SIMILAR PATTERNS OF AMINO ACIDS FOR 1ERR_B_CCSB381_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		3 GLU B 504
ALA B 506
SER B  84
 None
 0.65A 1errB-1a6dB:
0.1		 1errB-1a6dB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adr P22 C2 REPRESSOR

(Salmonella
virus P22) 		PF01381
(HTH_3) 		3 GLU A  39
ALA A  34
SER A  31
 None
 0.54A 1errB-1adrA:
undetectable		 1errB-1adrA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 GLU A 504
ALA A 506
SER A 544
 None
 0.71A 1errB-1d0nA:
0.0		 1errB-1d0nA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egx VASODILATOR-STIMULAT
ED PHOSPHOPROTEIN

(Homo sapiens) 		PF00568
(WH1) 		3 GLU A 114
ALA A 112
SER A 108
 None
 0.68A 1errB-1egxA:
0.0		 1errB-1egxA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		3 GLU A 221
ALA A 172
SER A 169
 None
 0.65A 1errB-1epxA:
0.0		 1errB-1epxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 GLU A 346
ALA A 344
SER A 459
 None
 0.64A 1errB-1ikpA:
0.8		 1errB-1ikpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kj9 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE 2

(Escherichia
coli) 		PF02222
(ATP-grasp) 		3 GLU A  37
ALA A  53
SER A  56
 EDO  A 401 (-2.9A)
None
MPO  A 400 (-3.8A)
 0.59A 1errB-1kj9A:
0.0		 1errB-1kj9A:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLU A 380
ALA A 382
SER A 456
 None
 0.43A 1errB-1pcgA:
32.2		 1errB-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv0 SDA

(Bacillus
subtilis) 		PF08970
(Sda) 		3 GLU A  18
ALA A  16
SER A  12
 None
 0.70A 1errB-1pv0A:
undetectable		 1errB-1pv0A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		3 GLU A 107
ALA A 116
SER A  63
 None
 0.64A 1errB-1pweA:
0.0		 1errB-1pweA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		3 GLU A 885
ALA A   5
SER A 870
 None
 0.56A 1errB-1qxpA:
0.0		 1errB-1qxpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		3 GLU A 148
ALA A 172
SER A 174
 None
 0.62A 1errB-1skaA:
undetectable		 1errB-1skaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1stu MATERNAL EFFECT
PROTEIN STAUFEN

(Drosophila
melanogaster) 		PF00035
(dsrm) 		3 GLU A  59
ALA A  57
SER A  53
 None
 0.69A 1errB-1stuA:
undetectable		 1errB-1stuA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2w SORTASE

(Staphylococcus
aureus) 		PF04203
(Sortase) 		3 GLU A 105
ALA A  92
SER A 102
 GLU  A 333 (-3.2A)
GLY  A 335 (-3.0A)
None
 0.53A 1errB-1t2wA:
undetectable		 1errB-1t2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 GLU A 248
ALA A 246
SER A 231
 None
 0.67A 1errB-1t6pA:
1.7		 1errB-1t6pA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 GLU A 369
ALA A 371
SER A 247
 None
 0.61A 1errB-1v4gA:
undetectable		 1errB-1v4gA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vct HYPOTHETICAL PROTEIN
PH0236

(Pyrococcus
horikoshii) 		PF01895
(PhoU)
PF02080
(TrkA_C) 		3 GLU A  42
ALA A  44
SER A  35
 None
 0.62A 1errB-1vctA:
undetectable		 1errB-1vctA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		3 GLU A 124
ALA A 126
SER A 216
 None
 0.61A 1errB-1xkgA:
undetectable		 1errB-1xkgA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y71 KINASE-ASSOCIATED
PROTEIN B

(Bacillus cereus) 		PF08810
(KapB) 		3 GLU A 116
ALA A 111
SER A 108
 None
 0.55A 1errB-1y71A:
undetectable		 1errB-1y71A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		3 GLU A  65
ALA A  16
SER A 196
 None
 0.69A 1errB-1yloA:
undetectable		 1errB-1yloA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		3 GLU A 117
ALA A 115
SER A  90
 None
 0.68A 1errB-2a6pA:
undetectable		 1errB-2a6pA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx6 XRP2 PROTEIN

(Homo sapiens) 		PF07986
(TBCC) 		3 GLU A 331
ALA A 333
SER A 327
 None
 0.59A 1errB-2bx6A:
undetectable		 1errB-2bx6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3

(Homo sapiens) 		PF01412
(ArfGap) 		3 GLU A 122
ALA A 117
SER A 114
 None
 0.53A 1errB-2crwA:
undetectable		 1errB-2crwA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8b TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		3 GLU A  38
ALA A  33
SER A  30
 None
 0.63A 1errB-2d8bA:
undetectable		 1errB-2d8bA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		3 GLU A 303
ALA A 301
SER A 297
 None
 0.68A 1errB-2gw1A:
undetectable		 1errB-2gw1A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6c CHLOROPHENOL
REDUCTION GENE K

(Desulfitobacterium
dehalogenans) 		PF13545
(HTH_Crp_2) 		3 GLU A 100
ALA A  38
SER A  41
 None
 0.70A 1errB-2h6cA:
undetectable		 1errB-2h6cA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jp7 MRNA EXPORT FACTOR
MEX67

(Saccharomyces
cerevisiae) 		PF03943
(TAP_C) 		3 GLU A 578
ALA A 580
SER A 573
 None
 0.66A 1errB-2jp7A:
undetectable		 1errB-2jp7A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o96 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 7

(Homo sapiens) 		PF01398
(JAB) 		3 GLU A 156
ALA A 137
SER A 160
 None
 0.57A 1errB-2o96A:
undetectable		 1errB-2o96A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p57 GTPASE-ACTIVATING
PROTEIN ZNF289

(Homo sapiens) 		PF01412
(ArfGap) 		3 GLU A 116
ALA A 111
SER A 108
 None
 0.67A 1errB-2p57A:
undetectable		 1errB-2p57A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx2 SEX PHEROMONE
STAPH-CAM373

(Staphylococcus
aureus) 		PF07537
(CamS) 		3 GLU A 297
ALA A 292
SER A 289
 None
 0.60A 1errB-2qx2A:
undetectable		 1errB-2qx2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcf UNIDENTIFIED
CARBOXYSOME
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF03319
(EutN_CcmL) 		3 GLU A  60
ALA A  62
SER A  69
 None
 0.67A 1errB-2rcfA:
undetectable		 1errB-2rcfA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x56 COAGULASE/FIBRINOLYS
IN

(Yersinia pestis) 		PF01278
(Omptin) 		3 GLU A 111
ALA A 109
SER A  74
 None
None
C8E  A1295 (-4.7A)
 0.38A 1errB-2x56A:
undetectable		 1errB-2x56A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 GLU A 602
ALA A 607
SER A 599
 None
 0.68A 1errB-2yl2A:
undetectable		 1errB-2yl2A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A 493
ALA A 495
SER A 318
 None
 0.69A 1errB-2z1qA:
1.1		 1errB-2z1qA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		3 GLU A 174
ALA A 172
SER A 168
 None
 0.67A 1errB-3ai2A:
undetectable		 1errB-3ai2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		3 GLU A 109
ALA A 104
SER A 101
 None
 0.64A 1errB-3b9yA:
1.4		 1errB-3b9yA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		3 GLU A 381
ALA A 372
SER A 385
 None
 0.67A 1errB-3bzmA:
undetectable		 1errB-3bzmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1

(Homo sapiens) 		PF00046
(Homeobox)
PF00157
(Pou) 		3 GLU I 189
ALA I 184
SER I 181
 None
 0.70A 1errB-3d1nI:
undetectable		 1errB-3d1nI:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		3 GLU A  83
ALA A  81
SER A  78
 None
 0.47A 1errB-3gfhA:
undetectable		 1errB-3gfhA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		3 GLU A  16
ALA A  11
SER A   8
 None
 0.58A 1errB-3gueA:
undetectable		 1errB-3gueA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		3 GLU A  30
ALA A  32
SER A  27
 None
 0.38A 1errB-3i0pA:
undetectable		 1errB-3i0pA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js9 NUCLEOSIDE
DIPHOSPHATE KINASE
FAMILY PROTEIN

(Babesia bovis) 		PF00334
(NDK) 		3 GLU A 121
ALA A 123
SER A 117
 None
 0.62A 1errB-3js9A:
undetectable		 1errB-3js9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxc REPRESSOR PROTEIN C2

(Salmonella
virus P22) 		PF01381
(HTH_3) 		3 GLU L  39
ALA L  34
SER L  31
 None
 0.60A 1errB-3jxcL:
undetectable		 1errB-3jxcL:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS

(Vibrio
parahaemolyticus) 		PF02661
(Fic) 		3 GLU A 139
ALA A 141
SER A  96
 None
 0.60A 1errB-3letA:
undetectable		 1errB-3letA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Streptococcus
agalactiae) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLU A  22
ALA A  24
SER A 152
 None
 0.69A 1errB-3lk7A:
undetectable		 1errB-3lk7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqh PUTATIVE
UNCHARACTERIZED
PROTEIN YVMC

(Bacillus
licheniformis) 		PF16715
(CDPS) 		3 GLU A  70
ALA A 177
SER A 151
 None
 0.63A 1errB-3oqhA:
undetectable		 1errB-3oqhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A 504
ALA A 502
SER A 498
 None
 0.71A 1errB-3owaA:
1.8		 1errB-3owaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A 504
ALA A 506
SER A 320
 None
 0.55A 1errB-3owaA:
1.8		 1errB-3owaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj9 NUCLEOSIDE
DIPHOSPHATE KINASE

(Campylobacter
jejuni) 		PF00334
(NDK) 		3 GLU A 121
ALA A 123
SER A 117
 None
 0.66A 1errB-3pj9A:
undetectable		 1errB-3pj9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjv PUTATIVE SEL1 REPEAT
PROTEIN

(Klebsiella
pneumoniae) 		PF08238
(Sel1) 		3 GLU A 213
ALA A 180
SER A 171
 None
 0.66A 1errB-3rjvA:
undetectable		 1errB-3rjvA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rvx PEPTIDASE 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		3 GLU A  44
ALA A  46
SER A 136
 CA  A 223 ( 4.9A)
None
None
 0.60A 1errB-3rvxA:
undetectable		 1errB-3rvxA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqw METHIONINE-BINDING
PROTEIN

(Coxiella
burnetii) 		PF03180
(Lipoprotein_9) 		3 GLU A  11
ALA A   8
SER A  36
 MET  A 238 (-3.2A)
None
None
 0.70A 1errB-3tqwA:
undetectable		 1errB-3tqwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 GLU A 217
ALA A 203
SER A 308
 None
 0.67A 1errB-3ue3A:
undetectable		 1errB-3ue3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 GLU B 831
ALA B 826
SER B 823
 None
 0.56A 1errB-3v0aB:
undetectable		 1errB-3v0aB:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		3 GLU A 377
ALA A  48
SER A  51
 None
 0.65A 1errB-3v39A:
undetectable		 1errB-3v39A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgs NUCLEOSIDE
DIPHOSPHATE KINASE

(Halomonas sp.
#593) 		PF00334
(NDK) 		3 GLU A 123
ALA A 125
SER A 119
 None
 0.62A 1errB-3vgsA:
undetectable		 1errB-3vgsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zd1 COMPLEMENT FACTOR
H-RELATED PROTEIN 2

(Homo sapiens) 		PF00084
(Sushi) 		3 GLU A 129
ALA A 151
SER A 154
 None
 0.56A 1errB-3zd1A:
undetectable		 1errB-3zd1A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		3 GLU A 249
ALA A 244
SER A 148
 None
 0.60A 1errB-3zpxA:
undetectable		 1errB-3zpxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acj WU:FB25H12 PROTEIN,

(Danio rerio) 		PF07534
(TLD) 		3 GLU A 796
ALA A 666
SER A 799
 None
 0.58A 1errB-4acjA:
undetectable		 1errB-4acjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak8 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER K

(Homo sapiens) 		PF00059
(Lectin_C) 		3 GLU A 261
ALA A 258
SER A 265
 None
 0.69A 1errB-4ak8A:
undetectable		 1errB-4ak8A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 GLU A 327
ALA A 329
SER A 358
 None
 0.66A 1errB-4aplA:
undetectable		 1errB-4aplA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 GLU B1687
ALA B1685
SER B1681
 None
 0.59A 1errB-4bedB:
undetectable		 1errB-4bedB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jig DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		3 GLU A  46
ALA A  44
SER A  16
 None
None
ACT  A 301 ( 3.8A)
 0.68A 1errB-4jigA:
undetectable		 1errB-4jigA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		3 GLU A  86
ALA A  81
SER A  78
 None
 0.65A 1errB-4kf6A:
undetectable		 1errB-4kf6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		3 GLU A 148
ALA A 143
SER A 140
 None
 0.55A 1errB-4m5pA:
undetectable		 1errB-4m5pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1r REPLICATIVE DNA
HELICASE

(Nostoc
punctiforme) 		PF14890
(Intein_splicing) 		3 GLU A 118
ALA A   3
SER A   6
 None
 0.70A 1errB-4o1rA:
undetectable		 1errB-4o1rA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ote LIPOPROTEIN

(Clostridioides
difficile) 		PF03180
(Lipoprotein_9) 		3 GLU A 254
ALA A 249
SER A 246
 None
 0.59A 1errB-4oteA:
undetectable		 1errB-4oteA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po2 HEAT SHOCK 70 KDA
PROTEIN 1A/1B

(Homo sapiens) 		PF00012
(HSP70) 		3 GLU A 543
ALA A 541
SER A 537
 None
None
PO4  A 702 (-2.7A)
 0.58A 1errB-4po2A:
undetectable		 1errB-4po2A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpb LYSOSTAPHIN

(Staphylococcus
simulans) 		PF01551
(Peptidase_M23) 		3 GLU A 318
ALA A 343
SER A 254
 None
 0.68A 1errB-4qpbA:
undetectable		 1errB-4qpbA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqv INTERLEUKIN-3
RECEPTOR CLASS 2
SUBUNIT BETA

(Mus musculus) 		PF09240
(IL6Ra-bind)
PF09294
(Interfer-bind) 		3 GLU A 268
ALA A 266
SER A 263
 None
 0.59A 1errB-4qqvA:
undetectable		 1errB-4qqvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		3 GLU A1947
ALA A1949
SER A1932
 None
 0.69A 1errB-4r7yA:
undetectable		 1errB-4r7yA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		3 GLU A 895
ALA A 890
SER A 887
 None
 0.55A 1errB-4r7zA:
undetectable		 1errB-4r7zA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9z UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		3 GLU A 202
ALA A 204
SER A 239
 None
 0.58A 1errB-4r9zA:
undetectable		 1errB-4r9zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		3 GLU A 173
ALA A 171
SER A 167
 None
 0.70A 1errB-4wnzA:
undetectable		 1errB-4wnzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLU A 188
ALA A 186
SER A 182
 None
 0.69A 1errB-4wyrA:
undetectable		 1errB-4wyrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A 303
ALA A 320
SER A 323
 None
 0.54A 1errB-5ahkA:
undetectable		 1errB-5ahkA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c22 CHROMOSOMAL
HEMOLYSIN D

(Escherichia
coli) 		PF13437
(HlyD_3) 		3 GLU A 263
ALA A 265
SER A 230
 None
 0.70A 1errB-5c22A:
undetectable		 1errB-5c22A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5caa NUCLEOSIDE
DIPHOSPHATE KINASE

(Leishmania
major) 		PF00334
(NDK) 		3 GLU A 123
ALA A 125
SER A 119
 None
 0.67A 1errB-5caaA:
undetectable		 1errB-5caaA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwk DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 3 GLU A 139
ALA A 134
SER A 131
 None
 0.63A 1errB-5cwkA:
undetectable		 1errB-5cwkA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwm DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 3 GLU A 208
ALA A 203
SER A 200
 None
 0.67A 1errB-5cwmA:
undetectable		 1errB-5cwmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 GLU A  32
ALA A  34
SER A  49
 None
 0.56A 1errB-5gjeA:
undetectable		 1errB-5gjeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 GLU A 620
ALA A 359
SER A 623
 None
 0.68A 1errB-5ipwA:
undetectable		 1errB-5ipwA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfy DEOXYCYTIDINE
DEAMINASE

(Brassica
oleracea) 		PF00383
(dCMP_cyt_deam_1) 		3 GLU A  39
ALA A  41
SER A 106
 None
 0.57A 1errB-5jfyA:
undetectable		 1errB-5jfyA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		3 GLU A 387
ALA A 385
SER A 383
 None
 0.71A 1errB-5jxmA:
undetectable		 1errB-5jxmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE

(Schistosoma
mansoni) 		PF00334
(NDK) 		3 GLU A 121
ALA A 123
SER A 117
 None
 0.68A 1errB-5kk8A:
undetectable		 1errB-5kk8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		3 GLU A  82
ALA A  80
SER A 109
 None
 0.52A 1errB-5lmcA:
undetectable		 1errB-5lmcA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		3 GLU A 390
ALA A 386
SER A 383
 None
 0.56A 1errB-5lqdA:
undetectable		 1errB-5lqdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		3 GLU D 391
ALA D 292
SER D 295
 None
 0.66A 1errB-5mg3D:
undetectable		 1errB-5mg3D:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		3 GLU A 541
ALA A 543
SER A 412
 None
 0.51A 1errB-5mswA:
undetectable		 1errB-5mswA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		3 GLU A  61
ALA A  66
SER A  47
 None
 0.57A 1errB-5nnpA:
undetectable		 1errB-5nnpA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 3 GLU A 629
ALA A 631
SER A 677
 None
 0.49A 1errB-5o7eA:
undetectable		 1errB-5o7eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 GLU A 520
ALA A 522
SER A  20
 None
 0.58A 1errB-5vniA:
undetectable		 1errB-5vniA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wda GENERAL SECRETION
PATHWAY PROTEIN G

(Klebsiella
oxytoca) 		no annotation 3 GLU A  44
ALA A  42
SER A  38
 None
 0.68A 1errB-5wdaA:
undetectable		 1errB-5wdaA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5l ADER

(Acinetobacter
baumannii) 		PF00486
(Trans_reg_C) 		3 GLU A 204
ALA A 202
SER A 200
 GLU  A 204 ( 0.6A)
ALA  A 202 ( 0.0A)
SER  A 200 ( 0.0A)
 0.68A 1errB-5x5lA:
undetectable		 1errB-5x5lA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		no annotation 3 GLU C 591
ALA C 593
SER C 549
 None
 0.69A 1errB-5yfpC:
undetectable		 1errB-5yfpC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yow GLYCOPROTEIN
POLYPROTEIN

(Heartland virus) 		no annotation 3 GLU A 217
ALA A 229
SER A 293
 None
 0.70A 1errB-5yowA:
undetectable		 1errB-5yowA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Homo sapiens) 		no annotation 3 GLU A 303
ALA A 305
SER A 322
 None
 0.67A 1errB-5yx9A:
undetectable		 1errB-5yx9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 3 GLU A  71
ALA A 128
SER A  31
 None
 0.70A 1errB-6a8mA:
undetectable		 1errB-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 3 GLU B 446
ALA B 441
SER B 438
 None
None
SO4  B 903 (-4.1A)
 0.64A 1errB-6bywB:
undetectable		 1errB-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj0 TREHALOSE
PHOSPHATASE

(Pseudomonas
aeruginosa) 		no annotation 3 GLU A 248
ALA A 243
SER A 240
 None
 0.70A 1errB-6cj0A:
undetectable		 1errB-6cj0A:
undetectable