
HTL  A 827 (-4.3A)
 1.24A 1errB-3ahiA:
undetectable		 1errB-3ahiA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 LEU A 157
ASP A 182
MET A  93
HIS A  64
 TPP  A 900 (-4.0A)
CA  A 901 ( 3.0A)
None
None
 1.26A 1errB-3ai7A:
undetectable		 1errB-3ai7A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		4 LEU A 299
ASP A 247
LEU A 279
HIS A 346
 None
 1.16A 1errB-3cwvA:
undetectable		 1errB-3cwvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 LEU A 241
ASP A 351
MET A 302
LEU A 273
 None
 1.20A 1errB-3d3lA:
undetectable		 1errB-3d3lA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		4 LEU A 205
ASP A 226
LEU A 198
HIS A 263
 None
 1.04A 1errB-3gzsA:
undetectable		 1errB-3gzsA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdl ROYAL PALM TREE
PEROXIDASE

(Roystonea regia) 		PF00141
(peroxidase) 		4 LEU A  55
ASP A  66
MET A  39
LEU A 101
 None
 1.14A 1errB-3hdlA:
undetectable		 1errB-3hdlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 142
MET A 201
LEU A 190
HIS A 238
 None
 1.25A 1errB-3il7A:
undetectable		 1errB-3il7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 LEU A   9
ASP A  14
MET A  46
HIS A  61
 None
 1.21A 1errB-3kd8A:
undetectable		 1errB-3kd8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kin KINESIN HEAVY CHAIN

(Rattus
norvegicus) 		PF00225
(Kinesin) 		4 LEU A 210
ASP A 145
MET B 284
LEU B 288
 None
 1.10A 1errB-3kinA:
undetectable		 1errB-3kinA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 414
ASP A 411
LEU A 351
HIS A 417
 None
 1.22A 1errB-3ladA:
undetectable		 1errB-3ladA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU B1111
ASP B1115
LEU B1195
HIS A  44
 None
 1.18A 1errB-3myrB:
undetectable		 1errB-3myrB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 4 ASP B 264
MET B 284
LEU B 271
HIS B 392
 None
 1.22A 1errB-3ozvB:
undetectable		 1errB-3ozvB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ASP A  23
MET A 261
LEU A 228
HIS A 298
 None
 1.18A 1errB-3pmkA:
undetectable		 1errB-3pmkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pss QNR

(Aeromonas
hydrophila) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		4 LEU A  84
ASP A  62
LEU A 133
HIS A 117
 None
 1.09A 1errB-3pssA:
undetectable		 1errB-3pssA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rof LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE PTPA

(Staphylococcus
aureus) 		PF01451
(LMWPc) 		4 ASP A  77
MET A  85
MET A  22
LEU A 107
 None
 1.15A 1errB-3rofA:
undetectable		 1errB-3rofA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 LEU A 125
ASP A 131
LEU A  20
HIS A  97
 None
 1.17A 1errB-3rysA:
undetectable		 1errB-3rysA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN

(Escherichia
coli) 		PF00374
(NiFeSe_Hases) 		4 LEU L 152
MET L 201
LEU L 194
HIS L 205
 None
 0.83A 1errB-3uscL:
undetectable		 1errB-3uscL:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 LEU A 867
ASP A 862
LEU A 840
HIS A 872
 None
 1.19A 1errB-3ux8A:
undetectable		 1errB-3ux8A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 389
MET A 435
LEU A 430
HIS A 395
 None
None
UNX  A 610 ( 4.0A)
None
 1.15A 1errB-3v8dA:
undetectable		 1errB-3v8dA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 LEU A  13
ASP A  10
MET A 285
LEU A 283
 None
 1.18A 1errB-3vcyA:
undetectable		 1errB-3vcyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 LEU A  49
ASP A  67
LEU A 183
HIS A  52
 None
 1.26A 1errB-3wibA:
undetectable		 1errB-3wibA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 LEU A 302
ASP A 304
LEU A 152
HIS A 252
 None
GOL  A 901 ( 4.4A)
None
None
 1.27A 1errB-3zk4A:
undetectable		 1errB-3zk4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		4 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.11A 1errB-4cs6A:
undetectable		 1errB-4cs6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 LEU A 265
ASP A 267
MET A 257
LEU A 370
 None
 1.01A 1errB-4fxbA:
2.1		 1errB-4fxbA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 281
ASP A 415
MET A 311
LEU A 274
 None
 1.12A 1errB-4g1pA:
undetectable		 1errB-4g1pA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI

(Caulobacter
vibrioides) 		PF06230
(DUF1009) 		4 LEU A 191
ASP A 196
LEU A 269
HIS A 235
 None
 0.76A 1errB-4j6eA:
undetectable		 1errB-4j6eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 LEU A 207
ASP A 210
MET A 266
LEU A 270
 None
 1.22A 1errB-4lx4A:
undetectable		 1errB-4lx4A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 LEU A 798
ASP A 791
LEU A 782
HIS A 889
 None
 1.22A 1errB-4n78A:
undetectable		 1errB-4n78A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE

(Escherichia
coli) 		PF02545
(Maf) 		4 LEU A  93
ASP A 131
LEU A 144
HIS A  88
 None
 0.81A 1errB-4p0eA:
undetectable		 1errB-4p0eA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 208
MET A 244
LEU A 260
HIS A 215
 None
 1.19A 1errB-4p3zA:
undetectable		 1errB-4p3zA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 LEU A 741
ASP A 743
MET A 840
LEU A 756
 None
 1.24A 1errB-4q8hA:
undetectable		 1errB-4q8hA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Rhizobium etli) 		PF01547
(SBP_bac_1) 		4 LEU A 231
ASP A 176
LEU A 413
HIS A 399
 None
 1.16A 1errB-4rk2A:
undetectable		 1errB-4rk2A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		4 LEU A  59
ASP A 113
LEU A  21
HIS A 132
 None
 1.04A 1errB-4rvpA:
undetectable		 1errB-4rvpA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU L 131
ASP L 135
LEU L 216
HIS S  45
 None
 1.14A 1errB-4u9iL:
undetectable		 1errB-4u9iL:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		4 LEU A  97
ASP A 194
MET A 257
LEU A  73
 None
PLP  A 401 (-2.8A)
None
None
 1.04A 1errB-4wbtA:
undetectable		 1errB-4wbtA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		4 LEU A 201
MET A 197
MET A 116
LEU A 192
 None
 1.23A 1errB-4x9eA:
undetectable		 1errB-4x9eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y67 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE,
APICOPLAST

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 187
MET A 195
MET A 464
LEU A 218
 None
 1.17A 1errB-4y67A:
undetectable		 1errB-4y67A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 LEU A 136
ASP A 161
MET A 175
LEU A 107
 None
 1.12A 1errB-4yryA:
undetectable		 1errB-4yryA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 LEU A 136
ASP A 162
MET A 175
LEU A 107
 None
NAD  A 503 ( 3.7A)
None
None
 0.98A 1errB-4yryA:
undetectable		 1errB-4yryA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 217
ASP A 212
LEU A 226
HIS A 222
 None
 1.09A 1errB-4z0cA:
undetectable		 1errB-4z0cA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Streptomyces
viridosporus;
Sulfolobus
solfataricus) 		no annotation 4 LEU A 254
ASP A 248
MET A 204
LEU A 135
 None
 1.12A 1errB-5b0lA:
undetectable		 1errB-5b0lA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 LEU A 237
ASP A 240
LEU A 312
HIS A 208
 None
 1.16A 1errB-5ddsA:
undetectable		 1errB-5ddsA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 LEU A 432
MET A 530
LEU A 527
HIS A 501
 None
 1.26A 1errB-5f4jA:
undetectable		 1errB-5f4jA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvj PUTATIVE
ACETYLTRANSFERASE

(Salmonella
enterica) 		PF13673
(Acetyltransf_10) 		4 LEU A  26
ASP A  28
LEU A 107
HIS A  99
 ACO  A1161 (-4.9A)
None
None
ACO  A1161 (-4.1A)
 1.13A 1errB-5fvjA:
undetectable		 1errB-5fvjA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT

(Escherichia
coli) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 LEU B  35
ASP A 100
MET A 125
HIS A 126
 None
 1.15A 1errB-5g5gB:
undetectable		 1errB-5g5gB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		4 LEU Z  94
MET Z  99
LEU Z 121
HIS Z 225
 None
 1.15A 1errB-5gmkZ:
undetectable		 1errB-5gmkZ:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 276
ASP A 282
MET A  58
LEU A 258
 None
 0.90A 1errB-5iy9A:
undetectable		 1errB-5iy9A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kia L-THREONINE
3-DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 203
ASP A 195
MET A 178
LEU A 308
 None
 1.13A 1errB-5kiaA:
undetectable		 1errB-5kiaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN
SIGNAL RECOGNITION
PARTICLE RECEPTOR
FTSY

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 LEU B 302
ASP A  38
LEU B 291
HIS B 307
 None
 1.18A 1errB-5l3sB:
undetectable		 1errB-5l3sB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin)
no annotation 		4 LEU B 942
ASP A  77
MET B 907
LEU B 893
 None
 0.96A 1errB-5lxvB:
undetectable		 1errB-5lxvB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m04 GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 LEU A 159
ASP A   5
MET A   1
LEU A 227
 None
 1.22A 1errB-5m04A:
undetectable		 1errB-5m04A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 4 LEU A 143
MET A  96
MET A  49
HIS A 108
 None
 1.26A 1errB-5m0kA:
undetectable		 1errB-5m0kA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrv CARBOXYPEPTIDASE O

(Homo sapiens) 		no annotation 4 LEU A 223
ASP A 276
MET A 215
LEU A 291
 None
 1.25A 1errB-5mrvA:
undetectable		 1errB-5mrvA:
12.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 298
MET A 340
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 ( 4.8A)
None
EST  A 601 (-4.4A)
 0.46A 1errB-5toaA:
29.6		 1errB-5toaA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 4 LEU A  73
MET A 234
LEU A  81
HIS A 231
 None
 1.25A 1errB-5y1aA:
undetectable		 1errB-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 4 LEU A 195
ASP A 200
MET A 251
LEU A 167
 None
 1.11A 1errB-5yb7A:
undetectable		 1errB-5yb7A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 LEU 2 322
ASP 2 324
MET 2 290
LEU 2 793
 None
 1.05A 1errB-5zvs2:
undetectable		 1errB-5zvs2:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk5 UBIQUITIN LIGASE CBL

(Salpingoeca
rosetta) 		no annotation 4 LEU A 134
ASP A 118
LEU A  73
HIS A 108
 None
 1.26A 1errB-6bk5A:
undetectable		 1errB-6bk5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2

(Clostridium
botulinum) 		no annotation 4 LEU A 125
ASP A 122
MET A 142
LEU A  48
 None
 1.06A 1errB-6ekvA:
undetectable		 1errB-6ekvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 131
ASP B 193
LEU B 165
HIS B 115
 None
 1.10A 1errB-6emkB:
undetectable		 1errB-6emkB:
15.81